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See detailLa demande de proroger ou de payer une garantie autonome, observation sur l'arrêt de la chambre commerciale de la Cour de cassation, du 24 janvier 1989
Prüm, André UL; Mattout, Jean-Pierre

in La Semaine Juridique - Entreprise et Affaires (1990), II

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See detailFrom the structure to the function of villin, an actin-binding protein of the brush border.
Friederich, Evelyne UL; Pringault, E.; Arpin, M. et al

in BioEssays (1990), 12(9), 403-8

Villin, a calcium-regulated actin-binding protein, modulates the structure and assembly of actin filaments in vitro. It is organized into three domains, the first two of which are homologous. Villin is ... [more ▼]

Villin, a calcium-regulated actin-binding protein, modulates the structure and assembly of actin filaments in vitro. It is organized into three domains, the first two of which are homologous. Villin is mainly produced in epithelial cells that develop a brush border and which are responsible for nutrient uptake. Expression of the villin structural gene is precisely regulated during mouse embryogenesis and is restricted in adults, to certain epithelia of the gastrointestinal and urogenital tracts. The function of villin has been assessed by transfecting CV1 cells with a human cDNA encoding wild-type villin or mutant villin. Synthesis of large amounts of villin in cells which do not normally produce this protein induces the growth of microvilli on the cell surface and the redistribution of F-actin, concomitant with the disappearance of stress fibers. The complete villin sequence is required for the morphogenic effect. These results suggest that villin plays a key role in the morphogenesis of microvilli. [less ▲]

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See detailIncidence of juvenile type 1 (insulin dependent) diabetes mellitus in France
Levy-Marchal, C.; Papoz, L.; De Beaufort, Carine UL et al

in Diabetologia (1990), 33

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See detailCardiac baroreflex function during postural change using non-invasive spontaneous sequence analysis in young men.
Steptoe, Andrew; Vögele, Claus UL

in Cardiovascular Research (1990), 24

STUDY OBJECTIVE: The aim was to assess the value of baroreflex sensitivity estimates calculated from analyses of spontaneous systolic blood pressure and pulse interval sequences derived from continuous ... [more ▼]

STUDY OBJECTIVE: The aim was to assess the value of baroreflex sensitivity estimates calculated from analyses of spontaneous systolic blood pressure and pulse interval sequences derived from continuous non-invasive finger blood pressure recordings during sitting and active standing. DESIGN: Continuous recordings of digital systolic blood pressure and pulse interval were obtained non-invasively using a Finapres FD5 during 5 min trials of sitting and standing. SUBJECTS: Subjects were healthy males aged 19-28, divided into those with "high" normal (n = 18) and "low" normal (n = 17) blood pressure. MEASUREMENTS AND MAIN RESULTS: Recordings were scanned for spontaneous sequences of three or more cardiac cycles over which systolic blood pressure increased progressively in conjunction with prolonged pulse interval, or decreased while pulse interval became shorter. Regressions between blood pressure and pulse interval (r greater than 0.80) provided estimates of cardiac baroreceptor reflex control. Computations were carried out with concurrent blood pressure and pulse interval measurements, and with a delay or lag of one and two cycles between the two variables. Pulse interval was reduced from an average 870.3 ms sitting to 571.3 ms on standing. Mean baroreflex sensitivity while sitting averaged 17.5 ms.mm Hg-1 at a delay of one cycle, failing to 7.65 ms.mm Hg-1 with standing. The decrease in sensitivity was correlated with the change in pulse interval between trials. The number of sequences was also significantly reduced with standing as opposed to sitting. Three cycle sequences were most frequent, with a lesser number of sequences involving 4, 5, and 6 or more cycles. No significant differences between "high" and "low" normal blood pressure groups were observed. CONCLUSIONS: The analysis of spontaneous sequences from non-invasive recordings may provide useful information concerning cardiac baroreflex control in different postural and behavioural states. A lag of one cycle between systolic blood pressure and pulse interval may provide the most representative estimates of baroreflex sensitivity. [less ▲]

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See detailLes groupes exponentiels. Deuxième partie
Molitor-Braun, Carine UL

in Travaux Mathématiques (1990), 2

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See detailNeuropeptides and inflammation: presumed mechanisms in neurogenic inflammation
Landry, Y.; Bloch, J. G.; Mousli, M. et al

in Pathologie et Biologie (1990), 38(1), 53-6

Neuropeptides, among which substance P, VIP (Vasoactive intestinal peptide), somatostatin, neurotensin, dynorphin and enkephalins, are able to modulate inflammatory processes. Increasing interest is now ... [more ▼]

Neuropeptides, among which substance P, VIP (Vasoactive intestinal peptide), somatostatin, neurotensin, dynorphin and enkephalins, are able to modulate inflammatory processes. Increasing interest is now devoted to these peptides in different inflammatory diseases, concerning skin, lung and joins. The effect of substance P can be dependent on its C-terminal moiety implicating by this way an interaction with specific neurokinin receptors or can be dependent on its N-terminal moiety which does not involve a specific membrane receptor. Such diversity of the action mechanisms of peptides should influence the evolution of the anti-inflammatory therapeutic. [less ▲]

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See detailOntwikkelingen in het Amerikaanse theoretisch-pedagogishe debat.
Biesta, Gert UL; Miedema, S.

in Pedagogische Studiën: Tijdschrift voor Onderwijskunde en Opvoedkunde (1990), 67

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See detailUsing Concordances in the Classroom
Weber, Jean-Jacques UL

in Bulletin Nouvelles Technologies et Education (1990), 6

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See detailAnalysis of the spatial and temporal control of Hox 1.1 in transgenic mice
Püschel, A; Balling, Rudi UL; Gruss, P

in Development (1990), (108), 435-442

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See detailVillin induces microvilli growth and actin redistribution in transfected fibroblasts.
Friederich, Evelyne UL; Huet, C.; Arpin, M. et al

in Cell (1989), 59(3), 461-75

The function of villin, an actin-binding protein, has been investigated by transfecting fibroblasts with cloned human cDNAs encoding wild-type villin or functional villin domains. Synthesis of large ... [more ▼]

The function of villin, an actin-binding protein, has been investigated by transfecting fibroblasts with cloned human cDNAs encoding wild-type villin or functional villin domains. Synthesis of large amounts of villin induced the growth of numerous long microvilli on cell surfaces together with the redistribution of F-actin. These microvilli contained a cytoskeleton of F-actin, and their appearance was frequently accompanied by the disappearance of stress fibers. The complete villin gene sequence was required to exert its morphogenic effect. Villin lacking one actin-binding domain (113 amino acids), located at its carboxyterminal end, did not induce growth if microvilli or stress fiber disruption. Our results indicate that villin plays a key role in vivo in the morphogenesis of microvilli. [less ▲]

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See detail[Increased atrial natriuretic peptide in essential hypertension--relation to right atrial pressure behavior].
Neyses, Ludwig UL; Nitsch, J.; Tuttenberg, H. P. et al

in Klinische Wochenschrift (1989), 67(15), 756-61

The role of atrial natriuretic peptide (ANP) in the pathogenesis of essential hypertension has not yet entirely been clarified. We investigated whether the increase of ANP in essential hypertension may be ... [more ▼]

The role of atrial natriuretic peptide (ANP) in the pathogenesis of essential hypertension has not yet entirely been clarified. We investigated whether the increase of ANP in essential hypertension may be explained by elevated right atrial pressures and/or a different relationship between right atrial pressures and ANP secretion. Patients with stable essential hypertension undergoing right and left heart catheterization because of suspected coronary heart disease had significantly higher ANP levels than normotensives: 58.7 +/- 6.7 pg/ml in hypertensives versus 42.0 +/- 4.1 pg/ml in normotensives (p less than 0.01). Matching hypertensives with normotensives at identical levels of left ventricular enddiastolic pressure revealed significantly higher mean pulmonary artery pressures in hypertensives. Right atrial diastolic pressure (v-wave) after matching for LVEDP was 4.8 +/- 0.5 mm Hg in hypertensives and 3.1 +/- 0.2 mm Hg in normotensives (p less than 0.05). In addition, at any given mean right atrial pressure hypertensives showed higher ANP levels than normotensives. These results demonstrate that hypertensives exhibit raised pressures in the pulmonary artery independent of left ventricular pressure load. The elevation in right atrial pressures and the steeper relationship between these pressures and ANP are a suitable explanation for raised ANP levels in hypertension. ANP in essential hypertension may represent a counterregulation against elevated pulmonary resistance. [less ▲]

