Article (Scientific journals)
Cardiometabolic risk: leg fat is protective during childhood.
Samouda, Hanen; De Beaufort, Carine; Stranges, Saverio et al.
2015In Pediatric Diabetes
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Keywords :
DXA; cardiometabolic risk; fat mass; leg fat; visceral fat
Abstract :
[en] BACKGROUND: Childhood obesity is associated with early cardiometabolic risk (CMR), increased risk of adulthood obesity, and worse health outcomes. Leg fat mass (LFM) is protective beyond total fat mass (TFM) in adults. However, the limited evidence in children remains controversial. OBJECTIVE: We investigated the relationship between LFM and CMR factors in youth. SUBJECTS: A total of 203 overweight/obese children, 7-17-yr-old, followed in the Pediatric Clinic, Luxembourg. METHODS: TFM and LFM by dual energy x-ray absorptiometry and a detailed set of CMR markers were analyzed. RESULTS: After TFM, age, sex, body mass index (BMI) Z-score, sexual maturity status, and physical activity adjustments, negative significant partial correlations were shown between LFM and homeostasis model assessment of insulin resistance (HOMA) (variance explained: 6.05% by LFM*; 7.18% by TFM**), fasting insulin (variance explained: 5.71% by LFM*; 6.97% by TFM**), triglycerides (variance explained: 3.96% by LFM*; 2.76% by TFM*), systolic blood pressure (variance explained: 2.68% by LFM*; 4.33% by TFM*), C-reactive protein (variance explained: 2.31% by LFM*; 4.28% by TFM*), and resistin (variance explained: 2.16% by LFM*; 3.57% by TFM*). Significant positive partial correlations were observed between LFM and high-density lipoprotein (HDL) cholesterol (variance explained: 4.16% by LFM*) and adiponectin (variance explained: 3.09% by LFM*) (*p-value < 0.05 and **p-value < 0.001). In order to adjust for multiple testing, Benjamini-Hochberg method was applied and the adjusted significance level was determined for each analysis. LFM remained significant in the aforementioned models predicting HOMA, fasting insulin, triglycerides, and HDL cholesterol (Benjamini and Hochberg corrected p-value < 0.01). CONCLUSIONS: LFM is protective against CMR in children, at least in terms of insulin resistance and adverse blood lipid profiles.
Disciplines :
Life sciences: Multidisciplinary, general & others
Author, co-author :
Samouda, Hanen
De Beaufort, Carine ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Stranges, Saverio
Hirsch, Marco
Van Nieuwenhuyse, Jean-Paul
Dooms, Georges
Gilson, Georges
Keunen, Olivier
Leite, Sonia
Vaillant, Michel
Lair, Marie-Lise
Dadoun, Frederic
External co-authors :
Language :
Title :
Cardiometabolic risk: leg fat is protective during childhood.
Publication date :
17 June 2015
Journal title :
Pediatric Diabetes
Publisher :
Blackwell, Oxford, United Kingdom
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
(c) 2015 The Authors. Pediatric Diabetes published by John Wiley & Sons Ltd.
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