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See detailFiltrage de diffusions faiblement bruitées dans le cas corrélé
Schiltz, Jang UL

in Comptes Rendus de l'Académie des Sciences. Série I. Mathématique (1997), 325

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See detailAlgorithms For Phylogeny Reconstruction In a New Mathematical Model
Lenzini, Gabriele UL; Marianelli, Silvia

in Calcolo (1997), 1-4(34), 1-24

The evolutionary history of a set of species is represented by a tree called phylogenetic tree or phylogeny. Its structure depends on precise biological assumptions about the evolution of species ... [more ▼]

The evolutionary history of a set of species is represented by a tree called phylogenetic tree or phylogeny. Its structure depends on precise biological assumptions about the evolution of species. Problems related to phylogeny reconstruction (i.e., finding a tree representation of information regarding a set of items) are widely studied in computer science. Most of these problems have found to be NP-hard. Sometimes they can solved polynomially if appropriate restrictions on the structure of the tree are fixed. This paper summarizes the most recent problems and results in phylogeny reconstruction, and introduces an innovative tree model, called Phylogenetic Parsimonious Tree, which is justified by significant biological hypothesis. Using PPT two problems are studied: the existence and the reconstruction of a tree both when sequences of characters and partial order on interspecies distances are given. We rove complexity results that confirm the hardness of this class of problems. [less ▲]

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See detailOrdering problems in fermionic relativistic quantum mechanics
del Sol Mesa, Antonio UL

in International Journal of Modern Physics A (1997)

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See detailPedestrian guide to analyzing sequence databases
Rost, B.; Schneider, Reinhard UL; Sander, C.

in WWW-publication (1997)

Over the past few years our means of communication have changed rapidly due to the growth of the World Wide Web (WWW). The Web enables molecular biologists to immediately access databases, scan literature ... [more ▼]

Over the past few years our means of communication have changed rapidly due to the growth of the World Wide Web (WWW). The Web enables molecular biologists to immediately access databases, scan literature, find information about related research and researchers, and to trace cell cultures. Wet-lab biologists can uncover information about the protein of interest without having to become experts in sequence analysis. Here, we present a variety of tools; provide an overview of the state-of-the art in sequence analysis; and described some of the principles of the methods. [less ▲]

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See detailInvestigation of the Met-267 Arg exchange in isoform 1 of the human plasma membrane calcium pump in patients with essential hypertension by the amplification-created restriction site technique.
Benkwitz, C.; Kubisch, C.; Kraft, K. et al

in Journal of Molecular Medicine (1997), 75(1), 62-6

Alterations in Ca2+ homeostasis have been proposed to be a primary factor in the pathogenesis of essential hypertension. In this disease increased intracellular Ca2+ levels have repeatedly been reported ... [more ▼]

Alterations in Ca2+ homeostasis have been proposed to be a primary factor in the pathogenesis of essential hypertension. In this disease increased intracellular Ca2+ levels have repeatedly been reported in various cell types. Because of its prominent role in cellular calcium homeostasis in vascular smooth muscle cells, modifications of the plasma membrane Ca2+-ATPase (PMCA) pump have been suggested to contribute to an increased contractile tone of small blood vessels. This pump is a calmodulin-dependent Ca2+-ATPase that ejects Ca2+ from the cytosol into the extracellular space. Recently a mutational thymidine (T)-->guanosine (G) transversion in isoform 1 of the PMCA has been identified resulting in the substitution of a methionine (Met) by an arginine (Arg) at amino acid position 267 in a highly conserved domain of the pump molecule. The aim of our study was to determine the prevalence of this polymorphism in the normal population and to investigate whether the Met-267 Arg occurs more frequently in patients with essential hypertension than in normotensives. To detect the mutational change we modified a method based on the technique of amplification-created restriction sites (ACRS) using three base exchanges in the diagnostic primer. Samples from 100 hypertensive and 60 normotensive subjects revealed a thymidine at nucleotide position 981. These data suggest that ACRS is feasible in spite of extensive primer modifications (e.g., three mismatched bases) in contrast to the previously used one or two and may therefore be conceptually suitable to detect almost any base changes in the genome. The described T-->G transversion is a rare polymorphism and is presumably not related to common forms of essential hypertension. [less ▲]

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See detailGezin en moraal
Doornenbal,J.; Biesta, Gert UL; Heyting,G.F.

in Comenius (1997), 17(4), 275-324

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See detailA Return to the Dewey-Russell Opposition.
Biesta, Gert UL

in [Review Essay] Culture & Psychology (1997), 3(1), 99-105

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See detailActions exponentielles et noyaux d'opérateurs
Molitor-Braun, Carine UL

in Travaux Mathématiques (1997), 9

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See detailMark-up pricing and bilateral monopoly
Irmen, Andreas UL

in Economics Letters (1997), 54(2), 179-184

It is an empirically established fact that managers use cost based percentage margins when they price their goods. As a consequence, percentage mark-ups should be determined as equilibrium choices. This ... [more ▼]

It is an empirically established fact that managers use cost based percentage margins when they price their goods. As a consequence, percentage mark-ups should be determined as equilibrium choices. This paper incorporates this empirical observation into the analysis of competition among bilateral monopolists. [less ▲]

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See detailPestalozzi - fermerait-il nos écoles?
Tröhler, Daniel UL

in Bulletin du Centre de Documentation et de Recherche Pestalozzi (1997), 22

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See detailQuantitative examination of calcitonin gene-related peptide immunoreactive nerve fibers in the cat knee joint capsule
Heppelmann, Bernd; Shahbazian, Zarah; Hanesch, Ulrike UL

in Anatomy & Embryology (1997), 195

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See detailCardiac myocytes and fibroblasts contain functional estrogen receptors.
Grohe, C.; Kahlert, S.; Lobbert, K. et al

in FEBS letters (1997), 416(1), 107-12

Gender-based differences found in cardiovascular diseases raise the possibility that estrogen may have direct effects on cardiac tissue. Therefore we investigated whether cardiac myocytes and fibroblasts ... [more ▼]

Gender-based differences found in cardiovascular diseases raise the possibility that estrogen may have direct effects on cardiac tissue. Therefore we investigated whether cardiac myocytes and fibroblasts express functional estrogen receptors. Immunofluorescence demonstrated estrogen receptor protein expression in both female and male rat cardiac myocytes and fibroblasts. Nuclear translocation of the estrogen receptor protein was observed after stimulation of cardiomyocytes with 17beta-estradiol (E2). Cells transfected with an estrogen-responsive reporter plasmid showed that treatment with E2 induced a significant increase in reporter activity. Furthermore, E2 induced a significant increase in expression of the estrogen receptors alpha and beta, progesterone receptor and connexin 43 in cardiac myocytes. Cardiac myocytes and fibroblasts contain functional estrogen receptors and estrogen regulates expression of specific cardiac genes. These data suggest that gender-based differences in cardiac diseases may in part be due to direct effects of estrogen on the heart. [less ▲]