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See detailCraniofacial abnormalities induced by ectopic expression of the homeobox gene Hox-1.1 in transgenic mice.
Balling, Rudi UL; Mutter, G.; Gruss, P. et al

in Cell (1989), 58(2), 337-47

Hox-1.1 is a murine homeobox-containing gene expressed in a time- and cell-specific manner during embryogenesis. We have generated transgenic mice that ectopically express Hox-1.1 from the chicken beta ... [more ▼]

Hox-1.1 is a murine homeobox-containing gene expressed in a time- and cell-specific manner during embryogenesis. We have generated transgenic mice that ectopically express Hox-1.1 from the chicken beta-actin promoter. In these mice Hox-1.1 expression was changed to an almost ubiquitous pattern. Ectopic expression of Hox-1.1 leads to death of the transgenic animals shortly after birth and is associated with multiple craniofacial anomalies, such as cleft palate, open eyes at birth, and nonfused pinnae. This phenotype is similar to the effects seen after systemic administration of retinoic acid during gestation. This suggests that retinoic acid embryopathy and the specific developmental defects caused by ectopic expression of a potential developmental control gene share a common pathogenic mechanism. [less ▲]

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See detailDer Fragebogen zur Erfassung gesundheitsbezogener Kontrollüberzeugungen (FEGK). Kurzbericht.
Ferring, Dieter UL; Filipp, Sigrun-Heide

in Zeitschrift für Klinische Psychologie, Psychopathologie und Psychotherapie (1989), 18(3)

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See detailActivation of rat peritoneal mast cells by substance P and mastoparan
Mousli, M.; Bronner, C.; Bueb, Jean-Luc UL et al

in Journal of Pharmacology and Experimental Therapeutics (1989), 250(1), 329-35

Incubation of rat peritoneal mast cells with substance P resulted in the transient stimulation of phosphoinositol breakdown and histamine secretion through an exocytotic process. These effects were ... [more ▼]

Incubation of rat peritoneal mast cells with substance P resulted in the transient stimulation of phosphoinositol breakdown and histamine secretion through an exocytotic process. These effects were inhibited markedly by a prior 2-hr exposure of the cells to pertussis toxin. Pertussis toxin also inhibited exocytosis induced by substance P, mastoparan and compound 48/80, but did not modify the secretory effect of the ionophore A23187. The transfer of rat peritoneal mast cells from balanced salt solution to calcium-free buffer led to a similar time-dependent decrease in their response to substance P and mastoparan. The concomitant absence of potassium from the calcium-free buffer enabled the mast cells to retain their secretory response. These data demonstrate identical dependency for calcium and monovalent ions of the secretory process elicited by substance P, mastoparan and compound 48/80. Pretreatment of mast cells with neuraminidase decreased the secretagogic effect of substance P, mastoparan and compound 48/80 without modifying the efficiency of the ionophore A23187. Thus, sialic acid residues might be involved in the initial binding of peptides and compound 48/80 to mast cells, which activate a pertussis toxin-sensitive G-protein and allows the increase in phospholipase C activity to induce exocytosis. This sequence of events might characterize the physiological pathway of mast cell activation by peptides, without necessarily requiring selective membrane receptors. [less ▲]

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See detailSEBV – Skala zur Erfassung des Bewältigungsverhaltens (Fragebogen zur Krankheitsverarbeitung; WOC). Test Info.
Ferring, Dieter UL; Filipp, Sigrun-Heide

in Zeitschrift für Differentielle und Diagnostische Psychologie (1989), 10(4)

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See detailSpinal lamina I projection neurons in the rat: collateral innervation of parabrachial area and thalamus
Hylden, Janice LK; Anton, Fernand UL; Nahin, Richard L

in Neuroscience (1989), 28(1), 27-37

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See detailContractile activity of the N-acylated C-terminal part of substance P7-11 in guinea pig trachea. Effect of epithelium removal
Tschirhart, Eric UL; Schmitt, P.; Bertrand, C. et al

in Naunyn-Schmiedeberg's Archives of Pharmacology (1989), 340(1), 107-10

Substance P, neurokinin A, neurokinin B, and N-acylated pentapeptide X-Phe-Phe-Gly-Leu-Met-NH2 analogs of substance P7-11 were tested for their spasmogenic activities in intact or in epithelium-denuded ... [more ▼]

Substance P, neurokinin A, neurokinin B, and N-acylated pentapeptide X-Phe-Phe-Gly-Leu-Met-NH2 analogs of substance P7-11 were tested for their spasmogenic activities in intact or in epithelium-denuded tracheal strips from guinea pig. Epithelium removal enhanced the efficacies and potencies relative to substance P of all the peptides tested in guinea pig trachea. In epithelium-containing preparations, the presence of a cyclic substituent (o-hydroxyphenyl-acetyl, p-hydroxyphenyl-acetyl, pyroglutamyl) in Phe7 greatly enhanced the potency and efficacy compared to substance P. These substitutions were twice as active as neurokinin A itself. The presence of an aliphatic chain (non-protected and t-butyloxycarbonyl-protected aminopropyl and aminocaproyl) in Phe7 also improved the potency and the efficacy of the synthetic peptides. The aliphatic substituents could favour an increase in local concentration of the peptides in the vicinity of the receptor(s) allowing a more effective ligand-receptor interaction. Thus, lipophilicity could be determinant in the potency of the peptides in intact guinea pig trachea. In epithelium-denuded tracheal strips from guinea pig, all the synthetic peptides were more effective than substance P but less active than neurokinin A which probably reflects the presence of the NK2 receptor subtype, which may be predominant in this type of epithelium-denuded preparation. Our results suggest that hydrophobicity plays a strong role in the interaction of the peptides, namely substance P and its analogues with the membrane and possibly the receptors themselves. [less ▲]

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See detailGaInAs Camel Transistors Grown by MOCVD
Marso, Michel UL; Zwinge, G.; Beneking, H.

in Electronics Letters (1989), 25(1989), 1462-1463

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See detailLes groupes exponentiels
Molitor-Braun, Carine UL

in Travaux Mathématiques (1989), 1

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See detailDer Dollar als internationale Schlüsselwährung: Ursachen und Perspektiven
Klump, Rainer UL

in Kredit und Kapital (1989)

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See detailGegenstandsverständnis und Zielsetzungen kognitiver Ansätze zur Analyse spezifischer Emotionen. Anmerkungen zum Komponentenprozeß- Modell von K. R. Scherer
Boll, Thomas UL; Neppl, Rainer

in Sprache und Kognition (1989), 8(1), 9-18

Uses the example of K. R. Scherer's component process model to critically discuss the theoretical and epistemological problems in cognitive approaches to the analysis of specific emotions. First, a ... [more ▼]

Uses the example of K. R. Scherer's component process model to critically discuss the theoretical and epistemological problems in cognitive approaches to the analysis of specific emotions. First, a syndromatic understanding of emotions is discussed in which expressive and physiological patterns of reactions as well as perceptions are regarded as necessary components of a specific emotion. Then three of the goals of cognitive approaches named by Scherer are discussed: (1) the scientific conceptualization of specific emotions, (2) the analysis of the semantics of emotion terms, and (3) the causal analysis of specific emotions. In contrast to Scherer's concept, an explicit analysis of natural-language emotion terms is considered to be an essential basis for the scientific conceptualization of specific emotions. The latter is seen as a requirement for differntiating between empirical and pseudoempirical research. [less ▲]

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See detailReview of: M. Toolan. Narrative
Weber, Jean-Jacques UL

in Journal of Literary Semantics (1989), 18

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See detailDistribution of substance P and calcitonin gene-related peptide in articular afferent neurons
Hanesch, Ulrike UL; Heppelmann, Bernd; Schmidt, Robert

in Supplement ... to the European Journal of Neuroscience (1989), (Suppl. 2), 69

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See detail«La sindrome dell'eco-lalia»
Roelens, Nathalie UL

in Restant (1989)

Detailed reference viewed: 67 (1 UL)
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See detail«Palomar, palombaro perplesso»
Roelens, Nathalie UL

in Gruppo di Contatto "Italianistica" (1989)

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See detailLes droits en France du créateur d'information
Prüm, André UL; Le Stanc, Christian

in Revue Internationale de Droit Economique (1989)

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See detailOctamer binding proteins confer transcriptional activity in early mouse embryogenesis.
Scholer, H. R.; Balling, Rudi UL; Hatzopoulos, A. K. et al

in EMBO Journal (1989), 8(9), 2551-7

Oct4 and Oct5 are two mouse maternally expressed proteins binding to the octamer motif. Both are found in unfertilized oocytes and embryonic stem cells, whereas Oct4 is also found in primordial germ cells ... [more ▼]

