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See detailA single STAT recruitment module in a chimeric cytokine receptor complex is sufficient for STAT activation
Behrmann, Iris UL; Janzen, C.; Gerhartz, C. et al

in Journal of Biological Chemistry (1997), 272(8), 5269-74

We established a system of receptor chimeras that enabled us to induce heterodimerization of different cytoplasmic tails. Fusion constructs were created that are composed of the extracellular parts of the ... [more ▼]

We established a system of receptor chimeras that enabled us to induce heterodimerization of different cytoplasmic tails. Fusion constructs were created that are composed of the extracellular parts of the interleukin-5 receptor alpha and beta chains, respectively, and the transmembrane and intracellular parts of gp130, the signal transducing chain of the interleukin-6 receptor complex. In COS-7 transfectants we observed a dose-dependent interleukin-5-inducible STAT1 activation for which the presence of both the alpha and the beta chain chimera was needed. No STAT activity was detected if one of the cytoplasmic tails of the receptor complex was deleted, indicating that STAT activity resulted from a receptor dimer rather than from higher receptor aggregates. We further investigated whether dimerization of STAT1 depends on the juxtaposition of two STAT recruitment modules in a receptor complex. We show that a receptor dimer with only a single STAT1 docking site was still able to lead to STAT1 activation. This indicates that the formation of a paired set of STAT binding sites in a receptor complex is not the prerequisite for STAT factor dimerization. Our findings are discussed in view of alternative STAT dimerization models. [less ▲]

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See detailDe toekomst van de historische pedagogiek
Bakker,P.C.M.; Selten,P.J.H; Biesta, Gert UL

in Comenius (1997), 17(3), 195-244

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See detailProtein fold recognition by prediction-based threading
Rost, B.; Schneider, Reinhard UL; Sander, C.

in Journal of Molecular Biology (1997), 270(3), 471-480

In fold recognition by threading one takes the amino acid sequence of a protein and evaluates how well it fits into one of the known three-dimensional (3D) protein structures. The quality of sequence ... [more ▼]

In fold recognition by threading one takes the amino acid sequence of a protein and evaluates how well it fits into one of the known three-dimensional (3D) protein structures. The quality of sequence-structure fit is typically evaluated using inter-residue potentials of mean force or other statistical parameters. Here, we present an alternative approach to evaluating sequence-structure fitness. Starting from the amino acid sequence we first predict secondary structure and solvent accessibility for each residue. We then thread the resulting one-dimensional (1D) profile of predicted structure assignments into each of the known 3D structures. The optimal threading for each sequence-structure pair is obtained using dynamic programming. The overall best sequence-structure pair constitutes the predicted 3D structure for the input sequence. The method is fine-tuned by adding information from direct sequence-sequence comparison and applying a series of empirical filters. Although the method relies on reduction of 3D information into 1D structure profiles, its accuracy is, surprisingly, not clearly inferior to methods based on evaluation of residue interactions in 3D. We therefore hypothesise that existing 1D-3D threading methods essentially do not capture more than the fitness of an amino acid sequence for a particular 1D succession of secondary structure segments and residue solvent accessibility. The prediction-based threading method on average finds any structurally homologous region at first rank in 29% of the cases (including sequence information). For the 22% first hits detected at highest scores, the expected accuracy rose to 75%. However, the task of detecting entire folds rather than homologous fragments was managed much better; 45 to 75% of the first hits correctly recognised the fold. [less ▲]

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See detailInvestigation of the Met-267 Arg exchange in isoform 1 of the human plasma membrane calcium pump in patients with essential hypertension by the amplification-created restriction site technique.
Benkwitz, C.; Kubisch, C.; Kraft, K. et al

in Journal of Molecular Medicine (1997), 75(1), 62-6

Alterations in Ca2+ homeostasis have been proposed to be a primary factor in the pathogenesis of essential hypertension. In this disease increased intracellular Ca2+ levels have repeatedly been reported ... [more ▼]

Alterations in Ca2+ homeostasis have been proposed to be a primary factor in the pathogenesis of essential hypertension. In this disease increased intracellular Ca2+ levels have repeatedly been reported in various cell types. Because of its prominent role in cellular calcium homeostasis in vascular smooth muscle cells, modifications of the plasma membrane Ca2+-ATPase (PMCA) pump have been suggested to contribute to an increased contractile tone of small blood vessels. This pump is a calmodulin-dependent Ca2+-ATPase that ejects Ca2+ from the cytosol into the extracellular space. Recently a mutational thymidine (T)-->guanosine (G) transversion in isoform 1 of the PMCA has been identified resulting in the substitution of a methionine (Met) by an arginine (Arg) at amino acid position 267 in a highly conserved domain of the pump molecule. The aim of our study was to determine the prevalence of this polymorphism in the normal population and to investigate whether the Met-267 Arg occurs more frequently in patients with essential hypertension than in normotensives. To detect the mutational change we modified a method based on the technique of amplification-created restriction sites (ACRS) using three base exchanges in the diagnostic primer. Samples from 100 hypertensive and 60 normotensive subjects revealed a thymidine at nucleotide position 981. These data suggest that ACRS is feasible in spite of extensive primer modifications (e.g., three mismatched bases) in contrast to the previously used one or two and may therefore be conceptually suitable to detect almost any base changes in the genome. The described T-->G transversion is a rare polymorphism and is presumably not related to common forms of essential hypertension. [less ▲]

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See detailReview of: George Lakoff. Moral Politics
Weber, Jean-Jacques UL

in BELL. Belgian Journal of English Language and Literatures (1997), 6

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See detailSur certains sous-groupes de torsion de Jacobiennes de courbes hyperelliptiques de genre g > 0
Leprévost, Franck UL

in Manuscripta Mathematica (1997), 92(I), 47-63

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See detailSurface-induced organization of linear molecules on nanostructured polytetrafluoroethylene: Crystalline state of poly[vinylidenefluoride-trifluoroethylene].
Krüger, Jan-Kristian UL; Heydt, B.; Fischer, C. et al

in Physical Review. B, Condensed Matter and Materials Physics (1997), 55(6), 3497-3506

Highly crystalline and uniaxial-oriented polytetrafluoroethylene films, nanostructured in one dimension, were used to produce a fully crystalline, thermoreversible morphology in the ferroelectric ... [more ▼]

Highly crystalline and uniaxial-oriented polytetrafluoroethylene films, nanostructured in one dimension, were used to produce a fully crystalline, thermoreversible morphology in the ferroelectric copolymer poly[vinylidenefluoride-trifluoroethylene]. The resulting state is built up of regularly stacked lamellar crystals of about 100 nm thickness and lateral dimensions of about 6 μm. [less ▲]

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See detailChocolate City -­‐ Vanilla Suburbs. Eine Reise in Vergangenheit und Zukunft des Städtischen
Hesse, Markus UL

in Kommune: Forum für Politik, Ökonomie, Kultur (1997), 15(2), 56-59

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See detailHierarchy of Norms in European Community Law
Hofmann, Herwig UL; Weiler, J. H. H.; Ballmann, Alexander et al

in Certain Rectangular Problems of European Integration (1997), II(Project IV/95/02),

