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See detailAsymptotic Eigenvalue Distributions and Capacity for MIMO Channels under Correlated Fading
Martin, Cristoff; Ottersten, Björn UL

in IEEE Transactions on Wireless Communications (2004), 3(4), 13501359

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See detailLanguage planning in the Pacific: Endangered English-based creoloids on Norfolk and Palmerston Islands
Ehrhart, Sabine UL; Mair, Christian; Mühlhäusler, Peter

in Alauda (2004), 614

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See detailA fluorescence cell biology approach to map the second integrin-binding site of talin to a 130-amino acid sequence within the rod domain
Tremuth, Laurent A; Kreis, Stephanie UL; Melchior, Chantal et al

in Journal of Biological Chemistry (2004), 279(21), 22258-22266

The cytoskeletal protein talin, which provides a direct link between integrins and actin filaments, has been shown to contain two distinct binding sites for integrin β subunits. Here, we report the ... [more ▼]

The cytoskeletal protein talin, which provides a direct link between integrins and actin filaments, has been shown to contain two distinct binding sites for integrin β subunits. Here, we report the precise delimitation and a first functional analysis of the talin rod domain integrin-binding site. Partially overlapping cDNAs covering the entire human talin gene were transiently expressed as DsRed fusion proteins in Chinese hamster ovary cells expressing α IIbβ 3, linked to green fluorescent protein (GFP). Two-color fluorescence analysis of the transfected cells, spread on fibrinogen, revealed distinct subcellular staining patterns including focal adhesion, actin filament, and granular labeling for different talin fragments. The rod domain fragment G (residues 1984-2344), devoid of any known actin- or vinculin-binding sites, colocalized with β 3-GFP in focal adhesions. Direct in vitro interaction of fragment G with native platelet integrin α IIbβ 3 or with the recombinant wild type, but not the Y747A mutant β 3 cytoplasmic tail, linked to glutathione S-transferase, was demonstrated by surface plasmon resonance analysis and pull-down assays, respectively. Here, we demonstrate for the first time the in vivo relevance of this interaction by fluorescence resonance energy transfer between β 3-GFP and DsRed-talin fragment G. Further in vitro pull-down studies allowed us to map out the integrin-binding site within fragment G to a stretch of 130 residues (fragment J, residues 1984-2113) that also localized to focal adhesions. Finally, we show by a cell biology approach that this integrin- binding site within the talin rod domain is important for β 3-cytoskeletal interactions but does not participate in α IIbβ 3 activation. [less ▲]

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See detailCellular structures in solid fuel combustions.
Peters, Bernhard UL

in Flow, Turbulence and Combustion (2004), 73(3-4)

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See detailLebensstil und Leselust. Literarische Enkulturation und Soziale Milieus
Mein, Georg UL

in Literatur im Unterricht : Texte der Gegenwartsliteratur für die Schule (2004), (3), 247-262

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See detailThe French and the Dutch East india companies in comparative legal perspective
Conac, Pierre-Henri UL

in ouvrage collectif publié aux Pays-Bas, sous le patronage des Universités de Groningen, Leiden et Nimègue, à l’occasion du 400ème anniversaire de la Compagnie hollandaise des Indes orientales (2004)

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See detailParis, 29 avril 2003
Cuniberti, Gilles UL; Kaplan, Charles

in Juris-Classeur périodique (2004)

Nature des ordonnances de référé pré-arbitral de la CCI.

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See detailA psychobiological perspective on genetic determinants of hypothalamus-pituitary-adrenal axis activity
Wüst, S.; Federenko, I. S.; Van Rossum, E. F. C. et al

in Annals of the New York Academy of Sciences (2004), 1032

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See detailPlasma membrane Ca2+ ATPase 4 is required for sperm motility and male fertility.
Schuh, Kai; Cartwright, Elizabeth J.; Jankevics, Eriks et al

in The Journal of biological chemistry (2004), 279(27), 28220-6

Calcium and Ca(2+)-dependent signals play a crucial role in sperm motility and mammalian fertilization, but the molecules and mechanisms underlying these Ca(2+)-dependent pathways are incompletely ... [more ▼]

Calcium and Ca(2+)-dependent signals play a crucial role in sperm motility and mammalian fertilization, but the molecules and mechanisms underlying these Ca(2+)-dependent pathways are incompletely understood. Here we show that homozygous male mice with a targeted gene deletion of isoform 4 of the plasma membrane calcium/calmodulin-dependent calcium ATPase (PMCA), which is highly enriched in the sperm tail, are infertile due to severely impaired sperm motility. Furthermore, the PMCA inhibitor 5-(and-6)-carboxyeosin diacetate succinimidyl ester reduced sperm motility in wild-type animals, thus mimicking the effects of PMCA4 deficiency on sperm motility and supporting the hypothesis of a pivotal role of the PMCA4 on the regulation of sperm function and intracellular Ca(2+) levels. [less ▲]

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See detailThe Establishment of the Standard History of Philosophy of Education and forgotten Traditions of Education
Tröhler, Daniel UL

in Studies in Philosophy and Education (2004), 23(5/6), 367-391

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See detailModeling and experimental validation of the signal transduction via the Escherichia coli sucrose phospho transferase system.
Sauter, Thomas UL; Gilles, E. D.

in Journal of Biotechnology (2004), 110(2), 181-99

Bacterial signal processing was investigated concerning the sucrose phosphotransferase system (sucrose PTS) in the bacterium Escherichia coli as an example. The about 20 different phosphotransferase ... [more ▼]

Bacterial signal processing was investigated concerning the sucrose phosphotransferase system (sucrose PTS) in the bacterium Escherichia coli as an example. The about 20 different phosphotransferase systems (PTSs) of the cell fulfill besides the transport of various carbohydrates, also the function of one signal processing system. Extra- and intracellular signals are converted within the PTS protein chain to important regulatory signals affecting, e.g. carbon metabolism and chemotaxis. A detailed dynamical model of the sucrose PTS was developed describing transport and signal processing function. It was formulated using a detailed description of complex formation and phosphate transfer between the chain proteins. Model parameters were taken from literature or were identified with own experiments. Simulation studies together with experimental hints showed that the dynamic behavior of phosphate transfer in the PTS runs within 1 s. Therefore a description of steady state characteristics is sufficient for describing the signaling properties of the sucrose PTS. A steady state characteristic field describes the degree of phosphorylation of the PTS protein EIIACrr as a function of the input variables extracellular sucrose concentration and intracellular phosphoenolpyruvate (PEP):pyruvate ratio. The model has been validated with different experiments performed in a CSTR using a sucrose positive E. coli W3110 derivative. A method for determining intracellular metabolite concentrations has been developed. A sample preparation technique using a boiling ethanol buffer solution was successfully applied. The PTS output signal degree of phosphorylation of EIIACrr was also measured. Steady state conditions with varying dilution rate and dissolved oxygen concentration and dynamical variations applying different stimuli to the culture were considered. Pulse, and stop feeding experiments with limiting sucrose concentrations were performed. Simulation and experimental results matched well. The same holds for the expanded sucrose PTS and glycolysis model. [less ▲]

