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See detailThe New French Preferred Shares: Moving towards a More Liberal Approach
Conac, Pierre-Henri UL

in European Company and Financial Law Review (2005), 2(4), 487

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See detailRegions of stability for limit cycle oscillations in piecewise linear systems
Goncalves, Jorge UL

in IEEE Transactions on Automatic Control (2005), 50(11), 1877-1882

Oscillations appear in numerous applications from biology to technology.However, besides local results, rigorous stability and robustness analysis of oscillations are rarely done due to their intrinsic ... [more ▼]

Oscillations appear in numerous applications from biology to technology.However, besides local results, rigorous stability and robustness analysis of oscillations are rarely done due to their intrinsic nonlinear behavior. Poincarémaps associated with the system cannot typically be found explicitly and stability is estimated using extensive simulations and experiments. This paper gives conditions in the form of linear matrix inequalities (LMIs) that guarantee asymptotic stability in a reasonably large region around a limit cycle for a class of systems known as piecewise linear systems (PLS). Such conditions, based on recent results on impact maps and surface Lyapunov functions (SuLF), allow a systematic and efficient analysis of oscillations of PLS or arbitrarily close approximations of nonlinear systems by PLS. The methodology applies to any locally stable limit cycle of a PLS, regardless of the dimension and the number of switching surfaces of the system, and is illustrated with a biological application: a fourth-order neural oscillator, also used in many robotics applications such as juggling and locomotion. [less ▲]

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See detailKnowledge and behaviour of tourists towards the sun, as studied in a region of northern Greece
Argyriadou, Stella; Makridis, Dimitrios; Lygidakis, Charilaos UL et al

in Rural and Remote Health (2005)

Introduction: Melanoma is considered one of the most malignant cancers. Its appearance is related to various factors such as ultraviolet radiation, recurrent sunburn, and phototype. During the summer ... [more ▼]

Introduction: Melanoma is considered one of the most malignant cancers. Its appearance is related to various factors such as ultraviolet radiation, recurrent sunburn, and phototype. During the summer holidays approximately 14 million tourists from northern European countries visit Greece; this does not include the local tourists. Aims: To discover the extent of European visitors’ awareness of the risk of sunburn. To explore the level of knowledge gained by local and foreign tourists from preventive campaigns related to the harmful effects of sun exposure. Participants: The sample consisted of 802 travelers from northern European countries, and 726 Greeks who departed from the airport ‘Megas Alexandros’ during August and September 2002. Methods: A structured questionnaire was used to gain data about demographics, family history of skin cancer, and identification of phototype. Also requested was information about the hours of sun exposure, and the use of sunscreen (the pattern of application and its sun protective factor [SPF]). Comparisons of mean values between groups were made by Student’s t-test, and the association between categorical variables was tested by Pearson’s c2. Regression analysis was performed to examine the influence of different factors on the likelihood of being sunburned. Results: The majority of foreigners belonged to phototype II or III, while the Greek tourists belonged to phototype III. Foreigners had a higher tendency to burn and a lower tendency to tan. Of the total sample, women presented a higher prevalence of sunburn (p <0.05), and they used sunscreen more frequently (p <0.001) than men did (p <0.001), in both groups. The mean SPF used was 17.3 (SD = 8.98) for the foreigners and 16.0 (SD = 2.0) for the Greeks. The media was the main source of information for both groups. Multiple regression analysis showed that skin type was significantly associated with a high probability of sunburn (p <0.001). Moreover, freckles (p <0.05) were a predictive factor for future sunburn. Conclusions: Our study showed that skin type is the most important predictor of future sunburn. The role of the primary care physician is to promote and encourage healthy habits, including attitude towards sun exposure. Increased susceptibility to sun-induced damage of persons with phototypes I and II mandates their identification as a target group in all media campaigns. [less ▲]

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See detailSelbstkontrolliertes Üben von Bewegungsfertigkeiten: Aktueller Forschungsstand und ein antagonistisches Modell
Bund, Andreas UL; Wiemeyer, Josef

in Spectrum der Sportwissenschaften (2005), 17(2), 8-25

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See detailResponsive Environments, Place and Presence
McCall, Roderick UL; O'Neill, Shaleph; Carroll, Fiona et al

in PsychNology Journal (2005), 3(1), 35-73

This paper examines the effect that changing arena (i.e. an immersive CAVE or head mounted display) and adding an augmented barrier has on the sense of place and presence in two photo-realistic virtual ... [more ▼]

This paper examines the effect that changing arena (i.e. an immersive CAVE or head mounted display) and adding an augmented barrier has on the sense of place and presence in two photo-realistic virtual environments. Twenty eight subjects (17 male, 11 female) mainly undergraduate students or staff took part. The paper summarises two experiments that used a range of data capture methods including the place probe, semantic differentials, distance estimates and the MEC Questionnaire. The results indicate that in non-interactive photo-realistic environments the choice of arena has an impact on the perceived ability to undertake actions, and hence sense of place and presence; with the CAVE providing a lower sense of spatial presence for certain aspects than the HMD. [less ▲]

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See detailA field guide of their own
Siry, Christina UL; Buchinski, Lisa, C.

in Science and Children (2005), 43(1), 36-39

The article presents information on the use of natural outdoor settings to develop and encourage children's appreciation and ownership of their natural environment. Whenever students were outdoors, they ... [more ▼]

The article presents information on the use of natural outdoor settings to develop and encourage children's appreciation and ownership of their natural environment. Whenever students were outdoors, they invariably asked to know the names of what they saw. Rather than simply recite plant and animal names., we pointed out identifiable features in a plant or animal and then taught students to use field guides to find out more. A project was planned for the students to teach the integration of arts and science into other disciplines and there connections to the world around them. Throughout the school year, activities in science focused on developing students' science-process skills, and this particular project focused on the skills of observing and comparing. One hundred twenty five second-and third-grade students participated in the month-long project. This age group was chosen for practical reasons: first, because their schedule went from art to science, or vice versa. This allowed for a block of an hour and a half for each student, rather than the usual 45-minute time period. Second, it was felt that this age group would be developmentally able to make generalizations about habitats and plant requirements while focusing on small differences between species. [less ▲]

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See detailWie lernen Jugendliche "ihren" Sport? Beobachtungen im Freizeitsportmilieu
Bund, Andreas UL

in Bewegungserziehung (2005), 59(4), 16-20

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See detailL'incidence de l'introduction des actions de préférence sur le droit coopératif
Hiez, David UL

in Droit des sociétés (2005), (8), 7-10

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See detailSpatio-temporal activation of chromatin on the human CYP24 gene promoter in the presence of 1alpha,25-Dihydroxyvitamin D3
Väisänen, Sami; Dunlop, Thomas W.; Sinkkonen, Lasse UL et al

in Journal of Molecular Biology (2005), 350(1), 65-77

The vitamin D3 24-hydroxylase gene (CYP24) is one of the most strongly induced genes known. Despite this, its induction by the hormone 1alpha,25-dihydroxyvitamin D3 (1alpha,25OH2D3) has been characterized ... [more ▼]

The vitamin D3 24-hydroxylase gene (CYP24) is one of the most strongly induced genes known. Despite this, its induction by the hormone 1alpha,25-dihydroxyvitamin D3 (1alpha,25OH2D3) has been characterized only partially. Therefore, we monitored the spatio-temporal, 1alpha,25OH2D3-dependent chromatin acetylation status of the human CYP24 promoter by performing chromatin immunoprecipitation (ChIP) assays with antibodies against acetylated histone 4. This was achieved by performing PCR on 25 contiguous genomic regions spanning the first 7.7 kb of the promoter. ChIP assays using antibodies against the 1alpha,25OH2D3 receptor (VDR) revealed that, in addition to the proximal promoter, three novel regions further upstream associated with VDR. Combined in silico/in vitro screening identified in three of the four promoter regions sequences resembling known VDREs and reporter gene assays confirmed the inducibility of these regions by 1alpha,25OH2D3)=. In contrast, the fourth VDR-associated promoter region did not contain any recognizable classical VDRE that could account for the presence of the protein on this region. However, re-ChIP assays monitored on all four promoter regions simultaneous association of VDR with retinoid X receptor, coactivator, mediator and RNA polymerase II proteins. These proteins showed a promoter region-specific association pattern demonstrating the complex choreography of the CYP24 gene promoter activation over 300 minutes. Thus, this study reveals new information concerning the regulation of the CYP24 gene by 1alpha,25OH2D3, and is a demonstration of the simultaneous participation of multiple, structurally diverse response elements in promoter activation in a living cell. [less ▲]