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See detailCardiac myocytes and fibroblasts contain functional estrogen receptors.
Grohe, C.; Kahlert, S.; Lobbert, K. et al

in FEBS letters (1997), 416(1), 107-12

Gender-based differences found in cardiovascular diseases raise the possibility that estrogen may have direct effects on cardiac tissue. Therefore we investigated whether cardiac myocytes and fibroblasts ... [more ▼]

Gender-based differences found in cardiovascular diseases raise the possibility that estrogen may have direct effects on cardiac tissue. Therefore we investigated whether cardiac myocytes and fibroblasts express functional estrogen receptors. Immunofluorescence demonstrated estrogen receptor protein expression in both female and male rat cardiac myocytes and fibroblasts. Nuclear translocation of the estrogen receptor protein was observed after stimulation of cardiomyocytes with 17beta-estradiol (E2). Cells transfected with an estrogen-responsive reporter plasmid showed that treatment with E2 induced a significant increase in reporter activity. Furthermore, E2 induced a significant increase in expression of the estrogen receptors alpha and beta, progesterone receptor and connexin 43 in cardiac myocytes. Cardiac myocytes and fibroblasts contain functional estrogen receptors and estrogen regulates expression of specific cardiac genes. These data suggest that gender-based differences in cardiac diseases may in part be due to direct effects of estrogen on the heart. [less ▲]

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See detailWas ist bei Vorhofflimmern zu beachten?
Neyses, Ludwig UL; Pelzer, T; Maas, A et al

in Der Bayerische Internist (1997), (17), 24-29

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See detailSpace-charge controlled conduction in low-temperature-grown molecular-beam epitaxial GaAs,
Kordoš, P.; Marso, Michel UL; Förster, A. et al

in Applied Physics Letters (1997), 71

Current transport in low-temperature (LT) molecular-beam epitaxial GaAs grown at 200-300 °C on an n+ GaAs substrate is studied by means of current–voltage–temperature characteristics. The resistivity of ... [more ▼]

Current transport in low-temperature (LT) molecular-beam epitaxial GaAs grown at 200-300 °C on an n+ GaAs substrate is studied by means of current–voltage–temperature characteristics. The resistivity of LT GaAs at low electric fields is rho>108 Ohm cm, much higher than resulting from van der Pauw measurements. It is found that the measured resistivity decreases with increasing the LT GaAs thickness. This is explained by space-charge effect in the vicinity of n+/LT GaAs junction and subsequent suppression of hopping conduction in the high-field junction region. [less ▲]

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See detailEditorial
Tröhler, Daniel UL

in Neue Pestalozzi-Blätter (1997), 3(2), 1-1

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See detailEnhancing the Web's infrastructure: from caching to replication
Baentsch, Michael; Baum, Lothar; Molter, Georg et al

in IEEE Internet Computing (1997), 1(2), 18-27

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See detailGezin en moraal
Doornenbal,J.; Biesta, Gert UL; Heyting,G.F.

in Comenius (1997), 17(4), 275-324

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See detailSuperheavy nuclei in self-consistent nuclear calculations
Rutz, C.; Bender, M.; Burvenich, T. et al

in Physical Review. C : Nuclear Physics (1997), 56(1), 238-243

The shell structure of superheavy nuclei is investigated within various parametrizations of relativistic and nonrelativistic nuclear mean-field models. The heaviest known even-even nucleus 156 264Hs108 is ... [more ▼]

The shell structure of superheavy nuclei is investigated within various parametrizations of relativistic and nonrelativistic nuclear mean-field models. The heaviest known even-even nucleus 156 264Hs108 is used as a benchmark to estimate the predictive value of the models. From that starting point, doubly magic spherical nuclei are searched in the region Z51102140 and N5134–298. They are found at (Z5114 , N5184), (Z5120 , N5172), or at (Z5126 , N5184), depending on the parametrization. [less ▲]

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See detailEtude de differentes methodes pour la mise en evidence des autoanticorps anti-glutamate-decarboxylase associes au developpement du diabete insulinodependant
Humbel, R. L.; Guillaume, A. C.; Schmit, P. et al

in Immuno-Analyse et Biologie Specialisee (1997), 12(5), 275-279

Autoantibodies to glutamate-decarboxylase (GAD) are present in the serum of patients with insulin dependent diabetes (DID) even before the development of the overt diabetes. These antibodies react ... [more ▼]

Autoantibodies to glutamate-decarboxylase (GAD) are present in the serum of patients with insulin dependent diabetes (DID) even before the development of the overt diabetes. These antibodies react predominantly with the native GAD. Various methods have been studied (radio immunoassay [RIA] and enzyme- linked immunosorbent assay [ELISA]). It was observed that at the present time only RIA-tests, in which GAD is presented in fluid phase, are able to detect antibodies. [less ▲]

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See detailAlter Wein in neuen Schläuchen? Agenda 21 und Stadtentwicklung -
Hesse, Markus UL

in Politische Ökologie : die Reihe für Querdenker und Vordenkerinnen (1997), (52), 38-41

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See detailRetrospektive Bewertungen des eigenen Lebens: LZG – Lebenszufriedenheits-Graph.
Ferring, Dieter UL; Filipp, Sigrun-Heide

in Zeitschrift für Entwicklungspsychologie und Padagogische Psychologie (1997), 29(1)

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See detailRapid identification of measles virus strains by the heteroduplex mobility assay
Kreis, Stephanie UL; Whistler, T.

in Virus Research (1997), 47(2), 472197-203

The continued endemic presence of measles virus (MV), and the large number of isolates which are made in South Africa each year, demanded the use of a rapid and reliable pre-screening technique to select ... [more ▼]

The continued endemic presence of measles virus (MV), and the large number of isolates which are made in South Africa each year, demanded the use of a rapid and reliable pre-screening technique to select isolates for molecular epidemiological studies by sequence analysis. The heteroduplex mobility assay (HMA) was used to genetically characterize 47 MV isolates collected from three different provinces in South Africa, made between 1986 and 1995. The carboxyl-terminal 590 nt of the nucleocapsid (N) gene - the most variable region of the genome - was amplified by polymerase chain reaction (PCR) and subsequently subjected to HMA analysis for initial genotyping. The results showed three different patterns of heteroduplex formation by gel electrophoresis, representing two distinct wild-type lineages and one group of vaccine-like viruses. Comparison of HMA results with phylogenetic analysis of sequence data for several of the South African MV strains showed a complete correlation of results. The HMA proved to be a useful tool for screening MV isolates for use in molecular epidemiological studies. [less ▲]

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See detailSelbstbewertungen und selektive Präferenz für temporale vs. Soziale Vergleichsinformation bei alten und sehr alten Menschen.
Filipp, Sigrun-Heide; Ferring, Dieter UL; Mayer, Anne-Kathrin et al

in Zeitschrift für Sozialpsychologie (1997)

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See detailCharacterization of new proteins found by analysis of short open reading frames from the full yeast genome
Andrade, M. A.; Daruvar, A.; Casari, G. et al

in Journal of Yeast and Fungal Research (1997), 13(14), 1363-1374

We have analysed short open reading frames (between 150 and 300 base pairs long) of the yeast genome (Saccharomyces cerevisiae) with a two-step strategy. The first step selects a candidate set of open ... [more ▼]

