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See detailThe mod 2 cohomology rings of congruence subgroups in the Bianchi groups
Berkove, Ethan; Lakeland, Grant; Rahm, Alexander UL

E-print/Working paper (in press)

We provide new tools for the calculation of the torsion in the cohomology of congruence subgroups in the Bianchi groups : An algorithm for finding particularly useful fundamental domains, and an analysis ... [more ▼]

We provide new tools for the calculation of the torsion in the cohomology of congruence subgroups in the Bianchi groups : An algorithm for finding particularly useful fundamental domains, and an analysis of the equivariant spectral sequence combined with torsion subcomplex reduction. [less ▲]

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Peer Reviewed
See detailEthnocentric preferences and the environment with international trade
Zanaj, Skerdilajda UL

E-print/Working paper (2020)

We define a model of international trade with two countries, two vertically differentiated goods, and heterogenous consumers concerning their willingness to pay for quality. Trade generates two sources of ... [more ▼]

We define a model of international trade with two countries, two vertically differentiated goods, and heterogenous consumers concerning their willingness to pay for quality. Trade generates two sources of pollution: the production of domestic and traded goods, and their transportation between countries. Consumers in both countries manifest home bias which translates into ethnocentric preferences: (i) consumer perceive the quality of the domestic good amplified; and (ii) consumers thrive additional satisfaction when consuming a domestic good rather than a foreign one since only the former can satisfy their sense of place. By contrast, they suffer a psychological penalty when consuming a foreign product. We investigate the role of trade costs and ethnocentric attitude in shaping the equilibrium configuration of the international duopoly. Finally, we uncover the environmental damage from production and from transport in presence of ethnocentrism. [less ▲]

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See detailAttitudes towards Multiculturalism in Luxembourg: Measurement Invariance and Factor Structure of the Multicultural Ideology Scale
Stogianni, Maria UL; Murdock, Elke UL; He, Jia et al

E-print/Working paper (2020)

The present study examined the dimensionality and the measurement invariance of the Multicultural Ideology Scale (MCI; Berry & Kalin, 1995), and mean differences across different cultural groups within ... [more ▼]

The present study examined the dimensionality and the measurement invariance of the Multicultural Ideology Scale (MCI; Berry & Kalin, 1995), and mean differences across different cultural groups within the multilingual, multicultural context of Luxembourg. With 47% of the citizens being non-nationals, minority and majority are increasingly difficult to define and Luxembourg becomes a unique context to study attitudes towards diversity. Our sample included 1488 participants from diverse ethnic backgrounds who completed the survey in German, French or English. In contrast to previous findings, our analyses revealed a two-dimensional structure, distinguishing between positive and negative attitudes towards multiculturalism. The factor structure was partially invariant across ethnocultural groups: Configural and metric invariance were established across natives and non-natives, scalar invariance only across gender groups. Natives and male participants reported more negative attitudes towards multiculturalism. We discuss the importance of assessing measurement invariance and provide recommendations to improve the assessment of psychological multiculturalism. [less ▲]

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See detailPriLock:Citizen-protecting distributed epidemic tracing
Esteves-Verissimo, Paulo UL; Decouchant, Jérémie UL; Volp, Marcus UL et al

E-print/Working paper (2020)

Contact tracing is an important instrument for national health services to fight epidemics. As part of the COVID-19 situation, many proposals have been made for scaling up contract tracing capacities with ... [more ▼]

Contact tracing is an important instrument for national health services to fight epidemics. As part of the COVID-19 situation, many proposals have been made for scaling up contract tracing capacities with the help of smartphone applications, an important but highly critical endeavor due to the privacy risks involved in such solutions. Extending our previously expressed concern, we clearly articulate in this article, the functional and non-functional requirements that any solution has to meet, when striving to serve, not mere collections of individuals, but the whole of a nation, as required in face of such potentially dangerous epidemics. We present a critical information infrastructure, PriLock, a fully-open preliminary architecture proposal and design draft for privacy preserving contact tracing, which we believe can be constructed in a way to fulfill the former requirements. Our architecture leverages the existing regulated mobile communication infrastructure and builds upon the concept of "checks and balances", requiring a majority of independent players to agree to effect any operation on it, thus preventing abuse of the highly sensitive information that must be collected and processed for efficient contact tracing. This is enforced with a largely decentralised layout and highly resilient state-of-the-art technology, which we explain in the paper, finishing by giving a security, dependability and resilience analysis, showing how it meets the defined requirements, even while the infrastructure is under attack. [less ▲]

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See detailBehind the Last Line of Defense -- Surviving SoC Faults and Intrusions
Pinto Gouveia, Ines UL; Volp, Marcus UL; Esteves-Verissimo, Paulo UL

E-print/Working paper (2020)

Today, leveraging the enormous modular power, diversity and flexibility of manycore systems-on-a-chip (SoCs) requires careful orchestration of complex resources, a task left to low-level software, e.g ... [more ▼]

Today, leveraging the enormous modular power, diversity and flexibility of manycore systems-on-a-chip (SoCs) requires careful orchestration of complex resources, a task left to low-level software, e.g. hypervisors. In current architectures, this software forms a single point of failure and worthwhile target for attacks: once compromised, adversaries gain access to all information and full control over the platform and the environment it controls. This paper proposes Midir, an enhanced manycore architecture, effecting a paradigm shift from SoCs to distributed SoCs. Midir changes the way platform resources are controlled, by retrofitting tile-based fault containment through well known mechanisms, while securing low-overhead quorum-based consensus on all critical operations, in particular privilege management and, thus, management of containment domains. Allowing versatile redundancy management, Midir promotes resilience for all software levels, including at low level. We explain this architecture, its associated algorithms and hardware mechanisms and show, for the example of a Byzantine fault tolerant microhypervisor, that it outperforms the highly efficient MinBFT by one order of magnitude. [less ▲]

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See detailBoîte à outils pour la formation des enseignants
Scheuer, Claude UL; Heck, Sandra UL

E-print/Working paper (2020)

Dans le cadre du projet BMC-EU (Compétences motrices de base en Europe), une boîte à outils pour la formation des enseignants reprenant le concept de formation ainsi qu’un manuel d'utilisation (BMC-EU ... [more ▼]

Dans le cadre du projet BMC-EU (Compétences motrices de base en Europe), une boîte à outils pour la formation des enseignants reprenant le concept de formation ainsi qu’un manuel d'utilisation (BMC-EU production intellectuelle 4) a été développée afin de soutenir la mise en œuvre de la formation aux tests MOBAK (boîte à outils pour l’enseignant-support théorique) la base du concept de compétences motrices de base (BMC-EU production intellectuelle 3 ; Scheuer & Heck, 2020). L'objectif de cette boîte à outils de soutien est d'être mis en œuvre principalement au niveau des cours réguliers d'éducation physique pour aider les enseignants d’éducation physique à adapter leurs contenus et leurs méthodes d'enseignement. La boîte à outils pour la formation des enseignants présente les éléments à mettre en œuvre lors de formations d'enseignants. Celles-ci sont structurées en une partie théorique et une partie pratique. Dans un premier temps, les enseignants sont familiarisés avec le concept MOBAK, la mesure, la procédure de test, le traitement des données et l’évaluation ainsi qu'avec l'interprétation des résultats du test. Dans une deuxième partie, ils apprennent à passer du diagnostic des compétences motrices de base des élèves et des forces et faiblesses identifiées dans l'évaluation à des interventions concrètes en utilisant le cadre de soutien MOBAK et les documents qui l'accompagnent sous la forme d'un support théorique (boîte à outils pour l’enseignant), prêt à être mis en œuvre dans des situations éducatives concrètes pour soutenir les élèves ayant des besoins supplémentaires en compétences motrices de base. Étant donné que la boîte à outils pour la formation des enseignants vise à soutenir et à faciliter la mise en œuvre de la formation théorique des enseignants de soutien modulaire pour les enseignants (Scheuer et Heck, 2020), il sera fait référence au concept et au construit des tests MOBAK (Herrmann, 2018), et au manuel de test MOBAK tout au long de ce document. [less ▲]

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See detailKit modular de ferramentas para suporte aos professores
Scheuer, Claude UL; Heck, Sandra UL

E-print/Working paper (2020)

No quadro do projeto BMC-EU (Competências motoras básicas na Europa), foi desenvolvida um kit modular de ferramentas de suporte para os professores para o desenvolvimento das competências motoras básicas ... [more ▼]

No quadro do projeto BMC-EU (Competências motoras básicas na Europa), foi desenvolvida um kit modular de ferramentas de suporte para os professores para o desenvolvimento das competências motoras básicas, baseado nos resultados da colheita de dados realizada na fase 1 do projeto, como parte do seu output intelectual 3. O objetivo deste kit de ferramentas é ser implementado principalmente ao nível das aulas regulares de Educação Física, para apoiar as decisões dos professores em relação ao conteúdo e aos métodos no ensino de Educação Física. Numa primeira etapa, a estrutura de suporte foi desenvolvida para permitir avaliar e realizar o diagnóstico das competências motoras básicas dos alunos nos seus pontos fortes e fracos, e apoiar intervenções concretas. Como base dessa estrutura, foram desenvolvidos folhetos de suporte sob a forma de um kit modular de ferramentas de suporte, prontos para serem implementados em situações educacionais concretas, para apoiar o desenvolvimento de algumas competências básicas dos alunos. O kit modular de ferramentas de suporte inclui as diretrizes para a interpretação dos resultados dos testes MOBAK (Motorische Basiskompetenzen; expressão alemã para competências motoras básicas), que são a estrutura de suporte do MOBAK, um glossário, bem como o kit modular de ferramentas de suporte com materiais para professores de Educação Física sob a forma de cartões com a descrição das tarefas do forma de MOBAK e de cartões de atividade MOBAK baseados em princípios da variação e de uma abordagem por competências. [less ▲]

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See detailToolkit voor de brede motorische ontwikkeling
Scheuer, Claude UL; Heck, Sandra UL

E-print/Working paper (2020)

In het kader van het BMC-EU-project (Basismotorische competentie in Europa) is een toolkit voor de training van docenten en een toolkit voor de brede motorische ontwikkeling ontwikkeld. Dit is ontwikkeld ... [more ▼]

In het kader van het BMC-EU-project (Basismotorische competentie in Europa) is een toolkit voor de training van docenten en een toolkit voor de brede motorische ontwikkeling ontwikkeld. Dit is ontwikkeld op basis van het concept basismotorische competenties en de resultaten van de gegevensverzameling in fase 1 van het project als onderdeel van intellectuele output 3. Het doel van deze toolkit is om de inhoud en methoden van de reguliere lessen lichamelijke opvoeding aan te passen aan de (motorische) behoeften van de kinderen. In een eerste stap is het hulpaanbod ontwikkeld. Dit is ontwikkeld op basis van de diagnose van de motorische basiscompetenties van de kinderen en de sterke en zwakke punten die bij de beoordeling zijn geïdentificeerd. Dit vormde het raamwerk voor de ondersteunende hand-outs in deze toolkit. De toolkit kan direct geïmplementeerd worden in concrete onderwijssituaties. Kinderen met aanvullende behoeften in basismotorische competenties kunnen hiermee worden ondersteund. De toolkit bevat verschillende onderdelen: - Richtlijnen voor de interpretatie van MOBAK-testresultaten (Motorische Basiskompetenzen; Duits voor basismotorische competenties). - De MOBAK-toolkit. - Een verklarende woordenlijst. - De modulaire supporttoolkit met materiaal voor leraren lichamelijke opvoeding in de vorm van MOBAK activiteiten-kaarten. - MOBAK-activiteitenkaarten gebaseerd op variatieprincipes en op een competentiegerichte aanpak. [less ▲]

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See detailΕργαλειοθήκη κατάρτισης για εκπαιδευτικούς
Scheuer, Claude UL; Heck, Sandra UL

E-print/Working paper (2020)

Στο πλαίσιο του έργου BMC-EU (Βασικές Κινητικές Δεξιότητες στην Ευρώπη), αναπτύχθηκε μία εργαλειοθήκη κατάρτισης για εκπαιδευτικούς, αποτελούμενη από τη γενική πρακτική ιδέα και ένα συνοδευτικό εγχειρίδιο ... [more ▼]

