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See detailEnhancing children’s numerical skills through a play-based intervention at kindergarten and at home: a quasi-experimental study
de Chambrier, Anne-Françoise; Baye, Ariane; Tinnes-Vigne, Mélanie et al

in Early Childhood Research Quarterly (2021), 54

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See detailGenome-wide linkage analysis of families with primary hyperhidrosis
Schote, Andrea B.; Schiel, Florian; Schmitt, Benedict et al

in PLoS ONE (2020)

Primary focal hyperhidrosis (PFH, OMIM %144110) is a genetically influenced condition characterised by excessive sweating. Prevalence varies between 1.0–6.1% in the general population, dependent on ... [more ▼]

Primary focal hyperhidrosis (PFH, OMIM %144110) is a genetically influenced condition characterised by excessive sweating. Prevalence varies between 1.0–6.1% in the general population, dependent on ethnicity. The aetiology of PFH remains unclear but an autosomal dominant mode of inheritance, incomplete penetrance and variable phenotypes have been reported. In our study, nine pedigrees (50 affected, 53 non-affected individuals) were included. Clinical characterisation was performed at the German Hyperhidrosis Centre, Munich, by using physiological and psychological questionnaires. Genome-wide parametric linkage analysis with GeneHunter was performed based on the Illumina genome-wide SNP arrays. Haplotypes were constructed using easyLINKAGE and visualised via HaploPainter. Whole-exome sequencing (WES) with 100x coverage in 31 selected members (24 affected, 7 non-affected) from our pedigrees was achieved by next generation sequencing. We identified four genome-wide significant loci, 1q41-1q42.3, 2p14-2p13.3, 2q21.2-2q23.3 and 15q26.3-15q26.3 for PFH. Three pedigrees map to a shared locus at 2q21.2-2q23.3, with a genome-wide significant LOD score of 3.45. The chromosomal region identified here overlaps with a locus at chromosome 2q22.1-2q31.1 reported previously. Three families support 1q41-1q42.3 (LOD = 3.69), two families share a region identical by descent at 2p14-2p13.3 (LOD = 3.15) and another two families at 15q26.3 (LOD = 3.01). Thus, our results point to considerable genetic heterogeneity. WES did not reveal any causative variants, suggesting that variants or mutations located outside the coding regions might be involved in the molecular pathogenesis of PFH. We suggest a strategy based on whole-genome or targeted next generation sequencing to identify causative genes or variants for PFH. [less ▲]

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See detailMetaheuristics for the Online Printing Shop Scheduling Problem
Tessaro Lunardi, Willian UL; Birgin, Ernesto G.; Ronconi, Débora P. et al

in European Journal of Operational Research (2020)

In this work, the online printing shop scheduling problem introduced in (Lunardi et al., Mixed Integer Linear Programming and Constraint Programming Models for the Online Printing Shop Scheduling Problem ... [more ▼]

In this work, the online printing shop scheduling problem introduced in (Lunardi et al., Mixed Integer Linear Programming and Constraint Programming Models for the Online Printing Shop Scheduling Problem, Computers & Operations Research, to appear) is considered. This challenging real scheduling problem, that emerged in the nowadays printing industry, corresponds to a flexible job shop scheduling problem with sequencing flexibility; and it presents several complicating specificities such as resumable operations, periods of unavailability of the machines, sequence-dependent setup times, partial overlapping between operations with precedence constraints, and fixed operations, among others. A local search strategy and metaheuristic approaches for the problem are proposed and evaluated. Based on a common representation scheme, trajectory and populational metaheuristics are considered. Extensive numerical experiments with large-sized instances show that the proposed methods are suitable for solving practical instances of the problem; and that they outperform a half-heuristic-half-exact off-the-shelf solver by a large extent. Numerical experiments with classical instances of the flexible job shop scheduling problem show that the introduced methods are also competitive when applied to this particular case. [less ▲]

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See detailA Remote Carrier Synchronization Technique for Coherent Distributed Remote Sensing Systems
Merlano Duncan, Juan Carlos UL; Martinez Marrero, Liz UL; Querol, Jorge UL et al

in IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing (2020)

Phase, frequency, and time synchronization are crucial requirements for many applications, such as multi-static remote sensing and communication systems. Moreover, the synchronization solution becomes ... [more ▼]

Phase, frequency, and time synchronization are crucial requirements for many applications, such as multi-static remote sensing and communication systems. Moreover, the synchronization solution becomes even more challenging when the nodes are orbiting or flying on airborne or spaceborne platforms. This paper compares the available technologies used for the synchronization and coordination of nodes in distributed remote sensing applications. Additionally, this paper proposes a general system model and identifies preliminary guidelines and critical elements for implementing the synchronization mechanisms exploiting the inter-satellite communication link. The distributed phase synchronization loop introduced in this work deals with the self-interference in a full-duplex point to point scenario by transmitting two carriers at each node. All carriers appear with different frequency offsets around a central frequency, called the application central-frequency or the beamforming frequency. This work includes a detailed analysis of the proposed algorithm and the required simulations to verify its performance for different phase noise, AWGN, and Doppler shift scenarios. [less ▲]

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See detailA Narrative Review of Motor Competence in Children and Adolescents: What We Know and What We Need to Find Out
Lopes, Luis; Santos, Rute; Coelho e Silva, Manuel et al

in International Journal of Environmental Research and Public Health (2020), 18(1), 1-20

Lack of physical activity is a global public health problem causing not only morbidity and premature mortality, but it is also a major economic burden worldwide. One of the cornerstones of a physically ... [more ▼]

Lack of physical activity is a global public health problem causing not only morbidity and premature mortality, but it is also a major economic burden worldwide. One of the cornerstones of a physically active lifestyle is Motor Competence (MC). MC is a complex biocultural attribute and therefore, its study requires a multi-sectoral, multi-, inter- and transdisciplinary approach. MC is a growing area of research, especially in children and adolescents due to its positive association with a plethora of health and developmental outcomes. Many questions, however, remain to be answered in this field of research, with regard to: (i) Health and Developmental-related Associations of MC; (ii) Assessment of MC; (iii) Prevalence and Trends of MC; (iv) Correlates and Determinants of MC; (v) MC Interventions, and (vi) Translating MC Research into Practice and Policy. This paper presents a narrative review of the literature, summarizing current knowledge, identifying key research gaps and presenting questions for future investigation on MC in children and adolescents. This is a collaborative effort from the International Motor Competence Network (IMCNetwork) a network of academics and researchers aiming to promote international collaborative research and knowledge translation in the expansive field of MC. The knowledge and deliverables generated by addressing and answering the aforementioned research questions on MC presented in this review have the potential to shape the ways in which researchers and practitioners promote MC and physical activity in children and adolescents across the world. [less ▲]

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See detailA Case Driven Study of the Use of Time Series Classification for Flexibility in Industry 4.0
Polge, Julien UL; Robert, Jérémy UL; Le Traon, Yves UL

in Sensors (2020), 20(24),

With the Industry 4.0 paradigm comes the convergence of the Internet Technologies and Operational Technologies, and concepts, such as Industrial Internet of Things (IIoT), cloud manufacturing, Cyber ... [more ▼]

With the Industry 4.0 paradigm comes the convergence of the Internet Technologies and Operational Technologies, and concepts, such as Industrial Internet of Things (IIoT), cloud manufacturing, Cyber-Physical Systems (CPS), and so on. These concepts bring industries into the big data era and allow for them to have access to potentially useful information in order to optimise the Overall Equipment Effectiveness (OEE); however, most European industries still rely on the Computer-Integrated Manufacturing (CIM) model, where the production systems run as independent systems (i.e., without any communication with the upper levels). Those production systems are controlled by a Programmable Logic Controller, in which a static and rigid program is implemented. This program is static and rigid in a sense that the programmed routines cannot evolve over the time unless a human modifies it. However, to go further in terms of flexibility, we are convinced that it requires moving away from the aforementioned old-fashioned and rigid automation to a ML-based automation, i.e., where the control itself is based on the decisions that were taken by ML algorithms. In order to verify this, we applied a time series classification method on a scale model of a factory using real industrial controllers, and widened the variety of parts the production line has to treat. This study shows that satisfactory results can be obtained only at the expense of the human expertise (i.e., in the industrial process and in the ML process). [less ▲]

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See detailA Survey of Information Entropy Metrics for Complex Networks
Omar, Yamila UL; Plapper, Peter UL

in Entropy (2020)

Information entropy metrics have been applied to a wide range of problems that were abstracted as complex networks. This growing body of research is scattered in multiple disciplines, which makes it ... [more ▼]

Information entropy metrics have been applied to a wide range of problems that were abstracted as complex networks. This growing body of research is scattered in multiple disciplines, which makes it difficult to identify available metrics and understand the context in which they are applicable. In this work, a narrative literature review of information entropy metrics for complex networks is conducted following the PRISMA guidelines. Existing entropy metrics are classified according to three different criteria: whether the metric provides a property of the graph or a graph component (such as the nodes), the chosen probability distribution, and the types of complex networks to which the metrics are applicable. Consequently, this work identifies the areas in need for further development aiming to guide future research efforts. [less ▲]

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See detailFormation of ultra-thin Ge1−xSnx/Ge1−x−ySixSny quantum heterostructures and their electrical properties for realizing resonant tunneling diode
Suwito, Galih Ramadana; Fukuda, Masahiro; Suprayoga, Edi et al

in Applied Physics Letters (2020), 117(23), 232104

Huge thermal noise owing to the narrow energy bandgap is one of the critical issues for group IV-based photonics in the mid-infrared regime. With this motivation, we examined to form Ge1−xSnx ... [more ▼]

Huge thermal noise owing to the narrow energy bandgap is one of the critical issues for group IV-based photonics in the mid-infrared regime. With this motivation, we examined to form Ge1−xSnx/Ge1−x−ySixSny quantum heterostructures (QHs) by molecular beam epitaxy for realizing resonant tunneling diodes composed of group-IV materials. We confirmed the formation of approximately 2 nm-thick Ge1−xSnx/Ge1−x−ySixSny QHs with atomically flat interfaces by x-ray diffraction and transmission electron microscopy methods. Moreover, by the current density–voltage (J–V) measurement at 10 K, we observed the occurrence of a non-linear distinct hump in the J–V characteristic, which is possibly originated from quantum transport of heavy holes. According to the tunneling transmission spectra simulation result, the hump property would be due to two possible scenarios: a resonant tunneling of heavy holes in the QH and/or a resonance phenomenon that heavy holes pass just above a potential barrier. [less ▲]

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See detailNotes on the ECHR and the Disunited Kingdom 'After' Brexit - In Memoriam Scott Crosby
Robinson, Gavin UL

in New Journal of European Criminal Law (2020)

When the idea of this special edition occurred to the team behind the New Journal of European Criminal Law, my first thought was to go back through all of Scott Crosby’s contributions in print as editor ... [more ▼]

When the idea of this special edition occurred to the team behind the New Journal of European Criminal Law, my first thought was to go back through all of Scott Crosby’s contributions in print as editor-in-chief and see whether a mini-retrospective on the themes and views therein would be worthy of inclusion here – by Scott’s own standards. These notes focus on what gradually became the single biggest concern expressed in Scott’s editorials: the perilous position of the European Convention on Human Rights (ECHR) in a post-Brexit UK – in concreto, the prospect of what he labelled ‘Brexit plus’: a British exit from the ECHR system. I begin with Scott’s views on the European Union (EU) Referendum and the Brexit process. Next comes the great uncertainty currently surrounding the future of Convention rights in the United Kingdom, set against the emphasis placed by the editorials on the instrumental role of the ECHR in fostering peace across the whole of Europe, within and beyond the territory of the EU. In the event that Brexit plus should materialise, writing in the wake of polls showing all-time record support in Scotland for secession from the United Kingdom I close by asking whether Scotland might be able to ‘leave a light on for Strasbourg’. [less ▲]

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See detailCan You Trust Your Number Sense: Distinct Processing of Numbers and Quantities in Elementary School Children
Marinova, Mila UL; Reynvoet, Bert

in Journal of Numerical Cognition (2020), 6(3), 304-321

Theories of number development have traditionally argued that the acquisition and discrimination of symbolic numbers (i.e., number words and digits) are grounded in and are continuously supported by the ... [more ▼]

Theories of number development have traditionally argued that the acquisition and discrimination of symbolic numbers (i.e., number words and digits) are grounded in and are continuously supported by the Approximate Number System (ANS)—an evolutionarily ancient system for number. In the current study, we challenge this claim by investigating whether the ANS continues to support the symbolic number processing throughout development. To this end, we tested 87 first- (Age M = 6.54 years, SD = 0.58), third- (Age M = 8.55 years, SD = 0.60) and fifth-graders (Age M = 10.63 years, SD = 0.67) on four audio-visual comparison tasks (1) Number words–Digits, (2) Tones–Dots,(3) Number words–Dots, (4) Tones–Digits, while varying the Number Range (Small and Large), and the Numerical Ratio (Easy, Medium,and Hard). Results showed that larger and faster developmental growth in the performance was observed in the Number Words–Digits task, while the tasks containing at least one non-symbolic quantity showed smaller and slower developmental change. In addition, the Ratio effect (i.e., the signature of ANS being addressed) was present in the Tones–Dots, Tones–Digits, and Number Words–Dots tasks, but was absent in the Number Words–Digits task. These findings suggest that it is unlikely that the ANS continuously underlines the acquisition and the discrimination of the symbolic numbers. Rather, our results indicate that non-symbolic quantities and symbolic numbers follow qualitatively distinct developmental paths, and argue that the latter ones are processed in a semantic network which starts to emerge from an early age. [less ▲]