Oct4 and Oct5 are two mouse maternally expressed proteins binding to the octamer motif. Both are found in unfertilized oocytes and embryonic stem cells, whereas Oct4 is also found in primordial germ cells. In this study, the activity of the octamer motif was analysed in two embryonic stem cell lines containing Oct4 and Oct5, the teratocarcinoma-derived cell line F9 and the blastocyst-derived cell line D3. It is known that oligomerization of the octamer motif creates a powerful B-cell specific enhancer. As shown here, this oligomerized transcriptional element is also a very strong enhancer in F9 and D3 embryonic stem cells. After differentiation of the stem cells, both enhancer activity and the amount of the octamer binding proteins decrease. An intact octamer stimulates heterologous promoters in embryonic stem cells, whereas mutations in the octamer motif abolish transcriptional stimulation and binding of the octamer factors. The use of transgenic embryos demonstrates transcriptional activation in the inner cell mass but not in the trophoblast of blastocysts. The results indicate that Oct4 and Oct5 are active early in mouse development. [less ▲]

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See detailThe detection and perveived intensity of noxious thermal stimuli in monkey and human
Kenshalo, Dan R; Anton, Fernand UL; Dubner, Ronald

in Journal of Neurophysiology (1989), 62(2), 429-436

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See detailBlood-retinal and blood-aqueous barrier permeability, lens autofluorescence and transmission in insulin-dependent diabetic youngsters
Van Wirdum, E.; van Best, J.; Bruining, G.J. et al

in Graefe's Archive of Clinical & Experimental Ophthalmology (1989), 227(1), 26-19

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See detailVerslag AERA-congres 1989 te San Francisco. Divisie F: History and historiography.
Biesta, Gert UL; Miedema, S.

in Pedagogische Studiën: Tijdschrift voor Onderwijskunde en Opvoedkunde (1989), 66

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See detailContinuous subcutaneous insulin infusion (CSII) versus conventional insulin injection therapy in newly diagnosed diabetic children : a randomised prospective trial
De Beaufort, Carine UL; Houtzagers, C.M.G.J.; Bruining, G.J. et al

in Diabetic Medicine: A Journal of the British Diabetic Association (1989), 6

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See detailPeripheral nerve function in children with end-stage renal failure
De Beaufort, Carine UL; André, J.-L.; Heimans, J. J. et al

in Pediatric Nephrology (1989), 3(2), 175-178

Information on clinical and subclinical peripheral neuropathy in children with end-stage renal failure (ESRF) is scarce. We have studied the presence of clinical and subclinical peripheral neuropathy in ... [more ▼]

Information on clinical and subclinical peripheral neuropathy in children with end-stage renal failure (ESRF) is scarce. We have studied the presence of clinical and subclinical peripheral neuropathy in children with ESRF comparing recently developed non-invasive methods with the measurement of nerve conduction velocities. Twelve children (7 boys, 5 girls; age range: 5-17 years; duration of haemodialysis: 0.5-60 months) participated. Thermal discrimination threshold (TDT) and vibration perception threshold (VPT) were determined twice before and after haemodialysis in each patient. Peroneal nerve conduction velocity was determined once before haemodialysis. No clinical or subclinical peripheral neuropathy was observed in any of the children. Except for two slightly increased TDT values after haemodialysis all results were within the normal range. No correlation was found with age or duration of haemodialysis and no association was found between the three methods. VPT values showed a significant improvement after haemodialysis treatment, although all VPT values were in the normal range. This suggests that haemodialysis has an influence on cutaneous sensation, but further study is needed to confirm this observation. Longitudinal investigations will be necessary to evaluate whether TDT and VPT determinations can be used for early screening of clinical and subclinical neuropathy in children with ESRF. © 1989 IPNA. [less ▲]

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See detailImpaired relaxation of the hypertrophied myocardium is potentiated by angiotensin II.
Neyses, Ludwig UL; Vetter, H.

in Journal of Hypertension. Supplement) (1989), 7(6), 104-5

Relaxation delay is an important feature of hypertensive heart disease which impairs diastolic coronary flow and ventricular filling and therefore contributes to heart failure. We investigated the ... [more ▼]

Relaxation delay is an important feature of hypertensive heart disease which impairs diastolic coronary flow and ventricular filling and therefore contributes to heart failure. We investigated the hypothesis that impaired relaxation is a property of the myocardium, rather than the consequence of ischaemia or interstitial fibrosis. A new videomicroscope system was used to define the contraction-relaxation cycle of isolated cardiac myocytes from spontaneously hypertensive rats (SHR) and normotensive control (Wistar-Kyoto, WKY) rats. The SHR cells showed a marked relaxation delay. Angiotensin II (Ang II) increased the contraction maximum by about 35% in WKY rats and induced a relaxation delay. In SHR Ang II greatly potentiated this relaxation delay. Our results demonstrate that impairment of relaxation is a property of the single cardiomyocyte. Angiotensin II induces a relaxation delay that is independent of blood pressure. The combination of hypertrophy and high levels of Ang II potentiates relaxation impairment and may therefore contribute to hypertensive left ventricular failure. [less ▲]

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See detailReview of: D. Birch. Language, Literature and Critical Practice
Weber, Jean-Jacques UL

in Journal of Literary Semantics (1989), 18

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See detailMethodisch Handelen in Beroep en Opleiding.
Biesta, Gert UL

in Gamma. (1989), 39(4), 102-105

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See detailStructure, expression and chromosomal localization of Zfp-1, a murine zinc finger protein gene.
Chowdhury, K.; Dietrich, S.; Balling, Rudi UL et al

in Nucleic Acids Research (1989), 17(24), 10427-38

Zinc finger proteins (Zfp) are encoded by a large family of genes present in many organisms including yeast and human. Some of them are transcriptional activators and bind specifically to DNA by zinc ... [more ▼]

Zinc finger proteins (Zfp) are encoded by a large family of genes present in many organisms including yeast and human. Some of them are transcriptional activators and bind specifically to DNA by zinc mediated folded structures commonly known as zinc fingers. The Drosophila Kruppel (Kr) is a segmentation gene and encodes a zinc finger protein. Using a probe from the finger domain of Kr, we have isolated a structurally related gene Zfp-1 from the mouse. In this paper, we report the complete nucleotide sequence of two cDNA clones and the amino acid sequence deduced from them. The putative Zfp-1 protein contains in addition to 7 zinc fingers, two helix-turn-helix motifs. During murine embryogenesis, the Zfp-1 was found to express at a peak level in day 12 embryos. The ubiquitously expressed Zfp-1 gene is located in the 16q region on mouse chromosome 8, between the uvomorulin and the tyrosine amino transferase genes. [less ▲]

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See detailVygotskij in Harlem: The Barbara Taylor School.
Biesta, Gert UL; Miedema, S.

in Jeugd en samenleving : maandblad (1989), 19(9), 547-562

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See detailAction of atrial natriuretic peptide and angiotensin II on the myocardium: studies in isolated rat ventricular cardiomyocytes.
Neyses, Ludwig UL; Vetter, H.

in Biochemical and biophysical research communications (1989), 163(3), 1435-43

Isolated calcium-tolerant rat ventricular cardiomyocytes were used to characterize the effects of atrial natriuretic peptide (ANP), Angiotensin II (AII) and their interaction on the myocardial contraction ... [more ▼]

Isolated calcium-tolerant rat ventricular cardiomyocytes were used to characterize the effects of atrial natriuretic peptide (ANP), Angiotensin II (AII) and their interaction on the myocardial contraction-/relaxation pattern free of interference from other types of cardiac cells. Binding of 125I-ANP showed a KD of 12 pM and approximately 600 binding sites per cell. At 37 degrees C (rate 140 bpm) ANP decreased the contraction maximum with an EC50 of about 70 pM, maximal decrease was 35%. ANP (10(-7) M) raised cellular cyclic-GMP from 0.76+/-0.12 to 1.32+/-0.13 pmole/10(6) cells (73%, p less than 0.05). Angiotensin II increased contractility by a maximum of 32% at 10(-7) M; the EC50 was 8 x 10(-10) M. AII markedly delayed relaxation (reduction of maximum relaxation velocity from 0.092 to 0.063 mm/s; p less than 0.05). ANP (10(-7) M) increased the effect of AII (10(-8) M) on contractility by 66% without changing relaxation parameters significantly. This unexpected interaction may be relevant in pathological conditions where both AII and ANP are stimulated, such as heart failure or secondary hypertension. [less ▲]

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See detailNedocromil sodium inhibits IgE- and IgG-related antigen-induced contraction in guinea-pig trachea
Bertrand, C.; Tschirhart, Eric UL; Landry, Y.