Στο πλαίσιο του έργου BMC-EU (Βασικές Κινητικές Δεξιότητες στην Ευρώπη), αναπτύχθηκε μία εργαλειοθήκη κατάρτισης για εκπαιδευτικούς, αποτελούμενη από τη γενική πρακτική ιδέα και ένα συνοδευτικό εγχειρίδιο χρήστη (BMC-EU πνευματική παραγωγή 4), για να υποστηρίξει την εφαρμογή της υποστηρικτικής εργαλειοθήκης με βάση την έννοια των βασικών κινητικών δεξιοτήτων (BMC-EU πνευματική παραγωγή 3; Scheuer & Heck, 2020). Ο σκοπός της εργαλειοθήκης αυτής είναι να εφαρμοστεί στα μαθήματα φυσικής αγωγής, ώστε να προσαρμοστούν κατάλληλα τόσο το περιεχόμενο όσο και οι μέθοδοι διδασκαλίας της φυσικής αγωγής. Η εργαλειοθήκη κατάρτισης για εκπαιδευτικούς περιέχει υλικό για τη δημιουργία πρακτικών προγραμμάτων για εκπαιδευτικούς δομημένα τόσο σε θεωρητικό, όσο και πρακτικό επίπεδο. Αρχικά, οι εκπαιδευτικοί εξοικειώνονται με την έννοια του ΜΟΒΑΚ, τις μετρήσεις, τη διαδικασία της εξέτασης, την επεξεργασία των δεδομένων και την αξιολόγηση, καθώς και με την ερμηνεία των αποτελεσμάτων. Στη συνέχεια, μαθαίνουν πώς να μεταβούν από τη διάγνωση των βασικών κινητικών δεξιοτήτων και τον εντοπισμό των αντίστοιχων ικανοτήτων των μαθητών, στον σχεδιασμό και την υλοποίηση συγκεκριμένων παρεμβάσεων με τη χρήση του υποστηρικτικού πλαισίου ΜΟΒΑΚ και των συνοδευτικών υποστηρικτικών φυλλαδίων, που είναι έτοιμα προς εφαρμογή σε συγκεκριμένες εκπαιδευτικές συνθήκες για την υποστήριξη μαθητών με πρόσθετες ανάγκες στις βασικές κινητικές δεξιότητες. Η εργαλειοθήκη κατάρτισης για εκπαιδευτικούς έχει ως σκοπό να υποστηρίξει και να διευκολύνει την εφαρμογή της Υποστηρικτικής εργαλειοθήκης για εκπαιδευτικούς (Scheuer & Heck, 2020), που βασίζεται στην έννοια και τις μετρήσεις ΜΟΒΑΚ (Herrmann, 2018). [less ▲]

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See detailFerramenta de apoio à Formação de Professores
Scheuer, Claude UL; Heck, Sandra UL

E-print/Working paper (2020)

No enquadramento do projeto BMC-EU (Competências motoras básicas na Europa), a ferramenta para a formação de professores consistindo num conceito de formação de professores juntamente com um manual de ... [more ▼]

No enquadramento do projeto BMC-EU (Competências motoras básicas na Europa), a ferramenta para a formação de professores consistindo num conceito de formação de professores juntamente com um manual de utilização (BMC-EU intellectual output 4) foi desenvolvido de modo a apoiar a implementação do kit modular de ferramentas para suporte aos professores considerando o conceito de competências motoras básicas (BMC-EU intellectual output 3; Scheuer & Heck, 2020). O objetivo deste kit de ferramentas de suporte é ser implementado principalmente ao nível da educação física regular para iniciar adaptações relativas ao conteúdo e métodos na instrução da educação física. A ferramenta de apoio à formação de professores contém materiais para implementar a formação de professores estruturada, com uma parte teórica e outra prática. Num primeiro passo, os professores estão familiarizados com o conceito MOBAK, medição, procedimentos do teste, tratamento dos dados e avaliação assim como com a interpretação dos resultados do teste. Numa segunda parte eles aprendem como diagnosticar as competências motoras básicas dos alunos e as forças e fraquezas identificadas na avaliação para concretizar intervenções usando o quadro de referência de suporte MOBAK e as fichas que acompanham o Kit de suporte, prontos para serem implementados em situações educativas concretas para apoiar estudantes com necessidades acrescidas nas competências motoras básicas. Como a ferramenta para a formação de professores visa apoiar e facilitar a implementação do Kit modular de ferramentas para suporte aos professores (Scheuer & Heck, 2020) baseado no conceito e medição do MOBAK (Herrmann, 2018), ao longo deste manual são fornecidas referências para suportar o kit de apoio e o manual do teste MOBAK . [less ▲]

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See detailMokytojų rengimo priemonė
Scheuer, Claude UL; Heck, Sandra UL

E-print/Working paper (2020)

Vykdant BMC-EU projektą "Basic motor competencies in Europe" buvo sukurta mokytojų rengimo priemonė, susidedanti iš mokytojų rengimo sampratos ir vartotojo vadovo (BMC-EU intelektinės veiklos rezultatas ... [more ▼]

Vykdant BMC-EU projektą "Basic motor competencies in Europe" buvo sukurta mokytojų rengimo priemonė, susidedanti iš mokytojų rengimo sampratos ir vartotojo vadovo (BMC-EU intelektinės veiklos rezultatas Nr. 4), kurios tikslas - remiantis motorinių kompetencijų koncepcija padėti įgyvendinti modulinę palaikymo priemonę (BMC-EU intelektinės veiklos rezultatas Nr. 3; Scheuer ir Heck, 2020). Palaikymo priemonė skirta įprastoms kūno kultūros pamokoms, kurių metu skatinami turinio ir metodų pokyčiai ir jų taikymai. Mokytojų rengimo priemonėje pateikiama teorinė ir praktinė medžiaga. Pirmiausia mokytojai supažindinami su MOBAK koncepcija, matavimais, testavimo procedūra, duomenų apdorojimu ir vertinimu bei rezultatų aiškinimu. Antroje dalyje paaiškinama, kaip turimas žinias apie pagrindines moksleivių motorines kompetencijas ir vertinant išryškėjusias jų stipriąsias bei silpnąsias puses panaudoti praktiškai taikant MOBAK paramos sistemą ir kitą pagalbinę medžiagą konkrečiose mokymo situacijose atsižvelgiant į moksleivių poreikius ir pagrindines motorines kompetencijas. Kadangi mokytojų rengimo priemone siekiama palengvinti modulinės palaikymo priemonės mokytojams (Scheuer & Heck, 2020) įgyvendinimą remiantis MOBAK koncepcija ir matavimais (Herrmann, 2018), leidinyje dažnai mnima paramos sistema ir MOBAK vadovas. [less ▲]

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See detailVzorová sada podpůrných nástrojů pro učitele
Scheuer, Claude UL; Heck, Sandra UL

E-print/Working paper (2020)

V rámci projektu BMC-EU (Základní pohybové kompetence v Evropě) byl na základě koncepce základních pohybových kompetencí a výsledků sběru dat vytvořen rámec podpory a vzorová sada nástrojů (výsledek první ... [more ▼]

V rámci projektu BMC-EU (Základní pohybové kompetence v Evropě) byl na základě koncepce základních pohybových kompetencí a výsledků sběru dat vytvořen rámec podpory a vzorová sada nástrojů (výsledek první fáze projektu – intelektuální výstup 3). Účelem této sady je nabídnout variabilní přístup k metodice tělesné výchovy. V první fázi projektu byl vytvořen podpůrný rámec pro diagnostiku základních pohybových kompetencí žáků, jejich silných a slabých stránek z pohledu základních pohybových způsobilostí. Na základě tohoto rámce byly vyvinuty podklady ve formě vzorové podpůrné sady (didaktických) materiálů, připravených k implementaci v konkrétních vzdělávacích situacích, jejichž účelem je rozvoj základních pohybových kompetencí diagnostikovaných žáků. Vzorová podpůrná sada nástrojů obsahuje pokyny pro interpretaci výsledků testů MOBAK (Motorische Basiskompetenzen), podpůrný rámec MOBAK, glosář a vzorovou podpůrnou sadu nástrojů s materiály pro učitele tělesné výchovy ve formě karet MOBAK. Karty MOBAK popisují činnosti a aktivity dle principů variace (rozličnosti podnětů) a jsou založeny na přístupu orientovaném na kompetence. [less ▲]

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See detailManuale di formazione per gli insegnanti
Scheuer, Claude UL; Heck, Sandra UL

E-print/Working paper (2020)

Nell’ambito del progetto BMC-EU (Competenze motorie di base in Europa), è stato sviluppato un ulteriore documento utile alla formazione degli insegnanti, che consiste in un manuale di formazione (output ... [more ▼]

Nell’ambito del progetto BMC-EU (Competenze motorie di base in Europa), è stato sviluppato un ulteriore documento utile alla formazione degli insegnanti, che consiste in un manuale di formazione (output intellettuale BMC-EU 4), al fine di implementare il manuale modulare riguardante le competenze motorie di base (produzione intellettuale BMC-EU 3; Scheuer & Heck, 2020). Lo scopo di questo manuale è quello di ampliare i contenuti delle lezioni curriculari di educazione fisica, per proporre gli adattamenti riguardanti le attività ed i metodi. Il manuale contiene i materiali per implementare il processo di formazione degli insegnanti ed è strutturato in una parte teorica e una pratica. In una prima parte, gli insegnanti acquisiscono familiarità con la struttura del MOBAK, la misurazione, l’attuazione delle prove, l’elaborazione e e la valutazione dei dati, nonché con l'interpretazione dei risultati delle prove. In una seconda parte, imparano ad acquisire informazioni sulle competenze motorie di base degli allievi e sui punti di forza e di debolezza identificati nella valutazione. Inoltre, mediante proposte operative presenti nel manuale modulare del MOBAK e negli allegati, è possibile implementare i contesti di apprendimento per sostenere gli allievi con bisogni educativi speciali nelle competenze motorie di base. Il presente manuale per la formazione degli insegnanti è finalizzato a sostenere ed integrare il manuale modulare (Scheuer & Heck, 2020), basato sulla struttura e sui livelli del MOBAK (Herrmann, 2018). [less ▲]

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See detailToolkit für die Fortbildung von Sportlehrkräften
Scheuer, Claude UL; Heck, Sandra UL

E-print/Working paper (2020)

Im Rahmen des BMC-EU Projekts (Basic Motor Competencies in Europe) wurde ein Toolkit für die Fortbildung von Sportlehrkräften entwickelt, welches aus einem Fortbildungskonzept inklusive eines Handbuchs ... [more ▼]

Im Rahmen des BMC-EU Projekts (Basic Motor Competencies in Europe) wurde ein Toolkit für die Fortbildung von Sportlehrkräften entwickelt, welches aus einem Fortbildungskonzept inklusive eines Handbuchs (BMC-EU intellectual output 4) besteht. Die Entwicklung dieses Fortbildungskonzepts soll dazu beitragen, dass das modulare Support Toolkit auf der Basis des Konzepts der motorischen Basiskompetenzen (BMC-EU intellectual output 3; Scheuer & Heck, 2020) eingesetzt wird. Das Ziel dieses Support Toolkits ist hauptsächlich der Einsatz auf der Ebene des regulären Sportunterrichts um die Anpassungen, welche den Inhalt und die Methoden des Unterrichtens betreffen, voranzutreiben. Das Toolkit für die Fortbildung von Lehrkräften beinhaltet Materialen, die für die Durchführung einer strukturierten Lehrerfortbildung sowohl im theoretischen als auch im praktischen Teil benötigt werden. Im ersten Schritt werden die Lehrkräfte mit dem MOBAK Konzept, der Datenerhebung, der Testdurchführung, der Datenverarbeitung und –evaluation sowie mit der Interpretation der Testergebnisse vertraut gemacht. Im zweiten Schritt lernen die Lehrkräfte wie sie auf die Stärken und Schwächen ihrer Schülerinnen und Schüler, welche die Ergebnisse aus den Tests zu den motorischen Basiskompetenzen zeigen, fördern können, indem sie das MOBAK Support Toolkit verwenden. Dieses Toolkit kann direkt in konkrete Unterrichtsszenarien eingesetzt werden, um die Schülerinnen und Schüler mit zusätzlichem Förderbedarf in den motorischen Kompetenzen zu unterstützen. Da das Toolkit für die Fortbildung von Lehrkräfte darauf abzielt, die Durchführung des modularen Support Toolkits für Lehrkräfte (Scheuer & Heck, 2020) basierend auf dem MOBAK Konzept (Herrmann, 2018) zu unterstützen und zu ermöglichen, wird in diesem Dokument immer wieder auf das Support Toolkit und das MOBAK Testmanual verwiesen. [less ▲]

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See detailSada nástrojů pro školení učitelů
Scheuer, Claude UL; Heck, Sandra UL

E-print/Working paper (2020)

V rámci projektu BMC-EU (Základní pohybové kompetence v Evropě) byla vyvinuta sada nástrojů pro školení učitelů, skládající se z koncepce školení učitelů a doprovodné uživatelské příručky (intelektuální ... [more ▼]

V rámci projektu BMC-EU (Základní pohybové kompetence v Evropě) byla vyvinuta sada nástrojů pro školení učitelů, skládající se z koncepce školení učitelů a doprovodné uživatelské příručky (intelektuální výstup BMC-EU 4) za účelem podpory implementace modulární podpůrné sady nástrojů na základě konceptu základních pohybových kompetencí (intelektuální výstup BMC-EU 3; Scheuer & Heck, 2020). Cílem této podpůrné sady nástrojů je zavedení do praxe především na úrovni pravidelných hodin tělesné výchovy tak, aby bylo možno začít s přizpůsobováním obsahu a metod výuky tělesné výchovy. Sada nástrojů pro školení učitelů obsahuje materiály pro realizaci školení rozdělené do teoretické a praktické části. V první části jsou učitelé seznámeni s konceptem MOBAK, měřením, testovacím postupem, zpracováním a vyhodnocováním dat a s interpretací výsledků testů. Ve druhé části se naučí, jak dospět od diagnostiky základních pohybových kompetencí studentů a od silných a slabých stránek identifikovaných při hodnocení k tomu, jak konkrétně zasáhnout pomocí podpůrného rámce MOBAK a doprovodných podpůrných materiálů ve formě modulární podpůrné sady nástrojů, která je připravena k zavádění do praxe v konkrétních vzdělávacích situacích za účelem podpory studentů s dalšími potřebami v základních pohybových kompetencích. Vzhledem k tomu, že sada nástrojů pro školení učitelů má za cíl podporovat a usnadňovat implementaci Modulární podpůrné sady pro učitele (Scheuer & Heck, 2020) založenou na konceptu a měření MOBAK (Herrmann, 2018), v celém tomto dokumentu se na podpůrnou sadu nástrojů a na testovací příručku MOBAK odkazuje. [less ▲]