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See detailFootball activism as political contention: Contextual determinants of membership in the association of supporters of Hajduk Split
Glaurdic, Josip UL

in International Review for the Sociology of Sport (2020), 55(8), 1094-1115

Where do politically activist football supporters come from? What are the social conditions under which they are successfully recruited and mobilised? This article answers those questions by analysing a ... [more ▼]

Where do politically activist football supporters come from? What are the social conditions under which they are successfully recruited and mobilised? This article answers those questions by analysing a unique dataset of more than 43,000 members of Our Hajduk – the association of supporters of the Croatian club Hajduk Split – as well as a host of data on the communities they live in. The analysis shows that Our Hajduk thrives in exactly the same areas where most other social, civil and political organisations thrive: among the more educated and more socioeconomically successful. Most importantly, the analysis shows that the pattern of Our Hajduk membership closely follows the patterns of political affiliation and participation in Croatia’s electoral arena and is guided by the opposition to political players who have dominated Croatian football and turned it into a social field marked by corruption and mismanagement. [less ▲]

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See detailFrom Print to Digital, from Document to Data: Digitalisation at the Publications Office of the European Union
Schafer, Valerie UL

in Open Information Science (2020), (4), 204-217

Since the 1970s, the Publications Office of the European Union, the official publisher of all the institutions and bodies of the EU, has had to adapt to a fast-changing situation as the number of EU ... [more ▼]

Since the 1970s, the Publications Office of the European Union, the official publisher of all the institutions and bodies of the EU, has had to adapt to a fast-changing situation as the number of EU Member States has grown and the number and nature of publications has evolved (including publishing public tenders of EU institutions and Member States in 1978 through a supplement to the Official Journal of the European Union and handling CELEX, an interinstitutional and multilingual automated documentation system for community law, in 1992). These changes occurred over several ages of computing. The computerisation of the Publications Office was primarily a response to the need for rationalisation and productivity, but the aim was also to gradually adapt to new types of document publication and consultation. These different stages of digitalisation required the constant transfer of information to a multitude of media. Supports, such as punched cards, optical discs and CD-ROMs, had varying life expectancies and are all evidence of attempts to digitise information before the Web. This evolution not only illustrates the need to constantly harmonise a large amount of information, it also highlights some continuities. It affects the management of information systems but also meets regularly updated standardisation, interoperability and sustainability needs within a complex ecosystem. [less ▲]

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See detailChanges in school alienation profiles among secondary school students and the role of teaching style: Results from a longitudinal study in Luxembourg and Switzerland
Hadjar, Andreas UL; Grecu, Alyssa; Scharf, Jan et al

in International Journal of Educational Research (2020), early online

What students think about school has a major impact on learning and academic achievement. The multi-domain concept of school alienation distinguishes between alienation from learning, from teachers and ... [more ▼]

What students think about school has a major impact on learning and academic achievement. The multi-domain concept of school alienation distinguishes between alienation from learning, from teachers and from classmates. We aim to study a) alienation patterns among secondary school students, b) how school alienation profiles change from year 7 to year 9 and how secondary school students transition between profiles, and c) the role of teaching style for transitions between school alienation profiles. We draw on panel data of secondary school students from Luxembourg and Switzerland. Results of latent profile/latent transition analyses reveal distinct school alienation profiles, country differences and support for the idea that student-oriented, supportive teaching styles might prevent students from transitioning towards more-highly alienated profiles. [less ▲]

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See detailDouble-Graded Quantum Superplane
Bruce, Andrew UL; Duplij, Steven

in Reports on Mathematical Physics (2020), 86(3), 383-400

A ℤ2 × ℤ2-graded generalisation of the quantum superplane is proposed and studied. We construct a bicovariant calculus on what we shall refer to as the double-graded quantum superplane. The ommutation ... [more ▼]

A ℤ2 × ℤ2-graded generalisation of the quantum superplane is proposed and studied. We construct a bicovariant calculus on what we shall refer to as the double-graded quantum superplane. The ommutation rules between the coordinates, their differentials and partial derivatives are explicitly given. Furthermore, we show that an extended version of the double-graded quantum superplane admits a natural Hopf -algebra structure. [less ▲]

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See detailA comparison of constitutive models for describing the flow of uncured styrene-butadiene rubber
Řehoř, Martin; Gansen, Alex UL; Sill, Clemens et al

in Journal of Non-Newtonian Fluid Mechanics (2020), 286

Uncured styrene-butadiene rubber (SBR) can be modelled as a viscoelastic material with at least two different relaxation mechanisms. In this paper we compare multi-mode constitutive models combining two ... [more ▼]

Uncured styrene-butadiene rubber (SBR) can be modelled as a viscoelastic material with at least two different relaxation mechanisms. In this paper we compare multi-mode constitutive models combining two viscoelastic modes (linear and/or nonlinear) in three possible ways. Our particular choice of the two modes was inspired by models originally developed to describe the response of asphalt binders. We select the model that best fits the experimental data obtained from a modified stress relaxation experiment in the torsional configuration of the plate-plate rheometer. The optimisation of the five model parameters for each model is achieved by minimising the weighted least-squares distance between experimental observations and the computer model output using a tree-structured Parzen estimator algorithm to find an initial guess, followed by further optimisation using the Nelder-Mead simplex algorithm. The results show that the model combining the linear mode and the nonlinear mode is the most suitable variant to describe the observed behavior of SBR in the given regime. The predictive capabilities of the three models are further examined in changed experimental and numerical configurations. Full data and code to produce the figures in this article are included as supplementary material. [less ▲]

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See detailConstant Envelope MIMO-OFDM Precoding for Low Complexity Large-Scale Antenna Array Systems
Domouchtsidis, Stavros UL; Tsinos, Christos UL; Chatzinotas, Symeon UL et al

in IEEE Transactions on Wireless Communications (2020)

Herein, we consider constant envelope precoding in a multiple-input multiple-output orthogonal frequency division multiplexing system (CE MIMO-OFDM) for frequency selective channels. In CE precoding the ... [more ▼]

Herein, we consider constant envelope precoding in a multiple-input multiple-output orthogonal frequency division multiplexing system (CE MIMO-OFDM) for frequency selective channels. In CE precoding the signals for each transmit antenna are designed to have constant amplitude regardless of the channel realization and the information symbols that must be conveyed to the users. This facilitates the use of power-efficient components, such as phase shifters (PS) and nonlinear power amplifiers, which are key for the feasibility of large-scale antenna array systems because of their low cost and power consumption. The CE precoding problem is firstly formulated as a least-squares problem with a unit modulus constraint and solved using an algorithm based on coordinate descent. The large number of optimization variables in the case of the MIMO-OFDM system motivates the search for a more computationally efficient solution. To tackle this, we reformulate the CE precoding design into an unconstrained nonlinear least-squares problem, which is solved efficiently using the Gauss-Newton algorithm. Simulation results underline the efficiency of the proposed solutions and show that they outperform state of the art techniques. [less ▲]

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See detailSimultaneous Diagonalization of Incomplete Matrices and Applications
Coron, Jean-Sébastien UL; Notarnicola, Luca UL; Wiese, Gabor UL

in Proceedings of the Fourteenth Algorithmic Number Theory Symposium (ANTS-XIV), edited by Steven Galbraith, Open Book Series 4, Mathematical Sciences Publishers, Berkeley, 2020 (2020), 4

We consider the problem of recovering the entries of diagonal matrices {U_a}_a for a = 1, . . . , t from multiple “incomplete” samples {W_a}_a of the form W_a = P U_a Q, where P and Q are unknown matrices ... [more ▼]

We consider the problem of recovering the entries of diagonal matrices {U_a}_a for a = 1, . . . , t from multiple “incomplete” samples {W_a}_a of the form W_a = P U_a Q, where P and Q are unknown matrices of low rank. We devise practical algorithms for this problem depending on the ranks of P and Q. This problem finds its motivation in cryptanalysis: we show how to significantly improve previous algorithms for solving the approximate common divisor problem and breaking CLT13 cryptographic multilinear maps. [less ▲]

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See detailNOMA-Enabled Multi-Beam Satellite Systems: Joint Optimization to Overcome Offered-Requested Data Mismatches
Wang, Anyue UL; Lei, Lei UL; Lagunas, Eva UL et al

in IEEE Transactions on Vehicle Technology (2020)

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See detailThe Dissolution of the Austro-Hungarian Monarchy: Border Making and its Consequences.
Venken, Machteld UL

in European Review of History (2020), 26(6), 697-708

This special issue addresses practices of border-making and their consequences on the territory of the former Austro-Hungarian Monarchy. As the reality did not correspond to the peaceful Europe ... [more ▼]

This special issue addresses practices of border-making and their consequences on the territory of the former Austro-Hungarian Monarchy. As the reality did not correspond to the peaceful Europe articulated in the Paris Treaties, a multitude of (un)foreseen complications followed the drawing of borders and states. Articles include new case studies on the creation, centralization or peripheralization of border regions, such as Subcarpathian Rus, Vojvodina, Banat and the Carpathian Mountains, on border zones such as the Czechoslovakian harbour in Germany, and on cross-border activities. The special issue shows how disputes over national identities and ethnic minorities, as well as other factors such as the economic consequences of the new state borders, appeared on the interwar political agenda and coloured the lives of borderland inhabitants. Adopting a bottom-up approach, the contributions demonstrate the agency of borderlands and their people in the establishment, functioning, disorganization or ultimate breakdown of some of the newly created interwar nation-states. [less ▲]

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See detailImpact of Varying Radio Power Density on Wireless Communications of RF Energy Harvesting Systems
Luo, Yu; Pu, Lina; Lei, Lei UL

in IEEETransactions on Communications (2020)

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See detailOpinion Statement ECJ-TF 2/2020 on the ECJ Decision of 3 March 2020 in Vodafone Magyarország Mobil Távközlési Zrt. (Case C-75/18) on Progressive Turnover Taxes
García Prats, Alfredo; Haslehner, Werner UL; Heydt, Volker et al

in European Taxation (2020), 60(12), 555-564

This CFE Opinion Statement discusses the decision of the Grand Chamber of the ECJ in Vodafone. The Court held that the imposition of the Hungarian progressive turnover-based tax on the telecommunications ... [more ▼]

This CFE Opinion Statement discusses the decision of the Grand Chamber of the ECJ in Vodafone. The Court held that the imposition of the Hungarian progressive turnover-based tax on the telecommunications sector did not infringe the EU fundamental freedoms or article 401 of the VAT Directive (2006/112), and that the question regarding the prohibition of State aid was inadmissible. Vodafone is especially important in respect of the current debate regarding turnover-based digital services taxes. [less ▲]

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See detailMultiple Vulnerabilities: The Effects of Neighborhood Structural Changes upon Older Residents’ Mental Health and Perceptions of the Broader Community
Settels, Jason UL

in Journal of Community Psychology (2020)

Neighborhoods' structural conditions are consequential for their social circumstances and residents' well‐being. Neighborhood effects might be accentuated among older residents because their daily ... [more ▼]

Neighborhoods' structural conditions are consequential for their social circumstances and residents' well‐being. Neighborhood effects might be accentuated among older residents because their daily activities and social lives are more confined to their immediate communities. This study examines how changing neighborhood socioeconomic disadvantage affects older residents' depression and stress, as well as perceptions of neighborhood context. This study employed waves 2 (2010–2011) and 3 (2015–2016) of the National Social Life, Health, and Aging Project survey (N= 2357) and fixed‐effects linear regression models to study these relationships. While rising neighborhood socioeconomic disadvantage was associated with more depression and stress, it was negatively associated with overall neighborhood social capital and neighborhood social cohesion, and was only associated with lower perceptions of neighborhood safety among respondents who relocated to new neighborhoods. Beyond cross‐sectional associations, changing neighborhood socioeconomic disadvantage is associated with changes in mental health and perceptions of neighborhood social context. [less ▲]

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See detailJoint User Grouping, Scheduling, and Precoding for Multicast Energy Efficiency in Multigroup Multicast Systems
Bandi, Ashok UL; Mysore Rama Rao, Bhavani Shankar UL; Chatzinotas, Symeon UL et al

in IEEE Transactions on Wireless Communications (2020)

This paper studies the joint design of user grouping, scheduling (or admission control) and precoding to optimize energy efficiency (EE) for multigroup multicast scenarios in single-cell multiuser MISO ... [more ▼]