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See detailAction déclaratoire et droit judiciaire européen
Cuniberti, Gilles UL

in Journal du Droit International (2004)

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See detailDécision de la Cour de cassation, 1ère Civ., 30 juin 2004
Cuniberti, Gilles UL

in Droit et Procédures (2004)

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See detailVerarbeitung von personbeschreibender Information als Textverstehen
Krolak-Schwerdt, Sabine UL; Wintermantel, Margret

in Psychologische Rundschau: Ueberblick Uber die Fortschritte der Psychologie in Deutschland, Oesterreich, und der Schweiz (2004), 55(1), 11-18

In this paper, relations between text comprehension and social cognition are discussed. It is argued that theories and research methods from the domain of text comprehension are well suited to highlight ... [more ▼]

In this paper, relations between text comprehension and social cognition are discussed. It is argued that theories and research methods from the domain of text comprehension are well suited to highlight the processing of person information. In research on person memory and impression formation stimulus materials are used which typically consist of a listwise presentation of traits and/or behavior describing statements. In contrast, research on text comprehension yields evidence that a crucial component of successful comprehension is provided by relations between the statements. These induce a coherent and hierarchically organized structure rather than an unorganized list. It is argued that analyzing impression formation and social judgment from text descriptions of persons provides a superior approach to social cognition by representing the complexity of relations between person attributes and their cognitive representations more adequately. [less ▲]

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See detailDer Computer – "Nur" Werkzeug oder den Unterricht veränderndes Medium?
Sunnen, Patrick UL

in Online-Zeitschrift Grundschulforschung (2004), (8),

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See detailDesign of channel estimate dependent space-time block codes
Jöngren, George; Skoglund, Mikael; Ottersten, Björn UL

in IEEE Transactions on Communications (2004), 52(7), 11911203

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See detailGlobal analysis of piecewise linear systems using impact maps and quadratic surface Lyapunov functions
Goncalves, Jorge UL; Megretski, A.; Dahleh, M.

in IEEE Transactions on Automatic Control (2003), 48(12), 2089-2106

This paper presents an entirely new constructive global analysis methodology for a class of hybrid systems known as piecewise linear systems (PLS). This methodology infers global properties of PLS solely ... [more ▼]

This paper presents an entirely new constructive global analysis methodology for a class of hybrid systems known as piecewise linear systems (PLS). This methodology infers global properties of PLS solely by studying the behavior at switching surfaces associated with PLS. The main idea is to analyze impact maps, i.e., maps from one switching surface to the next switching surface. Such maps are known to be “unfriendly” maps in the sense that they are highly nonlinear, multivalued, and not continuous. We found, however, that an impact map induced by an linear time-invariant flow between two switching surfaces can be represented as a linear transformation analytically parametrized by a scalar function of the state. This representation of impact maps allows the search for surface Lyapunov functions (SuLF) to be done by simply solving a semidefinite program, allowing global asymptotic stability, robustness, and performance of limit cycles and equilibrium points of PLS to be efficiently checked. This new analysis methodology has been applied to relay feedback, on/off and saturation systems, where it has shown to be very successful in globally analyzing a large number of examples. In fact, it is still an open problem whether there exists an example with a globally stable limit cycle or equilibrium point that cannot be successfully analyzed with this new methodology. Examples analyzed include systems of relative degree larger than one and of high dimension, for which no other analysis methodology could be applied. This success in globally analyzing certain classes of PLS has shown the power of this new methodology, and suggests its potential toward the analysis of larger and more complex PLS. [less ▲]

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See detailEl aprendizaje y la ensenanza de los movimientos: Contradicciones entre la teoría y la práctica del deporte?
Bund, Andreas UL; Hopf, Herbert

in Educación física Chile (2003), 262

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See detailA framework for designing transgenic crops - science, safety, and citizen’s concerns.
König, Ariane UL

in Nature Biotechnology (2003), 21(11), 1274-1279

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See detailRapid stimulation of free glucuronate formation by non-glucuronidable xenobiotics in isolated rat hepatocytes
Linster, Carole UL; Van Schaftingen, Emile

in Journal of Biological Chemistry (2003), 278(38), 36328-33

Vitamin C synthesis in rat liver is enhanced by several xenobiotics, including aminopyrine and chloretone. The effect of these agents has been linked to induction of enzymes potentially involved in the ... [more ▼]

Vitamin C synthesis in rat liver is enhanced by several xenobiotics, including aminopyrine and chloretone. The effect of these agents has been linked to induction of enzymes potentially involved in the formation of glucuronate, a precursor of vitamin C. Using isolated rat hepatocytes as a model, we show that a series of agents (aminopyrine, antipyrine, chloretone, clotrimazole, metyrapone, proadifen, and barbital) induced in a few minutes an up to 15-fold increase in the formation of glucuronate, which was best observed in the presence of sorbinil, an inhibitor of glucuronate reductase. They also caused an approximately 2-fold decrease in the concentration of UDP-glucuronate but little if any change in the concentration of UDP-glucose. Depletion of UDP-glucuronate with resorcinol or d-galactosamine markedly decreased the formation of glucuronate both in the presence and in the absence of aminopyrine, confirming the precursor-product relationship between UDP-glucuronate and free glucuronate. Most of the agents did not induce the formation of detectable amounts of glucuronides, indicating that the formation of glucuronate is not due to a glucuronidation-deglucuronidation cycle. With the exception of barbital (which inhibits glucuronate reductase), all of the above mentioned agents also caused an increase in the concentration of ascorbic acid. They had little effect on glutathione concentration, and their effect on glucuronate and vitamin C formation was not mimicked by glutathione-depleting agents such as diamide and buthionine sulfoximine. It is concluded that the stimulation of vitamin C synthesis exerted by some xenobiotics is mediated through a rapid increase in the conversion of UDP-glucuronate to glucuronate, which does not apparently involve a glucuronidation-deglucuronidation cycle. [less ▲]

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See detail"Kinder stark machen!" Selbstvertrauen fördern
Bund, Andreas UL; Biemann, Anja; Sudermann, Arthur

in Sportpraxis (2003), 44(4), 20-24

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See detailThe functionally defined right occipital and fusiform "face areas" discriminate novel from visually familiar faces
Rossion, Bruno; Schiltz, Christine UL; Crommelinck, Marc

in NeuroImage (2003), 19(3), 877-883

Neuroimaging (PET and fMRI) studies have identified a set of brain areas responding more to faces than to other object categories in the visual extrastriate cortex of humans. This network includes the ... [more ▼]