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See detailEffects of an acute inflammation on the proportion of CGRP- and SP-containing joint afferents
Hanesch, Ulrike UL; Heppelmann, Bernd

in Neuroscience Letters (1997), 233

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See detailRetrospektive Bewertungen des eigenen Lebens: LZG – Lebenszufriedenheits-Graph.
Ferring, Dieter UL; Filipp, Sigrun-Heide

in Zeitschrift für Entwicklungspsychologie und Padagogische Psychologie (1997), 29(1)

Detailed reference viewed: 81 (0 UL)
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See detailAnalysis of Subspace System Identification Methods Based on Instrumental Variables and Subspace Fitting
Viberg, Mats; Wahlberg, Bo; Ottersten, Björn UL

in Automatica (1997), 33

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See detailDe toekomst van de historische pedagogiek
Bakker,P.C.M.; Selten,P.J.H; Biesta, Gert UL

in Comenius (1997), 17(3), 195-244

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See detailHuman umbilical cord blood-derived eosinophils cultured in the presence of IL-3 and IL-5 respond to fMLP with [Ca2+]i variation and O2- production
Zardini, D. M.; Heuschling, Paul UL; Gallois, A. et al

in Journal of Immunological Methods (1997), 205(1), 1-9

In the presence of interleukin-3 and interleukin-5, eosinophil precursors from human umbilical cord blood mononuclear cells were regularly differentiated into mature eosinophil-like cells expressing ... [more ▼]

In the presence of interleukin-3 and interleukin-5, eosinophil precursors from human umbilical cord blood mononuclear cells were regularly differentiated into mature eosinophil-like cells expressing normal morphology and cyanide-resistant peroxidase. O2- production and [Ca2+]i rise were measured in these in vitro differentiated eosinophils after fMLP stimulation; with dihydrorhodamine-123 and fura-2, respectively. Umbilical cord blood-derived eosinophils responded to fMLP (0.01 nM to 3 microM) with a concentration-dependent production of O2- (EC50 = 63.1 +/- 17.2 nM; Emax = 71.0 +/- 6.2 pmol/min/10(6) cells). O2- production was correlated with an fMLP concentration-dependent increase in [Ca2+]i (EC50 = 32.5 +/- 14.9 nM; Emax = 200.0 +/- 23.9 nM). These results indicate that human umbilical cord blood-derived eosinophils demonstrate functional characteristics similar to adult human peripheral blood eosinophils after activation by fMLP. Therefore, the large numbers of eosinophils (2-3 x 10(6)/ml cord blood) which can be obtained by culture of human cord blood mononuclear cells may serve as a useful model for future studies which will provide insight into the pathogenesis of diseases associated with eosinophils. [less ▲]

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See detailSchule und Sport aus der Sicht jugendlicher Vereinsmitglieder - ein internationaler Vergleich
Steffgen, Georges UL; Schwenkmezger, Peter; Fröhling, Roland

in Sportunterricht (1997), 46(7), 292-300

The findings are presented of an international comparative study of youth sports club members to determine their perspectives on the relationship between school and sport, and the influence of physical ... [more ▼]

The findings are presented of an international comparative study of youth sports club members to determine their perspectives on the relationship between school and sport, and the influence of physical education on sport participation and membership of sports clubs. Participants in the study comprised two groups of 344 sports club members and school pupils from Luxembourg and Germany. Differences in terms of age, sex and school type were taken into account. The main findings indicate that school and physical education in both countries only have a slight, indirect influence on young people's decisions to become members of sports clubs and participate in sport. Indeed, the pressures of school may in some cases be an obstacle to intensive sports activity and training outside school. This is particularly so in Luxembourg where students often have to refuse participation in sports competitions and training because of the pressures of school work. Some final thoughts are presented on ways in which school and physical education could become more supportive of youth sport training and club membership, and could give greater encouragement to young people to succeed in competitive and high level sport. [less ▲]

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See detailGezin en moraal: Gezinsopvoeding als het morele fundament van de samenleving?
Doornenbal, J.; Heyting, G. F.; Biesta, Gert UL

in Comenius (1997), 17(4), 275-280

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See detailAntagonistic interactions between FGF and BMP signaling pathways: a mechanism for positioning the sites of tooth formation.
Neubuser, A.; Peters, H.; Balling, Rudi UL et al

in Cell (1997), 90(2), 247-55

Vertebrate organogenesis is initiated at sites that are often morphologically indistinguishable from the surrounding region. Here we have identified Pax9 as a marker for prospective tooth mesenchyme prior ... [more ▼]

Vertebrate organogenesis is initiated at sites that are often morphologically indistinguishable from the surrounding region. Here we have identified Pax9 as a marker for prospective tooth mesenchyme prior to the first morphological manifestation of odontogenesis. We provide evidence that the sites of Pax9 expression in the mandibular arch are positioned by the combined activity of two signals, one (FGF8) that induces Pax9 expression and the other (BMP2 and BMP4) that prevents this induction. Thus it appears that the position of the teeth is determined by a combination of two different types of signaling molecules produced in wide but overlapping domains rather than by a single localized inducer. We suggest that a similar mechanism may be used for specifying the sites of development of other organs. [less ▲]

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See detailAlter Wein in neuen Schläuchen? Agenda 21 und Stadtentwicklung -
Hesse, Markus UL

in Politische Ökologie : die Reihe für Querdenker und Vordenkerinnen (1997), (52), 38-41

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See detailUne caractérisation différentielle des points de Weierstrass généralisés d'une surface de Riemann compacte de genre g > 1
Leprévost, Franck UL

in Journal de Mathématiques Pures et Appliquées (1997), 76

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See detailEtude de differentes methodes pour la mise en evidence des autoanticorps anti-glutamate-decarboxylase associes au developpement du diabete insulinodependant
Humbel, R. L.; Guillaume, A. C.; Schmit, P. et al

in Immuno-Analyse et Biologie Specialisee (1997), 12(5), 275-279

Autoantibodies to glutamate-decarboxylase (GAD) are present in the serum of patients with insulin dependent diabetes (DID) even before the development of the overt diabetes. These antibodies react ... [more ▼]

Autoantibodies to glutamate-decarboxylase (GAD) are present in the serum of patients with insulin dependent diabetes (DID) even before the development of the overt diabetes. These antibodies react predominantly with the native GAD. Various methods have been studied (radio immunoassay [RIA] and enzyme- linked immunosorbent assay [ELISA]). It was observed that at the present time only RIA-tests, in which GAD is presented in fluid phase, are able to detect antibodies. [less ▲]