This paper studies the joint design of user grouping, scheduling (or admission control) and precoding to optimize energy efficiency (EE) for multigroup multicast scenarios in single-cell multiuser MISO downlink channels. Noticing that the existing definition of EE fails to account for group sizes, a new metric called multicast energy efficiency (MEE) is proposed. In this context, the joint design is considered for the maximization of MEE, EE, and scheduled users. Firstly, with the help of binary variables (associated with grouping and scheduling) the joint design problem is formulated as a mixed-Boolean fractional programming problem such that it facilitates the joint update of grouping, scheduling and precoding variables. Further, several novel optimization formulations are proposed to reveal the hidden difference of convex/ concave structure in the objective and associated constraints. Thereafter, we propose a convex-concave procedure framework based iterative algorithm for each optimization criteria where grouping, scheduling, and precoding variables are updated jointly in each iteration. Finally, we compare the performance of the three design criteria concerning three performance metrics namely MEE, EE, and scheduled users through Monte-Carlo simulations. These simulations establish the need for MEE and the improvement from the system optimization. [less ▲]

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See detailManaging residence permits and unemployment of third-country nationals during the COVID-19 crisis in the EU
Sommarribas, Adolfo UL

in Journaal Vreemdelingenrecht (2020), 19(4), 14-21

This article will try to provide a state of play of the response of the EU Member States to the COVID-19 crisis in regard to third-country nationals through the information compiled by the European ... [more ▼]

This article will try to provide a state of play of the response of the EU Member States to the COVID-19 crisis in regard to third-country nationals through the information compiled by the European Migration Network between 3 February until 15 June 2020. It will draw a state of play of the actions taken by Member States to confront the spread of the coronavirus in the immigration context. It also will focus on the validity of residence permits and the dispositions taken to avoid that legal migrants fall in an irregular situation and the effects of unemployment in regard to their residence permits. However, the article will not draw a timeline on when the actions were taken. [less ▲]

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See detailState Aggregation for Multiagent Communication over Rate-Limited Channels
Mostaani, Arsham UL; Vu, Thang Xuan UL; Chatzinotas, Symeon UL et al

in IEEE Global Communications Conference (2020)

A collaborative task is assigned to a multiagent system (MAS) in which agents are allowed to communicate. The MAS runs over an underlying Markov decision process and its task is to maximize the averaged ... [more ▼]

A collaborative task is assigned to a multiagent system (MAS) in which agents are allowed to communicate. The MAS runs over an underlying Markov decision process and its task is to maximize the averaged sum of discounted one-stage rewards. Although knowing the global state of the environment is necessary for the optimal action selection of the MAS, agents are limited to individual observations. The inter-agent communication can tackle the issue of local observability, however, the limited rate of the inter-agent communication prevents the agent from acquiring the precise global state information. To overcome this challenge, agents need to communicate their observations in a compact way such that the MAS compromises the minimum possible sum of rewards. We show that this problem is equivalent to a form of rate-distortion problem which we call the task-based information compression. State Aggregation for Information Compression (SAIC) is introduced here to perform the task-based information compression. The SAIC is shown, conditionally, to be capable of achieving the optimal performance in terms of the attained sum of discounted rewards. The proposed algorithm is applied to a rendezvous problem and its performance is compared with two benchmarks; (i) conventional source coding algorithms and the (ii) centralized multiagent control using reinforcement learning. Numerical experiments confirm the superiority and fast convergence of the proposed SAIC. [less ▲]

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See detailGeneralized Multiplexed Waveform Design Framework for Cost-Optimized MIMO Radar
Hammes, C.; R., B. S. M.; Ottersten, Björn UL

in IEEE Transactions on Signal Processing (2020), 69

Cost-optimization through the minimization of hardware and processing costs with minimal loss in performance is an interesting design paradigm in evolving and emerging Multiple-Input-Multiple-Output (MIMO ... [more ▼]

Cost-optimization through the minimization of hardware and processing costs with minimal loss in performance is an interesting design paradigm in evolving and emerging Multiple-Input-Multiple-Output (MIMO) radar systems. This optimization is a challenging task due to the increasing Radio Frequency (RF) hardware complexity as well as the signal design algorithm complexity in applications requiring high angular resolution. Towards addressing these, the paper proposes a low-complexity signal design framework, which incorporates a generalized time multiplex scheme for reducing the RF hardware complexity with a subsequent discrete phase modulation. The scheme further aims at achieving simultaneous transmit beamforming and maximum virtual MIMO aperture to enable better target detection and discrimination performance. Furthermore, the paper proposes a low-complexity signal design scheme for beampattern matching in the aforementioned setting. The conducted performance evaluation indicates that the listed design objectives are met. [less ▲]

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See detailAnalysis and visualisation of tremor dynamics in deep brain stimulation patients
Bremm, René Peter UL; Koch, Klaus Peter; Krüger, Rejko UL et al

in Current Directions in Biomedical Engineering (2020), 6(3), 4

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See detailA rule-based expert system for real-time feedback-control in deep brain stimulation
Bremm, René Peter UL; Koch, Klaus Peter; Krüger, Rejko UL et al

in Current Directions in Biomedical Engineering (2020), 6(3), 4

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See detailCommon diseases alter the physiological age-related blood microRNA profile.
Fehlmann, Tobias; Lehallier, Benoit; Schaum, Nicholas et al

in Nature communications (2020), 11(1), 5958

Aging is a key risk factor for chronic diseases of the elderly. MicroRNAs regulate post-transcriptional gene silencing through base-pair binding on their target mRNAs. We identified nonlinear changes in ... [more ▼]

Aging is a key risk factor for chronic diseases of the elderly. MicroRNAs regulate post-transcriptional gene silencing through base-pair binding on their target mRNAs. We identified nonlinear changes in age-related microRNAs by analyzing whole blood from 1334 healthy individuals. We observed a larger influence of the age as compared to the sex and provide evidence for a shift to the 5' mature form of miRNAs in healthy aging. The addition of 3059 diseased patients uncovered pan-disease and disease-specific alterations in aging profiles. Disease biomarker sets for all diseases were different between young and old patients. Computational deconvolution of whole-blood miRNAs into blood cell types suggests that cell intrinsic gene expression changes may impart greater significance than cell abundance changes to the whole blood miRNA profile. Altogether, these data provide a foundation for understanding the relationship between healthy aging and disease, and for the development of age-specific disease biomarkers. [less ▲]

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See detailPerpetuating Crises at the Source?: (Inter)Regionalism and Normative Incoherence for Sustainable Migration in Africa
Koff, Harlan UL

in Politikon: South African Journal of Political Studiesjavascript:$('next-but').click(); (2020), 47(4), 1-22

In response to the 2015–2016 migration crisis, the European Union established the Emergency Trust Fund for Africa that aimed ‘to address the root causes of instability, forced displacement and irregular ... [more ▼]

In response to the 2015–2016 migration crisis, the European Union established the Emergency Trust Fund for Africa that aimed ‘to address the root causes of instability, forced displacement and irregular migration and to contribute to better migration management.’ This article questions the logic of this approach to migration management by asking whether African regions can ‘better manage migration.’ The article examines the normative bases of migration policies amongst the African Union (AU) and six regional economic communities (RECs), as well as the normative bases of the development strategies pursued by the AU and these RECs. The article proposes normative policy coherence for development as an approach to better understand the relationships between regional integration, sustainable development and migration management in Africa. [less ▲]

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See detailMRV of Emissions and Mitigation Action: the Paris Agreement and Financial Support for Transparency- Related Capacity Building in Developing Countries
Alexandraki, Chrysa UL

in Climate Law (2020), 10(3-4), 308-334

This article examines the role of the Paris Agreement in enabling developed-country financial contributions aimed at building transparency-related capacity in developing countries. It first analyses the ... [more ▼]

This article examines the role of the Paris Agreement in enabling developed-country financial contributions aimed at building transparency-related capacity in developing countries. It first analyses the legal means and institutional arrangements utilized by the Agreement to support developing countries in building transparency-related capacity. It then argues that even though the Agreement adopts certain legal and institutional means to foster transparency-related capacity building in developing countries through financial support, it does so in a way that risks undermining the meaningful and accountable use of climate finance, while softening the bindingness of the Agreement’s provisions. The lack of accountability obligations on climate finance for developing countries, the principle of flexibility, and the challenges intrinsic to climate finance, combine to weaken the climate-finance obligation, while calling into question the effectiveness of the Agreement. [less ▲]

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See detailEffects of Emotional Music on Facial Emotion Recognition in Children with Autism Spectrum Disorder (ASD)
Wagener, Gary; Berning, Madeleine; Pinto Coelho da Costa, Andreia UL et al

in Journal of Autism and Developmental Disorders (2020)

Impaired facial emotion recognition in children with Autism Spectrum Disorder (ASD) is in contrast to their intact emotional music recognition. This study tested whether emotion congruent music enhances ... [more ▼]

Impaired facial emotion recognition in children with Autism Spectrum Disorder (ASD) is in contrast to their intact emotional music recognition. This study tested whether emotion congruent music enhances facial emotion recognition. Accuracy and reaction times were assessed for 19 children with ASD and 31 controls in a recognition task with angry, happy, or sad faces. Stimuli were shown with either emotionally congruent or incongruent music or no music. Although children with ASD had higher reaction times than controls, accuracy only differed when incongruent or no music was played, indicating that congruent emotional music can boost facial emotion recognition in children with ASD. Emotion congruent music may support emotion recognition in children with ASD, and thus may improve their social skills. [less ▲]

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See detailTransfer Learning and Meta Learning Based Fast Downlink Beamforming Adaptation
Yuan, Yi; Zheng, G.; Wong, K.-K. et al

in IEEE Transactions on Wireless Communications (2020)

This paper studies fast adaptive beamforming optimization for the signal-to-interference-plus-noise ratio balancing problem in a multiuser multiple-input single-output downlink system. Existing deep ... [more ▼]

This paper studies fast adaptive beamforming optimization for the signal-to-interference-plus-noise ratio balancing problem in a multiuser multiple-input single-output downlink system. Existing deep learning based approaches to predict beamforming rely on the assumption that the training and testing channels follow the same distribution which may not hold in practice. As a result, a trained model may lead to performance deterioration when the testing network environment changes. To deal with this task mismatch issue, we propose two offline adaptive algorithms based on deep transfer learning and meta-learning, which are able to achieve fast adaptation with the limited new labelled data when the testing wireless environment changes. Furthermore, we propose an online algorithm to enhance the adaptation capability of the offline meta algorithm in realistic non-stationary environments. Simulation results demonstrate that the proposed adaptive algorithms achieve much better performance than the direct deep learning algorithm without adaptation in new environments. The meta-learning algorithm outperforms the deep transfer learning algorithm and achieves near optimal performance. In addition, compared to the offline meta-learning algorithm, the proposed online meta-learning algorithm shows superior adaption performance in changing environments. [less ▲]

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See detailPeers als Quelle aktueller Motivation? Wie Jugendliche mit heterogenen Verhaltensweisen Peerinteraktionen in Abhängigkeit des behavioralen Klassenumfeldes erleben
Knickenberg, Margarita; Zurbriggen, Carmen UL; Schmidt, Philipp

in Zeitschrift für Pädagogische Psychologie (2020)

The relevance of peers for adolescents' development has already been confirmed in various studies. Among other things, adolescents indicated higher situational motivation and joy as well as less feelings ... [more ▼]

The relevance of peers for adolescents' development has already been confirmed in various studies. Among other things, adolescents indicated higher situational motivation and joy as well as less feelings of stress during social interactions with classmates compared to indi- vidual work settings. However, it turned out that adolescents with behavioural problems have difficulties in making and maintaining social contacts and friendships. While in previous studies behaviour was investigated as dichotomous variable, this study chose a dimensional, person-centered approach to identify adolescents with heterogeneous behaviour. Therefore, this paper aims at analysing effects of social inter- actions at school on emotional experiences of adolescents with heterogeneous behavioural profiles. In addition, a potential moderating effect of the classroom environment regarding behaviour will be tested. The sample comprised N = 719 students of grade five and six. Data were collected using the experience sampling method. In detail, the students completed a short questionnaire concerning their momentary emo- tional experience and their social context two to three times a day on five consecutive days at school. Thus, 8870 snapshots of the adolescents' emotional experiences and situations in class were available. Using teacher ratings regarding the students' behaviour, latent profile analyses were calculated and three different profiles within the sample were identified: students with adaptive, with internalising and with externalising behaviour. Findings of multilevel structural equation models show, first, that students are more motivated and less stressed while interacting with others during lessons (e.g. in partner or group activities) compared to individual working situations. This effect is more pronounced for students with internalising and externalising behavioural profiles. Second, the small differential moderating, but not significant effects indi- cate that the relation between adolescents' emotional experiences and peer interactions is not moderated by the classroom environment regarding prosocial or problem behaviour. The results will be discussed from methodological and content-related perspectives. [less ▲]

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See detailMulti-Channel Joint Forecasting-Scheduling for the Internet of Things
Rodoplu, Volkan; Nakip, Mert; Qorbanian, Roozbeh UL et al

in IEEE Access (2020), 8

We develop a methodology for Multi-Channel Joint Forecasting-Scheduling (MC-JFS) targeted at solving the Medium Access Control (MAC) layer Massive Access Problem of Machine-to-Machine (M2M) communication ... [more ▼]