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See detailToolkit voor de training van docenten
Scheuer, Claude UL; Heck, Sandra UL

E-print/Working paper (2020)

In het kader van het BMC-EU project (Basismotorische competenties in Europa) heeft men op basis van het concept van basismotorische competenties (BMC-EU intellectuele output), een toolkit voor de training ... [more ▼]

In het kader van het BMC-EU project (Basismotorische competenties in Europa) heeft men op basis van het concept van basismotorische competenties (BMC-EU intellectuele output), een toolkit voor de training van docenten ontwikkeld met daarbij een bijbehorende gebruikershandleiding. Het doel van deze toolkit is voornamelijk om op het niveau van de reguliere lessen lichamelijke opvoeding aanpassingen te initiëren die van toepassing zijn op de inhoud en methoden in de lichamelijke opvoeding. De training voor docenten is opgedeeld in een praktisch en theoretisch deel. Allereerst worden leraren vertrouwd gemaakt met het MOBAK concept, de meting, testprocedure, de gegevensverwerking en evaluatie, evenals met de interpretatie van de testresultaten. In een tweede deel leren ze hoe ze van de diagnose van de basismotorische competenties van studenten en de sterke en zwakke punten die bij de beoordeling zijn geïdentificeerd, kunnen komen tot concrete interventies. Dit kan door het MOBAK kader en de bijbehorende hand-outs te gebruiken in de vorm van een modulaire ondersteunende toolkit. Deze toolkit kan ingezet worden in concrete onderwijssituaties om kinderen met aanvullende behoeften in basismotorische competenties te ondersteunen. Aangezien de training voor docenten de uitvoering van de toolkit voor de brede motorische ontwikkeling (Scheuer & Heck, 2020), gebaseerd op het MOBAK-concept en meting (Herrmann, 2018), wil ondersteunen en vergemakkelijken, wordt in dit document verwezen naar de ondersteunende toolkit en de MOBAK-testhandleiding. [less ▲]

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See detailTeacher training toolkit
Scheuer, Claude UL; Heck, Sandra UL

E-print/Working paper (2020)

In the frame of the BMC-EU project (Basic motor competencies in Europe), a teacher training toolkit consisting of a teacher training concept with an accompanying user manual (BMC-EU intellectual output 4 ... [more ▼]

In the frame of the BMC-EU project (Basic motor competencies in Europe), a teacher training toolkit consisting of a teacher training concept with an accompanying user manual (BMC-EU intellectual output 4) was developed in order to support the implementation of the modular support toolkit on the basis of the concept of basic motor competences (BMC-EU intellectual output 3; Scheuer & Heck, 2020). The aim of this support toolkit is to be implemented mainly at the level of regular physical education lessons to initiate adaptations regarding the content and methods in physical education instruction. The teacher training toolkit contains materials to implement teacher trainings structured in a theoretical and a practical part. In a first step, teachers are familiarized with the MOBAK concept, measurement, test procedure, data procession and evaluation as well as with the interpretation of test results. In a second part, they learn how to get from the diagnosis of the students’ basic motor competencies and the strengths and weaknesses identified in the assessment to concrete interventions by using the MOBAK support framework and the accompanying supportive handouts in form of a modular support toolkit, ready to be implemented in concrete educational situations to support students with additional needs in basic motor competencies. As the teacher training toolkit aims to support and facilitate the implementation of the Modular support toolkit for teachers (Scheuer & Heck, 2020) based on the MOBAK concept and measurement (Herrmann, 2018), reference to the support toolkit and the MOBAK Test manual is given throughout this document [less ▲]

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See detailNástroj pre školenie učiteľov
Scheuer, Claude UL; Heck, Sandra UL

E-print/Working paper (2020)

V rámci projektu BMC-EU (Základné pohybové kompetencie v Európe) bol vytvorený súbor nástrojov odbornej prípravy učiteľov pozostávajúci z koncepcie odbornej prípravy učiteľov so sprievodným návodom na ... [more ▼]

V rámci projektu BMC-EU (Základné pohybové kompetencie v Európe) bol vytvorený súbor nástrojov odbornej prípravy učiteľov pozostávajúci z koncepcie odbornej prípravy učiteľov so sprievodným návodom na použitie (intelektuálny výstup BMC-EU 4), s cieľom podporiť využitie podporného metodického materiálu na základe koncepcie základných pohybových kompetencií (intelektuálny výstup BMC-EU 3; Scheuer & Heck, 2020). Cieľom tohto podporného materiálu je iniciovať na úrovni pravidelných hodín telesnej a športovej výchovy úpravy týkajúce sa obsahu a metód výučby telesnej a športovej výchovy. Nástroj pre školenie učiteľov obsahuje materiály na realizáciu školení učiteľov štruktúrovaných v teoretickej a praktickej časti. V prvom kroku sú učitelia oboznámení s koncepciou MOBAK, meraním, testovacím postupom, spracovaním a vyhodnotením údajov, ako aj s interpretáciou výsledkov testov. V druhej časti sa naučia, ako získať informácie z diagnostiky základných pohybových kompetencií žiakov a ich silných a slabých stránok identifikovaných pri hodnotení. Tiež sa naučia pracovať s pomocou podporného rámca MOBAK a sprievodných podporných nástrojov vo forme podpornej metodickej príručky, pripravenej na implementáciu v konkrétnych vzdelávacích situáciách na podporu žiakov s ďalšími potrebami v základných pohybových kompetenciách. Keďže cieľom súboru nástrojov prípravy učiteľov je podporiť a uľahčiť implementáciu metodickej príručky pre učiteľov (Scheuer & Heck, 2020) založenej na koncepte a meraní MOBAK (Herrmann, 2018), odkaz na podpornú metodickú príručku MOBAK je uvedený v tomto dokumente. [less ▲]

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Peer Reviewed
See detailPrimary and recurrent glioma patient-derived orthotopic xenografts (PDOX) represent relevant patient avatars for precision medicine
Golebiewska, Anna UL; Hau, Ann-Christin; Oudin, Anais et al

E-print/Working paper (2020)

Patient-derived cancer models are essential tools for studying tumor biology and preclinical interventions. Here, we show that glioma patient-derived orthotopic xenografts (PDOXs) enable long-term ... [more ▼]

Patient-derived cancer models are essential tools for studying tumor biology and preclinical interventions. Here, we show that glioma patient-derived orthotopic xenografts (PDOXs) enable long-term propagation of patient tumors and represent clinically relevant patient avatars. We created a large collection of PDOXs from primary and recurrent gliomas with and without mutations in IDH1, which retained histopathological, genetic, epigenetic and transcriptomic features of patient tumors with no mouse-specific clonal evolution. Longitudinal PDOX models recapitulate the limited genetic evolution of gliomas observed in patient tumors following treatment. PDOX-derived standardized tumor organoid cultures enabled assessment of drug responses, which were validated in mice. PDOXs showed clinically relevant responses to Temozolomide and to targeted treatments such as EGFR and CDK4/6 inhibitors in (epi)genetically defined groups, according to MGMT promoter and EGFR/CDK status respectively. Dianhydrogalactitol, a bifunctional alkylating agent, showed promising potential against glioblastoma. Our study underlines the clinical relevance of glioma PDOX models for translational research and personalized treatment studies. [less ▲]

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See detailBoîte à outil pour l'enseignant - Support théorique
Scheuer, Claude UL; Heck, Sandra UL

E-print/Working paper (2020)

Un cadre théorique de soutien et une boite à outil pédagogique ont été développés dans le cadre du projet BMC-EU (Compétences motrices de base en Europe). Ces documents ont été conçus en tenant compte du ... [more ▼]

Un cadre théorique de soutien et une boite à outil pédagogique ont été développés dans le cadre du projet BMC-EU (Compétences motrices de base en Europe). Ces documents ont été conçus en tenant compte du concept des compétences motrices de base ainsi que des données collectées dans la phase expérimentale (phase 1) du projet. Ils correspondent à l’étape de production intellectuelle n°3. Le cette boîte à outils s’applique principalement dans le cadre des cours d’éducation physique et offre une approche pédagogique permettant d’initier des adaptations de méthode et de contenu pertinentes dans le contexte d’enseignement de l’éducation physique à l’école primaire. Dans la première partie du document, il est expliqué comment passer du diagnostic des compétences motrices de base des élèves, de l’identification de leurs forces et faiblesses à une intervention concrètes et adaptée. Des supports documentaires sous la forme d'une boîte à outils de soutien pédagogique ont été développés dans le respect du cadre théorique de base. Ces supports ont été développés afin d’être facilement être mis en œuvre dans des situations éducatives concrètes visant à soutenir les élèves présentant des faiblesses au niveau de certaines compétences motrices de base. La boîte à outils pour l’enseignant comprend des directives pour l'interprétation des résultats des tests MOBAK (Motorische Basiskompetenzen; traduction allemande pour les compétences motrices de base), le cadre théorique MOBAK, un glossaire, ainsi que la boîte à outils de soutien pédagogique avec du matériel pour les enseignants d'éducation physique sous la forme de fiches décrivant les tests MOBAK et de fiches d'activités MOBAK basées sur des principes de variation des composantes de coordination et sur une approche axée sur le développement des compétences. [less ▲]

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See detailPagalbinis vadovas mokytojams
Scheuer, Claude UL; Heck, Sandra UL

E-print/Working paper (2020)

Vykdant BMC-EU projektą (Pagrindinės motorinės kompetencijos Europoje), buvo sukurta naudojimosi pagalbos ir pagalbos priemonių rinkinys, pagrįstas pagrindinių motorinių kompetencijų koncepcija ir duomenų ... [more ▼]

Vykdant BMC-EU projektą (Pagrindinės motorinės kompetencijos Europoje), buvo sukurta naudojimosi pagalbos ir pagalbos priemonių rinkinys, pagrįstas pagrindinių motorinių kompetencijų koncepcija ir duomenų rinkimo rezultatais pirmame projekto etape, ir kuris yra dalis trečio intelektinio produkto. Šiuo priemonių rinkiniu siekiama paskatinti jį įgyvendinti, ypatingai per reguliarias fizinio ugdymo pamokas, adaptuojant prie fizinio ugdymo mokymo turinio ir metodų. Pirmame etape buvo sukurta pagalbos sistema, skirta mokinių pagrindinių motorinių kompetencijų įvertinimui ir siekiant įvertinimo metu nustatyti stipriosioms ir silpnosioms pusėms. Remiantis šia sistema, buvo sukurti pagalbos priemonių rinkiniai, paruošti diegti konkrečiose ugdymo situacijose, kad būtų naudingi mokiniams, kuriems reikia pagalbos vystant pagrindinius motorinius įgūdžius. Pagalbos priemonių rinkinį sudaro MOBAK (pagrindinės motorinės kompetencijos) testų rezultatų aiškinimo gairės, MOBAK paramos sistema, žodynėlis, taip pat pagalbos priemonių rinkinys, apimantis priemones fizinio ugdymo mokytojams, MOBAK užduočių aprašymo kortelės ir MOBAK veiklų kortelės su fizinių veiklų variacijomis, remiantis į kompetenciją orientuotu požiūriu. [less ▲]

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See detailManuale modulare per gli insegnanti
Scheuer, Claude UL; Heck, Sandra UL

E-print/Working paper (2020)

Nell’ambito del progetto BMC-EU (Competenze motorie di base in Europa), è stato sviluppato un manuale modulare e un allegato riguardante le competenze motorie di base e ai risultati della raccolta dei ... [more ▼]

Nell’ambito del progetto BMC-EU (Competenze motorie di base in Europa), è stato sviluppato un manuale modulare e un allegato riguardante le competenze motorie di base e ai risultati della raccolta dei dati nella fase 1 del progetto come parte dell’analisi dei risultati nella fase 3. Lo scopo di questo allegato è quello di fungere da strumento per implementare principalmente le lezioni di educazione fisica curriculari, consentendo gli adattamenti dei contenuti e dei metodi in educazione fisica. In una prima fase, è stato sviluppato il framework per ottenere la diagnosi delle competenze motorie di base degli allievi e conoscere i punti di forza e di debolezza identificati nella valutazione attraverso interventi concreti. A tal proposito, sono stati realizzati dei documenti sotto forma di un kit e di un manuale, pronti per essere utilizzati in situazioni didattiche concrete, per sostenere gli allievi con bisogni educativi speciali nelle competenze motorie di base. Il manuale modulare include le linee guida per l'interpretazione dei risultati delle prove MOBAK (Motorische Basiskompetenzen; termine tedesco per le competenze motorie di base), il manuale modulare del MOBAK, un glossario, nonché l’allegato con i materiali per gli insegnanti di educazione fisica sotto forma di scheda descrittiva del MOBAK e schede delle attività basate sui principi di variazione del compito motorio e sull’approccio didattico orientato alla competenza. [less ▲]

