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See detailA correlation for pool entrainment phenomenon
Ouallal, Mohammed UL; Leyer, Stephan UL; Gupta, Sanjeev

in Nuclear Engineering and Design (2021)

The present work aims to study the phenomena of droplet entrainment from water pool in a confined atmosphere, which could be either a consequence of boiling or depressurization. Eventually, these droplets ... [more ▼]

The present work aims to study the phenomena of droplet entrainment from water pool in a confined atmosphere, which could be either a consequence of boiling or depressurization. Eventually, these droplets are entrained by the streaming gas (superficial gas velocity) or settling down due to gravity. The number of correlations developed so far quantify the entrainment based on empirical, semi-empirical and theoretical approaches, but they have been generally limited to a specific flow-regime in the water pool, thermal hydraulic conditions or even to a specific geometry. In this context, the present work aims to develop an empirical correlation to cover the flow regimes from bubbly to churn turbulent, and could be applied to a wide range of geometries. The present correlation shows an increase until a maximum entrainment of about 2.10-4, corresponding to superficial gas velocity of 0.05 m/s for bubbly flow regime, and then a slight decrease to 2⋅10􀀀 5, for the transition regime corresponding superficial gas velocity of 0.1 m/s, and a sharp increase in the churn turbulent flow regime as the gas velocity goes up to 5 m/s. The experimental database used to develop the present empirical correlation covers a broader range of boundary conditions, namely pressure [1 bar–15 bar], water pool thermal condition [subcooled – boiling], vessel diameter [0.19 m- 3.2 m], pool diameter [0.1 m–1.4 m], superficial gas velocity up to 5.0 m/s Therefore, the proposed empirical correlation aims to constitute an important tool to transfer the experimental results to reactor application. [less ▲]

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See detail21st century investment protection: Africa’s innovations in investment law reform
Garcia Olmedo, Javier UL

in IBA Arbitration Newsletter (2021)

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See detailA three-dimensional model for the heat and mass transfer in air-gap membrane distillation
Cramer, Kerstin UL; Niceno, Bojan; Prasser, Horst Michael et al

in Desalination and Water Treatment (2021)

Membrane distillation (MD) is a process to desalinate sea water. Pilot plants are operated aiming at increasing the modules’ efficiency for large-scale applications. In air-gap membrane distillation (AGMD ... [more ▼]

Membrane distillation (MD) is a process to desalinate sea water. Pilot plants are operated aiming at increasing the modules’ efficiency for large-scale applications. In air-gap membrane distillation (AGMD) the state-of-the-art modeling of mass and heat transfer is one-dimensional, combining evaporation and diffusion through the membrane and the condenser channel in one correlation. In this work, a numerical model is developed which computes AGMD modules in three dimen- sions. For evaporation and condensation, energy conservation equations at the interfaces are solved. Simulation results are compared to experimental data and a good agreement is found. The model is then employed to compare numerically two air-gap MD module configurations and evaluate their performance at different feed inlet temperatures, velocities and air-gap thicknesses. In the upside configuration, the hot feed flows above the membrane, while in the downside configura- tion it flows below the air-gap and membrane. In the latter, the feed solution is not in contact with the membrane but separated by the air-gap which is expected to improve the fouling resistance of the membrane. The three-dimensional computational fluid dynamic computation allows the visu- alization of the velocity profile in the air-gap due to buoyancy in the downside configuration [less ▲]

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See detailDiagnosis of Diabetic Retinopathy through Retinal Fundus Images and 3D Convolutional Neural Networks with Limited Number of Samples
Tufail, Ahsan Bin; Ullah, Inam; Khan, Wali Ullah UL et al

in Wireless Communications and Mobile Computing (2021)

Diabetic retinopathy (DR) is a worldwide problem associated with the human retina. It leads to minor and major blindness and is more prevalent among adults. Automated screening saves time of medical care ... [more ▼]

Diabetic retinopathy (DR) is a worldwide problem associated with the human retina. It leads to minor and major blindness and is more prevalent among adults. Automated screening saves time of medical care specialists. In this work, we have used different deep learning (DL) based 3D convolutional neural network (3D-CNN) architectures for binary and multiclass (5 classes) classification of DR. We have considered mild, moderate, no, proliferate, and severe DR categories. We have deployed two artificial data augmentation/enhancement methods: random weak Gaussian blurring and random shift along with their combination to accomplish these tasks in the spatial domain. In the binary classification case, we have found the performance of 3D-CNN architecture trained by deploying combined augmentation methods to be the best, while in the multiclass case, the performance of model trained without augmentation is the best. It is observed that the DL algorithms working with large volumes of data may achieve better performances as compared to the methods working with small volumes of data. [less ▲]

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See detailInternet service providers as law enforcers and adjudicators. A public role of private actors
Tosza, Stanislaw UL

in Computer Law & Security Review (2021), 43

Private actors have become increasingly involved in the law enforcement process in recent years, taking up more proactive roles and being increasingly engaged in choices between conflicting rights and ... [more ▼]

Private actors have become increasingly involved in the law enforcement process in recent years, taking up more proactive roles and being increasingly engaged in choices between conflicting rights and freedoms. The development and spread of information and communication technology (ICT) created a set of conditions in which the participation of private actors (service providers in this case) appears to be a necessity. These conditions include, for example, a lack of physical borders for ICT technologies, the speed and width of the spread of information on the Internet, as well as the growth of technological behemoths. The resulting reaction can be seen in various sectors, such as combatting illicit content online or gathering digital evidence. While executing these roles they may be compelled – de jure or de facto – to make value judgments which traditionally belong to the public authorities. At the same time the legal framework is either lacking or it does not fully cover the consequences of this fundamental paradigm shift, to the detriment of the authorities, private actors and persons concerned. The objective of this article is to examine the most important features of these developments and analyse resulting key legal problems. The author demonstrates that the legal landscape of cooperation between law enforcement and service providers must be rethought and offers a direction for this reflection. [less ▲]

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See detailThe Health Effects of Workforce Involvement and Transitions for Europeans 50–75 Years of Age: Heterogeneity by Financial Difficulties and Gender
Settels, Jason UL

in Canadian Journal on Aging (2021)

A prominent demographic trend throughout the industrialized world is population aging. Concerns about economic growth and labour force shortages have led many European nations to enact policies aimed at ... [more ▼]

A prominent demographic trend throughout the industrialized world is population aging. Concerns about economic growth and labour force shortages have led many European nations to enact policies aimed at prolonging working life. Understanding how paid work among late-middle-aged and senior adults is associated with health is therefore important. Using a sample of persons who were 50–75 years of age in 2015 from waves six (2015) and seven (2017) of the Survey of Health, Ageing and Retirement in Europe (n = 38,884), this study shows how a comprehensive set of six workforce involvement/transitions patterns are associated with health. The results show benefits of paid work, especially among respondents having financial difficulties. There is further heterogeneity by gender. The more fragmented employment histories of 50–75-year-old women are associated with stable paid work being of less benefit for addressing financial difficulties and with their health being especially vulnerable to unemployment while they are undergoing financial troubles. [less ▲]

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See detailSouth African speleothems reveal influence of high- and low- latitude forcing over the past 113.5 k.y.
Chase, Brian; Harris, Chris; de Wit, Maarten et al

in Geology (2021), 49(11), 1353-1357

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See detailTherapeutic maps for a sensor-based evaluation of deep brain stimulation programming
Bremm, René Peter UL; Berthold, Christophe; Krüger, Rejko UL et al

in Biomedizinische Technik. Biomedical Engineering (2021)

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See detailSuper-Heisenberg scaling in Hamiltonian parameter estimation in the long-range Kitaev chain
Yang, Jing UL; Pang, Shengshi; Del Campo Echevarria, Adolfo UL et al

in Physical Review Research (2021)

In quantum metrology, nonlinear many-body interactions can enhance the precision of Hamiltonian parameter estimation to surpass the Heisenberg scaling. Here, we consider the estimation of the interaction ... [more ▼]

In quantum metrology, nonlinear many-body interactions can enhance the precision of Hamiltonian parameter estimation to surpass the Heisenberg scaling. Here, we consider the estimation of the interaction strength in linear systems with long-range interactions and using the Kitaev chains as a case study, we establish a transition from the Heisenberg to super-Heisenberg scaling in the quantum Fisher information by varying the interaction range. We further show that quantum control can improve the prefactor of the quantum Fisher information. Our results explore the advantage of optimal quantum control and long-range interactions in many-body quantum metrology. [less ▲]

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See detailHybrid Beamforming for Terahertz Joint Ultra-Massive MIMO Radar-Communications
Elbir, Ahmet M.; Mishra, Kumar Vjiay; Chatzinotas, Symeon UL

in IEEE Journal of Selected Topics in Signal Processing (2021), 15(6), 1468-1483

In this paper, we investigate the hybrid beamforming problem in joint radar-communications at terahertz (THz) bands. In order to address the extremely high attenuation at THz, ultra-massive multiple-input ... [more ▼]

In this paper, we investigate the hybrid beamforming problem in joint radar-communications at terahertz (THz) bands. In order to address the extremely high attenuation at THz, ultra-massive multiple-input multiple-output (UM-MIMO) antenna systems have been proposed for THz communications to compensate propagation losses. Further, we propose a new group-of-subarrays (GoSA) UM-MIMO structure to reduce the hardware cost. We formulate the GoSA beamformer design as an optimization problem to provide a trade-off between the unconstrained communications beamformers and the desired radar beamformers. Numerical experiments demonstrate that the proposed approach outperforms the conventional approaches in terms of spectral efficiency and hardware costs. [less ▲]

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See detailAI Crimes and Misdemeanors: Debating the Boundaries of Criminal Liability and Imputation
Moraiti, Anna UL

in Revue Internationale de Droit Pénal (2021), 92(1),

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See detailAnalysing travel satisfaction of tourists towards a metro system from unstructured data
Pineda Jaramillo, Juan Diego UL; Pineda-Jaramillo, Daniel

in Research in Transportation Business and Management (2021)

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See detailDownlink Transmit Design in Massive MIMO LEO Satellite Communications
Li, Ke-Xin; You, Li; Want, Jiaheng et al

in IEEE Transactions on Communications (2021)

Low earth orbit (LEO) satellite communication systems have attracted extensive attention due to their smaller pathloss, shorter round-trip delay and lower launch cost compared with geostationary ... [more ▼]

Low earth orbit (LEO) satellite communication systems have attracted extensive attention due to their smaller pathloss, shorter round-trip delay and lower launch cost compared with geostationary counterparts. In this paper, the downlink transmit design for massive multiple-input multiple-output (MIMO) LEO satellite communications is investigated. First, we establish the massive MIMO LEO satellite channel model where the satellite and user terminals (UTs) are both equipped with the uniform planar arrays. Then, the rank of transmit covariance matrix of each UT is shown to be no larger than one to maximize ergodic sum rate, which reveals the optimality of single-stream precoding for each UT. The minorization-maximization algorithm is used to compute the precoding vectors. To reduce the computation complexity, an upper bound of ergodic sum rate is resorted to produce a simplified transmit design, where the rank of optimal transmit covariance matrix of each UT is also shown to not exceed one. To tackle the simplified precoder design, we derive the structure of precoding vectors, and formulate a Lagrange multiplier optimization (LMO) problem building on the structure. Then, a low-complexity algorithm is devised to solve the LMO, which takes much less computation effort. Simulation results verify the performance of proposed approaches. [less ▲]

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See detailNovel optofluidic concepts enabled by topological microfluidics
Sengupta, Anupam UL

in EPJ Web of Conferences (2021), 255(10002), 1-6

The coupling between flow and director orientation of liquid crystals (LCs) has been long utilized to devise wide-ranging applications spanning modern displays, medical and environmental solutions, and ... [more ▼]