We develop a methodology for Multi-Channel Joint Forecasting-Scheduling (MC-JFS) targeted at solving the Medium Access Control (MAC) layer Massive Access Problem of Machine-to-Machine (M2M) communication in the presence of multiple channels, as found in Orthogonal Frequency Division Multiple Access (OFDMA) systems. In contrast with the existing schemes that merely react to current traffic demand, Joint Forecasting-Scheduling (JFS) forecasts the traffic generation pattern of each Internet of Things (IoT) device in the coverage area of an IoT Gateway and schedules the uplink transmissions of the IoT devices over multiple channels in advance, thus obviating contention, collision and handshaking, which are found in reactive protocols. In this paper, we present the general form of a deterministic scheduling optimization program for MC-JFS that maximizes the total number of bits that are delivered over multiple channels by the delay deadlines of the IoT applications. In order to enable real-time operation of the MC-JFS system, first, we design a heuristic, called Multi-Channel Look Ahead Priority based on Average Load (MC-LAPAL), that solves the general form of the scheduling problem. Second, for the special case of identical channels, we develop a reduction technique by virtue of which an optimal solution of the scheduling problem is computed in real time. We compare the network performance of our MC-JFS scheme against Multi-Channel Reservation-based Access Barring (MC-RAB) and Multi-Channel Enhanced Reservation-based Access Barring (MC-ERAB), both of which serve as benchmark reactive protocols. Our results show that MC-JFS outperforms both MC-RAB and MC-ERAB with respect to uplink cross-layer throughput and transmit energy consumption, and that MC-LAPAL provides high performance as an MC-JFS heuristic. Furthermore, we show that the computation time of MC-LAPAL scales approximately linearly with the number of IoT devices. This work serves as a foundation for building scalable JFS schemes at IoT Gateways in the near future. [less ▲]

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See detailAuction-based Multi-Channel Cooperative Spectrum Sharing in Hybrid Satellite-Terrestrial IoT Networks
Zhang, Xiaokai; Guo, Daoxing; An, Kang et al

in IEEE Internet of Things Journal (2020)

In this paper, we investigate the multi-channel cooperative spectrum sharing in hybrid satellite-terrestrial internet of things (IoT) networks with the auction mechanism, which is designed to reduce the ... [more ▼]

In this paper, we investigate the multi-channel cooperative spectrum sharing in hybrid satellite-terrestrial internet of things (IoT) networks with the auction mechanism, which is designed to reduce the operational expenditure of the satellitebased IoT (S-IoT) network while alleviating the spectrum scarcity issues of terrestrial-based IoT (T-IoT) network. The cluster heads of selected T-IoT networks assist the primary satellite users transmission through cooperative relaying techniques in exchange for spectrum access. We propose an auction-based optimization problem to maximize the sum transmission rate of all primary S-IoT receivers with the appropriate secondary network selection and corresponding radio resource allocation profile by the distributed implementation while meeting the minimum transmission rate of secondary receivers of each TIoT network. Specifically, the one-shot Vickrey-Clarke-Groves (VCG) auction is introduced to obtain the maximum social welfare, where the winner determination problem is transformed into an assignment problem and solved by the Hungarian algorithm. To further reduce the primary satellite network decision complexity, the sequential Vickrey auction is implemented by sequential fashion until all channels are auctioned. Due to incentive compatibility with those two auction mechanisms, the secondary T-IoT cluster yields the true bids of each channel, where both the non-orthogonal multiple access (NOMA) and time division multiple access (TDMA) schemes are implemented in cooperative communication. Finally, simulation results validate the effectiveness and fairness of the proposed auction-based approach as well as the superiority of the NOMA scheme in secondary relays selection. Moreover, the influence of key factors on the performance of the proposed scheme is analyzed in detail. [less ▲]

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See detailTalking War: Representation, Veterans and Ideology in Post-War Parliamentary Debates
Mochtak, Michal UL; Glaurdic, Josip UL; Lesschaeve, Christophe UL

in Government and Opposition (2020), Online

How do politicians in post-war societies talk about the past war? How do they discursively represent vulnerable social groups created by the conflict? Does the nature of this representation depend on the ... [more ▼]

How do politicians in post-war societies talk about the past war? How do they discursively represent vulnerable social groups created by the conflict? Does the nature of this representation depend on the politicians’ ideology or their record of combat service? We answer these questions by pairing natural language processing tools and a large corpus of parliamentary debates with an extensive data set of biographical information including detailed records of war service for all members of parliament during two recent terms in Croatia. We demonstrate not only that veteran politicians talk about war differently from their non-veteran counterparts, but also that the sentiment of war-related political discourse is highly dependent on the speaker’s exposure to combat and ideological orientation. These results improve our understanding of the representational role played by combat veterans, as well as of the link between descriptive and substantive representation of vulnerable groups in post-war societies. [less ▲]

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See detailMitochondria interaction networks show altered topological patterns in Parkinson's disease.
Zanin, Massimiliano; Santos, Bruno F. R.; Antony, Paul UL et al

in NPJ systems biology and applications (2020), 6(1), 38

Mitochondrial dysfunction is linked to pathogenesis of Parkinson's disease (PD). However, individual mitochondria-based analyses do not show a uniform feature in PD patients. Since mitochondria interact ... [more ▼]

Mitochondrial dysfunction is linked to pathogenesis of Parkinson's disease (PD). However, individual mitochondria-based analyses do not show a uniform feature in PD patients. Since mitochondria interact with each other, we hypothesize that PD-related features might exist in topological patterns of mitochondria interaction networks (MINs). Here we show that MINs formed nonclassical scale-free supernetworks in colonic ganglia both from healthy controls and PD patients; however, altered network topological patterns were observed in PD patients. These patterns were highly correlated with PD clinical scores and a machine-learning approach based on the MIN features alone accurately distinguished between patients and controls with an area-under-curve value of 0.989. The MINs of midbrain dopaminergic neurons (mDANs) derived from several genetic PD patients also displayed specific changes. CRISPR/CAS9-based genome correction of alpha-synuclein point mutations reversed the changes in MINs of mDANs. Our organelle-interaction network analysis opens another critical dimension for a deeper characterization of various complex diseases with mitochondrial dysregulation. [less ▲]

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See detailEin Blick auf aktuelle Entwicklungen bei Blockchains und deren Auswirkungen auf den Energieverbrauch
Sedlmeir, Johannes; Ulrich Buhl, Hans; Fridgen, Gilbert UL et al

in Informatik-Spektrum (2020)

The enormous power consumption of Bitcoin has led to undifferentiated discussions in science and practice about the sustainability of blockchain and distributed ledger technology in general. However ... [more ▼]

The enormous power consumption of Bitcoin has led to undifferentiated discussions in science and practice about the sustainability of blockchain and distributed ledger technology in general. However, blockchain technology is far from homogeneous—not only with regard to its applications, which now go far beyond cryptocurrencies and have reached businesses and the public sector, but also with regard to its technical characteristics and, in particular, its power consumption. This paper summarizes the status quo of the power consumption of various implementations of blockchain technology, with special emphasis on the recent ‘‘Bitcoin Halving’’ and so-called ‘‘zk-rollups’’. We argue that although Bitcoin and other proof-of-work blockchains do indeed consume a lot of power, alternative blockchain solutions with significantly lower power consumption are already available today, and new promising concepts are being tested that could further reduce in particulary the power consumption of large blockchain networks in the near future. From this we conclude that although the criticism of Bitcoin’s power consumption is legitimate, it should not be used to derive an energy problem of blockchain technology in general. In many cases in which processes can be digitized or improved with the help of more energy-efficient blockchain variants, one can even expect net energy savings. [less ▲]

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See detailA UNIFORM RESULT FOR THE DIMENSION OF FRACTIONAL BROWNIAN MOTION LEVEL SETS
Daw, Lara UL

in Statistics and Probability Letters (2020)

Let B={Bt:t≥0} be a real-valued fractional Brownian motion of index H∈(0,1). We prove that the macroscopic Hausdorff dimension of the level sets Lx={t∈R+:Bt=x} is, with probability one, equal to 1−H for ... [more ▼]

Let B={Bt:t≥0} be a real-valued fractional Brownian motion of index H∈(0,1). We prove that the macroscopic Hausdorff dimension of the level sets Lx={t∈R+:Bt=x} is, with probability one, equal to 1−H for all x∈R. [less ▲]

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See detailFamily, Community and Long-Term Socioeconomic Inequality: Evidence from Siblings and Youth Peers
Bingley, Paul; Cappellari, Lorenzo; Tatsiramos, Konstantinos UL

in Economic Journal (2020)

Using administrative data for the population of Danish men and women, we develop an empirical model which accounts for the joint earnings dynamics of siblings and youth community peers. We provide the ... [more ▼]

Using administrative data for the population of Danish men and women, we develop an empirical model which accounts for the joint earnings dynamics of siblings and youth community peers. We provide the first decomposition of the sibling correlation of permanent earnings into family and community effects allowing for life-cycle dynamics, and extend the analysis to consider other outcomes. We find that family is the most important factor influencing sibling correlations of earnings, education and unemployment. Community background matters for shaping the sibling correlation of earnings and unemployment early in the working life, but its importance quickly diminishes. [less ▲]

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See detailUsing multi-member panels to tackle RSD complexities
Hambly, Jessica; Gill, Nick; Vianelli, Lorenzo UL

in Forced Migration Review (2020), (65), 32-35

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See detailTen years of re-thinking regions from citizens’ perspectives
Koff, Harlan UL; Maganda, Carmen; De Lombaerde, Philippe et al

in Regions and Cohesion (2020), 10(3), -

This special issue commemorating Regions & Cohesion’s tenth anniversary continues the tradition described herein. Entitled “Re-thinking regions: A citizen perspective,” it has been conceptualized and ... [more ▼]

This special issue commemorating Regions & Cohesion’s tenth anniversary continues the tradition described herein. Entitled “Re-thinking regions: A citizen perspective,” it has been conceptualized and coordinated by the journal’s editors, associate editors, and editorial manager. We thank the contributing authors for accepting the challenge to respond to any of the following provocative questions: What contributed to the perceived decline of regions in global affairs? How can regions recover from this perceived decline? How can supranational, transnational, or sub-national regions respond better to the needs of citizens? How can regions better support the Sustainable Development Goals and the transformative development that they pursue? How can regions promote more sustainable usage of natural resources? What roles can regions play in global affairs in the near- to medium-term future? The articles published here provide a snapshot of the state of regional integration in the world today. These articles also engage the field of regional studies, discuss its strengths and weaknesses, and indicate interesting paths for future scholarship. We thank the authors for these proposed ways forward. [less ▲]

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See detailLes comptes de la baumaîtrie de la ville de Luxembourg (1388-1500). État des lieux et perspectives de recherches
Pauly, Michel UL

in Comptabilité(S). Revue d'histoire des compatbilités (2020), 13

La contribution présente les comptes de la baumaîtrie de la ville de Luxembourg fort bien conservés pour la fin du 14e et le 15e siècle. Un inventaire des volumes conservés aux archives municipales est ... [more ▼]

La contribution présente les comptes de la baumaîtrie de la ville de Luxembourg fort bien conservés pour la fin du 14e et le 15e siècle. Un inventaire des volumes conservés aux archives municipales est suivi d’une description codicologique sommaire avant que ne soit esquissé le rôle du baumâitre, c.-à-d. du receveur central de la ville et celui du clerc-juré dans la confection des livres de compte ainsi que leur appartenance sociale et linguistique. L’article continue par un bilan de l’exploitation historiographique des livres de la baumaîtrie, y compris pour l’histoire de la langue, et par quelques questions de recherche qui mériteraient d’être approfondies. [less ▲]

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See detailRoles of bacteriophages, plasmids and CRISPR immunity in microbial community dynamics revealed using time-series integrated meta-omics
Martinez Arbas, Susana UL; Narayanasamy, Shaman; Herold, Malte et al

in Nature Microbiology (2020)

Viruses and plasmids (invasive mobile genetic elements (iMGEs)) have important roles in shaping microbial communities, but their dynamic interactions with CRISPR-based immunity remain unresolved. We ... [more ▼]

Viruses and plasmids (invasive mobile genetic elements (iMGEs)) have important roles in shaping microbial communities, but their dynamic interactions with CRISPR-based immunity remain unresolved. We analysed generation-resolved iMGE–host dynamics spanning one and a half years in a microbial consortium from a biological wastewater treatment plant using integrated meta-omics. We identified 31 bacterial metagenome-assembled genomes encoding complete CRISPR–Cas systems and their corresponding iMGEs. CRISPR-targeted plasmids outnumbered their bacteriophage counterparts by at least fivefold, highlighting the importance of CRISPR-mediated defence against plasmids. Linear modelling of our time-series data revealed that the variation in plasmid abundance over time explained more of the observed community dynamics than phages. Community-scale CRISPR-based plasmid–host and phage–host interaction networks revealed an increase in CRISPR-mediated interactions coinciding with a decrease in the dominant ‘Candidatus Microthrix parvicella’ population. Protospacers were enriched in sequences targeting genes involved in the transmission of iMGEs. Understanding the factors shaping the fitness of specific populations is necessary to devise control strategies for undesirable species and to predict or explain community-wide phenotypes. [less ▲]