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See detailCoronavirus and the Whistleblower: The (Missing) Role of International Law
Kafteranis, Dimitrios UL

E-print/Working paper (2020)

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See detailPodporný metodický materiál pre učiteľov
Scheuer, Claude UL; Heck, Sandra UL

E-print/Working paper (2020)

V rámci projektu BMC-EU (Základné pohybové kompetencie v Európe) bol v prvej fáze projektu na základe koncepcie základných pohybových kompetencií a výsledkov zberu údajov vypracovaný podporný rámec a ... [more ▼]

V rámci projektu BMC-EU (Základné pohybové kompetencie v Európe) bol v prvej fáze projektu na základe koncepcie základných pohybových kompetencií a výsledkov zberu údajov vypracovaný podporný rámec a modulárny podporný súbor nástrojov ako súčasť intelektuálneho výstupu 3. Cieľom tohto súboru nástrojov je implementovať najmä na úrovni pravidelných hodín telesnej výchovy úpravy týkajúce sa obsahu a metód výučby telesnej výchovy. V prvom kroku sa vyvinul podporný rámec na získanie diagnostiky základných pohybových kompetencií detí a žiakov a silných a slabých stránok identifikovaných pri hodnotení až po konkrétne zásahy. Na základe tohto rámca boli vyvinuté podporné materiály vo forme modulárnej podpornej súpravy nástrojov, pripravené na implementáciu v konkrétnych vzdelávacích situáciách na podporu študentov s ďalšími potrebami v základných pohybových kompetenciách. Modulárna podporná sada nástrojov obsahuje pokyny na interpretáciu výsledkov testov MOBAK (Motorische Basiskompetenzen; nemčina pre základné motorické kompetencie), podporný rámec MOBAK, glosár, ako aj modulárnu podpornú sadu nástrojov s materiálmi pre učiteľov telesnej výchovy vo forme MOBAK, karty opisu úloh a karty aktivít MOBAK založené na princípoch variácie a na prístupe orientovanom na kompetencie. [less ▲]

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See detailModulares Support-Toolkit für Lehrkräfte
Scheuer, Claude UL; Heck, Sandra UL

E-print/Working paper (2020)

Im Rahmen des BMC-EU-Projekts (Motorische Basiskompetenzen in Europa) wurden ein Unterstützungsrahmen und ein modulares Unterstützungs-Toolkit auf der Grundlage des Konzepts der grundlegenden motorischen ... [more ▼]

Im Rahmen des BMC-EU-Projekts (Motorische Basiskompetenzen in Europa) wurden ein Unterstützungsrahmen und ein modulares Unterstützungs-Toolkit auf der Grundlage des Konzepts der grundlegenden motorischen Kompetenzen und der Ergebnisse der Datenerfassung in Phase 1 des Projekts als Teil des intellektuellen Outputs 3entwickelt. Ziel dieses Toolkits ist es, hauptsächlich auf der Ebene des regulären Sportunterrichts umgesetzt zu werden, um Anpassungen hinsichtlich der Inhalte und Methoden des Sportunterrichts einzuleiten. In einem ersten Schritt wurde der Unterstützungsrahmen entwickelt, um von der Diagnose der grundlegenden motorischen Kompetenzen der Schülerinnen und Schüler1 und der in der Bewertung identifizierten Stärken und Schwächen zu konkreten Interventionen zu gelangen. Basierend auf diesem Rahmen wurden unterstützende Handouts in Form eines modularen Support-Toolkits entwickelt, die in konkreten Bildungssituationen implementiert werden können, um Schüler mit zusätzlichen Anforderungen an motorische Basiskompetenzen zu unterstützen. Das modulare Support-Toolkit enthält Richtlinien für die Interpretation der Testergebnisse von MOBAK (Motorische Basiskompetenzen), das MOBAK-Unterstützungsrahmen, ein Glossar sowie das modulare Support-Toolkit mit Materialien für Sportlehrer in Form von MOBAK Aufgabenbeschreibungskarten und MOBAK-Aktivitätskarten basierend auf Variationsprinzipien und einem kompetenzorientierten Ansatz. [less ▲]

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See detailΥποστηρικτική εργαλειοθήκη για εκπαιδευτικούς
Scheuer, Claude UL; Heck, Sandra UL

E-print/Working paper (2020)

Στο πλαίσιο του έργου BMC-EU (Βασικές Κινητικές Δεξιότητες στην Ευρώπη) αναπτύχθηκε το πλαίσιο υποστήριξης και η υποστηρικτική εργαλειοθήκη βάση του μοντέλου των βασικών κινητικών δεξιοτήτων και των ... [more ▼]

Στο πλαίσιο του έργου BMC-EU (Βασικές Κινητικές Δεξιότητες στην Ευρώπη) αναπτύχθηκε το πλαίσιο υποστήριξης και η υποστηρικτική εργαλειοθήκη βάση του μοντέλου των βασικών κινητικών δεξιοτήτων και των αποτελεσμάτων από τη συλλογή δεδομένων κατά τη φάση 1 του έργου, το οποίο αποτελεί μέρος της πνευματικής παραγωγής 3. Ο σκοπός της εργαλειοθήκης αυτής είναι να εφαρμοστεί στα μαθήματα φυσικής αγωγής, ώστε να προσαρμοστούν κατάλληλα τόσο το περιεχόμενο όσο και οι μέθοδοι διδασκαλίας της φυσικής αγωγής. Ως πρώτο βήμα, το υποστηρικτικό πλαίσιο αναπτύχθηκε για τη διάγνωση των βασικών κινητικών δεξιοτήτων των μαθητών, καθώς και για την αξιολόγηση των δυνατοτήτων τους, ώστε στη συνέχεια να δημιουργηθούν συγκεκριμένα παρεμβατικά προγράμματα. Με βάση το πλαίσιο αυτό, αναπτύχθηκαν υποστηρικτικά φυλλάδια με τη μορφή της υποστηρικτικής εργαλειοθήκης, έτοιμα προς εφαρμογή σε συγκεκριμένες εκπαιδευτικές συνθήκες για την υποστήριξη μαθητών με πρόσθετες ανάγκες στις βασικές κινητικές δεξιότητες. Η υποστηρικτική εργαλειοθήκη περιλαμβάνει οδηγίες για την ερμηνεία των αποτελεσμάτων του MOBAK (Motorische Basiskompetenzen; Γερμανικά για τις βασικές κινητικές δεξιότητες), το πλαίσιο υποστήριξης ΜΟΒΑΚ, ένα γλωσσάρι, καθώς και την υποστηρικτική εργαλειοθήκη με εργαλεία για καθηγητές φυσικής αγωγής υπό τη μορφή καρτών περιγραφής διαδικασιών και καρτών δραστηριοτήτων ΜΟΒΑΚ, βασισμένα στις αρχές της παραλλαγής των δραστηριοτήτων και σε μία προσέγγιση προσανατολισμένη στις δεξιότητες. [less ▲]

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See detailOn Reductions of Hintikka Sets for Higher-Order Logic
Steen, Alexander UL; Benzmüller, Christoph UL

E-print/Working paper (2020)

Detailed reference viewed: 70 (2 UL)
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See detailModular Support Toolkit for Teachers
Scheuer, Claude UL; Heck, Sandra UL

E-print/Working paper (2020)

In the frame of the BMC-EU project (Basic motor competencies in Europe), a support framework and a modular support toolkit on the basis of the concept of basic motor competences and the results of the ... [more ▼]

In the frame of the BMC-EU project (Basic motor competencies in Europe), a support framework and a modular support toolkit on the basis of the concept of basic motor competences and the results of the data collection in phase 1 of the project was developed as part of intellectual output 3. The aim of this toolkit is to be implemented mainly at the level of regular physical education lessons to initiate adaptations regarding the content and methods in physical education instruction. In a first step, the support framework was developed for getting from the diagnosis of the students’ basic motor competencies and the strengths and weaknesses identified in the assessment to concrete interventions. Based on this framework, supportive handouts in form of a modular support toolkit were developed, ready to be implemented in concrete educational situations to support students with additional needs in basic motor competencies. The modular support toolkit includes guidelines for the interpretation of MOBAK (Motorische Basiskompetenzen; German for basic motor competencies) test results, the MOBAK support framework, a glossary, as well as the modular support toolkit with materials for physical education teachers in the form of MOBAK task description cards and MOBAK activity cards based on principles of variation and on a competence-oriented approach. [less ▲]

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See detailBitcoin Governance as a Decentralized Financial Market Infrastructure
Nabilou, Hossein UL

E-print/Working paper (2020)

Bitcoin is the oldest and most widely established cryptocurrency network with the highest market capitalization among all cryptocurrencies. Although bitcoin (with lowercase b) is increasingly viewed as a ... [more ▼]

Bitcoin is the oldest and most widely established cryptocurrency network with the highest market capitalization among all cryptocurrencies. Although bitcoin (with lowercase b) is increasingly viewed as a digital asset belonging to a new asset class, the Bitcoin network (with uppercase B) is a decentralized financial market infrastructure (dFMI) that clears and settles transactions in its native asset without relying on the conventional financial market infrastructures (FMIs). To be a reliable asset class as well as a dFMI, however, Bitcoin needs to have robust governance arrangements; whether such arrangements are built into the protocol (i.e., on-chain governance mechanisms) or relegated to the participants in the Bitcoin network (i.e., off-chain governance mechanisms), or are composed of a combination of both mechanisms (i.e., a hybrid form of governance). This paper studies Bitcoin governance with a focus on its alleged shortcomings. In so doing, after defining Bitcoin governance and its objectives, the paper puts forward an idiosyncratic governance model whose main objective is to preserve and maximize the main value proposition of Bitcoin, i.e., its censorship-resistant property, which allows participants to transact in an environment with minimum social trust. Therefore, Bitcoin governance, including the processes through which Bitcoin governance crises have been resolved and the standards against which the Bitcoin Improvement Proposals (BIPs) are examined, should be analyzed in light of the prevailing narrative of Bitcoin as a censorship-resistant store of value and payment infrastructure. Within such a special governance model, this paper seeks to identify the potential shortcomings in Bitcoin governance by reference to the major governance crises that posed serious threats to Bitcoin in the last decade. It concludes that the existing governance arrangements in the Bitcoin network have been largely successful in dealing with Bitcoin’s major crises that would have otherwise become existential threats to the Bitcoin network. [less ▲]

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See detailFastField: An Open-Source Toolbox for Efficient Approximation of Deep Brain Stimulation Electric Fields
Baniasadi, Mehri UL; Proverbio, Daniele UL; Goncalves, Jorge UL et al

E-print/Working paper (2020)

Deep brain stimulation (DBS) is a surgical therapy to alleviate symptoms of certain brain disorders by electrically modulating neural tissues. Computational models predicting electric fields and volumes ... [more ▼]

Deep brain stimulation (DBS) is a surgical therapy to alleviate symptoms of certain brain disorders by electrically modulating neural tissues. Computational models predicting electric fields and volumes of tissue activated are key for efficient parameter tuning and network analysis. Currently, we lack efficient and flexible software implementations supporting complex electrode geometries and stimulation settings. Available tools are either too slow (e.g. finite element method–FEM), or too simple, with limited applicability to basic use-cases. This paper introduces FastField, an efficient open-source toolbox for DBS electric field and VTA approximations. It computes scalable e-field approximations based on the principle of superposition, and VTA activation models from pulse width and axon diameter. In benchmarks and case studies, FastField is solved in about 0.2s, ~ 1000 times faster than using FEM. Moreover, it is almost as accurate as using FEM: average Dice overlap of 92%, which is around typical noise levels found in clinical data. Hence, FastField has the potential to foster efficient optimization studies and to support clinical applications [less ▲]

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See detailRadial processes for sub-Riemannian Brownian motions and applications
Baudoin, Fabrice; Grong, Erlend; Kuwada, Kazumasa et al

E-print/Working paper (2020)

We study the radial part of sub-Riemannian Brownian motion in the context of totally geodesic foliations. Itô's formula is proved for the radial processes associated to Riemannian distances approximating ... [more ▼]

We study the radial part of sub-Riemannian Brownian motion in the context of totally geodesic foliations. Itô's formula is proved for the radial processes associated to Riemannian distances approximating the Riemannian one. We deduce very general stochastic completeness criteria for the sub-Riemannian Brownian motion. In the context of Sasakian foliations and H-type groups, one can push the analysis further, and taking advantage of the recently proved sub-Laplacian comparison theorems one can compare the radial processes for the sub-Riemannian distance to one-dimensional model diffusions. As a geometric application, we prove Cheng's type estimates for the Dirichlet eigenvalues of the sub-Riemannian metric balls, a result which seems to be new even in the Heisenberg group. [less ▲]

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See detailMeasuring Pants
Doan, Nhat Minh UL; Parlier, Hugo UL; Tan, Ser Peow

E-print/Working paper (2020)

We investigate the terms arising in an identity for hyperbolic surfaces proved by Luo and Tan, namely showing that they vary monotonically in terms of lengths and that they verify certain convexity ... [more ▼]