We have analysed short open reading frames (between 150 and 300 base pairs long) of the yeast genome (Saccharomyces cerevisiae) with a two-step strategy. The first step selects a candidate set of open reading frames from the DNA. sequence based on statistical evaluation of DNA and protein sequence properties. The second step filters the candidate set by selecting open reading frames with high similarity to other known sequences (from any organism). As a result, we report ten new predicted proteins not present in the current sequence databases. These include a new alcohol dehydrogenase, a protein probably related to the cell cycle, as well as a homolog of the prokaryotic ribosomal protein L36 likely to be a mitochondrial ribosomal protein coded in the nuclear genome. We conclude that the analysis of short open reading frames leads to biologically interesting discoveries, even though the quantitative yield of new proteins is relatively low. [less ▲]

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See detailSolarthermische Energie in Andalusien - Hindernisse bei der Nutzung eines endogenen Potentials
Helfer, Malte UL

in Geographische Rundschau (1997), 49(6), 348-354

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See detailIsolation of the Pax9 cDNA from adult human esophagus.
Peters, H.; Schuster, G.; Neubuser, A. et al

in Mammalian Genome (1997), 8(1), 62-4

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See detailQuantification of wild-type mitochondrial DNA and its 4.8-kb deletion in rat organs.
Filser, N.; Margue, Christiane UL; Richter, C.

in Biochemical and biophysical research communications (1997), 233(1), 102-7

Oxidative damage to mitochondrial DNA (mtDNA) is considered a major contributor in aging. An age-dependent increase of oxidative damage and of the quantity of partially deleted mtDNA was reported for ... [more ▼]

Oxidative damage to mitochondrial DNA (mtDNA) is considered a major contributor in aging. An age-dependent increase of oxidative damage and of the quantity of partially deleted mtDNA was reported for several rat and human organs. Here, a systematic investigation of ten different tissues and organs of 20-months-old rats was performed. The amount of mtDNA and age-dependent 4.8 kb deletion (delta mtDNA4834) was determined by competitive polymerase chain reaction, along with the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSHPx). The data were related to the corresponding metabolic rates. MtDNA content was highest in heart and lowest in spleen. delta mtDNA4834 was detected in all ten tissues and organs, and its amount was highest in liver and lowest in intestine. In heart, lung, muscle, and bone-marrow the deletion could not be quantified because of a point mutation, an A-->T transition at position 8107. Activities of SOD and GSHPx were highest in liver and lowest in intestinal mucosa. A negative correlation between mtDNA content and delta mtDNA4834, and a positive correlation between metabolic rate, GSHPx, and the deletion was found. These results suggest that the occurrence of delta mtDNA4834 in rat is related to oxidative stress. [less ▲]

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See detailQuantitative examination of calcitonin gene-related peptide immunoreactive nerve fibers in the cat knee joint capsule
Heppelmann, Bernd; Shahbazian, Zarah; Hanesch, Ulrike UL

in Anatomy & Embryology (1997), 195

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See detailThe HSSP database of protein structure-sequence alignments
Schneider, Reinhard UL; deDaruvar, A.; Sander, C.

in Nucleic Acids Research (1997), 25(1), 226-230

HSSP is a derived database merging structural (3-D) and sequence (1-D) information. For each protein of known 3-D structure from the Protein Data Bank (PDB), the database has a multiple sequence alignment ... [more ▼]

HSSP is a derived database merging structural (3-D) and sequence (1-D) information. For each protein of known 3-D structure from the Protein Data Bank (PDB), the database has a multiple sequence alignment of all available homologues and a sequence profile characteristic of the family. The list of homologues is the result of a database search in SwissProt using a position-weighted dynamic programming method for sequence profile alignment (MaxHom). The database is updated frequently. The listed homologues are very likely to have the same 3-D structure as the PDB protein to which they have been aligned. As a result, the database is not only a database of aligned sequence families, but also a database of implied secondary and tertiary structures covering 29% of all SwissProt-stored sequences. [less ▲]

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See detailColor-Sensistive Si-Photodiode Using Porous Silicon Interference Filters
Krüger, M.; Berger, M. G.; Marso, Michel UL et al

in Japanese Journal of Applied Physics (1997), 36(1997), 24-26

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See detailMaximum Likelihood Array Processing in Spatially Correlated Noise Fields Using Parametrized Signals
Viberg, Mats; Stoica, Petre; Ottersten, Björn UL

in IEEE Transactions on Signal Processing (1997), 45(4), 9961004

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See detailRezension des Artikels: Neuere Forschungsarbeiten zur Kontaktlinguistik (Plurilingua XIX) von Moelleken, WW. & Weber P.J.
Hu, Adelheid UL

in Tertium Comparationis. Journal für Internationale Bildungsforschung (1997), 4(1), 71-73

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See detailAnger suppression, reactivity and hypertension risk: Gender makes a difference
Vögele, Claus UL; Cheeseman, Karen; Jarvis, Ann

in Annals of Behavioral Medicine : A Publication of the Society of Behavioral Medicine (1997), 19

The present study investigated gender-related differences in cardiovascular reactivity and the role of anger inhibition and risk for future hypertension. Tonic blood pressure served as an index of ... [more ▼]

The present study investigated gender-related differences in cardiovascular reactivity and the role of anger inhibition and risk for future hypertension. Tonic blood pressure served as an index of hypertension risk. Twenty-eight female and 26 male college students with high and low normal blood pressure were recruited on the basis of their mean arterial pressure. Continuous measures of heart rate and blood pressure were taken while participants carried out a series of behavioral manoeuvres including mental arithmetic, interpersonal challenge, a frustrating psychomotor test, and the cold pressor test. Participants also completed inventories assessing trait anxiety, trait anger, anger expression, and Type A. The results are in concordance with previous findings and show higher cardiovascular reactivity in men than in women and in subjects at risk for hypertension. Within the male group, a combination of hypertension risk and anger suppression led to the highest reactivity, whereas in female subjects, differences in anger-in had no effect on reactivity. The implications of these results are discussed in light of sex differences in cardiovascular morbidity and mortality. [less ▲]

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See detailColor-Sensitive Photodetector Based on Porous Silicon Superlattices
Krüger, M.; Marso, Michel UL; Berger, M. G. et al

in Thin Solid Films (1997), 297(1997), 241-244

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See detailPhases and phase transitions of KPF6
Huber, P.; Krummeck, H.; Baller, Jörg UL et al

in Ferroelectrics (1997), 203(1), 211-219

Potassium hexafluorophosphate KPF6 has been investigated by X-ray powder diffraction, calorimetry and Brillouin spectroscopy. With decreasing temperature, the crystal shows a sequence of phases: NaCl-type ... [more ▼]

Potassium hexafluorophosphate KPF6 has been investigated by X-ray powder diffraction, calorimetry and Brillouin spectroscopy. With decreasing temperature, the crystal shows a sequence of phases: NaCl-type cubic-monoclinic-monoclinic with two-phase coexistence regions in between. In the cubic phase the elastic constants have been determined. c44 and c12 show a slight softening. [less ▲]