The coupling between flow and director orientation of liquid crystals (LCs) has been long utilized to devise wide-ranging applications spanning modern displays, medical and environmental solutions, and bio-inspired designs and applications. LC-based optofluidic platforms offer a non-invasive handle to modulate light and material fields, both locally and dynamically. The flow-driven reorientation of the LC molecules can tailor distinct optical and mechanical responses in microfluidic confinements, and harness the coupling therein. Yet the synergy between traditional optofluidics with isotropic fluids and LC microfluidics remains at its infancy. Here, we discuss emerging optofluidic concepts based on Topological Microfluidics, leveraging microfluidic control of topological defects and defect landscapes. With a specific focus on the role of surface anchoring and microfluidic geometry, we present recent and ongoing works that harness flow-controlled director and defect configurations to modulate optical fields. The flow-induced optical attributes, and the corresponding feedback, is enhanced in the vicinity of the topological defects which geenerate distinct isotropic opto-material properties within an anisotropic matrix. By harnessing the rich interplay of confining geometry, anchoring and micro-scale nematodynamics, topological microfluidics offers a promising platform to ideate the next generation of optofluidic and optomechnical concepts. [less ▲]

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See detailThe Socioeconomic gradient in child health and noncognitive skills: Evidence from the Czech Republic
Borga, Liyousew UL; Munich, Daniel; Kukla, Lubomir

in Economics and Human Biology (2021)

We investigate the presence of a socioeconomic status (SES) gradient in children's health and noncognitive skill development, and its evolution with child age using cohort data from the Czech Republic. We ... [more ▼]

We investigate the presence of a socioeconomic status (SES) gradient in children's health and noncognitive skill development, and its evolution with child age using cohort data from the Czech Republic. We show that family SES are positively associated with better child health. These effects start to emerge at age 3 and are persistent for all subsequent ages. We find a modest strengthening of the gradient as the children grow older. Similarly, at the lowest distribution of average family income, children lag in their noncognitive skills. We find evidence that children enter school with substantial differences in noncognitive skill endowments based on family SES. This correlation persists when controlling for poor health at birth, the roles of specific and chronic health problems, housing conditions, and partner characteristics. Maternal health status explains some of the association between family income and child noncognitive skills. We account for the endogeniety of SES and non-linearities in measures. [less ▲]

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See detailGenome Sequencing of SARS-CoV-2 Allows Monitoring of Variants of Concern through Wastewater
Herold, Malte; Fouquier d'herouël, Aymeric UL; May, Patrick UL et al

in Water (2021), 13(21 3018),

Monitoring SARS-CoV-2 in wastewater has shown to be an effective tool for epidemiological surveillance. More specifically, RNA levels determined with RT-qPCR have been shown to track with the infection ... [more ▼]

Monitoring SARS-CoV-2 in wastewater has shown to be an effective tool for epidemiological surveillance. More specifically, RNA levels determined with RT-qPCR have been shown to track with the infection dynamics within the population. However, the surveillance of individual lineages circulating in the population based on genomic sequencing of wastewater samples is challenging, as the genetic material constitutes a mixture of different viral haplotypes. Here, we identify specific signature mutations from individual SARS-CoV-2 lineages in wastewater samples to estimate lineages circulating in Luxembourg. We compare circulating lineages and mutations to those detected in clinical samples amongst infected individuals. We show that especially for dominant lineages, the allele frequencies of signature mutations correspond to the occurrence of particular lineages in the population. In addition, we provide evidence that regional clusters can also be discerned. We focused on the time period between November 2020 and March 2021 in which several variants of concern emerged and specifically traced the lineage B.1.1.7, which became dominant in Luxembourg during that time. During the subsequent time points, we were able to reconstruct short haplotypes, highlighting the co-occurrence of several signature mutations. Our results highlight the potential of genomic surveillance in wastewater samples based on amplicon short-read data. By extension, our work provides the basis for the early detection of novel SARS-CoV-2 variants. [less ▲]

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See detailTopology and Phase Transitions: A First Analytical Step towards the Definition of Sufficient Conditions
di Cairano, Loris UL; Gori, Matteo UL; Pettini, Marco

in Entropy (2021), 23(11),

Different arguments led to supposing that the deep origin of phase transitions has to be identified with suitable topological changes of potential related submanifolds of configuration space of a physical ... [more ▼]

Different arguments led to supposing that the deep origin of phase transitions has to be identified with suitable topological changes of potential related submanifolds of configuration space of a physical system. An important step forward for this approach was achieved with two theorems stating that, for a wide class of physical systems, phase transitions should necessarily stem from topological changes of energy level submanifolds of the phase space. However, the sufficiency conditions are still a wide open question. In this study, a first important step forward was performed in this direction; in fact, a differential equation was worked out which describes how entropy varies as a function of total energy, and this variation is driven by the total energy dependence of a topology-related quantity of the relevant submanifolds of the phase space. Hence, general conditions can be in principle defined for topology-driven loss of differentiability of the entropy [less ▲]

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See detailRoadmap on organic–inorganic hybrid perovskite semiconductors and devices
Schmidt-Mende, Lukas; Dyakonov, Vladimir; Olthof, Selina et al

in APL Materials (2021)

Metal halide perovskites are the first solution processed semiconductors that can compete in their functionality with conventional semiconductors, such as silicon. Over the past several years, perovskite ... [more ▼]

Metal halide perovskites are the first solution processed semiconductors that can compete in their functionality with conventional semiconductors, such as silicon. Over the past several years, perovskite semiconductors have reported breakthroughs in various optoelectronic devices, such as solar cells, photodetectors, light emitting and memory devices, and so on. Until now, perovskite semiconductors face challenges regarding their stability, reproducibility, and toxicity. In this Roadmap, we combine the expertise of chemistry, physics, and device engineering from leading experts in the perovskite research community to focus on the fundamental material properties, the fabrication methods, characterization and photophysical properties, perovskite devices, and current challenges in this field. We develop a comprehensive overview of the current state-of-the-art and offer readers an informed perspective of where this field is heading and what challenges we have to overcome to get to successful commercialization. [less ▲]

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See detailGenetic evaluation of dementia with Lewy bodies implicates distinct disease subgroups
Kaivola, Karri; Shah, Zalak; Chia, Ruth et al

in Brain: a Journal of Neurology (2021), awab402

The APOE locus is strongly associated with risk for developing Alzheimer’s disease and dementia with Lewy bodies (DLB). In particular, the role of the APOE ε4 allele as a putative driver of α-synuclein ... [more ▼]

The APOE locus is strongly associated with risk for developing Alzheimer’s disease and dementia with Lewy bodies (DLB). In particular, the role of the APOE ε4 allele as a putative driver of α-synuclein pathology is a topic of intense debate. Here, we performed a comprehensive evaluation in 2,466 DLB cases versus 2,928 neurologically healthy, aged controls. Using an APOE-stratified genome-wide association study approach, we found that GBA is associated with risk for DLB in patients without APOE ε4 (p = 6.58 x 10−9, OR = 3.41, 95% CI = 2.25–5.17), but not with DLB with APOE ε4 (p = 0.034, OR = 1.87, 95%, 95% CI = 1.05–3.37). We then divided 495 neuropathologically examined DLB cases into three groups based on the extent of concomitant Alzheimer’s disease co-pathology: pure DLB (n = 88), DLB with intermediate Alzheimer’s disease co-pathology (DLB + iAD, n = 66), and DLB with high Alzheimer’s disease co-pathology (DLB + AD, n = 341). In each group, we tested the association of the APOE ε4 against the 2,928 neurologically healthy controls. Our examination found that APOE ε4 was associated with DLB + AD (p = 1.29x10−32, OR = 4.25, 95% CI = 3.35–5.39) and DLB + iAD (p = 0.0011, OR = 2.31, 95% CI = 1.40–3.83), but not with pure DLB (p = 0.31, OR = 0.75, 95% CI = 0.43–1.30). In conclusion, though deep clinical data were not available for these samples, our findings do not support the notion that APOE ε4 is an independent driver of α-synuclein pathology in pure DLB, but rather implicate GBA as the main risk gene for the pure DLB subgroup. [less ▲]

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See detailJudicial review of EU soft law: a revolutionary step which has not fully happened (Case note on BT v. Balgarska Narodna Banka, C-501/18)
Hubkova, Pavlina UL

in Revista General de Derecho Europeo (2021), (55),

In the judgment in case BT v Balgarska Narodna Banka, the Court of Justice of the EU declared, for the first time, invalid a part of a legally non-binding EU act – a recommendation adopted by the European ... [more ▼]

In the judgment in case BT v Balgarska Narodna Banka, the Court of Justice of the EU declared, for the first time, invalid a part of a legally non-binding EU act – a recommendation adopted by the European Banking Authority and addressed to the Bulgarian National Bank. It also confirmed that the referring court deciding upon damages has a duty to take such a recommendation into consideration. Moreover, the individuals in the national proceedings should have a right to rely upon the content of the recommendation even if they are not addressees of such an act. However, when assessed in more detail, the case points out to several interesting aspects related to EU soft law that have not been properly discussed yet. [less ▲]

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See detailEU Law and the ECT as Distinct and Separate Legal Regimes: A Case Comment on Eskosol v Italy, Decision on Request for Immediate Termination and Jurisdictional Objection Based on the Inapplicability of the ECT to Intra-EU Disputes, 7 May 2019
Happold, Matthew UL

in ICSID Review (2021), 36(2), 278-285

This case comment examines the decision of the tribunal in Eskosol v Italy rejecting the respondent’s jurisdictional objections based on the inapplicability of the Energy Charter Treaty to intra-EU ... [more ▼]

This case comment examines the decision of the tribunal in Eskosol v Italy rejecting the respondent’s jurisdictional objections based on the inapplicability of the Energy Charter Treaty to intra-EU disputes. In particular, it examines the tribunal's construction of a division between EU law and the ECT, emphasizing the separate and distinct characters of the two regimes, with the twin ambitions of making intra-EU arbitration under the ECT less objectionable from an EU law perspective while maintaining the autonomy of ECT arbitral tribunals. Whether the tribunal's first objective is feasible, however, is doubted and the extent to which intra-EU arbitration under the ECT has a future questioned. [less ▲]

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See detailContesting war memories: Parties and voters in contemporary Southeast Europe
Glaurdic, Josip UL; Lesschaeve, Christophe UL; Mochtak, Michal UL

in Party Politics (2021)

Over the past four decades, there has been a proliferation of interest in the causes, consequences, and dynamics of contestation over collective memories across a variety of fields. Unfortunately ... [more ▼]

Over the past four decades, there has been a proliferation of interest in the causes, consequences, and dynamics of contestation over collective memories across a variety of fields. Unfortunately, collective memories—particularly those of traumatic experiences of violence such as wars and revolutions—have been largely absent from party politics research. Using data collected in an expert survey on the policy positions and ideological orientations of all relevant political parties, as well as an extensive survey of more than ten thousand voters in the six post-conflict countries of Southeast Europe, we demonstrate that collective memories of war are not only subjects of historiographical contestation but are also significant sources of ideological and policy differentiation among political parties, as well as one of the strongest determinants of voter choice. Our analysis shows that collective memories are politically contested and that party politics research would benefit from taking them seriously. [less ▲]

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See detailLongitudinal Assessment of Physical Activity, Fitness, Body Composition, Immunological Biomarkers, and Psychological Parameters During the First Year After Diagnosis in Women With Non-Metastatic Breast Cancer: The BEGYN Study Protocol
Zemlin, Cosima; Stuhlert, Caroline; Schleicher, Julia Theresa et al

in Frontiers in Oncology (2021), 11

Background: Moderate physical activity is associated with an improved prognosis and psychosocial outcome in breast cancer patients. Although exercise and physical activity are associated with multiple ... [more ▼]

