![]() ; ; et al E-print/Working paper (2021) Charcot-Marie-Tooth (CMT) disease 4A is an autosomal-recessive polyneuropathy caused by mutations of ganglioside-induced differentiation-associated protein 1 (GDAP1), a putative glutathione transferase ... [more ▼] Charcot-Marie-Tooth (CMT) disease 4A is an autosomal-recessive polyneuropathy caused by mutations of ganglioside-induced differentiation-associated protein 1 (GDAP1), a putative glutathione transferase, which affects mitochondrial shape and alters cellular Ca2+ homeostasis. Here, we identify the underlying mechanism. We found that patient-derived motoneurons and GDAP1 knockdown SH-SY5Y cells display two phenotypes: more tubular mitochondria and a metabolism characterized by glutamine dependence and fewer cytosolic lipid droplets. GDAP1 interacts with the actin-depolymerizing protein Cofilin-1 in a redoxdependent manner, suggesting a role for actin signaling. Consistently, GDAP1 loss causes less F-actin close to mitochondria, which restricts mitochondrial localization of the fission factor dynamin-related protein 1, instigating tubularity. Changes in the actin cytoskeleton also disrupt mitochondria-ER contact sites. This results in lower mitochondrial Ca2+ levels and inhibition of the pyruvate dehydrogenase complex, explaining the metabolic changes upon GDAP1 loss of function. Together, these findings reconcile GDAP1-associated phenotypes and implicate disrupted actin signaling in CMT4A pathophysiology. [less ▲] Detailed reference viewed: 42 (3 UL)![]() Nourdin, Ivan ![]() E-print/Working paper (2021) Detailed reference viewed: 93 (3 UL)![]() Zanaj, Skerdilajda ![]() E-print/Working paper (2021) Detailed reference viewed: 289 (41 UL)![]() Hussinger, Katrin ![]() E-print/Working paper (2021) Detailed reference viewed: 163 (9 UL)![]() Ojdanic, Milos ![]() ![]() ![]() E-print/Working paper (2021) Detailed reference viewed: 107 (19 UL)![]() ; ; et al E-print/Working paper (2021) In statistics, samples are drawn from a population in a data-generating process (DGP). Standard errors measure the uncertainty in estimates of population parameters. In science, evidence is generated to ... [more ▼] In statistics, samples are drawn from a population in a data-generating process (DGP). Standard errors measure the uncertainty in estimates of population parameters. In science, evidence is generated to test hypotheses in an evidence-generating process (EGP). We claim that EGP variation across researchers adds uncertainty: Non-standard errors (NSEs). We study NSEs by letting 164 teams test the same hypotheses on the same data. NSEs turn out to be sizable, but smaller for better reproducible or higher rated research. Adding peer-review stages reduces NSEs. We further find that this type of uncertainty is underestimated by participants. [less ▲] Detailed reference viewed: 27 (1 UL)![]() ; ; et al E-print/Working paper (2021) Detailed reference viewed: 47 (0 UL)![]() Biryukov, Alexei ![]() ![]() ![]() E-print/Working paper (2021) We propose a tool for automated truncation of differential trails in ciphers using modular addition, bitwise rotation, and XOR (ARX). The tool takes as input a differential trail and produces as output a ... [more ▼] We propose a tool for automated truncation of differential trails in ciphers using modular addition, bitwise rotation, and XOR (ARX). The tool takes as input a differential trail and produces as output a set of truncated differential trails. The set represents all possible truncations of the input trail according to certain predefined rules. A linear-time algorithm for the exact computation of the differential probability of a truncated trail that follows the truncation rules is proposed. We further describe a method to merge the set of truncated trails into a compact set of non-overlapping truncated trails with associated probability and we demonstrate the application of the tool on block cipher Speck64. We have also investigated the effect of clustering of differential trails around a fixed input trail. The best cluster that we have found for 15 rounds has probability 2^−55.03 (consisting of 389 unique output differences) which allows us to build a distinguisher using 128 times less data than the one based on just the single best trail, which has probability 2^−62. Moreover, we show examples for Speck64 where a cluster of trails around a suboptimal (in terms of probability) input trail results in higher overall probability compared to a cluster obtained around the best differential trail. [less ▲] Detailed reference viewed: 58 (7 UL)![]() Ebrahimi, Ehsan ![]() E-print/Working paper (2021) Detailed reference viewed: 44 (10 UL)![]() Notarnicola, Luca ![]() ![]() E-print/Working paper (2021) We consider the problem of revealing a small hidden lattice from the knowledge of a low-rank sublattice modulo a given sufficiently large integer -- the {\em Hidden Lattice Problem}. A central motivation ... [more ▼] We consider the problem of revealing a small hidden lattice from the knowledge of a low-rank sublattice modulo a given sufficiently large integer -- the {\em Hidden Lattice Problem}. A central motivation of study for this problem is the Hidden Subset Sum Problem, whose hardness is essentially determined by that of the hidden lattice problem. We describe and compare two algorithms for the hidden lattice problem: we first adapt the algorithm by Nguyen and Stern for the hidden subset sum problem, based on orthogonal lattices, and propose a new variant, which we explain to be related by duality in lattice theory. Following heuristic, rigorous and practical analyses, we find that our new algorithm brings some advantages as well as a competitive alternative for algorithms for problems with cryptographic interest, such as Approximate Common Divisor Problems, and the Hidden Subset Sum Problem. Finally, we study variations of the problem and highlight its relevance to cryptanalysis. [less ▲] Detailed reference viewed: 51 (0 UL)![]() Zetzsche, Dirk Andreas ![]() E-print/Working paper (2021) Detailed reference viewed: 80 (4 UL)![]() Sun, Zhe ![]() E-print/Working paper (2020) Detailed reference viewed: 53 (0 UL)![]() ![]() Owiso, Owiso ![]() E-print/Working paper (2020) Detailed reference viewed: 40 (0 UL)![]() ![]() Owiso, Owiso ![]() E-print/Working paper (2020) Detailed reference viewed: 44 (1 UL)![]() Alexandraki, Chrysa ![]() E-print/Working paper (2020) Detailed reference viewed: 85 (3 UL)![]() Lupinu, Pier Mario ![]() E-print/Working paper (2020) To date, the resolution of the Banco Popular Español, being the first and only resolution case in the euro area, has had the “benefit” of bringing to light several shortfalls of this crisis management ... [more ▼] To date, the resolution of the Banco Popular Español, being the first and only resolution case in the euro area, has had the “benefit” of bringing to light several shortfalls of this crisis management system. Back then, thanks to the sale of business, the need of the use of the Single Resolution Fund (SRF) has been avoided, prompting criticism on whether the fund had sufficient means to overcome a major widespread crisis. During the period elapsed from the last financial crisis, the euro area banking sector has built capital and liquidity buffers, which were aimed at protecting them for future shocks. Although it is now widely accepted that crises are of a cyclical nature, new risks and the high interconnectivity of today’s economic activities brought an unexpected crisis due to the current pandemic. The consequences of this unprecedented event in modern history had severe effects to the worldwide economy, mostly for the boundless block of labour activities, which caused severe losses for households, enterprises and governments that consequently affected the financial intermediation function of the banks. Concerning the European Stability Mechanism (ESM), the current pandemic has had the effect to put temporary on hold the discussion on the revision of the ESM Treaty, including its role as a Backstop to the SRF, so that the Mechanism could experience a new role through the ESM Pandemic Crisis Support. In such a framework, this paper aims to bring back the attention to the unfinished path in the establishment of the Common Backstop by addressing an important element of risk, namely its decision-making process. The main aim is to explore possible governance issues, which could hamper a timely and effective use of the Common Backstop, in the case that the SRF would be depleted and no alternative funding sources would be available. [less ▲] Detailed reference viewed: 52 (3 UL)![]() Margue, Michel ![]() E-print/Working paper (2020) Detailed reference viewed: 75 (5 UL)![]() ; ; Grotto, Francesco ![]() E-print/Working paper (2020) We introduce a new particle model, which we dub Active Bi-Directional Flow, conjugated to the Totally Asymmetric Exclusion Processin discrete time. We then associate to our model intrinsically stochastic ... [more ▼] We introduce a new particle model, which we dub Active Bi-Directional Flow, conjugated to the Totally Asymmetric Exclusion Processin discrete time. We then associate to our model intrinsically stochastic, non-entropic weak solutions of Burgers’ equation onR, thus linking the latter tothe KPZ universality class. [less ▲] Detailed reference viewed: 46 (2 UL)![]() Sischka, Philipp ![]() ![]() E-print/Working paper (2020) Im Rahmen dieser Newsletter wird analysiert, wie sich emotionale Anforderungen für Arbeitnehmer in Luxemburg über die letzten Jahre entwickelt haben. Emotionale Anforderungen sind mit reduziertem Well ... [more ▼] Im Rahmen dieser Newsletter wird analysiert, wie sich emotionale Anforderungen für Arbeitnehmer in Luxemburg über die letzten Jahre entwickelt haben. Emotionale Anforderungen sind mit reduziertem Well-Being assoziiert. Dabei weisen Arbeitnehmer mit ausgeprägten emotionalen Anforderungen insbesondere ein höheres Burnoutlevel auf. Zwischen 2016 und 2020 kam es zu einem deutlichen Anstieg der emotionalen Anforderungen. Arbeitnehmerinnen weisen über die Zeit konstant höhere emotionale Anforderungen auf im Vergleich zu Arbeitnehmern. Insbesondere Arbeitnehmer in akademischen Berufen, Manager und Arbeitnehmer in Dienstleistungsberufen weisen über die Zeit konstant hohe emotionale Anforderungen auf. Bediener von Anlagen und Hilfsarbeitskräfte weisen dagegen einen Anstieg zwischen 2016 und 2020 auf. [less ▲] Detailed reference viewed: 78 (1 UL)![]() Happold, Matthew ![]() E-print/Working paper (2020) This paper examines how arbitral proceedings and domestic criminal processes can interact; how parties to arbitrations have attempted to use domestic criminal proceedings to advance their interests; and ... [more ▼] This paper examines how arbitral proceedings and domestic criminal processes can interact; how parties to arbitrations have attempted to use domestic criminal proceedings to advance their interests; and how arbitral tribunals can and should respond to such attempts. It concludes that arbitral tribunals must take account of concurrent national criminal proceedings but cannot defer entirely to them. This is not only because they undertake a different role but also because national authorities cannot always entirely be trusted. In turn, this means that tribunals can find themselves between Scylla and Charybdis, so that arbitrators must be skillful navigators to get safely to their destination: an enforceable award. [less ▲] Detailed reference viewed: 16 (2 UL)![]() Mavi, Can Askan ![]() E-print/Working paper (2020) Motivated by recent discussions about the issue of risk perceptions for climate change related events, we introduce a non-cooperative game setting where agents manage a common pool resource under a ... [more ▼] Motivated by recent discussions about the issue of risk perceptions for climate change related events, we introduce a non-cooperative game setting where agents manage a common pool resource under a potential risk, and agents exhibit different risk perception biases. Focusing on the effect of the polarization level and other population features, we show that the type of bias (overestimation versus underestimation biases) and the resource quality level before and after the occurrence of the shift have first-order importance on the qualitative nature of behavioral adjustments and on the pattern of resource conservation. When there are non-uniform biases within the population, the intra-group structure of the population qualitatively affects the degree of resource conservation. Moreover, unbiased agents may react in nonmonotone ways to changes in the polarization level when faced with agents exhibiting different types of bias. The size of the unbiased agents’ sub-population does not qualitatively affect how