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See detailMeasles virus transmission from infected to immune individuals - Implications for measles control and elimination
Vardas, E.; Andre, M.; Kreis, Stephanie UL et al

in South African Medical Journal (1997), 87(12), 1709

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See detailSuperheavy nuclei in selfconsistent nuclear calculations
Rutz, K.; Bender, M.; Bürvenich, T. et al

in AIP Conference Proceedings (1997), 56(1), 238-243

The shell structure of superheavy nuclei is investigated within various parametrizations of relativistic and nonrelativistic nuclear mean-field models. The heaviest known even-even nucleus 156 264Hs108 is ... [more ▼]

The shell structure of superheavy nuclei is investigated within various parametrizations of relativistic and nonrelativistic nuclear mean-field models. The heaviest known even-even nucleus 156 264Hs108 is used as a benchmark to estimate the predictive value of the models. From that starting point, doubly magic spherical nuclei are searched in the region Z51102140 and N5134–298. They are found at (Z5114 , N5184), (Z5120 , N5172), or at (Z5126 , N5184), depending on the parametrization. [less ▲]

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See detailA Return to the Dewey-Russell Opposition.
Biesta, Gert UL

in [Review Essay] Culture & Psychology (1997), 3(1), 99-105

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See detailAnalysis of Subspace System Identification Methods Based on Instrumental Variables and Subspace Fitting
Viberg, Mats; Wahlberg, Bo; Ottersten, Björn UL

in Automatica (1997), 33

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See detailEffects of an acute inflammation on the proportion of CGRP- and SP-containing joint afferents
Hanesch, Ulrike UL; Heppelmann, Bernd

in Neuroscience Letters (1997), 233

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See detailMark-up pricing and bilateral monopoly
Irmen, Andreas UL

in Economics Letters (1997), 54(2), 179-184

It is an empirically established fact that managers use cost based percentage margins when they price their goods. As a consequence, percentage mark-ups should be determined as equilibrium choices. This ... [more ▼]

It is an empirically established fact that managers use cost based percentage margins when they price their goods. As a consequence, percentage mark-ups should be determined as equilibrium choices. This paper incorporates this empirical observation into the analysis of competition among bilateral monopolists. [less ▲]

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See detailActions exponentielles et noyaux d'opérateurs
Molitor-Braun, Carine UL

in Travaux Mathématiques (1997), 9

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See detailSupermultiplicity and the relativistic coulomb problem with arbitrary spin
del Sol Mesa, Antonio UL

in Foundations of Physics (1997)

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See detailCalcitonin gene-related peptide- and substance P-like immunoreactive fibers in the spermatic nerve and testis of the dog.
Tamura, Ryoko; Hanesch, Ulrike UL; Schmidt, Robert et al

in Neuroscience Letters (1997), 235

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See detailNote on duopolistic vertical restraints
Irmen, Andreas UL

in European Economic Review (1997), 41(8), 1559-1567

No abstract is available for this item.

Detailed reference viewed: 109 (1 UL)
See detailGezin en moraal: Gezinsopvoeding als het morele fundament van de samenleving?
Doornenbal, J.; Heyting, G. F.; Biesta, Gert UL

in Comenius (1997), 17(4), 275-280

Detailed reference viewed: 35 (0 UL)
See detailDe toekomst van de historische pedagogiek.
Selten, P. J. H.; Bakker, P. C. M.; Biesta, Gert UL

in Comenius (1997), 17(3), 195-199

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See detailPax genes and organogenesis.
Dahl, E.; Koseki, H.; Balling, Rudi UL

in BioEssays (1997), 19(9), 755-65

Pax genes are a family of developmental control genes that encode nuclear transcription factors. They are characterized by the presence of the paired domain, a conserved amino acid motif with DNA-binding ... [more ▼]

Pax genes are a family of developmental control genes that encode nuclear transcription factors. They are characterized by the presence of the paired domain, a conserved amino acid motif with DNA-binding activity. Originally, paired-box-containing genes were detected in Drosophila melanogaster, where they exert multiple functions during embryogenesis. In vertebrates, Pax genes are also involved in embryogenesis. Mutations in four out of nine characterized Pax genes have been associated with either congenital human diseases such as Waardenburg syndrome (PAX3), Aniridia (PAX6), Peter's anomaly (PAX6), renal coloboma syndrome (PAX2) or spontaneous mouse mutants (undulated (Pax1), Splotch (Pax3), Small eye (Pax6), Pax2(1)Neu), which all show defects in development. Recently, analysis of spontaneous and transgenic mouse mutants has revealed that vertebrate pax genes are key regulators during organogenesis of kidney, eye, ear, nose, limb muscles, vertebral column and brain. Like their Drosophila counterparts, vertebrate Pax genes are involved in pattern formation during embryogenesis, possibly by determining the time and place of organ initiation or morphogenesis. For most tissues, however, the nature of the primary developmental action of Pax transcription factors remains to be elucidated. One predominant theme is signal transduction during tissue interactions, which may lead to a position-specific regulation of cell proliferation. [less ▲]

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See detailEffects of estrogen on skeletal myoblast growth.
Kahlert, S.; Grohe, C.; Karas, R. H. et al

in Biochemical and biophysical research communications (1997), 232(2), 373-8

To determine the role of estrogen in skeletal muscle growth, we investigated estrogen receptor-mediated effects on proliferation in skeletal myoblasts. In L6, C2C12 and Sol8 myoblasts estrogen receptor ... [more ▼]

To determine the role of estrogen in skeletal muscle growth, we investigated estrogen receptor-mediated effects on proliferation in skeletal myoblasts. In L6, C2C12 and Sol8 myoblasts estrogen receptor was demonstrated by immunoblotting, immunofluorescence microscopy and transfection studies. Estrone induced a significant increase in myoblast growth whereas 17 beta-estradiol had no effect. Furthermore in L6-cells estrone (c-fos: 3.9-fold, egr-1: 4.6-fold) induced immediate-early gene induction significantly stronger than 17 beta-estradiol (c-fos: 1.7-fold, egr-1: 2.3-fold; p < 0.05). Skeletal myoblasts express functional estrogen receptors. Estrogens differ in the activation of skeletal myoblast growth and immediate-early gene induction. [less ▲]

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See detailAccuracy assessment of recent ocean tide models
Shum, C. K.; Woodworth, P. L.; Andersen, O. B. et al

in Journal of Geophysical Research (1997), 102(C11), 25173-25194

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See detailBespreking van R.V. Arcilla, For the Love of Perfection.
Biesta, Gert UL

in Comenius (1997), 17(2), 168-171

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See detailFluctuations in GAD65 antibodies after clinical diagnosis of IDDM in young children
Batstra, M. R.; Pina, M.; Quan, J. et al

in Diabetes Care (1997), 20(4), 642-644

OBJECTIVE - To investigate whether the presence of GAD antibodies at onset of IDDM correlates to a more aggressive rate of β-cell destruction after clinical onset. RESEARCH DESIGN AND METHODS - We studied ... [more ▼]