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See detailAn axiomatic approach to the definition of the entropy of a discrete Choquet capacity
Kojadinovic, Ivan; Marichal, Jean-Luc UL; Roubens, Marc

in Information Sciences (2005), 172(1-2), 131-153

To extend the classical Shannon entropy to non-additive measures, Marichal recently introduced the concept of generalized entropy for discrete Choquet capacities. We provide a first axiomatization of this ... [more ▼]

To extend the classical Shannon entropy to non-additive measures, Marichal recently introduced the concept of generalized entropy for discrete Choquet capacities. We provide a first axiomatization of this new concept on the basis of three axioms: the symmetry property, a boundary condition for which the entropy reduces to the Shannon entropy, and a generalized version of the well-known recursivity property. We also show that this generalized entropy fulfills several properties considered as requisites for defining an entropy-like measure. Lastly, we provide an interpretation of it in the framework of aggregation by the discrete Choquet integral. [less ▲]

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See detailA complete description of comparison meaningful functions
Marichal, Jean-Luc UL; Mesiar, Radko; Rückschlossová, Tatiana

in Aequationes Mathematicae (2005), 69(3), 309-320

Comparison meaningful functions acting on some real interval E are completely described as transformed coordinate projections on minimal invariant subsets. The case of monotone comparison meaningful ... [more ▼]

Comparison meaningful functions acting on some real interval E are completely described as transformed coordinate projections on minimal invariant subsets. The case of monotone comparison meaningful functions is further specified. Several already known results for comparison meaningful functions and invariant functions are obtained as consequences of our description. [less ▲]

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See detailThe horizontal failure mechanism of the Wilnis peat dike
Van Baars, Stefan UL

in Geotechnique (2005), 55(4), 319-323

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See detailRegulation of the human cyclin C gene via multiple vitamin D3-responsive regions in its promoter
Sinkkonen, Lasse UL; Malinen, Marjo; Saavalainen, Katri et al

in Nucleic Acids Research (2005), 33(8), 2440-51

The candidate human tumor suppressor gene cyclin C is a primary target of the anti-proliferative hormone 1alpha,25-dihydroxyvitamin D3 [1alpha,25(OH)2D3], but binding sites for the 1alpha,25(OH)2D3 ... [more ▼]

The candidate human tumor suppressor gene cyclin C is a primary target of the anti-proliferative hormone 1alpha,25-dihydroxyvitamin D3 [1alpha,25(OH)2D3], but binding sites for the 1alpha,25(OH)2D3 receptor (VDR), so-called 1alpha,25(OH)2D3 response elements (VDREs), have not yet been identified in the promoter of this gene. We screened various cancer cell lines by quantitative PCR and found that the 1alpha,25(OH)2D3 inducibility of cyclin C mRNA expression, in relationship with the 24-hydroxylase (CYP24) gene, was best in MCF-7 human breast cancer cells. To characterize the molecular mechanisms, we analyzed 8.4 kb of the cyclin C promoter by using chromatin immunoprecipitation assays (ChIP) with antibodies against acetylated histone 4, VDR and its partner receptor, retinoid X receptor (RXR). The histone 4 acetylation status of all 23 investigated regions of the cyclin C promoter did not change significantly in response to 1alpha,25(OH)2D3, but four independent promoter regions showed a consistent, 1alpha,25(OH)2D3-dependent association with VDR and RXR over a time period of 240 min. Combined in silico/in vitro screening identified in each of these promoter regions a VDRE and reporter gene assays confirmed their functionality. Moreover, re-ChIP assays monitored simultaneous association of VDR with RXR, coactivator, mediator and RNA polymerase II proteins on these regions. Since cyclin C protein is associated with those mediator complexes that display transcriptional repressive properties, this study contributes to the understanding of the downregulation of a number of secondary 1alpha,25(OH)2D3-responding genes. [less ▲]

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See detailTime and Aging--Mechanisms and Meanings
Wollscheid-Lengeling, Evi UL

in Science (2005), 2005(15),

A recent European Molecular Biology Laboratory Conference on Science and Society entitled "Time & Aging--Mechanisms & Meanings" fascinated scientists from different research areas as well as nonscientists ... [more ▼]

A recent European Molecular Biology Laboratory Conference on Science and Society entitled "Time & Aging--Mechanisms & Meanings" fascinated scientists from different research areas as well as nonscientists. Topics discussed included not only the biological aging process but also the psychological effects of aging and social influences that affect this process. [less ▲]

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See detailSorting multiattribute alternatives: The TOMASO method
Marichal, Jean-Luc UL; Meyer, Patrick; Roubens, Marc

in Computers and Operations Research (2005), 32(4), 861-877

We analyze a recently proposed ordinal sorting procedure (Tomaso) for the assignment of alternatives to graded classes and we present a freeware constructed from this procedure. We illustrate it by two ... [more ▼]

We analyze a recently proposed ordinal sorting procedure (Tomaso) for the assignment of alternatives to graded classes and we present a freeware constructed from this procedure. We illustrate it by two examples, and do some testing in order to show its usefulness. [less ▲]

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See detailA framework for computational and experimental methods: identifying dimerization residues in CCR chemokine receptors.
de Juan, David; Mellado, Mario; Rodriguez-Frade, Jose Miguel et al

in Bioinformatics (2005), 21 Suppl 2

Solving relevant biological problems requires answering complex questions. Addressing such questions traditionally implied the design of time-consuming experimental procedures which most of the time are ... [more ▼]

Solving relevant biological problems requires answering complex questions. Addressing such questions traditionally implied the design of time-consuming experimental procedures which most of the time are not accessible to average-sized laboratories. The current trend is to move towards a multidisciplinary approach integrating both theoretical knowledge and experimental work. This combination creates a powerful tool for shedding light on biological problems. To illustrate this concept, we present here a descriptive example of where computational methods were shown to be a key aspect in detecting crucial players in an important biological problem: the dimerization of chemokine receptors. Using evolutionary based sequence analysis in combination with structural predictions two CCR5 residues were selected as important for dimerization and further validated experimentally. The experimental validation of computational procedures demonstrated here provides a wealth of valuable information not obtainable by any of the individual approaches alone. [less ▲]

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See detailRechenbeispiel zum Statischen Nachweis von Verbundträgern mit verformbaren, teiltragfähigen Verbundanschlüssen
Jost, Markus; Odenbreit, Christoph UL

in Stahlbau (2005), 74(2), 134--141

Im Artikel „Zur Berücksichtigung von verformbaren, teiltragfähigen Verbundanschlüssen bei der Berechnung von Verbundträgern“ wurde ein Modell vorgestellt, welches es ermöglicht, aus versuchsgestützten ... [more ▼]

Im Artikel „Zur Berücksichtigung von verformbaren, teiltragfähigen Verbundanschlüssen bei der Berechnung von Verbundträgern“ wurde ein Modell vorgestellt, welches es ermöglicht, aus versuchsgestützten Daten eine bilineare Anschlusskurve für Verbundanschlüsse mit einer biegeweichen, teiltragfähigen Charakteristik zu ermitteln... [less ▲]

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See detailStrategien beim selbstgesteuerten Bewegungslernen: Ergebnisse zur Validität und Reliabilität eines neuen Fragebogens
Bund, Andreas UL; Wiemeyer, Josef

in Zeitschrift für Sportpsychologie (2005), 12(1), 22-34

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See detailVon der wundersamen Bildungsvermehrung durch Ressourcenverknappung
Mein, Georg UL

in kultuRRevolution (2005), 49

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See detailUncertainty of absolute gravity measurements
Van Camp, Michel; Williams, Simon D. P.; Francis, Olivier UL

in Journal of Geophysical Research (2005), 110(B05406), 1-9

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See detailMichel Chion, Un art sonore, le cinéma, 2003
Tore, Gian Maria UL

in Nouveaux Actes Sémiotiques (2005), (98-100), 56-62

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See detailQuelle Europe est née au Moyen Age?
Pauly, Michel UL

in Francia (2005), 32(1), 157-165

Compte rendu critique du livre de Jacques Le Goff, L'Europe est-elle née au Moyen Age?