an increase in the polarization level impacts individual behavioral adjustments, even though it affects the magnitude of this change. Finally, it is shown how perception biases affect the comparison between centralized and decentralized management. [less ▲] Detailed reference viewed: 70 (0 UL)![]() ; Kchouri, Bilal ![]() ![]() E-print/Working paper (2020) Detailed reference viewed: 130 (16 UL)![]() ; ; Schmidt, Thomas ![]() E-print/Working paper (2020) Detailed reference viewed: 38 (0 UL)![]() Montes Vinas, Ana Cecilia ![]() ![]() ![]() E-print/Working paper (2020) In this paper, we push forward the hypothesis that misalignment between expectations and aspirations crucially affects the educational outcomes of young adults. Using AddHealth, a dataset of 20,774 <br ... [more ▼] In this paper, we push forward the hypothesis that misalignment between expectations and aspirations crucially affects the educational outcomes of young adults. Using AddHealth, a dataset of 20,774 <br />adolescents between the grades 7-12, we show that the difference in school performance between migrant children and natives lies within the aspirations and expectations that migrant children form. More <br />specifically, we find that positive misalignment between aspirations and expectations is a driving force <br />for higher effort and better education outcomes of immigrant teenagers in the USA. This force resolves <br />the well-known immigrant paradox. Furthermore, this result is specific to migrant children and does not <br />hold for second-generation migrant pupils. [less ▲] Detailed reference viewed: 221 (29 UL)![]() Dehghani, Hamidreza ![]() ![]() E-print/Working paper (2020) We introduce a hybrid "Modified Genetic Algorithm-Multilevel Stochastic Gradient Descent" (MGA-MSGD) training algorithm that considerably improves accuracy and efficiency of solving 3D mechanical problems ... [more ▼] We introduce a hybrid "Modified Genetic Algorithm-Multilevel Stochastic Gradient Descent" (MGA-MSGD) training algorithm that considerably improves accuracy and efficiency of solving 3D mechanical problems described, in strong-form, by PDEs via ANNs (Artificial Neural Networks). This presented approach allows the selection of a number of locations of interest at which the state variables are expected to fulfil the governing equations associated with a physical problem. Unlike classical PDE approximation methods such as finite differences or the finite element method, there is no need to establish and reconstruct the physical field quantity throughout the computational domain in order to predict the mechanical response at specific locations of interest. The basic idea of MGA-MSGD is the manipulation of the learnable parameters’ components responsible for the error explosion so that we can train the network with relatively larger learning rates which avoids trapping in local minima. The proposed training approach is less sensitive to the learning rate value, training points density and distribution, and the random initial parameters. The distance function to minimise is where we introduce the PDEs including any physical laws and conditions (so-called, Physics Informed ANN). The Genetic algorithm is modified to be suitable for this type of ANN in which a Coarse-level Stochastic Gradient Descent (CSGD) is exploited to make the decision of the offspring qualification. Employing the presented approach, a considerable improvement in both accuracy and efficiency, compared with standard training algorithms such classical SGD and Adam optimiser, is observed. The local displacement accuracy is studied and ensured by introducing the results of Finite Element Method (FEM) at sufficiently fine mesh as the reference displacements. A slightly more complex problem is solved ensuring the feasibility of the methodology [less ▲] Detailed reference viewed: 85 (3 UL)![]() Beine, Michel ![]() E-print/Working paper (2020) In this paper, I propose to isolate the role of age as a self-selection factor of international migration. The role of age is estimated on intended emigration rather than on observed outcomes of migration ... [more ▼] In this paper, I propose to isolate the role of age as a self-selection factor of international migration. The role of age is estimated on intended emigration rather than on observed outcomes of migration, using individual measures of intended emigration drawn from a large-scale survey conducted by Gallup. I find evidence that age has a monotonic negative effect on desired emigration for the working-age population. The estimations point to a very robust effect, suggesting that an additional year of age decreases the probability of intended emigration by about 0.5%. This effect is steady over different periods of time and for most types of countries of origin. The results contrast with previous evidence obtained on observed outcomes of migration, suggesting that out-selection factors interact with age and shape the demographic profile of migrants. [less ▲] Detailed reference viewed: 58 (5 UL)![]() Mahe, Clotilde ![]() E-print/Working paper (2020) Identifying the impact of incapacitation measures on crime, such as imprisonment or curfews, is challenging since any such intervention simultaneously dissuades from engaging in illegal behaviour. We ... [more ▼] Identifying the impact of incapacitation measures on crime, such as imprisonment or curfews, is challenging since any such intervention simultaneously dissuades from engaging in illegal behaviour. We exploit Covid-19 confinement measures as a quasi-experiment to isolate incapacitative from deterrent effects of mobility restrictions in a developing country, Ecuador. Difference-in-differences and event-study estimates show a significant reduction in violent and property crime, relative to comparable months in pandemic-free years. While the fall in violent crime is driven by rape cases, we observe no cross-crime substitution for property crime. Heterogeneity effect analysis indicates that the composite decline in violent crime is entirely attributed to incapacitation. In contrast, the drop in property crime is attenuated in provinces where the economic activity mainly relies on essential sectors and blue-collar occupations, leaving incapacitation to explain 40 to 50% of the composite decrease. [less ▲] Detailed reference viewed: 74 (0 UL)![]() Schymanski, Emma ![]() ![]() E-print/Working paper (2020) Detailed reference viewed: 105 (0 UL)![]() Mellinger, Lukas ![]() E-print/Working paper (2020) In der Reaktion auf die Ausbreitung der Covid-19-Pandemie kam es weltweit für viele Menschen zum Bruch sozialer und räumlicher Routinen. In Deutschland haben die Landesregierungen die führende Rolle beim ... [more ▼] In der Reaktion auf die Ausbreitung der Covid-19-Pandemie kam es weltweit für viele Menschen zum Bruch sozialer und räumlicher Routinen. In Deutschland haben die Landesregierungen die führende Rolle beim Versuchübernommen, durch Verfügungen und Verordnungen die weitere Ausbreitung der Pandemie einzu-dämmen. In diesem Kontexthatdie Art und Weise wie Gesetze und Regeln Alltagsräume durchdringen für viele Menschen eine neue (unmittelbar erlebbare) Dimension angenommen. Ziel dieses Beitrags ist es,mit einem Fokus auf die getroffenenMaßnahmen der saarländischen Landesregierung diesbezüglich eine lo-kale Perspektive zu entwickeln. Durch die qualitative Methode der Autofotographie werden dabei individu-elle Sichtweisen auf das zugrundeliegendeWechselspiel von Recht, Raum und Gesellschaft in den Vorder-grund der Analyse gestellt.Durch den Blick auf sozialräumliche Zusammenhänge werden so die Auswirkun-gen der getroffenen Maßnahmen hinterfragt. [less ▲] Detailed reference viewed: 150 (18 UL)![]() Bruce, Andrew ![]() ![]() ![]() E-print/Working paper (2020) Detailed reference viewed: 105 (14 UL)![]() Baraud, Yannick ![]() ![]() E-print/Working paper (2020) Detailed reference viewed: 309 (73 UL)![]() ; Robert, Louis-Hadrien ![]() E-print/Working paper (2020) Detailed reference viewed: 43 (4 UL)![]() Amorino, Chiara ![]() E-print/Working paper (2020) In this paper, we consider a one-dimensional diffusion process with jumps driven by a Hawkes process. We are interested in the estimations of the volatility function and of the jump function from discrete ... [more ▼] In this paper, we consider a one-dimensional diffusion process with jumps driven by a Hawkes process. We are interested in the estimations of the volatility function and of the jump function from discrete high-frequency observations in long time horizon. We first propose to estimate the volatility coefficient. For that, we introduce in our estimation procedure a truncation function that allows to take into account the jumps of the process and we estimate the volatility function on a linear subspace of L 2 (A) where A is a compact interval of R. We obtain a bound for the empirical risk of the volatility estimator and establish an oracle inequality for the adaptive estimator to measure the performance of the procedure. Then, we propose an estimator of a sum between the volatility and the jump coefficient modified with the conditional expectation of the intensity of the jumps. The idea behind this is to recover the jump function. We also establish a bound for the empirical risk for the non-adaptive estimator of this sum and an oracle inequality for the final adaptive estimator. We conduct a simulation study to measure the accuracy of our estimators in practice and we discuss the possibility of recovering the jump function from our estimation procedure. [less ▲] Detailed reference viewed: 39 (2 UL)![]() Amorino, Chiara ![]() E-print/Working paper (2020) We study the problem of the non-parametric estimation for the density π of the stationary distribution of the multivariate stochastic differential equation with jumps (Xt)0≤t≤T , when the dimension d is ... [more ▼] We study the problem of the non-parametric estimation for the density π of the stationary distribution of the multivariate stochastic differential equation with jumps (Xt)0≤t≤T , when the dimension d is such that d ≥ 3. From the continuous observa- tion of the sampling path on [0, T ] we show that, under anisotropic H ̈older smoothness constraints, kernel based estimators can achieve fast convergence rates. In particu- lar, they are as fast as the ones found by Dalalyan and Reiss [9] for the estimation of the invariant density in the case without jumps under isotropic H ̈older smooth- ness constraints. Moreover, they are faster than the ones found by Strauch [29] for the invariant density estimation of continuous stochastic differential equations, under anisotropic H ̈older smoothness constraints. Furthermore, we obtain a minimax lower bound on the L2-risk for pointwise estimation, with the same rate up to a log(T) term. It implies that, on a class of diffusions whose invariant density belongs to the anisotropic Holder class we are considering, it is impossible to find an estimator with a rate of estimation faster than the one we propose. [less ▲] Detailed reference viewed: 58 (9 UL)![]() Kalugin, Alexey ![]() E-print/Working paper (2020) Detailed reference viewed: 158 (17 UL)![]() ; Sahu, Rajeev Anand ![]() E-print/Working paper (2020) Detailed reference viewed: 42 (3 UL)![]() ; Mombaerts, Laurent ![]() ![]() E-print/Working paper (2020) Background: The role of schools and children in the transmission of SARS-CoV-2 remains to be determined. Following a first wave in spring and gradual easing of lockdown, Luxembourg experienced an early ... [more ▼] Background: The role of schools and children in the transmission of SARS-CoV-2 remains to be determined. Following a first wave in spring and gradual easing of lockdown, Luxembourg experienced an early second epidemic wave before the start of summer school holidays on 15th July. This provided the opportunity to study the role of school-age children and school settings in SARS-CoV-2 transmission. More specifically, we compared the incidence in school-age children, teachers and the general working population, and estimated the number of secondary transmissions occurring at schools using contact tracing data. Findings: While SARS-CoV-2 incidence was much higher in adults aged 20 and above than in children aged 0 to 19 during the first wave in spring, no significant difference was found during the second wave in early summer. The incidence during the second wave was similar for pupils, teachers and the general working population. Based on a total of 424 reported confirmed COVID-19 cases in school-age children and teachers, we estimate that 179 index cases caused 49 secondary transmissions in schools. While some small clusters of mainly student-to-student transmission within the same class were identified, we did not observe