Neuroimaging (PET and fMRI) studies have identified a set of brain areas responding more to faces than to other object categories in the visual extrastriate cortex of humans. This network includes the middle lateral fusiform gyrus (the fusiform face area, or FFA) as well as the inferior occipital gyrus (occipital face area, OFA). The exact functions of these areas in face processing remain unclear although it has been argued that their primary function is to distinguish faces from nonface object categories-"face detection"-or also to discriminate among faces, irrespective of their visual familiarity to the observer. Here, we combined the data from two previous positron emission tomography (PET) studies to show that the functionally defined face areas are involved in the automatic discrimination between unfamiliar faces and familiar faces. Consistent with previous studies, a face localizer contrast (faces-objects) revealed bilateral activation in the middle lateral fusiform gyrus (FFA, BA37) and in the right inferior occipital cortex (OFA, BA19). Within all the regions of the right hemisphere, larger levels of activation were found for unfamiliar as compared to familiar faces. These results suggest that the very same areas involved in categorizing faces at the basic or individual level, play a role in differentiating familiar faces from new faces, showing an overlap between visual and presemantic mnesic representations of faces in the right hemisphere. [less ▲]

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See detailCompetitiveness and Employment in a Small Open Economy
Bourgain, Arnaud UL; Pieretti, Patrice UL

in Journal of Economic Integration (2003), 18(2), 391-405

The model developed in this article leads to a reduced form that synthesizes the relevant determinants of job creation in a small open economy. Among these factors, we stress the role of competitiveness ... [more ▼]

The model developed in this article leads to a reduced form that synthesizes the relevant determinants of job creation in a small open economy. Among these factors, we stress the role of competitiveness that is measured by an indicator taking into account the foreign price sensitiveness of domestic exporters. Our model shows that the stronger the price setting power of domestic firms, the greater the impact of competitiveness on employment is. The model is used to empirically estimate the determinants of job creation over the period 1970-1998, in Luxembourg, a small economy, where employment expanded dramatically during the last decades. [less ▲]

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See detailBewegungslernen und -lehren in der Praxis - Widersprüche in der Forschung?
Bund, Andreas UL

in Betrifft Sport (2003), 25

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See detailSelbstbestimmtes Lernen im Sportunterricht: Interviews mit Sportlehrerinnen und Sportlehrern
Bund, Andreas UL; Angert, Regine; Wiemeyer, Josef

in Sportunterricht (2003), 52(3), 74-79

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See detailStrategien beim selbstgesteuerten Bewegungslernen
Bund, Andreas UL

in dvs-Informationen (2003), 18

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See detailActivation of STAT3 by IL-6 and IL-10 in primary human macrophages is differentially modulated by suppressor of cytokine signaling 3.
Niemand, Claudia; Nimmesgern, Ariane; Haan, Serge UL et al

in Journal of immunology (2003), 170(6), 3263-72

On human macrophages IL-10 acts as a more potent anti-inflammatory cytokine than IL-6, although both cytokines signal mainly via activation of the transcription factor STAT3. In this study we compare IL ... [more ▼]

On human macrophages IL-10 acts as a more potent anti-inflammatory cytokine than IL-6, although both cytokines signal mainly via activation of the transcription factor STAT3. In this study we compare IL-10 and IL-6 signaling in primary human macrophages derived from blood monocytes. Pretreatment of macrophages with PMA or the proinflammatory mediators LPS and TNF-alpha blocks IL-6-induced STAT3 activation, whereas IL-10-induced activation of STAT3 remains largely unaffected. Although LPS induces the feedback inhibitor suppressor of cytokine signaling 3 (SOCS3) in macrophages, inhibition of IL-6 signal transduction by LPS occurs rapidly and does not depend on gene transcription. We also found that pretreatment of macrophages with IL-10 inhibits subsequent STAT3 activation by IL-6, whereas IL-10-induced STAT3 activation is not affected by preincubation with IL-6. This cross-inhibition is dependent on active transcription and might therefore be explained by different sensitivities of IL-10 and IL-6 signaling toward the feedback inhibitor SOCS3, which is induced by both cytokines. In contrast to the IL-6 signal transducer gp130, which has been previously shown to recruit SOCS3 to one of its phosphotyrosine residues (Y759), peptide precipitation experiments suggest that SOCS3 does not interact with phosphorylated tyrosine motifs of the IL-10R. Taken together, different sensitivities of IL-10 and IL-6 signaling toward mechanisms that inhibit the Janus kinase/STAT pathway define an important mechanism that contributes to the different anti-inflammatory potencies of these two cytokines. [less ▲]

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See detailGrundschulkinder in Harmonie bringen: Eine Kultur des Bewegens
Andersen, Katja Natalie UL

in Grundschulmagazin (2003), 71(3/4), 29-32

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See detailProcessus intra-familiaux et engagement parental : un modèle de compréhension du parcours scolaire
Poncelet, Débora UL

in Scientia Paedagogica Experimentalis (2003), 40(2), 201-222

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See detailLa C.O.B. et le C.M.F. protègent les analystes financiers de l'influence du droit américain
Conac, Pierre-Henri UL

in Petites Affiches, la Loi (2003), 3(154), 3-3

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See detailDrying and prolysis of wood particles: experiments and simulation.
Peters, Bernhard UL; Bruch, Christian

in Journal of Analytical and Applied Pyrolysis (2003), 70

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See detailL’incidence du lieu d’exécution du contrat sur la loi applicable
Cuniberti, Gilles UL

in La Semaine Juridique Edition Générale (2003)

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See detailAgenten des Wandels: Wissensintensive Dienstleister und betrieblicher Umweltschutz.
Schulz, Christian UL; Soyez, Dietrich UL

in Zeitschrift für Wirtschaftsgeographie (2003), 47

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See detailA Bismut type formula for the Hessian of heat semigroups
Arnaudon, Marc; Plank, Holger; Thalmaier, Anton UL

in Comptes Rendus. Mathématique (2003), 336(8), 661-666

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See detailBook Review: John Rodden: Repainting the Little Red schoolhouse: a history of eastern German education 1945-1995
Karl, Ute UL

in Educational Review (2003), 55(3), 347-347

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See detailGrundfälle zum Europarecht - 7. Teil (Das gemeinschaftsrechtliche Wettbewerbsrecht)
Cole, Mark UL; Haus, Florian C.

in Juristische Schulung : Zeitschrift für Studium und Referendariat (2003)

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See detailYang-Mills fields and random holonomy along Brownian bridges
Arnaudon, Marc; Thalmaier, Anton UL

in Annals of Probability (2003), 31(2), 769-790

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See detailEfficient Greedy Learning of Gaussian Mixture Models
Verbeek, J. J.; Vlassis, Nikos UL; Kröse, B.

in Neural Computation (2003), 15(2), 469-485

This article concerns the greedy learning of gaussian mixtures. In the greedy approach, mixture components are inserted into the mixture one aftertheother.We propose a heuristic for searching for the ... [more ▼]