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See detailAlterations in Neural Responses and Pain Perception in Older Adults During Distraction
Gonzalez-Roldan, Ana Maria; Terrasa, Juan Lorenzo; Sitges, Carolina et al

in Psychosomatic Medicine (2020), 82

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See detailBeam-inside-beam contact: Mechanical simulations of slender medical instruments inside the human body
Magliulo, Marco UL; Lengiewicz, Jakub UL; Zilian, Andreas UL et al

in Computer Methods and Programs in Biomedicine (2020), 196

Background and Objective This contribution presents a rapid computational framework to mechanically simulate the insertion of a slender medical instrument in a tubular structure such as an artery, the ... [more ▼]

Background and Objective This contribution presents a rapid computational framework to mechanically simulate the insertion of a slender medical instrument in a tubular structure such as an artery, the cochlea or another slender instrument. Methods Beams are employed to rapidly simulate the mechanical behaviour of the medical instrument and the tubular structure. However, the framework’s novelty is its capability to handle the mechanical contact between an inner beam (representing the medical instrument) embedded in a hollow outer beam (representing the tubular structure). This “beam-inside-beam” contact framework, which forces two beams to remain embedded, is the first of its kind since existing contact frameworks for beams are “beam-to-beam” approaches, i.e. they repel beams from each other. Furthermore, we propose contact kinematics such that not only instruments and tubes with circular cross-sections can be considered, but also those with elliptical cross-sections. This provides flexibility for the optimization of patient-specific instruments. Results The results demonstrate that the framework’s robustness is substantial, because only a few increments per simulation and a few iterations per increment are required, even though large deformations, large rotations and large curvature changes of both the instrument and tubular structure occur. The stability of the framework remains high even if the modulus of the inner tube is thousand times larger than that of the outer tube. A mesh convergence study furthermore exposes that a relatively small number of elements is required to accurately approach the reference solution. Conclusions The framework’s high simulation speed originates from the exploitation of the rigidity of the beams’ cross-sections to quantify the exclusion between the inner and the hollow outer beam. This rigidity limits the accuracy of the framework at the same time, but this is unavoidable since simulation accuracy and simulation speed are two competing interests. Hence, the framework is particularly attractive if simulation speed is preferred over accuracy. [less ▲]

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See detailDistraction from pain: The role of selective attention and pain catastrophizing
Rischer, Katharina Miriam UL; Gonzalez-Roldan, Ana Maria; Montoya, Pedro et al

in European Journal of Pain (2020), 24(10), 1880-1891

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See detailEditorial
Pigeron-Piroth, Isabelle UL; Belkacem, Rachid

in Les Cahiers de la Grande Région (2020), 3

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See detailARPANET, toute une histoire...
Schafer, Valerie UL

in 1024 : Bulletin de la Société Informatique de France (2020), (30),

Le lecteur pourra non seulement suivre l’évolution du traitement de l’histoire d’ARPANET − et en filigrane la manière dont celle de l’informatique et du numérique a connu des tournants, mais aussi peut ... [more ▼]

Le lecteur pourra non seulement suivre l’évolution du traitement de l’histoire d’ARPANET − et en filigrane la manière dont celle de l’informatique et du numérique a connu des tournants, mais aussi peut-être poursuivre par la lecture des auteurs cités un parcours qui sort des narrations linéaires et témoigne de la complexité de l’histoire d’ARPANET et de son actualité. [less ▲]

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See detailA Temporary Space Where Development and Planning Emergencies Meet? Notes on an International Building Exhibition (IBA) in the Cross- Border Territories of France and Luxembourg
Becker, Tom UL; Hesse, Markus UL

in Planning Theory & Practice (2020)

An International Building Exhibition (IBA) is currently being planned for the cross-border area of southern Luxembourg and north-eastern France (Alzette-Belval). This planning approach, mainly known in ... [more ▼]

An International Building Exhibition (IBA) is currently being planned for the cross-border area of southern Luxembourg and north-eastern France (Alzette-Belval). This planning approach, mainly known in the German building and planning context, was developed as a temporary activity to foster planning innovation and experimentation, in order to bring both formal and informal processes and regulations forward. Some have also argued that an IBA can be considered a temporary case of planning emergency, a means for trying the unusual in settings where business as usual has failed to address important problems properly. Organising an IBA has recently become increasingly popular in other European countries, such as Austria, the Netherlands or Switzerland. The aim of this note is to address some general questions as to the particular role that this instrument can play, and what it may promise (and not) to spatial planning. We also discuss the specific framework conditions and problems the French-Luxembourgian border region is confronted with. Our comment should contribute to clarifying what the underlying problems are actually about and, more specifically, in what ways an IBA could help dealing with them. Particularly, we suggest decision-makers and practitioners to follow a practice of ‘reflection before selection’: to address the very specificities of both the region and of an IBA before turning to ‘project’-based routines. This would avoid rendering the IBA as an empty signifier or a mere branding tool, while practice remains challenged by vested interests, complex policy terrains and powerful political economies. [less ▲]

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See detailSystem Modelling and Design Aspects of Next Generation High Throughput Satellites
Sharma, Shree Krishna UL; Querol, Jorge UL; Maturo, Nicola UL et al

in IEEE Communications Letters (2020)

As compared to terrestrial systems, the design of Satellite Communication (SatCom) systems require a different approach due to differences in terms of wave propagation, operating frequency, antenna ... [more ▼]

As compared to terrestrial systems, the design of Satellite Communication (SatCom) systems require a different approach due to differences in terms of wave propagation, operating frequency, antenna structures, interfering sources, limitations of onboard processing, power limitations and transceiver impairments. In this regard, this letter aims to identify and discuss important modeling and design aspects of the next generation High Throughput Satellite (HTS) systems. First, communication models of HTSs including the ones for multibeam and multicarrier satellites, multiple antenna techniques, and for SatCom payloads and antennas are highlighted and discussed. Subsequently, various design aspects of SatCom transceivers including impairments related to the transceiver, payload and channel, and traffic-based coverage adaptation are presented. Finally, some open topics for the design of next generation HTSs are identified and discussed. [less ▲]

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See detailBarriers and Borders: Human Mobility and Building Inclusive Societies
Graham, Suzanne; Koff, Harlan UL

in Politikon: South African Journal of Political Studies (2020), 47(4), 2-5

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See detailOversampled DFT-Modulated Biorthogonal Filter Banks: Perfect Reconstruction Designs and Multiplierless Approximations
Alves Martins, Wallace UL; Shankar, Bhavani UL; Ottersten, Björn UL

in IEEE Transactions on Circuits and Systems. II, Express Briefs (2020), 67(11), 2777-2781

We propose a novel methodology for designing oversampled discrete Fourier transform-modulated uniform filter banks. The analysis prototype is designed as a Nyquist filter, whereas the synthesis prototype ... [more ▼]

We propose a novel methodology for designing oversampled discrete Fourier transform-modulated uniform filter banks. The analysis prototype is designed as a Nyquist filter, whereas the synthesis prototype is designed to guarantee perfect reconstruction (PR) considering oversampling. The resulting optimization problem fits into the disciplined convex programming framework, as long as some convex objective function is employed, as the minimization of either the stop-band energy or the maximum deviation from a desired response. The methodology also accounts for near-PR multiplierless approximations of the prototype analysis and synthesis filters, whose coefficients are obtained in the sum-of-power-of-two (SOPOT) space. The quantized coefficients are computed using successive approximation of vectors, which is able to yield filters with a reduced number of SOPOT coefficients in a computationally efficient manner. The proposed methodology is especially appealing for supporting actual hardware deployments, such as modern digital transparent processors to be used in next-generation satellite payloads. [less ▲]

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See detailA Big Data Demand Estimation Model for Urban Congested Networks
Cantelmo, Guido; Viti, Francesco UL

in Transport and Telecommunication (2020)

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See detailMechanisms of Ras Membrane Organization and Signaling: Ras Rocks Again.
Abankwa, Daniel UL; Gorfe, Alemayehu A.

in Biomolecules (2020), 10(11),

Ras is the most frequently mutated oncogene and recent drug development efforts have spurred significant new research interest. Here we review progress toward understanding how Ras functions in nanoscale ... [more ▼]

Ras is the most frequently mutated oncogene and recent drug development efforts have spurred significant new research interest. Here we review progress toward understanding how Ras functions in nanoscale, proteo-lipid signaling complexes on the plasma membrane, called nanoclusters. We discuss how G-domain reorientation is plausibly linked to Ras-nanoclustering and -dimerization. We then look at how these mechanistic features could cooperate in the engagement and activation of RAF by Ras. Moreover, we show how this structural information can be integrated with microscopy data that provide nanoscale resolution in cell biological experiments. Synthesizing the available data, we propose to distinguish between two types of Ras nanoclusters, an active, immobile RAF-dependent type and an inactive/neutral membrane anchor-dependent. We conclude that it is possible that Ras reorientation enables dynamic Ras dimerization while the whole Ras/RAF complex transits into an active state. These transient di/oligomer interfaces of Ras may be amenable to pharmacological intervention. We close by highlighting a number of open questions including whether all effectors form active nanoclusters and whether there is an isoform specific composition of Ras nanocluster. [less ▲]

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See detailDer Wert digitaler Güter - Steuerrechtliche Einordnung
Sinnig, Julia UL

in Kommunikation und Recht (2020)

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See detailComprehensive Physical Layer Security Analysis of FSO Communications over Malaga Channels
Ai, Yun; Mathur, Aashish; Verma, Gyan Deep et al

in IEEE Photonics Journal (2020)

In this paper, we study the physical layer security of free-space optical (FSO) communications under different eavesdropping scenarios. More specifically, the secrecy performance of FSO communication ... [more ▼]

In this paper, we study the physical layer security of free-space optical (FSO) communications under different eavesdropping scenarios. More specifically, the secrecy performance of FSO communication employing intensity modulation/direct detection detection is analyzed for the well-established Mlaga channels. Three different realistic scenarios of eavesdropping are considered by assuming different placement locations for the eavesdropper in the paper. Novel expressions for the average secrecy capacity (ASC) and secrecy outage probability (SOP) are derived for the considered scenarios, and useful insights are also provided through asymptotic analysis. The results show: (i) When the eavesdropper is placed near the transmitter, atmospheric condition imposes a less significant impact on secrecy performance; (ii) Certain level of correlation can potentially enhance the secrecy performance for FSO communications; (iii) The correlation imposes opposite impacts on the ASC and SOP of FSO communications; and the secrecy performance metrics exhibit a non-monotonic impact with the increase of correlation; (v) When the correlation of the FSO links is too small or too large (i.e., the correlation parameter around 0 or 1), the correlation plays a more significant impact on secrecy performance; and (vi) The asymptotic slope of the SOP is 0.5 for all eavesdropping scenarios under practical FSO channels. [less ▲]

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See detailPerformance of lime-metakaolin pastes using gravel wash mud (GWM)
Thapa, Vishojit Bahadur UL; Waldmann, Daniele UL

in Cement and Concrete Composites (2020), 114(103772),

The performance of ternary binders using lime, metakaolin (MK) and gravel wash mud (GWM) powders is studied for the development of novel lime-pozzolan pastes. This study examines the influence of varying ... [more ▼]

The performance of ternary binders using lime, metakaolin (MK) and gravel wash mud (GWM) powders is studied for the development of novel lime-pozzolan pastes. This study examines the influence of varying mixture proportions using different types and compositions of lime powders and GWM at different treatment levels on the mechanical properties of lime-MK-GWM pastes. Various characterisation techniques including particle size distribution (PSD), X-ray fluorescence (XRF), X-ray diffraction (XRD), compressive strength tests, simultaneous thermal analysis (STA) and scanning electron microscopy (SEM), were applied on the different raw materials, respectively, on the hardened pastes to determine the reaction kinetics, the resulting microstructure and the mechanical performances of the lime-MK-GWM binder systems. Higher strength-enhancing contributions of thermally treated GWM powders (calcined at 850°C) leading to compressive strengths up to 18 MPa were confirmed and the strength-based evaluations revealed that hydrated lime-based pastes achieved higher mechanical performances than hydraulic lime-based binder systems. [less ▲]

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See detailChanges in Neighborhood-Level Concentrated Disadvantage and Social Networks Among Older Americans
Settels, Jason UL

in Journal of Applied Gerontology (2020)

Close social networks provide older persons with resources, including social support, that maintain their well-being. While scholarship shows how networks change over time, a dearth of research ... [more ▼]

Close social networks provide older persons with resources, including social support, that maintain their well-being. While scholarship shows how networks change over time, a dearth of research investigates changing social contexts as causes of network dynamics. Using the first two waves of the National Social Life, Health, and Aging Project survey (N = 1,776), this study shows how rising neighborhood-level concentrated disadvantage through the Great Recession of 2007–2009 was associated with smaller close networks, largely due to fewer new close ties gained, among older Americans. Worsening neighborhood circumstances pose obstacles to older residents’ acquisition of new close ties, including heightened fear, lower generalized trust, stress and depression, and declines in local institutions that attract both residents and nonresidents. [less ▲]