any large outbreaks with multiple generations of infection. Interpretation: Transmission of SARS-CoV-2 within Luxembourg schools was limited during the early summer epidemic wave in 2020. Precautionary measures including physical distancing as well as easy access to testing, systematic contact tracing appears to have been successful in mitigating transmission within educational settings. Funding Statement: LV is supported by the Luxembourg National Research Fund grant COVID-19/2020- 1/14701707/REBORN, LM is supported by Luxembourg National Research Fund grant COVID19/14863306/PREVID, PW is supported by the European Research Council (ERC-CoG 863664). Declaration of Interests: No competing interests. Ethics Approval Statement: The Health Directorate has the legal permission to process patient confidential information for national surveillance of communicable diseases in general and contact tracing for the COVID-19 pandemic and individual patient consent is not required. [less ▲] Detailed reference viewed: 231 (10 UL)![]() ![]() Owiso, Owiso ![]() E-print/Working paper (2020) Detailed reference viewed: 103 (4 UL)![]() ![]() Owiso, Owiso ![]() E-print/Working paper (2020) Detailed reference viewed: 156 (8 UL)![]() Hofmann, Herwig ![]() E-print/Working paper (2020) Detailed reference viewed: 128 (6 UL)![]() Kafteranis, Dimitrios ![]() E-print/Working paper (2020) Detailed reference viewed: 42 (1 UL)![]() Kafteranis, Dimitrios ![]() E-print/Working paper (2020) Detailed reference viewed: 63 (0 UL)![]() Kirsch, Claudine ![]() ![]() ![]() E-print/Working paper (2020) Detailed reference viewed: 165 (21 UL)![]() ![]() Hiry, Jasmin ![]() E-print/Working paper (2020) Detailed reference viewed: 53 (2 UL)![]() Böwen, Petra ![]() ![]() E-print/Working paper (2020) This newsletter describes the job market in the social work sector in Luxembourg in 2019. The data are derived from an ongoing research project by the PraxisBüro of the University of Luxembourg. The ... [more ▼] This newsletter describes the job market in the social work sector in Luxembourg in 2019. The data are derived from an ongoing research project by the PraxisBüro of the University of Luxembourg. The newsletter presents a selection of statistics concerning for example the most sought after qualification levels, the distribution of practice fields, the distribution of job offers on public, municipal, privat an non-governmental organisations an the documented gab between the demand of social workers with a Bachelor diploma and the number of Bachelor diplomas issued in Luxembourg [less ▲] Detailed reference viewed: 822 (59 UL)![]() Garcia Santa Cruz, Beatriz ![]() ![]() ![]() E-print/Working paper (2020) Machine learning based methods for diagnosis and progression prediction of COVID-19 from imaging data have gained significant attention in the last months, in particular by the use of deep learning ... [more ▼] Machine learning based methods for diagnosis and progression prediction of COVID-19 from imaging data have gained significant attention in the last months, in particular by the use of deep learning models. In this context hundreds of models where proposed with the majority of them trained on public datasets. Data scarcity, mismatch between training and target population, group imbalance, and lack of documentation are important sources of bias, hindering the applicability of these models to real-world clinical practice. Considering that datasets are an essential part of model building and evaluation, a deeper understanding of the current landscape is needed. This paper presents an overview of the currently public available COVID-19 chest X-ray datasets. Each dataset is briefly described and potential strength, limitations and interactions between datasets are identified. In particular, some key properties of current datasets that could be potential sources of bias, impairing models trained on them are pointed out. These descriptions are useful for model building on those datasets, to choose the best dataset according the model goal, to take into account the specific limitations to avoid reporting overconfident benchmark results, and to discuss their impact on the generalisation capabilities in a specific clinical setting. [less ▲] Detailed reference viewed: 355 (10 UL)![]() ![]() Szendrei, Greta ![]() ![]() ![]() E-print/Working paper (2020) Detailed reference viewed: 64 (6 UL)![]() El Emam, Christian ![]() E-print/Working paper (2020) Given an oriented immersed hypersurface in hyperbolic space H^{n+1}, its Gauss map is defined with values in the space of oriented geodesics of H^{n+1}, which is endowed with a natural para-Kähler ... [more ▼] Given an oriented immersed hypersurface in hyperbolic space H^{n+1}, its Gauss map is defined with values in the space of oriented geodesics of H^{n+1}, which is endowed with a natural para-Kähler structure. In this paper we address the question of whether an immersion G of the universal cover of an n-manifold M, equivariant for some group representation of π1(M) in Isom(H^{n+1}), is the Gauss map of an equivariant immersion in H^{n+1}. We fully answer this question for immersions with principal curvatures in (−1,1): while the only local obstructions are the conditions that G is Lagrangian and Riemannian, the global obstruction is more subtle, and we provide two characterizations, the first in terms of the Maslov class, and the second (for M compact) in terms of the action of the group of compactly supported Hamiltonian symplectomorphisms [less ▲] Detailed reference viewed: 35 (3 UL)![]() Owiso, Owiso ![]() E-print/Working paper (2020) Detailed reference viewed: 118 (3 UL)![]() Lupinu, Pier Mario ![]() E-print/Working paper (2020) The flow of information is vital for the smooth functioning and certainty of the successful outcome of a resolution procedure during resolution planning and execution. As a result, the exchange of ... [more ▼] The flow of information is vital for the smooth functioning and certainty of the successful outcome of a resolution procedure during resolution planning and execution. As a result, the exchange of relevant information has become highly influential in current debates. This article will focus on the exchange of information between the Single Resolution Board (SRB) and the European Central Bank (ECB). Firstly, the Authorities decided to arrange the rules for sharing information bilaterally in the form of a Memorandum of Understanding (MoU). While this framework of cooperation and exchange of information between the SRB and the ECB constitutes an obligation under Article 30(7) of the Single Resolution Mechanism Regulation (SRMR), it was drafted in the non-binding form of an MoU. The general purpose of an MoU is to establish the basis for cooperation and convergence of intentions. Such foundations aim to strengthen the resolution procedure by joining forces to obtain more accurate and complete data with better coordination of tasks and resources in order to achieve the most solid result possible within a tighter timeframe. [less ▲] Detailed reference viewed: 180 (5 UL)![]() Tran Dinh, Hieu ![]() ![]() ![]() E-print/Working paper (2020) Unmanned aerial vehicle (UAV) communication has emerged as a prominent technology for emergency communications (e.g., natural disaster) in Internet of Things (IoT) networks to enhance the ability of ... [more ▼] Unmanned aerial vehicle (UAV) communication has emerged as a prominent technology for emergency communications (e.g., natural disaster) in Internet of Things (IoT) networks to enhance the ability of disaster prediction, damage assessment, and rescue operations promptly. In this paper, a UAV is deployed as a flying base station (BS) to collect data from time-constrained IoT devices and then transfer the data to a ground gateway (GW). In general, the latency constraint at IoT users and the limited storage capacity of UAV highly hinder practical applications of UAV-assisted IoT networks. In this paper, full-duplex (FD) technique is adopted at the UAV to overcome these challenges. In addition, half-duplex (HD) scheme for UAV-based relaying is also considered to provide a comparative study between two modes (viz., FD and HD). Herein, a device is successfully served iff its data is collected by UAV and conveyed to GW within the flight time. In this context, we aim at maximizing the number of served IoT devices by jointly optimizing bandwidth and power allocation, as well as the UAV trajectory, while satisfying the requested timeout (RT) requirement of each device and the UAV’s limited storage capacity. The formulated optimization problem is troublesome to solve due to its non-convexity and combinatorial nature. Toward appealing applications, we first relax binary variables into continuous values and transform the original problem into a more computationally tractable form. By leveraging inner approximation framework, we derive newly approximated functions for non-convex parts and then develop a simple yet efficient iterative algorithm for its solutions. Next, we attempt to maximize the total throughput subject to the number of served IoT devices. Finally, numerical results show that the proposed algorithms significantly outperform benchmark approaches in terms of the number of served IoT devices and the amount of collected data. [less ▲] Detailed reference viewed: 84 (7 UL)![]() Schlenker, Jean-Marc ![]() E-print/Working paper (2020) While the ``hierarchy of science'' has been widely analysed, there is no corresponding study of the status of subfields within a given scientific field. We use bibliometric data to show that subfields of ... [more ▼] While the ``hierarchy of science'' has been widely analysed, there is no corresponding study of the status of subfields within a given scientific field. We use bibliometric data to show that subfields of mathematics have a different ``standing'' within the mathematics community. Highly ranked departments tend to specialize in some subfields more than in others, and the same subfields are also over-represented in the most selective mathematics journals or among recipients of top prizes. Moreover this status of subfields evolves markedly over the period of observation (1984--2016), with some subfields gaining and others losing in standing. The status of subfields is related to different publishing habits, but some of those differences are opposite to those observed when considering the hierarchy of scientific fields. We examine possible explanations for the ``status'' of different subfields. Some natural explanations -- availability of funding, importance of applications -- do not appear to function, suggesting that factors internal to the discipline are at work. We propose a different type of explanation, based on a notion of ``focus'' of a subfield, that might or might not be specific to mathematics. [less ▲] Detailed reference viewed: 63 (1 UL)![]() Sommarribas, Adolfo ![]() E-print/Working paper (2020) The COVID-19 took by surprise most Member States of the European Union, as they underestimated the rapid spread of the contagion in the continent. The response of the Member States was asymmetrical ... [more ▼] The COVID-19 took by surprise most Member States of the European Union, as they underestimated the rapid spread of the contagion in the continent. The response of the Member States was asymmetrical, individualistic and significantly slow. The first measures taken were to close down the internal borders. The response of the European Union was even slower to the point that and it was not until March 17th 2020 that the external borders were closed. These actions affected legal migration into the European Union from four perspectives: 1) it affected the mobility of those third country nationals who were on temporary stay in the Member States; 2) the entry of third country nationals to do seasonal work; 3) the entry and stay of legal migrants; and 4) the status quo of the third country nationals already residing in the Member States, especially those who have a loss of income. This article will deal with the measures taken by Member States on who to manage the immigration services during the crisis as well as the measures taken in order to deal with overstayers, seasonal workers and other legal migrants. Finally, we will focus in the vulnerable situation that third-country national salaried workers are exposed due to the loss of income or loss of employment in the Member States and the risk of being returned to their country of origin. [less ▲] Detailed reference viewed: 104 (5 UL)![]() Ganschow, Inna ![]() E-print/Working paper (2020) The article provides an overview of different types of schools, teachers and their methods of teaching Russian in Luxembourg over the past 100 years. A distinction