This article concerns the greedy learning of gaussian mixtures. In the greedy approach, mixture components are inserted into the mixture one aftertheother.We propose a heuristic for searching for the optimal component to insert. In a randomized manner, a set of candidate new components is generated. For each of these candidates, we find the locally optimal new component and insert it into the existing mixture. The resulting algorithm resolves the sensitivity to initialization of state-of-the-art methods, like expectation maximization, and has running time linear in the number of data points and quadratic in the (final) number of mixture components. Due to its greedy nature, the algorithm can be particularly useful when the optimal number of mixture components is unknown. Experimental results comparing the proposed algorithm to other methods on density estimation and texture segmentation are provided. [less ▲]

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See detailThe price-volatility feedback rate: an implementable mathematical indicator of market stability
Barucci, Emilio; Malliavin, Paul; Mancino, Maria Elvira et al

in Math. Finance (2003), 13(1), 17-35

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See detailLe système scolaire luxembourgeois: Un système scolaire scolaire peu efficace malgré ou à cause de son caractère multilingue?
Portante, Dominique UL; Martin, Romain UL

in Cahiers du Service de Pédagogie Expérimentale (SPE) (2003), 15/16(4), 516-532

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See detailEffets des préretraites sur l'emploi
Sneessens, Henri UL; Pierrard, Olivier; Shadman, Fatemeh

in Revue Française d'Economie (2003), 18(1), 133-155

The paper analyzes the mechanisms by which policies aiming at downsizing the labour force (like early retirement policies) may in fact lead to lower employment levels, even though the equilibrium ... [more ▼]

The paper analyzes the mechanisms by which policies aiming at downsizing the labour force (like early retirement policies) may in fact lead to lower employment levels, even though the equilibrium unemployment rate is decreased. Numerical examples suggest that job losses may be potentially important, even in the case where early retirements are concentrated among groups with high unemployment levels (low-skilled workers). The model takes into account the effects coming from imperfect competition and wage negotiations, as well as those coming from frictions and matching difficulties in an economy with continuous job creations and destructions. Reducing the labour force by promoting early retirement induces in the long run an increase in labour costs, either directly through the effect of unemployment on wages, or indirectly via the effect of unemployment on hiring difficulties. [less ▲]

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See detailVertical crustal motion observed in the BIFROST project
Scherneck, Hans-Georg; Johansson, Jan M.; Koivula, Hannu et al

in Journal of Geodynamics (2003), 35(4-5), 425-441

This paper reports from investigations on the robustness of estimated rates of intraplate motion from the continuous GPS project BIFROST (Baseline Inferences from Fennoscandian Rebound Observations ... [more ▼]

This paper reports from investigations on the robustness of estimated rates of intraplate motion from the continuous GPS project BIFROST (Baseline Inferences from Fennoscandian Rebound Observations, Sealevel and Tectonics). We study loading effects due to ocean, atmosphere and hydrology and their impact on estimated rate parameters. We regularly find the admittance of a modelled perturbation at less than fifty percent of the full effect. We think that the finding relates to a difficult noise situation at all periods, and that a satisfying model for the dominating noise source has not been found yet. An additional reason for low admittance is found in the mapping process of the no-fiducial network solution into a conventional reference frame. [less ▲]

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See detailA fusion protein of the gp130 and interleukin-6Ralpha ligand-binding domains acts as a potent interleukin-6 inhibitor.
Ancey, Cecile; Kuster, Andrea; Haan, Serge UL et al

in Journal of Biological Chemistry (2003), 278(19), 16968-72

Interleukin (IL)-6 is involved in the maintenance and progression of several diseases such as multiple myeloma, rheumatoid arthritis, or osteoporosis. The present work aims at the development of an IL-6 ... [more ▼]

Interleukin (IL)-6 is involved in the maintenance and progression of several diseases such as multiple myeloma, rheumatoid arthritis, or osteoporosis. The present work aims at the development of an IL-6 inhibitor for the use in anti-cytokine therapies. The IL-6 receptor is composed of two different subunits, an alpha-subunit (IL-6Ralpha) that binds IL-6 with low affinity and a beta-subunit (gp130) that binds the IL-6.IL-6Ralpha complex with high affinity and as a result triggers intracellular signaling. In its soluble form, gp130 is a natural antagonist that neutralizes IL-6.soluble IL-6Ralpha complexes. It was our strategy to appropriately fuse the two receptor subunit fragments involved in IL-6 receptor complex formation to bind IL-6 with high affinity and to antagonize its effects. The ligand-binding domains of gp130 (D1-D2-D3) and IL-6Ralpha (D2-D3) were connected using three different linkers. The resulting constructs were expressed in stably transfected insect cells and tested for their ability to inhibit IL-6 activity in several in vitro systems. All fusion proteins were strong inhibitors of IL-6 signaling and abrogated IL-6-induced phosphorylation of STAT3, proliferation of transfected Ba/F3 cells, and induction of acute-phase protein synthesis. As intended, the fused receptors were much more effective than the separately expressed soluble receptor proteins. The fusion protein strategy presented here can also be applied to other cytokines that signal via receptors composed of two different subunits to design new potent inhibitors for anti-cytokine therapies. [less ▲]

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See detailCity vs. Bits. Von der Beschleunigung der Nachrichten und der Trägheit des Raumes.
Hesse, Markus UL

in Kommune: Forum für Politik, Ökonomie, Kultur (2003), 21(5), 99-104

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See detailTesting Condtional Moment Restrictions
Tripathi, Gautam UL; Kitamura, Yuichi

in Annals of Statistics (2003), 31

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See detailBildung - Kanon - Bildungskanon?
Mein, Georg UL

in Mitteilungen des Deutschen Germanistenverbandes (2003), (4), 534-550

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See detailBeta3 integrins: major therapeutic targets of the near future.
Schaffner-Reckinger, Elisabeth UL

in Bulletin de la Société des Sciences Médicales du Grand-Duché de Luxembourg (2003), (1), 23-34

Integrins are major cell adhesion receptors which assume two important functions: first they act as anchoring molecules allowing firm cellular attachment to the extracellular matrix, and second they work ... [more ▼]

Integrins are major cell adhesion receptors which assume two important functions: first they act as anchoring molecules allowing firm cellular attachment to the extracellular matrix, and second they work as signalling receptors being able to transduce signals in both directions (outside-in and inside-out) through the plasma membrane. Their biological importance is determined by their involvement in many physiological phenomena. Furthermore, their implication in various diseases and their accessibility to drugs make them interesting therapeutic targets. [less ▲]

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See detailBook review of : V. PRESS, Das Alte Reich. Ausgewählte Aufsätze, 1997
Weis, Monique UL

in Revue Belge de Philologie et d'Histoire (2003), 81

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See detailAcoustic profilometry within polymers as performed by Brillouin microscopy
Sanctuary, Roland UL; Bactavatchalou, R.; Müller, Ulrich UL et al

in Journal of Physics : D Applied Physics (2003), 36(21), 2738-2742

Using high performance Brillouin spectroscopy we present a new technique, which enables us to perform acoustic microscopy with a spatial resolution of about 1 μm. This technique, called Brillouin ... [more ▼]

Using high performance Brillouin spectroscopy we present a new technique, which enables us to perform acoustic microscopy with a spatial resolution of about 1 μm. This technique, called Brillouin microscopy, is tested on several bulk- and film-like polymer samples. [less ▲]

