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See detailMagnetic correlations in polycrystalline Tb0.15Co0.85
Bersweiler, Mathias UL; Bender, Philipp Florian UL; Peral Alonso, Inmaculada UL et al

in Journal of Physics: D Applied Physics (2020), 53

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See detailIntegrative omics analysis of the termite gut system adaptation to Miscanthus diet identifies lignocellulose degradation enzymes.
Calusinska, Magdalena; Marynowska, Martyna; Bertucci, Marie UL et al

in Communications Biology (2020)

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See detailConsolidated democracy advantage: political instability and sovereign spreads in the EU
Glaurdic, Josip UL; Lesschaeve, Christophe UL; Vizek, Maruška

in Comparative European Politics (2020), 18(3), 437-459

We expose the way the market evaluates internal political risk and instability in democratic polities by analysing the determinants of sovereign spreads of EU member states over the course of the past two ... [more ▼]

We expose the way the market evaluates internal political risk and instability in democratic polities by analysing the determinants of sovereign spreads of EU member states over the course of the past two decades. Our analysis builds on the “democratic advantage” argument which suggests democracies enjoy preferential treatment on the international market of sovereign debt because of their better ability to make credible commitments. We suggest that, when it comes to the market’s evaluation of internal political instability and risk in democratic polities, there actually exists a “consolidated democracy advantage”. In times of political instability, older and more consolidated democracies pay less of a premium on their debt than their younger and less consolidated counterparts. In other words, the market indeed views the commitment of consolidated democracies with long track records of democratic competition and survival as something qualitatively diferent than the commitment of new democracies with short track records. [less ▲]

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See detailCategorisation of building data in the digital documentation of heritage buildings
Khalil, Ahmed; Stravoravdis, Spyridon; Backes, Dietmar UL

in Applied Geomatics (2020)

The documentation of heritage buildings is the preliminary action to deal with any problem related to the built heritage. The procedure of documentation requires a very diverse range of data (quantitative ... [more ▼]

The documentation of heritage buildings is the preliminary action to deal with any problem related to the built heritage. The procedure of documentation requires a very diverse range of data (quantitative and qualitative) to be obtained and investigated in order to produce an accurate digital representation of the building. This type of work of data capture and interpretation is often conducted in isolation by different stakeholders and for a range of purposes, leading to a lack of communication between different data types, repeated effort and incomplete documentation. Heritage Building Information Modelling (H-BIM) is set to play a key role in the digital documentation of heritage buildings, as it can combine quantitative and qualitative data and facilitate the integration of different stakeholders and specialised data into the digital management of the different phases of dealing with heritage buildings. This paper aims to review the multitude of data types that could be included in the documentation and investigation process of the built heritage, in order to assess the breadth and depth by which heritage buildings can be documented. Four main categories that span the whole documentation data areas are being suggested which vary from outer geometry surveys, to subsurface materials and structural integrity investigations, to data concerning the building performance, as well as the historic records concerning the building’s morphology over time, which can help to create a more in-depth knowledge about the heritage building’s status and performance and can create a solid base for any required restoration and retrofitting processes (Khalil and Stravoravdis 2019a). [less ▲]

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See detailUnified Framework for Secrecy Characteristics with Mixture of Gaussian (MoG) Distribution
Kong, Long UL; Chatzinotas, Symeon UL; Ottersten, Björn UL

in IEEE Wireless Communications Letters (2020)

The mixture of Gaussian (MoG) distribution was proposed to model the wireless channels by implementing the completely unsupervised expectation-maximization (EM) learning algorithm. With the high ... [more ▼]

The mixture of Gaussian (MoG) distribution was proposed to model the wireless channels by implementing the completely unsupervised expectation-maximization (EM) learning algorithm. With the high convenience for density estimation applications, the focus of this letter is supposed to investigate the secrecy metrics, including secrecy outage probability (SOP), the lower bound of SOP, the probability of non-zero secrecy capacity (PNZ), and the average secrecy capacity (ASC) from the information-theoretic perspective. The above-mentioned metrics are derived with simple and unified closed-form expressions. The effectiveness of our obtained analytical expressions are successfully examined and compared with Monte-Carlo simulations. One can conclude that this letter provides a simple but effective closed-form secrecy analysis solution exploiting the MoG distribution. [less ▲]

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See detailA Comprehensive Survey on Resource Allocation for CRAN in 5G and Beyond Networks
Ejaz, Waleed; Sharma, Shree Krishna UL; Saadat, Salman et al

in Journal of Network and Computer Applications (2020)

The diverse service requirements coming with the advent of sophisticated applications as well as a large number of connected devices demand for revolutionary changes in the traditional distributed radio ... [more ▼]

The diverse service requirements coming with the advent of sophisticated applications as well as a large number of connected devices demand for revolutionary changes in the traditional distributed radio access network (RAN). To this end, Cloud-RAN (CRAN) is considered as an important paradigm to enhance the performance of the upcoming fifth generation (5G) and beyond wireless networks in terms of capacity, latency, and connectivity to a large number of devices. Out of several potential enablers, efficient resource allocation can mitigate various challenges related to user assignment, power allocation, and spectrum management in a CRAN, and is the focus of this paper. Herein, we provide a comprehensive review of resource allocation schemes in a CRAN along with a detailed optimization taxonomy on various aspects of resource allocation. More importantly, we identity and discuss the key elements for efficient resource allocation and management in CRAN, namely: user assignment, remote radio heads (RRH) selection, throughput maximization, spectrum management, network utility, and power allocation. Furthermore, we present emerging use-cases including heterogeneous CRAN, millimeter-wave CRAN, virtualized CRAN, Non- Orthogonal Multiple Access (NoMA)-based CRAN and fullduplex enabled CRAN to illustrate how their performance can be enhanced by adopting CRAN technology. We then classify and discuss objectives and constraints involved in CRAN-based 5G and beyond networks. Moreover, a detailed taxonomy of optimization methods and solution approaches with different objectives is presented and discussed. Finally, we conclude the paper with several open research issues and future directions. [less ▲]

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See detailEmerging concepts for precision medicine in Parkinson's disease with focus on genetics
Krüger, Rejko UL; Stute, Lara UL

in Fortschritte der Neurologie-Psychiatrie (2020)

The diverse and highly individual presentations of Parkinson's disease (PD) as a complex combination of motor and non-motor symptoms are being increasingly well characterised not least through large ... [more ▼]

The diverse and highly individual presentations of Parkinson's disease (PD) as a complex combination of motor and non-motor symptoms are being increasingly well characterised not least through large patient cohorts applying deep phenotyping. However, in terms of treatment of PD, the approach is uniform and purely symptomatic. Better stratification strategies with better precision medicine approaches offer opportunities to improve symptomatic treatment, define first causative therapies and provide more patient-centred care. Insight from targeted therapies for monogenic forms of PD aiming at neuroprotection may pave the way for new mechanism-based interventions also for the more common idiopathic PD. Improved stratification of patients may support symptomatic treatments by predicting treatment efficacy and long-term benefit of current pharmacological or neuromodulatory therapies, e.g. in the context of emerging pharmacogenomic knowledge. Based on asymptomatic carriers with monogenic PD or patients with REM sleep behaviour disorder (RBD), first options for applying preventive treatments emerge. The implications of these treatment strategies in relation to disease progression, and the prospects of their implementation in clinical practice need to be addressed. [less ▲]

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See detailInternet histories early career researcher award
Brügger, Niels; Goggin, Gerard; Milligan, Ian et al

in Internet Histories: Digital Technology, Culture and Society (2020)

The five papers of this special issue were candidates for the first Internet Histories Early Career Researcher Award. They represent the next generation of scholarship and show creative, original ... [more ▼]

The five papers of this special issue were candidates for the first Internet Histories Early Career Researcher Award. They represent the next generation of scholarship and show creative, original approaches to the study of internet history. These papers all help enrich our perspectives and broaden them in many ways, from Brazil to China, from Cyberactivitst to Civil Society at large, from Gender Studies to Platform Studies, from Emails to Interfaces, while demonstrating again that there is no unique path to write “Internet Histories.” [less ▲]

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See detailCities seen through a relational lens
Hesse, Markus UL; Wong, Catherine UL

in Geographische Zeitschrift (2020), 108(2), 74-98

This paper applies a relational approach to global urbanization with respect to the economic flows and relationships that help local places to position themselves globally. The paper ties in with the ... [more ▼]

This paper applies a relational approach to global urbanization with respect to the economic flows and relationships that help local places to position themselves globally. The paper ties in with the increasing functional and economic integration of urban areas – an integration that is not primarily related to economic or population size but an outcome of specialization and a politics of niche sovereignty. Empirically the paper draws upon case studies of three different places: Geneva (Switzerland), Luxembourg City (Luxembourg) and the citystate of Singapore. We reconstruct the different ways in which these three became part of global networks, and how the crafting of political frameworks based on niche making has fostered their rise in global significance. [less ▲]

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See detailDas Zinsregister der Luxemburger Deutschordenskommende von 1457-1458. Edition und Kommentar
Pauly, Michel UL

in Hémecht: Zeitschrift für Luxemburger Geschichte (2020), 72(2), 174-194

The article presents a twelve-page register dating back to 1457-58, which lists the annual rent incomes of the Teutonic Order based at the St. Elisabeth House in Ulrichgasse in the city of Luxembourg. The ... [more ▼]

The article presents a twelve-page register dating back to 1457-58, which lists the annual rent incomes of the Teutonic Order based at the St. Elisabeth House in Ulrichgasse in the city of Luxembourg. The article describes this rare source, asks about the possible circumstances of its origins and elaborates some prosopographical, topographical and economic conclusions that may be drawn from it. In the last part, it offers a critical edition of the document. [less ▲]

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See detailCan Visual Design Provide Legal Transparency? The Challenges for Successful Implementation of Icons for Data Protection
Rossi, Arianna UL; Palmirani, Monica

in Design Issues (2020), 36(3), 82-96

Design is a key player in the future of data privacy and data protection. The General Data Protection Regulation (GDPR) established by the European Union aims to rebalance the information asymmetry ... [more ▼]

Design is a key player in the future of data privacy and data protection. The General Data Protection Regulation (GDPR) established by the European Union aims to rebalance the information asymmetry between the organizations that process personal data and the individuals to which that data refers. Machine-readable, standardized icons that present a “meaningful overview of the intended processing” are suggested by the law as a tool to enhance the transparency of information addressed to data subjects. However, no specific guidelines have been provided, and studies on privacy iconography are very few. This article describes research conducted on the creation and evaluation of icons representing data protection concepts. First, we introduce the methodology used to design the Data Protection Icon Set (DaPIS): participatory design methods combined with legal ontologies and machine-readable representations. Second, we discuss some of the challenges that have been faced in the development and evaluation of DaPIS and similar icon sets. Third, we provide some tentative responses and indicate a way forward for evaluation of the effectiveness of privacy icons and their widespread adoption. [less ▲]

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See detailPROMISE: high-level mission specification for multiple robots
García, Sergio; Pelliccione, Patrizio; Menghi, Claudio UL et al

in International Conference on Software Engineering: Companion Proceedings (2020)

Service robots, a type of robots that perform useful tasks for humans, are foreseen to be broadly used in the near future in both social and industrial scenarios. Those robots will be required to operate ... [more ▼]

Service robots, a type of robots that perform useful tasks for humans, are foreseen to be broadly used in the near future in both social and industrial scenarios. Those robots will be required to operate in dynamic environments, collaborating among them or with users. Specifying the list of requested tasks to be achieved by a robotic team is far from being trivial. Therefore, mission specification languages and tools need to be expressive enough to allow the specification of complex missions (e.g., detailing recovery actions), while being reachable by domain experts who might not be knowledgeable of programming languages. To support domain experts, we developed PROMISE, a Domain-Specific Language that allows mission specification for multiple robots in a user-friendly, yet rigorous manner. PROMISE is built as an Eclipse plugin that provides a textual and a graphical interface for mission specification. Our tool is in turn integrated into a software framework, which provides functionalities as: (1) automatic generation from specification, (2) sending of missions to the robotic team; and (3) interpretation and management of missions during execution time. PROMISE and its framework implementation have been validated through simulation and real-world experiments with four different robotic models. [less ▲]

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See detailCasimir force between Weyl semimetals in a chiral medium
Farias, Maria Belen UL; Zyuzin, Alexander A.; Schmidt, Thomas UL

in Physical Review. B (2020), 101

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See detailStatelessness the proof of a negative
Sommarribas, Adolfo UL

in Journaal Vreemdelingenrecht (2020), 19(2/2020), 30-37

This article provides an overview of what the Member States of the European Union are doing in order to tackle statelessness in the European Union through the European Migration Network Platform on ... [more ▼]

This article provides an overview of what the Member States of the European Union are doing in order to tackle statelessness in the European Union through the European Migration Network Platform on Statelessness. It also provides an overview of the state of play of statelessness in the European Union based on the EMN Inform entitled ‘Statelessness in the EU’ putting emphasis on the burden and standard of proof. [less ▲]

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See detailAutomated Fault Tolerance Augmentation in Model-Driven Engineering for CPS
Hu, Tingting UL; Cibrario Bertolotti, Ivan; Navet, Nicolas UL et al

in Computer Standards & Interfaces (2020), 70

Cyber-Physical Systems are usually subject to dependability requirements such as safety and reliability constraints. Over the last 50 years, a body of efficient fault-tolerance mechanisms has been devised ... [more ▼]