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See detailWedge-shaped layers from porous silicon: the basics of laterally graded interference filters
Bohn, H. G.; Marso, Michel UL

in Physica Status Solidi A. Applied Research (2005), 202(8), 1437-1442

The process of making laterally graded interference filters has been reanalyzed. A simple and consistent picture arises if one applies a constant electric field perpendicular to the etch current instead ... [more ▼]

The process of making laterally graded interference filters has been reanalyzed. A simple and consistent picture arises if one applies a constant electric field perpendicular to the etch current instead of a constant current. The system is quantitatively modeled by means of a pure ohmic equivalent circuit model. [less ▲]

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See detailMonte Carlo study of hard pentagons
Schilling, Tanja UL; Pronk, S.; Mulder, B. et al

in Physical Review. E ,Statistical, Nonlinear, and Soft Matter Physics (2005), 71(3),

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See detailForcing of Polar Motion in the Chandler Frequency Band: A Contribution to Understanding Interannual Climate Variations
Plag, H.-P.; Chao, B. F.; Gross, R. S. et al

in Cahiers du Centre Européen de Géodynamique et de Séismologie (2005), 24

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See detailHierarchisches Selbstinteresse und Fremdenfeindlichkeit bei Jugendlichen. Gruppendynamik
Hadjar, Andreas UL

in Gruppendynamik (2005), 36(1), 103-126

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See detailComputational methods for the design of effective therapies against drug resistant HIV strains
Beerenwinkel, N.; Sing, T.; Lengauer, T. et al

in Bioinformatics (2005), 21(21), 3943-50

Summary: The development of drug resistance is a major obstacle to successful treatment of HIV infection. The extraordinary replication dynamics of HIV facilitates its escape from selective pressure ... [more ▼]

Summary: The development of drug resistance is a major obstacle to successful treatment of HIV infection. The extraordinary replication dynamics of HIV facilitates its escape from selective pressure exerted by the human immune system and by combination drug therapy. We have developed several computational methods whose combined use can support the design of optimal antiretroviral therapies based on viral genomic data. [less ▲]

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See detailLoss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease.
Strauss, Karsten M.; Martins, Luisa UL; Plun-Favreau, Helene et al

in Human molecular genetics (2005), 14(15), 2099-111

Recently targeted disruption of Omi/HtrA2 has been found to cause neurodegeneration and a parkinsonian phenotype in mice. Using a candidate gene approach, we performed a mutation screening of the Omi ... [more ▼]

Recently targeted disruption of Omi/HtrA2 has been found to cause neurodegeneration and a parkinsonian phenotype in mice. Using a candidate gene approach, we performed a mutation screening of the Omi/HtrA2 gene in German Parkinson's disease (PD) patients. In four patients, we identified a novel heterozygous G399S mutation, which was absent in healthy controls. Moreover, we identified a novel A141S polymorphism that was associated with PD (P<0.05). Both mutations resulted in defective activation of the protease activity of Omi/HtrA2. Immunohistochemistry and functional analysis in stably transfected cells revealed that S399 mutant Omi/HtrA2 and to a lesser extent, the risk allele of the A141S polymorphism induced mitochondrial dysfunction associated with altered mitochondrial morphology. Cells overexpressing S399 mutant Omi/HtrA2 were more susceptible to stress-induced cell death than wild-type. On the basis of functional genomics, our results provide a novel link between mitochondrial dysfunction and neurodegeneration in PD. [less ▲]

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See detailSubversionen der Erinnerung im postdramatischen Theater. Heiner Müller - Elfriede Jelinek - Rainald Goetz
Heimböckel, Dieter UL

in Der Deutschunterricht: Beiträge zu seiner Praxis und wissenschaftlichen Grundlegung (2005), 57(6), 46-53

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See detailL'instrumentalisation de l'histoire prise en flagrant délit : les discours sur l'héritage européen
Margue, Michel UL; Scuto, Denis UL

in Hemecht : Zeitschrift für Luxemburger Geschichte = Revue d'Histoire Luxembourgeoise (2005), 58

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See detailLa regulation américaine des agences de notation
Conac, Pierre-Henri UL

in Risques : les cahiers de l'assurance (2005), (61), 55-55

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See detailL'autorité des marchés financiers (AMF)
Conac, Pierre-Henri UL

in Etude du Dictionnaire Juridique Bourse et Produits Financiers (2005)

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See detailBeyond annotation transfer by homology: novel protein-function prediction methods to assist drug discovery
Ofran, Y.; Punta, M.; Schneider, Reinhard UL et al

in Drug Discovery Today (2005), 10(21), 1475-1482

Every entirely sequenced genome reveals 100s to 1000s of protein sequences for which the only annotation available is 'hypothetical protein'. Thus, in the human genome and in the genomes of pathogenic ... [more ▼]

Every entirely sequenced genome reveals 100s to 1000s of protein sequences for which the only annotation available is 'hypothetical protein'. Thus, in the human genome and in the genomes of pathogenic agents there could be 1000s of potential, unexplored drug targets. Computational prediction of protein function can play a role in studying these targets. We shall review the challenges, research approaches and recently developed tools in the field of computational function-prediction and we will discuss the ways these issues can change the process of drug discovery. [less ▲]

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See detailUmberto Eco: Die geheimnisvolle Flamme der Königin Loana. Ein Buchtipp.
Küpper, Achim UL

in http ://www.arte-tv.com (2005)

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See detailMultiple levels of letter representation in written spelling: evidence from a single case of dysgraphia with multiple deficits.
de Partz, Marie-Pierre; Lochy, Aliette UL; Pillon, Agnesa

in Behavioural neurology (2005), 16(2-3), 119-44

In this paper, we report a detailed analysis of the impaired performance of a dysgraphic individual, AD, who produced similar rates of letter-level errors in written spelling, oral spelling, and typing ... [more ▼]

In this paper, we report a detailed analysis of the impaired performance of a dysgraphic individual, AD, who produced similar rates of letter-level errors in written spelling, oral spelling, and typing. We found that the distribution of various letter error types displayed a distinct pattern in written spelling on the one hand and in oral spelling and typing on the other. In particular, noncontextual letter substitution errors (i.e., errors in which the erroneous letter that replaces the target letter does not occur elsewhere within the word) were virtually absent in oral spelling and typing and mainly found in written spelling. In contrast, letter deletion errors and multiple-letter errors were typically found in oral spelling and very exceptional in written spelling. Only contextual letter substitution errors (i.e., errors in which the erroneous letter that replaces the target letter is identical to a letter occurring earlier or later in the word) were found in similar proportions in the three tasks. We argue that these contrasting patterns of letter error distribution result from damage to two distinct levels of letter representation and processing within the spelling system, namely, the amodal graphemic representation held in the graphemic buffer and the letter form representation computed by subsequent writing-specific processes. Then, we examined the relationship between error and target in the letter substitution errors produced in written and oral spelling and found evidence that distinct types of letter representation are processed at each of the hypothetized levels of damage: symbolic letter representation at the graphemic level and representation of the component graphic strokes at the letter form processing level. [less ▲]

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See detailDe nouvelles opportunités pour les fusions transeuropéennes de banques
Prüm, André UL

in Revue de Droit Bancaire et Financier (2005), (3), 3

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See detailBook review of : P.A. Heuser, Jean Matal. Humanistischer Jurist und europäischer Friedensdenker (um 1517-1597), 2003
Weis, Monique UL

in Francia: Forschungen zur Westeuropäischen Geschichte. 3, 19./20. Jahrhundert (2005), 32(2), 239-240

