References of "E-prints/Working papers"
     in
Bookmark and Share    
Full Text
See detailThe mod 2 cohomology rings of congruence subgroups in the Bianchi groups
Berkove, Ethan; Lakeland, Grant; Rahm, Alexander UL

E-print/Working paper (in press)

We provide new tools for the calculation of the torsion in the cohomology of congruence subgroups in the Bianchi groups : An algorithm for finding particularly useful fundamental domains, and an analysis ... [more ▼]

We provide new tools for the calculation of the torsion in the cohomology of congruence subgroups in the Bianchi groups : An algorithm for finding particularly useful fundamental domains, and an analysis of the equivariant spectral sequence combined with torsion subcomplex reduction. [less ▲]

Detailed reference viewed: 321 (23 UL)
Full Text
See detailThe edge-based strain smoothing method for compressible and nearly incompressible non-linear elasticity for solid mechanics
Lee, Chang-Kye; Mihai, L. Angela; Kerfriden, Pierre et al

E-print/Working paper (in press)

Detailed reference viewed: 560 (41 UL)
Full Text
See detailYolanda von Vianden und das Yolanda-Epos
Sieburg, Heinz UL

E-print/Working paper (in press)

Detailed reference viewed: 165 (10 UL)
Full Text
Peer Reviewed
See detailRubik's Snakes on a plane
Grotto, Francesco UL; Perucca, Antonella UL; Van Steenbergen Bergeron, Tatjana

E-print/Working paper (2023)

Detailed reference viewed: 136 (38 UL)
Full Text
Peer Reviewed
See detailKummer theory for multiquadratic or quartic cyclic number fields
Perissinotto, Flavio UL; Perucca, Antonella UL

E-print/Working paper (2023)

Detailed reference viewed: 102 (15 UL)
Full Text
Peer Reviewed
See detailKummer theory for products of one-dimensional tori
Perissinotto, Flavio UL; Perucca, Antonella UL

E-print/Working paper (2023)

Let T be a finite product of one-dimensional tori defined over a number field K. We consider the torsion-Kummer extension K(T[nt], (1/n)G), where n,t are positive integers and G is a finitely generated ... [more ▼]

Let T be a finite product of one-dimensional tori defined over a number field K. We consider the torsion-Kummer extension K(T[nt], (1/n)G), where n,t are positive integers and G is a finitely generated group of K-points on T. We show how to compute the degree of K(T[nt], (1/n)G) over K and how to determine whether T is split over such an extension. If K=Q, then we may compute at once the degree of the above extensions for all n and t. [less ▲]

Detailed reference viewed: 142 (39 UL)
Full Text
See detailThe Zoom City: Working From Home, Urban Productivity and Land Use
Picard, Pierre M UL; Efthymia, Kyriakopoulouy

E-print/Working paper (2022)

Who will benefit and who will lose from a permanent increase in working from home (WFH)? This paper investigates the impact of WFH on cities of different sizes, highlights the dangers of too much WFH, and ... [more ▼]

Who will benefit and who will lose from a permanent increase in working from home (WFH)? This paper investigates the impact of WFH on cities of different sizes, highlights the dangers of too much WFH, and discusses aspects of the disagreement between workers and firms. Our results suggest that WFH raises urban productivity and average wages only in large cities. We also study the optimal fraction of WFH and show that workers-residents have incentives to adopt an inefficiently high WFH scheme. The implementation of remote work in the short run---at fixed rents and wages---implies higher benefits for long-distance commuters and lower benefits or even losses for short-distance ones. It also implies benefits for some firms and losses for others, which potentially explains the low prevalence of WFH before the pandemic. Finally, we show that advances in digital technology, which increase the productivity of remote workers, lead to increased welfare benefits. A calibration exercise for the average and the largest European capital cities sheds more light on the impact of WFH on cities of different sizes. [less ▲]

Detailed reference viewed: 20 (6 UL)
Peer Reviewed
See detail#Climate Killer Internet - Didaktischer Kommentar
Baumann, Isabell Eva UL; Harion, Dominic UL

E-print/Working paper (2022)

Detailed reference viewed: 20 (1 UL)
Peer Reviewed
See detail#Involution - Didaktischer Kommentar
Harion, Dominic UL; Kiefer, Ann UL

E-print/Working paper (2022)

Detailed reference viewed: 14 (1 UL)
Peer Reviewed
See detail#Discover Life on Mars with a Rover - Didaktischer Kommentar
Baumann, Sandra UL; Harion, Dominic UL; Kiefer, Ann UL

E-print/Working paper (2022)