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See detailOptimised biomolecular extraction for metagenomic analysis of microbial biofilms from high-mountain streams
Busi, Susheel Bhanu UL; Pramateftaki, Paraskevi; Brandani, Jade et al

in PeerJ (2020)

Glacier-fed streams (GFS) are harsh ecosystems dominated by microbial life organized in benthic biofilms, yet the biodiversity and ecosystem functions provided by these communities remain under ... [more ▼]

Glacier-fed streams (GFS) are harsh ecosystems dominated by microbial life organized in benthic biofilms, yet the biodiversity and ecosystem functions provided by these communities remain under-appreciated. To better understand the microbial processes and communities contributing to GFS ecosystems, it is necessary to leverage high throughput sequencing. Low biomass and high inorganic particle load in GFS sediment samples may affect nucleic acid extraction efficiency using extraction methods tailored to other extreme environments such as deep-sea sediments. Here, we benchmarked the utility and efficacy of four extraction protocols, including an up-scaled phenol-chloroform protocol. We found that established protocols for comparable sample types consistently failed to yield sufficient high-quality DNA, delineating the extreme character of GFS. The methods differed in the success of downstream applications such as library preparation and sequencing. An adapted phenol-chloroform-based extraction method resulted in higher yields and better recovered the expected taxonomic profile and abundance of reconstructed genomes when compared to commercially-available methods. Affordable and straight-forward, this method consistently recapitulated the abundance and genomes of a mock community, including eukaryotes. Moreover, by increasing the amount of input sediment, the protocol is readily adjustable to the microbial load of the processed samples without compromising protocol efficiency. Our study provides a first systematic and extensive analysis of the different options for extraction of nucleic acids from glacier-fed streams for high-throughput sequencing applications, which may be applied to other extreme environments. [less ▲]

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See detailComprehensive characterization of amino acidpositions in protein structures reveals moleculareffect of missense variants
iqbal, Sumaiya; Perez-Palma, Eduardo; Jespersen, Jakob B. et al

in Proceedings of the National Academy of Sciences of the United States of America (2020)

Interpretation of the colossal number of genetic variants identified from sequencing applications is one of the major bottlenecks in clinical genetics, with the inference of the effect of amino acid ... [more ▼]

Interpretation of the colossal number of genetic variants identified from sequencing applications is one of the major bottlenecks in clinical genetics, with the inference of the effect of amino acid-substituting missense variations on protein structure and function being especially challenging. Here we characterize the three-dimensional (3D) amino acid positions affected in pathogenic and population variants from 1,330 disease-associated genes using over 14,000 experimentally solved human protein structures. By measuring the statistical burden of variations (i.e., point mutations) from all genes on 40 3D protein features, accounting for the structural, chemical, and functional context of the variations’ positions, we identify features that are generally associated with pathogenic and population missense variants. We then perform the same amino acid-level analysis individually for 24 protein functional classes, which reveals unique characteristics of the positions of the altered amino acids: We observe up to 46% divergence of the class-specific features from the general characteristics obtained by the analysis on all genes, which is consistent with the structural diversity of essential regions across different protein classes. We demonstrate that the function-specific 3D features of the variants match the readouts of mutagenesis experiments for BRCA1 and PTEN, and positively correlate with an independent set of clinically interpreted pathogenic and benign missense variants. Finally, we make our results available through a web server to foster accessibility and downstream research. Our findings represent a crucial step toward translational genetics, from highlighting the impact of mutations on protein structure to rationalizing the variants’ pathogenicity in terms of the perturbed molecular mechanisms. [less ▲]

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See detailFoxO maintains a genuine muscle stem-cell quiescent state until geriatric age
Del Sol Mesa, Antonio UL

in Nature Cell Biology (2020)

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See detailThe Framework of Security-Enhancing Friction: How UX Can Help Users Behave More Securely
Distler, Verena UL; Lenzini, Gabriele UL; Lallemand, Carine UL et al

in New Security Paradigms Workshop (2020)

A growing body of research in the usable privacy and security community addresses the question of how to best influence user behavior to reduce risk-taking.We propose to address this challenge by ... [more ▼]

A growing body of research in the usable privacy and security community addresses the question of how to best influence user behavior to reduce risk-taking.We propose to address this challenge by integrating the concept of User Experience (UX) into empirical usable privacy and security studies that attempt to change risk-taking behavior. UX enables us to study the complex interplay between user-related, system-related and contextual factors and provides insights into the experiential aspects underlying behavior change, including negative experiences. We first compare and contrast existing security-enhancing interventions (e.g., nudges, warnings, fear appeals) through the lens of friction. We then build on these insights to argue that it can be desirable to design for moments of negative UX in security-critical situations. For this purpose, we introduce the novel concept of security-enhancing friction, friction that effectively reduces the occurrence of risk-taking behavior and ensures that the overall UX (after use) is not compromised. We illustrate how security-enhancing friction provides an actionable way to systematically integrate the concept of UX into empirical usable privacy and security studies for meeting both the objectives of secure behavior and of overall acceptable experience. [less ▲]

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See detailDiscordant Monozygotic Parkinson Disease Twins: Role of Mitochondrial Integrity
Dulovic-Mahlow, Marija; König, Inke R.; Trinh, Joanne et al

in Annals of Neurology (2020)

Objective Even though genetic predisposition has proven to be an important element in Parkinson's disease (PD) etiology, monozygotic (MZ) twins with PD displayed a concordance rate of only about 20 ... [more ▼]

Objective Even though genetic predisposition has proven to be an important element in Parkinson's disease (PD) etiology, monozygotic (MZ) twins with PD displayed a concordance rate of only about 20% despite their shared identical genetic background. Methods We recruited 5 pairs of MZ twins discordant for idiopathic PD and established skin fibroblast cultures to investigate mitochondrial phenotypes in these cellular models against the background of a presumably identical genome. To test for genetic differences, we performed whole genome sequencing, deep mitochondrial DNA (mtDNA) sequencing, and tested for mitochondrial deletions by multiplex real‐time polymerase chain reaction (PCR) in the fibroblast cultures. Further, the fibroblast cultures were tested for mitochondrial integrity by immunocytochemistry, immunoblotting, flow cytometry, and real‐time PCR to quantify gene expression. Results Genome sequencing did not identify any genetic difference. We found decreased mitochondrial functionality with reduced cellular adenosine triphosphate (ATP) levels, altered mitochondrial morphology, elevated protein levels of superoxide dismutase 2 (SOD2), and increased levels of peroxisome proliferator‐activated receptor‐gamma coactivator‐α (PPARGC1A) messenger RNA (mRNA) in skin fibroblast cultures from the affected compared to the unaffected twins. Further, there was a tendency for a higher number of somatic mtDNA variants among the affected twins. Interpretation We demonstrate disease‐related differences in mitochondrial integrity in the genetically identical twins. Of note, the clinical expression matches functional alterations of the mitochondria [less ▲]

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See detailIntegration of time-series meta-omics data reveals how microbial ecosystems respond to disturbance
Herold, Malte; Martinez Arbas, Susana UL; Narayanasamy, Shaman et al

in Nature Communications (2020)

The development of reliable, mixed-culture biotechnological processes hinges on understanding how microbial ecosystems respond to disturbances. Here we reveal extensive phenotypic plasticity and niche ... [more ▼]

The development of reliable, mixed-culture biotechnological processes hinges on understanding how microbial ecosystems respond to disturbances. Here we reveal extensive phenotypic plasticity and niche complementarity in oleaginous microbial populations from a biological wastewater treatment plant. We perform meta-omics analyses (metagenomics, metatranscriptomics, metaproteomics and metabolomics) on in situ samples over 14 months at weekly intervals. Based on 1,364 de novo metagenome-assembled genomes, we uncover four distinct fundamental niche types. Throughout the time-series, we observe a major, transient shift in community structure, coinciding with substrate availability changes. Functional omics data reveals extensive variation in gene expression and substrate usage amongst community members. Ex situ bioreactor experiments confirm that responses occur within five hours of a pulse disturbance, demonstrating rapid adaptation by specific populations. Our results show that community resistance and resilience are a function of phenotypic plasticity and niche complementarity, and set the foundation for future ecological engineering efforts. [less ▲]

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See detailA scalable method to construct compact road networks from GPS trajectories
Guo, Yuejun UL; Bardera, Anton; FOrt, Marta et al

in International Journal of Geographical Information Science (2020), 0(0), 1-37

The automatic generation of road networks from GPS tracks is a challenging problem that has been receiving considerable attention in the last years. Although dozens of methods have been proposed, current ... [more ▼]

The automatic generation of road networks from GPS tracks is a challenging problem that has been receiving considerable attention in the last years. Although dozens of methods have been proposed, current techniques suffer from two main shortcomings: the quality of the produced road networks is still far from those produced manually, and the methods are slow, making them not scalable to large inputs. In this paper, we present a fast four-step density-based approach to construct a road network from a set of trajectories. A key aspect of our method is the use of an improved version of the Slide method to adjust trajectories to build a more compact density surface. The network has comparable or better quality than that of state-of-the-art methods and is simpler (includes fewer nodes and edges). Furthermore, we also propose a split-and-merge strategy that allows splitting the data domain into smaller regions that can be processed independently, making the method scalable to large inputs. The performance of our method is evaluated with extensive experiments on urban and hiking data. [less ▲]

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See detailSummertime Overheating Risk Assessment of a Flexible Plug-in Modular Unit in Luxembourg
Rakotonjanahary, Tahiana Roland Michaël UL; Scholzen, Frank UL; Waldmann, Daniele UL

in Sustainability (2020)

Modular buildings offer faster construction process, provide better construction quality, allow reducing construction waste and are potentially flexible. Frames of modular units can be made of metal ... [more ▼]

Modular buildings offer faster construction process, provide better construction quality, allow reducing construction waste and are potentially flexible. Frames of modular units can be made of metal, timber, concrete or mixed materials but lightweight structures do not always allow erecting high-rise buildings and generally present a higher risk of overheating and/or overcooling. To reconcile these pros and cons, a typology of modular building called Slab was designed by a group of architects. The building is composed on the one hand of a permanent concrete structure named shelf-structure and on the other hand of several flexible removable timber modular units, also known as modules. The shelf-structure will host the common utility rooms and will serve as docking infrastructure for the housing modules. To provide high flexibility, the Slab building was designed to adapt to any orientation and location in Luxembourg. An energy concept and a HVAC systems design has been developed for the Slab building. Furthermore, a two-fold sustainability analysis was carried out. The first part of the analysis regards the determination of the minimum required wall thicknesses of the modules in accordance with Luxembourgish regulatory requirements, although the current regulation does not yet consider the Slab building typology. The second part, which is the subject of this paper, is thermal comfort assessment, more precisely, summertime overheating risk assessment of these modules, in compliance with Luxembourgish standard. In this regard, dynamic thermal simulations have been realized on two module variants; the first fulfills the passive house requirements, and the second—the current requirements for building permit application, which in principle corresponds to low energy house requirements. Simulations showed that with adequate solar shading and reinforced natural ventilation by window opening, overheating risk could be avoided for the normal residential use scenario for both module variants. [less ▲]

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See detailEvolutionary algorithms deceive humans and machines at image classification: An extended proof of concept on two scenarios
Chitic, Ioana Raluca UL; Leprevost, Franck UL; Bernard, Nicolas

in Journal of Information and Telecommunication (2020)

The range of applications of Neural Networks encompasses image classification. However, Neural Networks are vulnerable to attacks, and may misclassify adversarial images, leading to potentially disastrous ... [more ▼]

The range of applications of Neural Networks encompasses image classification. However, Neural Networks are vulnerable to attacks, and may misclassify adversarial images, leading to potentially disastrous consequences. Pursuing some of our previous work, we provide an extended proof of concept of a black-box, targeted, non-parametric attack using evolutionary algorithms to fool both Neural Networks and humans at the task of image classification. Our feasibility study is performed on VGG-16 trained on CIFAR-10. For any category cA of CIFAR-10, one chooses an image A classified by VGG-16 as belonging to cA. From there, two scenarios are addressed. In the first scenario, a target category ct≠cA is fixed a priori. We construct an evolutionary algorithm that evolves A to a modified image that VGG-16 classifies as belonging to ct. In the second scenario, we construct another evolutionary algorithm that evolves A to a modified image that VGG-16 is unable to classify. In both scenarios, the obtained adversarial images remain so close to the original one that a human would likely classify them as still belonging to cA. [less ▲]

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See detailMitochondrial damage-associated inflammation highlights biomarkers in PRKN/PINK1 parkinsonism
Borsche, Max; Koenig, Inke; Delcambre, Sylvie UL et al

in Brain: a Journal of Neurology (2020)

There is increasing evidence for a role of inflammation in Parkinson’s disease. Recent research in murine models suggests that parkin and PINK1 deficiency leads to impaired mitophagy, which causes the ... [more ▼]