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See detailSurface-induced organization of linear molecules on nanostructured polytetrafluoroethylene: Crystalline state of poly[vinylidenefluoride-trifluoroethylene].
Krüger, Jan-Kristian UL; Heydt, B.; Fischer, C. et al

in Physical Review. B, Condensed Matter and Materials Physics (1997), 55(6), 3497-3506

Highly crystalline and uniaxial-oriented polytetrafluoroethylene films, nanostructured in one dimension, were used to produce a fully crystalline, thermoreversible morphology in the ferroelectric ... [more ▼]

Highly crystalline and uniaxial-oriented polytetrafluoroethylene films, nanostructured in one dimension, were used to produce a fully crystalline, thermoreversible morphology in the ferroelectric copolymer poly[vinylidenefluoride-trifluoroethylene]. The resulting state is built up of regularly stacked lamellar crystals of about 100 nm thickness and lateral dimensions of about 6 μm. [less ▲]

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See detailEffects of moexiprilat on oestrogen-stimulated cardiac fibroblast growth.
Grohe, C.; Kahlert, S.; Lobbert, K. et al

in British journal of pharmacology (1997), 121(7), 1350-4

1. The effects of 2-2-(1-(ethoxycarbonyl)-3-phenylpropyl)-[amino-oxopropyl]-6,7-dimethoxy- 1,2,3,4-tetrahydroisoquinoline-3 carboxylic acid (moexiprilat), 17beta-oestradiol (E2), oestrone (ES) and ... [more ▼]

1. The effects of 2-2-(1-(ethoxycarbonyl)-3-phenylpropyl)-[amino-oxopropyl]-6,7-dimethoxy- 1,2,3,4-tetrahydroisoquinoline-3 carboxylic acid (moexiprilat), 17beta-oestradiol (E2), oestrone (ES) and angiotensin II (AII) on growth and activation of oestrogen receptors and the immediate-early gene egr-1 were investigated in neonatal rat cardiac fibroblasts of female and male origin. 2. In BrdU proliferation assays, oestrone (10(-7)- 10(-9) M) stimulated cardiac fibroblast growth in a concentration-dependent fashion (maximum at 10(-7) M, 4.0 fold +/- 0.14 in female and 3.1 fold +/- 0.06 in male cells, n=9, P<0.05), while E2 (10(-7)-10(-9) M) had no effect. Moexiprilat (10(-7)M) completely inhibited oestrone-induced cardiac fibroblast growth. 3. Angiotensin II (10(-7) M) induced cardiac fibroblast growth (female 4.1 fold +/- 0.1/male 3.9 fold +/- 0.2; n=9, P<0.05). Angiotensin II induced oestrogen receptor (maximum 21.8 fold at 60 min) and egr-1 (maximum 47.5 fold at 60 min) expression in a time-dependent fashion. 4. In immunoblot experiments, oestrogen activated oestrogen receptor (ES: 12.8 fold +/- 2.0; E2: 14.7 fold +/- 4.9; n=3, P<0.05) and egr-1 (ES: 5.1 fold, +/- 0.24; E2: 3.8 fold, +/- 0.25; n=3, P<0.05) expression. The induction of oestrogen receptor and egr-1 protein expression was time-dependent and inhibited by moexiprilat. 5. Our results show that oestrone and 17beta-oestradiol reveal a significant difference in their potential to activate cardiac fibroblast growth in female and male cells and that oestrone-stimulated growth is inhibited by moexiprilat. The inhibition of oestrone-stimulated cardiac fibroblast growth by moexiprilat may contribute to the beneficial effects seen in postmenopausal women with hypertensive heart disease treated with ACE inhibitors. [less ▲]

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See detailPsychophysiological responses to food exposure: an experimental study in binge eaters
Vögele, Claus UL; Florin, Irmela

in International Journal of Eating Disorders (1997), (21), 147-157

Objective: The aim of the present study was to investigate psychophysiological responses to food exposure in binge eaters. Method: Thirty female volunteers reporting regular binge attacks were compared ... [more ▼]

Objective: The aim of the present study was to investigate psychophysiological responses to food exposure in binge eaters. Method: Thirty female volunteers reporting regular binge attacks were compared with 30 nonbinge eaters. Subjects attended individually for the single laboratory session. Continuous measures of heart rate (HR), blood pressure (BP), electroder- mal activity (EDA), and respiration rate were taken during rest and exposure to their favorite binge food. In addition, psychophysiological monitoring continued while subjects were al- lowed to eat after food exposure. Participants also completed inventories assessing restrained eating style (FEV, Revised Restraint Scale). Ratings of nervousness, distress, desire to binge, and hunger were collected repeatedly throughout the experiment. Results: The results indi- cate higher psychophysiological arousal in binge eaters than in nonbinge eaters. Binge eaters maintained a higher arousal level in BP and EDA throughout the food exposure trial than controls. HR during food exposure predicted the relative amount of food consumed during the eating trial across all subjects. This relationship, however, was more pronounced in binge eaters than controls and in restrained compared to unrestrained binge eaters. Discussion: The implications of these results are discussed in terms of conditioning and arousal models of cue reactivity in binge eating. © 1997 by John Wiley & Sons, Inc. Int J Eat Disord 21: 147–157, 1997. [less ▲]

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See detailStructural and functional similarities between the human cytoskeletal protein zyxin and the ActA protein of Listeria monocytogenes.
Golsteyn, R. M.; Beckerle, M. C.; Koay, T. et al

in Journal of cell science (1997), 110 ( Pt 16)

The intracellular bacterial parasite Listeria monocytogenes produces ActA protein at its surface to facilitate the localized assembly of actin-filled comets that are required for movement. The ... [more ▼]

The intracellular bacterial parasite Listeria monocytogenes produces ActA protein at its surface to facilitate the localized assembly of actin-filled comets that are required for movement. The organization of actin in Listeria comets shows striking similarity to the organization of actin at the plasma membrane of mammalian cells. Therefore we examined the possibility that an ActA-like protein is present in mammalian cells. By using antibodies directed against ActA, we identified zyxin as an ActA related protein in a number of cell types. We compared the functions of ActA and zyxin by transient expression of variants tagged with an inner plasma membrane localization sequence (a CAAX box). Targeting of the proline rich domain of zyxin to the plasma membrane disrupts the actin cytoskeleton and cell shape in a manner similar to that which occurs with membrane-targeted ActA sequences. A chimeric protein composed of the N-terminal domain of ActA fused to the N-terminal and central domains of zyxin induced a full ActA response in cells. Furthermore, zyxin and ActA exhibit common protein partners in vitro. On the basis of the shared properties of zyxin and ActA, we propose that zyxin enhances actin organizing activity in mammalian cells. [less ▲]