Detailed reference viewed: 18 (1 UL)
Full Text
See detailConvolution, aggregation and attention based deep neural networks for accelerating simulations in mechanics
Deshpande, Saurabh UL; Sosa, Raul Ian UL; Bordas, Stéphane UL et al

E-print/Working paper (2022)

Deep learning surrogate models are being increasingly used in accelerating scientific simulations as a replacement for costly conventional numerical techniques. However, their use remains a significant ... [more ▼]

Deep learning surrogate models are being increasingly used in accelerating scientific simulations as a replacement for costly conventional numerical techniques. However, their use remains a significant challenge when dealing with real-world complex examples. In this work, we demonstrate three types of neural network architectures for efficient learning of highly nonlinear deformations of solid bodies. The first two architectures are based on the recently proposed CNN U-NET and MAgNET (graph U-NET) frameworks which have shown promising performance for learning on mesh-based data. The third architecture is Perceiver IO, a very recent architecture that belongs to the family of attention-based neural networks–a class that has revolutionised diverse engineering fields and is still unexplored in computational mechanics. We study and compare the performance of all three networks on two benchmark examples, and show their capabilities to accurately predict the non-linear mechanical responses of soft bodies. [less ▲]

Detailed reference viewed: 20 (0 UL)
Full Text
See detailForecasting of a complex microbial community using meta-omics
Delogu, Francesco UL; Kunath, Benoît UL; Queirós, P. M. et al

E-print/Working paper (2022)

Microbial communities are complex assemblages whose dynamics are shaped by abiotic and biotic factors. A major challenge concerns correctly forecasting the community behaviour in the future. In this ... [more ▼]

Microbial communities are complex assemblages whose dynamics are shaped by abiotic and biotic factors. A major challenge concerns correctly forecasting the community behaviour in the future. In this context, communities in biological wastewater treatment plants (BWWTPs) represent excellent model systems, because forecasting them is required to ultimately control and operate the plants in a sustainable manner. Here, we forecast the microbial community from the water-air interface of the anaerobic tank of a BWWTP via longitudinal meta-omics (metagenomics, metatranscriptomics and metaproteomics) data covering 14 months at weekly intervals. We extracted all the available time-dependent information, summarised it in 17 temporal signals (explaining 91.1 of the temporal variance) and linked them over time to rebuild the sequence of ecological phenomena behind the community dynamics. We forecasted the signals over the following five years and tested the predictions with 21 extra samples. We were able to correctly forecast five signals accounting for 22.5 of the time-dependent information in the system and generate mechanistic predictions on the ecological events in the community (e.g. a predation cycle involving bacteria, viruses and amoebas). Through the forecasting of the 17 signals and the environmental variables readings we reconstructed the gene abundance and expression for the following 5 years, showing a nearly perfect trend prediction (coefficient of determination >= 0.97) for the first 2 years. The study demonstrates the maturity of microbial ecology to forecast composition and gene expression of open microbial ecosystems using year-spanning interactions between community cycles and environmental parameters. [less ▲]

Detailed reference viewed: 41 (4 UL)
Full Text
See detailSecond Order Bismut formulae and applications to Neumann semigroups on manifolds
Cheng, Li-Juan; Thalmaier, Anton UL; Wang, Feng-Yu

E-print/Working paper (2022)

Detailed reference viewed: 26 (4 UL)
Full Text
See detailHessian estimates for Dirichlet and Neumann eigenfunctions of Laplacian
Cheng, Li-Juan; Thalmaier, Anton UL

E-print/Working paper (2022)

Detailed reference viewed: 53 (5 UL)
Full Text
See detailOptimal coalition splitting with heterogenous strategies
Boucekkine, Raouf; Camcho, Carmen; Ruan, Weihua et al

E-print/Working paper (2022)

We consider a group of players initially members of a coalition managing cooperatively a public bad, in this case, the stock of pollution. Countries are technologically heterogeneous but the pollution ... [more ▼]

We consider a group of players initially members of a coalition managing cooperatively a public bad, in this case, the stock of pollution. Countries are technologically heterogeneous but the pollution damage is uniform. We essentially attempt to characterize the conditions under which a country may eventually split and when it splits within an infinite horizon multi-stage differential game. In contrast to the existing literature, we do not assume that after splitting, the splitting player and the remaining coalition will adopt Markovian strategies. Instead, we assume that the latter will remain committed to the collective control of pollution and play open-loop, while the splitting player plays Markovian. Within a full linear-quadratic model, we characterize the optimal strategies. We later compare with the outcomes of the case where the splitting player and the remaining coalition play both Markovian. We highlight several interesting results in terms of the implications for long- term pollution levels and the duration of coalitions with heterogeneous strategies. [less ▲]