Background: Moderate physical activity is associated with an improved prognosis and psychosocial outcome in breast cancer patients. Although exercise and physical activity are associated with multiple physiological and psychological effects, many of the underlying mechanisms remain obscure. The BEGYN study (Influence of physical activity in breast cancer patients on physiological and psychological parameters and on biomarkers) aims at identifying potential associations between the extent of physical activity, fitness, body composition, immunological biomarkers, psycho-emotional parameters, and the course of treatment during the first year after diagnosis of breast cancer. Methods: The prospective observational BEGYN study will include 110 non-metastatic breast cancer patients. The patients will be assessed during a base line visit prior to the initiation of the antineoplastic therapy and after 3, 6, 9 and 12 months. The physical activity will be measured using a fitness tracker and a self-assessment diary during the entire study. Each visit will include the assessment of (i) cardiorespiratory fitness measured by spiroergometry, (ii) body composition, (iii) psycho-emotional parameters (quality of life, mental health, fatigue, depression, distress, anxiety, well-being), and (iv) extensive blood tests including routine laboratory, vitamin D, selenium and immunologically relevant biomarkers (e.g., leukocyte subpopulations and cytokine profiles). Discussion: Whereas most studies investigating the influence of physical activity in breast cancer patients focus on specific activities for three months or less, the BEGYN study will quantify the daily physical activity and cardiorespiratory fitness of breast cancer patients based on objective measurements in the context of the oncological therapy for 12 months after diagnosis. The study will reveal potential associations between exercise, immune status and physical as well as psycho-emotional outcome and the clinical course of the disease. Moreover, complementary therapies such as Vit D and Selenium supplementation and parameters investigating the motivation of the patients are part of the study. Due to this holistic approach, the BEGYN study will guide towards confirmatory studies on the role of physical activity in breast cancer patients to develop individualized counselling regarding the recommended type and extent of exercise. [less ▲]

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See detailThroughput Enhancement in FD- and SWIPT-enabled IoT Networks over Non-Identical Rayleigh Fading Channel
Nguyen, Nhat Tan; Tran Dinh, Hieu UL; Chatzinotas, Symeon UL et al

in IEEE Internet of Things Journal (2021)

Simultaneous wireless information and power transfer (SWIPT) and full-duplex (FD) communications have emerged as prominent technologies in overcoming the limited energy resources in Internet-of-Things ... [more ▼]

Simultaneous wireless information and power transfer (SWIPT) and full-duplex (FD) communications have emerged as prominent technologies in overcoming the limited energy resources in Internet-of-Things (IoT) networks and improving their spectral efficiency (SE). The article investigates the outage and throughput performance for a decode-and-forward (DF) relay SWIPT system, which consists of one source, multiple relays, and one destination. The relay nodes in this system can harvest energy from the source’s signal and operate in FD mode. A suboptimal, low-complexity, yet efficient relay selection scheme is also proposed. Specifically, a single relay is selected to convey information from a source to a destination so that it achieves the best channel from the source to the relays. An analysis of outage probability (OP) and throughput performed on two relaying strategies, termed static power splitting-based relaying (SPSR) and optimal dynamic power splitting-based relaying (ODPSR), is presented. Notably, we considered independent and non-identically distributed (i.n.i.d.) Rayleigh fading channels, which pose new challenges in obtaining analytical expressions. In this context, we derived exact closed-form expressions of the OP and throughput of both SPSR and ODPSR schemes. We also obtained the optimal power splitting ratio of ODPSR for maximizing the achievable capacity at the destination. Finally, we present extensive numerical and simulation results to confirm our analytical findings. Both simulation and analytical results show the superiority of ODPSR over SPSR. [less ▲]

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See detailNear surface defects: Cause of deficit between internal and external open-circuit voltage in solar cells
Sood, Mohit UL; Urbanaik, Aleksander; Kameni Boumenou, Christian UL et al

in Progress in Photovoltaics (2021)

Interface recombination in a complex multilayered thin-film solar structure causes a disparity between the internal open-circuit voltage (VOC,in), measured by photoluminescence, and the external open ... [more ▼]

Interface recombination in a complex multilayered thin-film solar structure causes a disparity between the internal open-circuit voltage (VOC,in), measured by photoluminescence, and the external open-circuit voltage (VOC,ex), that is, a VOC deficit. Aspirations to reach higher VOC,ex values require a comprehensive knowledge of the connection between VOC deficit and interface recombination. Here, a near-surface defect model is developed for copper indium di-selenide solar cells grown under Cu-excess conditions. These cell show the typical signatures of interface recombination: a strong disparity between VOC,in and VOC,ex, and extrapolation of the temperature dependent q·VOC,ex to a value below the bandgap energy. Yet, these cells do not suffer from reduced interface bandgap or from Fermi-level pinning. The model presented is based on experimental analysis of admittance and deep-level transient spectroscopy, which show the signature of an acceptor defect. Numerical simulations using the near-surface defects model show the signatures of interface recombination without the need for a reduced interface bandgap or Fermi-level pinning. These findings demonstrate that the VOC,in measurements alone can be inconclusive and might conceal the information on interface recombination pathways, establishing the need for complementary techniques like temperature dependent current–voltage measurements to identify the cause of interface recombination in the devices. [less ▲]

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See detailEvasion Attack STeganography: Turning Vulnerability Of Machine Learning ToAdversarial Attacks Into A Real-world Application
Ghamizi, Salah UL; Cordy, Maxime UL; Papadakis, Mike UL et al

in Proceedings of International Conference on Computer Vision 2021 (2021)

Evasion Attacks have been commonly seen as a weakness of Deep Neural Networks. In this paper, we flip the paradigm and envision this vulnerability as a useful application. We propose EAST, a new ... [more ▼]

Evasion Attacks have been commonly seen as a weakness of Deep Neural Networks. In this paper, we flip the paradigm and envision this vulnerability as a useful application. We propose EAST, a new steganography and watermarking technique based on multi-label targeted evasion attacks. Our results confirm that our embedding is elusive; it not only passes unnoticed by humans, steganalysis methods, and machine-learning detectors. In addition, our embedding is resilient to soft and aggressive image tampering (87% recovery rate under jpeg compression). EAST outperforms existing deep-learning-based steganography approaches with images that are 70% denser and 73% more robust and supports multiple datasets and architectures. [less ▲]

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See detailAre Firms Withdrawing From Basic Research? An Analysis of Firm-level Publication Behaviour in Germany
Krieger, Bastian UL; Blind, Knut; Gruber, Sonia et al

in Scientometrics (2021), 126

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See detailLeveraging High-Frequency Components for Deepfake Detection
Mejri, Nesryne UL; Papadopoulos, Konstantinos UL; Aouada, Djamila UL

in IEEE Workshop on Multimedia Signal Processing (2021)

In the past years, RGB-based deepfake detection has shown notable progress thanks to the development of effective deep neural networks. However, the performance of deepfake detectors remains primarily ... [more ▼]

In the past years, RGB-based deepfake detection has shown notable progress thanks to the development of effective deep neural networks. However, the performance of deepfake detectors remains primarily dependent on the quality of the forged content and the level of artifacts introduced by the forgery method. To detect these artifacts, it is often necessary to separate and analyze the frequency components of an image. In this context, we propose to utilize the high-frequency components of color images by introducing an end-to-end trainable module that (a) extracts features from high-frequency components and (b) fuses them with the features of the RGB input. The module not only exploits the high-frequency anomalies present in manipulated images but also can be used with most RGB-based deepfake detectors. Experimental results show that the proposed approach boosts the performance of state-of-the-art networks, such as XceptionNet and EfficientNet, on a challenging deepfake dataset. [less ▲]

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See detailPerformance assessment of the relative gravimeter Scintrex CG-6
Francis, Olivier UL

in Journal of Geodesy (2021), 95:116

The new-generation relative gravimeter Scintrex CG6 is put on the test bench: Its performance is compared to its predecessor, the Scintrex-CG5. A CG5 Scintrex and a CG6 Scintrex were both submitted to the ... [more ▼]

The new-generation relative gravimeter Scintrex CG6 is put on the test bench: Its performance is compared to its predecessor, the Scintrex-CG5. A CG5 Scintrex and a CG6 Scintrex were both submitted to the same rigorous tests, which have been developed in recent years to highlight some defects of the CG5. The results show that the CG6 always performs better than the CG5. For instance, the instrumental drift is 5 times smaller for the CG6 than for the CG5. In the tidal bands, the noise level of the CG6 is 3 times lower than of the one of the CG5. We confirmed the tilt susceptibility of the CG5 and found that the CG6 is barely affected by long duration tilts before taking measurements. Unlike the CG5, the CG6 measurements are not influenced by external temperature variations. Overall, the CG6 provides more precise and stable gravity measurements compared to the CG5. [less ▲]

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See detailMendelian randomization study of smoking, alcohol, and coffee drinking in relation to Parkinso's disease
Domenighetti, Cloe; Sugier, Pierre Emmanuel; Sreelatha, Ashwin Ashok Kumar et al

in Journal of Parkinson's Disease (2021)

Background:Previous studies showed that lifestyle behaviors (cigarette smoking, alcohol, coffee) are inversely associated with Parkinson’s disease (PD). The prodromal phase of PD raises the possibility ... [more ▼]

Background:Previous studies showed that lifestyle behaviors (cigarette smoking, alcohol, coffee) are inversely associated with Parkinson’s disease (PD). The prodromal phase of PD raises the possibility that these associations may be explained by reverse causation. Objective:To examine associations of lifestyle behaviors with PD using two-sample Mendelian randomisation (MR) and the potential for survival and incidence-prevalence biases. Methods:We used summary statistics from publicly available studies to estimate the association of genetic polymorphisms with lifestyle behaviors, and from Courage-PD (7,369 cases, 7,018 controls; European ancestry) to estimate the association of these variants with PD. We used the inverse-variance weighted method to compute odds ratios (ORIVW) of PD and 95%confidence intervals (CI). Significance was determined using a Bonferroni-corrected significance threshold (p = 0.017). Results:We found a significant inverse association between smoking initiation and PD (ORIVW per 1-SD increase in the prevalence of ever smoking = 0.74, 95%CI = 0.60–0.93, p = 0.009) without significant directional pleiotropy. Associations in participants ≤67 years old and cases with disease duration ≤7 years were of a similar size. No significant associations were observed for alcohol and coffee drinking. In reverse MR, genetic liability toward PD was not associated with smoking or coffee drinking but was positively associated with alcohol drinking. Conclusion:Our findings are in favor of an inverse association between smoking and PD that is not explained by reverse causation, confounding, and survival or incidence-prevalence biases. Genetic liability toward PD was positively associated with alcohol drinking. Conclusions on the association of alcohol and coffee drinking with PD are hampered by insufficient statistical power. [less ▲]

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See detailDigital Identities and Verifiable Credentials
Sedlmeir, Johannes UL; Smethurst, Reilly UL; Rieger, Alexander UL et al

in Business and Information Systems Engineering (2021), 63(5), 603-613

Public institutions and companies typically employ physical credentials (such as passports, social security cards, and employee badges) to identify individuals. Individuals can choose where to store their ... [more ▼]

Public institutions and companies typically employ physical credentials (such as passports, social security cards, and employee badges) to identify individuals. Individuals can choose where to store their physical credentials, and sometimes, they can decide to whom their credentials are disclosed. These familiar privileges inspired a new type of digital credential called a verifiable credential (VC). Similar to physical credentials, individuals can store their verifiable credentials in a so-called digital wallet on their mobile phone, on another edge device, or in the cloud, and they can use verifiable credentials for identification, authentication, and authorization. [less ▲]