OBJECTIVE - To investigate whether the presence of GAD antibodies at onset of IDDM correlates to a more aggressive rate of β-cell destruction after clinical onset. RESEARCH DESIGN AND METHODS - We studied GAD antibodies at onset of disease, after 1 year, and after 6 years in 33 consecutively referred children (mean age 8.08, range 1.7-16.3). In a subset of 11 patients, GAD antibodies were studied very frequently. The correlation between GAD antibodies and clinical parameters, including glycosylated hemoglobin, residual insulin secretion, and insulin dosage, was evaluated. RESULTS - GAD antibody titers were highly variable. Four patients became GAD antibody positive weeks to years after clinical onset. Other patients switched between testing positive and negative for GAD antibodies shortly after clinical onset. No correlation was found between the presence of GAD antibodies and the rate of β-cell destruction, but patients with high GAD antibody indexes at onset had significantly higher glycosylated hemoglobin levels. CONCLUSIONS - GAD antibodies at clinical onset do not predict the rate of β-cell destruction in young children with newly diagnosed IDDM. The highly variable GAD antibody levels suggest variation of the autoimmune process. [less ▲]

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See detailOnmogelijke opvoeding. Kanttekeningen bij de pedagogische overdrachtsmetafoor.
Biesta, Gert UL

in Comenius (1997), 17(4), 312-324

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See detailUne caractérisation différentielle des points de Weierstrass généralisés d'une surface de Riemann compacte de genre g > 1
Leprévost, Franck UL

in Journal de Mathématiques Pures et Appliquées (1997), 76

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See detailSchule und Sport aus der Sicht jugendlicher Vereinsmitglieder - ein internationaler Vergleich
Steffgen, Georges UL; Schwenkmezger, Peter; Fröhling, Roland

in Sportunterricht (1997), 46(7), 292-300

The findings are presented of an international comparative study of youth sports club members to determine their perspectives on the relationship between school and sport, and the influence of physical ... [more ▼]

The findings are presented of an international comparative study of youth sports club members to determine their perspectives on the relationship between school and sport, and the influence of physical education on sport participation and membership of sports clubs. Participants in the study comprised two groups of 344 sports club members and school pupils from Luxembourg and Germany. Differences in terms of age, sex and school type were taken into account. The main findings indicate that school and physical education in both countries only have a slight, indirect influence on young people's decisions to become members of sports clubs and participate in sport. Indeed, the pressures of school may in some cases be an obstacle to intensive sports activity and training outside school. This is particularly so in Luxembourg where students often have to refuse participation in sports competitions and training because of the pressures of school work. Some final thoughts are presented on ways in which school and physical education could become more supportive of youth sport training and club membership, and could give greater encouragement to young people to succeed in competitive and high level sport. [less ▲]

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See detailHuman umbilical cord blood-derived eosinophils cultured in the presence of IL-3 and IL-5 respond to fMLP with [Ca2+]i variation and O2- production
Zardini, D. M.; Heuschling, Paul UL; Gallois, A. et al

in Journal of Immunological Methods (1997), 205(1), 1-9

In the presence of interleukin-3 and interleukin-5, eosinophil precursors from human umbilical cord blood mononuclear cells were regularly differentiated into mature eosinophil-like cells expressing ... [more ▼]

In the presence of interleukin-3 and interleukin-5, eosinophil precursors from human umbilical cord blood mononuclear cells were regularly differentiated into mature eosinophil-like cells expressing normal morphology and cyanide-resistant peroxidase. O2- production and [Ca2+]i rise were measured in these in vitro differentiated eosinophils after fMLP stimulation; with dihydrorhodamine-123 and fura-2, respectively. Umbilical cord blood-derived eosinophils responded to fMLP (0.01 nM to 3 microM) with a concentration-dependent production of O2- (EC50 = 63.1 +/- 17.2 nM; Emax = 71.0 +/- 6.2 pmol/min/10(6) cells). O2- production was correlated with an fMLP concentration-dependent increase in [Ca2+]i (EC50 = 32.5 +/- 14.9 nM; Emax = 200.0 +/- 23.9 nM). These results indicate that human umbilical cord blood-derived eosinophils demonstrate functional characteristics similar to adult human peripheral blood eosinophils after activation by fMLP. Therefore, the large numbers of eosinophils (2-3 x 10(6)/ml cord blood) which can be obtained by culture of human cord blood mononuclear cells may serve as a useful model for future studies which will provide insight into the pathogenesis of diseases associated with eosinophils. [less ▲]

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See detailSaar-Lor-Lux - Die Bedeutung der lokalen grenzüberschreitenden Kooperation für den europäischen Integrationsprozeß.
Schulz, Christian UL; Brücher, Wolfgang

in Magazin Forschung (1997), (1), 46-53

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See detailMythos Menalk? Neue Fragen zu Pestalozzis Jugend
Tröhler, Daniel UL

in Neue Pestalozzi-Blätter (1997), 3(2), 24-27

Detailed reference viewed: 56 (1 UL)
See detailReview of R.V. Arcilla, For the Love of Perfection.
Biesta, Gert UL

in Interchange (1997), 28(1), 85-88

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See detailLire les "Recherches" de Pestalozzi
Tröhler, Daniel UL

in Bulletin du Centre de Documentation et de Recherche Pestalozzi (1997), (22), 24-28

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See detailPestalozzi - fermerait-il nos écoles?
Tröhler, Daniel UL

in Bulletin du Centre de Documentation et de Recherche Pestalozzi (1997), 22

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See detailStaatliche Lehrerbildung in der Zeit der Helvetik und die Rolle Pestalozzis
Tröhler, Daniel UL

in Beiträge zur Lehrerbildung (1997), 15(3), 293-303

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See detailRevêtements de courbes elliptiques à multiplication complexe par des courbes hyperelliptiques et sommes de caractères
Leprévost, Franck UL; Morain, François

in Journal of Number Theory (1997), 64(2), 165-182

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See detailTrends in service delivery: Psychological practice in rehabilitation settings
Pit-Ten Cate, Ineke UL; Padrone, Frank; Feinblatt, Arlene et al

in Rehabilitation Outllook (1997)

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See detailCustomization of System Software for Large-scale Embedded Applications
Nehmer, Jürgen; Sturm, Peter; Baentsch, Michael et al

in Computer Communications (1997), 20

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See detailCapacity Utilization and Market Power
Fagnart, J.F.; Licandro, O.; Sneessens, Henri UL

in Journal of Economic Dynamics and Control (1997), 22

We propose a theoretical macroeconomic model where capacity underutilization follows from idiosyncratic demand uncertainty at the time monopolistic firms must choose their productive capacity. After their ... [more ▼]

We propose a theoretical macroeconomic model where capacity underutilization follows from idiosyncratic demand uncertainty at the time monopolistic firms must choose their productive capacity. After their investment decision, firms facing a low demand will typically prefer to run excess capacities rather than reduce their profit margin; firms at full capacity will respond to demand fluctuations solely by price adjustments. We show that the proportion of firms with idle capacities influences crucially the short-run response of the economy to exogenous disturbances and, in particular, the relative importance of price and quantity adjustments. [less ▲]