We investigate the terms arising in an identity for hyperbolic surfaces proved by Luo and Tan, namely showing that they vary monotonically in terms of lengths and that they verify certain convexity properties. Using these properties, we deduce two results. As a first application, we show how to deduce a theorem of Thurston which states, in particular for closed hyperbolic surfaces, that if a simple length spectrum "dominates" another, then in fact the two surfaces are isometric. As a second application, we show how to find upper bounds on the number of pairs of pants of bounded length that only depend on the boundary length and the topology of the surface. [less ▲]

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See detailChancen der Jugendarbeit und non-formaler Bildung an Schulen
Biewers, Sandra UL

E-print/Working paper (2020)

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See detailDepressionen am Arbeitsplatz in Luxemburg: ein Handlungsfeld
Sischka, Philipp UL; Steffgen, Georges UL

E-print/Working paper (2020)

Im Rahmen dieser Newsletter wird das aktuelle Depressionsrisiko am Arbeitsplatz in Luxemburg vorgestellt. Im Vergleich zu anderen europäischen Ländern weist Luxemburg einen relativ hohen Anteil an ... [more ▼]

Im Rahmen dieser Newsletter wird das aktuelle Depressionsrisiko am Arbeitsplatz in Luxemburg vorgestellt. Im Vergleich zu anderen europäischen Ländern weist Luxemburg einen relativ hohen Anteil an Arbeitnehmern mit Depressionsrisiko. Weibliche Arbeitnehmer sind im Vergleich zu männlichen geringfügig häufiger von einem Depressionsrisiko betroffen. Differenziert nach Beruf sind vor allem Hilfsarbeitskräfte, Manager sowie Arbeitnehmer in Dienstleistungsberufen besonders von einem Depressionsrisiko betroffen. Arbeitnehmer mit Depressionsrisiko berichten über nachteilige Arbeitsbedingungen und weisen auch eine geringere Arbeitsplatzzufriedenheit sowie weitere gesundheitliche Probleme auf. [less ▲]

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See detailExponential contraction in Wasserstein distance on static and evolving manifolds
Cheng, Li Juan UL; Thalmaier, Anton UL; Zhang, Shao-Qin

E-print/Working paper (2020)

In this article, exponential contraction in Wasserstein distance for heat semigroups of diffusion processes on Riemannian manifolds is established under curvature conditions where Ricci curvature is not ... [more ▼]

In this article, exponential contraction in Wasserstein distance for heat semigroups of diffusion processes on Riemannian manifolds is established under curvature conditions where Ricci curvature is not necessarily required to be non-negative. Compared to the results of Wang (2016), we focus on explicit estimates for the exponential contraction rate. Moreover, we show that our results extend to manifolds evolving under a geometric flow. As application, for the time-inhomogeneous semigroups, we obtain a gradient estimate with an exponential contraction rate under weak curvature conditions, as well as uniqueness of the corresponding evolution system of measures. [less ▲]

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See detailA newform theory for Katz modular forms
Berhanu, Daniel UL

E-print/Working paper (2020)

In this paper, a strong multiplicity one theorem for Katz modular forms is studied. We show that a cuspidal Katz eigenform which admits an irreducible Galois representation is in the level and weight old ... [more ▼]

In this paper, a strong multiplicity one theorem for Katz modular forms is studied. We show that a cuspidal Katz eigenform which admits an irreducible Galois representation is in the level and weight old space of a uniquely associated Katz newform. We also set up multiplicity one results for Katz eigenforms which have reducible Galois representation. [less ▲]

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See detailNormal approximation for functions of hidden Markov models
Kerchev, George UL

E-print/Working paper (2020)

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Peer Reviewed
See detailPoverty in Russia: the Role of the Marital Status and Gender
Zanaj, Skerdilajda UL

E-print/Working paper (2020)

Detailed reference viewed: 16 (0 UL)
See detailCausal dynamical modelling predicts novel regulatory genes of FOXP3 in human regulatory T cells
Sawlekar, Rucha UL; Magni, Stefano UL; Chapelle, Christophe et al

E-print/Working paper (2020)

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See detailIn-work poverty in times of pandemic
Ratti, Luca UL

E-print/Working paper (2020)

The coronavirus crisis is exacerbating in-work poverty in the EU—and a powerful raft of labour-market and welfare measures is needed for an adequate response.

Detailed reference viewed: 12 (0 UL)
See detailFrom deformation theory of wheeled props to classification of Kontsevich formality maps
Andersson, Assar UL; Merkulov, Sergei UL

E-print/Working paper (2019)

We study homotopy theory of the wheeled prop controlling Poisson structures on arbitrary formal graded finite-dimensional manifolds and prove, in particular, that Grothendieck-Teichmueller group acts on ... [more ▼]

We study homotopy theory of the wheeled prop controlling Poisson structures on arbitrary formal graded finite-dimensional manifolds and prove, in particular, that Grothendieck-Teichmueller group acts on that wheeled prop faithfully and homotopy non-trivially. Next we apply this homotopy theory to the study of the deformation complex of an arbitrary Maxim Kontsevich formality map and compute the full cohomology group of that deformation complex in terms of the cohomology of a certain graph complex introduced earlier by Maxim Kontsevich in [K1] and studied by Thomas Willwacher in [W1]. [less ▲]

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See detailA Directive to protect whistle-blowers
Kafteranis, Dimitrios UL

E-print/Working paper (2019)

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See detailParliamentary Administrations in EU Politics: The Sources and Impact of Diversity
Högenauer, Anna-Lena UL

E-print/Working paper (2019)

National parliaments tend to delegate a range of tasks related to EU affairs scrutiny to their administrations. However, there is considerable variation in the extent to which national parliaments invest ... [more ▼]

National parliaments tend to delegate a range of tasks related to EU affairs scrutiny to their administrations. However, there is considerable variation in the extent to which national parliaments invest in EU affairs staff. This raises two questions: what is the source of this diversity, and what is its impact on the EU affairs scrutiny of national parliaments? This paper argues that greater investments in EU affairs staff are associated with public Euroscepticism, large parliaments and parliaments with strong scrutiny powers. A large EU staff is, in turn, associated with parliaments that are relatively active in EU affairs scrutiny. This is particularly true for the 15 EU member states that joined before 2004. [less ▲]

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See detailL'espace sportif européen: circulations, organisations et identité européenne
Moreau, Sebastien UL; Sbetti, Nicola; Dufraisse, Sylvain et al

E-print/Working paper (2019)

Dès la fin du xixe siècle, l’espace européen est le cadre d’un développement précoce des échanges sportifs et tient un rôle pionnier dans l’organisation internationale des sports. L’homogénéisation des ... [more ▼]

Dès la fin du xixe siècle, l’espace européen est le cadre d’un développement précoce des échanges sportifs et tient un rôle pionnier dans l’organisation internationale des sports. L’homogénéisation des pratiques et la mise en place de compétitions continentales, processus commencé dans l’entre-deux-guerres et qui se renforce après la Deuxième Guerre mondiale, a comme effet la constitution d’un espace sportif européen. Touchant autant les élites que les masses et le produit d’une intense médiatisation, les sports ont un impact qui dépasse largement les stades et permettent aux Européens de se rencontrer et in fine de mieux se connaître. [less ▲]

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See detailTransport properties of Majorana bound states networks in the Coulomb blockade regime
Ekström, Carl Johan Ingvar UL; Recher, Patrik; Schmidt, Thomas UL

E-print/Working paper (2019)

Topologically protected qubits based on nanostructures hosting Majorana bound states (MBSs) hold great promise for fault-tolerant quantum computing. We study the transport properties of nanowire networks ... [more ▼]

Topologically protected qubits based on nanostructures hosting Majorana bound states (MBSs) hold great promise for fault-tolerant quantum computing. We study the transport properties of nanowire networks hosting MBSs with a focus on the effects of the charging energy and the overlap between neighboring MBSs in short mesoscopic samples. In particular, we investigate structures hosting four MBSs such as T-junctions and Majorana boxes. Using a master equation in the Markovian approximation, we discuss the leading transport processes mediated by the MBSs. Single-electron tunneling and processes involving creation and annihilation of Cooper pairs dominate in the sequential tunneling limit. In the cotunneling regime the charge in the MBSs network is fixed and transport is governed by transitions via virtual intermediate states. Our results show that four-terminal measurements in the T-junction and Majorana box geometries can be useful tools for the characterization of the properties of MBSs with finite overlaps and charging energy. [less ▲]

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See detailThe 2019 European Parliament Elections in Luxembourg in the Context of Past Elections
Högenauer, Anna-Lena UL

E-print/Working paper (2019)

The aim of this article is to analyse the 2019 European election in Luxembourg and to contextualize it by comparing it with past elections. The article presents the party landscape, the electoral campaign ... [more ▼]

The aim of this article is to analyse the 2019 European election in Luxembourg and to contextualize it by comparing it with past elections. The article presents the party landscape, the electoral campaign, the electoral system and the results of the 2019 European election. The results are then analysed in the context of past national and European elections in order to establish whether European elections are second-order elections in Luxembourg, how electoral volatility evolved over time, whether there is a rise in Eurosceptic parties and how the representation of women has evolved since 1979. [less ▲]

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See detailPhase transition for the volume of high-dimensional random polytopes
Bonnet, Gilles; Kabluchko, Zakhar; Turchi, Nicola UL

E-print/Working paper (2019)

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See detailThe conformal group of a compact simply connected Lorentzian manifold
Melnick, Karin; Pecastaing, Vincent UL

E-print/Working paper (2019)

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See detailConstant Gaussian curvature foliations and Schläfli formulas of hyperbolic 3-manifolds
Mazzoli, Filippo UL

E-print/Working paper (2019)

We study the geometry of the foliation by constant Gaussian curvature surfaces (S_k)_k of a hyperbolic end, and how it relates to the structures of its boundary at infinity and of its pleated boundary ... [more ▼]

We study the geometry of the foliation by constant Gaussian curvature surfaces (S_k)_k of a hyperbolic end, and how it relates to the structures of its boundary at infinity and of its pleated boundary. First, we show that the Thurston and the Schwarzian parametrizations are the limits of two families of parametrizations of the space of hyperbolic ends, defined by Labourie in 1992 in terms of the geometry of the leaves S_k. We give a new description of the renormalized volume using the constant curvature foliation. We prove a generalization of McMullen's Kleinian reciprocity theorem, which replaces the role of the Schwarzian parametrization with Labourie's parametrizations. Finally, we describe the constant curvature foliation of a hyperbolic end as the integral curve of a time-dependent Hamiltonian vector field on the cotangent space to Teichmüller space, in analogy to the Moncrief flow for constant mean curvature foliations in Lorenzian space-times. [less ▲]

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See detailDeconstructing Blockchains: A Comprehensive Survey on Consensus, Membership and Structure
Natoli, Christopher; Yu, Jiangshan; Gramoli, Vincent et al

E-print/Working paper (2019)

It is no exaggeration to say that since the introduction of Bitcoin, blockchains have become a disruptive technology that has shaken the world. However, the rising popularity of the paradigm has led to a ... [more ▼]

It is no exaggeration to say that since the introduction of Bitcoin, blockchains have become a disruptive technology that has shaken the world. However, the rising popularity of the paradigm has led to a flurry of proposals addressing variations and/or trying to solve problems stemming from the initial specification. This added considerable complexity to the current blockchain ecosystems, amplified by the absence of detail in many accompanying blockchain whitepapers. Through this paper, we set out to explain blockchains in a simple way, taming that complexity through the deconstruction of the blockchain into three simple, critical components common to all known systems: membership selection, consensus mechanism and structure. We propose an evaluation framework with insight into system models, desired properties and analysis criteria, using the decoupled components as criteria. We use this framework to provide clear and intuitive overviews of the design principles behind the analyzed systems and the properties achieved. We hope our effort will help clarifying the current state of blockchain proposals and provide directions to the analysis of future proposals. [less ▲]

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See detailProjective and conformal closed manifolds with a higher-rank lattice action
Pecastaing, Vincent UL

E-print/Working paper (2019)

We prove global results about actions of cocompact lattices in higher-rank simple Lie groups on closed manifolds endowed with either a projective class of connections or a conformal class of pseudo ... [more ▼]

We prove global results about actions of cocompact lattices in higher-rank simple Lie groups on closed manifolds endowed with either a projective class of connections or a conformal class of pseudo-Riemannian metrics of signature (p,q), with min(p,q)>1. In the continuity of a recent article, provided that such a structure is locally equivalent to its model X, the main question treated here is the completeness of the associated (G,X)-structure. The similarities between the model spaces of non-Lorentzian conformal geometry and projective geometry make that lots of arguments are valid for both cases, and we expose the proofs in parallel. The conclusion is that in both cases, when the real-rank is maximal, the manifold is globally equivalent to either the model space X or its double cover. [less ▲]

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See detailReducibility of n-ary semigroups: from quasitriviality towards idempotency
Couceiro, Miguel; Devillet, Jimmy UL; Marichal, Jean-Luc UL et al

E-print/Working paper (2019)

Let $X$ be a nonempty set. Denote by $\mathcal{F}^n_k$ the class of associative operations $F\colon X^n\to X$ satisfying the condition $F(x_1,\ldots,x_n)\in\{x_1,\ldots,x_n\}$ whenever at least $k$ of the ... [more ▼]