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See detailActin-filament cross-linking protein T-plastin increases Arp2/3-mediated actin-based movement
Giganti, A.; Plastino, J.; Janji, B. et al

in Journal of Cell Science (2005), 118(6), 1255-1265

Increasing evidence suggests that actin cross-linking or bundling proteins might not only structure the cortical actin cytoskeleton but also control actin dynamics. Here, we analyse the effects of T ... [more ▼]

Increasing evidence suggests that actin cross-linking or bundling proteins might not only structure the cortical actin cytoskeleton but also control actin dynamics. Here, we analyse the effects of T-plastin/T-fimbrin, a representative member of an important actin-filament cross-linking protein by combining a quantitative biomimetic motility assay with biochemical and cell-based approaches. Beads coated with the VCA domain of the Wiskott/Aldrich-syndrome protein (WASP) recruit the actin-nucleating Arp2/3 complex, polymerize actin at their surface and undergo movement when placed in cell-free extracts. T-Plastin increased the velocity of VCA beads 1.5 times, stabilized actin comets and concomitantly displaced cofilin, an actin-depolymerizing protein. T-Plastin also decreased the F-actin disassembly rate and inhibited cofilin-mediated depolymerization of actin filaments in vitro. Importantly, a bundling-incompetent variant comprising the first actin-binding domain (ABD1) had similar effects. In cells, this domain induced the formation of long actin cables to which other actin-regulating proteins were recruited. Altogether, these results favor a mechanism in which binding of ABD1 controls actin turnover independently of cross-link formation. In vivo, this activity might contribute to the assembly and maintenance of the actin cytoskeleton of plasma-membrane protrusions. [less ▲]

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See detailDie Lokalisation des Neurokinin 1-Rezeptors im Hüftgelenk von Patienten mit schmerzhafter Osteoarthrose.
Saxler, Guido; Löer, Franz; von Knoch, Marius et al

in Zeitschrift für Orthopadie und Ihre Grenzgebiete (2005), 143

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See detailLe pouvoir de transaction de la Securities and Exchange Commission (SEC)
Conac, Pierre-Henri UL

in Bulletin Joly Bourse (2005)

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See detailReview of M. Robson and P. Stockwell. Language in Theory
Weber, Jean-Jacques UL

in BELL. Belgian Essays on Language and Literature (2005), 3

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See detailGrowth and properties of GaN and AlN layers on silver substrates
Mikulics, Martin; Kočan, Martin; Rizzi, Angela et al

in Applied Physics Letters (2005), 87

We report on the preparation and properties of GaN and AlN layers grown by molecular-beam epitaxy on silver metal substrates. X-ray diffraction rocking curves show polycrystalline character of GaN with ... [more ▼]

We report on the preparation and properties of GaN and AlN layers grown by molecular-beam epitaxy on silver metal substrates. X-ray diffraction rocking curves show polycrystalline character of GaN with high preferential GaN 11-22 orientation. An intermetallic phase of Ga3Ag is found at the GaN/Ag interface. On the other hand, AlN layers exhibit a monocrystalline structure with a growth direction of 0002 . Schottky diodes prepared on GaN layers show good rectifying behavior and relatively low leakage current 10−3 A/cm2 . These results indicate that the III-nitride growth on metallic substrates might be used for low-cost and large-area electronic and photonic devices. [less ▲]

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See detailA cross-sectional international survey of continuous subcutaneous insulin infusion (CSII) in 377 children and adolescents with type 1 diabetes mellitus from 10 countries
Danne, T.; Battelino, T.; Kordonouri, O. et al

in Pediatric Diabetes (2005), 6

OBJECTIVE: To document current practices using continuous subcutaneous insulin infusion (CSII) by downloading electronically the 90-d pump data held within the pump memory and relating that to clinical ... [more ▼]

OBJECTIVE: To document current practices using continuous subcutaneous insulin infusion (CSII) by downloading electronically the 90-d pump data held within the pump memory and relating that to clinical data from children and adolescents in different pediatric diabetes centers from Europe and Israel. METHODS: Data of patients (1-18 yr) treated with CSII in 23 centers from nine European countries and Israel were recorded with the encapture software (PEC International, Frankfurt, Germany). The number of patients who participated was 377 (48% female; mean diabetes duration +/- SD: 6.8 +/- 3.7 yr; age: 12.9 +/- 3.8 yr, preschool n = 33; prepubertal n = 95; adolescent n = 249; CSII duration: 1.6 +/- 1.2 yr; local HbA1c: 8.1 +/- 1.2%). RESULTS: The total insulin dose was lower than previously reported for injection therapy (0.79 +/- 0.20 U/kg/d). Covariance coefficient of daily total insulin was high in all age groups (adolescents 19 +/- 9%, prepubertal 18 +/- 8 and preschool 17 +/- 8). The distribution of basal insulin infusion rates over 24 hr (48 +/- 12% of total dose) varied significantly between centers and age groups. The number of boluses per day (7 +/- 3) was not significantly different between the age groups (average daily bolus amount: 0.42 +/- 0.16 U/kg). The rate of severe hypoglycemia (coma/convulsions) was 12.4 episodes per 100 patient-years and the number of diabetes-related hospital days was 124 per 100 patient-years. DISCUSSION: Pediatric CSII patients show a high variability in their insulin therapy. This relates both to age-dependent differences in the distribution of basal insulin as to the age-independent day-to-day variation in prandial insulin. [less ▲]

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See detailGeneration of frustrated liquid crystal phases by mixing an achiral n–smc mesogen with an antiferroelectric chiral smectic liquid crystal
Lagerwall, Jan UL; Giesselmann, Frank; Selbmann, Christine et al

in Journal of Chemical Physics (2005), 122(14), 144906

By mixing the achiral liquid crystal HOAB, exhibiting a nematic (N)-smectic-C (SmC) mesophase sequence, with the chiral antiferroelectric liquid crystal (AFLC) (S,S)-M7BBM7, forming the antiferroelectric ... [more ▼]

By mixing the achiral liquid crystal HOAB, exhibiting a nematic (N)-smectic-C (SmC) mesophase sequence, with the chiral antiferroelectric liquid crystal (AFLC) (S,S)-M7BBM7, forming the antiferroelectric SmCa phase, at least seven different mesophases have been induced which neither component forms on its own: a twist-grain-boundary (TGB) phase, two or three blue phases, the untilted SmA phase, as well as all three chiral smectic-C-type ``subphases,'' SmCalpha, SmCbeta, and SmCgamma. The nature of the induced phases and the transitions between them were determined by means of optical and electro-optical investigations, dielectric spectroscopy, and differential scanning calorimetry. The induced phases can to a large extent be understood as a result of frustration, TGB at the border between nematic and smectic, the subphases between syn and anticlinic tilted smectic organization. X ray scattering experiments reveal that the smectic layer spacing as well as the degree of smectic order is relatively constant in the whole mixture composition range in which AFLC behavior prevails, whereas both these parameters rapidly decrease as the amount of HOAB is increased to such an extent that no other smectic-C-type phase than SmC/SmC exists. By tailoring the composition we are able to produce liquid crystal mixtures exhibiting unusual phase sequences, e.g., with a direct isotropic-SmCa transition or a temperature range of the SmCbeta subphase of about 50 K. (C) 2005 American Institute of Physics. [less ▲]

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See detailOnline Forums and Deliberative Democracy
Janssen, Davy; Kies, Raphaël UL

in Acta Politica (2005), 40

The Internet is rapidly becoming a part of the everyday lives of a majority of people in the Western world. People perform various activities on the Internet and one of them is discussing politics and ... [more ▼]

The Internet is rapidly becoming a part of the everyday lives of a majority of people in the Western world. People perform various activities on the Internet and one of them is discussing politics and society in so-called online forums. In this article, we present an overview of some of the empirical research that evaluates the quality of political conversations in online forums. In the first section, we distinguish research on Usenet groups, web-based political forums and e-consultation forums, and discuss some its findings. In the second section, we elaborate three original categories of variables that attempt to explain differences observed in the quality of deliberation. The third, more extensive section deals with methodological issues. It discusses the operationalisation of deliberative quality and the application of a set of criteria for the idealized public sphere to online conversations. In the conclusion, we present some objections to the previous research and offer some ideas for a more comprehensive approach to online forum analysis. [less ▲]