Cyber-Physical Systems are usually subject to dependability requirements such as safety and reliability constraints. Over the last 50 years, a body of efficient fault-tolerance mechanisms has been devised to handle faults occurring at run-time. However, properly implementing those mechanisms is a time-consuming task that requires a great deal of know-how. In this paper, we propose a general framework which allows system designers to decouple functional and non-functional concerns, and express non- functional properties at design time using domain-specific languages. In the spirit of generative programming, functional models are then automatically “augmented” with dependability mechanisms. Importantly, the real-time behavior of the initial models in terms of sampling times and meeting deadlines is preserved. The practicality of the approach is demonstrated with the automated implementation of one prominent software fault-tolerance pattern, namely N-Version Programming, in the CPAL model-driven engineering workflow. [less ▲]

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See detailExploring ‘vibrant matter’ in animation making
Budach, Gabriele UL; Sharoyan, Gohar UL

in Language and Intercultural Communication (2020), 20(5), 464-481

The text examines how human, objects and digital technology interacted in the creation of a short animated story, and how human identity became entangled in this process. We explore animation making as an ... [more ▼]

The text examines how human, objects and digital technology interacted in the creation of a short animated story, and how human identity became entangled in this process. We explore animation making as an assemblage in which all parts, human and non-human, play an agentive role, in shaping the story, the story making, and the story makers, mutually transforming each other. We posit that this engagement, by putting a strong emphasis on exploring the materiality of objects, produces a deand reterritorializing effect. It favors exploring new relationships and identity positions, by breaking away, temporarily, from human-made, hierarchical systems of relationships, built on comparison, copying and competition, and by inviting experimentation and discovery of the ‘not yet known’ in a hierarchy flat, immersive, horizontally flowing process. ‘Animating objects’ decenters from the conventional meaning of objects, by broadening the ‘linguistic sign’ and the purpose and functionality of objects in daily life. It engages humans in forming empathetic relationships with objects, by humanizing and inter-acting with them, as if experimenting with an alter ego, or a new self. ‘Animating objects’ therefore has the potential to sensitize for and build empathetic capacity, not only in relation to the self-animated object, but also in relation to humans sharing a similar experience, wherein we see interesting potential for education in contexts of diversity, intercultural communication and beyond. We investigate the personal experience of the co-author, Gohar, as an identity journey and as a transformative process that emerged from the encounter between her and the carrots, her selected objects for story making. We draw on ethnographic, observational data, video-recordings, retrospective recorded and transcribed interviews, and reflective writing, which we analyse by making connections to theories of new materialism. [less ▲]

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See detailBook Review: Counter-Terrorism, Constitutionalism and Miscarriages of Justice: A Festschrift for Professor Clive Walker
Robinson, Gavin UL

in New Journal of European Criminal Law (2020), 11(2), 258-261

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See detailGlobal technologies, glocal approach: a false paradox
Schafer, Valerie UL

in Esboços: histórias em contextos globais (2020), 27(45), 286-305

This article seeks to identify the factors that have led researchers to root their historical approach in a national or regional context, rather than a global one. This may seem paradoxical when the ... [more ▼]

This article seeks to identify the factors that have led researchers to root their historical approach in a national or regional context, rather than a global one. This may seem paradoxical when the Internet is thought to be global, and digital content and cultures at least partially cross-borders. These approaches are determined by reactions to a history of the Internet that has been far too focused on the United States from the outset, by a desire to consider this history in a given context, and by the historical sources. However, the use of national and regional approaches does not preclude the stimulating comparative or transnational perspectives that may renew this history in terms of infrastructure, missing narratives and user participation, as well as technical and human networks. We even suggest that studying the history of the places, people and communities that remain outside networks (whether by choice or by necessity) could tell us a lot about the global and asymmetric reality of the Internet. [less ▲]

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See detailThe Temporary Reintroduction of Border Controls Inside theSchengen Area: Towards a Spatial Perspective
Evrard, Estelle UL; Nienaber, Birte UL; Sommarribas, Adolfo UL

in Journal of Borderlands Studies (2020), 35(3), 369-383

Following the terrorist attacks in Paris (November 2015) and Brussels(March 2016), several EU Member States have decided to re-establish border controls or to build walls inside the Schengen Area ... [more ▼]

Following the terrorist attacks in Paris (November 2015) and Brussels(March 2016), several EU Member States have decided to re-establish border controls or to build walls inside the Schengen Area. Although these decisions are temporary and legally framed by the Schengen code, their extent disrupts the free movement within the Schengen Area, in particular in border areas. While lawyers and economists have analyzed the impacts of this situation, the spatial perspective has remained rather neglected.This exploratory contribution aims to address this gap in the literature by outlining the spatial significance of reintroduced controls for border areas inside the Schengen Area. This contribution firstly undertakes a literature review of the different conceptual tools at hand. These are then compared with a set of exploratory empirical materials. The article focuses more precisely on the Greater Region where France and Germany have reintroduced border controls, thus disrupting in particular daily cross-border flows with Luxembourg and Belgium. The analysis demonstrates that the border acts as a filter, disrupting cross-border flows and cooperation. Also, it sheds some light on the important role played by the ideational perception of the border for practitioners and decision-makers. This contribution concludes by suggesting several paths for a future research agenda. [less ▲]

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See detailTokenization of Sukuk: Ethereum Case Study
Khan, Nida UL; Kchouri, Bilal UL; Yatoo, Nissar Ahmad et al

in Global Finance Journal (2020)

Sukuk is a financial instrument that provides returns similar to conventional bonds. It has served to cater to the capital requirements of big corporations and governments, while circumventing interest to ... [more ▼]

Sukuk is a financial instrument that provides returns similar to conventional bonds. It has served to cater to the capital requirements of big corporations and governments, while circumventing interest to adhere to the Shariah law. Sukuk can be touted as Shariah-compliant bonds that rank amongst the most successful and the fastest growing financial instrument in the Islamic economy. The sukuk research area is marked by a dearth of quantitative literature, compared to qualitative academic work. This paper seeks to fill this existing gap, and introduces a novel, exploratory analysis of sukuk tokenization based on a case study. The funding needs of small and medium enterprises remains largely unmet through sukuk on account of the high costs involved, among other reasons. As we show in this paper, blockchains can aid to lower the cost incurred through the tokenization of sukuk. We highlight some of the key challenges involved in the issuance of sukuk and discuss their resolution using blockchain. We also provide a taxonomy of blockchain applications in finance, with a particular focus on Islamic finance. Our paper reviews different blockchain architectures to assess their viability for tokenization. We conduct a novel case study on sukuk tokenization by implementing a basic smart contract for Sukuk al-Murabaha on Ethereum. The paper concludes by a conceptual analysis of feasibility concerns, based on a comparison of the conducted cost-benefit analysis of conventional sukuk issuance with tokenization. [less ▲]

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See detailIoV-based Deployment and Scheduling of Charging Infrastructure in Intelligent Transportation Systems
Ejaz, Waleed; Naeem, Mohammed; Sharma, Shree Krishna UL et al

in IEEE Sensors Journal (2020)

Internet of vehicles (IoV) is an emerging paradigm to exchange and analyze information collected from sensors using wireless technologies between vehicles and people, vehicles and infrastructure, and ... [more ▼]

Internet of vehicles (IoV) is an emerging paradigm to exchange and analyze information collected from sensors using wireless technologies between vehicles and people, vehicles and infrastructure, and vehicles-to-vehicles. With the recent increase in the number of electric vehicles (EVs), the seamless integration of IoV in EVs and charging infrastructure can offer environmentally sustainable and budget-friendly transportation. In this paper, we propose an IoV-based framework that consists of deployment and scheduling of a mobile charging infrastructure. For the deployment, we formulate an optimization problem to minimize the total cost of mobile charging infrastructure placement while considering constraints on the number of EVs that can be charged simultaneously. The formulated problem is mixedinteger programming and solved by using the branch and bound algorithm. We then propose an IoV-based scheduling scheme for EVs charging to minimize travel distance and charging costs while satisfying the constraints of charging time requirement of EVs and resources of a charging station.We consider passive road sensors and traffic sensors in the proposed IoV-based scheduling scheme to enable EV users for finding a charging station that can fulfill their requirements, as well as to enable service providers to know about the demand in the area. Simulation results illustrate the significant impact of the optimal deployment of charging infrastructure and scheduling optimization on the efficiency of EVs charging. [less ▲]

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See detailA Note on Stein’s Overreaction Puzzle
Lin, Yuehao; Lehnert, Thorsten UL

in Decisions in Economics and Finance (2020), 43(1), 269-276

Recently, Christoffersen et al. (2013) argue that the overreaction puzzle of Stein (1989) can be explained by a variance-dependent pricing kernel. In this note, we challenge this view. Our theoretical ... [more ▼]

Recently, Christoffersen et al. (2013) argue that the overreaction puzzle of Stein (1989) can be explained by a variance-dependent pricing kernel. In this note, we challenge this view. Our theoretical results are in line with their argument that the variance under risk-neutral measure is more persistent than the variance under physical measure due to a negative variance risk premium. But our results do not support their argument that the more persistent variance is able to qualitatively explain Stein’s findings. We show theoretically that the persistence of the volatility cannot amplify the movements of long-term variance to short-term fluctuations in variance, and, therefore, conclude that Stein’s overreaction puzzle is still unsolved. [less ▲]

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See detailAutomatic Generation of Acceptance Test Cases from Use Case Specifications: an NLP-based Approach
Wang, Chunhui UL; Pastore, Fabrizio UL; Göknil, Arda UL et al

in IEEE Transactions on Software Engineering (2020)

Acceptance testing is a validation activity performed to ensure the conformance of software systems with respect to their functional requirements. In safety critical systems, it plays a crucial role since ... [more ▼]

Acceptance testing is a validation activity performed to ensure the conformance of software systems with respect to their functional requirements. In safety critical systems, it plays a crucial role since it is enforced by software standards, which mandate that each requirement be validated by such testing in a clearly traceable manner. Test engineers need to identify all the representative test execution scenarios from requirements, determine the runtime conditions that trigger these scenarios, and finally provide the input data that satisfy these conditions. Given that requirements specifications are typically large and often provided in natural language (e.g., use case specifications), the generation of acceptance test cases tends to be expensive and error-prone. In this paper, we present Use Case Modeling for System-level, Acceptance Tests Generation (UMTG), an approach that supports the generation of executable, system-level, acceptance test cases from requirements specifications in natural language, with the goal of reducing the manual effort required to generate test cases and ensuring requirements coverage. More specifically, UMTG automates the generation of acceptance test cases based on use case specifications and a domain model for the system under test, which are commonly produced in many development environments. Unlike existing approaches, it does not impose strong restrictions on the expressiveness of use case specifications. We rely on recent advances in natural language processing to automatically identify test scenarios and to generate formal constraints that capture conditions triggering the execution of the scenarios, thus enabling the generation of test data. In two industrial case studies, UMTG automatically and correctly translated 95% of the use case specification steps into formal constraints required for test data generation; furthermore, it generated test cases that exercise not only all the test scenarios manually implemented by experts, but also some critical scenarios not previously considered. [less ▲]

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See detailTkT: Automatic Inference of Timed and Extended Pushdown Automata
Pastore, Fabrizio UL; Micucci, Daniela; Guzman, Michell et al

in IEEE Transactions on Software Engineering (2020)

To mitigate the cost of manually producing and maintaining models capturing software specifications, specification mining techniques can be exploited to automatically derive up-to-date models that ... [more ▼]

To mitigate the cost of manually producing and maintaining models capturing software specifications, specification mining techniques can be exploited to automatically derive up-to-date models that faithfully represent the behavior of software systems. So far, specification mining solutions focused on extracting information about the functional behavior of the system, especially in the form of models that represent the ordering of the operations. Well-known examples are finite state models capturing the usage protocol of software interfaces and temporal rules specifying relations among system events. Although the functional behavior of a software system is a primary aspect of concern, there are several other non-functional characteristics that must be typically addressed jointly with the functional behavior of a software system. Efficiency is one of the most relevant characteristics. In fact, an application delivering the right functionalities inefficiently has a big chance to not satisfy the expectation of its users. Interestingly, the timing behavior is strongly dependent on the functional behavior of a software system. For instance, the timing of an operation depends on the functional complexity and size of the computation that is performed. Consequently, models that combine the functional and timing behaviors, as well as their dependencies, are extremely important to precisely reason on the behavior of software systems. In this paper, we address the challenge of generating models that capture both the functional and timing behavior of a software system from execution traces. The result is the Timed k-Tail (TkT) specification mining technique, which can mine finite state models that capture such an interplay: the functional behavior is represented by the possible order of the events accepted by the transitions, while the timing behavior is represented through clocks and clock constraints of different nature associated with transitions. Our empirical evaluation with several libraries and applications show that TkT can generate accurate models, capable of supporting the identification of timing anomalies due to overloaded environment and performance faults. Furthermore, our study shows that TkT outperforms state-of-the-art techniques in terms of scalability and accuracy of the mined models. [less ▲]

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See detailScattering theory without injectivity radius assumptions, and spectral stability for the Ricci flow
Güneysu, Batu; Thalmaier, Anton UL

in Annales de l'Institut Fourier (2020), 70(1), 437-456

We prove a new integral criterion for the existence and completeness of the wave operators W_{\pm}(-\Delta_h,-\Delta_g, I_{g,h}) corresponding to the (unique self-adjoint realizations of) the Laplace ... [more ▼]