Let $X$ be a nonempty set. Denote by $\mathcal{F}^n_k$ the class of associative operations $F\colon X^n\to X$ satisfying the condition $F(x_1,\ldots,x_n)\in\{x_1,\ldots,x_n\}$ whenever at least $k$ of the elements $x_1,\ldots,x_n$ are equal to each other. The elements of $\mathcal{F}^n_1$ are said to be quasitrivial and those of $\mathcal{F}^n_n$ are said to be idempotent. We show that $\mathcal{F}^n_1=\cdots =\mathcal{F}^n_{n-2}\varsubsetneq\mathcal{F}^n_{n-1}\varsubsetneq\mathcal{F}^n_n$. The class $\mathcal{F}^n_1$ was recently characterized by Couceiro and Devillet \cite{CouDev}, who showed that its elements are reducible to binary associative operations. However, some elements of $\mathcal{F}^n_n$ are not reducible. In this paper, we characterize the class $\mathcal{F}^n_{n-1}\setminus\mathcal{F}^n_1$ and show that its elements are reducible. In particular, we show that each of these elements is an extension of an $n$-ary Abelian group operation whose exponent divides $n-1$. [less ▲]

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See detailLocal Social Interaction and Urban Equilibria
Picard, Pierre M UL; Augeraud-Veron, Emmanuelle; Maruhenda, Francisco

E-print/Working paper (2019)

In this paper we investigate the effect of local interaction in a simple urban economics model. Agents interact with others if and only if their interaction benefit outweights their travel cost and ... [more ▼]

In this paper we investigate the effect of local interaction in a simple urban economics model. Agents interact with others if and only if their interaction benefit outweights their travel cost and therefore meet others only within finite geographic windows. We show that two or more cites may co-exist at the equilibrium provided that they are sufficiently distant. For any interaction surplus function, there exists a unique spatial equilibrium on not too large city supports. The population density within a city is determined by a second order advance-delay differential equation, whose solutions are fully characterized for linear interaction surplus functions. Numerical analyses show that more localized interactions yield flatter population density and land rents over larger extents of the city support. They do not give support to the idea that multiple subcenters can be caused by small and finite geographic windows of interaction. [less ▲]

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See detailBorders and the mobility of migrants in Luxembourg
Paraschivescu, Claudia UL; Nienaber, Birte UL; Oesch, Lucas UL

E-print/Working paper (2019)

This country report sought to explore the border as a site of control and the ways in which it interferes with migrants’ (asylum seekers, refugees and rejected asylum seekers) trajectories before, upon ... [more ▼]

This country report sought to explore the border as a site of control and the ways in which it interferes with migrants’ (asylum seekers, refugees and rejected asylum seekers) trajectories before, upon and after arrival in Luxembourg. To this end, it explored, through qualitative interviews with a total of 29 state and civil society actors and migrants, as well as ethnographic observation at Findel airport, Luxembourg’s only external border, the multiple conceptualisations and experiences of borders. It has identified that the suppression of internal controls within the Schengen area has been accompanied by a surge of controls within the member states, either at the stage of lodging an asylum claim, or at the street level, where migrants can be stopped and searched by police officers. Furthermore, the data showed that the migrants interviewed not only did they experience bordering practices during their interactions with public actors, but they were also subject to bordering during their interactions with private actors from the housing and employment market. The principal finding of this research with regards to the interplay between borders and the mobility of migrants is that cross-border mobility is commonplace, the migrants’ mobility practices reflecting the movements of the local population. As such, borders do not represent efficient mechanisms of control which can prevent migrants’ mobility trajectories. [less ▲]

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See detailBorders and the mobility of migrants in France
Paraschivescu, Claudia UL; Nienaber, Birte UL; Oesch, Lucas UL

E-print/Working paper (2019)

This country report investigates the ways in which the border as a site of control interferes with asylum seekers’ and refugees’ mobility trajectories before, upon and after arrival in France. The ... [more ▼]

This country report investigates the ways in which the border as a site of control interferes with asylum seekers’ and refugees’ mobility trajectories before, upon and after arrival in France. The interplay between borders and mobility plays a key role in the Common European Asylum System, the Schengen area and the Dublin regulation, which all have been affected by the 2015 so-called migration crisis. Based on in-depth qualitative interviews with thirteen migrants and ten institutional actors in the city of Metz, the overarching finding indicates that migrants’ movements evolve from geographical trajectories in order to reach a country of destination, to administrative trajectories, in order to become regularised in the host country. Furthermore, while physical borders have interfered with some informants’ migratory journeys, they have done so only by changing their trajectories, and, at times, the initial country of destination. Thus, they did not deter the migrants from reaching a safe country of destination. Once in Metz, the migrants become subject to administrative borders performed by state agents, such as the Préfecture and the French Agency for Immigration and Integration (OFII), as well as by private actors from the employment market. [less ▲]

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See detailBorders and the mobility of migrants in the EU and Turkey
Paraschivescu, Claudia UL; Nienaber, Birte UL; Oesch, Lucas UL

E-print/Working paper (2019)

This comparative report investigates the ways in which the mobility of applicants for international protection, beneficiaries of international protection and irregular migrants intersect with the borders ... [more ▼]

This comparative report investigates the ways in which the mobility of applicants for international protection, beneficiaries of international protection and irregular migrants intersect with the borders encountered during their trajectories before, during and after their arrival in six EU countries (Greece, Hungary, Germany, Luxembourg, France and Spain) and Turkey. After defining the concept of borders, this study contextualises the securitisation of EU external and internal borders, and it provides some background information on the CEAS and the Dublin Regulation, which are central to this research. Moreover, it engages with the legislative framework in place in the field of asylum in the seven countries on which this report draws. Based on qualitative interviews with a total of 96 asylum seekers, refugees and irregular migrants, as well as 94 state and non-state actors and ethnographic observation, the empirical part of the study explored the following aspects: experiences and conceptualisations of borders; mobility patterns and trajectories; the interplay between the Schengen zone and the Dublin system; the shortcomings of CEAS; as well as policies and experiences in the fields of housing and employment. The main finding of this comparative report is that while territorial borders cannot always impede human mobility, they are recreated within countries as administrative borders, which can encourage secondary movements. [less ▲]

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See detailBelgien und Deutschland: eine kleine Beziehungsgeschichte
Brüll, Christoph UL

E-print/Working paper (2019)

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See detailBrownian Loops, Layering Fields and Imaginary Gaussian Multiplicative Chaos
Camia, Federico; Gandolfi, Alberto; Peccati, Giovanni UL et al

E-print/Working paper (2019)

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See detailBad representations and homotopy groups of Character Varieties
Guerin, Clément UL; Lawton, Sean; Ramras, Daniel

E-print/Working paper (2019)

Let G be a connected, reductive, complex affine algebraic group, and let Xr denote the moduli space of G-valued representations of a rank r free group. We first characterize the singularities in Xr ... [more ▼]

Let G be a connected, reductive, complex affine algebraic group, and let Xr denote the moduli space of G-valued representations of a rank r free group. We first characterize the singularities in Xr resolving conjectures of Florentino-Lawton. In particular, we compute the codimension of the orbifold singular locus using facts about Borel-de Siebenthal groups. We then use this codimension to calculate some higher homotopy groups of the smooth locus of Xr, proving conjectures of Florentino-Lawton-Ramras. Lastly, using the earlier analysis of Borel-de Siebenthal groups, we prove a conjecture of Sikora about CI Lie groups. [less ▲]

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See detailQuasicircles and width of Jordan curves in CP1
bonsante, francesco; danciger, jeffrey; maloni, sara et al

E-print/Working paper (2019)

We study a notion of "width" for Jordan curves in CP1, paying special attention to the class of quasicircles. The width of a Jordan curve is defined in terms of the geometry of its convex hull in ... [more ▼]

We study a notion of "width" for Jordan curves in CP1, paying special attention to the class of quasicircles. The width of a Jordan curve is defined in terms of the geometry of its convex hull in hyperbolic three-space. A similar invariant in the setting of anti de Sitter geometry was used by Bonsante-Schlenker to characterize quasicircles amongst a larger class of Jordan curves in the boundary of anti de Sitter space. By contrast to the AdS setting, we show that there are Jordan curves of bounded width which fail to be quasicircles. However, we show that Jordan curves with small width are quasicircles. [less ▲]

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See detailDual pairs in the Pin-group and duality for the corresponding spinorial representation
Guerin, Clément UL; Liu, Gang; Merino, Allan

E-print/Working paper (2019)

In this paper, we give a complete picture of Howe correspondence for the setting (O(E,b),Pin(E,b),Π), where O(E,b) is an orthogonal group (real or complex), Pin(E,b) is the two-fold Pin-covering of O(E,b ... [more ▼]

In this paper, we give a complete picture of Howe correspondence for the setting (O(E,b),Pin(E,b),Π), where O(E,b) is an orthogonal group (real or complex), Pin(E,b) is the two-fold Pin-covering of O(E,b), and Π is the spinorial representation of Pin(E,b). More precisely, for a dual pair (G,G′) in O(E,b), we determine explicitly the nature of its preimages (G̃,G′~) in Pin(E,b), and prove that apart from some exceptions, (G̃,G′~) is always a dual pair in Pin(E,b); then we establish the Howe correspondence for Π with respect to (G̃,G′~). [less ▲]

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See detailRefining transparency and responsible investment?: The case of EIB and sustainable finance
Alexandraki, Chrysa UL

E-print/Working paper (2019)

On 8 January 2019, an action was brought before the Court of Justice of the European Union (hereafter CJEU) by an environmental law charity, ClientEarth (hereafter applicant) against a multilateral ... [more ▼]

On 8 January 2019, an action was brought before the Court of Justice of the European Union (hereafter CJEU) by an environmental law charity, ClientEarth (hereafter applicant) against a multilateral development bank (hereafter MDB) and European institution, the European Investment Bank (hereafter EIB). The case concerns the financing by the bank of a biomass energy generating project in Northern Spain – Galicia -, of the cost of 60 million euros, followed by the bank’s refusal to refine its decision to finance the aforementioned investment, regardless the applicant’s request for an internal review of this decision on April 2018. The applicant bases the request for an internal review on alleged ‘errors in the assessment of the financing combined with the provision of minimal information regarding the funding decision’. The main claim brought by the applicant involves the annulment of EIB’s refusal to conduct an internal review and subject its decision to scrutiny, as requested under Article 10 of the Aarhus Regulation (hereafter Regulation), bringing into discussion implementation issues of both International and European law. [less ▲]

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See detailRegulating banks for the public? The dilemmas of prudential regulation
Commain, Sébastien UL

E-print/Working paper (2019)

The regulation of banking activities present policymakers with a conundrum: while essential for a healthy and growing economy, they also present important risks of crises that affect all citizens ... [more ▼]

The regulation of banking activities present policymakers with a conundrum: while essential for a healthy and growing economy, they also present important risks of crises that affect all citizens. Prudential regulation is intended to contain the risks while enabling the socially beneficial functions of banks, but the shadow of financial interests influence hangs over the regulatory process. Assessing the reality and extent of this influence, this paper argues, requires first to acquire asound understanding of the social costs and benefits of banking, and the capacity of regulation to promote social welfare. This paper then offers the reader a review of the main issues covered in the literature and suggests some lessons for the study of financial interest groups. [less ▲]

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See detailInsights into protein structural, physicochemical, and functional consequences of missense variants in 1,330 disease-associated human genes 693259
Iqbal, Sumaiya; Jespersen, Jakob B.; Perez-Palma, Eduardo et al

E-print/Working paper (2019)

Inference of the structural and functional consequences of amino acid-altering missense variants is challenging and not yet scalable. Clinical and research applications of the colossal number of ... [more ▼]

Inference of the structural and functional consequences of amino acid-altering missense variants is challenging and not yet scalable. Clinical and research applications of the colossal number of identified missense variants is thus limited. Here we describe the aggregation and analysis of large-scale genomic variation and structural biology data for 1,330 disease-associated genes. Comparing the burden of 40 structural, physicochemical, and functional protein features of altered amino acids with 3-dimensional coordinates, we found 18 and 14 features that are associated with pathogenic and population missense variants, respectively. Separate analyses of variants from 24 protein functional classes revealed novel function-dependent vulnerable features. We then devised a quantitative spectrum, identifying variants with higher pathogenic variant-associated features. Finally, we developed a web resource (MISCAST; http://miscast.broadinstitute.org/) for interactive analysis of variants on linear and tertiary protein structures. The biological impact of missense variants available through the webtool will assist researchers in hypothesizing variant pathogenicity and disease trajectories. [less ▲]

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See detailArbeitsplatzmobbing in Luxemburg - wie groß ist das Problem?
Sischka, Philipp UL; Steffgen, Georges UL

E-print/Working paper (2019)

Im Rahmen dieser Newsletter werden die aktuellen Prävalenzraten zu Mobbing am Arbeitsplatz in Luxemburg vorgestellt. Die Befunde der jährlichen Befragung durch den Quality of Work Index zeigen auf, dass ... [more ▼]