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See detailSpin relaxation in a complex environment
Esposito, Massimiliano UL; Gaspard, P.

in Physical Review. E. (2003), 68(6),

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See detailPsychophysiologic effects of applied tension on the emotional fainting response to blood and injury.
Vögele, Claus UL; Coles, Justine; Wardle, Jane et al

in Behaviour research and therapy (2003), 41

OBJECTIVE: The present study was designed to investigate the psychophysiologic effects of "Applied Tension" (AT) on the emotional fainting response to blood and injury in a controlled experiment. METHOD ... [more ▼]

OBJECTIVE: The present study was designed to investigate the psychophysiologic effects of "Applied Tension" (AT) on the emotional fainting response to blood and injury in a controlled experiment. METHOD: Twenty-two persons reporting to generally feel faint or to have fainted at the sight of blood or injury and 22 participants classified as Non-Fainters were randomly allocated to a treatment or control condition. Psychophysiologic responses were continuously monitored while individuals watched a video depicting open-heart surgery and a control film. Prior to the surgery film, participants in the treatment condition were instructed in the use of AT. RESULTS: All participants classified as Fainters showed a diphasic response pattern while watching the surgery film. This response, however, was significantly attenuated in Fainters in the treatment condition. CONCLUSIONS: These results suggest that AT provides an effective treatment strategy for the prevention of fainting responses in persons with a fear of blood and injury. [less ▲]

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See detailQuantum master equation for a system influencing its environment
Esposito, Massimiliano UL; Gaspard, P.

in Physical Review. E. (2003), 68(6),

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See detailHigher genus affine Lie algebras of Krichever-Novikov type
Schlichenmaier, Martin UL

in Moscow Mathematical Journal (2003), 3

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See detail‘C'est canard’ – ‘C'est un vert’. Der Artikelgebrauch im frühen gesteuerten Erwerb des Französischen
Ziegler, Gudrun UL; Mutz, Katrin

in Zeitschrift für Literaturwissenschaft und Linguistik [= LiLi] (2003), 33(131), 76-105

At an early stage of instructed foreign language learning (French), young learners develop a simplest language which reflects similarities with adult learner varieties, Creole systems and strategies of ... [more ▼]

At an early stage of instructed foreign language learning (French), young learners develop a simplest language which reflects similarities with adult learner varieties, Creole systems and strategies of (first) language acquisition. Due to the fact that their L1 (German) has still to be extended, especially in terms of the written variety, learners interact in an environment with specific language use. Considering young learners language production, examples of article use in instructed interaction were investigated. [less ▲]

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See detailSecurity Council Resolution 1373 and the Constitution of the United Nations
Happold, Matthew UL

in Leiden Journal of International Law (2003), 16

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See detailDie Bedeutung der Philosophie für einen Theologen
Weber, Jean-Marie UL

in Nos Cahiers (2003), 1

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See detailTeacher reflection in a hall of mirrors: Historical influences and political reverberations
Fendler, Lynn UL

in Educational Researcher (2003), 32(3), 16-25

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See detailAutomutilation révoltée ou expression culturelle ? Le cas du body piercing à Rome
Reckinger, Rachel UL

in Quasimodo (2003), 7

Le marquage des chairs à des fins esthétiques, identitaires ou politiques (tatouages, piercings, scarifications, implants, amputations, etc.), la chirurgie, le transsexualisme, les biotechnologiques ... [more ▼]

Le marquage des chairs à des fins esthétiques, identitaires ou politiques (tatouages, piercings, scarifications, implants, amputations, etc.), la chirurgie, le transsexualisme, les biotechnologiques, l’entraînement sportif et le dopage, constituent autant de pratiques visant à modifier un corps qu’il s’agit d’amplifier, d’embellir, de réparer ou d’altérer. Ces effractions parfois radicales, ces blessures volontaires, ces inscriptions éphémères ou définitives, visibles ou secrètes, posent la question de l’acceptable et du respect de la norme corporelle. Elles ouvrent la perspective concrète d’esquiver ou d’infléchir le destin biologique et social. Les stratégies identitaires s’incarnent alors dans l’effacement ou la revendication des différences, la quête ou le refus des canons esthétiques. [less ▲]

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See detailDie Virtuelle Hauptversammlung - Momentaufnahme und Ausblick
Zetzsche, Dirk Andreas UL

in Zeitschrift für Bank- und Kapitalmarktrecht (2003)

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See detailOpfer werden im Kontext fremdenfeindlicher Gewalt: Gewalttätige Übergriffe trotz beschwichtigendem Opferverhalten.
Steigleder, Sandra; Willems, Helmut UL

in Zeitschrift für Gewaltprävention (2003)

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See detailMutation analysis of the neurofilament M gene in Parkinson's disease.
Krüger, Rejko UL; Fischer, Christian; Schulte, Thorsten et al

in Neuroscience Letters (2003), 351(2), 125-9

Neurofilament M, a major component of Lewy bodies, represents an interesting candidate in the pathogenesis of Parkinson's disease (PD). We performed detailed mutation analyses of the NF-M gene in 322 ... [more ▼]

Neurofilament M, a major component of Lewy bodies, represents an interesting candidate in the pathogenesis of Parkinson's disease (PD). We performed detailed mutation analyses of the NF-M gene in 322 familial and sporadic PD patients. Two polymorphisms (Ala475Thr and Gly697Arg) occurred at similar frequencies in PD patients and controls. A Pro725Gln substitution and a deletion of valine in position 829 were identified in two PD patients. These substitutions affect residues of the NF-M protein that are highly conserved among different species. None of our patients carried the Gly336Ser substitution, which has been described in familial PD. Our results argue against a major role of NF-M in PD. However, rare variants of the NF-M gene may act as susceptibility factors for PD and functional analyses of the identified variations are warranted to decipher possible mechanisms in neurodegeneration. [less ▲]

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See detailLe testing adaptatif par ordinateur dans la mesure en éducation: potentialités et limites
Martin, Romain UL

in Psychologie et Psychométrie (2003), 24(2-3), 89-116

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See detailLa prostitution à Bruxelles pendant la Grande Guerre: contrôle et pratique
Majerus, Benoît UL

in Crime, Histoire & Sociétés (2003), 7(1), 5--42

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See detailLogiques administratives et persécution anti-juive. La police bruxelloise et les arrestations de 1942
Majerus, Benoît UL

in Cahiers d'Histoire du Temps Présent = Bijdragen tot de Eigentijdse Geschiedenis (2003), (12), 181--217

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See detailDie Beziehung zum Schüler Eine ethische Herausforderung für Lehrende
Weber, Jean-Marie UL

in Forum für Politik, Gesellschaft und Kultur in Luxemburg (2003)