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See detailHierarchy of Norms in European Community Law
Hofmann, Herwig UL; Weiler, J. H. H.; Ballmann, Alexander et al

in Certain Rectangular Problems of European Integration (1997), II(Project IV/95/02),

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See detailMaximum Likelihood Array Processing in Spatially Correlated Noise Fields Using Parametrized Signals
Viberg, Mats; Stoica, Petre; Ottersten, Björn UL

in IEEE Transactions on Signal Processing (1997), 45(4), 9961004

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See detailCalcitonin gene-related peptide- and substance P-like immunoreactive fibers in the spermatic nerve and testis of the dog.
Tamura, Ryoko; Hanesch, Ulrike UL; Schmidt, Robert et al

in Neuroscience Letters (1997), 235

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See detailStaatliche Lehrerbildung in der Zeit der Helvetik und die Rolle Pestalozzis
Tröhler, Daniel UL

in Beiträge zur Lehrerbildung (1997), 15(3), 293-303

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See detailSelbstbewertungen und selektive Präferenz für temporale vs. Soziale Vergleichsinformation bei alten und sehr alten Menschen.
Filipp, Sigrun-Heide; Ferring, Dieter UL; Mayer, Anne-Kathrin et al

in Zeitschrift für Sozialpsychologie (1997)

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See detailSuperheavy nuclei in selfconsistent nuclear calculations
Rutz, K.; Bender, M.; Bürvenich, T. et al

in AIP Conference Proceedings (1997), 56(1), 238-243

The shell structure of superheavy nuclei is investigated within various parametrizations of relativistic and nonrelativistic nuclear mean-field models. The heaviest known even-even nucleus 156 264Hs108 is ... [more ▼]

The shell structure of superheavy nuclei is investigated within various parametrizations of relativistic and nonrelativistic nuclear mean-field models. The heaviest known even-even nucleus 156 264Hs108 is used as a benchmark to estimate the predictive value of the models. From that starting point, doubly magic spherical nuclei are searched in the region Z51102140 and N5134–298. They are found at (Z5114 , N5184), (Z5120 , N5172), or at (Z5126 , N5184), depending on the parametrization. [less ▲]

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See detailSpace-charge controlled conduction in low-temperature-grown molecular-beam epitaxial GaAs,
Kordoš, P.; Marso, Michel UL; Förster, A. et al

in Applied Physics Letters (1997), 71

Current transport in low-temperature (LT) molecular-beam epitaxial GaAs grown at 200-300 °C on an n+ GaAs substrate is studied by means of current–voltage–temperature characteristics. The resistivity of ... [more ▼]

Current transport in low-temperature (LT) molecular-beam epitaxial GaAs grown at 200-300 °C on an n+ GaAs substrate is studied by means of current–voltage–temperature characteristics. The resistivity of LT GaAs at low electric fields is rho>108 Ohm cm, much higher than resulting from van der Pauw measurements. It is found that the measured resistivity decreases with increasing the LT GaAs thickness. This is explained by space-charge effect in the vicinity of n+/LT GaAs junction and subsequent suppression of hopping conduction in the high-field junction region. [less ▲]

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See detailOnmogelijke opvoeding. Kanttekeningen bij de pedagogische overdrachtsmetafoor.
Biesta, Gert UL

in Comenius (1997), 17(4), 312-324

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See detailDer Grossvater Pestalozzis als pietistisch-pädagogischer Vermittler? Einleitung
Tröhler, Daniel UL

in Neue Pestalozzi-Blätter (1997), 3(1), 28-29

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See detailPain, Anxiety, and Cooperativeness in Children with Cerebral Palsy after Rhizotomy: Changes Throughout Rehabilitation
Miller, A. Cate; Johann-Murphy, Marjorie; Pit-Ten Cate, Ineke UL

in Journal of Pediatric Psychology (1997), 22(5), 689-705

Assessed pain, anxiety, physical functioning, and cooperativeness in 32 children with spastic cerebral palsy. This is the first study to assess children throughout rehabilitation following selective ... [more ▼]

Assessed pain, anxiety, physical functioning, and cooperativeness in 32 children with spastic cerebral palsy. This is the first study to assess children throughout rehabilitation following selective posterior rhizotomy. Results of the Observational Scale of Behavioral Distress and observer Liken ratings confirmed the hypothesis that children's pain and anxiety decrease over time. Children's physical functioning and cooperativeness improve over time. No significant correlation was found between pain and changes in physical functioning. Cognitive impairment, parental involvement, and children's pain behaviors explained 77% and 56% of the variance in two forms of cooperativeness. Research and clinical implications are discussed, and special considerations regarding pain assessment and management in this population are addressed. [less ▲]

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See detailLes exigences de prix dans les contrats internationaux
Prüm, André UL

in Cahiers de Droit de l'Entreprise (1997), (5),

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See detailQuantification of wild-type mitochondrial DNA and its 4.8-kb deletion in rat organs.
Filser, N.; Margue, Christiane UL; Richter, C.

in Biochemical and biophysical research communications (1997), 233(1), 102-7

Oxidative damage to mitochondrial DNA (mtDNA) is considered a major contributor in aging. An age-dependent increase of oxidative damage and of the quantity of partially deleted mtDNA was reported for ... [more ▼]

Oxidative damage to mitochondrial DNA (mtDNA) is considered a major contributor in aging. An age-dependent increase of oxidative damage and of the quantity of partially deleted mtDNA was reported for several rat and human organs. Here, a systematic investigation of ten different tissues and organs of 20-months-old rats was performed. The amount of mtDNA and age-dependent 4.8 kb deletion (delta mtDNA4834) was determined by competitive polymerase chain reaction, along with the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSHPx). The data were related to the corresponding metabolic rates. MtDNA content was highest in heart and lowest in spleen. delta mtDNA4834 was detected in all ten tissues and organs, and its amount was highest in liver and lowest in intestine. In heart, lung, muscle, and bone-marrow the deletion could not be quantified because of a point mutation, an A-->T transition at position 8107. Activities of SOD and GSHPx were highest in liver and lowest in intestinal mucosa. A negative correlation between mtDNA content and delta mtDNA4834, and a positive correlation between metabolic rate, GSHPx, and the deletion was found. These results suggest that the occurrence of delta mtDNA4834 in rat is related to oxidative stress. [less ▲]

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See detailAnger suppression, reactivity and hypertension risk: Gender makes a difference
Vögele, Claus UL; Cheeseman, Karen; Jarvis, Ann

in Annals of Behavioral Medicine : A Publication of the Society of Behavioral Medicine (1997), 19