We prove a new integral criterion for the existence and completeness of the wave operators W_{\pm}(-\Delta_h,-\Delta_g, I_{g,h}) corresponding to the (unique self-adjoint realizations of) the Laplace-Beltrami operators -\Delta_j, j=g,h, that are induced by two quasi-isometric complete Riemannian metrics g and h on an open manifold M. In particular, this result provides a criterion for the absolutely continuous spectra of -\Delta_g and -\Delta_h to coincide. Our proof relies on estimates that are obtained using a probabilistic Bismut type formula for the gradient of a heat semigroup. Unlike all previous results, our integral criterion only requires some lower control on the Ricci curvatures and some upper control on the heat kernels, but no control at all on the injectivity radii. As a consequence, we obtain a stability result for the absolutely continuous spectrum under a Ricci flow. [less ▲]

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See detailReply: NAD(P)HX dehydratase protein-truncating mutations are associated with neurodevelopmental disorder exacerbated by acute illness
Van Bergen, Nicole J.; Linster, Carole UL; Christodoulou, John

in Brain: a Journal of Neurology (2020), 143(7), 55

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See detailMindfulness in everyday life: Between- and within-person relationships to motivational conflicts
Senker, Kerstin; Fries, Stefan; Grund, Axel UL

in Current Psychology (2020)

Mindfulness has shown beneficial relationships with well-being and self-regulation. We aim to improve the understanding of the effects of between- and within-person differences in mindfulness when dealing ... [more ▼]

Mindfulness has shown beneficial relationships with well-being and self-regulation. We aim to improve the understanding of the effects of between- and within-person differences in mindfulness when dealing with situations of motivational conflict. For this purpose, we conducted an experience sampling study with 56 university students who replied to a total of N = 1889 short questionnaires, which they received via their smartphones over a period of eight consecutive days. In addition to a state mindfulness questionnaire with the facets presence and non-judgment (focusing attention on the experience of the current action and a momentary non-judgmental stance towards these, respectively), the participants received questions about their current affective well-being and perceived intensity of want or should conflict experiences. Multi-level analyses revealed that want conflicts were predicted by both state mindfulness facets, even after momentary affect was controlled. In addition, to be non-judgmental (as a trait), and having momentary presence (as a state), related to lower intensity of should conflicts. The results suggest that being mindful might be a particularly beneficial way of dealing with daily motivational conflicts, which is an essential and frequent task of self-regulation. [less ▲]

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See detailIn context: emotional intent and temporal immediacy of contextual descriptions modulate affective ERP components to facial expressions
Rischer, Katharina Miriam UL; Savallampi, Mattias; Akwaththage, Anushka et al

in Social Cognitive and Affective Neuroscience (2020)

In this study, we explored how contextual information about threat dynamics affected the electrophysiological correlates of face perception. Forty-six healthy native Swedish speakers read verbal ... [more ▼]

In this study, we explored how contextual information about threat dynamics affected the electrophysiological correlates of face perception. Forty-six healthy native Swedish speakers read verbal descriptions signaling an immediate vs delayed intent to escalate or deescalate an interpersonal conflict. Each verbal description was followed by a face with an angry or neutral expression, for which participants rated valence and arousal. Affective ratings confirmed that the emotional intent expressed in the descriptions modulated emotional reactivity to the facial stimuli in the expected direction. The electrophysiological data showed that compared to neutral faces, angry faces resulted in enhanced early and late event-related potentials (VPP, P300 and LPP). Additionally, emotional intent and temporal immediacy modulated the VPP and P300 similarly across angry and neutral faces, suggesting that they influence early face perception independently of facial affect. By contrast, the LPP amplitude to faces revealed an interaction between facial expression and emotional intent. Deescalating descriptions eliminated the LPP differences between angry and neutral faces. Together, our results suggest that information about a person’s intentions modulates the processing of facial expressions. [less ▲]

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See detailIntersectionality and Adolescent Mental Well-being: A Cross-Nationally Comparative Analysis of the Interplay Between Immigration Background, Socioeconomic Status and Gender
Kern, Matthias Robert UL; Duinhof, Elisa L.; Walsh, Sophie D. et al

in Journal of Adolescent Health (2020), 66(6), 12-20

Purpose: Intersectionality theory highlights the importance of the interplay of multiple social group memberships in shaping individual mental well-being. This article investigates elements of adolescent ... [more ▼]

Purpose: Intersectionality theory highlights the importance of the interplay of multiple social group memberships in shaping individual mental well-being. This article investigates elements of adolescent mental well-being (life dissatisfaction and psychosomatic complaints) from an intersectional perspective. It tests mental well-being consequences of membership in combinations of multiple social groups and examines to what extent such intersectional effects depend on the national context (immigration and integration policies, national-level income, and gender equality). Methods: Using Multilevel Analysis of Individual Heterogeneity and Discriminatory Accuracy, we assessed the role of the national context in shaping the interplay between immigration background, socioeconomic status, and gender, using data from 33 countries from the 2017/2018 Health Behaviour in School-aged Children survey. Results: We found no uniform intersectionality effects across all countries. However, when allowing the interplay to vary by national context, results did point toward some intersectional effects. Some aggravated negative effects were found for members of multiple disadvantaged social groups in countries with low levels of income equality and restrictive migration policies, whereas enhanced positive effects were found for members of multiple advantaged groups in these countries. Similarly, mitigated negative effects of membership in multiple disadvantaged groups were shown in countries with higher levels of income equality and more inclusive migration policies, whereas mitigated positive effects were found for multiply advantaged individuals. Although for national-level gender equality results pointed in a similar direction, girls’ scores were counterintuitive. High national-level gender equality disproportionately benefitted groups of disadvantaged boys, whereas advantaged girls were doing worse than expected, and reversed effects were found for countries with low gender equality. Conclusions: To fully understand social inequalities in adolescent mental well-being, the interplay between individual-level and national-level indicators must be explored. [less ▲]

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See detailAgent-based, hybrid control architecture for optimized and flexible production scheduling and control in remanufacturing
Groß, Sebastian UL; Gerke, Wolfgang; Plapper, Peter UL

in Journal of Remanufacturing (2020), (2020),

Introduction: Motivated by high ecological and economical potentials and driven by new laws, remanufacturing is receiving increasing attention as a process that puts used products into “as good as new or ... [more ▼]

Introduction: Motivated by high ecological and economical potentials and driven by new laws, remanufacturing is receiving increasing attention as a process that puts used products into “as good as new or better” condition. Within this process, there are many challenges, which are unseen in manufacturing, such as the uncertainties resulting from unknown conditions of the used products. This places special demands on the control of the remanufacturing system (RS). Methodology: To handle these uncertainties an agent-based hybrid control architecture comprising centralized and decentralized components is presented. In the former, the scheduling takes place including the consideration of the use of automated guided vehicles (AGV) to realize flexible material handling within the RS. The scheduling of machines and AGVs is thereby considered simultaneously and not separately, as it is the case in currently available control systems. For the optimization of the simultaneous scheduling Constraint Programming (CP) is used. In the decentralized component, all participants within the RS will be networked as a cyber-physical system and controlled by respective agents. These agents can communicate with each other in order to find solutions. The architecture is implemented as a multi-agent system. Results: Simulation results, using benchmark instances, show that simultaneous scheduling results in a 19.7% reduction of the makespan. Furthermore, the CP-based approach delivers the best results, compared to other approaches for simultaneous scheduling, which are also achieved in a significantly shorter computing time. [less ▲]

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See detailAmyloid Evolution: Antiparallel Replaced by Parallel
Hakami Zanjani, Ali Asghar UL; Reynolds, Nicholas; Zhang, Afang et al

in Biophysical Journal (2020), 118

Several atomic structures have now been found for micrometer-scale amyloid fibrils or elongated microcrystals using a range of methods, including NMR, electron microscopy, and X-ray crystallography, with ... [more ▼]

Several atomic structures have now been found for micrometer-scale amyloid fibrils or elongated microcrystals using a range of methods, including NMR, electron microscopy, and X-ray crystallography, with parallel beta-sheet appearing as the most common secondary structure. The etiology of amyloid disease, however, indicates nanometer-scale assemblies of only tens of peptides as significant agents of cytotoxicity and contagion. By combining solution X-ray with molecular dynamics, weshow that antiparallel structure dominates at the first stages of aggregation for a specific set of peptides, being replaced by parallel at large length scales only. This divergence in structure between small and large amyloid aggregates should inform future design of molecular therapeutics against nucleation or intercellular transmission of amyloid. Calculations and an overview from the literature argue that antiparallel order should be the first appearance of structure in many or most amyloid aggregation processes, regardless of the endpoint. Exceptions to this finding should exist, depending inevitably on the sequence and on solution conditions. [less ▲]

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See detailMeasurement invariance of the Positive Gains Scale in families of children with and without disabilities
Jess, Mikeda; Bailey, Tom; Pit-Ten Cate, Ineke UL et al

in Research in Developmental Disabilities (2020), 103

Background Despite the high frequency of case-control studies in the developmental disability literature, there is a paucity of research establishing the measurement equivalence of instruments used, and ... [more ▼]

Background Despite the high frequency of case-control studies in the developmental disability literature, there is a paucity of research establishing the measurement equivalence of instruments used, and particularly those relating to positive perceptions and experiences in family disability research. Aims The present study sought to establish measurement invariance for the Positive Gains Scale (PGS) across 1219 mothers of children with developmental disabilities, 234 mothers of children with spina bifida/hydrocephalus, and 157 mothers of children without disabilities. Methods and Procedures A three-step test for measurement invariance across the three groups was conducted using Multigroup Confirmatory Factor Analysis. Outcomes and Results Loadings between the three groups were invariant, suggesting the criteria to assume metric invariance was met. However, the assumption of scalar invariance was not met, suggesting that item intercepts differed between the three groups. Conclusions and Implications Our findings suggest that the PGS cannot be meaningfully used to compare outcomes between mothers of children with developmental disabilities and other mothers. These findings may have wider implications for research utilising well-being measures to make comparisons with carers of children with developmental disabilities. [less ▲]

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See detailGuidelines for Operationalizing Policy Coherence for Development (PCD) as a Methodology for the Design and Implementation of Sustainable Development Strategies
Koff, Harlan UL; Challenger, Antony; Portillo, Israel

in Sustainability (2020), 12(4055), 1-23

Policy Coherence for Development (PCD) is considered a pillar of the 2030 Sustainable Development Agenda. It aims to promote whole of government approaches to sustainable development. Despite its ... [more ▼]

Policy Coherence for Development (PCD) is considered a pillar of the 2030 Sustainable Development Agenda. It aims to promote whole of government approaches to sustainable development. Despite its prominence in development cooperation discussions, many national development professionals or stakeholders have not heard of PCD, indicating that its effectiveness is significantly limited. This article contends that the impact of PCD has not been maximized because it has been presented as a political objective or a policy tool by multilateral organizations and their member states. Instead, the article argues that PCD should be implemented as a methodology that can be adopted by domestic government and non-governmental actors alike, in order to understand trade-offs and co-benefits within and between policy sectors, thus promoting a participative approach. I-GAMMA is a research project in Mexico that examines data-driven public policy in order to promote PCD. It is based on in-depth reviews of policy documents and interviews with development actors. It is committed to open data, evidence-based policymaking, and collaborative dialogue between academics, government officials, and representatives of civil society organizations in sustainable development discussions. In the results section of this article, the project proposes participative PCD as a methodology for policy analysis through which a plurality of actors can identify mechanisms that either reinforce or undermine sustainable development strategies. This section then applies the methodology to the governance of protected natural areas in Mexico. The discussion section and the conclusions highlight the relevance of this approach for participative policymaking in sustainable development. [less ▲]

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See detailGastric interoception and gastric myoelectrical activity in bulimia nervosa and binge eating disorder
van Dyck, Zoé UL; Schulz, André UL; Blechert, Jens et al

in International Journal of Eating Disorders (2020)

Objective: Identifying factors that control food intake is crucial to the understanding and treatment of eating disorders characterized by binge eating. In healthy individuals, stomach distension plays an ... [more ▼]

Objective: Identifying factors that control food intake is crucial to the understanding and treatment of eating disorders characterized by binge eating. In healthy individuals, stomach distension plays an important role in the development of satiation, but gastric sensations might be overridden in binge eating. The present study investigated the perception of gastric signals (i.e., gastric interoception) and gastric motility in patients experiencing binge eating episodes, i.e. bulimia nervosa (BN) and binge-eating disorder (BED). Method: Twenty-nine patients with BN or BED (ED group) and 32 age-, sex-, and BMI-matched healthy controls (HC group) participated in the study. The onset of satiation and stomach fullness were assessed using a novel 2-step water load test (WLT-II). Gastric myoelectrical activity (GMA) was measured by electrogastrography (EGG) before and after ingestion of non-caloric water. Results: Individuals in the ED group drank significantly more water until reporting satiation during the WLT-II. The percentage of normal gastric myoelectrical power was significantly smaller in the ED group compared to HC, and negatively related to the number of objective binge-eating episodes per week in bulimic patients. Power in the bradygastria range was greater in ED than in HC subjects. Discussion: Patients with EDs have a delayed response to satiation compared to HC participants, together with abnormal GMA. Repeated binge eating episodes may induce disturbances to gastric motor function. [less ▲]

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See detailMISCAST: MIssense variant to protein StruCture Analysis web SuiTe
Iqbal, Sumaiya; Hoksza, David UL; Pérez-Palma, Eduardo et al

in Nucleic Acids Research (2020)

Human genome sequencing efforts have greatly expanded, and a plethora of missense variants identified both in patients and in the general population is now publicly accessible. Interpretation of the ... [more ▼]