Im Rahmen dieser Newsletter werden die aktuellen Prävalenzraten zu Mobbing am Arbeitsplatz in Luxemburg vorgestellt. Die Befunde der jährlichen Befragung durch den Quality of Work Index zeigen auf, dass die Arbeitsplatzmobbingprävalenz zwischen 2014 und 2018 zwischen 12.4% und 18.1% variiert. Sinnlose Aufgaben und permanente Kritik an der eigenen Arbeit sind die häufigsten Mobbing-Verhaltensweisen, denen Arbeitnehmer ausgesetzt sind. Insbesondere Arbeitnehmer in Dienstleistungsberufen sind hierbei von Mobbing betroffen. Insgesamt beurteilen von Mobbing betroffene Arbeitnehmer ihre Arbeitsbedingungen durchschnittlich schlechter (z.B. weniger Autonomie, mehr Zeitdruck) als Arbeitnehmer, die kein Mobbing erleben. Zudem weisen Arbeitnehmer, die von Mobbing betroffen sind, ein geringeres Wohlbefinden auf. [less ▲]

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See detailThe provision of long-term credit and firm growth
Leon, Florian UL

E-print/Working paper (2019)

This paper investigates whether a higher level of long-term credit provision affects the growth of small and young firms. Firm-level data from more than 20,000 firms in 62 countries are combined with a ... [more ▼]

This paper investigates whether a higher level of long-term credit provision affects the growth of small and young firms. Firm-level data from more than 20,000 firms in 62 countries are combined with a new hand-collected database on short-term and long-term credit provided to the private sector. Using a difference-in-difference framework, our results indicate that, contrary to short-term credit, long-term credit does not stimulate growth of small and young firms. This finding is, at least partially, explained by the differential impact of short-term and long-term credit provision on small and young firms’ access to credit. While the provision of short-term credit alleviates credit constraints faced by small and young firms, a larger provision of longterm bank loans has an opposite impact. Our findings are in line with the hypothesis that an increase of long-term credit provision reflects a lender’s choice to provide more financing to existing clients (intensive margin) to the detriment of firms without previous access to finance (extensive margin). [less ▲]

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See detailOptimal TNFS-secure pairings on elliptic curves with composite embedding degree
Fotiadis, Georgios UL; Martindale, Chloe

E-print/Working paper (2019)

Detailed reference viewed: 64 (3 UL)
See detailMitochondrial morphology provides a mechanism for energy buffering at synapses
Garcia, Guadalupe Clara UL; Bartol, Thomas M.; Phan, Sebastien A. et al

E-print/Working paper (2019)

Mitochondria as the main energy suppliers of eukaryotic cells are highly dynamic organelles that fuse, divide and are transported along the cytoskeleton to ensure cellular energy homeostasis. While these ... [more ▼]

Mitochondria as the main energy suppliers of eukaryotic cells are highly dynamic organelles that fuse, divide and are transported along the cytoskeleton to ensure cellular energy homeostasis. While these processes are well established, substantial evidence indicates that the internal structure is also highly variable in dependence on metabolic conditions. However, a quantitative mechanistic understanding of how mitochondrial morphology affects energetic states is still elusive. To address this question, we here present an agent-based dynamic model using three-dimensional morphologies from electron microscopy tomography which considers the molecular dynamics of the main ATP production components. We apply our modeling approach to mitochondria at the synapse which is the largest energy consumer within the brain. Interestingly, comparing the spatiotemporal simulations with a corresponding space-independent approach, we find minor space dependence when the system relaxes toward equilibrium but a qualitative difference in fluctuating environments. These results suggest that internal mitochondrial morphology is not only optimized for ATP production but also provides a mechanism for energy buffering and may represent a mechanism for cellular robustness. [less ▲]

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See detailIdentification of pathogenic variant enriched regions across genes and gene families
Pérez-Palma, Eduardo; May, Patrick UL; Iqbal, Sumaiya et al

E-print/Working paper (2019)

Missense variant interpretation is challenging. Essential regions for protein function are conserved among gene family members, and genetic variants within these regions are potentially more likely to ... [more ▼]

Missense variant interpretation is challenging. Essential regions for protein function are conserved among gene family members, and genetic variants within these regions are potentially more likely to confer risk to disease. Here, we generated 2,871 gene family protein sequence alignments involving 9,990 genes and performed missense variant burden analyses to identify novel essential protein regions. We mapped 2,219,811 variants from the general population into these alignments and compared their distribution with 65,034 missense variants from patients. With this gene family approach, we identified 398 regions enriched for patient variants spanning 33,887 amino acids in 1,058 genes. As a comparison, testing the same genes individually we identified less patient variant enriched regions involving only 2,167 amino acids and 180 genes. Next, we selected de novo variants from 6,753 patients with neurodevelopmental disorders and 1,911 unaffected siblings, and observed a 5.56-fold enrichment of patient variants in our identified regions (95% C.I. =2.76-Inf, p-value = 6.66×10−8). Using an independent ClinVar variant set, we found missense variants inside the identified regions are 111-fold more likely to be classified as pathogenic in comparison to benign classification (OR = 111.48, 95% C.I = 68.09-195.58, p-value < 2.2e−16). All patient variant enriched regions identified (PERs) are available online through a user-friendly platform for interactive data mining, visualization and download at http://per.broadinstitute.org. In summary, our gene family burden analysis approach identified novel patient variant enriched regions in protein sequences. This annotation can empower variant interpretation. [less ▲]

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See detailLes Lorrains actifs à l'étranger, analyse au niveau communal
Pigeron-Piroth, Isabelle UL; Helfer, Malte UL

E-print/Working paper (2019)

A growing number of people living in Lorraine cross the border for work. Today, there are more than 100 000 commuters, the majority of them working in Luxembourg. The flow of commuters into Luxembourg is ... [more ▼]

A growing number of people living in Lorraine cross the border for work. Today, there are more than 100 000 commuters, the majority of them working in Luxembourg. The flow of commuters into Luxembourg is on the increase, whereas commuting into Germany continues to shrink. The analysis of com-munes of residence shows a high proportion of cross-border commuters living as the active population in close vicinity to Luxembourg, but many also live in communes further afield; this phenomenon is moving beyond the borders and raises many issues: environmental, social and economic … [less ▲]

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See detailA Symbol of History
Danescu, Elena UL

E-print/Working paper (2019)

As the fifth sovereign of the national dynasty since 1890, Grand Duke Jean was a head of state who perfectly embodied the ideals of service to his country and commitment to European integration.

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See detailMonetary Policy Transmission to Consumer Financial Stress and Durable Consumption
Georgarakos, Dimitris; Tatsiramos, Konstantinos UL

E-print/Working paper (2019)

We examine the effects of monetary policy on household self-assessed financial stress and durable consumption using panel data from eighteen annual waves of the British Household Panel Survey. For ... [more ▼]

We examine the effects of monetary policy on household self-assessed financial stress and durable consumption using panel data from eighteen annual waves of the British Household Panel Survey. For identification, we exploit random variation in household exposure to interest rates generated by the random timing of household interview dates with respect to policy rate changes. After accounting for household and month-year-of- interview fixed effects, we uncover significant heterogeneities in the way monetary policy affects household groups that differ in housing and saving status. In particular, an increase in the interest rate induces financial stress among mortgagors and renters, while it lessens financial stress of savers. We find symmetric effects on durable consumption, mainly driven by mortgagors with high debt burden or limited access to liquidity and younger renters who are prospective home buyers. [less ▲]

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Peer Reviewed
See detailles travailleurs frontaliers au Luxembourg et en Suisse : Emploi, Quotidien et Perceptions
Pigeron-Piroth, Isabelle UL; Wille, Christian UL

E-print/Working paper (2019)

Petits pays ayant d’importants besoins de main-d’œuvre, le Luxembourg et la Suisse attirent tous deux un grand nombre de travailleurs frontaliers. C’est dans une perspective comparative que les 19 auteurs ... [more ▼]

Petits pays ayant d’importants besoins de main-d’œuvre, le Luxembourg et la Suisse attirent tous deux un grand nombre de travailleurs frontaliers. C’est dans une perspective comparative que les 19 auteurs impliqués dans ce Cahier Thématique analysent la situation des travailleurs frontaliers dans les principaux pôles d’emploi transfrontaliers (Luxembourg, Bâle, Genève), mais également au Tessin. En tenant compte des éléments contextuels et méthodologiques, géographes, économistes, sociologues et politologues se focalisent sur les questions d’emploi, le quotidien transfrontalier et les perceptions des frontaliers par la société. Cette approche collective et pluridisciplinaire est résumée par les éditeurs en identifiant des enjeux communs pour le Luxembourg et la Suisse. [less ▲]

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See detailLES IMPACTS ECONOMIQUES ET TERRITORIAUX DU TRAVAIL FRON-TALIER SUR LES TERRITOIRES DE RESIDENCE : L’exemple du bassin de Longwy
Belkacem, Rachid; Pigeron-Piroth, Isabelle UL

E-print/Working paper (2019)

This article questions the impacts of cross-border worker mobility on the economic and social devel-opment of their place of residence. We hypothesize that cross-border mobility produces resources for the ... [more ▼]

This article questions the impacts of cross-border worker mobility on the economic and social devel-opment of their place of residence. We hypothesize that cross-border mobility produces resources for the worker, the enterprise and the territory, but it can also be a source of constraints. After a geo-graphical framework of the study, this article analyses the main positive territorial impacts of cross-border mobility. It shows that they contribute to the territorial dynamism of these border regions by attracting new sociological profiles of workers, by revitalizing rural territories (through housing), by limiting the increase of local unemployment and by encouraging a new form of in-place economy. Fi-nally, the paper also shows how such mobility can impede the own development of these border terri-tories, such as via a deeper local social stratification and a lack of highly qualified manpower. [less ▲]

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See detailLe travail frontalier au Luxembourg : éléments de contexte et de portrait statistique
Pigeron-Piroth, Isabelle UL

E-print/Working paper (2019)

In Luxemburg, 44.4% of employees lives across the border and comes from the three neighboring coun-tries. Cross-border work has historic roots. It is a lasting, growing phenomenon, anchored in local econo ... [more ▼]

In Luxemburg, 44.4% of employees lives across the border and comes from the three neighboring coun-tries. Cross-border work has historic roots. It is a lasting, growing phenomenon, anchored in local econo-mies. This contribution underlines the importance of contextual conditions under which these flows have in-creased. It presents the main characteristics and challenges of cross-border work in Luxembourg, in order to compare with Switzerland. [less ▲]

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See detailLes Lorrains actifs à l'étranger : une analyse cartographique au niveau communal
Helfer, Malte UL; Pigeron-Piroth, Isabelle UL

E-print/Working paper (2019)

A growing number of people living in Lorraine cross the border for work. Today, there are more than 100 000 commuters, the majority of them working in Luxembourg. The flow of commuters into Luxem-bourg is ... [more ▼]

A growing number of people living in Lorraine cross the border for work. Today, there are more than 100 000 commuters, the majority of them working in Luxembourg. The flow of commuters into Luxem-bourg is on the increase, whereas commuting into Germany continues to shrink. The analysis of com-munes of residence shows a high proportion of cross-border commuters living as the active population in close vicinity to Luxembourg, but many also live in communes further afield; this phenomenon is moving beyond the borders and raises many issues: environmental, social and economic … [less ▲]

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See detail5. Forschungsbericht zur Weiterentwicklung des Arbeitsqualitätsindexes in Luxemburg
Sischka, Philipp UL; Steffgen, Georges UL

E-print/Working paper (2019)

Der „Quality of Work Index Luxembourg“ (QoW)-Survey, der von der Universität Luxemburg und der luxemburgischen Chambre des Salariés konzipiert wurde (Steffgen, Kohl, 2013; Sischka, Steffgen, 2015, 2016 ... [more ▼]

Der „Quality of Work Index Luxembourg“ (QoW)-Survey, der von der Universität Luxemburg und der luxemburgischen Chambre des Salariés konzipiert wurde (Steffgen, Kohl, 2013; Sischka, Steffgen, 2015, 2016, 2017, 2019), wurde 2018 zum sechsten Mal durchgeführt. Ziel des Surveys ist es, die erlebte Arbeitssituation und -qualität luxemburgischer Arbeitnehmer zu erfassen. Der vorliegende Bericht dokumentiert die psychometrische Testung der Güte des aktuellen Erhebungsinstruments. In einem ersten Schritt erfolgt eine Beschreibung der Befragungsumstände sowie eine demographische Beschreibung der Stichprobe. Da die Erhebung 2018 als Mixed-Mode-Design – telefonische als auch Online-Befragung – durchgeführt wurde, wird auch analysiert, ob Stichprobenunterschiede zwischen den beiden Erhebungsmodi auftreten. Außerdem wird geklärt, ob es hinsichtlich demographischer Eigenschaften der Befragten, hinsichtlich der QoW-Skalen oder hinsichtlich verschiedener Well-Being-Maße zu systematischen Ausfällen seit der letzten Welle gekommen ist. Dann werden die Items der QoW- und Well-Being-Skalen auf fehlende Werte untersucht und es erfolgt eine Beschreibung der Items mittels verteilungsbeschreibender Maßzahlen und Balkendiagramme. In einem nächsten Schritt werden die Skalen mittels verschiedener Reliabilitätsstatistiken (Cronbach’s Alpha, Korrelationsanalysen der Items) sowie Koeffizienten zur Beschreibung der Skalenverteilung überprüft. Außerdem werden die Zusammenhänge der Skalen mittels Korrelationsanalysen überprüft. Im Anschluss daran wird die unterstellte Faktorenstruktur mittels konfirmatorischer Faktoren-analysen getestet. Die QoW-Skalen werden außerdem auf verschiedene Well-Being-Skalen regressiert, um deren Relevanz für den QoW-Index zu prüfen. Ebenso werden einige Längsschnitt-Regressionsanalysen durchgeführt, um zu überprüfen ob einige Arbeitsbedingungen längerfristige Effekte auf das Well-Being der Arbeitnehmer aufweisen. Die QoW-Befragung 2018 hat außerdem das Schwerpunktthema „Work-Life-Balance“ behandelt. Die Güte der Skalen zu diesem Thema wird ebenfalls geprüft. Im Anschluss werden dann Korrelationen mit den QoW- und Well-Being-Skalen berechnet. Abschließend wird das gesamte Erhebungsinstrument zusammenfassend diskutiert und Emp-fehlungen bezüglich zukünftiger Befragungen gegeben. [less ▲]