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See detailProcessus de raisonnement et enseignement de l’algèbre au premier degré du secondaire
Vlassis, Joëlle UL; DEMONTY, I

in Informations Pédagogiques (1997), 38

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See detailThe role of actin binding proteins in epithelial morphogenesis: models based upon Listeria movement.
Golsteyn, R. M.; Louvard, D.; Friederich, Evelyne UL

in Biophysical chemistry (1997), 68(1-3), 73-82

We summarize recent findings on the organization of the protein actin in eucaryotic cells. In particular we focus on how actin can be used to generate a vectorial force that is required for cell movement ... [more ▼]

We summarize recent findings on the organization of the protein actin in eucaryotic cells. In particular we focus on how actin can be used to generate a vectorial force that is required for cell movement. These forces arise from protein molecules that recruit actin to the plasma membrane in such a manner that actin filaments extend outward from the cell body. This type of actin dependent force generation has been described in a nucleation-release model, which is one of several models currently being tested to explain actin dependent cell movement. Data in support of this model has arisen unexpectedly from studies of an intracellular bacteria, Listeria monocytogenes. This bacteria uses actin to propel itself during infection of eucaryotic cells. By studying Listeria movement, the roles of several eucaryotic actin interacting proteins have been identified. One of these is zyxin, a human protein that shares important structural and possibly functional properties with ActA, an actin dependent force generating protein of Listeria. We intend to test the function of these and other actin interacting proteins in a simplified system that should facilitate precise measurement of their properties of force generation in vitro. [less ▲]

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See detailPsychophysiological responses to food exposure: an experimental study in binge eaters
Vögele, Claus UL; Florin, Irmela

in International Journal of Eating Disorders (1997), (21), 147-157

Objective: The aim of the present study was to investigate psychophysiological responses to food exposure in binge eaters. Method: Thirty female volunteers reporting regular binge attacks were compared ... [more ▼]

Objective: The aim of the present study was to investigate psychophysiological responses to food exposure in binge eaters. Method: Thirty female volunteers reporting regular binge attacks were compared with 30 nonbinge eaters. Subjects attended individually for the single laboratory session. Continuous measures of heart rate (HR), blood pressure (BP), electroder- mal activity (EDA), and respiration rate were taken during rest and exposure to their favorite binge food. In addition, psychophysiological monitoring continued while subjects were al- lowed to eat after food exposure. Participants also completed inventories assessing restrained eating style (FEV, Revised Restraint Scale). Ratings of nervousness, distress, desire to binge, and hunger were collected repeatedly throughout the experiment. Results: The results indi- cate higher psychophysiological arousal in binge eaters than in nonbinge eaters. Binge eaters maintained a higher arousal level in BP and EDA throughout the food exposure trial than controls. HR during food exposure predicted the relative amount of food consumed during the eating trial across all subjects. This relationship, however, was more pronounced in binge eaters than controls and in restrained compared to unrestrained binge eaters. Discussion: The implications of these results are discussed in terms of conditioning and arousal models of cue reactivity in binge eating. © 1997 by John Wiley & Sons, Inc. Int J Eat Disord 21: 147–157, 1997. [less ▲]

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See detailLes exigences de prix dans les contrats internationaux
Prüm, André UL

in Cahiers de Droit de l'Entreprise (1997), (5),

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See detailDer Grossvater Pestalozzis als pietistisch-pädagogischer Vermittler? Einleitung
Tröhler, Daniel UL

in Neue Pestalozzi-Blätter (1997), 3(1), 28-29

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See detailGeometry-dependent scattering through ballistic microstructures: Semiclassical theory beyond the stationary-phase approximation
Wirtz, Ludger UL; Tang, J. Z.; Burgdorfer, J.

in Physical Review B (1997), 56(12), 7589-7597

The conductance of a ballistic microstructure shows strong fluctuations as a function of the Fermi wave number. We present a semiclassical-theory that describes these fluctuations in terms of bundles of ... [more ▼]

The conductance of a ballistic microstructure shows strong fluctuations as a function of the Fermi wave number. We present a semiclassical-theory that describes these fluctuations in terms of bundles of short trajectories. These trajectories provide the dominant contribution to electron transport through a weakly open microstructure. For the coupling between the quantum wires and the cavity, contributions beyond the stationary phase approximation are taken into account giving rise to diffraction effects. A comparison with full quantum calculations for st rectangular billiard is made. The peak positions of the power spectrum agree very well between the quantum and semiclassical theories. Numerical evidence is found for the breakdown of the semiclassical approximation for long paths. A simple explanation in terms of the dispersion of the semiclassical wave packet in the interior of the cavity is proposed. [less ▲]

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See detailWorld Wide Web caching: the application-level view of the Internet
Baentsch, Michael; Baum, Lothar; Molter, Georg et al

in IEEE Communications Magazine (1997), 35(6), 170-178

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See detailOn the differentiation of heat semigroups and Poisson integrals
Thalmaier, Anton UL

in Stochastics & Stochastics Reports (1997), 61(3-4), 297-321

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See detail0.1 µm T-gate Al-free InP/InGaAs/InP pHEMTs for W-Band Applications Using a Nitrogen Carrier for LP-MOCVD Growth
Schimpf, K.; Sommer, M.; Horstmann, M. et al

in IEEE Electron Device Letters (1997), 18

We report on the dc and RF performance of HEMT’s based on the Al-free material system InP/InGaAs/InP. These structures were grown by LP-MOCVD using a nitrogen carrier. The influence of gate length and ... [more ▼]

We report on the dc and RF performance of HEMT’s based on the Al-free material system InP/InGaAs/InP. These structures were grown by LP-MOCVD using a nitrogen carrier. The influence of gate length and channel composition on the performance of these devices is investigated.We demonstrate that optimum dc and RF performance using highly strained channels can be obtained only if additional composite channels are grown. The cutoff frequencies fT =160 GHz and fmax=260 GHz for a 0.1- um T-gate device indicate the suitability of our devices for W-Band applications. [less ▲]

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See detailTraditionsbewusstsein - eine wenig beachtete Grundhaltung
Tröhler, Daniel UL

in Infos und Akzente (1997), (17), 11-14

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See detailAntagonistic interactions between FGF and BMP signaling pathways: a mechanism for positioning the sites of tooth formation.
Neubuser, A.; Peters, H.; Balling, Rudi UL et al

in Cell (1997), 90(2), 247-55

Vertebrate organogenesis is initiated at sites that are often morphologically indistinguishable from the surrounding region. Here we have identified Pax9 as a marker for prospective tooth mesenchyme prior ... [more ▼]

Vertebrate organogenesis is initiated at sites that are often morphologically indistinguishable from the surrounding region. Here we have identified Pax9 as a marker for prospective tooth mesenchyme prior to the first morphological manifestation of odontogenesis. We provide evidence that the sites of Pax9 expression in the mandibular arch are positioned by the combined activity of two signals, one (FGF8) that induces Pax9 expression and the other (BMP2 and BMP4) that prevents this induction. Thus it appears that the position of the teeth is determined by a combination of two different types of signaling molecules produced in wide but overlapping domains rather than by a single localized inducer. We suggest that a similar mechanism may be used for specifying the sites of development of other organs. [less ▲]