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See detailFish consumption and coronary heart disease: A review of data on the dose-response relationship
König, Ariane UL; Cohen, J. T.; Bouzan, C. et al

in American Journal of Preventive Medicine (2005), 29(4), 335-346

Although a rich source of n-3 polyunsaturated fatty acids (PUFAs) that may confer multiple health benefits, some fish contain methyl mercury (MeHg), which may harm the developing fetus. U.S. government ... [more ▼]

Although a rich source of n-3 polyunsaturated fatty acids (PUFAs) that may confer multiple health benefits, some fish contain methyl mercury (MeHg), which may harm the developing fetus. U.S. government recommendations for women of childbearing age are to modify consumption of high-MeHg fish to reduce MeHg exposure, while recommendations encourage fishconsumption among the general population because of the nutritional benefits. The Harvard Center for Risk Analysis convened an expert panel (see acknowledgments) to quantify the net impact of resulting hypothetical changes in fishconsumption across the population. This paper estimates the impact of fishconsumption on coronaryheartdisease (CHD) mortality and nonfatal myocardial infarction (MI). Other papers quantify stroke risk and the impacts of both prenatal MeHg exposure and maternal intake of n-3 PUFAs on cognitive development. This analysis identified articles in a recent qualitative review appropriate for the development of a dose–response relationship. Studies had to satisfy quality criteria, quantify fish intake, and report the precision of the relative risk estimates. Relative risk results were averaged, weighted proportionately by precision. CHD risks associated with MeHg exposure were reviewed qualitatively because the available literature was judged inadequate for quantitative analysis. Eight studies were identified (29 exposure groups). Our analysis estimated that consuming small quantities of fish is associated with a 17% reduction in CHD mortality risk, with each additional serving per week associated with a further reduction in this risk of 3.9%. Small quantities of fishconsumption were associated with risk reductions in nonfatal MI risk by 27%, but additional fishconsumption conferred no incremental benefits. [less ▲]

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See detailAre STATS arginine-methylated?
Komyod, W.; Bauer, U. M.; Heinrich, P. C. et al

in Journal of Biological Chemistry (2005), 280(23), 21700-5

Transcription factors of the STAT (signal transducer and activator of transcription) family are important in signal transduction of cytokines. They are subject to post-translational modification by ... [more ▼]

Transcription factors of the STAT (signal transducer and activator of transcription) family are important in signal transduction of cytokines. They are subject to post-translational modification by phosphorylation on tyrosine and serine residues. Recent evidence suggested that STATs are methylated on a conserved arginine residue within the N-terminal region. STAT arginine methylation has been described to be important for STAT function and loss of arginine methylation was discussed to be involved in interferon resistance of cancer cells. Here we provide several independent lines of evidence indicating that the issue of arginine methylation of STATs has to be reassessed. First, we show that treatment of melanoma and fibrosarcoma cells with inhibitors used to suppress methylation (N-methyl-2-deoxyadenosine, adenosine, dl-homocysteine) had profound and rapid effects on phosphorylation of STAT1 and STAT3 but also on p38 and Erk signaling cascades which are known to cross-talk with the Jak/STAT pathway. Second, we show that anti-methylarginine antibodies did not precipitate specifically STAT1 or STAT3. Third, we show that mutation of Arg(31) to Lys led to destabilization of STAT1 and STAT3, implicating an important structural role of Arg(31). Finally, purified catalytically active protein arginine methyltransferases (PRMT1, -2, -3, -4, and -6) did not methylate STAT proteins, and cotransfection with PRMT1 did not affect STAT1-controlled reporter gene activity. Taken together, our data suggest the absence of arginine methylation of STAT1 and STAT3. [less ▲]

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See detailDécision de la Cour de cassation, 1ère Civ., 30 juin 2004
Cuniberti, Gilles UL

in Clunet (2005)

Reconnaissance de mesures conservatoires étrangères.

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See detailExpanded metabolic reconstruction of Helicobacter pylori (iIT341 GSM/GPR): an in silico genome-scale characterization of single- and double-deletion mutants.
Thiele, Ines UL; Vo, Thuy D.; Price, Nathan D. et al

in Journal of Bacteriology (2005), 187(16), 5818-30

Helicobacter pylori is a human gastric pathogen infecting almost half of the world population. Herein, we present an updated version of the metabolic reconstruction of H. pylori strain 26695 based on the ... [more ▼]

Helicobacter pylori is a human gastric pathogen infecting almost half of the world population. Herein, we present an updated version of the metabolic reconstruction of H. pylori strain 26695 based on the revised genome annotation and new experimental data. This reconstruction, iIT341 GSM/GPR, represents a detailed review of the current literature about H. pylori as it integrates biochemical and genomic data in a comprehensive framework. In total, it accounts for 341 metabolic genes, 476 intracellular reactions, 78 exchange reactions, and 485 metabolites. Novel features of iIT341 GSM/GPR include (i) gene-protein-reaction associations, (ii) elementally and charge-balanced reactions, (iii) more accurate descriptions of isoprenoid and lipopolysaccharide metabolism, and (iv) quantitative assessments of the supporting data for each reaction. This metabolic reconstruction was used to carry out in silico deletion studies to identify essential and conditionally essential genes in H. pylori. A total of 128 essential and 75 conditionally essential metabolic genes were identified. Predicted growth phenotypes of single knockouts were validated using published experimental data. In addition, in silico double-deletion studies identified a total of 47 synthetic lethal mutants involving 67 different metabolic genes in rich medium. [less ▲]

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See detailDe Brutalisering voorbij. De Eerste Wereldoorlog en politiek geweld in Europa
Majerus, Benoît UL; Vrints, Antoon

in Jaarboek van het Nederlands Instituut voor Oorlogsdocumentatie (2005), (16), 52-74

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See detailLutter contre les facteurs de morbidité liés à la pauvreté. Recommandations de l'OMS
Baumann, Michèle UL

in Pédiatre (Le) (2005), (211), 9-10

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See detailMultiple reasons for an inefficient STAT1 response upon IL-6-type cytokine stimulation
Haan, Serge UL; Keller, J. F.; Behrmann, Iris UL et al

in Cellular Signalling (2005), 17(12), 1542-50

IL-6-type cytokines play an important role during inflammation and the immune response. In addition, they are involved in haematopoiesis, liver and neuronal regeneration, embryonic development and ... [more ▼]

IL-6-type cytokines play an important role during inflammation and the immune response. In addition, they are involved in haematopoiesis, liver and neuronal regeneration, embryonic development and fertility. We found that IL-6-type cytokine stimulation of cell lines and primary human macrophages results in a different distribution of the DNA-binding competent STAT dimer species in the cytosol and nucleus as demonstrated by electrophoretic mobility shift assays. In the absence of detergent, STAT3/STAT3, STAT1/STAT3 were the predominant species in the cytoplasm while STAT3/STAT3 was predominant in the nucleus. However, in detergent containing total cellular lysates and nuclear fractions prepared with detergent containing buffers, the STAT1/STAT1 homodimer was as prominent or even more prominent than STAT3/STAT3 and STAT1/STAT3. We were interested in the cause of this discrepancy since STAT1-regulated genes have not been described to be expressed upon IL-6-type cytokine stimulation. In addition to the more transient STAT1 activation, IL-6-type cytokines such as IL-6 and OSM lead to a much less efficient STAT1 activation compared to the potent STAT1 activators IFNgamma and IFNalpha. Studies with STAT1-deficient cells revealed that STAT1 activation does not seem to be an important competitive process to STAT3 activation arguing again for a very inefficient STAT1 activation upon IL-6-type cytokine stimulation. We also describe that pY-STAT3 is much more efficiently shuttled into the nucleus than pY-STAT1. [less ▲]

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See detailLe texte en question
Tore, Gian Maria UL

in E/C (revue en ligne de l’Associazione Italiana di Studi Semiotici) (2005)