Human genome sequencing efforts have greatly expanded, and a plethora of missense variants identified both in patients and in the general population is now publicly accessible. Interpretation of the molecular-level effect of missense variants, however, remains challenging and requires a particular investigation of amino acid substitutions in the context of protein structure and function. Answers to questions like ‘Is a variant perturbing a site involved in key macromolecular interactions and/or cellular signaling?’, or ‘Is a variant changing an amino acid located at the protein core or part of a cluster of known pathogenic mutations in 3D?’ are crucial. Motivated by these needs, we developed MISCAST (missense variant to protein structure analysis web suite; http://miscast.broadinstitute.org/). MISCAST is an interactive and user-friendly web server to visualize and analyze missense variants in protein sequence and structure space. Additionally, a comprehensive set of protein structural and functional features have been aggregated in MISCAST from multiple databases, and displayed on structures alongside the variants to provide users with the biological context of the variant location in an integrated platform. We further made the annotated data and protein structures readily downloadable from MISCAST to foster advanced offline analysis of missense variants by a wide biological community. [less ▲]

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See detailEuropeanizing Universities: Expanding and Consolidating Networks of the Erasmus Mundus Joint Master Degree Programme (2004–2017)
Marques, Marcelo; Zapp, Mike UL; Powell, Justin J W UL

in Higher Education Policy (2020)

The Europeanization of higher education has gained considerable scope and momentum over the past quarter century. Whereas the coordinative Bologna process, with soft governance mechanisms, have ... [more ▼]

The Europeanization of higher education has gained considerable scope and momentum over the past quarter century. Whereas the coordinative Bologna process, with soft governance mechanisms, have facilitated standardization across countries, European Commission funding programs targeted universities more directly. The Erasmus Mundus Joint Degree Programme, as an incentive-based program, epitomizes the dynamics of such European funding management. Notably, it has established expanding university networks across Europe and unique new tertiary degrees that facilitate student mobility. Applying social network analysis to 561 participating universities through several program cycles, we longitudinally examine three key patterns in the program’s development: the expansion of the programme, the consolidation of networks, and the participation of and coordination by central universities in these processes. Program participation increased considerably across cycles, even as established networks were consolidated, largely through re- accreditation of established programs. Moreover, we identify those universities that assume a central position in the inter-organizational structure of this international program. These universities actively facilitate the evolving Europeanization of higher education by strengthening inter-university networks via a signature EU program. [less ▲]

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See detailHybrid User Pairing for Spectral and Energy Efficiencies in Multiuser MISO-NOMA Networks with SWIPT
Nguyen, Toan-Van; Nguyen, van Dinh UL; Costa, Daniel Benevides Da et al

in IEEE Transactions on Communications (2020), 68(8), 4874-4890

In this paper, we propose a novel hybrid user pairing (HUP) scheme in multiuser multiple-input single-output nonorthogonal multiple access networks with simultaneous wireless information and power ... [more ▼]

In this paper, we propose a novel hybrid user pairing (HUP) scheme in multiuser multiple-input single-output nonorthogonal multiple access networks with simultaneous wireless information and power transfer. In this system, two information users with distinct channel conditions are optimally paired while energy users perform energy harvesting (EH) under non-linearity of the EH circuits. We consider the problem of jointly optimizing user pairing and power allocation to maximize the overall spectral efficiency (SE) and energy efficiency (EE) subject to userspecific quality-of-service and harvested power requirements. A new paradigm for the EE-EH trade-off is then proposed to achieve a good balance of network power consumption. Such design problems are formulated as the maximization of nonconcave functions subject to the class of mixed-integer non-convex constraints, which are very challenging to solve optimally. To address these challenges, we first relax binary pairing variables to be continuous and transform the design problems into equivalent non-convex ones, but with more tractable forms. We then develop low-complexity iterative algorithms to improve the objectives and converge to a local optimum by means of the inner approximation framework. Simulation results show the convergence of proposed algorithms and the SE and EE improvements of the proposed HUP scheme over state-of-the-art designs. In addition, the effects of key parameters such as the number of antennas and dynamic power at the BS, target data rates, and energy threshold, on the system performance are evaluated to show the effectiveness of the proposed schemes in balancing resource utilization. [less ▲]

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See detailFear and Stock Price Bubbles
Lehnert, Thorsten UL

in PLoS ONE (2020), 15 (5)(e0233024), 1-11

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See detailDeep Channel Learning For Large Intelligent Surfaces Aided mm-Wave Massive MIMO Systems
Elbir, Ahmet M.; Papazafeiropoulos, Anastasios; Kourtessis, Pandelis et al

in IEEE Wireless Communications Letters (2020), 9(Sept. 2020), 1447-1451

This letter presents the first work introducing a deep learning (DL) framework for channel estimation in large intelligent surface (LIS) assisted massive MIMO (multiple-input multiple-output) systems. A ... [more ▼]

This letter presents the first work introducing a deep learning (DL) framework for channel estimation in large intelligent surface (LIS) assisted massive MIMO (multiple-input multiple-output) systems. A twin convolutional neural network (CNN) architecture is designed and it is fed with the received pilot signals to estimate both direct and cascaded channels. In a multi-user scenario, each user has access to the CNN to estimate its own channel. The performance of the proposed DL approach is evaluated and compared with state-of-the-art DL-based techniques and its superior performance is demonstrated. [less ▲]

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See detailTransforming Unitary States into Federations: Path-Dependent Construction of Political Identities in Belgium and Lebanon
Poirier, Philippe UL; Farhat, Nadim UL; Bourbeau, Philippe et al

in Publius: the Journal of Federalism (2020), pjaa007

The theory of congruence in comparative federalism holds that institutional design will, eventually, reflect societal divisions by transferring central powers to new, autonomous entities. While this model ... [more ▼]

The theory of congruence in comparative federalism holds that institutional design will, eventually, reflect societal divisions by transferring central powers to new, autonomous entities. While this model helps to understand why many divided societies adopt federalism, it cannot explain why only certain unitary states transform into federal ones while others do not. We use a historical institutionalism approach to identify the critical junctures in the trajectory of two prominent plural polities, Belgium and Lebanon. We suggest that the politicization of identities during initial stages of state-building plays a major role in the transformation of a unitary state into a federation—which occurs in the former but not in the latter of our cases. The current contrast in both consociational democracies is explained here as a legacy of the late nineteenth century, which set in motion decisive logics of public governance that direct institutional dynamics until today. [less ▲]

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See detailEmerging Techniques and Applications for 5G Networks and Beyond
Nguyen, van Dinh UL; Duong, Trung Q; Vien, Quoc-Tuan

in Mobile Networks and Applications (2020)

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See detailTowards the routine use of in silico screenings for drug discovery using metabolic modelling
Bintener, Tamara Jean Rita UL; Pires Pacheco, Maria Irene UL; Sauter, Thomas UL

in Biochemical Society Transactions (2020)

Currently, the development of new effective drugs for cancer therapy is not only hindered by development costs, drug efficacy, and drug safety but also by the rapid occurrence of drug resistance in cancer ... [more ▼]

Currently, the development of new effective drugs for cancer therapy is not only hindered by development costs, drug efficacy, and drug safety but also by the rapid occurrence of drug resistance in cancer. Hence, new tools are needed to study the underlying mechanisms in cancer. Here, we discuss the current use of metabolic modelling approaches to identify cancer-specific metabolism and find possible new drug targets and drugs for repurposing. Furthermore, we list valuable resources that are needed for the reconstruction of cancer-specific models by integrating various available datasets with genome-scale metabolic reconstructions using model-building algorithms. We also discuss how new drug targets can be determined by using gene essentiality analysis, an in silico method to predict essential genes in a given condition such as cancer and how synthetic lethality studies could greatly benefit cancer patients by suggesting drug combinations with reduced side effects. [less ▲]

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See detailGlutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function
Kurniawan, Henry; Franchina, Davide G.; Guerra, Luana UL et al

in Cell Metabolism (2020), 31(5), 920--9367

Regulatory T cells (Tregs) maintain immune homeostasis and prevent autoimmunity. Serine stimulates glutathione (GSH) synthesis and feeds into the one-carbon metabolic network (1CMet) essential for ... [more ▼]

Regulatory T cells (Tregs) maintain immune homeostasis and prevent autoimmunity. Serine stimulates glutathione (GSH) synthesis and feeds into the one-carbon metabolic network (1CMet) essential for effector T cell (Teff) responses. However, serine’s functions, linkage to GSH, and role in stress responses in Tregs are unknown. Here, we show, using mice with Treg-specific ablation of the catalytic subunit of glutamate cysteine ligase ( Gclc), that GSH loss in Tregs alters serine import and synthesis and that the integrity of this feedback loop is critical for Treg suppressive capacity. Although Gclc ablation does not impair Treg differentiation, mutant mice exhibit severe autoimmunity and enhanced anti-tumor responses. Gclc-deficient Tregs show increased serine metabolism, mTOR activation, and proliferation but downregulated FoxP3. Limitation of cellular serine in vitro and in vivo restores FoxP3 expression and suppressive capacity of Gclc-deficient Tregs. Our work reveals an unexpected role for GSH in restricting serine availability to preserve Treg functionality. [less ▲]

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See detailGerontagogy Toward Intergenerationality: Dialogical Learning Between Children and Elders
Boulanger, Dany; Albert, Isabelle UL; Marsico, Giuseppina

in Integrative Psychological and Behavioral Science (2020), 54

This paper aims at overcoming the following limits of gerontagogy –particularly with regard to Lemieux’s model: referencing chronological age; delimitating elders’ learning in reference to traits (styles ... [more ▼]

This paper aims at overcoming the following limits of gerontagogy –particularly with regard to Lemieux’s model: referencing chronological age; delimitating elders’ learning in reference to traits (styles, needs, behaviors, etc.) in contrast to children’s learning; overlooking the aging aspect. To do so, we propose to integrate aging and intergenerationality into gerontagogy from a sociocultural, dialogical and historical approach. This establishes the basis for an intergenerational and dialogical approach to elders’ learning. [less ▲]

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See detailXPS Modeling of Immobilized Recombinant Angiogenin and Apoliprotein A1 on Biodegradable Nanofibers
Manakhov, Anton; Permyakova, Elizaveta; Ershov, Sergey UL et al

in Nanomaterials (2020), 10(5), 879

The immobilization of viable proteins is an important step in engineering efficient scaffolds for regenerative medicine. For example, angiogenin, a vascular growth factor, can be considered a neurotrophic ... [more ▼]

The immobilization of viable proteins is an important step in engineering efficient scaffolds for regenerative medicine. For example, angiogenin, a vascular growth factor, can be considered a neurotrophic factor, influencing the neurogenesis, viability, and migration of neurons. Angiogenin shows an exceptional combination of angiogenic, neurotrophic, neuroprotective, antibacterial, and antioxidant activities. Therefore, this protein is a promising molecule that can be immobilized on carriers used for tissue engineering, particularly for diseases that are complicated by neurotrophic and vascular disorders. Another highly important and viable protein is apoliprotein A1. Nevertheless, the immobilization of these proteins onto promising biodegradable nanofibers has not been tested before. In this work, we carefully studied the immobilization of human recombinant angiogenin and apoliprotein A1 onto plasma-coated nanofibers. We developed a new methodology for the quantification of the protein density of these proteins using X-ray photoelectron spectroscopy (XPS) and modeled the XPS data for angiogenin and apoliprotein A1 (Apo-A1). These findings were also confirmed by the analysis of immobilized Apo-A1 using fluorescent microscopy. The presented methodology was validated by the analysis of fibronectin on the surface of plasma-coated poly(ε-caprolactone) (PCL) nanofibers. This methodology can be expanded for other proteins and it should help to quantify the density of proteins on surfaces using routine XPS data treatment. [less ▲]

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See detailCache-aided full-duplex: Delivery time analysis and optimization
Vu, Thang Xuan UL; Trinh, Anh Vu; Chatzinotas, Symeon UL et al

in Wireless Networks (2020)

Edge caching has received much attention as a promising technique to overcome the stringent latency and data-hungry challenges in the future generation wireless networks. Meanwhile, full-duplex (FD ... [more ▼]

Edge caching has received much attention as a promising technique to overcome the stringent latency and data-hungry challenges in the future generation wireless networks. Meanwhile, full-duplex (FD) transmission can improve the spectral efficiency by allowing a node to receive and transmit on the same frequency band simultaneously. In this paper, we investigate the delivery time performance of a cache-aided FD system, in which an edge node, operates in FD mode, serves users via wireless channels and is equipped with a cache memory. Firstly, we derive a closed-form expression for the average delivery time by taking into account the uncertainties of both backhaul and access wireless channels. The derived analysis allows the examination of the impact of the key parameters, e.g., cache size and transmit power. Secondly, a power optimization problem is formulated to minimize the average delivery time. To deal with the non-convexity of the formulated problem, we propose an iterative optimization algorithm based on the bisection method. Finally, numerical results are presented to demonstrate the effectiveness of the proposed algorithm, which can significantly reduce the delivery time compared to the FD reference and the half-duplex counterpart. [less ▲]

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See detailOpinion Statement ECJ-TF 1/2020 on the General Court Decisions of 24 September 2019 in "Starbucks" and "Fiat" on State Aid Granted by Transfer Pricing Rulings
Haslehner, Werner UL; Garcia Prats, Alfredo; Heydt, Volker et al

in European Taxation (2020), 60(5), 222-230

This CFE Opinion Statement, submitted to the EU Institutions on 28 January 2020, discusses the General Court decisions of 24 September 2019 in The Netherlands v. Commission (Starbucks) (Joined Cases C-760 ... [more ▼]