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See detailPedestrian guide to analyzing sequence databases
Rost, B.; Schneider, Reinhard UL; Sander, C.

in WWW-publication (1997)

Over the past few years our means of communication have changed rapidly due to the growth of the World Wide Web (WWW). The Web enables molecular biologists to immediately access databases, scan literature ... [more ▼]

Over the past few years our means of communication have changed rapidly due to the growth of the World Wide Web (WWW). The Web enables molecular biologists to immediately access databases, scan literature, find information about related research and researchers, and to trace cell cultures. Wet-lab biologists can uncover information about the protein of interest without having to become experts in sequence analysis. Here, we present a variety of tools; provide an overview of the state-of-the art in sequence analysis; and described some of the principles of the methods. [less ▲]

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See detailPsychoneuroimmunological correlates of persiting pain in patients who underwent discectomy
Geiss, Andrea; Varadi, E; Steinbach, Klaus et al

in Neuroscience Letters (1997), 237(2), 65-68

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See detailMethodische Bemerkungen zu Kontextualisierung und Wirkungsgeschichte in der pädagogischen Historiographie
Tröhler, Daniel UL

in Neue Pestalozzi-Blätter (1997), 3(2), 28-29

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See detailStructural and functional similarities between the human cytoskeletal protein zyxin and the ActA protein of Listeria monocytogenes.
Golsteyn, R. M.; Beckerle, M. C.; Koay, T. et al

in Journal of cell science (1997), 110 ( Pt 16)

The intracellular bacterial parasite Listeria monocytogenes produces ActA protein at its surface to facilitate the localized assembly of actin-filled comets that are required for movement. The ... [more ▼]

The intracellular bacterial parasite Listeria monocytogenes produces ActA protein at its surface to facilitate the localized assembly of actin-filled comets that are required for movement. The organization of actin in Listeria comets shows striking similarity to the organization of actin at the plasma membrane of mammalian cells. Therefore we examined the possibility that an ActA-like protein is present in mammalian cells. By using antibodies directed against ActA, we identified zyxin as an ActA related protein in a number of cell types. We compared the functions of ActA and zyxin by transient expression of variants tagged with an inner plasma membrane localization sequence (a CAAX box). Targeting of the proline rich domain of zyxin to the plasma membrane disrupts the actin cytoskeleton and cell shape in a manner similar to that which occurs with membrane-targeted ActA sequences. A chimeric protein composed of the N-terminal domain of ActA fused to the N-terminal and central domains of zyxin induced a full ActA response in cells. Furthermore, zyxin and ActA exhibit common protein partners in vitro. On the basis of the shared properties of zyxin and ActA, we propose that zyxin enhances actin organizing activity in mammalian cells. [less ▲]

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See detailSequence analysis of the Methanococcus jannaschii genome and the prediction of protein function
Andrade, M.; Casari, G.; deDaruvar, A. et al

in Computer Applications in the Biosciences [=CABIOS] (1997), 13(4), 481-483

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See detailEffects of moexiprilat on oestrogen-stimulated cardiac fibroblast growth.
Grohe, C.; Kahlert, S.; Lobbert, K. et al

in British journal of pharmacology (1997), 121(7), 1350-4

1. The effects of 2-2-(1-(ethoxycarbonyl)-3-phenylpropyl)-[amino-oxopropyl]-6,7-dimethoxy- 1,2,3,4-tetrahydroisoquinoline-3 carboxylic acid (moexiprilat), 17beta-oestradiol (E2), oestrone (ES) and ... [more ▼]

1. The effects of 2-2-(1-(ethoxycarbonyl)-3-phenylpropyl)-[amino-oxopropyl]-6,7-dimethoxy- 1,2,3,4-tetrahydroisoquinoline-3 carboxylic acid (moexiprilat), 17beta-oestradiol (E2), oestrone (ES) and angiotensin II (AII) on growth and activation of oestrogen receptors and the immediate-early gene egr-1 were investigated in neonatal rat cardiac fibroblasts of female and male origin. 2. In BrdU proliferation assays, oestrone (10(-7)- 10(-9) M) stimulated cardiac fibroblast growth in a concentration-dependent fashion (maximum at 10(-7) M, 4.0 fold +/- 0.14 in female and 3.1 fold +/- 0.06 in male cells, n=9, P<0.05), while E2 (10(-7)-10(-9) M) had no effect. Moexiprilat (10(-7)M) completely inhibited oestrone-induced cardiac fibroblast growth. 3. Angiotensin II (10(-7) M) induced cardiac fibroblast growth (female 4.1 fold +/- 0.1/male 3.9 fold +/- 0.2; n=9, P<0.05). Angiotensin II induced oestrogen receptor (maximum 21.8 fold at 60 min) and egr-1 (maximum 47.5 fold at 60 min) expression in a time-dependent fashion. 4. In immunoblot experiments, oestrogen activated oestrogen receptor (ES: 12.8 fold +/- 2.0; E2: 14.7 fold +/- 4.9; n=3, P<0.05) and egr-1 (ES: 5.1 fold, +/- 0.24; E2: 3.8 fold, +/- 0.25; n=3, P<0.05) expression. The induction of oestrogen receptor and egr-1 protein expression was time-dependent and inhibited by moexiprilat. 5. Our results show that oestrone and 17beta-oestradiol reveal a significant difference in their potential to activate cardiac fibroblast growth in female and male cells and that oestrone-stimulated growth is inhibited by moexiprilat. The inhibition of oestrone-stimulated cardiac fibroblast growth by moexiprilat may contribute to the beneficial effects seen in postmenopausal women with hypertensive heart disease treated with ACE inhibitors. [less ▲]

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See detailSegment-specific expression of the gap junction gene connexin 31 during hindbrain development
Dahl, E; Willecke, K; Balling, Rudi UL

in Development Genes & Evolution (1997), (207), 359-361

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See detailThe nature of the starter unit for the rapamycin polyketide synthase
König, Ariane UL; Schwecke, T.; Molnár, I. et al

in Angewandte Chemie International Edition (1996), 35(19), 2249-2251

A remarkably high level of incorporation is observed when 2,2,5,5-tetradeutero -3,4- dihydroxycyclo -hexanecarboxylic acid is fed to the rapamycin-producing organism. Intriguingly, however, analysis of ... [more ▼]

A remarkably high level of incorporation is observed when 2,2,5,5-tetradeutero -3,4- dihydroxycyclo -hexanecarboxylic acid is fed to the rapamycin-producing organism. Intriguingly, however, analysis of the gene sequence for the rapamycin polyketide synthase has suggested that the free acid may not normally be involved in rapamycin biosynthesis. [less ▲]

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See detailOrganisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of the enzymatic domains in the modular polyketide synthase
Aparicio, J. F.; Molnar, I.; Schwecke, T. et al

in Gene (1996), 169(1), 9-16

The three giant multifunctional polypeptides of the rapamycin (Rp)-producing polyketide synthase (RAPS1, RAPS2 and RAPS3) have recently been shown to contain 14 separate sets, or modules, of enzyme ... [more ▼]