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See detailSeeking 'truth' after devastating, multi-layered conflict: The complex case of transitional justice in South Sudan
Owiso, Owiso UL

in Journal of International Humanitarian Legal Studies (2021)

In August 2015, the Government of South Sudan and other parties to the country’s civil conflict signed a peace agreement, the Agreement on the Resolution of the Conflict in the Republic of South Sudan ... [more ▼]

In August 2015, the Government of South Sudan and other parties to the country’s civil conflict signed a peace agreement, the Agreement on the Resolution of the Conflict in the Republic of South Sudan, aimed at ending the civil conflict that broke out on 15 December 2013. After this agreement failed to hold, South Sudan descended into a second wave of civil conflict. A recommitment to the agreement was secured through regional efforts on 12 September 2018. Dubbed the Revitalised Agreement on the Resolution of the Conflict in the Republic of South Sudan, the agreement provides a transitional justice architecture which includes a truth commission, a hybrid court and a reparations authority. This paper examines the potential of the proposed Commission for Truth, Reconciliation and Healing to contribute towards sustainable transitional justice solutions in South Sudan, based on contemporary standards and practice of transitional justice. Through historical, descriptive and analytical approaches, the paper grapples with South Sudan’s complex truth-seeking journey following years of multi-layered conflict. [less ▲]

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See detailIntegrated STEAM Approach in Outdoor Trails with Elementary School Pre-service Teachers in Luxemburg
Haas, Ben; Kreis, Yves UL; Lavicza, Zsolt

in Educational Technology and Society (2021), 24(4), 205-219

Due to the COVID-19 pandemic it was impossible to carry out on-campus teaching and examinations as planned for the first-year elementary school Bachelor’s degree teacher training courses during the summer ... [more ▼]

Due to the COVID-19 pandemic it was impossible to carry out on-campus teaching and examinations as planned for the first-year elementary school Bachelor’s degree teacher training courses during the summer term of 2019/2020. Therefore, we moved our on-campus STEAM (Science, Technology, Engineering, Arts and Mathematics) related courses to schooling at home. For their course examination, students designed outdoor trails in groups with the educational technology MathCityMap based on an integrated STEAM approach. Hence, they combined STEAM with real-world situations (e.g., monuments, marketplaces, playgrounds). The tasks within the trails required the use of technologies such as augmented reality (AR), digital modelling (e.g., GeoGebra 3D Graphing Calculator), and GPS. Analogue measuring tools (e.g., triangle ruler) were also used in the task designs. We collected data from 21 trails with 259 tasks from 49 pre-service teachers to analyse the effects on professional growth in STEAM education. Through hierarchical cluster analysis we identified three different clusters with patterns regarding STEAM in outdoor trails. This paper will describe a pedagogical framework for the integrated STEAM approach to designing and evaluating outdoor trails. Furthermore, we will explain patterns pre-service teachers developed during this professional development. [less ▲]

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See detailIs the Z2xZ2-graded sine-Gordon equation integrable?
Bruce, Andrew UL

in Nuclear Physics B (2021), 971

We examine the question of the integrability of the recently defined Z2xZ2-graded sine-Gordon model, which is a natural generalisation of the supersymmetric sine-Gordon equation. We do this via ... [more ▼]

We examine the question of the integrability of the recently defined Z2xZ2-graded sine-Gordon model, which is a natural generalisation of the supersymmetric sine-Gordon equation. We do this via appropriate auto-Bäcklund transformations, construction of conserved spinor-valued currents and a pair of infinite sets of conservation laws. [less ▲]

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See detailTask Offloading and Resource Allocation for IoV Using 5G NR-V2X Communication
Raza, Salman; Wang, Shangguang; Ahmed, Manzoor et al

in IEEE Internet of Things Journal (2021)

Vehicular edge computing (VEC) is an innovative computing paradigm with an exceptional ability to improve the vehicles’ capacity to manage computation-intensive applications with both low latency and ... [more ▼]

Vehicular edge computing (VEC) is an innovative computing paradigm with an exceptional ability to improve the vehicles’ capacity to manage computation-intensive applications with both low latency and energy consumption. Vehicles require to make task offloading decisions in dynamic network conditions to obtain maximum computation efficiency. In this article, we analyze computation efficiency in a VEC scenario, where a vehicle offloads its tasks to maximize computation efficiency as a tradeoff between computation time and energy consumption. Although, it is quite a challenge to ensure the quality of experience of the vehicle due to diverse task requirements and the dynamic wireless conditions caused by vehicle mobility. To tackle this problem, a computation efficiency problem is formulated by jointly optimizing task offloading decision and computation resource allocation. We propose a mobility-aware computational efficiency-based task offloading and resource allocation (MACTER) scheme and develop a distributed MACTER algorithm that provides the near-optimal solution. We further consider the fifth-generation new-radio vehicle-to-everything communication model, i.e., cellular link and millimeter wave, to enhance the system performance. The simulation outcomes demonstrate that the proposed algorithm can efficiently enhance computation efficiency while satisfying computing time and energy consumption constraints. [less ▲]

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See detailOn pyramids, prisms, and scalable reading
Fickers, Andreas UL; Clavert, Frédéric UL

in Journal of Digital History (2021), 1(1),

Since Robert Darnton’s 1999 essay sketched a broad vision of what could become historical scholarship, many scholars have tried to put into practice new ways to publish in the digital era. Inspired by the ... [more ▼]

Since Robert Darnton’s 1999 essay sketched a broad vision of what could become historical scholarship, many scholars have tried to put into practice new ways to publish in the digital era. Inspired by the concept of digital hermeneutics, the Journal of Digital History – a joint venture between the C2DH and De Gruyter Publishing group – proposes to put Darnton’s vision into reality by offering a multi-layered publication platform for data-driven scholarship in the field of digital history. [less ▲]

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See detailLocal Forms of Morphisms of Colored Supermanifolds
Covolo, Tiffany; Kwok, Stephen; Poncin, Norbert UL

in Journal of Geometry and Physics (2021), 168

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See detailAnalysis of residual stress relaxation of aluminum alloys EN AW 6061/-82 T6 under cyclic loading
Repplinger, Christian UL; Sellen, Stephan UL; Kedziora, Slawomir UL et al

in Fatigue and Fracture of Engineering Materials and Structures (2021)

Stress relaxation describes the reduction of stress under static or cyclic loading at a constant strain level. Several processes induce intentionally residual stresses, for example, autofrettage of thick ... [more ▼]

Stress relaxation describes the reduction of stress under static or cyclic loading at a constant strain level. Several processes induce intentionally residual stresses, for example, autofrettage of thick-walled pressurized tubes to improve their fatigue life. This well-known process induces residual compressive stresses at the critical inner surface by using a single static but controlled over- loading internal pressure. Relaxation of residual stresses due to cyclic loading in service would endanger the effectiveness of autofrettage and could finally lead to unexpected fatigue failure. In this study, strain-controlled experiments up to 500,000 load cycles and amending nonlinear finite element simulations were done for the aluminum alloys EN AW 6061 T6 and EN AW 6082 T6 to study potential cyclic stress relaxation in four-point bending tests after con- trolled single static plasticization for residual stress generation. This analysis identifies almost stable residual stresses for both materials under different cyclic strain-controlled load levels. [less ▲]

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See detailInvestigating Usability and User Experience of Individually Verifiable Internet Voting Schemes
Marky, Karola; Zollinger, Marie-Laure UL; Roenne, Peter et al

in ACM Transactions on Computer-Human Interaction (2021), 28(5), 1-36

Internet voting can afford more inclusive and inexpensive elections. The flip side is that the integrity of the election can be compromised by adversarial attacks and malfunctioning voting infrastructure ... [more ▼]

Internet voting can afford more inclusive and inexpensive elections. The flip side is that the integrity of the election can be compromised by adversarial attacks and malfunctioning voting infrastructure. Individual verifiability aims to protect against such risks by letting voters verify that their votes are correctly registered in the electronic ballot box. Therefore, voters need to carry out additional tasks making human factors crucial for security. In this article, we establish a categorization of individually verifiable Internet voting schemes based on voter interactions. For each category in our proposed categorization, we evaluate a voting scheme in a user study with a total of 100 participants. In our study, we assessed usability, user experience, trust, and further qualitative data to gain deeper insights into voting schemes. Based on our results, we conclude with recommendations for developers and policymakers to inform the choices and design of individually verifiable Internet voting schemes. [less ▲]

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See detailThe Moderating Role of Attention Control in the Relationship Between Pain Catastrophizing and Negatively-Biased Pain Memories in Youth With Chronic Pain
Wauters, Aline; Noel, Melanie; van Ryckeghem, Dimitri UL et al

in Journal of Pain (2021), 22(10), 1303-1314

The present study examined the role of attention control in understanding the development of negatively-biased pain memories as well as its moderating role in the relationship between pain catastrophizing ... [more ▼]

The present study examined the role of attention control in understanding the development of negatively-biased pain memories as well as its moderating role in the relationship between pain catastrophizing and negatively-biased pain memories. Youth with chronic pain (N = 105) performed a cold pressor task (CPT) and completed self-report measures of state/trait pain catastrophizing and attention control, with the latter comprising both attention focusing and attention shifting. Two weeks after the CPT, youth's pain-related memories were elicited via telephone allowing to compute pain and anxiety memory bias indices (ie, recalling pain intensity or pain-related anxiety, respectively, as higher than initially reported). Results indicated no main effects of attention control and pain catastrophizing on pain memories. However, both components of attention control (ie, attention focusing and attention shifting) moderated the impact of pain catastrophizing on youth's memory bias, with opposite interaction effects. Specifically, whereas high levels of attention shifting buffered the influence of high pain catastrophizing on the development of pain memory bias, high levels of attention focusing strengthened the influence of high pain catastrophizing on the development of anxiety memory bias. Interaction effects were confined to trait catastrophizing (ie, not state catastrophizing). Theoretical and clinical implications are discussed. PERSPECTIVE: This article investigates the role of attention control in the development of negatively-biased pain memories in children with chronic pain. Findings underscore the importance of targeting differential components of attention control and can inform intervention efforts to minimize the development of negatively biased pain memories in youth with chronic pain. [less ▲]

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See detailChronique de droit des marchés financiers
Conac, Pierre-Henri UL

in Revue des Sociétés (2021), (10), 608

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See detailNB-IoT Random Access for Non-Terrestrial Networks: Preamble Detection and Uplink Synchronization
Chougrani, Houcine UL; Kisseleff, Steven UL; Alves Martins, Wallace UL et al

in IEEE Internet of Things Journal (2021)

The satellite component is recognized as a promising solution to complement and extend the coverage of future Internet of things (IoT) terrestrial networks (TNs). In this context, a study item to ... [more ▼]

The satellite component is recognized as a promising solution to complement and extend the coverage of future Internet of things (IoT) terrestrial networks (TNs). In this context, a study item to integrate satellites into narrowband-IoT (NBIoT) systems has been approved within the 3rd Generation Partnership Project (3GPP) standardization body. However, as NBIoT systems were initially conceived for TNs, their basic design principles and operation might require some key modifications when incorporating the satellite component. These changes in NB-IoT systems, therefore, need to be carefully implemented in order to guarantee a seamless integration of both TN and non-terrestrial network (NTN) for a global coverage. This paper addresses this adaptation for the random access (RA) step in NBIoT systems, which is in fact the most challenging aspect in the NTN context, for it deals with multi-user time-frequency synchronization and timing advance for data scheduling. In particular, we propose an RA technique which is robust to typical satellite channel impairments, including long delays, significant Doppler effects, and wide beams, without requiring any modification to the current NB-IoT RA waveform. Performance evaluations demonstrate the proposal’s capability of addressing different NTN configurations recently defined by 3GPP for the 5G new radio system. [less ▲]