in International Archives of Allergy and Applied Immunology (1989), 88(4), 439-46

The effects of nedrocromil sodium and disodium cromoglycate were studied on the anaphylactic contraction of guinea-pig trachea in two models of active sensitization (IgE and IgG models). The influence of ... [more ▼]

The effects of nedrocromil sodium and disodium cromoglycate were studied on the anaphylactic contraction of guinea-pig trachea in two models of active sensitization (IgE and IgG models). The influence of epithelial removal on the effects of nedocromil sodium and disodium cromoglycate was examined because several studies have shown that the epithelial layer can modulate agonist- or antigen-induced contractile responses. Disodium cromoglycate (10(-4) M) and nedocromil sodium (10(-4) M) provided significant protection against antigen-induced contractions of guinea-pig tracheal smooth muscle in the IgG model. But only nedocromil sodium had an effect at this concentration in the IgG model and was also effective at 10(-5) M in the epithelium-denuded tracheal strips. At this concentration, disodium cromoglycate lost its protective effect. Comparison with the results obtained with FPL-55712, AA-861 and mepyramine suggested that these drugs affect histamine and particularly leukotriene synthesis and/or release by mast cells or other immunocompetent cells. These findings indicate that nedocromil sodium inhibits the IgE- and IgG-related antigen-induced contraction in guinea-pig airways, whereas disodium cromoglycate inhibits only the IgG-related processes. This study supports the hypothesis that these drugs modulate antigen-induced mediator synthesis and/or release from immunocompetent cells. [less ▲]

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See detailZur Alters- und Bereichsspezifität subjektiven Alterserlebens.
Filipp, Sigrun-Heide; Ferring, Dieter UL

in Zeitschrift für Entwicklungspsychologie und Padagogische Psychologie (1989), 21(4)

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See detailImplizites und explizites Gedächtnis beim Bearbeiten visueller Vorstellungen.
Wippich, Werner; Mecklenbräuker, Silvia; Wachtl, U. et al

in Sprache und Kognition (1989), 8(2), 51-64

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See detailTranscriptional activity of the octamer motif in embryonic stem cells and preimplantation embryos
Schöler, H. R.; Balling, Rudi UL; Hatzopoulos, A. K. et al

in Hormones and Cell Regulation (1989), 198(14), 91-95

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See detailNeuronal architecture of the central complex in Drosophila melanogaster
Hanesch, Ulrike UL; Fischbach, Karl-Friedrich; Heisenberg, Martin

in Cell and Tissue Research (1989), 257

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See detailBewältigung kritischer Lebensereignisse: Erste Erfahrungen mit einer Version der „Ways of Coping Checklist“.
Ferring, Dieter UL; Filipp, Sigrun-Heide

in Zeitschrift für Differentielle und Diagnostische Psychologie (1989), 10(4)

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See detailDer Wal ist kein Fisch, und doch ist er ein „Walfisch“. Antwort auf die Essenz der Emotionen: Bedeutungskonstituenten der Alltagssprache oder multikomponentiale Verlaufsmuster?
Boll, Thomas UL; Neppl, Rainer

in Sprache und Kognition (1989), 8

Discusses some of the points raised in K. Scherer's reply to the authors' criticism of his component process model of the emotions (both in Sprache & Kognition 1989, 8 (1)). The first point considered is ... [more ▼]

Discusses some of the points raised in K. Scherer's reply to the authors' criticism of his component process model of the emotions (both in Sprache & Kognition 1989, 8 (1)). The first point considered is Scherer's doubts about the hypothesis that the explication of the semantic structures of the words used to describe emotions in everyday language forms the precondition for scientific concept formation and empirical research into specific emotions in psychology. Then his doubts about the possibility of implementing a standardized language analysis in this context are considered. He justifies these doubts by pointing to the interindividual differences in the use of words describing emotions. Finally, a reply is given to his doubts about the implications of using language analysis for psychological research on specific emotions in different language communities and cultures. [less ▲]

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See detailA family of octamer-specific proteins present during mouse embryogenesis: evidence for germline-specific expression of an Oct factor.
Scholer, H. R.; Hatzopoulos, A. K.; Balling, Rudi UL et al

in EMBO Journal (1989), 8(9), 2543-50

We have analysed various adult organs and different developmental stages of mouse embryos for the presence of octamer-binding proteins. A variety of new octamer-binding proteins were identified in ... [more ▼]

We have analysed various adult organs and different developmental stages of mouse embryos for the presence of octamer-binding proteins. A variety of new octamer-binding proteins were identified in addition to the previously described Oct1 and Oct2. Oct1 is ubiquitously present in murine tissues, in agreement with cell culture data. Although Oct2 has been described as a B-cell-specific protein, similar complexes were also found with extracts from brain, kidney, embryo and sperm. In embryo and brain at least two other proteins, Oct3 and Oct7, are present. A new microextraction procedure allowed the detection of two maternally expressed octamer-binding proteins, Oct4 and Oct5. Both proteins are present in unfertilized oocytes and embryonic stem cells, the latter containing an additional protein, Oct6. Whereas Oct4 was not found in sperm or testis, it is expressed in male and female primordial germ cells. Therefore Oct4 expression is specific for the female germline at later stages of germ cell development. Our results indicate that a family of octamer-binding proteins is present during mouse development and is differentially expressed during early embryogenesis. Protease clipping experiments of Oct4 and Oct1 suggest that both proteins contain similar DNA-binding domains. [less ▲]

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See detailDie Zahl der aktiven palmaren Schweißdrüsen (PSI, palmar sweat index) als psychophysiologischer Parameter.
Köhler, Thomas; Vögele, Claus UL; Weber, Dittmar

in Zeitschrift für Experimentelle und Angewandte Psychologie (1989), 36

Two laboratory studies were carried out to assess the behavior of the active palmar sweat glands in both an active and a passive coping situation. Stressor in study I was watching a distressing film, in ... [more ▼]

Two laboratory studies were carried out to assess the behavior of the active palmar sweat glands in both an active and a passive coping situation. Stressor in study I was watching a distressing film, in study II mental arithmetic. Subjects were male students, 17 in experiment I, 20 in experiment II. Both experiments involved a 10-minute baseline phase, a 10-minute stress period, and a follow-up of 10 minutes. PSI was assessed at 90-sec intervals and averaged across phases, as were readings in SCL, SCR, heart rate, diastolic and systolic blood pressure. PSI could be determined in 16 subjects of each study. In both experiments PSI increased significantly from baseline to stress (p less than 0.1%) and decreased from stress to follow-up (p less than 0.1%), and thus proved to be the most sensitive indicator for stress. The interrater reliability for counting the number of active sweat glands was high when the area for evaluation was defined unambiguously. Since the assessment of the PSI does not require a sophisticated technology and is thus also applicable in field research, we suggest giving more consideration to this variable. [less ▲]

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See detailLangeveld en Dewey: Reconstructie en poging tot bemiddeling.
Miedema, S.; Biesta, Gert UL

in Pedagogisch Tijdschrift: Forum voor Opvoedkunde (1989)

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See detailMurine Genes with homology to Drosophila segmentation genes.
Dressler, G. R.; Deutsch, U; Balling, Rudi UL et al

in Development (1988), 0(104), 181-186

Detailed reference viewed: 74 (2 UL)
See detailVerslag van het AERA-Congres 1988 te New Orleans: The John Dewey Society.
Biesta, Gert UL

in Pedagogische Studiën: Tijdschrift voor Onderwijskunde en Opvoedkunde (1988), 65(11), 453-454

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See detailAffektiv-motivationale Korrelate von Formen der Krankheitsbewältigung. Erste Ergebnisse einer Längsschnittstudie mit Krebspatienten.
Filipp, Sigrun-Heide; Ferring, Dieter UL; Freudenberg, Elke et al

in Psychotherapie, Psychosomatik, Medizinische Psychologie (1988), 38(1)

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See detailAuslösung und Dämpfung von Feindseligkeit
Montada, Leo UL; Boll, Thomas UL

in Untersuchungen des Psychologischen Dienstes der Bundeswehr (1988), 23

Auf der Basis einer kognitionspsychologischen Analyse verschiedener aggressionsbezogener Gefühle (Wut, Ärger, Hass, Neid, Empörung) werden bei Wehrpflichtigen Bedingungen der Entstehung und Dämpfung von ... [more ▼]