is made between the affiliation of ... [more ▼] The article provides an overview of different types of schools, teachers and their methods of teaching Russian in Luxembourg over the past 100 years. A distinction is made between the affiliation of schools and the values that they try to convey along with the Russian language. The article analyzes the motivation of parents and teachers in the transfer of oral or written knowledge of the native language. [less ▲] Detailed reference viewed: 81 (3 UL)![]() Sauter, Thomas ![]() ![]() E-print/Working paper (2020) The interpretation of the number of COVID-19 cases and deaths in a country or region is strongly dependent on the number of performed tests. We developed a novel SIR based epidemiological model (SIVRT ... [more ▼] The interpretation of the number of COVID-19 cases and deaths in a country or region is strongly dependent on the number of performed tests. We developed a novel SIR based epidemiological model (SIVRT) which allows the country-specific integration of testing information and other available data. The model thereby enables a dynamic inspection of the pandemic and allows estimating key figures, like the number of overall detected and undetected COVID-19 cases and the infection fatality rate. As proof of concept, the novel SIVRT model was used to simulate the first phase of the pandemic in Luxembourg. An overall number of infections of 13.000 and an infection fatality rate of 1,3 was estimated, which is in concordance with data from population-wide testing. Furthermore based on the data as of end of May 2020 and assuming a partial deconfinement, an increase of cases is predicted from mid of July 2020 on. This is consistent with the current observed rise and shows the predictive potential of the novel SIVRT model. [less ▲] Detailed reference viewed: 135 (11 UL)![]() ; Decouchant, Jérémie ![]() E-print/Working paper (2020) The accelerated digitalisation of society along with technological evolution have extended the geographical span of cyber-physical systems. Two main threats have made the reliable and real-time control of ... [more ▼] The accelerated digitalisation of society along with technological evolution have extended the geographical span of cyber-physical systems. Two main threats have made the reliable and real-time control of these systems challenging: (i) uncertainty in the communication infrastructure induced by scale, openness and heterogeneity of the environment and devices; and (ii) targeted attacks maliciously worsening the impact of the above-mentioned communication uncertainties, disrupting the correctness of real-time applications. This paper addresses those challenges by showing how to build distributed protocols that provide both real-time with practical performance, and scalability in the presence of network faults and attacks. We provide a suite of real-time Byzantine protocols, which we prove correct, starting from a reliable broadcast protocol, called PISTIS, up to atomic broadcast and consensus. This suite simplifies the construction of powerful distributed and decentralized monitoring and control applications, including state-machine replication. Extensive empirical evaluations show- case PISTIS’s robustness, latency, and scalability. For example, PISTIS can withstand message loss (and delay) rates up to 40% in systems with 49 nodes and provides bounded delivery latencies in the order of a few milliseconds. [less ▲] Detailed reference viewed: 168 (6 UL)![]() Zinonos, Panagiotis ![]() E-print/Working paper (2020) Detailed reference viewed: 64 (9 UL)![]() Ceron, Francisco ![]() E-print/Working paper (2020) Research on education inequalities has long-established the relationship between the social composition of of schools and achievement levels. However, the empirical study of the social processes in ... [more ▼] Research on education inequalities has long-established the relationship between the social composition of of schools and achievement levels. However, the empirical study of the social processes in choosing schools and their potential effects on achievement inequalities has often been neglected. This article investigates the extent to which such social processes, related to parents’ educational preferences and expectations, influence the development of students’ achievement inequalities throughout their schooling career, through shaping school communities, as a channel of transmission of socioeconomic inequality. Using longitudinal census data from Chile, which allows us to observe students’ achievements between the 4th and 10th grades, we find support for the claim that the development of achievement inequalities operate partly through well-off parents’ educational preferences and expectations. Moreover, these preferences and beliefs explain most of the social composition effect of schools on achievement inequalities. We conclude that choice processes should be considered as an integral part of theories aimed to explain achievement inequalities as a dynamic process. [less ▲] Detailed reference viewed: 39 (10 UL)![]() Sischka, Philipp ![]() ![]() E-print/Working paper (2020) Im Rahmen dieser Newsletter wird analysiert, in welchem Umfang Arbeitnehmer in Luxemburg an ihrem Arbeitsplatz von der Frustration dreier psychologischer Grundbedürfnisse – der Autonomie, der Kompetenz ... [more ▼] Im Rahmen dieser Newsletter wird analysiert, in welchem Umfang Arbeitnehmer in Luxemburg an ihrem Arbeitsplatz von der Frustration dreier psychologischer Grundbedürfnisse – der Autonomie, der Kompetenz, und der Verbundenheit – betroffen sind. Hierbei zeigt sich durchgängig bei den Arbeitnehmern, dass die Frustration über fehlende Autonomie am Stärksten ausgeprägt ist. Spezifische Arbeitsbedingungen, wie z.B. fehlende Partizipation sowie geringes Well-Being sindzudem besonders hoch mit Frustration korreliert. Vergleiche zwischen unterschiedlichen Arbeitnehmergruppen zeigen auf, dass Frauen gegenüber Männern ein etwas höheres Ausmaß der Frustration von Verbundenheit und von Kompetenz erleben. Manager zeigen hingegen ein geringeres Ausmaß der Frustration von Verbundenheit im Vergleich zu Arbeitnehmern in anderen Berufen. Arbeitnehmer, die in NGOs arbeiten, weisen wiederum das geringste Ausmaß an Frustration über fehlende Autonomie auf. [less ▲] Detailed reference viewed: 74 (3 UL)![]() ; ; et al E-print/Working paper (2020) The genetic basis of Lewy body dementia (LBD) is not well understood. Here, we performed whole-genome sequencing in large cohorts of LBD cases and neurologically healthy controls to study the genetic ... [more ▼] The genetic basis of Lewy body dementia (LBD) is not well understood. Here, we performed whole-genome sequencing in large cohorts of LBD cases and neurologically healthy controls to study the genetic architecture of this understudied form of dementia and to generate a resource for the scientific community. Genome-wide association analysis identified five independent risk loci, whereas genome-wide gene-aggregation tests implicated mutations in the gene GBA. Genetic risk scores demonstrate that LBD shares risk profiles and pathways with Alzheimer’s and Parkinson’s disease, providing a deeper molecular understanding of the complex genetic architecture of this age-related neurodegenerative condition.Competing Interest StatementThomas G. Beach is a consultant for Prothena, Vivid Genomics and Avid Radiopharmaceuticals. He is a scientific advisory board member for Vivid Genomics. John A. Hardy, Huw R. Morris, Stuart Pickering-Brown, Andrew B. Singleton, and Bryan J. Traynor hold US, EU and Canadian patents on the clinical testing and therapeutic intervention for the hexanucleotide repeat expansion of C9orf72. Michael A. Nalls is supported by a consulting contract between Data Tecnica International and the National Institute on Aging, NIH, Bethesda, MD, USA; as a possible conflict of interest Dr. Nalls also consults for Neuron23 Inc., Lysosomal Therapeutics Inc., Illumina Inc., the Michael J. Fox Foundation and Vivid Genomics among others. Jose A. Palma is an editorial board member of Movement Disorders, Parkinsonism & Related Disorders, BMC Neurology, and Clinical Autonomic Research. Bradley F. Boeve, James Leverenz, and Sonja W. Scholz serve on the Scientific Advisory Council of the Lewy Body Dementia Association. Sonja W. Scholz is an editorial board member for the Journal of Parkinson's Disease. Bryan J. Traynor is an editorial board member for JAMA Neurology; Journal of Neurology, Neurosurgery, and Psychiatry; Brain; and Neurobiology of Aging. Zbigniew K. Wszolek serves as a principal investigator or co-principal investigator on Abbvie, Inc. (M15-562 and M15-563), Biogen, Inc. (228PD201) grant, and Biohaven Pharmaceuticals, Inc. (BHV4157-206 and BHV3241-301). Zbigniew K. Wszolek serves as the principal investigator of the Mayo Clinic American Parkinson Disease Association (APDA) Information and Referral Center, and as co-principal investigator of the Mayo Clinic APDA Center for Advanced Research. All other authors report no competing interests. [less ▲] Detailed reference viewed: 211 (3 UL)![]() Baumgarth, Robert ![]() E-print/Working paper (2020) We prove using an integral criterion the existence and completeness of the wave operators corresponding to the Hodge-Laplacians acting on differential p-forms, induced by two quasi-isometric Riemannian ... [more ▼] We prove using an integral criterion the existence and completeness of the wave operators corresponding to the Hodge-Laplacians acting on differential p-forms, induced by two quasi-isometric Riemannian metrics g and h on a complete open smooth manifold M. In particular, this result provides a criterion for the absolutely continuous spectra to coincide. The proof is based on gradient estimates obtained by probabilistic Bismut-type formulae for the heat semigroup defined by spectral calculus. By these localised formulae, the integral criterion only requires local curvature bounds and some upper local control on the heat kernel acting on functions, but no control on the injectivity radii. A consequence is a stability result of the absolutely continuous spectrum under a Ricci flow. As an application we concentrate on the important case of conformal perturbations. [less ▲] Detailed reference viewed: 158 (6 UL)![]() Kocyigit, Cagil ![]() E-print/Working paper (2020) Detailed reference viewed: 15 (0 UL)![]() Epping, Elisabeth ![]() E-print/Working paper (2020) "Everything was booked and ready to go for a two-day scientific workshop on education policies in Europe, scheduled for April 23-24, 2020 at the Hertie School in Berlin. The workshop intended to take ... [more ▼] "Everything was booked and ready to go for a two-day scientific workshop on education policies in Europe, scheduled for April 23-24, 2020 at the Hertie School in Berlin. The workshop intended to take stock of developments at the European, national and sub-national levels given the European Union’s wrap up of its decade-long Education & Training 2020 strategy (ET 2020), a framework for cooperation in education and training. However, on March 12, we had to cancel the physical meeting on short notice due to the coronavirus crisis. In the following, we share our experiences with the subsequent transition to an alternative online workshop format that took place on April 23, involving 25 participants from 10 countries, and 16 paper presentations. After sketching the workshop’s virtual setup, we discuss strengths, weaknesses, and challenges related to this digital transition. Furthermore, we explore the prospects of such online formats for future academic conferences and networking." [less ▲] Detailed reference viewed: 1199 (7 UL)![]() Brüll, Christoph ![]() ![]() E-print/Working paper (2020) Detailed reference viewed: 106 (1 UL)![]() Pigeron-Piroth, Isabelle ![]() ![]() E-print/Working paper (2020) La crise sanitaire provoquée par la pandémie de COVID-19 a imposé d’importantes adaptations au marché du travail transfrontalier dans la Grande Région SaarLorLux. Les mesures prises pour éviter la ... [more ▼] La crise sanitaire provoquée par la pandémie de COVID-19 a imposé d’importantes adaptations au marché du travail transfrontalier dans la Grande Région SaarLorLux. Les mesures prises pour éviter la propagation de la maladie imposent de limiter les déplacements au strict minimum tandis que l’efficience des services de santé publics impose la proximité. Ces mesures, qui se sont rapidement imposées aux acteurs publics, aux entreprises et aux individus, questionnent directement le fonctionnement d’un marché du travail transfrontalier structuré par la mobilité transfrontalière. Afin de maintenir tant que possible les activités économiques et de pourvoir aux besoins sanitaires, les exécutifs