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See detailAnti-seizure activity of African medicinal plants: The identification of bioactive alkaloids from the stem bark of Rauvolfia caffra using an in vivo zebrafish model
Chipiti, Talent; Viljoen M., Alvaro; Cordero Maldonado, Maria Lorena UL et al

in Journal of Ethnopharmacology (2021), 28(279),

Epilepsy is one of the major chronic diseases that does not have a cure to date. Adverse drug reactions have been reported from the use of available anti-epileptic drugs (AEDs) which are also effective in ... [more ▼]

Epilepsy is one of the major chronic diseases that does not have a cure to date. Adverse drug reactions have been reported from the use of available anti-epileptic drugs (AEDs) which are also effective in only two-thirds of the patients. Accordingly, the identification of scaffolds with promising anti-seizure activity remains an important first step towards the development of new anti-epileptic therapies, with improved efficacy and reduced adverse effects. Herbal medicines are widely used in developing countries, including in the treatment of epilepsy but with little scientific evidence to validate this use. In the search for new epilepsy treatment options, the zebrafish has emerged as a chemoconvulsant-based model for epilepsy, mainly because of the many advantages that zebrafish larvae offer making them highly suitable for high-throughput drug screening. [less ▲]

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See detailAnalysis of the geometrical imperfections of a dry-stacked masonry block based on Miscanthus
Pereira Dias, Patrick; Jesuino Kammer, Vanessa; Waldmann, Daniele UL

in Construction and Building Materials (2021)

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See detailThe Digital Humanities Classroom as a “Node”. From Toolbox to Mindset?
Armaselu, Florentina UL

in DH Benelux Journal (2021), 3(Autumn 2021), 103-115

The paper describes a framework for digital pedagogy and evaluation that combines different approaches – theoretical, application-oriented and project-based –, underpinned by a view of the digital ... [more ▼]

The paper describes a framework for digital pedagogy and evaluation that combines different approaches – theoretical, application-oriented and project-based –, underpinned by a view of the digital humanities classroom metaphorically defined as a “node”. The metaphor encompasses the hybrid character of digital humanities teaching, as a crossing or convergence of paths, which involves the use of various categories of study materials, themes, examples, methodologies and skills, as well as exchange, circulation of ideas and connection with other disciplines. It is assumed that the application of this type of hybrid approach in the course design, together with the coverage of a variety of tools to be studied in class, might foster a reflective mindset, enabling the students to contextualise the digital technologies within different humanities areas, beyond the acquisition of technical skills and knowledge of computational methods and tools usually referred to as the toolbox-based education paradigm. [less ▲]

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See detailEditorial
Cole, Mark David UL

in UFITA - Archiv für Medienrecht und Medienwissenschaft (2021), 85(2021), 3-5

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See detailIntelligent Autonomous Agents and Trust in Virtual Reality
Sun, Ningyuan UL; Botev, Jean UL

in Computers in Human Behavior Reports (2021)

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See detailChronique de droit des marchés financiers
Conac, Pierre-Henri UL

in Revue des Sociétés (2021)

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See detailExplicar los impactos de la globalización en las zonas transfronterizas a través de la calidad de la democracia. Un marco interregional comparativo
Koff, Harlan UL; Mejía Idarraga, Santiago

in Estudios Políticos (2021), 62

Globalisation has significantly affected the ability of States to govern flows. Important questions which have recently emerged in international relations ask: how has globalisation affected border ... [more ▼]

Globalisation has significantly affected the ability of States to govern flows. Important questions which have recently emerged in international relations ask: how has globalisation affected border regions and what explains these impacts? Employing a comparative, cross-regional research design, this article proposes two originalresponses to these questions: first, it questions whether border communities benefit or suffer from globalization and, in doing so, it addresses the impacts of globalization on border communities. Second, an attempt is made to explain these impacts by studying the democratic quality of border integration processes. Thus, globalization is examined as a system in which the benefits are distributed or concentrated according to the quality of the integration processes. [less ▲]

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See detailCase study on augmented reality, digital and physical modelling with mathematical learning disabilities students in an elementary school in Luxemburg
Haas, Ben; Kreis, Yves UL; Lavicza, Zsolt

in International Journal for Technology in Mathematics Education (2021), 28(3), 125-132

This paper reports on a case study of two elementary school students with mathematical learning disabilities (MLD) (ages 10 and 11) using augmented reality (AR), digital and physical modelling in ... [more ▼]

This paper reports on a case study of two elementary school students with mathematical learning disabilities (MLD) (ages 10 and 11) using augmented reality (AR), digital and physical modelling in mathematics class. MLD students worked on modelling geometric shapes (cubes, cuboids, squared pyramids, and octahedrons) and forms (polygons) by combining real-world objects with AR and creating a copy of geometric shapes or missing parts with a 3D printing device. The study focused on the development of process skills and mathematical concepts, tried to identify changes in the visual-spatial memory, and documented the learning behaviour in class. Further, we collected data through task-based interviews with both students. Based on our findings, we present settings and manipulatives which are likely to foster process skills and mathematical concepts in geometry tasks suitable for MLD elementary school students. [less ▲]

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See detailCan perioperative psychological interventions decrease the risk of post-surgical pain and disability? A systematic review and meta-analysis of randomized controlled trials
Nadinda, Putu G; van Ryckeghem, Dimitri UL; Peters, Madelon L

in Pain (2021)

Many patients experience pain after surgery. Psychological factors such as emotion and cognition are shown to be associated with the development of acute and chronic post-surgical pain. Therefore, the ... [more ▼]

Many patients experience pain after surgery. Psychological factors such as emotion and cognition are shown to be associated with the development of acute and chronic post-surgical pain. Therefore, the question arises whether targeting these psychological factors can reduce negative post-surgical outcomes. The aim of the current review is to investigate the efficacy of perioperative psychological interventions in reducing (sub)acute and chronic post-surgical pain and disability in adults. Randomized controlled trials were identified through four databases (Web of Science, PsycINFO, PubMed, and CINAHL). The outcomes of interest were (sub)acute (i.e., within 3 months after surgery) and chronic (> 3 months after surgery) pain and disability. After screening, 21 studies were included in the final analyses. It was found that psychological interventions significantly reduced (sub)acute pain (d = -0.26, 95% CI [-0.48 to -0.04]), and disability (d = -0.43, 95% CI [-0.84 to -0.03]), as well as chronic post-surgical pain (d = -0.33, 95% CI [-0.61 to -0.06]), and disability (d = -0.43, 95% CI [-0.68 to -0.18]). Additionally, interventions delivered after surgery and interventions delivered by a psychologist tended to be more effective than interventions delivered before surgery and interventions delivered by another healthcare provider. Furthermore, the current review points to the need for more research to determine which specific type of intervention may be most beneficial for surgical patients. Finally, the current review identified that research in this domain has concerns regarding bias in missing outcomes data due to withdrawal and drop out. [less ▲]

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See detailDeep Learning to Predict the Feasibility of Priority-Based Ethernet Network Configurations
Mai, Tieu Long UL; Navet, Nicolas UL

in ACM Transactions on Cyber-Physical Systems (2021), 5(4), 126

Machine learning has been recently applied in real-time systems to predict whether Ethernet network configurations are feasible in terms of meeting deadline constraints without executing conventional ... [more ▼]

Machine learning has been recently applied in real-time systems to predict whether Ethernet network configurations are feasible in terms of meeting deadline constraints without executing conventional schedulability analysis. However, the existing prediction techniques require domain expertise to choose the relevant input features and do not perform consistently when topologies or traffic patterns differ significantly from the ones in the training data. To overcome these problems, we propose a Graph Neural Network (GNN) prediction model that synthesizes relevant features directly from the raw data. This deep learning model possesses the ability to exploit relations among flows, links, and queues in switched Ethernet networks, and generalizes to unseen topologies and traffic patterns. We also explore the use of ensembles of GNNs and show that it enhances the robustness of the predictions. An evaluation on heterogeneous testing sets comprising realistic automotive networks, shows that ensembles of 32 GNN models features a prediction accuracy ranging from 79.3% to 90% for Ethernet networks using priorities as the Quality-of-Service mechanism. The use of ensemble models provides a speedup factor ranging from 77 to 1715 compared to schedulability analysis, which allows a far more extensive design space exploration. [less ▲]

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See detailNanopore Single-Molecule Sequencing for Mitochondrial DNA Methylation Analysis: Investigating Parkin-Associated Parkinsonism as a Proof of Concept
Lüth, Theresa; Wasner, Kobi UL; Klein, Christine et al

in Frontiers in Aging Neuroscience (2021)

Objective: To establish a workflow for mitochondrial DNA (mtDNA) CpG methylation using Nanopore whole-genome sequencing and perform first pilot experiments on affected Parkin biallelic mutation carriers ... [more ▼]

Objective: To establish a workflow for mitochondrial DNA (mtDNA) CpG methylation using Nanopore whole-genome sequencing and perform first pilot experiments on affected Parkin biallelic mutation carriers (Parkin-PD) and healthy controls. Background: Mitochondria, including mtDNA, are established key players in Parkinson's disease (PD) pathogenesis. Mutations in Parkin, essential for degradation of damaged mitochondria, cause early-onset PD. However, mtDNA methylation and its implication in PD is understudied. Herein, we establish a workflow using Nanopore sequencing to directly detect mtDNA CpG methylation and compare mtDNA methylation between Parkin-related PD and healthy individuals. Methods: To obtain mtDNA, whole-genome Nanopore sequencing was performed on blood-derived from five Parkin-PD and three control subjects. In addition, induced pluripotent stem cell (iPSC)-derived midbrain neurons from four of these patients with PD and the three control subjects were investigated. The workflow was validated, using methylated and unmethylated 897 bp synthetic DNA samples at different dilution ratios (0, 50, 100% methylation) and mtDNA without methylation. MtDNA CpG methylation frequency (MF) was detected using Nanopolish and Megalodon. Results: Across all blood-derived samples, we obtained a mean coverage of 250.3X (SD ± 80.5X) and across all neuron-derived samples 830X (SD ± 465X) of the mitochondrial genome. We detected overall low-level CpG methylation from the blood-derived DNA (mean MF ± SD = 0.029 ± 0.041) and neuron-derived DNA (mean MF ± SD = 0.019 ± 0.035). Validation of the workflow, using synthetic DNA samples showed that highly methylated DNA molecules were prone to lower Guppy Phred quality scores and thereby more likely to fail Guppy base-calling. CpG methylation in blood- and neuron-derived DNA was significantly lower in Parkin-PD compared to controls (Mann-Whitney U-test p < 0.05). Conclusion: Nanopore sequencing is a useful method to investigate mtDNA methylation architecture, including Guppy-failed reads is of importance when investigating highly methylated sites. We present a mtDNA methylation workflow and suggest methylation variability across different tissues and between Parkin-PD patients and controls as an initial model to investigate. [less ▲]

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See detailA new brain organoid model to study Parkinson’s Disease
Bolognin, Silvia UL; Smits, Lisa UL; Nickels, Sarah Louise UL et al

in Biomedical Science and Engineering (2021)

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See detailDistinct gene-set burden patterns underlie common generalized and focal epilepsies
Koko, Mahmoud; Krause, Roland UL; Sander, Thomas et al

in EBioMedicine (2021), 72

Background Analyses of few gene-sets in epilepsy showed a potential to unravel key disease associations. We set out to investigate the burden of ultra-rare variants (URVs) in a comprehensive range of ... [more ▼]