This CFE Opinion Statement, submitted to the EU Institutions on 28 January 2020, discusses the General Court decisions of 24 September 2019 in The Netherlands v. Commission (Starbucks) (Joined Cases C-760/15 and T-636/16) and Luxembourg v. Commission (Fiat Finance and Trade) (Joined Cases T-755/15 and T-759/15), on State aid granted by transfer pricing rulings. [less ▲]

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See detailNAI: Towards Transparent and Usable Semi-Automated Legal Analysis
Libal, Tomer UL; Steen, Alexander UL

in Jusletter IT (2020), 27 Mai 2020

A prototype for automated reasoning over legal documents, called NAI, is presented. It uses formalized representations of legal documents that are created using a graphical editor that is also provided as ... [more ▼]

A prototype for automated reasoning over legal documents, called NAI, is presented. It uses formalized representations of legal documents that are created using a graphical editor that is also provided as part of NAI. The prototype supports several automated reasoning procedures over the given formalizations, including the execution of user queries. The application of NAI is studied using a fragment of the Scottish Smoking Prohibition (Children in Motor Vehicles) Act 2016. [less ▲]

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See detailExponential integrability and exit times of diffusions on sub-Riemannian and metric measure spaces
Thompson, James UL; Thalmaier, Anton UL

in Bernoulli (2020), 26(3), 2202-2225

In this article we derive moment estimates, exponential integrability, concentration inequalities and exit times estimates for canonical diffusions in two settings each beyond the scope of Riemannian ... [more ▼]

In this article we derive moment estimates, exponential integrability, concentration inequalities and exit times estimates for canonical diffusions in two settings each beyond the scope of Riemannian geometry. Firstly, we consider sub-Riemannian limits of Riemannian foliations. Secondly, we consider the non-smooth setting of RCD*(K,N) spaces. In each case the necessary ingredients are an Ito formula and a comparison theorem for the Laplacian, for which we refer to the recent literature. As an application, we derive pointwise Carmona-type estimates on eigenfunctions of Schrodinger operators. [less ▲]

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See detailAge-Related Changes in Pain Perception Are Associated With Altered Functional Connectivity During Resting State
Gonzalez-Roldan, Ana Maria; Terrasa, Juan Lorenzo; Sitges, Carolina et al

in Frontiers in Aging Neuroscience (2020), 12(116),

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See detailThe Energy Consumption of Blockchain Technology: Beyond Myth
Sedlmeir, Johannes; Ulrich Buhl, Hans; Fridgen, Gilbert UL et al

in Business and Information Systems Engineering (2020)

When talking about blockchain technology in academia, business, and society, frequently generalizations are still heared about its – supposedly inherent – enormous energy consumption. This perception ... [more ▼]

When talking about blockchain technology in academia, business, and society, frequently generalizations are still heared about its – supposedly inherent – enormous energy consumption. This perception inevitably raises concerns about the further adoption of blockchain technology, a fact that inhibits rapid uptake of what is widely considered to be a groundbreaking and disruptive innovation. However, blockchain technology is far from homogeneous, meaning that blanket statements about its energy consumption should be reviewed with care. The article is meant to bring clarity to the topic in a holistic fashion,looking beyond claims regarding the energy consumption of Bitcoin, which have, so far, dominated the discussion. [less ▲]

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See detailComment le droit européen déplace les frontières ? La proposition de règlement visant à lever les obstacles juridiques et administratifs à la coopération transfrontalière
Evrard, Estelle UL

in Annales de Géographie (2020), 733-734

To facilitate the daily management of a cross-border project, the European Commission has developed a proposal for a regulation "on the creation of a mechanism to remove legal and administrative obstacles ... [more ▼]

To facilitate the daily management of a cross-border project, the European Commission has developed a proposal for a regulation "on the creation of a mechanism to remove legal and administrative obstacles in a cross-border context". The latter aims to allow the use of a single law in the context of a cross-border project. This contribution uses legal geography to analyse the originality of this proposal. First, it places it in the context of European integration and the objective of territorial cohesion. Then, it suggests that the proposed ECBM Regulation represents a paradigm shift in two respects. First, it sets up an institutional lever enabling border areas to operationalise cross-border projects and build material appropriation of the cross-border area and thus acts in favour of greater spatial justice. Second, it requires national laws to extend its spatial scope (i.e. extraterritoriality). This regulation suggests than that the construction of European territoriality is achieved in border areas by increasing the porosity of the state territory. [less ▲]

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See detailMultichannel Source Separation Using Time-Deconvolutive CNMF
Dias, Thadeu; Alves Martins, Wallace UL; Biscainho, Luiz Wagner

in Journal of Communication and Information Systems (2020), 35(1), 103-112

This paper addresses the separation of audio sources from convolutive mixtures captured by a microphone array. We approach the problem using complex-valued non-negative matrix factorization (CNMF), and ... [more ▼]

This paper addresses the separation of audio sources from convolutive mixtures captured by a microphone array. We approach the problem using complex-valued non-negative matrix factorization (CNMF), and extend previous works by tailoring advanced (single-channel) NMF models, such as the deconvolutive NMF, to the multichannel factorization setup. Further, a sparsity-promoting scheme is proposed so that the underlying estimated parameters better fit the time-frequency properties inherent in some audio sources. The proposed parameter estimation framework is compatible with previous related works, and can be thought of as a step toward a more general method. We evaluate the resulting separation accuracy using a simulated acoustic scenario, and the tests confirm that the proposed algorithm provides superior separation quality when compared to a state-of-the-art benchmark. Finally, an analysis of the effects of the introduced regularization term shows that the solution is in fact steered toward a sparser representation. [less ▲]

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See detailAnalysis of Cooperative Bus Priority at Traffic Signals
Seredynski, Marcin; Laskaris, Georgios UL; Viti, Francesco UL

in IEEE Transactions on Intelligent Transportation Systems (2020), 21(5), 1929-1940

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See detailEditorial
Pigeron-Piroth, Isabelle UL; Belkacem, Rachid

in Les Cahiers de la Grande Région (2020), 2

Après un premier numéro consacré aux évolutions démographiques, ce volume, édité par Rachid Belkacem (Université de Lorraine) et Isabelle Pigeron-Piroth (Université du Luxembourg) interroge les évolutions ... [more ▼]

Après un premier numéro consacré aux évolutions démographiques, ce volume, édité par Rachid Belkacem (Université de Lorraine) et Isabelle Pigeron-Piroth (Université du Luxembourg) interroge les évolutions actuelles et futures du marché du travail transfrontalier. Pour traiter ces différents aspects, cinq articles, constituant des synthèses de travaux réalisés par divers instituts (LISER, ADEM et STATEC) aborderont les questions de compétences recherchées dans la Grande Région, les inadéquations entre offres et demandes de travail, mais aussi les nouveaux modèles d’organisation du travail (télétravail), ou de croissance (croissance qualitative), reflets de ces équations difficiles à résoudre,mais aussi des problématiques d’actualité liées à la crise sanitaire . [less ▲]

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See detailPolyhedra inscribed in a quadric
Danciger, Jeffrey; Maloni, Sara; Schlenker, Jean-Marc UL

in Inventiones Mathematicae (2020), 221(1), 237-300

We study convex polyhedra in three-space that are inscribed in a quadric surface. Up to projective transformations, there are three such surfaces: the sphere, the hyperboloid, and the cylinder. Our main ... [more ▼]

We study convex polyhedra in three-space that are inscribed in a quadric surface. Up to projective transformations, there are three such surfaces: the sphere, the hyperboloid, and the cylinder. Our main result is that a planar graph $\Gamma$ is realized as the $1$--skeleton of a polyhedron inscribed in the hyperboloid or cylinder if and only if $\Gamma$ is realized as the $1$--skeleton of a polyhedron inscribed in the sphere and $\Gamma$ admits a Hamiltonian cycle. Rivin characterized convex polyhedra inscribed in the sphere by studying the geometry of ideal polyhedra in hyperbolic space. We study the case of the hyperboloid and the cylinder by parameterizing the space of convex ideal polyhedra in anti-de Sitter geometry and in half-pipe geometry. Just as the cylinder can be seen as a degeneration of the sphere and the hyperboloid, half-pipe geometry is naturally a limit of both hyperbolic and anti-de Sitter geometry. We promote a unified point of view to the study of the three cases throughout. [less ▲]

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See detailAt the boundaries of institutional theorizing: Individual entrepreneurship in episodes of regulatory change
Löhlein, Lukas; Muessig, Anke UL

in Accounting, Organizations and Society (2020), 83

We analyse the institutional dynamics surrounding the establishment of independent audit oversight in Germany from 1997 to 2016. Complementing prior works, which have focused on countries where the global ... [more ▼]

We analyse the institutional dynamics surrounding the establishment of independent audit oversight in Germany from 1997 to 2016. Complementing prior works, which have focused on countries where the global demand for independent regulation coincides with the domestic erosion of public trust in professional self-regulation, we investigate regulatory change in a context featuring strong trust in the accounting profession. To analyse the accounting establishment’s response to expanding global standards of accounting regulation and the escalating resistance of small accounting firms, as orchestrated by one individual, we mobilize a Bourdieusian field perspective and the literature on institutional entrepreneurship. By demonstrating how intra-professional conflict has increasingly eroded the establishment’s capital to reproduce its hegemonic field position and keep the regulator at distance, our case provides a counterpoint to prior research, which suggests that oversight is mainly the product of negotiations between a unified profession and the regulatory authority. Examining a rare instance of individual entrepreneurship also enables us to engage in a theory-testing process on the explanatory power of institutional ambiguitiesdthe subjectively perceived ruptures and contradictions within established social arrangementsdfor agency. Our findings suggest that ongoing encounters with institutional ambiguities result in varying disposition to activism. In this way, while acknowledging agency as a cause of field reproduction and change, our analysis shifts attention towards the relational, temporal, and transformational institutional dynamics that constitute distinct modes of agency. By identifying empirical residuals that seem to escape theorization, we also reveal the limits of institutional theorizing. [less ▲]

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See detailOpening minds to translanguaging pedagogies
Kirsch, Claudine UL

in System (2020)

Translanguaging pedagogies promise to capitalise on students’ language backgrounds, improve their academic achievements and address social inequalities. While research studies in monolingual, bilingual ... [more ▼]

Translanguaging pedagogies promise to capitalise on students’ language backgrounds, improve their academic achievements and address social inequalities. While research studies in monolingual, bilingual and multilingual contexts testify to the benefits of translanguaging for learning, well-being and identity-building, few studies focus on early childhood education and the use of more than two languages. Furthermore, little is known about the implementation of translanguaging pedagogies and the challenges faced by professionals. This article is based on a longitudinal research project which offered a professional development course to develop multilingual pedagogies in early childhood education in Luxembourg, where 63.7% of the 4-year-olds do not speak Luxembourgish as their home language. The article presents challenges which three practitioners faced when implementing a translanguaging pedagogy in their preschool classes as well as the ways in which they overcame them. They changed their negative stance to multilingual education, developed a social-constructivist leaning environment and monitored their language use. The findings shed light on the complexities of the implementation process and the support needed for professional learning. [less ▲]

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See detailTaxing intangible assets: issues and challenges for a digital Europe
Danescu, Elena UL

in Internet Histories: Digital Technology, Culture and Society (2020)

Value creation is increasingly based on knowledge and intangible assets. This trend has gained momentum with the development of the service sector, the rise in competition as a result of globalisation and ... [more ▼]

Value creation is increasingly based on knowledge and intangible assets. This trend has gained momentum with the development of the service sector, the rise in competition as a result of globalisation and deregulation, and the impact of the digital revolution.Innovation has proven to be a key factor in economic growth. In the aftermath of the global crisis; public authorities, states, European organisations (the EU and the Council of Europe) and transnational and international bodies (UN, OECD, WTO, IMF) have a major role to play in regulating the multi-dimensional potential of global growth and defending against the problems inherent in these new, unavoidable processes.The EU sees the Digital Single Market (DSM) and the capital markets union as two priority aspects in the completion of the European Single Market (ESM). To cite this article: Elena Danescu (2020): Taxing intangible assets: issues and challenges for a digital Europe, Internet Histories, DOI: 10.1080/24701475.2020.1749806 [less ▲]

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See detailHuR/ELAVL1 drives malignant peripheral nerve sheath tumour growth and metastasis
del Sol Mesa, Antonio UL

in Journal of Clinical Investigation (2020)

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See detailViviane Reding on her action in the field of the information society and media (2004-2010)
Danescu, Elena UL

in Internet Histories: Digital Technology, Culture and Society (2020)

The following pages are taken from a long interview (more than eight hours of footage in total) that Viviane Reding granted us in 2015 in connection with the “Pierre Werner and Europe” research project ... [more ▼]

The following pages are taken from a long interview (more than eight hours of footage in total) that Viviane Reding granted us in 2015 in connection with the “Pierre Werner and Europe” research project. Drawing on more than 40 years’ experience in politics, Viviane Reding spoke about her career, the role of Luxembourg and Luxembourgers in the European integration process, and various key events in which she played a part. In these extracts, she discusses her role as a member of the first and second Barroso Commissions (2004-2009 and 2010-2014) and her efforts to help build an information and knowledge society in Europe, one that serves citizens and protects their rights and fundamental freedoms. Her achievements in this respect include capping mobile phone roaming charges (they were subsequently abolished in 2017), advocating for the introduction of a single emergency number (112) in all EU countries, launching the Europeana digital library, and spearheading a programme to use technological innovation for climate and energy solutions. She also describes the process of developing a Digital Agenda for Europe to improve the continent’s digital competitiveness compared with the United States, China and Japan – a complex and challenging task given the context of globalisation and the divergent interests of the various stakeholders (research, industry, consumers, etc.). Finally, she mentions the reform of personal data protection that she initiated (leading to the GDPR, adopted in April 2016). [less ▲]