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See detailInternational Humanitarian Law, War Criminality and Child Recruitment
Happold, Matthew UL

in Leiden Journal of International Law (2005), 18

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See detailAlternative binding modes of proline-rich peptides binding to the GYF domain
Gu, Wei UL; Kofler, M.; Antes, I. et al

in Biochemistry (2005), 44(17), 6404-6415

Recognition of proline-rich sequences plays an important role for the assembly of multiprotein complexes during the course of eukaryotic signal transduction and is mediated by a set of protein folds that ... [more ▼]

Recognition of proline-rich sequences plays an important role for the assembly of multiprotein complexes during the course of eukaryotic signal transduction and is mediated by a set of protein folds that share characteristic features. The GYF (glycine-tyrosine-phenylalanine) domain is known as a member of the superfamily of recognition domains for proline-rich sequences. Recent studies on the complexation of the CD2BP2-GYF domain with CD2 peptides showed that the peptide adopts an extended conformation and forms a polyproline type-II helix involving residues Pro4-Pro7 [Freund et al. (2002) EMBO J. 21, 5985-5995]. R/K/GxxPPGxR/K is the key signature for the peptides that bind to the GYF domain [Kofler et at. (2004) J. Biol. Chem. 279, 28292-28297]. In our combined theoretical and experimental study, we show that the peptides adopt a polyproline 11 helical conformation in the unbound form as well as in the complex. From molecular dynamics simulations, we identify a novel binding mode for the G8W mutant and the wild-type peptide (shifted by one proline in register). In contrast, the conformation of the peptide mutant H9M remains close to the experimentally derived wild-type GYF-peptide complex. Possible functional implications of this altered conformation of the bound ligand are discussed in the light of our experimental and theoretical results. [less ▲]

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See detailHalle-Neustadt - Ein Stadtteil mit Zukunft?
Steigleider, Sandra; Willems, Helmut UL

in Neustädter Nachrichten (2005)

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See detailInfection and Corruption: Cooks and Kitchens in Eighteenth-Century France
Takats, Sean UL; Edwards, Kathryn; Harrison, Carol

in Proceedings of the Western Society for French History (2005), 33

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See detailGlobal geometric deformations of current algebras as Krichever-Novikov type algebras
Fialowski, Alice; Schlichenmaier, Martin UL

in Communications in Mathematical Physics (2005), 260(3), 579-612

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See detailChanges in diabetes prevalence and treatment in the last ten years in Luxembourg. A lesson from the United Kingdom prospective diabetes study?
Perquin, M.; Michel, G. H.; De Beaufort, Carine UL et al

in Diabetes and Metabolism (2005), 31(5), 499-502

Objectives: The aims of the study were to estimate the prevalence of diabetes in Luxembourg in 2002, to compare it to the prevalence reported in 1991 and to evaluate if prescription attitudes have changed ... [more ▼]

Objectives: The aims of the study were to estimate the prevalence of diabetes in Luxembourg in 2002, to compare it to the prevalence reported in 1991 and to evaluate if prescription attitudes have changed since 1991. Methods: The prevalence of diabetes was estimated using the drug sales data. The key parameters, total amount of antidiabetic drugs sold in one year and the average daily dose or Prescribed Daily Dose (PDD), have been obtained from the National Social Security Organization and by a standardized questionnaire sent to all general practitioners and all internists and endocrinologists of the country. Results: The PDD was calculated on 2, 402 questionnaires on individual diabetic patients. By this means, the proportion of patients only treated with appropriate diet could also be obtained. Compared to 1991, the total amount of antidiabetic drugs showed a four-fold increase in metformine tablet prescriptions. A high percentage of combined treatments was found. The prevalence of diabetes in Luxembourg was found to be 3.05% of the total population. Conclusions: Compared to the status in 1991, prevalence of diabetes increased by 63%, which seems mainly due to type 2 diabetic patients as orally-treated diabetic patients almost doubled (2.11% vs 1.16%). A substantial change in prescriptions for diabetes has occurred, suggesting a positive influence of studies like the United Kingdom Prospective Diabetes Study (UKPDS). © 2005 Masson, all rights reserved. [less ▲]

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See detailOxidative stress activates MMP-2 in cultured human coronary smooth muscle cells
Valentin, F.; Bueb, Jean-Luc UL; Kieffer, P. et al

in Fundamental and Clinical Pharmacology (2005), 19(6), 661-7

Oxidative stress is a cardinal feature of the inflammatory process and is involved in various pathologies including atherosclerosis. One of the important mechanisms in which oxidative stress may play a ... [more ▼]

Oxidative stress is a cardinal feature of the inflammatory process and is involved in various pathologies including atherosclerosis. One of the important mechanisms in which oxidative stress may play a role is activation of matrix metalloproteinases such as MMP-2, which are involved in plaque destabilization. We investigated the mechanisms by which oxidative stress induces MMP-2 activation in cultured human coronary artery smooth muscle cells. Using zymography and Western blot analysis, we showed that oxidized low-density lipoproteins activate MMP-2 through up-regulation of the expression and activation of a membrane-type 1 matrix metalloproteinase (MT1-MMP). A second mechanism of MMP-2 activation involves oxidative radicals generated by the xanthine/xanthine oxidase complex (X/Xo). Research on these two mechanisms of MMP activation could lead to the elaboration of new vascular therapies for the treatment of atheroma based on interruption of a specific oxidative stress pathway. [less ▲]

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See detailFractal river networks of Southern Africa
Stankiewicz, Jacek UL; de Wit, M. J.

in South African Journal of Geology (2005), 108(3), 333-344

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See detailReden wie Deutsche in Frankreich. Kultur prägt Kommunikation
Wille, Christian UL

in Interkulturell und global : Forum für interkulturelle Kommunikation, Erziehung, Bildung und globales Lernen (2005), (3/4), 219-222

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See detailDipole-field-induced spin disorder in a nanocomposite soft magnet
Michels, Andreas UL; Vecchini, C.; Moze, O. et al

in Europhysics Letters (2005), 72(2), 249-255

We report on a study of a magnetic nanocomposite of the Nanoperm type (Fe89Zr7B3Cu1) by magnetic small-angle neutron scattering (SANS). The understanding of the magnetic microstructure of these materials ... [more ▼]

We report on a study of a magnetic nanocomposite of the Nanoperm type (Fe89Zr7B3Cu1) by magnetic small-angle neutron scattering (SANS). The understanding of the magnetic microstructure of these materials leaves much to be desired since we lack techniques capable of resolving the spin structure in the bulk with nanoscale resolution. Here, we present an analysis of the SANS signal by which one cannot only characterise the nanoscale structure of the spin system, but which allows to identify origin and structure of the perturbing field. In Nanoperm, an unusual angular anisotropy of the scattering suggests that the local spin misalignment decorates, as the most important perturbing field, dipole stray fields around the crystalline phase of the composite. [less ▲]

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See detailCondotta antisindacale della P.A., violazione di accordo di concertazione e credibilità del sindacato
Ratti, Luca UL

in Il Lavoro nelle Pubbliche Amministrazioni (2005)

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See detailTesting convex hypotheses on the mean of a Gaussian vector. Application to testing qualitative hypotheses on a regression function
Baraud, Yannick UL; Huet, Sylvie; Laurent, Béatrice

in Annals of Statistics (2005), 33(1), 214--257

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See detailLes instruments de fonds propres des coopératives - vingt ans d'innovation législative
Hiez, David UL

in Revue Internationale de l'Economie Sociale : Recma, Revue des Etudes Coopératives, Mutualistes et Associatives (2005), (295), 20-37

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See detailL’Edict et Ordonnance sur le fait de la conduicte des gens de guerre et discipline militaire du 27 mai 1596 : une source normative pour l’histoire sociale des armées modernes
Weis, Monique UL

in Bulletin de la Commission Royale Pour la Publication des Anciennes Lois et Ordonnances de Belgique (2005)