nationaux ont adapté les fonctions de la frontière. [less ▲] Detailed reference viewed: 114 (18 UL)![]() ![]() Owiso, Owiso ![]() E-print/Working paper (2020) Detailed reference viewed: 66 (3 UL)![]() ; ; et al E-print/Working paper (2020) Coding and non-coding RNAs have diagnostic and prognostic importance in Parkinson’s diseases (PD). We studied circulating small non-coding RNAs (sncRNAs) in 7, 003 samples from two longitudinal PD cohorts ... [more ▼] Coding and non-coding RNAs have diagnostic and prognostic importance in Parkinson’s diseases (PD). We studied circulating small non-coding RNAs (sncRNAs) in 7, 003 samples from two longitudinal PD cohorts (Parkinson’s Progression Marker Initiative (PPMI) and Luxembourg Parkinson’s Study (NCER-PD)) and modelled their influence on the transcriptome. First, we sequenced sncRNAs in 5, 450 blood samples of 1, 614 individuals in PPMI. The majority of 323 billion reads (59 million reads per sample) mapped to miRNAs. Other covered RNA classes include piRNAs, rRNAs, snoRNAs, tRNAs, scaRNAs, and snRNAs. De-regulated miRNAs were associated with the disease and disease progression and occur in two distinct waves in the third and seventh decade of live. Originating mostly from a characteristic set of immune cells they resemble a systemic inflammation response and mitochondrial dysfunction, two hallmarks of PD. By profiling 1, 553 samples from 1, 024 individuals in the NCER-PD cohort using an independent technology, we validate relevant findings from the sequencing study. Finally, network analysis of sncRNAs and transcriptome sequencing of the original cohort identified regulatory modules emerging in progressing PD patients.Competing Interest StatementThe authors have declared no competing interest. [less ▲] Detailed reference viewed: 225 (11 UL)![]() ![]() Zanaj, Skerdilajda ![]() E-print/Working paper (2020) We define a model of international trade with two countries, two vertically differentiated goods, and heterogenous consumers concerning their willingness to pay for quality. Trade generates two sources of ... [more ▼] We define a model of international trade with two countries, two vertically differentiated goods, and heterogenous consumers concerning their willingness to pay for quality. Trade generates two sources of pollution: the production of domestic and traded goods, and their transportation between countries. Consumers in both countries manifest home bias which translates into ethnocentric preferences: (i) consumer perceive the quality of the domestic good amplified; and (ii) consumers thrive additional satisfaction when consuming a domestic good rather than a foreign one since only the former can satisfy their sense of place. By contrast, they suffer a psychological penalty when consuming a foreign product. We investigate the role of trade costs and ethnocentric attitude in shaping the equilibrium configuration of the international duopoly. Finally, we uncover the environmental damage from production and from transport in presence of ethnocentrism. [less ▲] Detailed reference viewed: 87 (12 UL)![]() Dusdal, Jennifer ![]() E-print/Working paper (2020) Detailed reference viewed: 87 (7 UL)![]() ; ; et al E-print/Working paper (2020) BACKGROUND: After the World Health Organization declared the outbreak of coronavirus disease to be a public health emergency of international concern on January 30, 2020, the first SARS-CoV-2 infection ... [more ▼] BACKGROUND: After the World Health Organization declared the outbreak of coronavirus disease to be a public health emergency of international concern on January 30, 2020, the first SARS-CoV-2 infection was detected in Luxembourg on February 29, 2020. Representative population-based data, including asymptomatic individuals for assessing the viral spread and immune response were, however, lacking worldwide. METHODS: Using a panel-based method, we implemented a representative sample of the Luxembourgish population based on age, gender and residency for testing for SARS-CoV-2 infection and antibody status in order to define prevalence irrespective of clinical symptoms. Participants were contacted via email to fill an online questionnaire before biosampling at local laboratories. All participants provided information related to clinical symptoms, epidemiology, socioeconomic and psychological assessments and underwent biosampling, rRT-PCR testing and serology for SARS-CoV-2. RESULTS: We included a total of 1862 individuals in our representative sample of the general Luxembourgish population. Of these, 5 individuals had a current positive result for infection with SARS-CoV-2 based on rRT-PCR. Four of these individuals were oligosymptomatic and one was asymptomatic. Overall we found a positive IgG antibody status in 35 individuals (1.97%), of which 11 reported to be tested positive by rRT-PCR for SARS-CoV-2 previously and showed in addition their IgG positive status also a positive status for IgA. Our data indicate a prevalence of 0.3% for active SARS-CoV-2 infection and an infection rate of 2.15% in the Luxembourgish population between 18 and 79 years of age. CONCLUSIONS: Luxembourgish residents show a low rate of acute infections after 7 weeks of confinement and present with an antibody profile indicative of a more recent immune response to SARS-CoV-2. All infected individuals were oligo- or asymptomatic. Bi-weekly follow-up visits over the next 2 months will inform about the viral spread by a- and oligosymptomatic carriers and the individual changes in the immune profile.Competing Interest StatementThe authors have declared no competing interest.Clinical TrialNCT04379297Funding StatementThe CON-VINCE Study is funded by the Research Fund Luxembourg (FNR; CON-VINCE) and the André Losch Foundation (Luxembourg).Author DeclarationsAll relevant ethical guidelines have been followed; any necessary IRB and/or ethics committee approvals have been obtained and details of the IRB/oversight body are included in the manuscript.YesAll necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesDue to ethical concerns, supporting data cannot be made openly available. [less ▲] Detailed reference viewed: 535 (35 UL)![]() Esteves-Verissimo, Paulo ![]() ![]() ![]() E-print/Working paper (2020) Contact tracing is an important instrument for national health services to fight epidemics. As part of the COVID-19 situation, many proposals have been made for scaling up contract tracing capacities with ... [more ▼] Contact tracing is an important instrument for national health services to fight epidemics. As part of the COVID-19 situation, many proposals have been made for scaling up contract tracing capacities with the help of smartphone applications, an important but highly critical endeavor due to the privacy risks involved in such solutions. Extending our previously expressed concern, we clearly articulate in this article, the functional and non-functional requirements that any solution has to meet, when striving to serve, not mere collections of individuals, but the whole of a nation, as required in face of such potentially dangerous epidemics. We present a critical information infrastructure, PriLock, a fully-open preliminary architecture proposal and design draft for privacy preserving contact tracing, which we believe can be constructed in a way to fulfill the former requirements. Our architecture leverages the existing regulated mobile communication infrastructure and builds upon the concept of "checks and balances", requiring a majority of independent players to agree to effect any operation on it, thus preventing abuse of the highly sensitive information that must be collected and processed for efficient contact tracing. This is enforced with a largely decentralised layout and highly resilient state-of-the-art technology, which we explain in the paper, finishing by giving a security, dependability and resilience analysis, showing how it meets the defined requirements, even while the infrastructure is under attack. [less ▲] Detailed reference viewed: 82 (5 UL)![]() Camino, Ramiro Daniel ![]() ![]() ![]() E-print/Working paper (2020) Detailed reference viewed: 62 (6 UL)![]() ![]() Reckinger, Rachel ![]() E-print/Working paper (2020) Moments of crisis like the current one sparked by Covid-19, engage social, economic, cultural and political institutions of a society and stress-test their resourcefulness, while individual and collective ... [more ▼] Moments of crisis like the current one sparked by Covid-19, engage social, economic, cultural and political institutions of a society and stress-test their resourcefulness, while individual and collective food supplies become primary concerns. Where does even the wealthiest of EU member States stand when it comes to food sovereignty and specific vulnerabilities, what needs to change and which food policies are needed to facilitate a sustainable food system – both locally and internationally? Combining qualitative, empirical research methods to textual and statistical analysis, as well as transformative research, I focus on key areas of Luxembourg’s food system presenting challenges – specific ones and structural ones intertwined with issues in other countries – and discuss current and planned pathways of optimisation. I will start out with an analysis of agricultural and commercial specificities of a food system with low self-sufficiency rates, linked to meat and dairy specialisations, but also to market accessibility and market structure issues, leading to heavy imports. I will then shed light on pathways currently put into practice by the State, by economic actors, by educational actors and by social movements and coalitions of the willing, advocating ecological, ethical and qualitative production methods. Finally, I will show how the first Food Policy Council at national level that Luxembourg is currently founding is favoring a deliberate shift towards a multi-stakeholder-lead effective food policy. [less ▲] Detailed reference viewed: 43 (4 UL)![]() Pinto Gouveia, Ines ![]() ![]() ![]() E-print/Working paper (2020) Today, leveraging the enormous modular power, diversity and flexibility of manycore systems-on-a-chip (SoCs) requires careful orchestration of complex resources, a task left to low-level software, e.g ... [more ▼] Today, leveraging the enormous modular power, diversity and flexibility of manycore systems-on-a-chip (SoCs) requires careful orchestration of complex resources, a task left to low-level software, e.g. hypervisors. In current architectures, this software forms a single point of failure and worthwhile target for attacks: once compromised, adversaries gain access to all information and full control over the platform and the environment it controls. This paper proposes Midir, an enhanced manycore architecture, effecting a paradigm shift from SoCs to distributed SoCs. Midir changes the way platform resources are controlled, by retrofitting tile-based fault containment through well known mechanisms, while securing low-overhead quorum-based consensus on all critical operations, in particular privilege management and, thus, management of containment domains. Allowing versatile redundancy management, Midir promotes resilience for all software levels, including at low level. We explain this architecture, its associated algorithms and hardware mechanisms and show, for the example of a Byzantine fault tolerant microhypervisor, that it outperforms the highly efficient MinBFT by one order of magnitude. [less ▲] Detailed reference viewed: 256 (35 UL)![]() Lehnert, Thorsten ![]() E-print/Working paper (2020) I evaluate Christine Lagarde´s claim that more female leaders can be associated with more prudence, and less of the risky decision-making that had provoked the crisis. Indeed, the proportion of women who ... [more ▼] I evaluate Christine Lagarde´s claim that more female leaders can be associated with more prudence, and less of the risky decision-making that had provoked the crisis. Indeed, the proportion of women who are employed in decision-making and management roles in governments, large enterprises and institutions varies substantially across European countries and is oftentimes below 30%. Research suggests that in addition to biological differences, men and women show morphological dissimilarities in specific brain regions, which explain the observed differences in behavior. As a result, female decision makers tend to be more risk averse, better suited to carefully analyze a problem, superior in multitasking and better in creating solutions that work for a group. Not surprisingly, firms with more female decision makers tend to outperform their peers in terms of productivity, profitability and stock performance while taking fewer risks. In this paper, I aim to explore the effect