Auf der Basis einer kognitionspsychologischen Analyse verschiedener aggressionsbezogener Gefühle (Wut, Ärger, Hass, Neid, Empörung) werden bei Wehrpflichtigen Bedingungen der Entstehung und Dämpfung von Feindseligkeit im Sinne von Hass gegenüber einem Vorgesetzten untersucht. Drei Indikatoren der Feindseligkeit wurden erhoben: (1) positive Gefühle bei einer Schädigung des Vorgesetzten, (2) Häufigkeit unwillkürlich interferierender Schädigungsvorstellungen und (3) negative Bewertung des Vorgesetzten. Feindseligkeit wurde im Wesentlichen als Funktion von fünf Variablen erwartet: (1) erlebte Beeinträchtigung durch den Vorgesetzten, (2) wahrgenommene Absichtlichkeit der Beeinträchtigung, (3) wahrgenommene Machtlosigkeit gegenüber dem Vorgesetzten, (4) Ablehnung von Rechtfertigungsgründen für das Handeln des Vorgesetzten und (5) Widerstandswille gegenüber diesem. Dämpfende Effekte auf Feindseligkeit sollten erlebte Sicherheit in sozialen Kontexten haben (Selbstvertrauen, wahrgenommene Unterstützung durch Kameraden oder höhere Vorgesetzte, Gerechtigkeit in der eigenen Einheit) sowie positive Bewertung der Bundeswehr und der Wehrpflicht. Alle Variablen wurden mit eigens konstruierten Fragebogen an einer Untersuchungsstichprobe von 426 Soldaten aus fünf Ausbildungsquartalen und unterschiedlich "harten" Einheiten erhoben. Wesentliche Ergebnisse waren: Die Kernvariablen wirkten in erwarteter Richtung auf Feindseligkeit. Die Indikatoren für erlebte Sicherheit wirkten insgesamt erwartungsgemäß dämpfend auf Feindseligkeit, was die direkten linearen Effekte anbelangt. Die Moderatoreffekte von Sicherheitsvariablen auf die Beziehung zwischen erlebter Beeinträchtigung und Feindseligkeit waren größtenteils erwartungswidrig: je höher die Sicherheit, um so grösser die Effekte erlebter Beeinträchtigung auf Feindseligkeit. Die Validität der Feindseligkeitsmaße wird diskutiert, und praktische Schlussfolgerungen, die die Vermeidung oder Dämpfung von Feindseligkeit betreffen, werden gezogen. [less ▲]

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See detailSI nociceptive neurons participate in the encoding proces by which monkeys perceive the intnesity of noxious thermal stimulation
Kenshalo, Dan R; Chudler, Eric H; Anton, Fernand UL et al

in Brain Research (1988), 454(1-2), 378-382

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See detail[Concentrations of amiodarone and flecainide in plasma and saliva--indications for the active transport of flecainide].
Nitsch, J.; Kohler, U.; Neyses, Ludwig UL et al

in Zeitschrift fur Kardiologie (1988), 77(2), 99-102

Only the free protein-unbound drug concentration in plasma is pharmacologically active. The concentration of some drugs in saliva is equal to the free drug level. We compared concentrations (in plasma ... [more ▼]

Only the free protein-unbound drug concentration in plasma is pharmacologically active. The concentration of some drugs in saliva is equal to the free drug level. We compared concentrations (in plasma before, 30 and 60 min after the morning dose, in saliva before, 30, 60, 90 and 120 min after the morning dose) of amiodarone (n = 8, 2 x 200 mg orally per day) and flecainide (n = 16, 2 x 100 mg) administered as chronic antiarrhythmic treatment. Drug levels were measured by "high performance liquid chromatography". Results: Just prior to the first morning dose, amiodarone concentrations in plasma were 1.0-2.9 (2.0 +/- 0.6) micrograms/ml, in saliva 0.02-0.25 micrograms/ml; flecainide in plasma 80-560 (316 +/- 163) ng/ml, in saliva 630-3700 (1749 +/- 963) ng/ml. After the morning dose we found maximal flecainide plasma levels of 462 +/- 203 and saliva levels of 3218 +/- 2857 ng/ml. The highest flecainide concentrations in the saliva (13,400 and 11,300 ng/ml) were found in two patients 30 and 60 min after the morning dose. Flecainide, but not amiodarone, is excreted actively in the saliva, probably indicating an enteroenteric circulation. This should be considered to reduce life-threatening flecainide intoxications by gastric and intestinal lavage and suction. The concentration of flecainide in the saliva does not represent the non-protein-bound free drug level in the plasma. [less ▲]

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See detailLa détermination du prix dans les contrats commerciaux portant vente de marchandises - Réflexions comparatives
Corbisier, Isabelle UL

in Revue Internationale de Droit Comparé (1988), 40(4), 767-831

La question de la détermination du prix dans la vente se rattache dans de nombreux systèmes juridiques (nous envisageons ici les droits français, belge, anglais, américain et louisianais) au principe de l ... [more ▼]

La question de la détermination du prix dans la vente se rattache dans de nombreux systèmes juridiques (nous envisageons ici les droits français, belge, anglais, américain et louisianais) au principe de l'autonomie de la volonté « principle of freedom of contract ». Cette étude démontre que l'application de ce principe doit être infléchie, voire même remise en question, dans un contexte contemporain de relations commerciales dont la complexité et la durée appellent une approche plus flexible. Nous verrons dans quelle mesure ce résultat a été atteint sur les plans tant nationaux qu'international. Une utilisation plus généralisée de certains standards devrait résulter en une plus grande uniformisation de conceptions dont la diversité est finalement moins grande qu'il n'y paraît. TEXTE INTEGRAL DE L'ARTICLE SOUS LE LIEN INTERNET INDIQUE Ci-DESSOUS [less ▲]

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See detailZur strukturellen Repräsentation alltagssprachlicher Person- und Verhaltensbeschreibungen
Krolak-Schwerdt, Sabine UL

in Zeitschrift für Sozialpsychologie (1988), 19

The present paper is focused on the topic of a structural representation of adjectives describing interpersonal behavior in ordinary Janguage. 40 students of the University of Saarland were presented 117 ... [more ▼]

The present paper is focused on the topic of a structural representation of adjectives describing interpersonal behavior in ordinary Janguage. 40 students of the University of Saarland were presented 117 adjectives selected on the basis of studies in the domain of verbal behavior descriptions by considering the concept of frequency of use. Subjects were asked to partition this set of adjectives into groups under the aspect of similarity of meaning. In order to analyse the relations between the investigated words and to provide a representation of all relevant relations simultaneously, the data of the sorting-task were inspected by hierarchical dustering and multidimensional scaling techniques. Thus a dimensional configuration reflecting inter-dass-relations was obtained and various dustering methods generated concordant dasses of adjectives which appeared to be interpretable at two different Ievels of analysis. [less ▲]

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See detailDewey's Logic: A Reconstructive View on the Relation between Theory and Practice.
Biesta, Gert UL; Miedema, S.

in Insights (1988), 24(1), 6-7

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See detailThe incidence of Type 1 (insulin-dependent) diabetes mellitus in subjects aged 0-19 years in Luxembourg: a retrospective study from 1977 to 1986
De Beaufort, Carine UL; Michel, G.; Glaesener, G.

in Diabetologia (1988), 31(10), 758-761

A decrease in the incidence of Type 1 (insulin-dependent) diabetes mellitus in the age group 0-14 years has been observed from north to south over north-western Europe. To evaluate whether this trend ... [more ▼]

A decrease in the incidence of Type 1 (insulin-dependent) diabetes mellitus in the age group 0-14 years has been observed from north to south over north-western Europe. To evaluate whether this trend could be found in Luxembourg (a small country between the Netherlands and France) we performed a retrospective study over a period of 10 years. Information concerning all Type 1 diabetic patients (aged 0-19 years at diagnosis), diagnosed between January 1, 1977 and December 31, 1986 was obtained through paediatricians, internists, general practitioners and the Luxembourg Diabetes Association (LDA). The LDA was used as the ascertainment group (to estimate the real number and incidence of Type 1 diabetes mellitus). During the study period 91 Type 1 diabetic patients aged between 0-19 years were diagnosed. An incidence of 11.2 was found in boys (0-19 years). Girls in the same age group showed a considerably lower incidence of 8.8. Standardised incidence (using as standard the world population) revealed an almost similar incidence in the Netherlands and Luxembourg (respectively 10.3 and 10.2) for the age group aged 0-14 years. In France a considerably lower incidence is found (3.6). To what extent different methodology contributes to the differences remains to be clarified. Further prospective studies are necessary to investigate the role of environmental and genetic factors. © 1988 Springer-Verlag. [less ▲]

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See detail[Diagnostic and prognostic value of plasma ANP determination after myocardial infarction].
Neyses, Ludwig UL; Biegel, H.; Heinrichs, S. et al

in Zeitschrift fur Kardiologie (1988), 77 Suppl 2

In the present study the prognostic value of ANP measurement was investigated in 52 patients undergoing coronary angiography. 22 normotensive and 30 hypertensive subjects were included. A significant ... [more ▼]