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See detailChiral smectic C subphases induced by mixing a bistereogenic antiferroelectric liquid crystal with a non-chiral liquid crystal
Lagerwall, Jan UL; Giesselmann, Frank; Rauch, Sebastian et al

in Ferroelectrics (2005), 315

By mixing a bistereogenic antiferroelectric liquid crystal (AFLC) compound, exhibiting only the SmQ and SmCa mesophases, with the achiral N-SmC liquid crystal HOAB we could induce all three AFLC SmC-type ... [more ▼]

By mixing a bistereogenic antiferroelectric liquid crystal (AFLC) compound, exhibiting only the SmQ and SmCa mesophases, with the achiral N-SmC liquid crystal HOAB we could induce all three AFLC SmC-type subphases, SmCalpha, SmCbeta and SmCgamma. This seems to be in contradiction with two recent postulations regarding the subphase stability, one of which suggests that the subphases appear as a result of strong chiral interactions, the other that these phases require high smectic order something one would generally not expect in mixtures. We have studied the helical pitch, optical tilt angle, spontaneous polarization and the x-ray diffraction due to the smectic layering, as a function of mixing ratio in order to better understand the relation between phase sequence and mixture composition. The smectic layer spacing shows a strongly non-linear behavior suggesting that the basic structure of the pure AFLC substance is retained up to a HOAB content of about 75\%. [less ▲]

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See detailLa peur du grand complot catholique. La diplomatie espagnole face aux soupçons des protestants allemands (1560-1570)
Weis, Monique UL

in Francia: Forschungen zur Westeuropäischen Geschichte. 3, 19./20. Jahrhundert (2005), 32(2), 15-30

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See detailQuali sono gli obiettivi educativi privilegiati dalle famiglie ?
Poncelet, Débora UL

in Psicologia Dell’ Educazione E Della Formazione (2005), 7(2), 155-169

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See detailKörperbild, Diätverhalten und körperliche Aktivität bei 9-10 jährigen Kindern
Vögele, Claus UL; Woodward, Heidi

in Kindheit und Entwicklung (2005), 14

The aim of the present study was to investigate body dissatisfaction and eating attitudes and the moderating role of gender, parental influences, body-mass index (BMI), and physical activity in 9 ± 10 ... [more ▼]

The aim of the present study was to investigate body dissatisfaction and eating attitudes and the moderating role of gender, parental influences, body-mass index (BMI), and physical activity in 9 ± 10-year-old children. Sixty-eight 9 ± 10-year-old children (36 boys, 32 girls) were asked to indicate their perceived and ideal body size using the figure drawing scale of Childress et al. (1993). Physical activity levels were assessed with a diary method over 7 consecutive days. Questionnaires were used to collect information on children's eating habits and children's perception of parental weight, parental attitudes towards body size, and eating habits. Children's weight and height were measured and the BMI calculated. 44 % of boys and 34 % of girls wanted to be thinner than they perceived themselves to be. Multiple regression analyses indicated that this desire was predicted by children's BMI, perceived overweight of mother, and eating patterns indicating restraint eating style. Given that only 13 % were overweight, the percentage of children wanting to be thinner is of concern. The current results indicate that there may be an increasing trend for a thinner body ideal in boys compared to previous reports. [less ▲]

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See detailWalter Herzog, Zeitgemäße Erziehung. Die Konstruktion pädagogischer Wirklichkeit.Weilerswist: Velbrück 2002
Priem, Karin UL

in Vierteljahresschrift für wissenschaftliche Pädagogik (2005), 81

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See detailEichendorff mit Kleist. "Das Schloß Dürande" als Dichtung umgestürzter Ordnung
Heimböckel, Dieter UL

in Aurora. Jahrbuch der Eichendorff-Gesellschaft (2005), 65

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See detailRaman spectra of BN nanotubes: Ab initio and bond-polarizability model calculations
Wirtz, Ludger UL; Lazzeri, M.; Mauri, F. et al

in Physical Review. B, Condensed Matter and Materials Physics (2005), 71(24),

We present ab initio calculations of the nonresonant Raman spectra of zigzag and armchair BN nanotubes. In comparison, we implement a generalized bond-polarizability model where the parameters are ... [more ▼]

We present ab initio calculations of the nonresonant Raman spectra of zigzag and armchair BN nanotubes. In comparison, we implement a generalized bond-polarizability model where the parameters are extracted from first-principles calculations of the polarizability tensor of a BN sheet. For light polarization along the tube axis, the agreement between model and ab initio spectra is almost perfect. For perpendicular polarization, depolarization effects have to be included in the model in order to reproduce the ab initio Raman intensities. [less ▲]

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See detailMathis Leibetseder: Die Kavalierstour. Adelige Erziehungsreisen im 17. und 18. Jahrhundert
Tröhler, Daniel UL

in Zeitschrift für Pädagogik (2005), 51

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See detailFine Disintegration of the Left Regular Representation
Ludwig, Jean; Molitor-Braun, Carine UL

in Journal of Algebra and Its Applications (2005), 4(6), 683-706

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See detailEffect of gravitational consistency and mass conservation on seasonal surface mass loading models
Clarke, Peter J.; Lavallée, David A.; Blewitt, Geoffrey et al

in Geophysical Research Letters (2005), 32(L08306), 1-5

Increasingly, models of surface mass loads are used either to correct geodetic time coordinates by removing seasonal and other ‘‘noise’’, or for comparison with other geodetic parameters. However, models ... [more ▼]

Increasingly, models of surface mass loads are used either to correct geodetic time coordinates by removing seasonal and other ‘‘noise’’, or for comparison with other geodetic parameters. However, models of surface loading obtained by simply combining the mass redistribution due to individual phenomena will not in general be self- consistent, in that (i) the implied global water budget will not be mass-conserving, and (ii) the modelled sea level will not be an equipotential surface of Earth’s total gravity field. We force closure of the global water budget by allowing the ‘‘passive’’ ocean to change in mass. This medium-term passive ocean response will not be a uniform change in non- steric ocean surface height, but must necessarily be spatially variable to keep the ‘‘passive’’ ocean surface on an equipotential. Using existing load models, we demonstrate the effects of our consistency theory. Geocenter motion is amplified significantly, by up to 43%. [less ▲]

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See detailAufgeklärte Pädagogen. Die Erziehungswissenschaft und das geistige Erbe Pierre Bourdieus
Neumann, Sascha UL

in Vierteljahresschrift für wissenschaftliche Pädagogik (2005), 81(3), 345-351

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See detailComplementing computationally predicted regulatory sites in Tractor_DB using a pattern matching approach.
Guia, Marylens Hernandez; Perez, Abel Gonzalez; Espinosa Angarica, Vladimir UL et al

in In silico biology (2005), 5(2), 209-19

Prokaryotic genomes annotation has focused on genes location and function. The lack of regulatory information has limited the knowledge on cellular transcriptional regulatory networks. However, as more ... [more ▼]

Prokaryotic genomes annotation has focused on genes location and function. The lack of regulatory information has limited the knowledge on cellular transcriptional regulatory networks. However, as more phylogenetically close genomes are sequenced and annotated, the implementation of phylogenetic footprinting strategies for the recognition of regulators and their regulons becomes more important. In this paper we describe a comparative genomics approach to the prediction of new gamma-proteobacterial regulon members. We take advantage of the phylogenetic proximity of Escherichia coli and other 16 organisms of this subdivision and the intensive search of the space sequence provided by a pattern-matching strategy. Using this approach we complement predictions of regulatory sites made using statistical models currently stored in Tractor_DB, and increase the number of transcriptional regulators with predicted binding sites up to 86. All these computational predictions may be reached at Tractor_DB (www.bioinfo.cu/Tractor_DB, www.tractor.lncc.br, www.ccg.unam.mx/Computational_Genomics/tractorDB/). We also take a first step in this paper towards the assessment of the conservation of the architecture of the regulatory network in the gamma-proteobacteria through evaluating the conservation of the overall connectivity of the network. [less ▲]

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See detailPrdeicing the failure of disc surgery by a hypofunctional HPA axis: evidence from a prospective study of patients undergoing disc surgery
Geiss, Andrea; Rohleder, Nicolas; Kirschbaum, Clemens et al

in Pain (2005)