of female decision making on aggregate equity returns. Relying on an equilibrium asset-pricing model in an economy under jump diffusion, I decompose the moments of the returns of European stock market indices into a diffusive (systematic) risk and an (idiosyncratic) extreme event risk part. For a balanced panel of European countries, I find empirical evidence for a Lehman sisters’ effect: female decision making is an important determinant of (idiosyncratic) extreme event risk. As a result, stock markets in countries with more female decision makers are characterized by higher risk aversion, lower volatility and more positive return asymmetry, primarily driven by extreme event risk, e.g. the lower frequency of negative jumps. Results are robust to the inclusion of various controls for other country- or market-specific characteristics. [less ▲] Detailed reference viewed: 77 (4 UL)![]() ; ; et al E-print/Working paper (2020) Detailed reference viewed: 57 (0 UL)![]() Lehnert, Thorsten ![]() E-print/Working paper (2020) Detailed reference viewed: 120 (3 UL)![]() Scheuer, Claude ![]() ![]() E-print/Working paper (2020) Dans le cadre du projet BMC-EU (Compétences motrices de base en Europe), une boîte à outils pour la formation des enseignants reprenant le concept de formation ainsi qu’un manuel d'utilisation (BMC-EU ... [more ▼] Dans le cadre du projet BMC-EU (Compétences motrices de base en Europe), une boîte à outils pour la formation des enseignants reprenant le concept de formation ainsi qu’un manuel d'utilisation (BMC-EU production intellectuelle 4) a été développée afin de soutenir la mise en œuvre de la formation aux tests MOBAK (boîte à outils pour l’enseignant-support théorique) la base du concept de compétences motrices de base (BMC-EU production intellectuelle 3 ; Scheuer & Heck, 2020). L'objectif de cette boîte à outils de soutien est d'être mis en œuvre principalement au niveau des cours réguliers d'éducation physique pour aider les enseignants d’éducation physique à adapter leurs contenus et leurs méthodes d'enseignement. La boîte à outils pour la formation des enseignants présente les éléments à mettre en œuvre lors de formations d'enseignants. Celles-ci sont structurées en une partie théorique et une partie pratique. Dans un premier temps, les enseignants sont familiarisés avec le concept MOBAK, la mesure, la procédure de test, le traitement des données et l’évaluation ainsi qu'avec l'interprétation des résultats du test. Dans une deuxième partie, ils apprennent à passer du diagnostic des compétences motrices de base des élèves et des forces et faiblesses identifiées dans l'évaluation à des interventions concrètes en utilisant le cadre de soutien MOBAK et les documents qui l'accompagnent sous la forme d'un support théorique (boîte à outils pour l’enseignant), prêt à être mis en œuvre dans des situations éducatives concrètes pour soutenir les élèves ayant des besoins supplémentaires en compétences motrices de base. Étant donné que la boîte à outils pour la formation des enseignants vise à soutenir et à faciliter la mise en œuvre de la formation théorique des enseignants de soutien modulaire pour les enseignants (Scheuer et Heck, 2020), il sera fait référence au concept et au construit des tests MOBAK (Herrmann, 2018), et au manuel de test MOBAK tout au long de ce document. [less ▲] Detailed reference viewed: 88 (3 UL)![]() Scheuer, Claude ![]() ![]() E-print/Working paper (2020) No quadro do projeto BMC-EU (Competências motoras básicas na Europa), foi desenvolvida um kit modular de ferramentas de suporte para os professores para o desenvolvimento das competências motoras básicas ... [more ▼] No quadro do projeto BMC-EU (Competências motoras básicas na Europa), foi desenvolvida um kit modular de ferramentas de suporte para os professores para o desenvolvimento das competências motoras básicas, baseado nos resultados da colheita de dados realizada na fase 1 do projeto, como parte do seu output intelectual 3. O objetivo deste kit de ferramentas é ser implementado principalmente ao nível das aulas regulares de Educação Física, para apoiar as decisões dos professores em relação ao conteúdo e aos métodos no ensino de Educação Física. Numa primeira etapa, a estrutura de suporte foi desenvolvida para permitir avaliar e realizar o diagnóstico das competências motoras básicas dos alunos nos seus pontos fortes e fracos, e apoiar intervenções concretas. Como base dessa estrutura, foram desenvolvidos folhetos de suporte sob a forma de um kit modular de ferramentas de suporte, prontos para serem implementados em situações educacionais concretas, para apoiar o desenvolvimento de algumas competências básicas dos alunos. O kit modular de ferramentas de suporte inclui as diretrizes para a interpretação dos resultados dos testes MOBAK (Motorische Basiskompetenzen; expressão alemã para competências motoras básicas), que são a estrutura de suporte do MOBAK, um glossário, bem como o kit modular de ferramentas de suporte com materiais para professores de Educação Física sob a forma de cartões com a descrição das tarefas do forma de MOBAK e de cartões de atividade MOBAK baseados em princípios da variação e de uma abordagem por competências. [less ▲] Detailed reference viewed: 48 (0 UL)![]() Scheuer, Claude ![]() ![]() E-print/Working paper (2020) In the frame of the BMC-EU project (Basic motor competencies in Europe), a teacher training toolkit consisting of a teacher training concept with an accompanying user manual (BMC-EU intellectual output 4 ... [more ▼] In the frame of the BMC-EU project (Basic motor competencies in Europe), a teacher training toolkit consisting of a teacher training concept with an accompanying user manual (BMC-EU intellectual output 4) was developed in order to support the implementation of the modular support toolkit on the basis of the concept of basic motor competences (BMC-EU intellectual output 3; Scheuer & Heck, 2020). The aim of this support toolkit is to be implemented mainly at the level of regular physical education lessons to initiate adaptations regarding the content and methods in physical education instruction. The teacher training toolkit contains materials to implement teacher trainings structured in a theoretical and a practical part. In a first step, teachers are familiarized with the MOBAK concept, measurement, test procedure, data procession and evaluation as well as with the interpretation of test results. In a second part, they learn how to get from the diagnosis of the students’ basic motor competencies and the strengths and weaknesses identified in the assessment to concrete interventions by using the MOBAK support framework and the accompanying supportive handouts in form of a modular support toolkit, ready to be implemented in concrete educational situations to support students with additional needs in basic motor competencies. As the teacher training toolkit aims to support and facilitate the implementation of the Modular support toolkit for teachers (Scheuer & Heck, 2020) based on the MOBAK concept and measurement (Herrmann, 2018), reference to the support toolkit and the MOBAK Test manual is given throughout this document [less ▲] Detailed reference viewed: 61 (10 UL)![]() Scheuer, Claude ![]() ![]() E-print/Working paper (2020) V rámci projektu BMC-EU (Základní pohybové kompetence v Evropě) byl na základě koncepce základních pohybových kompetencí a výsledků sběru dat vytvořen rámec podpory a vzorová sada nástrojů (výsledek první ... [more ▼] V rámci projektu BMC-EU (Základní pohybové kompetence v Evropě) byl na základě koncepce základních pohybových kompetencí a výsledků sběru dat vytvořen rámec podpory a vzorová sada nástrojů (výsledek první fáze projektu – intelektuální výstup 3). Účelem této sady je nabídnout variabilní přístup k metodice tělesné výchovy. V první fázi projektu byl vytvořen podpůrný rámec pro diagnostiku základních pohybových kompetencí žáků, jejich silných a slabých stránek z pohledu základních pohybových způsobilostí. Na základě tohoto rámce byly vyvinuty podklady ve formě vzorové podpůrné sady (didaktických) materiálů, připravených k implementaci v konkrétních vzdělávacích situacích, jejichž účelem je rozvoj základních pohybových kompetencí diagnostikovaných žáků. Vzorová podpůrná sada nástrojů obsahuje pokyny pro interpretaci výsledků testů MOBAK (Motorische Basiskompetenzen), podpůrný rámec MOBAK, glosář a vzorovou podpůrnou sadu nástrojů s materiály pro učitele tělesné výchovy ve formě karet MOBAK. Karty MOBAK popisují činnosti a aktivity dle principů variace (rozličnosti podnětů) a jsou založeny na přístupu orientovaném na kompetence. [less ▲] Detailed reference viewed: 32 (0 UL)![]() Scheuer, Claude ![]() ![]() E-print/Working paper (2020) In het kader van het BMC-EU-project (Basismotorische competentie in Europa) is een toolkit voor de training van docenten en een toolkit voor de brede motorische ontwikkeling ontwikkeld. Dit is ontwikkeld ... [more ▼] In het kader van het BMC-EU-project (Basismotorische competentie in Europa) is een toolkit voor de training van docenten en een toolkit voor de brede motorische ontwikkeling ontwikkeld. Dit is ontwikkeld op basis van het concept basismotorische competenties en de resultaten van de gegevensverzameling in fase 1 van het project als onderdeel van intellectuele output 3. Het doel van deze toolkit is om de inhoud en methoden van de reguliere lessen lichamelijke opvoeding aan te passen aan de (motorische) behoeften van de kinderen. In een eerste stap is het hulpaanbod ontwikkeld. Dit is ontwikkeld op basis van de diagnose van de motorische basiscompetenties van de kinderen en de sterke en zwakke punten die bij de beoordeling zijn geïdentificeerd. Dit vormde het raamwerk voor de ondersteunende hand-outs in deze toolkit. De toolkit kan direct geïmplementeerd worden in concrete onderwijssituaties. Kinderen met aanvullende behoeften in basismotorische competenties kunnen hiermee worden ondersteund. De toolkit bevat verschillende onderdelen: - Richtlijnen voor de interpretatie van MOBAK-testresultaten (Motorische Basiskompetenzen; Duits voor basismotorische competenties). - De MOBAK-toolkit. - Een verklarende woordenlijst. - De modulaire supporttoolkit met materiaal voor leraren lichamelijke opvoeding in de vorm van MOBAK activiteiten-kaarten. - MOBAK-activiteitenkaarten gebaseerd op variatieprincipes en op een competentiegerichte aanpak. [less ▲] Detailed reference viewed: 542 (0 UL)![]() Scheuer, Claude ![]() ![]() E-print/Working paper (2020) In het kader van het BMC-EU project (Basismotorische competenties in Europa) heeft men op basis van het concept van basismotorische competenties (BMC-EU intellectuele output), een toolkit voor de training ... [more ▼] In het kader van het BMC-EU project (Basismotorische competenties in Europa) heeft men op basis van het concept van basismotorische competenties (BMC-EU intellectuele output), een toolkit voor de training van docenten ontwikkeld met daarbij een bijbehorende gebruikershandleiding. Het doel van deze toolkit is voornamelijk om op het niveau van de reguliere lessen lichamelijke opvoeding aanpassingen te initiëren die van toepassing zijn op de inhoud en methoden in de lichamelijke opvoeding. De training voor docenten is opgedeeld in een praktisch en theoretisch deel. Allereerst worden leraren vertrouwd gemaakt met het MOBAK concept, de meting, testprocedure, de gegevensverwerking en evaluatie, evenals met de interpretatie van de testresultaten. In een tweede deel leren ze hoe ze van de diagnose van de basismotorische competenties van studenten en de sterke en zwakke punten die bij de beoordeling zijn geïdentificeerd, kunnen komen tot concrete interventies. Dit kan door het MOBAK kader en de bijbehorende hand-outs te gebruiken in de vorm van een modulaire ondersteunende toolkit. Deze toolkit kan ingezet worden in concrete onderwijssituaties om kinderen met aanvullende behoeften in basismotorische competenties te ondersteunen. Aangezien de training voor docenten de uitvoering van de toolkit voor de brede motorische ontwikkeling (Scheuer & Heck, 2020), gebaseerd op het MOBAK-concept en meting (Herrmann, 2018), wil ondersteunen en vergemakkelijken, wordt in dit document verwezen naar de ondersteunende toolkit en de MOBAK-testhandleiding. [less ▲] Detailed reference viewed: 138 (2 UL)![]() Scheuer, Claude ![]() ![]() E-print/Working paper (2020) No enquadramento do projeto BMC-EU (Competências motoras básicas na Europa), a ferramenta para a formação de professores consistindo num conceito de formação de professores juntamente com um manual de ... [more ▼] No enquadramento do projeto BMC-EU (Competências motoras básicas na Europa), a ferramenta para a formação de professores consistindo num conceito de formação de professores juntamente com um