The present study investigated gender-related differences in cardiovascular reactivity and the role of anger inhibition and risk for future hypertension. Tonic blood pressure served as an index of ... [more ▼]

The present study investigated gender-related differences in cardiovascular reactivity and the role of anger inhibition and risk for future hypertension. Tonic blood pressure served as an index of hypertension risk. Twenty-eight female and 26 male college students with high and low normal blood pressure were recruited on the basis of their mean arterial pressure. Continuous measures of heart rate and blood pressure were taken while participants carried out a series of behavioral manoeuvres including mental arithmetic, interpersonal challenge, a frustrating psychomotor test, and the cold pressor test. Participants also completed inventories assessing trait anxiety, trait anger, anger expression, and Type A. The results are in concordance with previous findings and show higher cardiovascular reactivity in men than in women and in subjects at risk for hypertension. Within the male group, a combination of hypertension risk and anger suppression led to the highest reactivity, whereas in female subjects, differences in anger-in had no effect on reactivity. The implications of these results are discussed in light of sex differences in cardiovascular morbidity and mortality. [less ▲]

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See detailEnhancing the Web's infrastructure: from caching to replication
Baentsch, Michael; Baum, Lothar; Molter, Georg et al

in IEEE Internet Computing (1997), 1(2), 18-27

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See detailMeasles virus transmission from infected to immune individuals - Implications for measles control and elimination
Vardas, E.; Andre, M.; Kreis, Stephanie UL et al

in South African Medical Journal (1997), 87(12), 1709

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See detailIsolation of the Pax9 cDNA from adult human esophagus.
Peters, H.; Schuster, G.; Neubuser, A. et al

in Mammalian Genome (1997), 8(1), 62-4

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See detailSaar-Lor-Lux - Die Bedeutung der lokalen grenzüberschreitenden Kooperation für den europäischen Integrationsprozeß.
Schulz, Christian UL; Brücher, Wolfgang

in Magazin Forschung (1997), (1), 46-53

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See detailPsychoneuroimmunological correlates of persiting pain in patients who underwent discectomy
Geiss, Andrea; Varadi, E; Steinbach, Klaus et al

in Neuroscience Letters (1997), 237(2), 65-68

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See detailThe HSSP database of protein structure-sequence alignments
Schneider, Reinhard UL; deDaruvar, A.; Sander, C.

in Nucleic Acids Research (1997), 25(1), 226-230

HSSP is a derived database merging structural (3-D) and sequence (1-D) information. For each protein of known 3-D structure from the Protein Data Bank (PDB), the database has a multiple sequence alignment ... [more ▼]

HSSP is a derived database merging structural (3-D) and sequence (1-D) information. For each protein of known 3-D structure from the Protein Data Bank (PDB), the database has a multiple sequence alignment of all available homologues and a sequence profile characteristic of the family. The list of homologues is the result of a database search in SwissProt using a position-weighted dynamic programming method for sequence profile alignment (MaxHom). The database is updated frequently. The listed homologues are very likely to have the same 3-D structure as the PDB protein to which they have been aligned. As a result, the database is not only a database of aligned sequence families, but also a database of implied secondary and tertiary structures covering 29% of all SwissProt-stored sequences. [less ▲]

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See detailMythos Menalk? Neue Fragen zu Pestalozzis Jugend
Tröhler, Daniel UL

in Neue Pestalozzi-Blätter (1997), 3(2), 24-27

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See detailEffects of estrogen on skeletal myoblast growth.
Kahlert, S.; Grohe, C.; Karas, R. H. et al

in Biochemical and biophysical research communications (1997), 232(2), 373-8

To determine the role of estrogen in skeletal muscle growth, we investigated estrogen receptor-mediated effects on proliferation in skeletal myoblasts. In L6, C2C12 and Sol8 myoblasts estrogen receptor ... [more ▼]

To determine the role of estrogen in skeletal muscle growth, we investigated estrogen receptor-mediated effects on proliferation in skeletal myoblasts. In L6, C2C12 and Sol8 myoblasts estrogen receptor was demonstrated by immunoblotting, immunofluorescence microscopy and transfection studies. Estrone induced a significant increase in myoblast growth whereas 17 beta-estradiol had no effect. Furthermore in L6-cells estrone (c-fos: 3.9-fold, egr-1: 4.6-fold) induced immediate-early gene induction significantly stronger than 17 beta-estradiol (c-fos: 1.7-fold, egr-1: 2.3-fold; p < 0.05). Skeletal myoblasts express functional estrogen receptors. Estrogens differ in the activation of skeletal myoblast growth and immediate-early gene induction. [less ▲]

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See detailCharacterization of new proteins found by analysis of short open reading frames from the full yeast genome
Andrade, M. A.; Daruvar, A.; Casari, G. et al

in Journal of Yeast and Fungal Research (1997), 13(14), 1363-1374

We have analysed short open reading frames (between 150 and 300 base pairs long) of the yeast genome (Saccharomyces cerevisiae) with a two-step strategy. The first step selects a candidate set of open ... [more ▼]

We have analysed short open reading frames (between 150 and 300 base pairs long) of the yeast genome (Saccharomyces cerevisiae) with a two-step strategy. The first step selects a candidate set of open reading frames from the DNA. sequence based on statistical evaluation of DNA and protein sequence properties. The second step filters the candidate set by selecting open reading frames with high similarity to other known sequences (from any organism). As a result, we report ten new predicted proteins not present in the current sequence databases. These include a new alcohol dehydrogenase, a protein probably related to the cell cycle, as well as a homolog of the prokaryotic ribosomal protein L36 likely to be a mitochondrial ribosomal protein coded in the nuclear genome. We conclude that the analysis of short open reading frames leads to biologically interesting discoveries, even though the quantitative yield of new proteins is relatively low. [less ▲]

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See detailDe toekomst van de historische pedagogiek.
Selten, P. J. H.; Bakker, P. C. M.; Biesta, Gert UL

in Comenius (1997), 17(3), 195-199

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See detailPax genes and organogenesis.
Dahl, E.; Koseki, H.; Balling, Rudi UL

in BioEssays (1997), 19(9), 755-65

Pax genes are a family of developmental control genes that encode nuclear transcription factors. They are characterized by the presence of the paired domain, a conserved amino acid motif with DNA-binding ... [more ▼]