Background Analyses of few gene-sets in epilepsy showed a potential to unravel key disease associations. We set out to investigate the burden of ultra-rare variants (URVs) in a comprehensive range of biologically informed gene-sets presumed to be implicated in epileptogenesis. Methods The burden of 12 URV types in 92 gene-sets was compared between cases and controls using whole exome sequencing data from individuals of European descent with developmental and epileptic encephalopathies (DEE, n = 1,003), genetic generalized epilepsy (GGE, n = 3,064), or non-acquired focal epilepsy (NAFE, n = 3,522), collected by the Epi25 Collaborative, compared to 3,962 ancestry-matched controls. Findings Missense URVs in highly constrained regions were enriched in neuron-specific and developmental genes, whereas genes not expressed in brain were not affected. GGE featured a higher burden in gene-sets derived from inhibitory vs. excitatory neurons or associated receptors, whereas the opposite was found for NAFE, and DEE featured a burden in both. Top-ranked susceptibility genes from recent genome-wide association studies (GWAS) and gene-sets derived from generalized vs. focal epilepsies revealed specific enrichment patterns of URVs in GGE vs. NAFE. Interpretation Missense URVs affecting highly constrained sites differentially impact genes expressed in inhibitory vs. excitatory pathways in generalized vs. focal epilepsies. The excess of URVs in top-ranked GWAS risk-genes suggests a convergence of rare deleterious and common risk-variants in the pathogenesis of generalized and focal epilepsies. [less ▲]

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See detailUhlmann fidelity and fidelity susceptibility for integrable spin chains at finite temperature: exact results
Białończyk, Michał; Gomez-Ruiz, Fernando Javier; Del Campo Echevarria, Adolfo UL

in New Journal of Physics (2021)

We derive the exact expression for the Uhlmann fidelity between arbitrary thermal Gibbs states of the quantum XY model in a transverse field with finite system size. Using it, we conduct a thorough ... [more ▼]

We derive the exact expression for the Uhlmann fidelity between arbitrary thermal Gibbs states of the quantum XY model in a transverse field with finite system size. Using it, we conduct a thorough analysis of the fidelity susceptibility of thermal states for the Ising model in a transverse field.We compare the exact results with a common approximation that considers only the positive-parity subspace, which is shown to be valid only at high temperatures. The proper inclusion of the odd parity subspace leads to the enhancement of maximal fidelity susceptibility in the intermediate range of temperatures. We show that this enhancement persists in the thermodynamic limit and scales quadratically with the system size. The correct low-temperature behavior is captured by an approximation involving the two lowest many-body energy eigenstates, from which simple expressions are obtained for the thermal susceptibility and specific heat. [less ▲]

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See detailExperimental evaluation of RF waveform designs for Wireless Power Transfer using Software Defined Radio
Gautam, Sumit UL; Kumar, Sumit UL; Chatzinotas, Symeon UL et al

in IEEE Access (2021), 9

The possibility to harvest energy from ambient radio-frequency (RF) sources has intrigued humankind for the past several decades. In this context, there has been a tremendously growing research interest ... [more ▼]

The possibility to harvest energy from ambient radio-frequency (RF) sources has intrigued humankind for the past several decades. In this context, there has been a tremendously growing research interest in the field of wireless power transfer (WPT) using the RF range of the electromagnetic (EM) spectrum. In this paper, we experimentally investigate the aspect of real-time energy harvesting (EH) via different types of waveform designs such as orthogonal frequency division multiplexing (OFDM), square, triangular, sinusoidal, and sawtooth. We make use of a Software Defined Radio (SDR) and a Powercast P21XXCSR-EVB EH module to carry out the experiments on a practical device to assess performance. Specifically, we are interested in obtaining some insights based on the comparison between the aforementioned waveform designs from the perspectives of the separation distance between the USRP and P21XXCSR-EVB EH module, and power emission via USRP. In this vein, we perform additional subsequent experiments after reporting the practical effectiveness of the OFDM waveform, which also follows our intuitive analysis. Correspondingly, we study the effect on WPT with variable USRP transmit power, the separation distance between the USRP and EH antennas, number of OFDM sub-carriers, and multipath setting. As an application of OFDM, the effectiveness of fifth generation-new radio (5G-NR) and long-term evolution (LTE) waveforms are also tested for the WPT mechanism. The demonstration of the EH is provided in terms of the above-mentioned investigation metrics while seeking the best waveform to support WPT. [less ▲]

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See detailTaking the Complex Dynamics of Human–Environment–Technology Systems Seriously: A Case Study in Doctoral Education at the University of Luxembourg
König, Ariane UL; Ravetz, Jerome; Raber, Bo Manuel UL et al

in Frontiers in Sustainability (2021), 2

Our existential sustainability challenges involve human–environment–technology systems that are complex, dynamic and tightly coupled. But at universities, knowledge, in teaching and research, is mostly ... [more ▼]

Our existential sustainability challenges involve human–environment–technology systems that are complex, dynamic and tightly coupled. But at universities, knowledge, in teaching and research, is mostly organized into discrete parcels, the disciplines. These are further divided into the categories of natural sciences, social science and the humanities. This paper addresses the question of how in their training of researchers, universities can equip them to better understand their roles and also to act as change agents. It describes a doctoral school course in transferable skills that is offered across faculties. The unique aim of the course is to provide a space for reflection on different research paradigms and the way they differ in their framing the role of a scientific researcher in pluralist societies that face existential challenges. The course introduces diverse more recent approaches to scientific inquiry that harness the potential of democratizing science in our networked knowledge society, including critical interdisciplinarity, post-normal science, citizen science and transformative sustainability science, that complement normal disciplinary research practices. [less ▲]

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See detailFinite-Alphabet Symbol-Level Multiuser Precoding for Massive MU-MIMO Downlink
Haqiqatnejad, Alireza UL; Kayhan, Farbod; Shahram, ShahbazPanahi et al

in IEEE Transactions on Signal Processing (2021), 69

We propose a finite-alphabet symbol-level precoding technique for massive multiuser multiple-input multiple-output (MU-MIMO) downlink systems which are equipped with finite-resolution digital-to-analog ... [more ▼]

We propose a finite-alphabet symbol-level precoding technique for massive multiuser multiple-input multiple-output (MU-MIMO) downlink systems which are equipped with finite-resolution digital-to-analog converters (DACs) of any precision. Using the idea of constructive interference (CI), we adopt a max-min fair design criterion which aims to maximize the minimum instantaneous received signal-to-noise ratio (SNR) among the user equipments (UEs) while ensuring a CI constraint for each UE under the restriction that the output of the precoder is a vector with finite-alphabet discrete elements. Due to this latter constraint, the design problem is an NP-hard quadratic program with discrete variables, and hence, is difficult to solve. In this paper, we tackle this difficulty by reformulating the problem in several steps into an equivalent continuous-domain biconvex form, including equivalent representations for discrete and binary constraints. Our final biconvex reformulation is obtained via an exact penalty approach and can efficiently be solved using a standard cyclic block coordinate descent algorithm. We evaluate the performance of the proposed finite-alphabet precoding design for DACs with different resolutions, where it is shown that employing low-resolution DACs can lead to higher power efficiencies. In particular, we focus on a setup with one-bit DACs and show through simulation results that compared to the existing schemes, the proposed design can achieve SNR gains of up to 2 dB. We further provide analytic and numerical analyses of complexity and show that our proposed algorithm is computationally efficient as it typically needs only a few tens of iterations to converge. [less ▲]

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See detailMachine learning in mix design of Miscanthus lightweight concrete
Pereira Dias, Patrick; Jayasinghe, Laddu Bhagya; Waldmann, Daniele UL

in Construction and Building Materials (2021)

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See detailBinary blended cement pastes and concrete using gravel wash mud (GWM) powders
Thapa, Vishojit; Waldmann, Daniele UL

in Construction and Building Materials (2021)

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See detailNonlinear three-dimensional anisotropic material model for failure analysis of timber
Eslami, Hooman; Jayasinghe, Laddu Bhagya; Waldmann, Daniele UL

in Engineering Failure Analysis (2021)

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See detailDelta-kick cooling, time-optimal control of scale-invariant dynamics, and shortcuts to adiabaticity assisted by kicks
Dupays, Léonce UL; Spierings, David C.; Steinberg, Aephraim M. et al

in Physical Review Research (2021)

Delta-kick cooling (DKC) is used to compress the momentum distribution of ultracold quantum matter. It combines expansion dynamics with the use of kick pulses, designed via classical methods, that bring ... [more ▼]

Delta-kick cooling (DKC) is used to compress the momentum distribution of ultracold quantum matter. It combines expansion dynamics with the use of kick pulses, designed via classical methods, that bring the system to rest.We introduce an exact approach to DKC for arbitrary scale-invariant dynamics of quantum gases, lifting the original restrictions to free evolution and noninteracting systems, to account for the control of atomic clouds in a time-dependent harmonic trap that can be either repulsive (inverted) or confining. We show that DKC assisted by a repulsive potential outperforms the conventional scheme, and that sudden trap-frequency quenches combined with DKC are equivalent to time-optimal bang-bang protocols.We further show that reverse engineering of the scale-invariant dynamics under smooth trap-frequency modulations can be combined with DKC to introduce a new class of shortcuts to adiabaticity assisted by kicks. [less ▲]

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See detailReview of Adam Crymble: Technology and the Historian. Transformations in the Digital Age
Zaagsma, Gerben UL

in H-Soz-Kult: Kommunikation und Fachinformation für die Geschichtswissenschaften (2021)

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See detailMicrodiversity characterizes prevalent phylogenetic clades in the glacier-fed stream microbiome
Fodelianakis, Styliianos; Busi, Susheel Bhanu UL; Wilmes, Paul UL et al

in ISME Journal (2021)

Glacier-fed streams (GFSs) are extreme and rapidly vanishing ecosystems, and yet they harbor diverse microbial communities. Although our understanding of the GFS microbiome has recently increased, we do ... [more ▼]

Glacier-fed streams (GFSs) are extreme and rapidly vanishing ecosystems, and yet they harbor diverse microbial communities. Although our understanding of the GFS microbiome has recently increased, we do not know which microbial clades are ecologically successful in these ecosystems, nor do we understand potentially underlying mechanisms. Ecologically successful clades should be more prevalent across GFSs compared to other clades, which should be reflected as clade-wise distinctly low phylogenetic turnover. However, methods to assess such patterns are currently missing. Here we developed and applied a novel analytical framework, “phyloscore analysis”, to identify clades with lower spatial phylogenetic turnover than other clades in the sediment microbiome across twenty GFSs in New Zealand. These clades constituted up to 44% and 64% of community α-diversity and abundance, respectively. Furthermore, both their α-diversity and abundance increased as sediment chlorophyll a decreased, corroborating their ecological success in GFS habitats largely devoid of primary production. These clades also contained elevated levels of putative microdiversity than others, which could potentially explain their high prevalence in GFSs. This hitherto unknown microdiversity may be threatened as glaciers shrink, urging towards further genomic and functional exploration of the GFS microbiome. [less ▲]

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See detailNonequilibrium thermodynamics of light-induced reactions
Penocchio, Emanuele UL; Rao, Riccardo; Esposito, Massimiliano UL

in Journal of Chemical Physics (2021), 155

Current formulations of nonequilibrium thermodynamics of open chemical reaction networks only consider chemostats as free-energy sources sustaining nonequilibrium behaviors. Here, we extend the theory to ... [more ▼]