In the present study the prognostic value of ANP measurement was investigated in 52 patients undergoing coronary angiography. 22 normotensive and 30 hypertensive subjects were included. A significant inverse correlation between left ventricular ejection fraction (EF) and plasma ANP was found in normotensives, but not in hypertensives. In patients with chronic myocardial infarction, there was no difference in ANP levels compared to patients without infarction in either group, provided that EF was normal. However, hypertensives showed a 35% increase in ANP compared to normotensives. This was true for subjects with and without myocardial infarction. These results show that in normotensives ANP levels have a prognostic value on a statistical rather than an individual basis. This does not apply to hypertensives, whose ANP level is increased by factors other than impaired ejection fraction. [less ▲]

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See detailMise en œuvre de l'adage " fraus omnia corrumpit " dans le crédit documentaire irrévocable réalisable à terme
Prüm, André UL; Mattout, Jean-Pierre

in Droit et Pratique du Commerce International = International Trade Law and Practice (1988), 107(108), 107-119

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See detailMeasurement of the nalgesic efects of aspirin with a new experimantal algesimetric procedure
Fortser, Clemens; Anton, Fernand UL; Reeh, Peter-Werner et al

in Pain (1988), 32(2), 215-222

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See detailInsulin antibodies in diabetic children before treatment: A marker for islet B-cell destruction?
De Beaufort, Carine UL; Binder, C.; Bruining, G. J. et al

in Diabetic Medicine: A Journal of the British Diabetic Association (1988), 5(5), 441-443

Insulin antibodies were measured in the sera of 28 newly diagnosed diabetic children (age 8.0 ± 4.0 (±SD) years) prior to insulin therapy and after 3, 6, 9, and 12 months. The levels at diagnosis and ... [more ▼]

Insulin antibodies were measured in the sera of 28 newly diagnosed diabetic children (age 8.0 ± 4.0 (±SD) years) prior to insulin therapy and after 3, 6, 9, and 12 months. The levels at diagnosis and after 12 months were compared to endogenous insulin production at onset and after 12 to 14 months. Endogenous insulin production was evaluated through the measurement of 24-h urinary C-peptide excretion, fasting plasma C-peptide levels and plasma C-peptide levels after glucagon stimulation. Insulin antibodies were detected in 29% of the patients (8 out of 28). In all but one patient antibodies binding porcine and human insulin were detected. No relationship was found between the presence of antibodies binding human or porcine insulin at diagnosis and age. After 1 year 27 out of 28 patients presented insulin antibodies. No relationship was found between the presence of insulin antibodies before therapy and 1 year after therapy. Insulin antibodies prior to diagnosis showed no relationship with the urinary C-peptide excretion at diagnosis (with antibodies 67 ± 27%, without antibodies 76 ± 11%). However, after 1 year significantly lower urinary C-peptide excretions were found in patients with insulin antibodies prior to therapy (with antibodies, 17 ± 7%, without antibodies, 31 ± 5%, p < 0.02). Peak plasma C-peptide levels after 1 year were possibly lower in patients with insulin antibodies before treatment (with antibodies 0.17 ± 0.06 nmol/l, without antibodies 0.26 ± 0.04 nmol/l, p < 0.1). Fasting C-peptide levels did not differ significantly between the two groups after 1 year of therapy (with antibodies 0.11 ± 0.03 nmol/l, without antibodies 0.14 ± 0.02 nmol/l). Thus, insulin auto-antibodies may be a marker for islet B-cell destruction in Type 1 diabetes. [less ▲]

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See detailSelective excitation by capsaicin of mechano-heat sensitive nociceptors in rat skin
Szolcsanyi, Janos; Anton, Fernand UL; Reeh, Peter-Werner et al

in Brain Research (1988), 446(2), 262-268

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See detailDer „Fragebogen zur Erfassung von Formen der Krankheitsbewältigung“ (FEKB): II. Skalenkonstruktion und erste Befunde zu Reliabilität, Validität und Stabilität.
Klauer, Thomas; Filipp, Sigrun-Heide; Ferring, Dieter UL

in Trier: Universität, Fachbereich I – Psychologie. (1988)

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See detailundulated, a mutation affecting the development of the mouse skeleton, has a point mutation in the paired box of Pax 1.
Balling, Rudi UL; Deutsch, U.; Gruss, P.

in Cell (1988), 55(3), 531-5

undulated (un) homozygous mice exhibit vertebral malformations along the entire rostro-caudal axis. Pax 1, a murine paired box-containing gene, is expressed in ventral sclerotome cells and later in ... [more ▼]

undulated (un) homozygous mice exhibit vertebral malformations along the entire rostro-caudal axis. Pax 1, a murine paired box-containing gene, is expressed in ventral sclerotome cells and later in intervertebral disks along the entire vertebral column. We localized the Pax 1 gene on chromosome 2 between beta 2-microglobulin and the agouti locus to an area where un maps. DNA analysis of the un mutant revealed a point mutation in a highly conserved part of the paired box of Pax 1, leading to a Gly-Ser replacement. The chromosomal location and the mutation in the paired box of un mice in conjunction with Pax 1 gene expression in wild-type mice implicate a causative role of Pax 1 in generation of the vertebral column. [less ▲]

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See detail[Elevated levels of atrial natriuretic peptide and plasma catecholamines in arterial hypertension--indications for an interaction].
Neyses, Ludwig UL; Nitsch, J.; Biegel, T. et al

in Zeitschrift fur Kardiologie (1988), 77(7), 407-12

In this study plasma levels of atrial natriuretic peptide and of the catecholamines epinephrine and norepinephrine were investigated in hypertensive patients (HT) (n = 30). 22 normotensive patients (NT ... [more ▼]

In this study plasma levels of atrial natriuretic peptide and of the catecholamines epinephrine and norepinephrine were investigated in hypertensive patients (HT) (n = 30). 22 normotensive patients (NT) served as controls. Hypertensives showed an elevated ANP-level in comparison with controls (46.8 +/- 3.3 vs. 36.8 +/- 3.3 pg/ml, M +/- SEM, p less than 0.01). When patients with myocardial infarction or with reduced ejection fraction were excluded, the same relation was demonstrated (49.3 +/- 3.2 vs. 33.6 +/- 2.0 pg/ml, p less than 0.01). Plasma norepinephrine was 230.8 +/- 52.3 pg/ml in HT compared with 138.0 +/- 19.6 pg/ml in NT (p less than 0.05). Epinephrine was 70.8 +/- 10.5 vs. 54.8 +/- 9.7 pg/ml in HT and NT. To exclude an increased left ventricular enddiastolic - and hence left atrial - pressure as the cause for the elevation of ANP and norepinephrine, HT and NT were matched for the same levels of enddiastolic pressure (LVEDP) (n = 18). For each level of LVEDP ANP was higher in HT than in NT (p less than 0.01). The same held true for norepinephrine (p less than 0.05) and to a lesser extent for epinephrine (p = 0.09). Our results demonstrate that patients with essential hypertension exhibit markedly elevated levels for ANP and catecholamines which is not due to myocardial failure. We propose that the increased secretion of the vasodilatory hormone ANP serves as counterregulation against the vasoconstrictor norepinephrine. The endocrine function of the heart may play a pivotal role in the modulation of sympathetic activity. [less ▲]

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See detailA mouse gene homologous to the Drosophila gene caudal is expressed in epithelial cells from the embryonic intestine.
Duprey, P.; Chowdhury, K.; Dressler, G. R. et al

in Genes and Development (1988), 2(12A), 1647-54

A mouse gene, Cdx-1, was isolated from an embryonic cDNA library using a Drosophila caudal gene probe. The deduced amino acid sequence of Cdx-1 contains conserved sequence domains along the entire gene ... [more ▼]

A mouse gene, Cdx-1, was isolated from an embryonic cDNA library using a Drosophila caudal gene probe. The deduced amino acid sequence of Cdx-1 contains conserved sequence domains along the entire gene, as well as a highly conserved caudal-type homeo box. A structural comparison suggests a common ancestral origin of mouse Cdx-1 and Drosophila caudal. The expression of Cdx-1 during embryogenesis was analyzed by Northern blotting and in situ hybridization. Cdx-1-specific transcripts are localized in the epithelial lining of the intestines beginning at 14 days' gestation. The expression of Cdx-1 in the intestine continues into adulthood, but cannot be detected in any other tissues. The Cdx-1 gene is the first homeo-box-containing gene expressed in cells derived from the embryonic endoderm. [less ▲]