Pax genes are a family of developmental control genes that encode nuclear transcription factors. They are characterized by the presence of the paired domain, a conserved amino acid motif with DNA-binding activity. Originally, paired-box-containing genes were detected in Drosophila melanogaster, where they exert multiple functions during embryogenesis. In vertebrates, Pax genes are also involved in embryogenesis. Mutations in four out of nine characterized Pax genes have been associated with either congenital human diseases such as Waardenburg syndrome (PAX3), Aniridia (PAX6), Peter's anomaly (PAX6), renal coloboma syndrome (PAX2) or spontaneous mouse mutants (undulated (Pax1), Splotch (Pax3), Small eye (Pax6), Pax2(1)Neu), which all show defects in development. Recently, analysis of spontaneous and transgenic mouse mutants has revealed that vertebrate pax genes are key regulators during organogenesis of kidney, eye, ear, nose, limb muscles, vertebral column and brain. Like their Drosophila counterparts, vertebrate Pax genes are involved in pattern formation during embryogenesis, possibly by determining the time and place of organ initiation or morphogenesis. For most tissues, however, the nature of the primary developmental action of Pax transcription factors remains to be elucidated. One predominant theme is signal transduction during tissue interactions, which may lead to a position-specific regulation of cell proliferation. [less ▲]

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See detailGeometry-dependent scattering through ballistic microstructures: Semiclassical theory beyond the stationary-phase approximation
Wirtz, Ludger UL; Tang, J. Z.; Burgdorfer, J.

in Physical Review. B (1997), 56(12), 7589-7597

The conductance of a ballistic microstructure shows strong fluctuations as a function of the Fermi wave number. We present a semiclassical-theory that describes these fluctuations in terms of bundles of ... [more ▼]

The conductance of a ballistic microstructure shows strong fluctuations as a function of the Fermi wave number. We present a semiclassical-theory that describes these fluctuations in terms of bundles of short trajectories. These trajectories provide the dominant contribution to electron transport through a weakly open microstructure. For the coupling between the quantum wires and the cavity, contributions beyond the stationary phase approximation are taken into account giving rise to diffraction effects. A comparison with full quantum calculations for st rectangular billiard is made. The peak positions of the power spectrum agree very well between the quantum and semiclassical theories. Numerical evidence is found for the breakdown of the semiclassical approximation for long paths. A simple explanation in terms of the dispersion of the semiclassical wave packet in the interior of the cavity is proposed. [less ▲]

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See detailCustomization of System Software for Large-scale Embedded Applications
Nehmer, Jürgen; Sturm, Peter; Baentsch, Michael et al

in Computer Communications (1997), 20

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See detailAccuracy assessment of recent ocean tide models
Shum, C. K.; Woodworth, P. L.; Andersen, O. B. et al

in Journal of Geophysical Research (1997), 102(C11), 25173-25194

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See detailWas ist bei Vorhofflimmern zu beachten?
Neyses, Ludwig UL; Pelzer, T; Maas, A et al

in Der Bayerische Internist (1997), (17), 24-29

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See detailSur certains sous-groupes de torsion de Jacobiennes de courbes hyperelliptiques de genre g > 0
Leprévost, Franck UL

in Manuscripta Mathematica (1997), 92(I), 47-63

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See detailLire les "Recherches" de Pestalozzi
Tröhler, Daniel UL

in Bulletin du Centre de Documentation et de Recherche Pestalozzi (1997), (22), 24-28

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See detailSuperheavy nuclei in self-consistent nuclear calculations
Rutz, C.; Bender, M.; Burvenich, T. et al

in Physical Review. C, Nuclear Physics (1997), 56(1), 238-243

The shell structure of superheavy nuclei is investigated within various parametrizations of relativistic and nonrelativistic nuclear mean-field models. The heaviest known even-even nucleus 156 264Hs108 is ... [more ▼]

The shell structure of superheavy nuclei is investigated within various parametrizations of relativistic and nonrelativistic nuclear mean-field models. The heaviest known even-even nucleus 156 264Hs108 is used as a benchmark to estimate the predictive value of the models. From that starting point, doubly magic spherical nuclei are searched in the region Z51102140 and N5134–298. They are found at (Z5114 , N5184), (Z5120 , N5172), or at (Z5126 , N5184), depending on the parametrization. [less ▲]

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See detailColor-Sensitive Photodetector Based on Porous Silicon Superlattices
Krüger, M.; Marso, Michel UL; Berger, M. G. et al

in Thin Solid Films (1997), 297(1997), 241-244

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See detail« Pierre Klossowski: voyeurisme en theofanie»
Roelens, Nathalie UL

in ALW-Cahier (1997)

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See detailCapacity Utilization and Market Power
Fagnart, J.F.; Licandro, O.; Sneessens, Henri UL

in Journal of Economic Dynamics and Control (1997), 22

We propose a theoretical macroeconomic model where capacity underutilization follows from idiosyncratic demand uncertainty at the time monopolistic firms must choose their productive capacity. After their ... [more ▼]

We propose a theoretical macroeconomic model where capacity underutilization follows from idiosyncratic demand uncertainty at the time monopolistic firms must choose their productive capacity. After their investment decision, firms facing a low demand will typically prefer to run excess capacities rather than reduce their profit margin; firms at full capacity will respond to demand fluctuations solely by price adjustments. We show that the proportion of firms with idle capacities influences crucially the short-run response of the economy to exogenous disturbances and, in particular, the relative importance of price and quantity adjustments. [less ▲]

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See detailTrends in service delivery: Psychological practice in rehabilitation settings
Pit-Ten Cate, Ineke UL; Padrone, Frank; Feinblatt, Arlene et al

in Rehabilitation Outllook (1997)

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See detailSequence analysis of the Methanococcus jannaschii genome and the prediction of protein function
Andrade, M.; Casari, G.; deDaruvar, A. et al

in Computer Applications in the Biosciences [=CABIOS] (1997), 13(4), 481-483

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See detailColor-Sensistive Si-Photodiode Using Porous Silicon Interference Filters
Krüger, M.; Berger, M. G.; Marso, Michel UL et al

in Japanese Journal of Applied Physics (1997), 36(1997), 24-26

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See detailTraditionsbewusstsein - eine wenig beachtete Grundhaltung
Tröhler, Daniel UL

in Infos und Akzente (1997), (17), 11-14

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See detailPhases and phase transitions of KPF6
Huber, P.; Krummeck, H.; Baller, Jörg UL et al

in Ferroelectrics (1997), 203(1), 211-219

Potassium hexafluorophosphate KPF6 has been investigated by X-ray powder diffraction, calorimetry and Brillouin spectroscopy. With decreasing temperature, the crystal shows a sequence of phases: NaCl-type ... [more ▼]

Potassium hexafluorophosphate KPF6 has been investigated by X-ray powder diffraction, calorimetry and Brillouin spectroscopy. With decreasing temperature, the crystal shows a sequence of phases: NaCl-type cubic-monoclinic-monoclinic with two-phase coexistence regions in between. In the cubic phase the elastic constants have been determined. c44 and c12 show a slight softening. [less ▲]