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See detailForum Comment
König, Ariane UL

in Science and Technology (2003), XX

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See detailThe actin cytoskeleton as a therapeutic target: state of the art and future directions.
Giganti, Adeline; Friederich, Evelyne UL

in Progress in cell cycle research (2003), 5

Dynamic processes such as cell migration and division depend on the actin cytoskeleton, a dense meshwork of protein polymers capable of undergoing rapid cycles of assembly and disassembly, under the ... [more ▼]

Dynamic processes such as cell migration and division depend on the actin cytoskeleton, a dense meshwork of protein polymers capable of undergoing rapid cycles of assembly and disassembly, under the control of a large number of actin-associated proteins. In cancer cells, structural and functional perturbations of the actin cytoskeleton correlate with higher proliferation rates and uncontrolled movement. Therefore, small molecules that act on the actin cytoskeleton of tumour cells and thus inhibit cell division and movement, may be of high therapeutic value. The dynamic properties of the actin cytoskeleton and the mechanism of action of actin-targeting drugs will be described. [less ▲]

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See detailAT2 receptor activation regulates myocardial eNOS expression via the calcineurin-NF-AT pathway.
Ritter, Oliver; Schuh, Kai; Brede, Marc et al

in FASEB Journal (2003), 17(2), 283-5

The role of AT2-receptors has recently been subject of considerable debate. We investigated the influence of AT2-stimulation/inhibition on myocardial endothelial NO-synthase (eNOS, NOS-III) promoter ... [more ▼]

The role of AT2-receptors has recently been subject of considerable debate. We investigated the influence of AT2-stimulation/inhibition on myocardial endothelial NO-synthase (eNOS, NOS-III) promoter activity and eNOS protein expression. Stimulation of rat cardiomyocytes with angiotensin II (AngII) increased eNOS protein expression 3.3-fold. This was blocked by Cyclosporin A (CsA). Inhibition of the AT1-receptor did not reduce AngII-mediated eNOS protein expression, whereas AT2 stimulation increased it 2.4-fold and AT2 inhibition suppressed it. The modulatory effects of the AT2-receptor on eNOS expression was confirmed in mice with a genetic deletion of the AT2-receptor (AT2-KO). In gel shift assays two putative NF-AT sites in a 1.6 kb eNOS promoter fragment showed NF-AT binding and a supershift by NF-AT2(-c1)-specific antibodies. Stimulation of transfected cells with AngII or specific AT2-receptor agonists resulted in a significant increase in eNOS promoter activity, which was blocked by CsA, MCIP1, and mutation of an upstream NF-AT site. CONCLUSION: 1) AngII-stimulation of the myocardium, both in vivo and in vitro, is accompanied by increased expression of eNOS. 2) This effect is mediated by the calcineurin pathway and is induced by the AT2-receptor. 3) These results define a calcineurin/NF-AT/eNOS pathway as downstream effector of AT2-receptor activation in the myocardium. [less ▲]

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See detailSemiclassical theory for transmission through open billiards: Convergence towards quantum transport
Wirtz, Ludger UL; Stampfer, C.; Rotter, S. et al

in Physical Review. E. (2003), 67(1),

We present a semiclassical theory for transmission through open quantum billiards which converges towards quantum transport. The transmission amplitude can be expressed as a sum over all classical paths ... [more ▼]

We present a semiclassical theory for transmission through open quantum billiards which converges towards quantum transport. The transmission amplitude can be expressed as a sum over all classical paths and pseudopaths which consist of classical path segments joined by "kinks," i.e., diffractive scattering at lead mouths. For a rectangular billiard we show numerically that the sum over all such paths with a given number of kinks K converges to the quantum transmission amplitude as K-->infinity. Unitarity of the semiclassical theory is restored as K approaches infinity. Moreover, we find excellent agreement with the quantum path-length power spectrum up to very long path length. [less ▲]

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See detailStudio europeo ESAW (european study on adult well-being): il ruolo della salute fisica e dello stato funzionale per la qualità della vita in età adulta e anziana
Barbagallo, M.; Spazzafumo, L.; Balducci, Christian et al

in Giornale di Gerontologia (2003)

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See detailEthik ohne Theorie. Zum Problem der Moralbegründung
Heidemann, Dietmar UL

in Allgemeine Zeitschrift für Philosophie (2003), 28

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See detailUltrafast and highly sensitive photodetectors fabricated on high-energy nitrogen-implanted GaAs,
Mikulics, M.; Marso, Michel UL; Kordoš, P. et al

in Applied Physics Letters (2003), 83

We have fabricated and tested metal–semiconductor–metal ~MSM! photodetectors based on nitrogen-ion-implanted GaAs. Nitrogen ions with energy of 700 and 880 keV, respectively, were implanted into epitaxial ... [more ▼]

We have fabricated and tested metal–semiconductor–metal ~MSM! photodetectors based on nitrogen-ion-implanted GaAs. Nitrogen ions with energy of 700 and 880 keV, respectively, were implanted into epitaxial GaAs films at an ion concentration of 331012 cm22. Ti/Au MSM photodetectors with 1-um-wide fingers were fabricated on top of the implanted GaAs. In comparison to low-temperature-grown GaAs photodetectors, produced in parallel in identical MSM geometry, the 880 keV N1-implanted photodetectors exhibited almost two orders of magnitude lower dark current ~10 nA at 1 V bias! and the responsivity more than doubled ~.20 mA/W at 20 V bias!. Illumination with 100-fs-wide, 810 nm wavelength laser pulses, generated ;2.5-ps-wide photoresponse signals with amplitudes as high as 2 V. The 2.5 ps relaxation time was the same for both the ion-implanted and low-temperature-grown devices and was limited by the MSM capacitance time constant. [less ▲]

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See detailTargeted disruption of the peptide transporter Pept2 gene in mice defines its physiological role in the kidney.
Rubio-Aliaga, Isabel; Frey, Isabelle; Boll, Michael et al

in Molecular and Cellular Biology (2003), 23(9), 3247-52

The peptide transporter PEPT2 mediates the cellular uptake of di- and tripeptides and selected drugs by proton-substrate cotransport across the plasma membrane. PEPT2 was functionally identified initially ... [more ▼]

The peptide transporter PEPT2 mediates the cellular uptake of di- and tripeptides and selected drugs by proton-substrate cotransport across the plasma membrane. PEPT2 was functionally identified initially in the apical membrane of renal tubular cells but was later shown to be expressed in other tissues also. To investigate the physiological importance of PEPT2 and for a detailed analysis of the protein expression sites, we generated a Pept2 knockout mouse line in which the Pept2 gene was disrupted by insertion of a beta-galactosidase gene under the control of the PEPT2 promoter. The Pept2(-/-) mice showed no obvious phenotypic abnormalities but also no adaptive upregulation in the expression level of related genes in the kidney. The importance of PEPT2 in the reabsorption of filtered dipeptides was demonstrated in knockout animals by significantly reduced renal accumulation of a fluorophore-labeled and a radiolabeled dipeptide after in vivo administration of the tracers. This indicates that PEPT2 is the main system responsible for tubular reabsorption of peptide-bound amino acids, although this does not lead to major changes in renal excretion of protein or free amino acids. [less ▲]