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See detailDéchiffrer le phénomène des travailleurs transfrontaliers en Suisse
Duchêne-Lacroix, Cédric; Wille, Christian UL; Pigeron-Piroth, Isabelle UL

E-print/Working paper (2019)

Cross-border workers form a little-known but numerous population in Switzerland. Beyond clichés, this contribution brings together the main characteristics of this population based on official statistics ... [more ▼]

Cross-border workers form a little-known but numerous population in Switzerland. Beyond clichés, this contribution brings together the main characteristics of this population based on official statistics and the latest research. The introduction of the Freedom of Movement Agreement did not change the growth trend of the population that remains to live and work in proximity of the border, mostly in France and near-Switzerland agglomerations. Conversely, the occupational areas and levels have diversified. Generally, cross-border workers have no negative influence on the labour market, except on salary level in some economic sectors in Ticino. The initiation of the “priority to Swiss residents” will not change the situation, which relates above all to the economic evolution. [less ▲]

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See detailBORDERS IN THE LIVES OF ASYLUM SEEKERS & REFUGEES IN LUXEMBOURG & METZ
Paraschivescu, Claudia UL

E-print/Working paper (2019)

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See detailWeshalb wechseln Arbeitnehmer ihren Arbeitgeber?
Sischka, Philipp UL; Steffgen, Georges UL

E-print/Working paper (2019)

4,4% der Befragten des Quality of Work Survey hat zwischen den Erhebungen 2017 und 2018 den Arbeitgeber gewechselt. Vor allem die jüngsten Arbeitnehmer (16 bis 24 Jahre) sowie Arbeitnehmer mit einer ... [more ▼]

4,4% der Befragten des Quality of Work Survey hat zwischen den Erhebungen 2017 und 2018 den Arbeitgeber gewechselt. Vor allem die jüngsten Arbeitnehmer (16 bis 24 Jahre) sowie Arbeitnehmer mit einer befristeten Arbeitsstelle wechselten eher ihren Arbeitgeber. Je geringer Partizipation und Feedback, je höher Mobbing, und je geringer Einkommenszufriedenheit, Ausbildungs- und Beförderungsmöglichkeiten ausfallen, desto höher die Wahrscheinlichkeit eines Arbeitgeberwechsels. Arbeitnehmer, die den Arbeitgeber gewechselt haben, weisen dann im Mittel einen Zuwachs an Wohlbefinden auf. [less ▲]

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See detailBig images of two-dimensional pseudo representations
Conti, Andrea UL; Lang, Jaclyn; Medvedovsky, Anna

E-print/Working paper (2019)

For an odd prime p, we study the image of a continuous 2-dimensional (pseudo)representation rho of a profi nite group with coe cients in a local pro-p domain A. Under mild conditions, Bella che has proved ... [more ▼]

For an odd prime p, we study the image of a continuous 2-dimensional (pseudo)representation rho of a profi nite group with coe cients in a local pro-p domain A. Under mild conditions, Bella che has proved that the image of rho contains a nontrivial congruence subgroup of SL2(B) for a certain subring B of A. We prove that the ring B can be slightly enlarged and then described in terms of the conjugate self-twists of rho, symmetries that naturally constrain its image; hence this new B is optimal. We use this result to recover, and in some cases improve, the known large-image results for Galois representations arising from elliptic and Hilbert modular forms due to Serre, Ribet and Momose, and Nekov a r, and p-adic Hida or Coleman families of elliptic modular forms due to Hida, Lang, and Conti-Iovita-Tilouine. [less ▲]

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See detailHyperideal polyhedra in the 3-dimensional anti-de Sitter space
Chen, Qiyu UL; Schlenker, Jean-Marc UL

E-print/Working paper (2019)

We study hyperideal polyhedra in the 3-dimensional anti-de Sitter space AdS3, which are defined as the intersection of the projective model of AdS3 with a convex polyhedron in RP3 whose vertices are all ... [more ▼]

We study hyperideal polyhedra in the 3-dimensional anti-de Sitter space AdS3, which are defined as the intersection of the projective model of AdS3 with a convex polyhedron in RP3 whose vertices are all outside of AdS3 and whose edges all meet AdS3. We show that hyperideal polyhedra in AdS3 are uniquely determined by their combinatorics and dihedral angles, as well as by the induced metric on their boundary together with an additional combinatorial data, and describe the possible dihedral angles and the possible induced metrics on the boundary. [less ▲]

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See detailRank n swapping algebra for Grassmannian
Sun, Zhe UL

E-print/Working paper (2019)

The rank n swapping algebra is the Poisson algebra defined on the ordered pairs of points on a circle using the linking numbers, where a subspace of (K^n×K^{n∗})^r/GL(n,K) is its geometric mode. In this ... [more ▼]

The rank n swapping algebra is the Poisson algebra defined on the ordered pairs of points on a circle using the linking numbers, where a subspace of (K^n×K^{n∗})^r/GL(n,K) is its geometric mode. In this paper, we find an injective Poisson homomorphism from the Poisson algebra on Grassmannian G(n,r) arising from boundary measurement map to the rank n swapping fraction algebra. [less ▲]

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See detailGrothendieck-Teichmueller group, operads and graph complexes: a survey
Merkulov, Sergei UL

E-print/Working paper (2019)

This paper attempts to provide a more or less self-contained introduction into theory of the Grothendieck-Teichmueller group and Drinfeld associators using the theory of operads and graph complexes.

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See detailA Multi-agent approach for in silico simulations of micro-biological systems
Proverbio, Daniele UL; Gallo, Luca; Passalacqua, Barbara et al

E-print/Working paper (2019)

A Multi-agent approach forin silicosimulations ofmicro-biological systemsProverbio D., Gallo L., Passalacqua B., Pellegrino J., Maggiora M.AbstractUsing a Multi-agent systems paradigm, the present project ... [more ▼]

A Multi-agent approach forin silicosimulations ofmicro-biological systemsProverbio D., Gallo L., Passalacqua B., Pellegrino J., Maggiora M.AbstractUsing a Multi-agent systems paradigm, the present project develops, validates and exploits a computa-tionaltestbedthat simulates micro-biological complex systems, namely the aggregation patterns of thesocial amoebaDyctiostelium discoideum. We propose a new design and implementation for managingdiscrete simulations with autonomous agents on a microscopic scale, thus focusing on their social be-havior and mutual interactions. Then, the dependence on the main physical variables is tested, namelydensity and number of amoebas; in addition, we analyze the robustness of the dynamics against var-ious noise sources. Along with these results, we suggest a methodology for further studies that makeuse of our validated model. [less ▲]

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See detailRepatriation Efforts – Luxembourg State Policy Towards Jews during World War II
Bronec, Jakub UL

E-print/Working paper (2019)

Detailed reference viewed: 38 (7 UL)
See detailSingle-cell transcriptomics reveals multiple neuronal cell types in human midbrain-specific organoids
Smits, Lisa UL; Magni, Stefano UL; Grzyb, Kamil UL et al

E-print/Working paper (2019)

Human stem cell-derived organoids have great potential for modelling physiological and pathological processes. They recapitulate in vitro the organisation and function of a respective organ or part of an ... [more ▼]

Human stem cell-derived organoids have great potential for modelling physiological and pathological processes. They recapitulate in vitro the organisation and function of a respective organ or part of an organ. Human midbrain organoids (hMOs) have been described to contain midbrain-specific dopaminergic neurons that release the neurotransmitter dopamine. However, the human midbrain contains also additional neuronal cell types, which are functionally interacting with each other. Here, we analysed hMOs at high-resolution by means of single-cell RNA-sequencing (scRNA-seq), imaging and electrophysiology to unravel cell heterogeneity. Our findings demonstrate that hMOs show essential neuronal functional properties as spontaneous electrophysiological activity of different neuronal subtypes, including dopaminergic, GABAergic, and glutamatergic neurons. Recapitulating these in vivo features makes hMOs an excellent tool for in vitro disease phenotyping and drug discovery. [less ▲]

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See detailScalable Viewing. Digitale Methoden und die Digital Humanities
Pause, Johannes UL; Walkowski, Niels-Oliver UL

E-print/Working paper (2019)

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See detailEnergy policies for eco-friendly households in Luxembourg—a study based on the LuxHEI model
Poncin, Stéphane Louis Maxim UL

E-print/Working paper (2019)

In the Grand Duchy of Luxembourg, the residential building sector is a major energy consumer and greenhouse gases emitter that is considered key in achieving the country's climate goals. The purpose of ... [more ▼]

In the Grand Duchy of Luxembourg, the residential building sector is a major energy consumer and greenhouse gases emitter that is considered key in achieving the country's climate goals. The purpose of this paper is to assess the effectiveness of the most important policy instruments in achieving savings in the final energy consumption and direct CO2 emissions of Luxembourgish households. Our study is based on the LuxHEI model, which is an enhanced and upgraded version of the well-known French simulation model Res-IRF. This variant has been adjusted to the particular problems of a small country with growing economy and a quickly increasing population. The LuxHEI model goes beyond standard energy-economy models by incorporating global warming as a decision-making factor. The model outcomes reveal that total environmental and economic effectiveness increases if energy policy tools are applied concurrently. In 2060, and compared to the no-policy baseline scenario, the most aspirational policy mix enables energy savings of 42% and an emission mitigation of 60%. From our results we can draw the following policy implications: for a significant improvement of the sector's energy efficiency and sufficiency, (1) the implementation of a remediation duty for existing buildings and (2) the tightening of the performance standards for new constructions, (3) combined with a national carbon tax, are crucial. [less ▲]

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See detail4. Forschungsbericht zur Weiterentwicklung des Arbeitsqualitätsindexes in Luxemburg
Sischka, Philipp UL; Steffgen, Georges UL

E-print/Working paper (2019)

Der Survey zu dem „Quality of Work Index Luxembourg“ (QoW), der von der Universität Luxemburg und der luxemburgischen Chambré des Salariés entwickelt wurde (Steffgen, Kohl, 2013; Sischka, Steffgen, 2015 ... [more ▼]

Der Survey zu dem „Quality of Work Index Luxembourg“ (QoW), der von der Universität Luxemburg und der luxemburgischen Chambré des Salariés entwickelt wurde (Steffgen, Kohl, 2013; Sischka, Steffgen, 2015, 2016, 2017), wurde 2017 bereits zum fünften Mal mittels einer telefonischen Befragung durchgeführt. Ziel des Index ist es, die erlebte Arbeitssituation und -qualität luxemburgischer Arbeitnehmer zu erfassen. Der vorliegende Bericht dokumentiert die psychometrische Testung der Güte des aktuellen Erhebungsinstruments. Dazu erfolgt zunächst eine Beschreibung der für die Skalen genutzten Items, die Überprüfung der internen Konsistenz der jeweiligen Skala mittels verschiedener Reliabilitätsstatistiken (Cronbach’s Alpha, Korrelationsanalysen der Items) sowie Koeffizienten zur Beschreibung der Skalenverteilung. Konfirmatorische Faktorenanalysen dienen dazu, zu testen, ob die Items auf den a priori festgelegten Faktoren laden und ob sich die unterstellte Faktorenstruktur auch in den Daten zeigt. Außerdem werden die Zusammenhänge der Skalen mittels Korrelationsanalysen über-prüft. Die QoW-Skalen werden außerdem auf verschiedene Well-Being-Skalen regressiert, um deren Relevanz für den QoW-Index zu prüfen. Da der QoW Survey teilweise als Panelbefragung durchgeführt wird, wird außerdem geklärt, ob es hinsichtlich demographischer Eigenschaften der Befragten, hinsichtlich der QoW-Skalen oder hinsichtlich verschiedener Well-Being-Maße zu systematischen Ausfällen seit der letzten Welle gekommen ist. Ebenso werden einige Längsschnitt-Regressionsanalysen gerechnet, um zu überprüfen, ob einige Arbeitsbedingungen längerfristige Effekte auf das Well-Being der Arbeitnehmer aufweisen. Die QoW-Befragung 2017 hat außerdem das Schwerpunktthema „Digitalisierung“ behandelt. Die Themenblöcke werden mittels Latenter Profile-Analysen untersucht. Im Anschluss wird überprüft ob sich die extrahierten Profile hinsichtlich der QoW- und der Well-Being-Skalen unterscheiden. Abschließend wird das gesamte Erhebungsinstrument zusammenfassend diskutiert und Empfehlungen bezüglich der weiteren Entwicklung der Skalen gegeben. [less ▲]

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