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See detailUrinary C-peptide: A useful tool for evaluating the endogenous insulin reserve in cohort and longitudinal studies of diabetes in childhood
De Beaufort, Carine UL; Den Boer, N. C.; Bruining, G. J. et al

in Annals of Clinical Biochemistry (1988), 25(5), 552-559

Increasing research into the remission phase of type I diabetes mellitus stresses the importance of a non-traumatic and reliable method for the evaluation of endogenous insulin production. We compared 24 ... [more ▼]

Increasing research into the remission phase of type I diabetes mellitus stresses the importance of a non-traumatic and reliable method for the evaluation of endogenous insulin production. We compared 24-h urinary C-peptide excretion (UCE) with plasma C-peptide values before and after stimulation with 1 mg glucagon in 24 type I diabetic children. Fasting plasma C-peptide values and stimulated plasma C-peptide values showed a linear correlation with 24 h UCE. Mean plasma C-peptide levels correlated inversely with the exogenous insulin dose. A slightly better correlation was found between the exogenous insulin dose and 24 h UCE. Control data of 24 h UCE were obtained from healthy siblings. A linear correlation with ages was found up to 10 years of age above which UCE values seem to reach a plateau. This effect of age, as well as the frequency of sampling was taken into account in the derivation of 95% reference intervals for UCE. The measurement of 24 h UCE appears to be a useful parameter to assess endogenous insulin production in diabetic children, provided that age is taken into account. [less ▲]

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See detailPolizei, Protest und Eskalation: Die Bedeutung der Konflikterfahrungen junger Polizeibeamter
Willems, Helmut UL

in Neue Soziale Bewegungen und Kontrolle (1988), 1(2), 11-20

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See detailMicrocomputers and the Teaching of English Language and Literature
Weber, Jean-Jacques UL

in Bulletin Nouvelles Technologies et Education (1988), 2

Detailed reference viewed: 66 (0 UL)
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See detailL'exemple d'un bourgeois et marchand de Bordeaux au milieu du XVIIe siècle
Voss, Peter UL

in Bulletin du Centre d'Histoire des Espaces Atlantiques (1988), 4

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See detailFragmented Selves and Hyphenated Neologisms in Salman Rushdie's Midnight's Children
Weber, Jean-Jacques UL

in Liverpool Papers in Language and Discourse (1988)

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See detailOn the accuracy of the Platzman's charting for loading estimations
Francis, Olivier UL

in Marées Terrestres Bulletin d'Informations (1988), (101), 7010-7018

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See detailZur Spezifität der Bewältigung schwerer körperlicher Erkrankungen: Eine vergleichende Analyse dreier diagnostischer Gruppen.
Klauer, Thomas; Ferring, Dieter UL; Filipp, Sigrun-Heide

in Trier: Universität, Fachbereich I – Psychologie. (1988)

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See detailArachidonic acid metabolites and airway epithelium-dependent relaxant factor
Tschirhart, Eric UL; Frossard, N.; Bertrand, C. et al

in Journal of Pharmacology and Experimental Therapeutics (1987), 243(1), 310-6

Exogenous arachidonic acid (10(-8) to 10(-4) M) contracted epithelium-free guinea pig tracheal strips. Intact tracheal strips were contracted slightly by low concentrations of arachidonic acid (10(-8) to ... [more ▼]

Exogenous arachidonic acid (10(-8) to 10(-4) M) contracted epithelium-free guinea pig tracheal strips. Intact tracheal strips were contracted slightly by low concentrations of arachidonic acid (10(-8) to 10(-5) M), but higher concentrations relaxed them. In contrast, when tracheal strips were precontracted with histamine or carbachol, exogenous arachidonic acid had no effect on epithelium-free preparations but induced concentration-dependent (10(-8) to 10(-4) M) relaxation of intact tracheal strips. The effects of arachidonic acid both in epithelium-free and epithelium-containing trachea were blocked by either indomethacin (10(-6) M) or aspirin (10(-4) M). Studies on the effects of exogenous arachidonic acid, performed with a "sandwich protocol," demonstrated that the postulated airway epithelium-dependent relaxant factor released by an intact tracheal strip relaxes an adjacent epithelium-free strip in the same organ bath. This relaxation is antagonized by indomethacin suggesting the involvement of a cyclooxygenase product in this phenomenon. Comparison of concentration-response curves for contractile agonists in epithelium-free preparations and in one containing epithelium suggests the mobilization of airway epithelium-dependent relaxant factor by histamine but not by carbachol. The effects of cyclooxygenase and lipoxygenase inhibitors indicated that both relaxant and contractile arachidonic acid metabolites are generated by epithelial and nonepithelial cells alike in response to contractile agonists. [less ▲]

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See detail[Elevated plasma flecainide concentrations in heart failure].
Nitsch, J.; Neyses, Ludwig UL; Kohler, U. et al

in Deutsche medizinische Wochenschrift (1946) (1987), 112(44), 1698-700

In 42 patients with heart failure who were on long-term treatment with flecainide (2 X 100 mg daily by mouth) plasma concentration of flecainide was measured before the morning dose and compared with the ... [more ▼]

In 42 patients with heart failure who were on long-term treatment with flecainide (2 X 100 mg daily by mouth) plasma concentration of flecainide was measured before the morning dose and compared with the clinical grade of heart failure or left ventricular ejection fraction (in the levo-angiogram). Mean plasma flecainide concentration was 415 +/- 244 ng/ml (110-1035 ng/ml), mean ejection fraction 55 +/- 17.7% (24-84%) (r = -0.60). In seven patients with plasma concentrations over 700 ng/ml (870 +/- 150 ng/ml) in clinical grade III or IV, ejection fractions were 24, 25, 25, 30, 33, 37 and 44%, respectively. In two patients (ejection fraction of 24 and 25%, respectively) the morning plasma concentration was around 1000 ng/ml. The results point to possible high plasma flecainide concentrations--at times in the toxic range--in patients who are in heart failure. In patients with marked reduction in left ventricular pumping function who are on long-term flecainide treatment, a reduction in dosage or monitoring of plasma flecainide concentration is indicated. [less ▲]

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See detailEin semantischer Atlas zur Kodierung alltagssprachlicher Verhaltensbeschreibungen nach dem Symlog-Raummodell
Orlik, Peter; Beck, Dieter; Becker, Ulrike et al

in International Journal of Small Group Research (1987), 3

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See detailDisplacements of the Earth's surface due to atmospheric loading: Effects on Gravity and Baseline Measurements
van Dam, Tonie UL; Wahr, John

in Journal of Geophysical Research (1987), 92

Atmospheric mass loads and deforms the Earth's crust. By performing a convolution sum between daily global barometric pressure data and mass loading Green's functions, we estimate the time dependent ... [more ▼]

Atmospheric mass loads and deforms the Earth's crust. By performing a convolution sum between daily global barometric pressure data and mass loading Green's functions, we estimate the time dependent effects of atmospheric loading, including those associated with short-term synoptic storms, on surface point positioning measurements and surface gravity observations. We calculate the response of both an oceanless Earth and an Earth with an inverted barometer ocean. Peak to peak vertical displacements are frequently 15-20 mm with accompanying gravity perturbations of 3-6 microgal. Baseline changes can be as large as 20 mm or more. The perturbations are largest at higher latitudes and during winter months. These amplitudes are consistent with the results f Rabbel and Zschau (1985) who modeled synoptic pressure disturbances as Gaussian functions of radius about a central point. Deformation can be adequately computes using real pressure data from points within about 1000 km of the station. Knowledge of local pressure alone, is not sufficient. Rabbel and Zschau's hypothesized corrections for these displacements, which use local pressure and regionally averaged pressure, prove accurate at points well inland but are, in general, inadequate within a few hundred kilometers of the coast. [less ▲]

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See detailContinuous subcutaneous insulin infusion in children
De Beaufort, Carine UL; Bruining, G. J.

in Diabetic Medicine: A Journal of the British Diabetic Association (1987), 4(2), 103-108

Insulin-dependent diabetes mellitus usually presents in childhood. Since it is generally accepted that persisting metabolic derangements contribute to the development of micro- and macrovascular ... [more ▼]