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See detailThe Discourse of German Geisteswissenschaftliche Pädagogik - A Contextual Reconstruction
Tröhler, Daniel UL

in Paedagogica Historica (2003), XXXIX(6), 759-778

The framework of German educational discourse of the twentieth century is so-called geisteswissenschaftliche Pädagogik, or education as one of the humanities or arts rather than as a science. It triumphed ... [more ▼]

The framework of German educational discourse of the twentieth century is so-called geisteswissenschaftliche Pädagogik, or education as one of the humanities or arts rather than as a science. It triumphed around 1925 in the second half of the Weimar Republic. This article outlines in three steps the core elements of this educational discourse. [less ▲]

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See detailAkt modulates STAT3-mediated gene expression through a FKHR (FOXO1a)-dependent mechanism
Kortylewski, M.; Feld, F.; Krüger, K. D. et al

in Journal of Biological Chemistry (2003), 278(7), 5242-9

The phosphatidylinositol 3-kinase/Akt pathway plays an important role in the signaling of insulin and other growth factors, which reportedly attenuate the interleukin-6 (IL-6)-mediated stimulation of ... [more ▼]

The phosphatidylinositol 3-kinase/Akt pathway plays an important role in the signaling of insulin and other growth factors, which reportedly attenuate the interleukin-6 (IL-6)-mediated stimulation of acute phase plasma protein genes. We investigated the effect of the protein kinase Akt on IL-6-mediated transcriptional activation. The transient expression of constitutively active Akt inhibited the IL-6-dependent activity of the alpha(2)-macroglobulin promoter in HepG2 cells, whereas expression of an inactive mutant of phosphatidylinositol-dependent kinase 1 had the opposite effect. Since Akt is known to regulate gene expression through inactivation of the transcription factor FKHR (forkhead in rhabdomyosarcoma), we examined the effect of FKHR on STAT3-mediated transcriptional regulation. Indeed, the overexpression of FKHR specifically enhanced the activity of STAT3-dependent promoters but not that of a STAT5-responsive promoter. The effect of FKHR required the presence of functional STAT3 and was abrogated by the expression of dominant negative STAT3 mutants. Furthermore, FKHR and STAT3 were shown to coimmunoprecipitate and to colocalize in the nuclear regions of IL-6-treated HepG2 cells. Our results indicate that FKHR can modulate the IL-6-induced transcriptional activity by acting as a coactivator of STAT3. [less ▲]

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See detailInstruction or educating for life? On the aims of religiously affiliated and other schools.
Miedema, S.; Biesta, Gert UL

in International Journal of Education and Religion (2003), 4(1), 81-96

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See detailEffect of surface passivation on performance of AlGaN/GaN/Si HEMTs
Bernát, J.; Javorka, P.; Fox, A. et al

in Solid-State Electronics (2003), 47((2003)), 2097-2103

Performance of intentionally undoped and doped AlGaN/GaN/Si high electron mobility transistors (HEMTs) before and after passivation with SiO2 and Si3N4 is investigated. Hall effect measurements show ... [more ▼]

Performance of intentionally undoped and doped AlGaN/GaN/Si high electron mobility transistors (HEMTs) before and after passivation with SiO2 and Si3N4 is investigated. Hall effect measurements show higher impact of Si3N4 than SiO2 passivation on the carrier concentration increase in the channel. Improvements in DC performance of HEMTs after passivation with SiO2 and Si3N4 correspond to the changes in sheet carrier concentration. Small signal microwave characterisation shows a decrease (from 18.6 to 9 GHz) and an increase (from 18.4 to 28.8 GHz) of the current gain cut off frequency after SiO2 and Si3N4 passivation, respectively. Similar effect of passivation is found in microwave power changes––only about a half of the power is obtained after SiO2 passivation but more than doubled power results from Si3N4 passivation, measured at 2 GHz. Higher density of interface states for SiO2 than Si3N4 passivation is supposed to be responsible for these effects. However, for an optimal design of GaN-based power devices additional studies related to the interface between a passivation layer and GaN are needed. [less ▲]

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See detailInvestigation of hydrological and atmospheric loading by space geodetic techniques
Schuh, H.; Eastermann, G.; Cretaux, J.-F. et al

in International Association of Geodesy Symposia (2003), 126

Observations of sea level can only be interpreted correctly if land motion in particular in terms of vertical deformation of coastal areas is taken into account. In the last decades space geodetic ... [more ▼]

Observations of sea level can only be interpreted correctly if land motion in particular in terms of vertical deformation of coastal areas is taken into account. In the last decades space geodetic techniques such as VLBI (Very Long Baseline Interferometry), SLR (Satellite Laser Ranging), the GPS (Global Positioning System), and Doris (Doppler Orbitography and Radio positioning Integrated by Satellite) have proved to be very powerful for determining displacements of points on the solid Earth. These can be modeled by using various geodynamical parameters, e.g. the Love and Shida numbers in the model of the solid Earth tides and site-dependent amplitudes and phases of the ocean loading models. Today, the small deformations associated with the response of the Earth to atmospheric and hydrological loading are of growing interest. These effects cause site-dependent vertical displacements with ranges up to ±30mm due to atmospheric pressure variations and due to mass redistribution in surface fluid envelopes, in particular in continental water reservoirs (soil moisture, snow, and groundwater). Several new global and regional models of soil moisture and snow depths are now available and can be validated by space geodetic techniques. This paper is intended to give a short overview about state-of-the-art of modeling loading effects. A short introduction to the Special Bureau for Loading within the Global Geophysical Fluid Center (GGFC) of the IERS will be given, too. Finally, it will be shown how the effects influence the results of high precision space geodetic measurements. The paper mainly concentrates on vertical crustal motions on seasonal and interannual time scales observed by VLBI and describes also some results obtained from Doris. [less ▲]

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See detailGrundfälle zum Europarecht - 4. Teil (Europäisches Prozessrecht)
Cole, Mark UL; Haus, Florian C.

in Juristische Schulung : Zeitschrift für Studium und Referendariat (2003)

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See detailRezension: Fred Karl (Hrsg.): Sozial- und Verhaltenswissenschaftliche Gerontologie
Karl, Ute UL

in Sozialwissenschaftliche Literatur Rundschau (2003), 26(47), 118-120

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See detailAn approach for dividing models of biological reaction networks into functional units
Ederer, M.; Sauter, Thomas UL; Bullinger, E. et al

in Simulation (2003), 79

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See detailMolecular dynamics simulation of the unfolding of the human prion protein domain under low pH and high temperature conditions
Gu, Wei UL; Wang, T. T.; Zhu, J. et al

in Biophysical Chemistry (2003), 104(1), 79-94

Four 10-ns molecular dynamics (MD) simulations of the human prion protein domain (HuPrP 125-228) in explicit water solution have been performed. Each of the simulations mimicked a different environment of ... [more ▼]