Current formulations of nonequilibrium thermodynamics of open chemical reaction networks only consider chemostats as free-energy sources sustaining nonequilibrium behaviors. Here, we extend the theory to include incoherent light as a source of free energy. We do so by relying on a local equilibrium assumption to derive the chemical potential of photons relative to the system they interact with. This allows us to identify the thermodynamic potential and the thermodynamic forces driving light-reacting chemical systems out-of-equilibrium. We use this framework to treat two paradigmatic photochemical mechanisms describing light-induced unimolecular reactions—namely, the adiabatic and diabatic mechanisms—and highlight the different thermodynamics they lead to. Furthermore, using a thermodynamic coarse-graining procedure, we express our findings in terms of commonly measured experimental quantities, such as quantum yields. [less ▲]

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See detailArtificial intelligence and machine learning: an introduction for orthopaedic surgeons
Ley, Christophe UL; Martin, R. Kyle; Pareek, Ayoosh et al

in Knee Surgery, Sports Traumatology, Arthroscopy (2021)

The application of artificial intelligence (AI) and machine learning to the field of orthopaedic surgery is rapidly increasing. While this represents an important step in the advancement of our specialty ... [more ▼]

The application of artificial intelligence (AI) and machine learning to the field of orthopaedic surgery is rapidly increasing. While this represents an important step in the advancement of our specialty, the concept of AI is rich with statistical jargon and techniques unfamiliar to many clinicians. This knowledge gap may limit the impact and potential of these novel techniques. We aim to narrow this gap in a way that is accessible for all orthopaedic surgeons. With this manuscript, we introduce the concept of AI and machine learning and give examples of how it can impact clinical practice and patient care. [less ▲]

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See detailQKD parameter estimation by two-universal hashing leads to faster convergence to the asymptotic rate
Ostrev, Dimiter UL

in Quantum (2021)

This paper proposes and proves security of a QKD protocol which uses two-universal hashing instead of random sampling to estimate the number of bit flip and phase flip errors. This protocol dramatically ... [more ▼]

This paper proposes and proves security of a QKD protocol which uses two-universal hashing instead of random sampling to estimate the number of bit flip and phase flip errors. This protocol dramatically outperforms previous QKD protocols for small block sizes. More generally, for the two-universal hashing QKD protocol, the difference between asymptotic and finite key rate decreases with the number $n$ of qubits as $cn^{-1}$, where $c$ depends on the security parameter. For comparison, the same difference decreases no faster than $c'n^{-1/3}$ for an optimized protocol that uses random sampling and has the same asymptotic rate, where $c'$ depends on the security parameter and the error rate. [less ▲]

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See detailJoint Transmit Waveform and Receive Filter Design for Dual-Function Radar-Communication Systems
Tsinos, Christos UL; Arora, Aakash UL; Chatzinotas, Symeon UL et al

in IEEE Journal of Selected Topics in Signal Processing (2021), 15(6), 1378-1392

In this paper, the problem of joint transmit waveform and receive filter design for dual-function radar-communication (DFRC) systems is studied. The considered system model involves a multiple antenna ... [more ▼]

In this paper, the problem of joint transmit waveform and receive filter design for dual-function radar-communication (DFRC) systems is studied. The considered system model involves a multiple antenna base station (BS) of a cellular system serving multiple single antenna users on the downlink. Furthermore, the BS simultaneously introduces sensing capabilities in the form of point-like target detection from the reflected return signals in a signal-dependent interference environment. A novel framework based on constrained optimization problems is proposed for the joint design of the transmit waveform and the radar receive filter such that different constraints related to the power amplifiers and the radar waveform are satisfied. In contrast to the existing approaches in the DFRC systems’ literature, the proposed approach does not require the knowledge of a predetermined radar beampattern in order to optimize the performance of the radar part through its approximation. Instead, a beampattern is generated by maximizing the radar receive signal-to-interference ratio (SINR) thus, enabling a more flexible design. Moreover, the radar receive filter processing and its optimization is considered for the first time on DFRC systems, enabling the effective exploitation of the available degrees of freedom in the radar receive array. Efficient algorithmic solutions with guaranteed convergence are developed for the defined constrained nonconvex optimization problems. The effectiveness of the proposed solutions is verified via numerical results. [less ▲]

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See detailChild–Computer Interaction: From a systematic review towards an integrated understanding of interaction design methods for children
Lehnert, Florence Kristin UL; Niess, Jasmin; Lallemand, Carine UL et al

in International Journal of Child - Computer Interaction (2021), 100398

Child–Computer Interaction (CCI) is a steadily growing field that focuses on children as a prominent and emergent user group. For more than twenty years, the Interaction Design for Children (IDC ... [more ▼]

Child–Computer Interaction (CCI) is a steadily growing field that focuses on children as a prominent and emergent user group. For more than twenty years, the Interaction Design for Children (IDC) community has developed, extended, and advanced research and design methods for children’s involvement in designing and evaluating interactive technologies. However, as the CCI field evolves, the need arises for an integrated understanding of interaction design methods currently applied. To that end, we analyzed 272 full papers across a selection of journals and conference venues from 2005 to 2020. Our review contributes to the literature on this topic by (1) examining a holistic child population, including developmentally diverse children and children from 0 to 18 years old, (2) illustrating the interplay of children’s and adults’ roles across different methods, and (3) identifying patterns of triangulation in the methods applied while taking recent ethical debates about children’s involvement in design into account. While we found that most studies were conducted in natural settings, we observed a preference for evaluating interactive artifacts at a single point in time. Method triangulation was applied in two-thirds of the papers, with a preference for qualitative methods. Researchers used triangulation predominantly with respect to mainstream methods that were not specifically developed for child participants, such as user observation combined with semi-structured interviews or activity logging. However, the CCI field employs a wide variety of creative design methods which engage children more actively in the design process by having them take on roles such as informant and design partner. In turn, we see that more passive children’s roles, e.g., user or tester, are more often linked to an expert mindset by the adult. Adults take on a wider spectrum of roles in the design process when addressing specific developmental groups, such as children with autism spectrum disorder. We conclude with a critical discussion about the constraints involved in conducting CCI research and discuss implications that can inform future methodological advances in the field and underlying challenges. [less ▲]

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See detailMachine learning for surgical time prediction
Martinez, Oscar; Martinez Luna, Carol UL; Parra, Carlos et al

in Computer Methods and Programs in Biomedicine (2021)

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See detailApproaches for completing metabolic networks through metabolite damage and repair discovery
Griffith, Corey UL; Walvekar, Adhish UL; Linster, Carole UL

in Current Opinion in Systems Biology (2021), 28

Metabolites are prone to damage, either via enzymatic side reactions, which collectively form the underground metabolism, or via spontaneous chemical reactions. The resulting non-canonical metabolites ... [more ▼]

Metabolites are prone to damage, either via enzymatic side reactions, which collectively form the underground metabolism, or via spontaneous chemical reactions. The resulting non-canonical metabolites that can be toxic, are mended by dedicated “metabolite repair enzymes.” Deficiencies in the latter can cause severe disease in humans, whereas inclusion of repair enzymes in metabolically engineered systems can improve the production yield of value-added chemicals. The metabolite damage and repair loops are typically not yet included in metabolic reconstructions and it is likely that many remain to be discovered. Here, we review strategies and associated challenges for unveiling non-canonical metabolites and metabolite repair enzymes, including systematic approaches based on high-resolution mass spectrometry, metabolome-wide side-activity prediction, as well as high-throughput substrate and phenotypic screens. [less ▲]

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See detailApproaches for completing metabolic networks through metabolite damage and repair discovery
Griffith, Corey UL; Walvekar, Adhish UL; Linster, Carole UL

in Current Opinion in Systems Biology (2021), 28

Metabolites are prone to damage, either via enzymatic side reactions, which collectively form the underground metabolism, or via spontaneous chemical reactions. The resulting non-canonical metabolites ... [more ▼]

Metabolites are prone to damage, either via enzymatic side reactions, which collectively form the underground metabolism, or via spontaneous chemical reactions. The resulting non-canonical metabolites that can be toxic, are mended by dedicated “metabolite repair enzymes.” Deficiencies in the latter can cause severe disease in humans, whereas inclusion of repair enzymes in metabolically engineered systems can improve the production yield of value-added chemicals. The metabolite damage and repair loops are typically not yet included in metabolic reconstructions and it is likely that many remain to be discovered. Here, we review strategies and associated challenges for unveiling non-canonical metabolites and metabolite repair enzymes, including systematic approaches based on high-resolution mass spectrometry, metabolome-wide side-activity prediction, as well as high-throughput substrate and phenotypic screens. [less ▲]

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See detailSingle‑nuclei chromatin profiling of ventral midbrain reveals cell identity transcription factors and cell‑type‑specific gene regulatory variation
Gui, Yujuan; Grzyb, Kamil UL; Thomas, Melanie UL et al

in Epigenetics and Chromatin (2021)

Background: Cell types in ventral midbrain are involved in diseases with variable genetic susceptibility, such as Parkinson’s disease and schizophrenia. Many genetic variants affect regulatory regions and ... [more ▼]

Background: Cell types in ventral midbrain are involved in diseases with variable genetic susceptibility, such as Parkinson’s disease and schizophrenia. Many genetic variants affect regulatory regions and alter gene expression in a cell-type-specific manner depending on the chromatin structure and accessibility. Results: We report 20,658 single-nuclei chromatin accessibility profiles of ventral midbrain from two genetically and phenotypically distinct mouse strains. We distinguish ten cell types based on chromatin profiles and analysis of accessible regions controlling cell identity genes highlights cell-type-specific key transcription factors. Regulatory variation segregating the mouse strains manifests more on transcriptome than chromatin level. However, cell-type-level data reveals changes not captured at tissue level. To discover the scope and cell-type specificity of cis-acting variation in midbrain gene expression, we identify putative regulatory variants and show them to be enriched at differentially expressed loci. Finally, we find TCF7L2 to mediate trans-acting variation selectively in midbrain neurons. Conclusions: Our data set provides an extensive resource to study gene regulation in mesencephalon and provides insights into control of cell identity in the midbrain and identifies cell-type-specific regulatory variation possibly underlying phenotypic and behavioural differences between mouse strains. [less ▲]

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See detailLa cybersecurity come bene pubblico: alcune riflessioni normative a partire dai recenti sviluppi nel diritto UE
Brighi, Raffaella; Chiara, Pier Giorgio UL

in Federalismi.it (2021), 21

The article casts the light on how and to what extent the recent EU legislative developments can uphold the thesis that would identify cybersecurity as a public good, in particular, taking into account ... [more ▼]

The article casts the light on how and to what extent the recent EU legislative developments can uphold the thesis that would identify cybersecurity as a public good, in particular, taking into account systems’ robustness. The doctrine of the public good, which is typically an economic concept, in its normative dimension reveals a framework of shared responsibilities, in view of the common interest in having a satisfactory level of security of the information systems at the basis of our societies. Improving cybersecurity is essential, on the one hand, to trust and benefit from innovation, connectivity and automation; on the other hand, for safeguarding fundamental rights and freedoms, including the rights to privacy and to the protection of personal data, and the freedom of expression and information. Against this background, the new strategy of the European Commission on cybersecurity, the proposal for an NIS 2.0 Directive and, at a lower level of abstraction, the inclusion of minimum cybersecurity requirements for connected devices in the Directives and Regulations of the “New Legislative Framework” (NLF), testify the firm will of the Commission to outline a clear, coherent and inclusive regulatory framework, in order to increase the global level of security within the Union. [less ▲]