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See detailPharmacoresponse in genetic generalized epilepsy: a genome-wide association study
Wolking, Stefan; Schulz, Herbert; Nies, Anne T. et al

in Pharmacogenomics (2020), 0(0),

Aim: Pharmacoresistance is a major burden in epilepsy treatment. We aimed to identify genetic biomarkers in response to specific antiepileptic drugs (AEDs) in genetic generalized epilepsies (GGE ... [more ▼]

Aim: Pharmacoresistance is a major burden in epilepsy treatment. We aimed to identify genetic biomarkers in response to specific antiepileptic drugs (AEDs) in genetic generalized epilepsies (GGE). Materials  methods: We conducted a genome-wide association study (GWAS) of 3.3 million autosomal SNPs in 893 European subjects with GGE – responsive or nonresponsive to lamotrigine, levetiracetam and valproic acid. Results: Our GWAS of AED response revealed suggestive evidence for association at 29 genomic loci (p <10-5) but no significant association reflecting its limited power. The suggestive associations highlight candidate genes that are implicated in epileptogenesis and neurodevelopment. Conclusion: This first GWAS of AED response in GGE provides a comprehensive reference of SNP associations for hypothesis-driven candidate gene analyses in upcoming pharmacogenetic studies. [less ▲]

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See detailEnergy- and Cost-Efficient Physical Layer Security in the Era of IoT: The Role of Interference
Wei, Z.; Masouros, C.; Liu, F. et al

in IEEE Communications Magazine, title=Energy- and Cost-Efficient Physical Layer Security in the Era of IoT: The Role of Interference (2020), 58(4), 81-87

IoT is emerging as the future evolution of the Internet, aiming to provide connectivity for everyone and everything. Since IoT is expected to carry important and private information, a high level of PHY ... [more ▼]

IoT is emerging as the future evolution of the Internet, aiming to provide connectivity for everyone and everything. Since IoT is expected to carry important and private information, a high level of PHY security is critical for wireless communications in IoT, as a complement for traditional security techniques that are employed at high layers. In this overview, we examine the recent interest in energy-efficient and cost-efficient PHY solutions for securing downlink IoT transmission through interference exploitation. This exciting line of research departs from conventional interference cancellation, and judiciously employs the inherent interference as a useful element for LUs while obstructing the eavesdropping of information. We first discuss the concept of CI, and then elaborate the fundamental CI signal design that employs the traditionally undesired interference as a constructive element to LUs while ensuring they are destructive to potential Eves. Subsequently, we illustrate several low-hardware-cost techniques to inherit the advantage of CI in an energy- and cost-efficient manner, from the perspective of HBF and DM. This family of techniques brings a disruptive vision of interference management for securing wireless communications with an eye on low-cost and hardware-constrained devices tailored for IoT systems. [less ▲]

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See detailBi-allelic GAD1 variants cause a neonatal onset syndromic developmental and epileptic encephalopathy
Chatron, Nicolas; Becker, Felicitas; Morsy, Herba et al

in Brain: a Journal of Neurology (2020)

Developmental and Epileptic Encephalopathies are a heterogeneous group of early-onset epilepsy syndromes dramatically impairing neurodevelopment. Modern genomic technologies have revealed a number of ... [more ▼]

Developmental and Epileptic Encephalopathies are a heterogeneous group of early-onset epilepsy syndromes dramatically impairing neurodevelopment. Modern genomic technologies have revealed a number of monogenic origins and opened the door to therapeutic hopes. Here we describe a new syndromic developmental and epileptic encephalopathies caused by bi-allelic loss of function variants in GAD1, as presented by eleven patients from 6 independent consanguineous families. Seizure onset occurred in the two first months of life in all patients. All 10 patients from whom early disease history was available, presented seizure onset in the first month of life, mainly consisting of epileptic spasms or myoclonic seizures. Early electroencephalography showed suppression-burst or pattern of burst attenuation or hypsarrhythmia if only recorded in the post-neonatal period. Eight patients had joint contractures and/or pes equinovarus. Seven patients presented a cleft palate and two also had an omphalocele, reproducing the phenotype of the knockout Gad1-/- mouse model. Four patients died before four years of age. GAD1 encodes the glutamate decarboxylase enzyme GAD67, a critical actor of the γ-aminobutyric acid (GABA) metabolism as it catalyzes the decarboxylation of glutamic acid to form GABA. Our findings evoke a novel syndrome related to GAD67 deficiency, characterized by the unique association of developmental and epileptic encephalopathies, cleft palate, joint contractures and/or omphalocele. [less ▲]

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See detailHeranführung an die mehrsprachige Pädagogik durch Filmaufnahmen in der Lehrerausbildung in Luxemburg
Kirsch, Claudine UL

in Zeitschrift für Interkulturellen Fremdsprachenunterricht (2020), 25(1), 22

Aufgrund von gesellschaftlichen, sprach- und bildungspolitischen Entwicklungen soll mehrsprachige Bildung ein fester Bestandteil des Schul- und Vorschulunterrichts sein. Es gilt deshalb, angehende ... [more ▼]

Aufgrund von gesellschaftlichen, sprach- und bildungspolitischen Entwicklungen soll mehrsprachige Bildung ein fester Bestandteil des Schul- und Vorschulunterrichts sein. Es gilt deshalb, angehende LehrerInnen auf diese Neuerung vorzubereiten und ihnen beim Aneignen von Wissen und bei der Reflexion ihrer Haltungen zu helfen. Zu diesem Zweck wurden Filmaufnahmen aus einer empirischen Forschung zur frühen mehrsprachigen Bildung in der Lehrerausbildung in Luxemburg eingesetzt. Ein Fragebogen und Gruppeninterviews mit den Studierenden zeigen, dass sie durch das Filmmaterial neues Wissen erwarben und an ihren Einstellungen arbeiteten. Die Veranschaulichung in den Filmen, die theoriegeleiteten Diskussionen im Seminar und die tiefe Auseinandersetzung und Reflexion der Studierenden waren lernförderlich. Societal developments, language policies and new understandings of language learning call for multilingual education in schools. Prospective teachers need to be prepared for this change and develop a stance and knowledge that further multilingualism. To promote learning, videos of a research project on multilingual pedagogies in early years were used in teacher education in Luxembourg. A questionnaire and group interviews with students showed that they developed new knowledge and worked on their stance towards multilingual education. The illustrations in the videos, the theory-led discussions as well as the students’ deep engagement and reflection promoted learning. [less ▲]

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See detailMissing heritability in Parkinson’s disease: the emerging role of non‑coding genetic variation
Ohnmacht, Jochen UL; May, Patrick UL; Sinkkonen, Lasse UL et al

in Journal of Neural Transmission (2020)

Parkinson's disease (PD) is a neurodegenerative disorder caused by a complex interplay of genetic and environmental factors. For the stratification of PD patients and the development of advanced clinical ... [more ▼]

Parkinson's disease (PD) is a neurodegenerative disorder caused by a complex interplay of genetic and environmental factors. For the stratification of PD patients and the development of advanced clinical trials, including causative treatments, a better understanding of the underlying genetic architecture of PD is required. Despite substantial efforts, genome-wide association studies have not been able to explain most of the observed heritability. The majority of PD-associated genetic variants are located in non-coding regions of the genome. A systematic assessment of their functional role is hampered by our incomplete understanding of genotype-phenotype correlations, for example through differential regulation of gene expression. Here, the recent progress and remaining challenges for the elucidation of the role of non-coding genetic variants is reviewed with a focus on PD as a complex disease with multifactorial origins. The function of gene regulatory elements and the impact of non-coding variants on them, and the means to map these elements on a genome-wide level, will be delineated. Moreover, examples of how the integration of functional genomic annotations can serve to identify disease-associated pathways and to prioritize disease- and cell type-specific regulatory variants will be given. Finally, strategies for functional validation and considerations for suitable model systems are outlined. Together this emphasizes the contribution of rare and common genetic variants to the complex pathogenesis of PD and points to remaining challenges for the dissection of genetic complexity that may allow for better stratification, improved diagnostics and more targeted treatments for PD in the future. [less ▲]

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See detailInduced pluripotent stem cell line (LCSBi001-A) derived from a patient with Parkinson's disease carrying the p.D620N mutation in VPS35
Larsen, Simone UL; Hanss, Zoé UL; Cruciani, Gérald UL et al

in Stem Cell Research (2020)

Fibroblasts were obtained from a 76 year-old man diagnosed with Parkinson's disease (PD). The disease is caused by a heterozygous p.D620N mutation in VPS35. Induced pluripotent stem cells (iPSCs) were ... [more ▼]

Fibroblasts were obtained from a 76 year-old man diagnosed with Parkinson's disease (PD). The disease is caused by a heterozygous p.D620N mutation in VPS35. Induced pluripotent stem cells (iPSCs) were generated using the CytoTune™-iPS 2.0 Sendai Reprogramming Kit (Thermo Fisher Scientific). The presence of the c.1858G > A base exchange in exon 15 of VPS35 was confirmed by Sanger sequencing. The iPSCs are free of genomically integrated reprogramming genes, express pluripotency markers, display in vitro differentiation potential to the three germ layers and have karyotypic integrity. Our iPSC line will be useful for studying the impact of the p.D620N mutation in VPS35 in vitro. [less ▲]

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See detailControlling electrical and optical properties of zinc oxide thin films grown by thermal atomic layer deposition with oxygen gas
Nguyen, Tai; Adjeroud, Noureddine; Guennou, Mael UL et al

in Results in Materials (2020), 6

The preparation of ZnO thin films with controlled electrical resistivity and optical properties is often challenged by the presence of defects, such as oxygen vacancies or interstitial zinc. Here, we ... [more ▼]

The preparation of ZnO thin films with controlled electrical resistivity and optical properties is often challenged by the presence of defects, such as oxygen vacancies or interstitial zinc. Here, we investigate the material properties of ZnO polycrystalline thin films prepared by thermal Atomic Layer Deposition (ALD) with the presence of molecular oxygen pulsing during the growth. By means of structural, electrical and optical characterizations, we identify key growth parameters of this unusual ALD process. Unexpectedly, the influence of oxygen molecules on the crystallography, microstructure and morphology of ZnO films is significant from hundred-nanometers to micrometer thick film. The electrical resistivity of the films grown with oxygen gas shows a dramatic increase from 3 to 4 orders of magnitude. Additionally, photoluminescence measurements reveal that deep-level emissions caused by defects located deep in the band gap can be reduced by applying an adequate pulsing of oxygen gas during the process. Finally, we conclude with a discussion about the degree of consistency between the chemical composition, the inner strain and the optical and electrical properties of the films obtained with the different thermodynamic parameters of growth. Several hypotheses are discussed in order to understand the dominance of (002) orientation in the presence of oxygen during the ALD growth process. [less ▲]

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See detailAgainst mass media trends: Minority growth in cultural globalization
Cosenza, M. G.; Gavidia Borrero, Marino Eliezer UL; Gonzalez-Avella, J. C.

in PLoS ONE (2020)

We investigate the collective behavior of a globalized society under the influence of endogenous mass media trends. The mass media trend is a global field corresponding to the statistical mode of the ... [more ▼]

We investigate the collective behavior of a globalized society under the influence of endogenous mass media trends. The mass media trend is a global field corresponding to the statistical mode of the states of the agents in the system. The interaction dynamics is based on Axelrod’s rules for the dissemination of culture. We find situations where the largest minority group, possessing a cultural state different from that of the predominant trend transmitted by the mass media, can grow to almost half of the size of the population. We show that this phenomenon occurs when a critical number of long-range connections are present in the underlying network of interactions. We have numerically characterized four phases on the space of parameters of the system: an ordered phase; a semi-ordered phase where almost half of the population consists of the largest minority in a state different from that of the mass media; a disordered phase; and a chimera-like phase where one large domain coexists with many very small domains. [less ▲]

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See detailMagnetic structure factor of correlated moments in small-angle neutron scattering
Honecker, Dirk UL; Fernández Barquín, Luis; Bender, Philipp Florian UL

in Physical Review. B, Condensed Matter and Materials Physics (2020), 101(13), 134401

The interplay between structural and magnetic properties of nanostructured magnetic materials allows one to realize unconventional magnetic effects, which results in a demand for experimental techniques ... [more ▼]

The interplay between structural and magnetic properties of nanostructured magnetic materials allows one to realize unconventional magnetic effects, which results in a demand for experimental techniques to determine the magnetization profile with nanoscale resolution. Magnetic small-angle neutron scattering (SANS) probes both the chemical and magnetic nanostructure and is thus a powerful technique, e.g., for the characterization of magnetic nanoparticles. Here, we show that the conventionally used particle-matrix approach to describe SANS of magnetic particle assemblies, however, leads to a flawed interpretation. As a remedy, we provide general expressions for the field-dependent two-dimensional magnetic SANS cross section of correlated moments. It is shown that for structurally disordered ensembles the magnetic structure factor is in general, and contrary to common assumptions, (i) anisotropic also in zero field and (ii) that even in saturation the magnetic structure factor deviates from the nuclear one. These theoretical predictions explain qualitatively the intriguing experimental, polarized SANS data of an ensemble of dipolar-coupled iron oxide nanoparticles. [less ▲]

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See detailFirst-principles modeling of chemistry in mixed solvents: Where to go from here?
Maldonado, Alex; Basdogan, Yasemin; Berryman, Josh UL et al

in Journal of Chemical Physics (2020), 152

Mixed solvents (i.e., binary or higher order mixtures of ionic or nonionic liquids) play crucial roles in chemical syntheses, separations, and electrochemical devices because they can be tuned for ... [more ▼]