Four 10-ns molecular dynamics (MD) simulations of the human prion protein domain (HuPrP 125-228) in explicit water solution have been performed. Each of the simulations mimicked a different environment of the protein: the neutral pH environment was simulated with all histidine residues neutral and bearing a ND proton and with other titratable side chains charged, the weakly acidic environment was simulated with all titratable side chains charged, he strongly acidic environment was simulated with all titratable side chains protonated. The protein in neutral pH environment was simulated at both ambient (298 K) and higher (350 K) temperatures. The native fold is stable in he neutral pH/ambient temperature simulation. Through out all other simulations, a quite stable core consisted of 0-20 residues around the disulfide bond retain their initial conformations. However, the secondary structures of the Protein show changes of various degrees compared to the native fold, parts of the helices unfolded and the beta-sheets extended. Our simulations indicated that the heat-induced unfolding and acid-induced unfolding of HuPrP might follow different pathways: the initial stage of the acid-induced unfolding may include not only changes in secondary structures, but also changes in the tertiary structures. Under the strongly acidic condition, obvious tertiary structure changes take place after 10-ns simulation, the secondary structure elements and the loops becoming more parallel to each other, resulting in a compact state, which was stabilized by a large number of new, non-native side chain-side chain contacts. Such tertiary structure changes were not observed in the higher temperature simulation, and intuitively, they may favor the further extension of the beta-sheets and eventually the agglomeration of multiple protein molecules. The driving forces for this tertiary structure changes are discussed. Two additional 10-ns MD simulations, one with Asp202 protonated and the other with Glu196 protonated compared to the neutral pH simulation, were carried out. The results showed that the stability of the native fold is very subtle and can be strongly disturbed by eliminating a single negative charge at one of such key sites. Correlations of our results with previous experimental and theoretical studies are discussed. (C) 2003 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailTherapeutic strategies for Parkinson's disease based on data derived from genetic research.
Riess, Olaf; Berg, Daniela; Krüger, Rejko UL et al

in Journal of neurology (2003), 250 Suppl 1

Following the identification of mutations in alpha-synuclein as the cause of some rare forms of familial Parkinson's disease (PD), genetic research has uncovered numerous gene loci of PD. Meanwhile ... [more ▼]

Following the identification of mutations in alpha-synuclein as the cause of some rare forms of familial Parkinson's disease (PD), genetic research has uncovered numerous gene loci of PD. Meanwhile, several neurodegenerative diseases have been shown to accumulate a-synuclein in neuronal and glial cells summarizing this group of diseases as synucleinopathies. All currently known gene defects causing PD alter the ubiquitin-proteasomal pathway of protein degradation. Identification of these disease mutations allows studying the functional consequences which lead to cellular dysfunction and cell death in cell culture and transgenic animal models, to identify therapeutic targets and to test potential protective strategies in these models. [less ▲]

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See detailTranscoding zeros within complex numerals.
Grana, Alessia; Lochy, Aliette UL; Girelli, Luisa et al

in Neuropsychologia (2003), 41(12), 1611-8

This paper describes a patient (LD) showing a selective syntactic deficit in the production of Arabic numerals. Unlike in previously reported cases, LD's syntactic difficulties result in deletions rather ... [more ▼]

This paper describes a patient (LD) showing a selective syntactic deficit in the production of Arabic numerals. Unlike in previously reported cases, LD's syntactic difficulties result in deletions rather than insertions of zeros, with a reduction of the number magnitude. The pattern of errors highlighted a distinction between "lexical zeros", i.e. the zeros in tens, that are semantically derived, and "syntactic zeros" that are syntactically produced as the result of specific production rules. In LD, only syntactic zeros were affected. Furthermore, the processing of numerals with final zeros was found to be easier than the processing of numerals with internal zeros. This pattern of errors is compatible with the lexical-semantic model of Power and Dal Martello. In this model, in fact, lexical zeros originate from a numerical concept, while syntactic zeros originate from a concatenation operation, plus an overwriting operation leaving one or more intermediary zeros. Thus, lexical zeros may be easier to manipulate than syntactic zeros that merely represent a null quantity associated to a specific power of 10. [less ▲]

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See detailGrundfälle zum Europarecht - 5. Teil (Grundfreiheiten und Diskriminierungsverbot)
Cole, Mark UL; Haus, Florian C.

in Juristische Schulung : Zeitschrift für Studium und Referendariat (2003)

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See detailReview of M. Gymnich, A. and V. Nuenning. (eds) Literature and Linguistics: Approaches, Models, and Applications
Weber, Jean-Jacques UL

in BELL. Belgian Journal of English Language and Literatures (2003), 12

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See detailWie genau sind alte Landkarten der Eifel?
Solchenbach, Karl UL

in Heimatkalender Bitburg-Prüm (2003)

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See detailUtilisation des modules elliptiques de Drinfeld en cryptologie
Gillard, Roland; Leprévost, Franck UL; Pantchichkine, Alexei et al

in Comptes Rendus. Mathématique (2003), 336(11), 879-882

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See detailCréation de l'autorité des marchés financiers
Conac, Pierre-Henri UL

in Revue de Droit Bancaire et Financier (2003), (5), 299-299

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See detailÉtude critique de la notion de patrimoine en droit privé actuel
Hiez, David UL

in Bibliothèque de droit privé (2003), 399

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See detailTrajectoires sur 5 ans et dépendance aux psychotropes de consommateurs de la cinquantaine.
Alla, François; Baumann, Michèle UL

in Thérapie (2003), 58(2), 145-151

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See detailWeighted Group Algebras on Groups of Polynomial Growth
Fendler, Gero; Gröchenig, Karlheinz; Leinert, Michael et al

in Mathematische Zeitschrift (2003), 245(4), 791-821

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See detailPhysics of imaging p-n junctions by scanning tunneling microscopy and spectroscopy
Jäger, N. D.; Marso, Michel UL; Salmeron, M. et al

in Physical Review. B, Condensed Matter (2003), ((2003)), 165307

Combined voltage-dependent scanning tunneling microscopy ~STM! images with atomic resolution, local scanning tunneling spectroscopy, and simulations of the potential distribution in the interface STM tip ... [more ▼]

Combined voltage-dependent scanning tunneling microscopy ~STM! images with atomic resolution, local scanning tunneling spectroscopy, and simulations of the potential distribution in the interface STM tip system are used to extract the physical imaging mechanisms of GaAs p-n interfaces in STM images. It is shown that ~i! the tip-induced changes of the potential near the interface result in the tunneling characteristics of the p-type (n-type! layer being dragged into the interfaces’ depletion region at positive ~negative! sample voltage. ~ii! This leads to a considerable reduction of the apparent width of the image of the depletion zone in STM images. ~iii! At small negative sample voltages, a pronounced depression line appears. The depression is directly correlated with the electronic interface. It arises from the interplay of competing current contributions from the valence and conduction bands. This understanding of the imaging process allows us to develop methods on how to extract accurate physical data about the properties of the electronic interfaces from scanning tunneling microscopy images. [less ▲]

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