The three giant multifunctional polypeptides of the rapamycin (Rp)-producing polyketide synthase (RAPS1, RAPS2 and RAPS3) have recently been shown to contain 14 separate sets, or modules, of enzyme activities, each module catalysing a specific round of polyketide chain extension. Detailed sequence comparison between these protein modules has allowed further characterisation of aa that may be important in catalysis or specificity. The acyl-carrier protein (ACP), beta-ketoacyl-ACP synthase (KS) and acyltransferase (AT) domains (the core domains) have an extremely high degree of mutual sequence homology. The KS domains in particular are almost perfect repeats over their entire length. Module 14 shows the least homology and is unique in possessing only core domains. The enoyl reductase (ER), beta-ketoacyl-ACP reductase (KR) and dehydratase (DH) domains are present even in certain modules where they are not apparently required. Four DH domains can be recognised as inactive by characteristic deletions in active site sequences, but for two others, and for KR and ER in module 3, the sequence is not distinguishable from that of active counterparts in other modules. The N terminus of RAPS1 contains a novel coenzyme A ligase (CL) domain that activates and attaches the shikimate-derived starter unit, and an ER activity that may modify the starter unit after attachment. The sequence comparison has revealed the surprisingly high sequence similarity between inter-domain 'linker' regions, and also a potential amphipathic helix at the N terminus of each multienzyme subunit which may promote dimerisation into active species. [less ▲]

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See detailOrganisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of the genes flanking the polyketide synthase
Aparicio, J. F.; Molnár, I.; Schwecke, T. et al

in Gene (1996), 169(1), 1-7

The three giant multifunctional polypeptides of the rapamycin (Rp)-producing polyketide synthase (RAPS1, RAPS2 and RAPS3) have recently been shown to contain 14 separate sets, or modules, of enzyme ... [more ▼]

The three giant multifunctional polypeptides of the rapamycin (Rp)-producing polyketide synthase (RAPS1, RAPS2 and RAPS3) have recently been shown to contain 14 separate sets, or modules, of enzyme activities, each module catalysing a specific round of polyketide chain extension. Detailed sequence comparison between these protein modules has allowed further characterisation of aa that may be important in catalysis or specificity. The acyl-carrier protein (ACP), beta-ketoacyl-ACP synthase (KS) and acyltransferase (AT) domains (the core domains) have an extremely high degree of mutual sequence homology. The KS domains in particular are almost perfect repeats over their entire length. Module 14 shows the least homology and is unique in possessing only core domains. The enoyl reductase (ER), beta-ketoacyl-ACP reductase (KR) and dehydratase (DH) domains are present even in certain modules where they are not apparently required. Four DH domains can be recognised as inactive by characteristic deletions in active site sequences, but for two others, and for KR and ER in module 3, the sequence is not distinguishable from that of active counterparts in other modules. The N terminus of RAPS1 contains a novel coenzyme A ligase (CL) domain that activates and attaches the shikimate-derived starter unit, and an ER activity that may modify the starter unit after attachment. The sequence comparison has revealed the surprisingly high sequence similarity between inter-domain 'linker' regions, and also a potential amphipathic helix at the N terminus of each multienzyme subunit which may promote dimerisation into active species. [less ▲]

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See detailSur une conjecture sur les points de torsion rationnels des Jacobiennes de courbes
Leprévost, Franck UL

in Journal für die Reine und Angewandte Mathematik (1996), 473

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See detailDagmar Schifferli: Anna Pestalozzi-Schulthess. Ihr Leben mit Heinrich Pestalozzi.
Tröhler, Daniel UL

in Bulletin der Schweizerischen Gesellschaft für die Erforschung des 18. Jahrhunderts (1996), 9

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See detailPAX genes and human neural tube defects: an amino acid substitution in PAX1 in a patient with spina bifida.
Hol, F. A.; Geurds, M. P.; Chatkupt, S. et al

in Journal of Medical Genetics (1996), 33(8), 655-60

From studies in the mouse and from the clinical and molecular analysis of patients with type 1 Waardenburg syndrome, particular members of the PAX gene family are suspected factors in the aetiology of ... [more ▼]

From studies in the mouse and from the clinical and molecular analysis of patients with type 1 Waardenburg syndrome, particular members of the PAX gene family are suspected factors in the aetiology of human neural tube defects (NTD). To investigate the role of PAX1, PAX3, PAX7, and PAX9, allelic association studies were performed in 79 sporadic and 38 familial NTD patients from the Dutch population. Sequence variation was studied by SSC analysis of the paired domain regions of the PAX1, PAX7, and PAX9 genes and of the complete PAX3 gene. In one patient with spina bifida, a mutation in the PAX1 gene was detected changing the conserved amino acid Gln to His at position 42 in the paired domain of the protein. The mutation was inherited through the maternal line from the unaffected grandmother and was not detected in 300 controls. In the PAX3 gene, variation was detected at several sites including a Thr/Lys amino acid substitution in exon 6. All alleles were present among patients and controls in about the same frequencies. However, an increased frequency of the rare allele of a silent polymorphism in exon 2 was found in NTD patients, but no significant association was observed (p = 0.06). No sequence variation was observed in the paired domain of the PAX7 and PAX9 genes. Our findings so far do not support a major role of the PAX genes examined in the aetiology of NTD. However, the detection of a mutation in PAX1 suggests that, in principle, this gene can act as a risk factor for human NTD. [less ▲]

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See detailJugend und Politik
Willems, Helmut UL; Gille, Martina

in Jugendhilfe Report (1996), (2), 35-35

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See detailDer Reminiszenzfragebogen: Skalenkonstruktion und teststatistische Überprüfung.
Mayer, Anne-Kathrin; Filipp, Sigrun-Heide; Ferring, Dieter UL

in Focus Diagnostica (1996), 42(2)

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See detailEndothelin-1 does not modulate O2.release and [Ca(2+)]i variations in resting or differentiated HL-60 cells
Gallois, A.; Bueb, Jean-Luc UL; Tschirhart, Eric UL

in Fundamental and Clinical Pharmacology (1996), 10(1), 28-32

Endothelin-1 (ET-1) by itself was not an effective stimulus for inducing superoxide (O2.) generation in human resting or DMSO-differentiated neutrophil-like HL-60 cells. ET-1 (0.01-100 nM) was not able to ... [more ▼]

Endothelin-1 (ET-1) by itself was not an effective stimulus for inducing superoxide (O2.) generation in human resting or DMSO-differentiated neutrophil-like HL-60 cells. ET-1 (0.01-100 nM) was not able to modulate O2. generation stimulated by the chemotactic peptide N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP, EC50 = 4.24 +/- 1.63 nM in the absence and 3.16 +/- 1.95 nM in the presence of ET-1). Neither did ET-1 (0.01-100 nM) promote the mobilization of intracellular calcium ions or modulate fMLP-induced [Ca(2+)]i increase in this model of human neutrophils. Phosphoramidon, a neutral endopeptidase inhibitor, was not able to reveal any biological (O2.) or biochemical ([Ca(2+)]i response to ET-1 in the absence or in the presence of fMLP in these cells. These results indicate that DMSO-differentiated neutrophil-like HL-60 cells are not sensitive to ET-1 in terms of O2. generation or [Ca(2+)]i variations. [less ▲]

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