There is increasing evidence for a role of inflammation in Parkinson’s disease. Recent research in murine models suggests that parkin and PINK1 deficiency leads to impaired mitophagy, which causes the release of mitochondrial DNA (mtDNA), thereby triggering inflammation. Specifically, the CGAS (cyclic GMP-AMP synthase)-STING (stimulator of interferon genes) pathway mitigates activation of the innate immune system, quantifiable as increased interleukin-6 (IL6) levels. However, the role of IL6 and circulating cell-free mtDNA in unaffected and affected individuals harbouring mutations in PRKN/PINK1 and idiopathic Parkinson’s disease patients remain elusive. We investigated IL6, C-reactive protein, and circulating cell-free mtDNA in serum of 245 participants in two cohorts from tertiary movement disorder centres. We performed a hypothesis-driven rank-based statistical approach adjusting for multiple testing. We detected (i) elevated IL6 levels in patients with biallelic PRKN/PINK1 mutations compared to healthy control subjects in a German cohort, supporting the concept of a role for inflammation in PRKN/PINK1-linked Parkinson’s disease. In addition, the comparison of patients with biallelic and heterozygous mutations in PRKN/PINK1 suggests a gene dosage effect. The differences in IL6 levels were validated in a second independent Italian cohort; (ii) a correlation between IL6 levels and disease duration in carriers of PRKN/PINK1 mutations, while no such association was observed for idiopathic Parkinson’s disease patients. These results highlight the potential of IL6 as progression marker in Parkinson’s disease due to PRKN/PINK1 mutations; (iii) increased circulating cell-free mtDNA serum levels in both patients with biallelic or with heterozygous PRKN/PINK1 mutations compared to idiopathic Parkinson’s disease, which is in line with previous findings in murine models. By contrast, circulating cell-free mtDNA concentrations in unaffected heterozygous carriers of PRKN/PINK1 mutations were comparable to control levels; and (iv) that circulating cell-free mtDNA levels have good predictive potential to discriminate between idiopathic Parkinson’s disease and Parkinson’s disease linked to heterozygous PRKN/PINK1 mutations, providing functional evidence for a role of heterozygous mutations in PRKN or PINK1 as Parkinson’s disease risk factor. Taken together, our study further implicates inflammation due to impaired mitophagy and subsequent mtDNA release in the pathogenesis of PRKN/PINK1-linked Parkinson’s disease. In individuals carrying mutations in PRKN/PINK1, IL6 and circulating cell-free mtDNA levels may serve as markers of Parkinson’s disease state and progression, respectively. Finally, our study suggests that targeting the immune system with anti-inflammatory medication holds the potential to influence the disease course of Parkinson’s disease, at least in this subset of patients. [less ▲]

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See detailHaploinsufficiency due to a novel ACO2 deletion causes mitochondrial dysfunction in fibroblasts from a patient with dominant optic nerve atrophy
Neumann, Marie Anne-Catherine UL; Grossmann, Dajana UL; Schimpf-Linzenbold, Simone et al

in Scientific Reports (2020)

ACO2 is a mitochondrial protein, which is critically involved in the function of the tricarboxylic acid cycle (TCA), the maintenance of iron homeostasis, oxidative stress defense and the integrity of ... [more ▼]

ACO2 is a mitochondrial protein, which is critically involved in the function of the tricarboxylic acid cycle (TCA), the maintenance of iron homeostasis, oxidative stress defense and the integrity of mitochondrial DNA (mtDNA). Mutations in the ACO2 gene were identified in patients suffering from a broad range of symptoms, including optic nerve atrophy, cortical atrophy, cerebellar atrophy, hypotonia, seizures and intellectual disabilities. In the present study, we identified a heterozygous 51 bp deletion (c.1699_1749del51) in ACO2 in a family with autosomal dominant inherited isolated optic atrophy. A complementation assay using aco1-deficient yeast revealed a growth defect for the mutant ACO2 variant substantiating a pathogenic effect of the deletion. We used patient-derived fibroblasts to characterize cellular phenotypes and found a decrease of ACO2 protein levels, while ACO2 enzyme activity was not affected compared to two age- and gender-matched control lines. Several parameters of mitochondrial function, including mitochondrial morphology, mitochondrial membrane potential or mitochondrial superoxide production, were not changed under baseline conditions. However, basal respiration, maximal respiration, and spare respiratory capacity were reduced in mutant cells. Furthermore, we observed a reduction of mtDNA copy number and reduced mtDNA transcription levels in ACO2-mutant fibroblasts. Inducing oxidative stress led to an increased susceptibility for cell death in ACO2-mutant fibroblasts compared to controls. Our study reveals that a monoallelic mutation in ACO2 is sufficient to promote mitochondrial dysfunction and increased vulnerability to oxidative stress as main drivers of cell death related to optic nerve atrophy. [less ▲]

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See detailA pluralistic and integrated approach to action-oriented knowledge for sustainability
Caniglia, Guido; Luederitz, Christopher; von Wirth, Timo et al

in Nature Sustainability (2020)

Sustainability science needs more systematic approaches for mobilizing knowledge in support of interventions that may bring about transformative change. In this Perspective, we contend that action ... [more ▼]

Sustainability science needs more systematic approaches for mobilizing knowledge in support of interventions that may bring about transformative change. In this Perspective, we contend that action-oriented knowledge for sustainability emerges when working in integrated ways with the many kinds of knowledge involved in the shared design, enactment and realization of change. The pluralistic and integrated approach we present rejects technocratic solutions to complex sustainability challenges and foregrounds individual and social learning. We argue that research institutions devoted to sustainability should focus more on creating the conditions for experimenting with multiple kinds of knowledge and ways of knowing to foster sustainability-oriented learning. [less ▲]

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See detailDoes Motivation in Physical Education Have an Impact on Out-of-School Physical Activity over Time? A Longitudinal Approach
Hutmacher, Djenna UL; Eckelt, Melanie UL; Bund, Andreas UL et al

in International Journal of Environmental Research and Public Health (2020), 17(19), 7258

Previous research based on the trans-contextual model proposes that autonomous motivation in physical education (PE) is transferable to an out-of-school leisure-time (LT) context. However, only cross ... [more ▼]

Previous research based on the trans-contextual model proposes that autonomous motivation in physical education (PE) is transferable to an out-of-school leisure-time (LT) context. However, only cross-sectional and unidirectional analyses have been conducted. The present study used a longitudinal design assessing N = 1681 students (M = 14.68 years) on two occasions, measuring the following constructs: perceived need for support in PE, motivational regulation during PE and LT, attitude, subjective norm, perceived behavioral control, intention, and physical activity behavior. Findings based on mixed effect models revealed that autonomy, competence, and relatedness support of the PE teacher were positively related to autonomous motivation. Moreover, similar motivational regulation types were found to significantly cross-lag across contexts. Through longitudinal mediation analyses, further support for the impact of autonomous motivation on physical activity, mediated by intention, attitude, and perceived behavioral control, was found. Suggestions for educational stakeholders regarding how to promote students’ autonomous motivation are provided. [less ▲]

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See detailPatient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology.
Golebiewska, Anna UL; Hau, Ann-Christin; Oudin, Anaïs et al

in Acta neuropathologica (2020)

Patient-based cancer models are essential tools for studying tumor biology and for the assessment of drug responses in a translational context. We report the establishment a large cohort of unique ... [more ▼]

Patient-based cancer models are essential tools for studying tumor biology and for the assessment of drug responses in a translational context. We report the establishment a large cohort of unique organoids and patient-derived orthotopic xenografts (PDOX) of various glioma subtypes, including gliomas with mutations in IDH1, and paired longitudinal PDOX from primary and recurrent tumors of the same patient. We show that glioma PDOXs enable long-term propagation of patient tumors and represent clinically relevant patient avatars that retain histopathological, genetic, epigenetic, and transcriptomic features of parental tumors. We find no evidence of mouse-specific clonal evolution in glioma PDOXs. Our cohort captures individual molecular genotypes for precision medicine including mutations in IDH1, ATRX, TP53, MDM2/4, amplification of EGFR, PDGFRA, MET, CDK4/6, MDM2/4, and deletion of CDKN2A/B, PTCH, and PTEN. Matched longitudinal PDOX recapitulate the limited genetic evolution of gliomas observed in patients following treatment. At the histological level, we observe increased vascularization in the rat host as compared to mice. PDOX-derived standardized glioma organoids are amenable to high-throughput drug screens that can be validated in mice. We show clinically relevant responses to temozolomide (TMZ) and to targeted treatments, such as EGFR and CDK4/6 inhibitors in (epi)genetically defined subgroups, according to MGMT promoter and EGFR/CDK status, respectively. Dianhydrogalactitol (VAL-083), a promising bifunctional alkylating agent in the current clinical trial, displayed high therapeutic efficacy, and was able to overcome TMZ resistance in glioblastoma. Our work underscores the clinical relevance of glioma organoids and PDOX models for translational research and personalized treatment studies and represents a unique publicly available resource for precision oncology. [less ▲]

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See detailAccelerating fatigue simulations of a phase-field damage model for rubber
Loew, Pascal Juergen UL; Poh, Leong Hien; Peters, Bernhard UL et al

in Computer Methods in Applied Mechanics and Engineering (2020), 370(113247),

Phase-field damage models are able to describe crack nucleation as well as crack propagation and coalescence without additional technicalities, because cracks are treated in a continuous, spatially finite ... [more ▼]

Phase-field damage models are able to describe crack nucleation as well as crack propagation and coalescence without additional technicalities, because cracks are treated in a continuous, spatially finite manner. Previously, we have developed a phase-field model to capture the rate-dependent failure of rubber, and we have further enhanced it to describe failure due to cyclic loading. Although the model accurately describes fatigue failure, the associated cyclic simulations are slow. Therefore, this contribution presents an acceleration scheme for cyclic simulations of our previously introduced phase-field damage model so that the simulation speed is increased to facilitate large-scale simulations of industrially relevant problems. We formulate an explicit and an implicit cycle jump method, which, depending on the selected jump size, reduce the calculation time up to 99.5%. To circumvent the manual tuning of the jump size, we also present an adaptive jump size selection procedure. Thanks to the implicit adaptive scheme, all material parameters are identified from experiments, which include fatigue crack nucleation and crack growth. Finally, the model and its parameters are validated with additional measurements of the fatigue crack growth rate. [less ▲]

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See detailMitochondria and Parkinson's Disease: Clinical, Molecular, and Translational Aspects
Borsche, Max; Pereira, Sandro; Klein, Christine et al

in Journal of Parkinson's Disease (2020)

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See detailAge at Onset of LRRK2 p.Gly2019Ser Is Related to Environmental and Lifestyle Factors
Lüth, Theresa; König, Inke R; Grünewald, Anne UL et al

in Movement Disorders (2020), 35(10), 1854-1858

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See detailGeneration of two iPS cell lines (HIHDNDi001-A and HIHDNDi001-B) from a Parkinson's disease patient carrying the heterozygous p.A30P mutation in SNCA.
Barbuti, Peter; Santos, Bruno; Dording, Claire UL et al

in Stem cell research (2020), 48

Dermal fibroblasts from a patient carrying a heterozygous c.88G > C mutation in the SNCA gene that encodes alpha-synuclein were reprogrammed to pluripotency by retroviruses. This pathogenic mutation ... [more ▼]

Dermal fibroblasts from a patient carrying a heterozygous c.88G > C mutation in the SNCA gene that encodes alpha-synuclein were reprogrammed to pluripotency by retroviruses. This pathogenic mutation generates the p.A30P form of the alpha-synuclein protein leading to autosomal dominantly inherited Parkinson's disease (PD). Two clonal iPS cell lines were generated (A30P-3 and A30P-4) and characterised by validating the silencing of viral transgenes, the expression of endogenous pluripotency genes, directed differentiation into three germ layers in-vitro and a stable molecular genotype. These iPSC lines will serve as a valuable resource in determining the role of the p.A30P SNCA mutation in PD pathogenesis. [less ▲]

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See detailClassification of universal formality maps for quantizations of Lie bialgebras
Merkulov, Sergei UL; Willwacher, Thomas

in Compositio Mathematica (2020), 156(10), 2111-2148

We introduce an endofunctor D in the category of augmented props with the property that for any representation of a prop P in a vector space V the associated prop DP admits an induced representation on ... [more ▼]

We introduce an endofunctor D in the category of augmented props with the property that for any representation of a prop P in a vector space V the associated prop DP admits an induced representation on the graded commutative tensor algebra S(V) given in terms of polydifferential operators. Applying this functor to the prop LieB of Lie bialgebras we show that universal formality maps for quantizations of Lie bialgebras are in in 1-1 correspondence with prop morphisms from the minimal resolution AssB_infty of the prop of associative bialgebras to the polydifferential prop DLieB_infty satisfying certain boundary conditions. We prove that the set of such formality morphisms (having an extra property of being Lie connected) is non-empty. The latter result is used in turn to give a short proof of the formality theorem for universal quantizations of arbitrary Lie bialgebras which says that for any Drinfeld associator there is an associated Lie_infty quasi-isomorphism between the Lie_infty algebras controlling, respectively, deformations of the standard bialgebra structure in S(V) and deformations of any given Lie bialgebra structure in V. We study the deformation complex of an arbitrary universal formality morphism and show that it is quasi-isomorphic (up to one class corresponding to the standard rescaling automorphism of the properad LieB) to the oriented graph complex GC or 3 studied earlier in \cite{Wi2}. This result gives a complete classification of the set of gauge equivalence classes of universal Lie connected formality maps --- it is a torsor over the Grothendieck-Teichm\"uller group GRT and can hence can be identified with the set of Drinfeld associators. [less ▲]