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See detail0.1 µm T-gate Al-free InP/InGaAs/InP pHEMTs for W-Band Applications Using a Nitrogen Carrier for LP-MOCVD Growth
Schimpf, K.; Sommer, M.; Horstmann, M. et al

in IEEE Electron Device Letters (1997), 18

We report on the dc and RF performance of HEMT’s based on the Al-free material system InP/InGaAs/InP. These structures were grown by LP-MOCVD using a nitrogen carrier. The influence of gate length and ... [more ▼]

We report on the dc and RF performance of HEMT’s based on the Al-free material system InP/InGaAs/InP. These structures were grown by LP-MOCVD using a nitrogen carrier. The influence of gate length and channel composition on the performance of these devices is investigated.We demonstrate that optimum dc and RF performance using highly strained channels can be obtained only if additional composite channels are grown. The cutoff frequencies fT =160 GHz and fmax=260 GHz for a 0.1- um T-gate device indicate the suitability of our devices for W-Band applications. [less ▲]

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See detailProcessus de raisonnement et enseignement de l’algèbre au premier degré du secondaire
Vlassis, Joëlle UL; DEMONTY, I

in Informations Pédagogiques (1997), 38

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See detailBespreking van R.V. Arcilla, For the Love of Perfection.
Biesta, Gert UL

in Comenius (1997), 17(2), 168-171

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See detailNote on duopolistic vertical restraints
Irmen, Andreas UL

in European Economic Review (1997), 41(8), 1559-1567

No abstract is available for this item.

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See detailRevêtements de courbes elliptiques à multiplication complexe par des courbes hyperelliptiques et sommes de caractères
Leprévost, Franck UL; Morain, François

in Journal of Number Theory (1997), 64(2), 165-182

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See detailThe nature of the starter unit for the rapamycin polyketide synthase
König, Ariane UL; Schwecke, T.; Molnár, I. et al

in Angewandte Chemie International Edition (1996), 35(19), 2249-2251

A remarkably high level of incorporation is observed when 2,2,5,5-tetradeutero -3,4- dihydroxycyclo -hexanecarboxylic acid is fed to the rapamycin-producing organism. Intriguingly, however, analysis of ... [more ▼]

A remarkably high level of incorporation is observed when 2,2,5,5-tetradeutero -3,4- dihydroxycyclo -hexanecarboxylic acid is fed to the rapamycin-producing organism. Intriguingly, however, analysis of the gene sequence for the rapamycin polyketide synthase has suggested that the free acid may not normally be involved in rapamycin biosynthesis. [less ▲]

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See detailOrganisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of the enzymatic domains in the modular polyketide synthase
Aparicio, J. F.; Molnar, I.; Schwecke, T. et al

in Gene (1996), 169(1), 9-16

The three giant multifunctional polypeptides of the rapamycin (Rp)-producing polyketide synthase (RAPS1, RAPS2 and RAPS3) have recently been shown to contain 14 separate sets, or modules, of enzyme ... [more ▼]

The three giant multifunctional polypeptides of the rapamycin (Rp)-producing polyketide synthase (RAPS1, RAPS2 and RAPS3) have recently been shown to contain 14 separate sets, or modules, of enzyme activities, each module catalysing a specific round of polyketide chain extension. Detailed sequence comparison between these protein modules has allowed further characterisation of aa that may be important in catalysis or specificity. The acyl-carrier protein (ACP), beta-ketoacyl-ACP synthase (KS) and acyltransferase (AT) domains (the core domains) have an extremely high degree of mutual sequence homology. The KS domains in particular are almost perfect repeats over their entire length. Module 14 shows the least homology and is unique in possessing only core domains. The enoyl reductase (ER), beta-ketoacyl-ACP reductase (KR) and dehydratase (DH) domains are present even in certain modules where they are not apparently required. Four DH domains can be recognised as inactive by characteristic deletions in active site sequences, but for two others, and for KR and ER in module 3, the sequence is not distinguishable from that of active counterparts in other modules. The N terminus of RAPS1 contains a novel coenzyme A ligase (CL) domain that activates and attaches the shikimate-derived starter unit, and an ER activity that may modify the starter unit after attachment. The sequence comparison has revealed the surprisingly high sequence similarity between inter-domain 'linker' regions, and also a potential amphipathic helix at the N terminus of each multienzyme subunit which may promote dimerisation into active species. [less ▲]

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See detailOrganisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of the genes flanking the polyketide synthase
Aparicio, J. F.; Molnár, I.; Schwecke, T. et al

in Gene (1996), 169(1), 1-7

The three giant multifunctional polypeptides of the rapamycin (Rp)-producing polyketide synthase (RAPS1, RAPS2 and RAPS3) have recently been shown to contain 14 separate sets, or modules, of enzyme ... [more ▼]

The three giant multifunctional polypeptides of the rapamycin (Rp)-producing polyketide synthase (RAPS1, RAPS2 and RAPS3) have recently been shown to contain 14 separate sets, or modules, of enzyme activities, each module catalysing a specific round of polyketide chain extension. Detailed sequence comparison between these protein modules has allowed further characterisation of aa that may be important in catalysis or specificity. The acyl-carrier protein (ACP), beta-ketoacyl-ACP synthase (KS) and acyltransferase (AT) domains (the core domains) have an extremely high degree of mutual sequence homology. The KS domains in particular are almost perfect repeats over their entire length. Module 14 shows the least homology and is unique in possessing only core domains. The enoyl reductase (ER), beta-ketoacyl-ACP reductase (KR) and dehydratase (DH) domains are present even in certain modules where they are not apparently required. Four DH domains can be recognised as inactive by characteristic deletions in active site sequences, but for two others, and for KR and ER in module 3, the sequence is not distinguishable from that of active counterparts in other modules. The N terminus of RAPS1 contains a novel coenzyme A ligase (CL) domain that activates and attaches the shikimate-derived starter unit, and an ER activity that may modify the starter unit after attachment. The sequence comparison has revealed the surprisingly high sequence similarity between inter-domain 'linker' regions, and also a potential amphipathic helix at the N terminus of each multienzyme subunit which may promote dimerisation into active species. [less ▲]

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See detailZur Eingliederung von Nomen instrumenti im Ripuarischen
Sieburg, Heinz UL

in Germanistik. Publications du Centre Universitaire du Luxembourg. Lettres Allemandes (1996)