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See detailLa politique commerciale commune selon le traité établissant une Constitution pour l’Europe
Neframi, Eleftheria UL

in Revue Trimestrielle de Droit Européen (2005)

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See detailComparative studies of transcriptional regulation mechanisms in a group of eight gamma-proteobacterial genomes.
Espinosa Angarica, Vladimir UL; Gonzalez, Abel D.; Vasconcelos, Ana T. et al

in Journal of molecular biology (2005), 354(1), 184-99

Experimental data on the Escherichia coli transcriptional regulation has enabled the construction of statistical models to predict new regulatory elements within its genome. Far less is known about the ... [more ▼]

Experimental data on the Escherichia coli transcriptional regulation has enabled the construction of statistical models to predict new regulatory elements within its genome. Far less is known about the transcriptional regulatory elements in other gamma-proteobacteria with sequenced genomes, so it is of great interest to conduct comparative genomic studies oriented to extracting biologically relevant information about transcriptional regulation in these less studied organisms using the knowledge from E. coli. In this work, we use the information stored in the TRACTOR_DB database to conduct a comparative study on the mechanisms of transcriptional regulation in eight gamma-proteobacteria and 38 regulons. We assess the conservation of transcription factors binding specificity across all the eight genomes and show a correlation between the conservation of a regulatory site and the structure of the transcription unit it regulates. We also find a marked conservation of site-promoter distances across the eight organisms and a correspondence of the statistical significance of co-occurrence of pairs of transcription factor binding sites in the regulatory regions, which is probably related to a conserved architecture of higher-order regulatory complexes in the organisms studied. The results obtained in this study using the information on transcriptional regulation in E. coli enable us to conclude that not only transcription factor-binding sites are conserved across related species but also several of the transcriptional regulatory mechanisms previously identified in E. coli. [less ▲]

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See detailTRACTOR_DB: a database of regulatory networks in gamma-proteobacterial genomes.
Gonzalez, Abel D.; Espinosa Angarica, Vladimir UL; Vasconcelos, Ana T. et al

in Nucleic acids research (2005), 33(Database issue), 98-102

Experimental data on the Escherichia coli transcriptional regulatory system has been used in the past years to predict new regulatory elements (promoters, transcription factors (TFs), TFs' binding sites ... [more ▼]

Experimental data on the Escherichia coli transcriptional regulatory system has been used in the past years to predict new regulatory elements (promoters, transcription factors (TFs), TFs' binding sites and operons) within its genome. As more genomes of gamma-proteobacteria are being sequenced, the prediction of these elements in a growing number of organisms has become more feasible, as a step towards the study of how different bacteria respond to environmental changes at the level of transcriptional regulation. In this work, we present TRACTOR_DB (TRAnscription FaCTORs' predicted binding sites in prokaryotic genomes), a relational database that contains computational predictions of new members of 74 regulons in 17 gamma-proteobacterial genomes. For these predictions we used a comparative genomics approach regarding which several proof-of-principle articles for large regulons have been published. TRACTOR_DB may be currently accessed at http://www.bioinfo.cu/Tractor_DB, http://www.tractor.lncc.br/ or at http://www.cifn.unam.mx/Computational_Genomics/tractorDB. Contact Email id is tractor@cifn.unam.mx. [less ▲]

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See detailSTAT5 contributes to interferon resistance of melanoma cells
Wellbrock, C.; Weisser, C.; Hassel, J. C. et al

in Current Biology (2005), 15(18), 1629-39

BACKGROUND: Malignant melanoma is a highly aggressive neoplastic disease whose incidence is increasing rapidly. In recent years, the use of interferon alpha (IFNalpha) has become the most established ... [more ▼]

BACKGROUND: Malignant melanoma is a highly aggressive neoplastic disease whose incidence is increasing rapidly. In recent years, the use of interferon alpha (IFNalpha) has become the most established adjuvant immunotherapy for melanoma of advanced stage. IFNalpha is a potent inhibitor of melanoma cell proliferation, and the signal transducer and activator of transcription STAT1 is crucial for its antiproliferative action. Although advanced melanomas clinically resistant to IFNalpha are frequently characterized by inefficient STAT1 signaling, the mechanisms underlying advanced-stage interferon resistance are poorly understood. RESULTS: Here, we demonstrate that IFNalpha activates STAT5 in melanoma cells and that in IFNalpha-resistant cells STAT5 is overexpressed. Significantly, the knockdown of STAT5 in interferon-resistant melanoma cells restored the growth-inhibitory response to IFNalpha. When STAT5 was overexpressed in IFNalpha-sensitive cells, it counteracted interferon-induced growth inhibition. The overexpressed STAT5 diminished IFNalpha-triggered STAT1 activation, most evidently through upregulation of the inhibitor of cytokine-signaling CIS. CONCLUSIONS: Our data demonstrate that overexpression and activation of STAT5 enable melanoma cells to overcome cytokine-mediated antiproliferative signaling. Thus, overexpression of STAT5 can counteract IFNalpha signaling in melanoma cells, and this finally can result in cytokine-resistant and progressively growing tumor cells. These findings have significant implications for the clinical failure of IFNalpha therapy of advanced melanoma because they demonstrate that IFNalpha induces the activation of STAT5 in melanoma cells, and in STAT5-overexpressing cells, this contributes to IFNalpha resistance. [less ▲]

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See detailProperties of Equivalence Scales in Different Countries
Koulovatianos, Christos UL; Schröder, Carsten; Schmidt, Ulrich

in Journal of Economics (2005), 86

Recent studies in high-income industrialized countries have shown that equivalence scales are income-dependent. We investigate whether this dependence also holds in poorer, services oriented countries, by ... [more ▼]

Recent studies in high-income industrialized countries have shown that equivalence scales are income-dependent. We investigate whether this dependence also holds in poorer, services oriented countries, by considering the example of Cyprus. We also examine whether household economies of scale and relative children costs differ. [less ▲]

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See detailCognitive poetics and literary criticism: Types of resolution in the condition-of-England novel
Weber, Jean-Jacques UL

in European Journal of English Studies (2005), 9(2), 131-141

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See detailRegionalprodukte
Hesse, Markus UL

in Erde: Zeitschrift der Gesellschaft für Erdkunde zu Berlin (2005), 136(1), 36-37

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See detailOverdamping by weakly coupled environments
Esposito, Massimiliano UL; Haake, F.

in Physical Review. A (2005), 72(6),

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See detailInterfacial tension of the isotropic-nematic interface in suspensions of soft spherocylinders
Vink, R. L. C.; Schilling, Tanja UL

in Physical Review. E ,Statistical, Nonlinear, and Soft Matter Physics (2005), 71(5),

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See detailSonderpädagogische Fördersysteme im 20. Jahrhundert: Ein deutsch-amerikanischer Vergleich
Powell, Justin J W UL

in Vierteljahresschrift für Heilpädagogik und ihre Nachbargebiete (2005), 74(2), 165-167

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See detailGeotechnical applications and conditions of the observational method
Van Baars, Stefan UL; Vrijling

in Heron (2005), 50(3),

Information observed during construction can be used to optimise the remaining parts of the construction or structure. In this article general conditions are indicated for the implementation of the ... [more ▼]

Information observed during construction can be used to optimise the remaining parts of the construction or structure. In this article general conditions are indicated for the implementation of the Observational Method in geotechnical engineering. The most important condition is that the uncertain field condition (the observational data) must be clear to measure. For example in case of a brittle soil behaviour, there is no clear indicator to show that the load is approaching the maximum resistance. If a project fulfils all general conditions, a financial risk analysis is necessary to find out whether the Observational Method is profitable. The success of implementation varies strongly per geotechnical discipline. In this article a simplified approach for a risk analysis is given and a number of geotechnical cases are discussed for which the Observational Method can lead to a financial profit. Most of these cases are already informally implemented in daily practice. [less ▲]

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See detailZwischen/Räume und Grenzgänge. Einige Überlegungen zu Bildungsprozessen im Medium des Theaterspielens
Karl, Ute UL

in Korrespondenzen. Zeitschrift für Theaterpädagogik (2005), 21(47), 33-41

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