Mixed solvents (i.e., binary or higher order mixtures of ionic or nonionic liquids) play crucial roles in chemical syntheses, separations, and electrochemical devices because they can be tuned for specific reactions and applications. Apart from fully explicit solvation treatments that can be difficult to parameterize or computationally expensive, there is currently no well-established first-principles regimen for reliably modeling atomic-scale chemistry in mixed solvent environments. We offer our perspective on how this process could be achieved in the near future as mixed solvent systems become more explored using theoretical and computational chemistry. We first outline what makes mixed solvent systems far more complex compared to single-component solvents. An overview of current and promising techniques for modeling mixed solvent environments is provided. We focus on so-called hybrid solvation treatments such as the conductor-like screening model for real solvents and the reference interaction site model, which are far less computationally demanding than explicit simulations. We also propose that cluster-continuum approaches rooted in physically rigorous quasi-chemical theory provide a robust, yet practical, route for studying chemical processes in mixed solvents. [less ▲]

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See detailThe Role of Cultural Heritage in 21st-Century Music Education
Buzás, Zsuzsa; Sagrillo, Damien UL

in Civic Review (2020), 15(2019), 317-328

Cul­tural her­it­age is an in­teg­ral part of Hun­garian music edu­ca­tion. Folk tra­di­tions and folk songs are taught in every school, from the cap­ital city to the smal­lest vil­lages. Thou­sands of ... [more ▼]

Cul­tural her­it­age is an in­teg­ral part of Hun­garian music edu­ca­tion. Folk tra­di­tions and folk songs are taught in every school, from the cap­ital city to the smal­lest vil­lages. Thou­sands of songs were col­lec­ted by Zoltán Kodály and Béla Bartók, who ad­op­ted them in their clas­sical com­pos­i­tions. With this they earned fame for Hun­garian folk music and tra­di­tions. Zoltán Kodály also com­posed a series of music read­ing ma­ter­i­als, mainly based on folk songs, which is cur­rently used on all levels of Hun­garian music edu­ca­tion. Not only the Kodály concept, but the Táncház-method was also se­lec­ted in the Re­gister of Good Safe­guard­ing Prac­tices of UN­ESCO Cul­tural Her­it­age. In our di­gital age, the net-gen­er­a­tion, un­like the pre­vi­ous stu­dent pop­u­la­tions, can have dif­fer­ent habits, which is the reason why stu­dents’ music skills were tested with tech­no­logy-based meth­ods and tools. They are sur­roun­ded by pop­u­lar media; however, the value that folk tra­di­tion of­fers should be in­ev­it­able in their edu­ca­tion. The find­ings of our re­search provides input for the edu­ca­tional sys­tem about Hun­garian stu­dents’s music lit­er­acy, and their fa­mili­ar­ity with its vari­ous ele­ments, es­pe­cially with cer­tain com­pon­ents of their cul­tural her­it­age. [less ▲]

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See detailIntra-household allocation with shared expenditure choices: experimental evidence from Filipino migrants
Joxhe, Majlinda UL; De Arcangelis, Giuseppe

in Review of Economics of the Household (2020)

This paper shows that sharing information concerning expenditure choices between a migrant and the recipient affects the migrant’s allocation patterns. In a lab-in-the-field experiment, Filipino migrants ... [more ▼]

This paper shows that sharing information concerning expenditure choices between a migrant and the recipient affects the migrant’s allocation patterns. In a lab-in-the-field experiment, Filipino migrants are asked to earmark an in-kind budget to be delivered to their most closely connected household (MCCH). When the MCCH is fully aware of the migrant’s decisions (i.e., symmetric information), we observe that the migrant raises the portion for consumption goods in the range of 10.0-10.5% with respect to the case when the migrant’s choices are not disclosed (i.e., asymmetric information). Moreover, when sharing information, the migrant relies on more involvement of the recipient household and lowers by 7-9% the allocation to expenses she could monitor ex-post more strictly. The former result is consistent with the signaling motive, whereas the latter supports the presence of strategic behavior by the migrant remitter. These findings are more significant for intra- rather than inter-household transfers and provide insights for conditional cash transfer policies. [less ▲]

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See detailÜber die Ambivalenz des Teilens. Zur Rolle der Sharing Economy in Postwachstumsansätzen
Schulz, Christian UL

in Politische Ökologie (2020), 35(160), 66-71

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See detailOpinion Statement ECJ TF 4/2019 on the ECJ Decision of 26 February 2019 in X-GmbH (Case C-135/17), Concerning the Application of the German CFC Legislation in Relation to Third Countries
Haslehner, Werner UL; García Prats, Alfredo; Heydt, Volker et al

in European Taxation (2020), 60(4), 152-157

This CFE Opinion Statement, submitted to the EU institutions on 12 December 2019, comments on the decision in X-GmbH (Case C-135/17), in respect of which the Court of Justice of the European Union (Grand ... [more ▼]

This CFE Opinion Statement, submitted to the EU institutions on 12 December 2019, comments on the decision in X-GmbH (Case C-135/17), in respect of which the Court of Justice of the European Union (Grand Chamber) (ECJ) delivered its decision on 26 February 2019. In general terms, the ECJ largely followed the Opinion given by Advocate General Mengozzi on 5 December 2018. [less ▲]

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See detailAssociative, idempotent, symmetric, and order-preserving operations on chains
Devillet, Jimmy UL; Teheux, Bruno UL

in Order: A Journal on the Theory of Ordered Sets and its Applications (2020), 37(1), 45-58

We characterize the associative, idempotent, symmetric, and order-preserving operations on (finite) chains in terms of properties of (the Hasse diagram of) their associated semilattice order. In ... [more ▼]

We characterize the associative, idempotent, symmetric, and order-preserving operations on (finite) chains in terms of properties of (the Hasse diagram of) their associated semilattice order. In particular, we prove that the number of associative, idempotent, symmetric, and order-preserving operations on an n-element chain is the nth Catalan number. [less ▲]

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See detailModel Checking MITL formulae on Timed Automata: a Logic-Based Approach
Menghi, Claudio UL; Bersani, Marcello; Rossi, Matteo et al

in ACM Transactions on Computational Logic (2020), 21(3),

Timed Automata (TA) is de facto a standard modelling formalism to represent systems when the interest is the analysis of their behaviour as time progresses. This modelling formalism is mostly used for ... [more ▼]

Timed Automata (TA) is de facto a standard modelling formalism to represent systems when the interest is the analysis of their behaviour as time progresses. This modelling formalism is mostly used for checking whether the behaviours of a system satisfy a set of properties of interest. Even if efficient model-checkers for Timed Automata exist, these tools are not easily configurable. First, they are not designed to easily allow adding new Timed Automata constructs, such as new synchronization mechanisms or communication procedures, but they assume a fixed set of Timed Automata constructs. Second, they usually do not support the Metric Interval Temporal Logic (MITL) and rely on a precise semantics for the logic in which the property of interest is specified which cannot be easily modified and customized. Finally, they do not easily allow using different solvers that may speed up verification in different contexts. This paper presents a novel technique to perform model checking of Metric Interval Temporal Logic (MITL) properties on TA. The technique relies on the translation of both the TA and the MITL formula into an intermediate Constraint LTL over clocks (CLTLoc) formula which is verified through an available decision procedure. The technique is flexible since the intermediate logic allows the encoding of new semantics as well as new TA constructs, by just adding new CLTLoc formulae. Furthermore, our technique is not bound to a specific solver as the intermediate CLTLoc formula can be verified using different procedures. [less ▲]

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See detailSevere metabolic alterations in liver cancer lead to ERK pathway activation and drug resistance
Nwosu, Zeribe Chike; Piorońska, Weronika; Battello, Nadia UL et al

in EBioMedicine (2020)

Background: The extracellular signal-regulated kinase (ERK) pathway regulates cell growth, and is hyper-activated and associated with drug resistance in hepatocellular carcinoma (HCC). Metabolic pathways ... [more ▼]

Background: The extracellular signal-regulated kinase (ERK) pathway regulates cell growth, and is hyper-activated and associated with drug resistance in hepatocellular carcinoma (HCC). Metabolic pathways are profoundly dysregulated in HCC. Whether an altered metabolic state is linked to activated ERK pathway and drug response in HCC is unaddressed. Methods: We deprived HCC cells of glutamine to induce metabolic alterations and performed various assays, including metabolomics (with 13C-glucose isotope tracing), microarray analysis, and cell proliferation assays. Glutamine-deprived cells were also treated with kinase inhibitors (e.g. Sorafenib, Erlotinib, U0126 amongst other MEK inhibitors). We performed bioinformatics analysis and stratification of HCC tumour microarrays to determine upregulated ERK gene signatures in patients. Findings: In a subset of HCC cells, the withdrawal of glutamine triggers a severe metabolic alteration and ERK phosphorylation (pERK). This is accompanied by resistance to the anti-proliferative effect of kinase inhibitors, despite pERK inhibition. High intracellular serine is a consistent feature of an altered metabolic state and contributes to pERK induction and the kinase inhibitor resistance. Blocking the ERK pathway facilitates cell proliferation by reprogramming metabolism, notably enhancing aerobic glycolysis. We have identified 24 highly expressed ERK gene signatures that their combined expression strongly indicates a dysregulated metabolic gene network in human HCC tissues. Interpretation: A severely compromised metabolism lead to ERK pathway induction, and primes some HCC cells to pro-survival phenotypes upon ERK pathway blockade. Our findings offer novel insights for understanding, predicting and overcoming drug resistance in liver cancer patients. [less ▲]

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See detailHarnessing Public Institutions for Labour Law Enforcement. Embedding a Transnational Labour Inspectorate within the ILO
Garcia Munoz Alhambra, Manuel Antonio UL; Ter Haar, Beryl; Kun, Attila

in International Organizations Law Review (2020), 17(1), 233260

The paper explores how to integrate a Transnational Labour Inspectorate (‘TLI’) dealing with transnational private instruments of Multinational Enterprises (‘MNEs’) into the International Labour ... [more ▼]

The paper explores how to integrate a Transnational Labour Inspectorate (‘TLI’) dealing with transnational private instruments of Multinational Enterprises (‘MNEs’) into the International Labour Organization (‘ILO’). After exploring monitoring initiatives with roots in public international organizations, we will argue that from an international law perspective on international legal personality such activities can be justified. Under the qualification of ‘subject normation’, as we dub these activities, we will argue that the ILO is the best situated locus to embed a system to inspect commitments MNEs voluntary adhere to in their CSR strategies, including Global Framework Agreements. Finally, we explain how the TLI as we envisage it could fit within the existing system of enforcement and compliance monitoring of the ILO. [less ▲]

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See detailActivism on and off the bench: Pierre Pescatore and the law of integration
Fritz, Vera UL

in Common Market Law Review (2020), 57(02), 475-502

This article examines the life and career of Pierre Pescatore, one of the most prominent, but also controversial, promoters of European Community law. Drawing on extensive archive material, as well as ... [more ▼]

This article examines the life and career of Pierre Pescatore, one of the most prominent, but also controversial, promoters of European Community law. Drawing on extensive archive material, as well as interviews with relatives, it aims at understanding how and why he left such a strong footprint on the development of Community, later EU, law, both as a judge at the European Court of Justice and as a law scholar. Going beyond a one-man story, the article situates him in the broader context of the 1970s bench of judges in order to understand the so-called “activism” which the ECJ revealed during this decade. Thus, looking through the lens of one of the leading figures of the Court, it provides new explanations as to why the ECJ’s case law was so provocatively pro-integrationist during the 1970s. [less ▲]

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See detailPractical Constraint Solving for Generating System Test Data
Soltana, Ghanem; Sabetzadeh, Mehrdad UL; Briand, Lionel UL

in ACM Transactions on Software Engineering and Methodology (2020), 29(2), 111-1148

The ability to generate test data is often a necessary prerequisite for automated software testing. For the generated data to be fit for its intended purpose, the data usually has to satisfy various ... [more ▼]

The ability to generate test data is often a necessary prerequisite for automated software testing. For the generated data to be fit for its intended purpose, the data usually has to satisfy various logical constraints. When testing is performed at a system level, these constraints tend to be complex and are typically captured in expressive formalisms based on first-order logic. Motivated by improving the feasibility and scalability of data generation for system testing, we present a novel approach, whereby we employ a combination of metaheuristic search and Satisfiability Modulo Theories (SMT) for constraint solving. Our approach delegates constraint solving tasks to metaheuristic search and SMT in such a way as to take advantage of the complementary strengths of the two techniques. We ground our work on test data models specified in UML, with OCL used as the constraint language. We present tool support and an evaluation of our approach over three industrial case studies. The results indicate that, for complex system test data generation problems, our approach presents substantial benefits over the state of the art in terms of applicability and scalability. [less ▲]

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See detailKeimzellen für die Transformation. Postwachstum und Raumentwicklung
Schmid, Benedikt; Schulz, Christian UL; Weck, Sabine

in Politische Ökologie (2020), 38(160), 19-26

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See detailA Multilateral Interpretation of the Multilateral Instrument (and Covered Tax Agreements)?
Haslehner, Werner UL

in Bulletin for International Taxation (2020), 74(4/5),

The analysis of the multilateral nature of the interpretation processes created by the MLI shows that very little “true multilateralism” arises from its adoption. At its core, the international tax system ... [more ▼]