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See detail16 GHz Bandwidth MSM Photodetector and 45/85 GHz fT/fmax HEMT Prepared on an Identical InGaAs/InP Layer Structure
Horstmann, M.; Schimpf, K.; Marso, Michel UL et al

in Electronics Letters (1996), 32

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See detailWerteerziehung und pluralistische Gesellschaft
Tröhler, Daniel UL

in Aktuell (1996), (4), 7-10

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See detailDer Einfluss der Motivation auf das Gedächtnis über Personen und die Eindrucksbildung
Krolak-Schwerdt, Sabine UL

in Zeitschrift für experimentelle Psychologie (1996), 43

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See detailMHC-genotyping of IDDM patients in Luxembourg. Evidence for a pediatric patient subgroup.
Hentges, F. R.; Michel, G. H.; Hoffmann, A. J. et al

in Bulletin de la Société des sciences médicales du Grand-Duché de Luxembourg (1996), 133(1), 5-12

[No abstract available]

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See detailPolizei und Fremde. Spezifische Belastungssituationen und die Genese von Feindbildern und Übergriffen
Willems, Helmut UL; Eckert, Roland; Jungbauer, Johannes

in Neue Kriminalpolitik (1996), 8. Jg(Heft 4), 28-32

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See detailWachstum und Wandel: Die «neue» Wachstumstheorie als Theorie wirtschaftlicher Entwicklung
Klump, Rainer UL

in ORDO: Jahrbuch für die Ordnung von Wirtschaft und Gesellschaft (1996)

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See detailEndothelin-1 does not modulate O2.release and [Ca(2+)]i variations in resting or differentiated HL-60 cells
Gallois, A.; Bueb, Jean-Luc UL; Tschirhart, Eric UL

in Fundamental and Clinical Pharmacology (1996), 10(1), 28-32

Endothelin-1 (ET-1) by itself was not an effective stimulus for inducing superoxide (O2.) generation in human resting or DMSO-differentiated neutrophil-like HL-60 cells. ET-1 (0.01-100 nM) was not able to ... [more ▼]

Endothelin-1 (ET-1) by itself was not an effective stimulus for inducing superoxide (O2.) generation in human resting or DMSO-differentiated neutrophil-like HL-60 cells. ET-1 (0.01-100 nM) was not able to modulate O2. generation stimulated by the chemotactic peptide N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP, EC50 = 4.24 +/- 1.63 nM in the absence and 3.16 +/- 1.95 nM in the presence of ET-1). Neither did ET-1 (0.01-100 nM) promote the mobilization of intracellular calcium ions or modulate fMLP-induced [Ca(2+)]i increase in this model of human neutrophils. Phosphoramidon, a neutral endopeptidase inhibitor, was not able to reveal any biological (O2.) or biochemical ([Ca(2+)]i response to ET-1 in the absence or in the presence of fMLP in these cells. These results indicate that DMSO-differentiated neutrophil-like HL-60 cells are not sensitive to ET-1 in terms of O2. generation or [Ca(2+)]i variations. [less ▲]

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See detailThermionic Field Emission in p-Barrier enhanced InP/InGaAs/InP HEMTs
Schimpf, K.; Horstmann, M.; Hardtdegen, H. et al

in Electronics Letters (1996), 32(1996), 2132-2133

A model for thermionic field emission in p-barrier enhanced InP HEMTs is presented indicating that a reduction in the gate leakage of those devices is related to an increase in effective barrier thickness ... [more ▼]

A model for thermionic field emission in p-barrier enhanced InP HEMTs is presented indicating that a reduction in the gate leakage of those devices is related to an increase in effective barrier thickness. Good agreement between this model and our experimental data is obtained. [less ▲]

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See detailInternal Finance and Capital Accumulation in a Dynamic General Equilibrium Model with Credit Constraints
Sneessens, Henri UL; Stefani, Maria Lucia

in Louvain Economic Review - Recherches Economiques de Louvain (1996), 62(2-3), 255-86

Detailed reference viewed: 37 (1 UL)
See detailHauptströmungen und Tendenzen der Schweizer Pestalozzi-Forschung
Tröhler, Daniel UL

in Pädagogische Rundschau (1996), 50(1), 59-74

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See detailAnalysis of limb patterning in BMP-7-deficient mice.
Hofmann, C.; Luo, G.; Balling, Rudi UL et al

in Developmental Genetics (1996), 19(1), 43-50

Bone morphogenetic proteins (BMPs) are polypeptide signaling molecules, belonging to the TGF-beta superfamily. They were originally identified by their ability to induce ectopic bone formation, but their ... [more ▼]

Bone morphogenetic proteins (BMPs) are polypeptide signaling molecules, belonging to the TGF-beta superfamily. They were originally identified by their ability to induce ectopic bone formation, but their expression patterns in embryos suggest multiple functions. BMP-7-deficient mice show among other mesodermal and skeletal patterning defects, polydactyly in the hindlimbs [Luo G, Hofmann C, Bronckers ALJJ, Sohocki M, Bradley A, Karsenty G (1995): Genes Dev 9:2808-2820; Dudley AT, Lyons KM, Robertson EJ (1995): Genes Dev 9:2795-2807]. Here we report a more detailed analysis of the limb phenotype in BMP-7-deficient mice using in situ hybridization to monitor expression of molecules implicated in patterning processes of the developing vertebrate limb. In previous studies we showed that Sonic hedgehog (Shh) was expressed normally, but Hoxd-13 expression in limb mesenchyme was lower in BMP-7 mutant limbs. Here we show that Hoxd-11 expression domains are also contracted and decreased in intensity in mutant limbs, suggesting that 5' genes of the Hoxd cluster are coordinately downregulated, while another Bmp, Bmp-2, which can be activated by Shh, is similarly expressed. The mutant limb buds are broader than normal buds, and fibroblast growth factor Fgf-8 is expressed throughout the extended ridge. However, expression of the homeobox gene Msx-1, which has been shown to be involved in epithelial-mesenchymal interactions during limb development, was decreased in the mesenchyme of BMP-7 mutant limbs. Taken together, our data suggest that BMP-7 is involved in regulating proliferation and/or epithelial-mesenchymal interactions in the developing limb. [less ▲]

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See detailThe Evil of Superefficiency
Stoica, Petre; Ottersten, Björn UL

in Signal Processing (1996), 55(1), 133136

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See detailL’évolution du monde syndical luxembourgeois dans l’entre-deux-guerres
Scuto, Denis UL

in Hemecht : Zeitschrift für Luxemburger Geschichte = Revue d'Histoire Luxembourgeoise (1996)

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See detail«De la colère de l'escargot à la rage de l'expression»
Roelens, Nathalie UL

in C.R.I.N. (1996)

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See detailFermionic anomalies in quantum-mechanical relativistic problems
del Sol Mesa, Antonio UL

in Il Nuovo Cimento (1996)

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See detailA Restriction Theorem for Ideals in the Schwartz Algebra of a Nilpotent Lie Group
Ludwig, Jean; Molitor-Braun, Carine UL

in Archiv der Mathematik [=ADM] (1996), 67(3), 199-210

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