manual de utilização (BMC-EU intellectual output 4) foi desenvolvido de modo a apoiar a implementação do kit modular de ferramentas para suporte aos professores considerando o conceito de competências motoras básicas (BMC-EU intellectual output 3; Scheuer & Heck, 2020). O objetivo deste kit de ferramentas de suporte é ser implementado principalmente ao nível da educação física regular para iniciar adaptações relativas ao conteúdo e métodos na instrução da educação física. A ferramenta de apoio à formação de professores contém materiais para implementar a formação de professores estruturada, com uma parte teórica e outra prática. Num primeiro passo, os professores estão familiarizados com o conceito MOBAK, medição, procedimentos do teste, tratamento dos dados e avaliação assim como com a interpretação dos resultados do teste. Numa segunda parte eles aprendem como diagnosticar as competências motoras básicas dos alunos e as forças e fraquezas identificadas na avaliação para concretizar intervenções usando o quadro de referência de suporte MOBAK e as fichas que acompanham o Kit de suporte, prontos para serem implementados em situações educativas concretas para apoiar estudantes com necessidades acrescidas nas competências motoras básicas. Como a ferramenta para a formação de professores visa apoiar e facilitar a implementação do Kit modular de ferramentas para suporte aos professores (Scheuer & Heck, 2020) baseado no conceito e medição do MOBAK (Herrmann, 2018), ao longo deste manual são fornecidas referências para suportar o kit de apoio e o manual do teste MOBAK . [less ▲] Detailed reference viewed: 73 (4 UL)![]() Scheuer, Claude ![]() ![]() E-print/Working paper (2020) V rámci projektu BMC-EU (Základné pohybové kompetencie v Európe) bol vytvorený súbor nástrojov odbornej prípravy učiteľov pozostávajúci z koncepcie odbornej prípravy učiteľov so sprievodným návodom na ... [more ▼] V rámci projektu BMC-EU (Základné pohybové kompetencie v Európe) bol vytvorený súbor nástrojov odbornej prípravy učiteľov pozostávajúci z koncepcie odbornej prípravy učiteľov so sprievodným návodom na použitie (intelektuálny výstup BMC-EU 4), s cieľom podporiť využitie podporného metodického materiálu na základe koncepcie základných pohybových kompetencií (intelektuálny výstup BMC-EU 3; Scheuer & Heck, 2020). Cieľom tohto podporného materiálu je iniciovať na úrovni pravidelných hodín telesnej a športovej výchovy úpravy týkajúce sa obsahu a metód výučby telesnej a športovej výchovy. Nástroj pre školenie učiteľov obsahuje materiály na realizáciu školení učiteľov štruktúrovaných v teoretickej a praktickej časti. V prvom kroku sú učitelia oboznámení s koncepciou MOBAK, meraním, testovacím postupom, spracovaním a vyhodnotením údajov, ako aj s interpretáciou výsledkov testov. V druhej časti sa naučia, ako získať informácie z diagnostiky základných pohybových kompetencií žiakov a ich silných a slabých stránok identifikovaných pri hodnotení. Tiež sa naučia pracovať s pomocou podporného rámca MOBAK a sprievodných podporných nástrojov vo forme podpornej metodickej príručky, pripravenej na implementáciu v konkrétnych vzdelávacích situáciách na podporu žiakov s ďalšími potrebami v základných pohybových kompetenciách. Keďže cieľom súboru nástrojov prípravy učiteľov je podporiť a uľahčiť implementáciu metodickej príručky pre učiteľov (Scheuer & Heck, 2020) založenej na koncepte a meraní MOBAK (Herrmann, 2018), odkaz na podpornú metodickú príručku MOBAK je uvedený v tomto dokumente. [less ▲] Detailed reference viewed: 56 (4 UL)![]() Scheuer, Claude ![]() ![]() E-print/Working paper (2020) Vykdant BMC-EU projektą "Basic motor competencies in Europe" buvo sukurta mokytojų rengimo priemonė, susidedanti iš mokytojų rengimo sampratos ir vartotojo vadovo (BMC-EU intelektinės veiklos rezultatas ... [more ▼] Vykdant BMC-EU projektą "Basic motor competencies in Europe" buvo sukurta mokytojų rengimo priemonė, susidedanti iš mokytojų rengimo sampratos ir vartotojo vadovo (BMC-EU intelektinės veiklos rezultatas Nr. 4), kurios tikslas - remiantis motorinių kompetencijų koncepcija padėti įgyvendinti modulinę palaikymo priemonę (BMC-EU intelektinės veiklos rezultatas Nr. 3; Scheuer ir Heck, 2020). Palaikymo priemonė skirta įprastoms kūno kultūros pamokoms, kurių metu skatinami turinio ir metodų pokyčiai ir jų taikymai. Mokytojų rengimo priemonėje pateikiama teorinė ir praktinė medžiaga. Pirmiausia mokytojai supažindinami su MOBAK koncepcija, matavimais, testavimo procedūra, duomenų apdorojimu ir vertinimu bei rezultatų aiškinimu. Antroje dalyje paaiškinama, kaip turimas žinias apie pagrindines moksleivių motorines kompetencijas ir vertinant išryškėjusias jų stipriąsias bei silpnąsias puses panaudoti praktiškai taikant MOBAK paramos sistemą ir kitą pagalbinę medžiagą konkrečiose mokymo situacijose atsižvelgiant į moksleivių poreikius ir pagrindines motorines kompetencijas. Kadangi mokytojų rengimo priemone siekiama palengvinti modulinės palaikymo priemonės mokytojams (Scheuer & Heck, 2020) įgyvendinimą remiantis MOBAK koncepcija ir matavimais (Herrmann, 2018), leidinyje dažnai mnima paramos sistema ir MOBAK vadovas. [less ▲] Detailed reference viewed: 52 (0 UL)![]() Scheuer, Claude ![]() ![]() E-print/Working paper (2020) Im Rahmen des BMC-EU Projekts (Basic Motor Competencies in Europe) wurde ein Toolkit für die Fortbildung von Sportlehrkräften entwickelt, welches aus einem Fortbildungskonzept inklusive eines Handbuchs ... [more ▼] Im Rahmen des BMC-EU Projekts (Basic Motor Competencies in Europe) wurde ein Toolkit für die Fortbildung von Sportlehrkräften entwickelt, welches aus einem Fortbildungskonzept inklusive eines Handbuchs (BMC-EU intellectual output 4) besteht. Die Entwicklung dieses Fortbildungskonzepts soll dazu beitragen, dass das modulare Support Toolkit auf der Basis des Konzepts der motorischen Basiskompetenzen (BMC-EU intellectual output 3; Scheuer & Heck, 2020) eingesetzt wird. Das Ziel dieses Support Toolkits ist hauptsächlich der Einsatz auf der Ebene des regulären Sportunterrichts um die Anpassungen, welche den Inhalt und die Methoden des Unterrichtens betreffen, voranzutreiben. Das Toolkit für die Fortbildung von Lehrkräften beinhaltet Materialen, die für die Durchführung einer strukturierten Lehrerfortbildung sowohl im theoretischen als auch im praktischen Teil benötigt werden. Im ersten Schritt werden die Lehrkräfte mit dem MOBAK Konzept, der Datenerhebung, der Testdurchführung, der Datenverarbeitung und –evaluation sowie mit der Interpretation der Testergebnisse vertraut gemacht. Im zweiten Schritt lernen die Lehrkräfte wie sie auf die Stärken und Schwächen ihrer Schülerinnen und Schüler, welche die Ergebnisse aus den Tests zu den motorischen Basiskompetenzen zeigen, fördern können, indem sie das MOBAK Support Toolkit verwenden. Dieses Toolkit kann direkt in konkrete Unterrichtsszenarien eingesetzt werden, um die Schülerinnen und Schüler mit zusätzlichem Förderbedarf in den motorischen Kompetenzen zu unterstützen. Da das Toolkit für die Fortbildung von Lehrkräfte darauf abzielt, die Durchführung des modularen Support Toolkits für Lehrkräfte (Scheuer & Heck, 2020) basierend auf dem MOBAK Konzept (Herrmann, 2018) zu unterstützen und zu ermöglichen, wird in diesem Dokument immer wieder auf das Support Toolkit und das MOBAK Testmanual verwiesen. [less ▲] Detailed reference viewed: 93 (5 UL)![]() Scheuer, Claude ![]() ![]() E-print/Working paper (2020) V rámci projektu BMC-EU (Základní pohybové kompetence v Evropě) byla vyvinuta sada nástrojů pro školení učitelů, skládající se z koncepce školení učitelů a doprovodné uživatelské příručky (intelektuální ... [more ▼] V rámci projektu BMC-EU (Základní pohybové kompetence v Evropě) byla vyvinuta sada nástrojů pro školení učitelů, skládající se z koncepce školení učitelů a doprovodné uživatelské příručky (intelektuální výstup BMC-EU 4) za účelem podpory implementace modulární podpůrné sady nástrojů na základě konceptu základních pohybových kompetencí (intelektuální výstup BMC-EU 3; Scheuer & Heck, 2020). Cílem této podpůrné sady nástrojů je zavedení do praxe především na úrovni pravidelných hodin tělesné výchovy tak, aby bylo možno začít s přizpůsobováním obsahu a metod výuky tělesné výchovy. Sada nástrojů pro školení učitelů obsahuje materiály pro realizaci školení rozdělené do teoretické a praktické části. V první části jsou učitelé seznámeni s konceptem MOBAK, měřením, testovacím postupem, zpracováním a vyhodnocováním dat a s interpretací výsledků testů. Ve druhé části se naučí, jak dospět od diagnostiky základních pohybových kompetencí studentů a od silných a slabých stránek identifikovaných při hodnocení k tomu, jak konkrétně zasáhnout pomocí podpůrného rámce MOBAK a doprovodných podpůrných materiálů ve formě modulární podpůrné sady nástrojů, která je připravena k zavádění do praxe v konkrétních vzdělávacích situacích za účelem podpory studentů s dalšími potřebami v základních pohybových kompetencích. Vzhledem k tomu, že sada nástrojů pro školení učitelů má za cíl podporovat a usnadňovat implementaci Modulární podpůrné sady pro učitele (Scheuer & Heck, 2020) založenou na konceptu a měření MOBAK (Herrmann, 2018), v celém tomto dokumentu se na podpůrnou sadu nástrojů a na testovací příručku MOBAK odkazuje. [less ▲] Detailed reference viewed: 36 (0 UL)![]() Scheuer, Claude ![]() ![]() E-print/Working paper (2020) Στο πλαίσιο του έργου BMC-EU (Βασικές Κινητικές Δεξιότητες στην Ευρώπη), αναπτύχθηκε μία εργαλειοθήκη κατάρτισης για εκπαιδευτικούς, αποτελούμενη από τη γενική πρακτική ιδέα και ένα συνοδευτικό εγχειρίδιο ... [more ▼] Στο πλαίσιο του έργου BMC-EU (Βασικές Κινητικές Δεξιότητες στην Ευρώπη), αναπτύχθηκε μία εργαλειοθήκη κατάρτισης για εκπαιδευτικούς, αποτελούμενη από τη γενική πρακτική ιδέα και ένα συνοδευτικό εγχειρίδιο χρήστη (BMC-EU πνευματική παραγωγή 4), για να υποστηρίξει την εφαρμογή της υποστηρικτικής εργαλειοθήκης με βάση την έννοια των βασικών κινητικών δεξιοτήτων (BMC-EU πνευματική παραγωγή 3; Scheuer & Heck, 2020). Ο σκοπός της εργαλειοθήκης αυτής είναι να εφαρμοστεί στα μαθήματα φυσικής αγωγής, ώστε να προσαρμοστούν κατάλληλα τόσο το περιεχόμενο όσο και οι μέθοδοι διδασκαλίας της φυσικής αγωγής. Η εργαλειοθήκη κατάρτισης για εκπαιδευτικούς περιέχει υλικό για τη δημιουργία πρακτικών προγραμμάτων για εκπαιδευτικούς δομημένα τόσο σε θεωρητικό, όσο και πρακτικό επίπεδο. Αρχικά, οι εκπαιδευτικοί εξοικειώνονται με την έννοια του ΜΟΒΑΚ, τις μετρήσεις, τη διαδικασία της εξέτασης, την επεξεργασία των δεδομένων και την αξιολόγηση, καθώς και με την ερμηνεία των αποτελεσμάτων. Στη συνέχεια, μαθαίνουν πώς να μεταβούν από τη διάγνωση των βασικών κινητικών δεξιοτήτων και τον εντοπισμό των αντίστοιχων ικανοτήτων των μαθητών, στον σχεδιασμό και την υλοποίηση συγκεκριμένων παρεμβάσεων με τη χρήση του υποστηρικτικού πλαισίου ΜΟΒΑΚ και των συνοδευτικών υποστηρικτικών φυλλαδίων, που είναι έτοιμα προς εφαρμογή σε συγκεκριμένες εκπαιδευτικές συνθήκες για την υποστήριξη μαθητών με πρόσθετες ανάγκες στις βασικές κινητικές δεξιότητες. Η εργαλειοθήκη κατάρτισης για εκπαιδευτικούς έχει ως σκοπό να υποστηρίξει και να διευκολύνει την εφαρμογή της Υποστηρικτικής εργαλειοθήκης για εκπαιδευτικούς (Scheuer & Heck, 2020), που βασίζεται στην έννοια και τις μετρήσεις ΜΟΒΑΚ (Herrmann, 2018). [less ▲] Detailed reference viewed: 54 (1 UL)![]() Scheuer, Claude ![]() ![]() E-print/Working paper (2020) Nell’ambito del progetto BMC-EU (Competenze motorie di base in Europa), è stato sviluppato un ulteriore documento utile alla formazione degli insegnanti, che consiste in un manuale di formazione (output ... [more ▼] Nell’ambito del progetto BMC-EU (Competenze motorie di base in Europa), è stato sviluppato un ulteriore documento utile alla formazione degli insegnanti, che consiste in un manuale di formazione (output intellettuale BMC-EU 4), al fine di implementare il manuale modulare riguardante le competenze motorie di base (produzione intellettuale BMC-EU 3; Scheuer & Heck, 2020). Lo scopo di questo manuale è quello di ampliare i contenuti delle lezioni curriculari di educazione fisica, per proporre gli adattamenti riguardanti le attività ed i metodi. Il manuale contiene i materiali per implementare il processo di formazione degli insegnanti ed è strutturato in una parte teorica e una pratica. In una prima parte, gli insegnanti acquisiscono familiarità con la struttura del MOBAK, la misurazione, l’attuazione delle prove, l’elaborazione e e la valutazione dei dati, nonché con l'interpretazione dei risultati delle prove. In una seconda parte, imparano ad acquisire informazioni sulle competenze motorie di base degli allievi e sui punti di forza e di debolezza identificati nella valutazione. Inoltre, mediante proposte operative presenti nel manuale modulare del MOBAK e negli allegati, è possibile implementare i