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See detail${\mathbb{Z}}_{2}{\times}{\mathbb{Z}}_{2}$-graded supersymmetry: 2-d sigma models
Bruce, Andrew UL

in Journal of Physics A: Mathematical and Theoretical (2020), 53(45), 455201

We propose a natural ${\mathbb{Z}}_{2}{\times}{\mathbb{Z}}_{2}$-graded generalisation of d = 2, $\mathcal{N}=\left(1,1\right)$ supersymmetry and construct a ${\mathbb{Z}}_{2}^{2}$-space realisation ... [more ▼]

We propose a natural ${\mathbb{Z}}_{2}{\times}{\mathbb{Z}}_{2}$-graded generalisation of d = 2, $\mathcal{N}=\left(1,1\right)$ supersymmetry and construct a ${\mathbb{Z}}_{2}^{2}$-space realisation thereof. Due to the grading, the supercharges close with respect to, in the classical language, a commutator rather than an anticommutator. This is then used to build classical (linear and non-linear) sigma models that exhibit this novel supersymmetry via mimicking standard superspace methods. The fields in our models are bosons, right-handed and left-handed Majorana–Weyl spinors, and exotic bosons. The bosons commute with all the fields, the spinors belong to different sectors that cross commute rather than anticommute, while the exotic boson anticommute with the spinors. As a particular example of one of the models, we present a 'double-graded' version of supersymmetric sine-Gordon theory. [less ▲]

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See detailGradient Estimates on Dirichlet and Neumann Eigenfunctions
Arnaudon, Marc; Thalmaier, Anton UL; Wang, Feng-Yu

in International Mathematics Research Notices (2020), 2020(20), 7279-7305

By methods of stochastic analysis on Riemannian manifolds, we derive explicit two-sided gradient estimates for Dirichlet eigenfunctions on a d-dimensional compact Riemannian manifold D with boundary ... [more ▼]

By methods of stochastic analysis on Riemannian manifolds, we derive explicit two-sided gradient estimates for Dirichlet eigenfunctions on a d-dimensional compact Riemannian manifold D with boundary. Corresponding two-sided gradient estimates for Neumann eigenfunctions are derived in the second part of the paper. [less ▲]

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See detailFinite deformations govern the anisotropic shear-induced area reduction of soft elastic contacts
Lengiewicz, Jakub UL; de Souza, Mariana; Lahmar, Mohamed A. et al

in Journal of the Mechanics and Physics of Solids (2020), 143

Solid contacts involving soft materials are important in mechanical engineering or biomechanics. Experimentally, such contacts have been shown to shrink significantly under shear, an effect which is ... [more ▼]

Solid contacts involving soft materials are important in mechanical engineering or biomechanics. Experimentally, such contacts have been shown to shrink significantly under shear, an effect which is usually explained using adhesion models. Here we show that quantitative agreement with recent high-load experiments can be obtained, with no adjustable parameter, using a non-adhesive model, provided that finite deformations are taken into account. Analysis of the model uncovers the basic mechanisms underlying anisotropic shear-induced area reduction, local contact lifting being the dominant one. We confirm experimentally the relevance of all those mechanisms, by tracking the shear-induced evolution of tracers inserted close to the surface of a smooth elastomer sphere in contact with a smooth glass plate. Our results suggest that finite deformations are an alternative to adhesion, when interpreting a variety of sheared contact experiments involving soft materials. [less ▲]

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See detailOdd connections on supermanifolds: existence and relation with affine connections
Bruce, Andrew UL; Grabowski, Janusz

in Journal of Physics A: Mathematical and Theoretical (2020), 53(45), 455203

The notion of an odd quasi-connection on a supermanifold, which is loosely an affine connection that carries non-zero Grassmann parity, is examined. Their torsion and curvature are defined, however, in ... [more ▼]

The notion of an odd quasi-connection on a supermanifold, which is loosely an affine connection that carries non-zero Grassmann parity, is examined. Their torsion and curvature are defined, however, in general, they are not tensors. A special class of such generalised connections, referred to as odd connections in this paper, have torsion and curvature tensors. Part of the structure is an odd involution of the tangent bundle of the supermanifold and this puts drastic restrictions on the supermanifolds that admit odd connections. In particular, they must have equal number of even and odd dimensions. Amongst other results, we show that an odd connection is defined, up to an odd tensor field of type (1, 2), by an affine connection and an odd endomorphism of the tangent bundle. Thus, the theory of odd connections and affine connections are not completely separate theories. As an example relevant to physics, it is shown that $\mathcal{N}=1$ super-Minkowski spacetime admits a natural odd connection. [less ▲]

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See detailRadio Resource Management Techniques for Multibeam Satellite Systems
Kisseleff, Steven UL; Lagunas, Eva UL; Abdu, Tedros Salih UL et al

in IEEE Communications Letters (2020)

Next–generation of satellite communication (SatCom) networks are expected to support extremely high data rates for a seamless integration into future large satellite-terrestrial networks. In view of the ... [more ▼]

Next–generation of satellite communication (SatCom) networks are expected to support extremely high data rates for a seamless integration into future large satellite-terrestrial networks. In view of the coming spectral limitations, the main challenge is to reduce the cost (satellite launch and operation) per bit, which can be achieved by enhancing the spectral efficiencies. In addition, the capability to quickly and flexibly assign radio resources according to the traffic demand distribution has become a must for future multibeam broadband satellite systems. This article presents the radio resource management problems encountered in the design of future broadband SatComs and provides a comprehensive overview of the available techniques to address such challenges. Firstly, we focus on the demand matching formulation of the power and bandwidth assignment. Secondly, we present the scheduling design in practical multibeam satellite systems. Finally, a number of future challenges and the respective open research topics are described. [less ▲]

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See detail‘You got into Oxbridge?’ Under‐represented students’ experiences of an elite university in the south of England
Stubbs, Joshua; Murphy, Emily UL

in Higher Education Quarterly (2020)

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See detailMixed-fleet single-terminal bus scheduling problem: Modelling, solution scheme and potential applications
Rinaldi, Marco UL; Picarelli, Erika UL; D'Ariano, Andrea et al

in Omega: the International Journal of Management Science (2020), 96

Reducing pollutant emissions and promoting sustainable mobility solutions, including Public Transport (PT), are increasingly becoming key objectives for policymakers worldwide. In this work we develop an ... [more ▼]

Reducing pollutant emissions and promoting sustainable mobility solutions, including Public Transport (PT), are increasingly becoming key objectives for policymakers worldwide. In this work we develop an optimal vehicle scheduling approach for next generation PT systems, considering the instance of mixed electric / hybrid fleet. Our objective is that of investigating to what extent electrification, coupled with optimal fleet management, can yield operational cost savings for PT operators. We propose a Mixed In- teger Linear Program (MILP) to address the problem of optimal scheduling of a mixed fleet of electric and hybrid / non-electric buses, coupled with an ad-hoc decomposition scheme aimed at enhancing the scalability of the proposed MILP. Two case studies arising from the PT network of the city of Luxem- bourg are employed in order to validate the model; sensitivity analysis to fleet design parameters is performed, specifically in terms of fleet size and fleet composition. Conclusions point to the fact that careful modelling and handling of mixed-fleet conditions are necessary to achieve operational savings, and that marginal savings gradually reduce as more conventional buses are replaced by their electric counterparts. We believe the methodology proposed may be a key part of advanced decision support systems for policymakers and operators that are dealing with the on-going transition from conventional bus fleets towards greener transport solutions. [less ▲]

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See detailCorona und die krisenhafte Wiederkehr des Verdrängten
Becker, Katrin UL

in Zeitschrift für Kulturphilosophie (2020), 2

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See detailJoint Bit Allocation and Hybrid Beamforming Optimization for Energy Efficient Millimeter Wave MIMO Systems
Kaushik, Aryan; Vlachos, Evangelos; Tsinos, Christos et al

in IEEE Transactions on Green Communications and Networking (2020)

In this paper, we aim to design highly energy efficient end-to-end communication for millimeter wave multiple-input multiple-output systems. This is done by jointly optimizing the digital-to-analog ... [more ▼]

In this paper, we aim to design highly energy efficient end-to-end communication for millimeter wave multiple-input multiple-output systems. This is done by jointly optimizing the digital-to-analog converter (DAC)/analog-to-digital converter (ADC) bit resolutions and hybrid beamforming matrices. The novel decomposition of the hybrid precoder and the hybrid combiner to three parts is introduced at the transmitter (TX) and the receiver (RX), respectively, representing the analog precoder/combiner matrix, the DAC/ADC bit resolution matrix and the baseband precoder/combiner matrix. The unknown matrices are computed as a solution to the matrix factorization problem where the optimal fully digital precoder or combiner is approximated by the product of these matrices. A novel and efficient solution based on the alternating direction method of multipliers is proposed to solve these problems at both the TX and the RX. The simulation results show that the proposed solution, where the DAC/ADC bit allocation is dynamic during operation, achieves higher energy efficiency when compared with existing benchmark techniques that use fixed DAC/ADC bit resolutions. [less ▲]

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See detailARCH-COMP 2020 Category Report: Falsification
Ernst, Gidon; Arcaini, Paolo; Bennani, Ismail et al

in EPiC Series in Computing (2020)

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See detailData Augmentation and Dense-LSTM for Human Activity Recognition using WiFi Signal
Zhang, Jin; Wu, Fuxiang Wu; Wei, Bo et al

in IEEE Internet of Things Journal (2020)

Recent research has devoted significant efforts on the utilization of WiFi signals to recognize various human activities. An individual’s limb motions in the WiFi coverage area could interfere wireless ... [more ▼]

Recent research has devoted significant efforts on the utilization of WiFi signals to recognize various human activities. An individual’s limb motions in the WiFi coverage area could interfere wireless signal propagation, that manifested as unique patterns for activities recognition. Existing approaches though yielding reasonable performance in certain cases, are ignorant of two major challenges. The performed activities of the individual normally have inconsistent speed in different situations and time. Besides that the wireless signal reflected by human bodies normally carry substantial information that is specific to that subject. The activity recognition model trained on a certain individual may not work well when being applied to predict another individual’s activities. Since only recording activities of limited subjects in certain speed and scale, recent works commonly have moderate amount of activity data for training the recognition model. The small-size data could often incur the overfitting issue that negative affect the traditional classification model. To address these challenges, we propose a WiFi based human activity recognition system that synthesize variant activities data through 8 CSI transformation methods to mitigate the impact of activity inconsistency and subject-specific issues, and also design a novel deep learning model that cater to the small-size WiFi activity data. We conduct extensive experiments and show synthetic data improve performance by up to 34.6% and our system achieves around 90% of accuracy with well robustness in adapting to small-size CSI data. [less ▲]

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See detailPituitary Tumor Transforming Gene 1 Orchestrates Gene Regulatory Variation in Mouse Ventral Midbrain During Aging
Gui, Yujuan UL; Thomas, Mélanie H.; Garcia, Pierre et al

in Frontiers in Genetics (2020)

Dopaminergic neurons in the midbrain are of particular interest due to their role in diseases such as Parkinson’s disease and schizophrenia. Genetic variation between individuals can affect the integrity ... [more ▼]

Dopaminergic neurons in the midbrain are of particular interest due to their role in diseases such as Parkinson’s disease and schizophrenia. Genetic variation between individuals can affect the integrity and function of dopaminergic neurons but the DNA variants and molecular cascades modulating dopaminergic neurons and other cells types of ventral midbrain remain poorly defined. Three genetically diverse inbred mouse strains – C57BL/6J, A/J, and DBA/2J – differ significantly in their genomes (∼7 million variants), motor and cognitive behavior, and susceptibility to neurotoxins. To further dissect the underlying molecular networks responsible for these variable phenotypes, we generated RNA-seq and ChIP-seq data from ventral midbrains of the 3 mouse strains. We defined 1000–1200 transcripts that are differentially expressed among them. These widespread differences may be due to altered activity or expression of upstream transcription factors. Interestingly, transcription factors were significantly underrepresented among the differentially expressed genes, and only one transcription factor, Pttg1, showed significant differences between all three strains. The changes in Pttg1 expression were accompanied by consistent alterations in histone H3 lysine 4 trimethylation at Pttg1 transcription start site. The ventral midbrain transcriptome of 3-month-old C57BL/6J congenic Pttg1–/– mutants was only modestly altered, but shifted toward that of A/J and DBA/2J in 9-month-old mice. Principle component analysis (PCA) identified the genes underlying the transcriptome shift and deconvolution of these bulk RNA-seq changes using midbrain single cell RNA-seq data suggested that the changes were occurring in several different cell types, including neurons, oligodendrocytes, and astrocytes. Taken together, our results show that Pttg1 contributes to gene regulatory variation between mouse strains and influences mouse midbrain transcriptome during aging. [less ▲]

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See detailNutrition and the 2020 Pandemic
Stover, Patrick; Balling, Rudolf UL

in Annual Review Of Nutrition (2020)

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