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See detailHybrid Active-and-Passive Relaying Model for 6G-IoT Greencom Networks with SWIPT
Gautam, Sumit UL; Solanki, Sourabh UL; Sharma, Shree Krishna UL et al

in Sensors (2021), 21

In order to support a massive number of resource-constrained Internet-of-Things (IoT) devices and machine-type devices, it is crucial to design a future beyond 5G/6G wireless networks in an energy ... [more ▼]

In order to support a massive number of resource-constrained Internet-of-Things (IoT) devices and machine-type devices, it is crucial to design a future beyond 5G/6G wireless networks in an energy-efficient manner while incorporating suitable network coverage expansion methodologies. To this end, this paper proposes a novel two-hop hybrid active-and-passive relaying scheme to facilitate simultaneous wireless information and power transfer (SWIPT) considering both time-switching (TS) and power-splitting (PS) receiver architectures, while dynamically modelling the involved dual-hop time-period (TP) metric. An optimization problem is formulated to jointly optimize the throughput, harvested energy, and transmit power of a SWIPT-enabled system with the proposed hybrid scheme. In this regard, we provide two distinct ways to obtain suitable solutions based on the Lagrange dual technique and Dinkelbach method assisted convex programming, respectively, where both the approaches yield an appreciable solution within polynomial computational time. The experimental results are obtained by directly solving the primal problem using a non-linear optimizer. Our numerical results in terms of weighted utility function show the superior performance of the proposed hybrid scheme over passive repeater-only and active relay-only schemes, while also depicting their individual performance benefits over the corresponding benchmark SWIPT systems with the fixed-TP. [less ▲]

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See detailKerr effect in tilted nodal loop semimetals
Ekström, Carl Johan Ingvar UL; Hasdeo, Eddwi Hesky UL; Farias, Maria Belen UL et al

in Physical Review. B (2021), 104(12), 125411

We investigate the optical activity of tilted nodal loop semimetals. We calculate the full conductivity matrix for a band structure containing a nodal loop with possible tilt in the x−y plane, which ... [more ▼]

We investigate the optical activity of tilted nodal loop semimetals. We calculate the full conductivity matrix for a band structure containing a nodal loop with possible tilt in the x−y plane, which allows us to study the Kerr rotation and ellipticity both for a thin film and a bulk material. We find signatures in the Kerr signal that give direct information about the tilt velocity and direction, the radius of the nodal loop and the internal chemical potential of the system. These findings should serve as guide to understanding optical measurements of nodal loop semimetals and as an additional tool to characterize them. [less ▲]

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See detailEvaluating a location-based game to support citizens' situated reflection on history: a mixed-method approach
Jones, Catherine UL

in International Journal of Cartography (2021), 7

This paper describes the process and findings of a critical evaluation conducted for a custom-made Location based game (LBG) designed to support reflection on social history. We use a mixed-method ... [more ▼]

This paper describes the process and findings of a critical evaluation conducted for a custom-made Location based game (LBG) designed to support reflection on social history. We use a mixed-method protocol to answer the following research questions: “Can a LBG be designed to stimulate situated reflection on social history topics? and “What form and type of reflections can occur when participating in a LBG? Using an innovative approach that took inspiration from the field of museum studies and computer science. We chose a Think-aloud protocol to conduct an evaluation in Valletta, Malta and adapted the Remind study protocol to explore participant experience in Luxembourg. We combined transcripts from both sets of experiments wiith user-generated content to complete a systematic analysis using a predefined set of qualitative codes. We were able to identify that LBG can support reflection on social history topics but the depth of and type of reflection depends on the social history content, the individual locations in the city, and personal connections players are able to make to both. [less ▲]

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See detailWarrior candidates: Do voters value combat experience in postwar elections?
Glaurdic, Josip UL; Lesschaeve, Christophe

in Political Research Quarterly (2021)

Electoral competition in postwar societies is often dominated by war veterans. The question whether voters actually reward candidates’ records of war service, however, remains open. We answer it using a ... [more ▼]

Electoral competition in postwar societies is often dominated by war veterans. The question whether voters actually reward candidates’ records of war service, however, remains open. We answer it using a unique dataset with detailed information on the records of combat service of nearly four thousand candidates in two cycles of parliamentary elections held under proportional representation rules with preferential voting in Croatia. Our analysis shows war veterans’ electoral performance to be conditional on the voters’ communities’ exposure to war violence: combat veterans receive a sizeable electoral bonus in areas whose populations were more exposed to war violence, but are penalized in areas whose populations avoided destruction. This divergence is particularly pronounced for candidates of nationalist rightwing parties, demonstrating the importance of the interaction between lived war experiences and political ideology in postwar societies. [less ▲]

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See detailLuxemburger Geschichte revisited. Überlegungen zu meta- und transnationaler Geschichtsschreibung
Binsfeld, Andrea UL; Dostert, Paul; Kmec, Sonja UL et al

in Hemecht: Zeitschrift für Luxemburger Geschichte (2021), 73(3), 261-264

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See detailLuxemburger Geschichte revisited. Überlegungen zu meta- und transnationaler Geschichtsschreibung
Binsfeld, Andrea UL; Dostert, Paul; Kmec, Sonja UL et al

in Hemecht: Zeitschrift für Luxemburger Geschichte (2021), 73(3), 261-264

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See detailEntered into Force: The 2020 Space Law of Luxembourg
Hofmann, Mahulena UL

in Air and Space Law (2021), 46(4-5), 587-602

In comparison with the broad spectrum of Luxembourg’s activities, the national legal framework allowing for authorizing and supervising activities under Luxembourg’s jurisdiction was narrow. The 1991 Law ... [more ▼]

In comparison with the broad spectrum of Luxembourg’s activities, the national legal framework allowing for authorizing and supervising activities under Luxembourg’s jurisdiction was narrow. The 1991 Law on Electronic Media allowed for the authorization of the SES telecommunication satellites. The 2017 Space Resources Law was adopted speedily to welcome operators in this specific area. A legal basis for other activities was missing – there were no binding provisions enabling domestic authorities to regulate launching of space objects, Earth observation, navigation, or on-orbit activities. The Law of 15 December 2020 on Space Activity fills this gap. From 1 January 2021 onwards, future Luxembourg space operators can apply for an authorization of their space activity in or out of its territory, and the conditions for a successful application are known, as are the price and consequences. [less ▲]

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See detailAdaptive Practice Quizzing in a University Lecture: A Pre-Registered Field Experiment
Heitmann, Svenja; Obergassel, Niklas; Fries, Stefan et al

in Journal of Applied Research in Memory and Cognition (2021)

Providing quiz questions has emerged as a powerful means to support learning. However, it is still unclear whether adaptive practice quizzing will enhance beneficial effects in authentic contexts. To ... [more ▼]

Providing quiz questions has emerged as a powerful means to support learning. However, it is still unclear whether adaptive practice quizzing will enhance beneficial effects in authentic contexts. To address this question, university students (N = 188; n = 155 female) were randomly assigned to employ either adaptive practice quizzing, nonadaptive practice quizzing, or note-taking following three consecutive sessions of a standard psychology university lecture for undergraduate pre-service teachers. In the adaptive practice quizzing condition, quiz questions were adapted to learners’ expertise via cognitive demand ratings, whereas in the non-adaptive condition quiz questions followed a fixed sequence. Students in the adaptive practice quizzing condition outperformed those in the nonadaptive condition after a two-week delay, but not after a one-week delay. Exploratory mediation analyses show that performance on the quiz questions during the learning phase seems to be partly responsible for this effect. [less ▲]

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See detailReduced-Complexity LDPC Decoding for Next-Generation IoT Networks
Asif, Muhammad; Khan, Wali Ullah UL; Afzal, H. M. Rehman et al

in Wireless Communications and Mobile Computing (2021)

Low-density parity-check (LDPC) codes have become the focal choice for next-generation Internet of things (IoT) networks. This correspondence proposes an efficient decoding algorithm, dual min-sum (DMS ... [more ▼]

Low-density parity-check (LDPC) codes have become the focal choice for next-generation Internet of things (IoT) networks. This correspondence proposes an efficient decoding algorithm, dual min-sum (DMS), to estimate the first two minima from a set of variable nodes for check-node update (CNU) operation of min-sum (MS) LDPC decoder. The proposed architecture entirely eliminates the large-sized multiplexing system of sorting-based architecture which results in a prominent decrement in hardware complexity and critical delay. Specifically, the DMS architecture eliminates a large number of comparators and multiplexors while keeping the critical delay equal to the most delay-efficient tree-based architecture. Based on experimental results, if the number of inputs is equal to 64, the proposed architecture saves 69%, 68%, and 52% area over the sorting-based, the tree-based, and the low-complexity tree-based architectures, respectively. Furthermore, the simulation results show that the proposed approach provides an excellent error-correction performance in terms of bit error rate (BER) and block error rate (BLER) over an additive white Gaussian noise (AWGN) channel. [less ▲]

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See detailBorderland Child Heterotopias. A Case Study on the Belgian-German Borderlands
Venken, Machteld UL

in Journal of Borderlands Studies (2021), 36(2), 159-180

This article investigates the capacities of children to participate actively in their lives in the Belgian-German borderlands in the time period between World War I and World War II. The article ... [more ▼]

This article investigates the capacities of children to participate actively in their lives in the Belgian-German borderlands in the time period between World War I and World War II. The article interprets a body of historical sources that has hitherto been left unexplored – namely, borderland child ego documents – with the help of insights from child studies and border studies. These ego documents unfold as borderland child heterotopias. Borderland child heterotopias include material places and creative linguistic loci established by or for those considered in crisis in relation to the rest of society based on their age within or outside child spaces of modernity. The borderland child heterotopias offer a unique gateway to borderland children’s past imaginations for a better world. [less ▲]

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See detailLe droit à la sauce piquante n°24 - Septembre 2021
Hiez, David UL; Laurent, Rémi

in Le droit à la sauce piquante (2021), 24

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See detailLe self-placement : un obstacle au bail-in qui doit être levé
Conac, Pierre-Henri UL

in Revue Banque (2021)

Si la protection des épargnants s’est peu à peu renforcée en Europe, elle demeure insuffisante face au risque de renflouement interne (bail-in) ce qui a incité à contourner la résolution. Afin de rendre ... [more ▼]

Si la protection des épargnants s’est peu à peu renforcée en Europe, elle demeure insuffisante face au risque de renflouement interne (bail-in) ce qui a incité à contourner la résolution. Afin de rendre celle-ci moins effrayante, le législateur européen et la Commission devraient exempter de bail-in les titres détenus par les clients « retail » de la banque en résolution ou en liquidation, vendus selon la technique du « self-placement ». [less ▲]

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See detailRules, Norms and Practices. A Comparative Study Exploring Disposal Practices and Facilities in Northern Europe
Kmec, Sonja UL; Nordh, Helena; House, Danielle et al

in Omega: Journal of Death and Dying (2021), 83(4),

We identify and analyse practices and management regimes around burial and handling of ashes across eight case study towns within six Northern European countries. We analyse management of cemeteries and ... [more ▼]

We identify and analyse practices and management regimes around burial and handling of ashes across eight case study towns within six Northern European countries. We analyse management of cemeteries and crematoria gardens, majority practices and provision for minority communities, including various burial types, cremated remains, the re-use of graves, and costs for interments. Comparative data is drawn from analysis of national and local regulations, interviews with stakeholders, and observations at cemeteries and crematoria gardens. The findings show significant variation in national and local regulations and practices for burial and cremation particularly around the re-use of graves, handling of ashes and costs for grave space and cremation. We identify the opportunities and constraints of these variations in terms of accessibility, diversity and equality; and argue for national directions to avoid unequal treatment within nations. Furthermore, we stress the importance of a liberal and inclusive management of European cemeteries and crematoria gardens. [less ▲]

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