The analysis of the multilateral nature of the interpretation processes created by the MLI shows that very little “true multilateralism” arises from its adoption. At its core, the international tax system remains fragmented and built on bilateral agreements, with only a thin overlay of multilateral agreement on selected issues. The MLI does not set up a multilateral dispute resolution mechanism. The Conference of the Parties as the only true multilateral body created by the MLI plays a very small – if any – role in the interpretation and application of tax treaty rules. Neither has the MLI produced a system where national courts would have a stronger basis to enforce the harmonious interpretation of treaty terms in both contracting states (let alone among all Parties to the MLI) beyond the general appeal of such approach that already exists prior to – and outside the scope of – the MLI. If a coherent interpretation of CTAs with a view to achieve something like the elusive “single tax principle” was indeed a goal behind the project as a whole, the rules on interpretation applicable following the MLI’s adoption do not amount to a codification of that ideal, although the MLI can, in specific circumstances, have an interpretative effect on tax treaties even where it does not result in a modification of the norms in that treaty. Decision harmony among courts in different countries, therefore, remains an ideal that cannot be based in substance on the existence of the MLI. [less ▲]

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See detailPassivation of the CuInSe2 surface via cadmium pre-electrolyte treatment
Kameni Boumenou, Christian UL; Babbe, Finn; Elizabeth, Amala et al

in Physical Review Materials (2020)

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See detailEnhancing Bus Holding Control Using Cooperative ITS
Laskaris, Georgios; Seredynski, Marcin; Viti, Francesco UL

in IEEE Transactions on Intelligent Transportation Systems (2020), 21(4), 1767-1778

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See detail“The internet and the European market” from a multidisciplinary perspective: a “round-doc” discussion
Schafer, Valerie UL; Fickers, Andreas UL; Howarth, David UL et al

in Internet Histories: Digital Technology, Culture and Society (2020), (2),

Received 24 February 2020 Accepted 28 February 2020 KEYWORDS EU Market; Internet; Digital Market; Governance; Digital Europe; Regulation ABSTRACT David Howarth, Francesca Musiani, Julia Pohle and Dwayne ... [more ▼]

Received 24 February 2020 Accepted 28 February 2020 KEYWORDS EU Market; Internet; Digital Market; Governance; Digital Europe; Regulation ABSTRACT David Howarth, Francesca Musiani, Julia Pohle and Dwayne Winseck were invited to discuss the main topic of this special issue, “The internet and the EU market.” This conversation at the crossroads of several research areas (communication studies, soci- ology, science and technology studies and political science) brought together leading experts who shared their experience, research and expertise on the internet, European integration, gov- ernance issues, etc. They referred to several topics that are addressed in the papers in this issue, such as the taxation of digital services, net neutrality and the openness of networks, as they discussed questions related to the realities and limits of the notion of “Digital Europe”, changing discourses on the EU’s digital economy, the concept of European governance and the turning points and key events in the relationship between the internet and the EU market since the 1990s. [less ▲]

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See detailGuest Editorial Introduction of the Special Issue on Management of Future Motorway and Urban Traffic Systems
Ciuffo, Biagio; Roncoli, Claudio; Viti, Francesco UL

in IEEE Transactions on Intelligent Transportation Systems (2020), 21(4), 1631-1634

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See detailA DEM modeling of biomass fast pyrolysis in a double auger reactor
Qi, Fenglei UL; Wright, Mark

in International Journal of Heat and Mass Transfer (2020), 150

Thermochemical conversion of biomass via fast pyrolysis is a proven pathway to product low-carbon crude bio-oils. In this research, an extended discrete element method (DEM) is proposed for simulating ... [more ▼]

Thermochemical conversion of biomass via fast pyrolysis is a proven pathway to product low-carbon crude bio-oils. In this research, an extended discrete element method (DEM) is proposed for simulating biomass fast pyrolysis reacting granular flows in a double auger reactor, in which particle hydrodynamics and interparticle heat transfer processes are involved and coupled with chemical reactions in solid particles. An adaptive time step algorithm is proposed to achieve a stable coupling between the integration of reaction ordinary differential equations and the DEM solver, and the algorithm is proven computationally efficient. A multi-component fast pyrolysis kinetics is adopted and its modeling accuracy is assessed by carrying out simulations of benchmark biomass pyrolysis experiments and comparing the prediction results with experimental data. The predicted product yields of bio-oil, char and non-condensable gas from the simulation of the biomass fast pyrolysis in the auger reactor are in satisfactory agreement with experimental measurements. The decomposition rates of biomass components in the reactor are revealed from the simulation and the pyrolysis number Py is calculated from the decomposition rate of biomass and the heat transfer coefficient. The Py number illustrates that the biomass fast pyrolysis process is limited by the heat transfer process at particle size of 2 mm. [less ▲]

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See detailDynamic facial expression generation on hilbert hypersphere with conditional wasserstein generative adversarial nets
Otberdout, Naima; Daoudi, Mohamed; Kacem, Anis UL et al

in IEEE Transactions on Pattern Analysis and Machine Intelligence (2020)

In this work, we propose a novel approach for generating videos of the six basic facial expressions given a neutral face image. We propose to exploit the face geometry by modeling the facial landmarks ... [more ▼]

In this work, we propose a novel approach for generating videos of the six basic facial expressions given a neutral face image. We propose to exploit the face geometry by modeling the facial landmarks motion as curves encoded as points on a hypersphere. By proposing a conditional version of manifold-valued Wasserstein generative adversarial network (GAN) for motion generation on the hypersphere, we learn the distribution of facial expression dynamics of different classes, from which we synthesize new facial expression motions. The resulting motions can be transformed to sequences of landmarks and then to images sequences by editing the texture information using another conditional Generative Adversarial Network. To the best of our knowledge, this is the first work that explores manifold-valued representations with GAN to address the problem of dynamic facial expression generation. We evaluate our proposed approach both quantitatively and qualitatively on two public datasets; Oulu-CASIA and MUG Facial Expression. Our experimental results demonstrate the effectiveness of our approach in generating realistic videos with continuous motion, realistic appearance and identity preservation. We also show the efficiency of our framework for dynamic facial expression generation, dynamic facial expression transfer and data augmentation for training improved emotion recognition models. [less ▲]

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See detailEditorial : Analyzing cross-border Labor Markets
Pigeron-Piroth, Isabelle UL; Belkacem, Rachid

in Borders in Perspective (2020), 3

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See detailSOCIOECONOMIC PROFILES OF CROSS-BORDER COMMUTERS AT THE FRENCH BORDERS: common features and territorial specificities
Pigeron-Piroth, Isabelle UL; Belkacem, Rachid

in Borders in Perspective (2020), 3

This study proposes to shed light on the main aspects of the socio-professional profiles of cross-border commuters at the various French borders. Nearly 385,000 cross-border commuters were living in ... [more ▼]

This study proposes to shed light on the main aspects of the socio-professional profiles of cross-border commuters at the various French borders. Nearly 385,000 cross-border commuters were living in France in 2013. The destination countries of these cross-border commuters are very diverse (mainly Switzerland and Luxembourg). There is a relative territorial specificity of the socio-professional profiles according to the different areas of employment. Cross-border work is a regulatory factor in the different cross-border labor markets, allowing for a quantitative but also qualitative adjustment between reserves and man-power needs. This analysis will thus provide a better understanding of cross-border mobility and, above all, identify their different socioeconomic functions with regard to the countries of destination. For this purpose, we have made use of the 2013 INSEE population census data. [less ▲]

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See detailCROSS-BORDER LABOR MARKETS: dynamics and perspectives
Pigeron-Piroth, Isabelle UL; Belkacem, Rachid

in Borders in Perspective (2020), 3

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See detailBIM-Based End-of-Lifecycle Decision Making and Digital Deconstruction: Literature Review
Akbarieh, Arghavan UL; Jayasinghe, Laddu Bhagya UL; Waldmann, Danièle UL et al

in Sustainability (2020), 12(7), 2670

This article is the second part of a two-part study, which explored the extent to which Building Information Modelling (BIM) is used for End-of-Lifecycle (EoL) scenario selection to minimise the ... [more ▼]

This article is the second part of a two-part study, which explored the extent to which Building Information Modelling (BIM) is used for End-of-Lifecycle (EoL) scenario selection to minimise the Construction and Demolition Waste (CDW). The conventional literature review presented here is based on the conceptual landscape that was obtained from the bibliometric and scientometric analysis in the first part of the study. Seven main academic research directions concerning the BIM-based EoL domain were found, including social and cultural factors, BIM-based Design for Deconstruction (DfD), BIM-based deconstruction, BIM-based EoL within LCA, BIM-aided waste management, Material and Component Banks (M/C Banks), off-site construction, interoperability and Industry Foundation Classes (IFC). The analysis highlights research gaps in the path of raw materials to reusable materials, i.e., from the deconstruction to M/C banks to DfD-based designs and then again to deconstruction. BIM-based EoL is suffering from a lack of a global framework. The existing solutions are based on local waste management policies and case-specific sustainability criteria selection. Another drawback of these ad hoc but well-developed BIM-based EoL prototypes is their use of specific proprietary BIM tools to support their framework. This disconnection between BIM tools and EoL tools is reportedly hindering the BIM-based EoL, while no IFC classes support the EoL phase information exchange. [less ▲]

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See detailEine Doktorarbeit zu beginnen, ist (relativ) leicht...
Schommer, Christoph UL

in Luxemburger Wort (2020)

Vor einigen Wochen war es wieder soweit: Zwei Doktorandinnen hatten ihre wissenschaftlichen Arbeiten eingereicht, sich den Fragen einer internationalen Expertenkommission gestellt, und schließlich ihre ... [more ▼]

Vor einigen Wochen war es wieder soweit: Zwei Doktorandinnen hatten ihre wissenschaftlichen Arbeiten eingereicht, sich den Fragen einer internationalen Expertenkommission gestellt, und schließlich ihre Doktorarbeiten verteidigt. [less ▲]

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See detailGrundlagen und Stellenwert der COMT- und MAO-B-Inhibitoren in der Therapie des idiopathischen Parkinson-Syndroms.
Woitalla, Dirk; Krüger, Rejko UL; Lorenzl, Stefan et al

in Fortschritte der Neurologie-Psychiatrie (2020)

Inhibitors of COMT and MAO-B are well established in the pharmacotherapy of Parkinson's disease (PD). MAO-B inhibitors are used as monotherapy as well as in combination with levodopa, whereas COMT ... [more ▼]

Inhibitors of COMT and MAO-B are well established in the pharmacotherapy of Parkinson's disease (PD). MAO-B inhibitors are used as monotherapy as well as in combination with levodopa, whereas COMT inhibitors exert their effects only in conjungtion with levodopa. Both classes of compounds prolong the response duration of levodopa and optimise its clinical benefit. As a result, the ON-times are prolonged significantly. In the past, MAO-B inhibitors were also adminstered for neuroprotection; however, despite convincing scientific reasoning in support of neuroprotective effects, these could not be substantiated in clinical studies performed so far. [less ▲]

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See detailCovid-19 : « And the world went digital… »
Sorlut, Pierre; Derian, Maxime UL

in D'Lëtzebuerger Land (2020)

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See detailTransboundary water diplomacy among small states: a giant dilemma for Central American regionalism
Koff, Harlan UL; Maganda, Carmen UL; Kauffer, Edith

in Water International (2020)

Water diplomacy aims to shift water disputes from zero-sum games into positive-sum cooperation models though actor-driven approaches. Small states are often viewed as facilitators of diplomacy through a ... [more ▼]

Water diplomacy aims to shift water disputes from zero-sum games into positive-sum cooperation models though actor-driven approaches. Small states are often viewed as facilitators of diplomacy through a commitment to regionalism and consensus, which highlights their influence in international affairs. Responding to the research question, ‘How do “non-decisions” lead to status quo in water diplomacy?’ this article discusses how regional water diplomacy based on influence is weakened by the domestic shortcomings of small states’ political systems, where authorities use non-decision-making to maintain a status quo that guarantees their legitimized power. [less ▲]

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See detailPuRSUE -from specification of robotic environments to synthesis of controllers
Bersani, Marcello M.; Soldo, Matteo; Menghi, Claudio UL et al

in Formal Aspects of Computing (2020)

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See detailGene family information facilitates variant interpretation and identification of disease-associated genes in neurodevelopmental disorders
Lal, Dennis; May, Patrick UL; Perez-Palma, Eduardo et al

in Genome Medicine (2020), 12(28),

Background: Classifying pathogenicity of missense variants represents a major challenge in clinical practice during the diagnoses of rare and genetic heterogeneous neurodevelopmental disorders (NDDs ... [more ▼]

Background: Classifying pathogenicity of missense variants represents a major challenge in clinical practice during the diagnoses of rare and genetic heterogeneous neurodevelopmental disorders (NDDs). While orthologous gene conservation is commonly employed in variant annotation, approximately 80% of known disease-associated genes belong to gene families. The use of gene family information for disease gene discovery and variant interpretation has not yet been investigated on genome-wide scale. We empirically evaluate whether paralog conserved or non-conserved sites in human gene families are important in NDDs. Methods: Gene family information was collected from Ensembl. Paralog conserved sites were defined based on paralog sequence alignments. 10,068 NDD patients and 2,078 controls were statistically evaluated for de novo variant burden in gene families. Results: We demonstrate that disease-associated missense variants are enriched at paralog conserved sites across all disease groups and inheritance models tested. We developed a gene family de novo enrichment framework that identified 43 exome-wide enriched gene families including 98 de novo variant carrying genes in NDD patients of which 28 represent novel candidate genes for NDD which are brain expressed and under evolutionary constraint. Conclusion: This study represents the first method to incorporate gene-family information into a statistical framework to interpret variant data for NDDs and to discover newly NDD -associated genes. [less ▲]

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