Insulin-dependent diabetes mellitus usually presents in childhood. Since it is generally accepted that persisting metabolic derangements contribute to the development of micro- and macrovascular complications, a primary aim of the management of children with diabetes is to achieve near normalization of metabolism. In adults continuous subcutaneous insulin infusion (CSII) has been used to optimize control. Despite a reluctance amongst paediatricians to use CSII in children, several studies with pumps have been performed in adolescents. The results of these studies are contradictory with respect to acceptability and achieved metabolic control. Thus, some authors report a near normalization of blood glucose concentrations, whereas others only find a temporary improvement. Patient selection seems to account for many of these differences. This suggests that methods ought to be developed to predict success or failure of CSII in a particular adolescent patient. For diabetic toddlers with their age-specific problems CSII may be a therapy of choice. So far, good acceptability and improved metabolic control are reported in this group. More studies are needed to confirm this. It is important that the diabetic clinic as well as the patient is organized to a high standard before starting CSII. Home blood glucose measurements, education, and a 24-h telephone service are essential factors for the management of diabetic children, treated conventionally or with CSII. [less ▲]

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See detailThe effect of carrageenan-induced inflammation on the sensitivity of unmyelinated skin nociceptors in rat
Kocher, Laurence; Anton, Fernand UL; Reeh, Peter-Werner et al

in Pain (1987), 29(3), 363-373

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See detailDe betekenis van John Deweys ken- en wetenschapstheorie voor de (theoretische) pedagogiek.
Biesta, Gert UL; Miedema, S.

in Pedagogische Verhandelingen: Tijdschrift voor Wijsgerige en Historische Pedagogiek (1987), 10(2), 96-106

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See detailDischarge patterns of afferent cutaneous nerve fibers from the rat's tail during prolonged noxious mechanical stimulation
Handwerker, Hermann-Otto; Anton, Fernand UL; Reeh, Peter-Werner

in Experimental Brain Research (1987), 65(3), 493-504

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See detailAntibodies to a 64,000 M(r) human islet cell antigen precede the clinical onset of insulin-dependent diabetes
Baekkeskov, S.; Landin, M.; Kristensen, J. K. et al

in Journal of Clinical Investigation (1987), 79(3), 926-934

Antibodies in sera from newly diagnosed insulin-dependent diabetes mellitus (IDDM) patients are directed to a human islet cell protein of relative molecular mass (M(r)) 64,000. Since IDDM seems to develop ... [more ▼]

Antibodies in sera from newly diagnosed insulin-dependent diabetes mellitus (IDDM) patients are directed to a human islet cell protein of relative molecular mass (M(r)) 64,000. Since IDDM seems to develop after a prodromal period of β-cell autoimmunity,, this study has examined whether 64,000 M(r) antibodies could be detected in 14 individuals who subsequently developed IDDM and five first degree relatives who have indications of altered β-cell function. Sera were screened by immunoprecipitation on total detergent lysates of human islets and positive sera retested on membrane protein preparations. Antibodies to the 64,000 M(r) membrane protein were consistently detected in 11/14 IDDM patients, and in all 5 first degree relatives. 10 IDDM patients were already positive in the first samples, obtained 4-91 mo before the clinical onset of IDDM, whereas 1 patient progressed to a high 64,000 M(r) immunoreactivity, at a time where a commencement of a decline in β-cell function was detected. 64,000 M(r) antibodies were detected before islet cell cytoplasmic antibodies (ICCA) in two patients. In the control groups of 21 healthy individuals, 36 patients with diseases of the thyroid and 5 SLE patients, the 64,000 M(r) antibodies were detected in only one individual, who was a healthy sibling to an IDDM patient. These results suggest that antibodies against the M(r) 64,000 human islet protein are an early marker of β-cell autoimmunity and may be useful to predict a later development of IDDM. [less ▲]

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See detailInvestment and the Inflation-Unemployment Trade-off in a Macroeconomic Rationing Model with Monopolistic Competition
Sneessens, Henri UL

in European Economic Review (1987), 31(3), 781-815

This paper develops a stylized macroeconomic rationing (or disequilibrium) model where the three well-known regimes of Keynesian Unemployment, Classical Unemployment and Repressed Inflation’ are ... [more ▼]

This paper develops a stylized macroeconomic rationing (or disequilibrium) model where the three well-known regimes of Keynesian Unemployment, Classical Unemployment and Repressed Inflation’ are explicitly distinguished and wherein prices and the capital stock are endogenously determined by profit maximizing firms. The framework is one of monopolistic competition. The macroeconomic price and employment relationships are derived by explicit aggregation over individual firms. Because different firms can be in different regimes, the three regimes mentioned above always coexist at the aggregate level and do so in proportions that may vary through time. This is exactly the picture conveyed by business survey results. As a result of competition, the number of firms, hence the aggregate production capacity, adjusts in the long run until pure profits are equal to zero. [less ▲]

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See detailExperimental alternatives in inducing systems of behavior classifications from everyday language
Krolak-Schwerdt, Sabine UL

in International Journal of Small Group Research (1987), 3

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See detailQuantitative sensory examination in diabetic children: Assessment of thermal discrimination
Heimans, J. J.; Bertelsmann, F. W.; De Beaufort, Carine UL et al

in Diabetic Medicine: A Journal of the British Diabetic Association (1987), 4(3), 251-253

Vibration perception thresholds (VPTs) and thermal discrimination thresholds (TDTs) were investigated in 55 insulin-dependent diabetic children aged 11.3 ± 3.9 years (mean ± SD) and in 81 controls. There ... [more ▼]

Vibration perception thresholds (VPTs) and thermal discrimination thresholds (TDTs) were investigated in 55 insulin-dependent diabetic children aged 11.3 ± 3.9 years (mean ± SD) and in 81 controls. There was no significant difference in VPTs between the two groups. TDTs were significantly higher in the group of diabetic children (p < 0.03). Eight diabetic children had abnormal thermal sensation and one child had abnormal vibratory sensation. TDT correlated positively with duration of diabetes mellitus (r = 0.25; p < 0.05). Both investigations can be carried out easily and are unobtrusive, which is an important advantage in the examination of children. [less ▲]

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See detail[Resuscitation of a 36-year-old patient with a short PQ time and a history of Hodgkin's disease].
Neyses, Ludwig UL; Nitsch, J.; Manz, M. et al

in Der Internist (1987), 28(3), 196-9

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See detailInhibition of flecainide absorption by activated charcoal.
Nitsch, J.; Kohler, U.; Neyses, Ludwig UL et al

in The American journal of cardiology (1987), 60(8), 753

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See detailApplication de l'adage "fraus omnia corrumpit" à propos des garanties à première demande
Prüm, André UL

in Bulletin Droit et Banque (1987)

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See detailAirway epithelium releases a relaxant factor: demonstration with substance P
Tschirhart, Eric UL; Landry, Y.

in European Journal of Pharmacology (1987), 132(1), 103-4

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See detailDe invloed van John Dewey op de Nederlandse pedagogiek.
Biesta, Gert UL; Miedema, S.

in Pedagogische Verhandelingen: Tijdschrift voor Wijsgerige en Historische Pedagogiek (1987), 10(2), 324-335

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See detailDegree of methylation of transgenes is dependent on gamete of origin.
Sapienza, C.; Peterson, A. C.; Rossant, J. et al

in Nature (1987), 328(6127), 251-4

Data derived from both pronuclear transplantation experiments and classical genetic experiments indicate that the maternal and paternal genetic contributions to the mammalian zygote nucleus do not ... [more ▼]

Data derived from both pronuclear transplantation experiments and classical genetic experiments indicate that the maternal and paternal genetic contributions to the mammalian zygote nucleus do not function equivalently during subsequent development. These observations have been interpreted as resulting from differential 'genome imprinting' during male and female gametogenesis. The molecular mechanism responsible for genome imprinting is unknown, but data gathered to date require that the mechanism fulfill at least four criteria: (1) the imprint must be physically linked to the pronucleus; (2) the imprint must persist through DNA replication and cell division; (3) the mechanism must be capable of affecting gene expression; and (4) the mechanism must be capable of switching the identity of the imprint from one sex to the other in successive generations. One molecular mechanism which could satisfy the first three criteria is differential DNA methylation during gametogenesis itself, or before formation of the zygote nucleus during embryogenesis. We present data indicating that the methylation patterns of exogenous DNA sequences in transgenic mice can be changed by switching their gamete of origin in successive generations. These data suggest that DNA methylation can also satisfy the fourth criterion for an imprinting mechanism. [less ▲]

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See detailRecomputation of the Green's functions for tidal loading estimations
Francis, Olivier UL; Dehant, V.

in Marées Terrestres Bulletin d'Informations (1987), (100), 6962-6986

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See detailNonequilibrium Phase Transitions in Solid Catalysts for Oxidation
Greger, Manfred UL; Riekert, Lothar

in Berichte der Bunsengesellschaft für physikalische Chemie (1987), 91

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See detailAu carrefour des transitions : fécondité, niveau de vie et culture populaire
Leboutte, René UL

in Annales de Démographie Historique (1987)

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