contesti di apprendimento per sostenere gli allievi con bisogni educativi speciali nelle competenze motorie di base. Il presente manuale per la formazione degli insegnanti è finalizzato a sostenere ed integrare il manuale modulare (Scheuer & Heck, 2020), basato sulla struttura e sui livelli del MOBAK (Herrmann, 2018). [less ▲] Detailed reference viewed: 38 (0 UL)![]() Golebiewska, Anna ![]() E-print/Working paper (2020) Patient-derived cancer models are essential tools for studying tumor biology and preclinical interventions. Here, we show that glioma patient-derived orthotopic xenografts (PDOXs) enable long-term ... [more ▼] Patient-derived cancer models are essential tools for studying tumor biology and preclinical interventions. Here, we show that glioma patient-derived orthotopic xenografts (PDOXs) enable long-term propagation of patient tumors and represent clinically relevant patient avatars. We created a large collection of PDOXs from primary and recurrent gliomas with and without mutations in IDH1, which retained histopathological, genetic, epigenetic and transcriptomic features of patient tumors with no mouse-specific clonal evolution. Longitudinal PDOX models recapitulate the limited genetic evolution of gliomas observed in patient tumors following treatment. PDOX-derived standardized tumor organoid cultures enabled assessment of drug responses, which were validated in mice. PDOXs showed clinically relevant responses to Temozolomide and to targeted treatments such as EGFR and CDK4/6 inhibitors in (epi)genetically defined groups, according to MGMT promoter and EGFR/CDK status respectively. Dianhydrogalactitol, a bifunctional alkylating agent, showed promising potential against glioblastoma. Our study underlines the clinical relevance of glioma PDOX models for translational research and personalized treatment studies. [less ▲] Detailed reference viewed: 152 (8 UL)![]() Scheuer, Claude ![]() ![]() E-print/Working paper (2020) Un cadre théorique de soutien et une boite à outil pédagogique ont été développés dans le cadre du projet BMC-EU (Compétences motrices de base en Europe). Ces documents ont été conçus en tenant compte du ... [more ▼] Un cadre théorique de soutien et une boite à outil pédagogique ont été développés dans le cadre du projet BMC-EU (Compétences motrices de base en Europe). Ces documents ont été conçus en tenant compte du concept des compétences motrices de base ainsi que des données collectées dans la phase expérimentale (phase 1) du projet. Ils correspondent à l’étape de production intellectuelle n°3. Le cette boîte à outils s’applique principalement dans le cadre des cours d’éducation physique et offre une approche pédagogique permettant d’initier des adaptations de méthode et de contenu pertinentes dans le contexte d’enseignement de l’éducation physique à l’école primaire. Dans la première partie du document, il est expliqué comment passer du diagnostic des compétences motrices de base des élèves, de l’identification de leurs forces et faiblesses à une intervention concrètes et adaptée. Des supports documentaires sous la forme d'une boîte à outils de soutien pédagogique ont été développés dans le respect du cadre théorique de base. Ces supports ont été développés afin d’être facilement être mis en œuvre dans des situations éducatives concrètes visant à soutenir les élèves présentant des faiblesses au niveau de certaines compétences motrices de base. La boîte à outils pour l’enseignant comprend des directives pour l'interprétation des résultats des tests MOBAK (Motorische Basiskompetenzen; traduction allemande pour les compétences motrices de base), le cadre théorique MOBAK, un glossaire, ainsi que la boîte à outils de soutien pédagogique avec du matériel pour les enseignants d'éducation physique sous la forme de fiches décrivant les tests MOBAK et de fiches d'activités MOBAK basées sur des principes de variation des composantes de coordination et sur une approche axée sur le développement des compétences. [less ▲] Detailed reference viewed: 90 (6 UL)![]() Scheuer, Claude ![]() ![]() E-print/Working paper (2020) Vykdant BMC-EU projektą (Pagrindinės motorinės kompetencijos Europoje), buvo sukurta naudojimosi pagalbos ir pagalbos priemonių rinkinys, pagrįstas pagrindinių motorinių kompetencijų koncepcija ir duomenų ... [more ▼] Vykdant BMC-EU projektą (Pagrindinės motorinės kompetencijos Europoje), buvo sukurta naudojimosi pagalbos ir pagalbos priemonių rinkinys, pagrįstas pagrindinių motorinių kompetencijų koncepcija ir duomenų rinkimo rezultatais pirmame projekto etape, ir kuris yra dalis trečio intelektinio produkto. Šiuo priemonių rinkiniu siekiama paskatinti jį įgyvendinti, ypatingai per reguliarias fizinio ugdymo pamokas, adaptuojant prie fizinio ugdymo mokymo turinio ir metodų. Pirmame etape buvo sukurta pagalbos sistema, skirta mokinių pagrindinių motorinių kompetencijų įvertinimui ir siekiant įvertinimo metu nustatyti stipriosioms ir silpnosioms pusėms. Remiantis šia sistema, buvo sukurti pagalbos priemonių rinkiniai, paruošti diegti konkrečiose ugdymo situacijose, kad būtų naudingi mokiniams, kuriems reikia pagalbos vystant pagrindinius motorinius įgūdžius. Pagalbos priemonių rinkinį sudaro MOBAK (pagrindinės motorinės kompetencijos) testų rezultatų aiškinimo gairės, MOBAK paramos sistema, žodynėlis, taip pat pagalbos priemonių rinkinys, apimantis priemones fizinio ugdymo mokytojams, MOBAK užduočių aprašymo kortelės ir MOBAK veiklų kortelės su fizinių veiklų variacijomis, remiantis į kompetenciją orientuotu požiūriu. [less ▲] Detailed reference viewed: 104 (1 UL)![]() Scheuer, Claude ![]() ![]() E-print/Working paper (2020) Nell’ambito del progetto BMC-EU (Competenze motorie di base in Europa), è stato sviluppato un manuale modulare e un allegato riguardante le competenze motorie di base e ai risultati della raccolta dei ... [more ▼] Nell’ambito del progetto BMC-EU (Competenze motorie di base in Europa), è stato sviluppato un manuale modulare e un allegato riguardante le competenze motorie di base e ai risultati della raccolta dei dati nella fase 1 del progetto come parte dell’analisi dei risultati nella fase 3. Lo scopo di questo allegato è quello di fungere da strumento per implementare principalmente le lezioni di educazione fisica curriculari, consentendo gli adattamenti dei contenuti e dei metodi in educazione fisica. In una prima fase, è stato sviluppato il framework per ottenere la diagnosi delle competenze motorie di base degli allievi e conoscere i punti di forza e di debolezza identificati nella valutazione attraverso interventi concreti. A tal proposito, sono stati realizzati dei documenti sotto forma di un kit e di un manuale, pronti per essere utilizzati in situazioni didattiche concrete, per sostenere gli allievi con bisogni educativi speciali nelle competenze motorie di base. Il manuale modulare include le linee guida per l'interpretazione dei risultati delle prove MOBAK (Motorische Basiskompetenzen; termine tedesco per le competenze motorie di base), il manuale modulare del MOBAK, un glossario, nonché l’allegato con i materiali per gli insegnanti di educazione fisica sotto forma di scheda descrittiva del MOBAK e schede delle attività basate sui principi di variazione del compito motorio e sull’approccio didattico orientato alla competenza. [less ▲] Detailed reference viewed: 114 (3 UL)![]() Scheuer, Claude ![]() ![]() E-print/Working paper (2020) V rámci projektu BMC-EU (Základné pohybové kompetencie v Európe) bol v prvej fáze projektu na základe koncepcie základných pohybových kompetencií a výsledkov zberu údajov vypracovaný podporný rámec a ... [more ▼] V rámci projektu BMC-EU (Základné pohybové kompetencie v Európe) bol v prvej fáze projektu na základe koncepcie základných pohybových kompetencií a výsledkov zberu údajov vypracovaný podporný rámec a modulárny podporný súbor nástrojov ako súčasť intelektuálneho výstupu 3. Cieľom tohto súboru nástrojov je implementovať najmä na úrovni pravidelných hodín telesnej výchovy úpravy týkajúce sa obsahu a metód výučby telesnej výchovy. V prvom kroku sa vyvinul podporný rámec na získanie diagnostiky základných pohybových kompetencií detí a žiakov a silných a slabých stránok identifikovaných pri hodnotení až po konkrétne zásahy. Na základe tohto rámca boli vyvinuté podporné materiály vo forme modulárnej podpornej súpravy nástrojov, pripravené na implementáciu v konkrétnych vzdelávacích situáciách na podporu študentov s ďalšími potrebami v základných pohybových kompetenciách. Modulárna podporná sada nástrojov obsahuje pokyny na interpretáciu výsledkov testov MOBAK (Motorische Basiskompetenzen; nemčina pre základné motorické kompetencie), podporný rámec MOBAK, glosár, ako aj modulárnu podpornú sadu nástrojov s materiálmi pre učiteľov telesnej výchovy vo forme MOBAK, karty opisu úloh a karty aktivít MOBAK založené na princípoch variácie a na prístupe orientovanom na kompetencie. [less ▲] Detailed reference viewed: 98 (3 UL)![]() ![]() Kafteranis, Dimitrios ![]() E-print/Working paper (2020) Detailed reference viewed: 83 (1 UL)![]() ; ; et al E-print/Working paper (2020) Detailed reference viewed: 55 (1 UL)![]() Scheuer, Claude ![]() ![]() E-print/Working paper (2020) Στο πλαίσιο του έργου BMC-EU (Βασικές Κινητικές Δεξιότητες στην Ευρώπη) αναπτύχθηκε το πλαίσιο υποστήριξης και η υποστηρικτική εργαλειοθήκη βάση του μοντέλου των βασικών κινητικών δεξιοτήτων και των ... [more ▼] Στο πλαίσιο του έργου BMC-EU (Βασικές Κινητικές Δεξιότητες στην Ευρώπη) αναπτύχθηκε το πλαίσιο υποστήριξης και η υποστηρικτική εργαλειοθήκη βάση του μοντέλου των βασικών κινητικών δεξιοτήτων και των αποτελεσμάτων από τη συλλογή δεδομένων κατά τη φάση 1 του έργου, το οποίο αποτελεί μέρος της πνευματικής παραγωγής 3. Ο σκοπός της εργαλειοθήκης αυτής είναι να εφαρμοστεί στα μαθήματα φυσικής αγωγής, ώστε να προσαρμοστούν κατάλληλα τόσο το περιεχόμενο όσο και οι μέθοδοι διδασκαλίας της φυσικής αγωγής. Ως πρώτο βήμα, το υποστηρικτικό πλαίσιο αναπτύχθηκε για τη διάγνωση των βασικών κινητικών δεξιοτήτων των μαθητών, καθώς και για την αξιολόγηση των δυνατοτήτων τους, ώστε στη συνέχεια να δημιουργηθούν συγκεκριμένα παρεμβατικά προγράμματα. Με βάση το πλαίσιο αυτό, αναπτύχθηκαν υποστηρικτικά φυλλάδια με τη μορφή της υποστηρικτικής εργαλειοθήκης, έτοιμα προς εφαρμογή σε συγκεκριμένες εκπαιδευτικές συνθήκες για την υποστήριξη μαθητών με πρόσθετες ανάγκες στις βασικές κινητικές δεξιότητες. Η υποστηρικτική εργαλειοθήκη περιλαμβάνει οδηγίες για την ερμηνεία των αποτελεσμάτων του MOBAK (Motorische Basiskompetenzen; Γερμανικά για τις βασικές κινητικές δεξιότητες), το πλαίσιο υποστήριξης ΜΟΒΑΚ, ένα γλωσσάρι, καθώς και την υποστηρικτική εργαλειοθήκη με εργαλεία για καθηγητές φυσικής αγωγής υπό τη μορφή καρτών περιγραφής διαδικασιών και καρτών δραστηριοτήτων ΜΟΒΑΚ, βασισμένα στις αρχές της παραλλαγής των δραστηριοτήτων και σε μία προσέγγιση προσανατολισμένη στις δεξιότητες. [less ▲] Detailed reference viewed: 99 (0 UL)![]() Scheuer, Claude ![]() ![]() E-print/Working paper (2020) Im Rahmen des BMC-EU-Projekts (Motorische Basiskompetenzen in Europa) wurden ein Unterstützungsrahmen und ein modulares Unterstützungs-Toolkit auf der Grundlage des Konzepts der grundlegenden motorischen ... [more ▼] Im Rahmen des BMC-EU-Projekts (Motorische Basiskompetenzen in Europa) wurden ein Unterstützungsrahmen und ein modulares Unterstützungs-Toolkit auf der Grundlage des Konzepts der grundlegenden motorischen Kompetenzen und der Ergebnisse der Datenerfassung in Phase 1 des Projekts als Teil des intellektuellen Outputs 3entwickelt. Ziel dieses Toolkits ist es, hauptsächlich auf der Ebene des regulären Sportunterrichts umgesetzt zu werden, um Anpassungen hinsichtlich der Inhalte und Methoden des Sportunterrichts einzuleiten. In einem ersten Schritt wurde der Unterstützungsrahmen entwickelt, um von der Diagnose der grundlegenden motorischen Kompetenzen der Schülerinnen und Schüler1 und der in der Bewertung identifizierten Stärken und Schwächen zu konkreten Interventionen zu gelangen. Basierend auf diesem Rahmen wurden unterstützende Handouts in Form eines modularen Support-Toolkits entwickelt, die in konkreten Bildungssituationen implementiert werden können, um Schüler mit zusätzlichen Anforderungen an motorische Basiskompetenzen zu unterstützen. Das modulare Support-Toolkit enthält Richtlinien für die Interpretation der Testergebnisse von MOBAK (Motorische Basiskompetenzen), das MOBAK-Unterstützungsrahmen, ein Glossar sowie das modulare Support-Toolkit mit Materialien für Sportlehrer in Form von MOBAK Aufgabenbeschreibungskarten und MOBAK-Aktivitätskarten basierend auf Variationsprinzipien und einem kompetenzorientierten Ansatz. [less ▲] Detailed reference viewed: 151 (3 UL)![]() Lehnert, Thorsten ![]() E-print/Working paper (2020) Detailed reference viewed: 118 (6 UL) |
||