Detailed reference viewed: 33 (4 UL)
See detailThe geometric data on the boundary of convex subsets of hyperbolic manifolds
chen, qiyu; Schlenker, Jean-Marc UL

E-print/Working paper (2022)

Let $N$ be a geodesically convex subset in a convex co-compact hyperbolic manifold $M$ with incompressible boundary. We assume that each boundary component of $N$ is either a boundary component of ... [more ▼]

Let $N$ be a geodesically convex subset in a convex co-compact hyperbolic manifold $M$ with incompressible boundary. We assume that each boundary component of $N$ is either a boundary component of $\partial_\infty M$, or a smooth, locally convex surface in $M$. We show that $N$ is uniquely determined by the boundary data defined by the conformal structure on the boundary components at infinity, and by either the induced metric or the third fundamental form on the boundary components which are locally convex surfaces. We also describe the possible boundary data. This provides an extension of both the hyperbolic Weyl problem and the Ahlfors-Bers Theorem. Using this statement for quasifuchsian manifolds, we obtain existence results for similar questions for convex domains $\Omega\subset \HH^3$ which meets the boundary at infinity $\partial_{\infty}\HH^3$ either along a quasicircle or along a quasidisk. The boundary data then includes either the induced metric or the third fundamental form in $\HH^3$, but also an additional ``gluing'' data between different components of the boundary, either in $\HH^3$ or in $\partial_\infty\HH^3$. [less ▲]

Detailed reference viewed: 21 (0 UL)
See detailSpatio-temporal programming of lyotropic phase transition in nanoporous microfluidic confinements
Ulaganathan, Vamseekrishna UL; Ong, Irvine UL; Sengupta, Anupam UL

E-print/Working paper (2022)

Self-assembly of simple molecules into complex phases can be driven by physical constraints, for instance, due to selective molecular uptake by nanoporous surfaces. Despite the significance of surface ... [more ▼]

Self-assembly of simple molecules into complex phases can be driven by physical constraints, for instance, due to selective molecular uptake by nanoporous surfaces. Despite the significance of surface-mediated assembly in evolution of life, physical routes to molecular enrichment and assembly have remained overlooked. Here, using a lyotropic chromonic liquid crystal as model biological material, confined within nanoporous microfluidic environments, we study molecular assembly driven by nanoporous substrates. We demonstrate that nanoporous polydimethylsiloxane (PDMS) surfaces, due to selective permeation of water molecules, drive transition of disordered isotropic phase to ordered nematic, and higher order columnar phases under isothermal conditions. Synergistically, by tailoring the wettability, the surface-to-volume ratio, and surface topography of the confinements, we program the lyotropic phase transitions with a high degree of spatial and temporal control. Using a combination of timelapse polarized imaging, quantitative image processing, and a simple mathematical model, we analyze the phase transitions, and construct a master diagram capturing the role of surface wettability and channel geometry on programmable lyotropic phase transitions. Intrinsic PDMS nanoporosity and confinement cross-section, together with the imposed wettability regulate the rate of the N-M phase transition; whereas the microfluidic geometry and embedded topography enable phase transition at targeted locations. We harness the emergent long-range order during N-M transition to actuate elasto-advective transport of embedded micro-cargo, demonstrating particle manipulation concepts governed by tunable phase transitions. Our results present a programmable physical route to material assembly, and offer a new paradigm for assembling genetic components, biological cargo, and minimal synthetic cells. [less ▲]

Detailed reference viewed: 33 (3 UL)
Full Text
See detailEU acts without binding legal force producing binding legal effects at the national level: Enforcement of ESA soft law in the Czech Republic
Hubkova, Pavlina UL

E-print/Working paper (2022)

The European Supervisory Authorities (ESAs) are empowered, by their founding regulations, to adopt guidelines and recommendations “with a view to establishing consistent, efficient and effective ... [more ▼]

The European Supervisory Authorities (ESAs) are empowered, by their founding regulations, to adopt guidelines and recommendations “with a view to establishing consistent, efficient and effective supervisory practices within the ESFS, and to ensuring the common, uniform and consistent application of Union law”. These acts can be considered genuine EU soft law since they lack the binding legal force. However, they remain perfectly non-binding only at the EU level and in the relation between the ESAs and the national competent authorities (NCAs). Although the NCAs have a duty “to make every effort to comply” with such soft law, they keep a certain leeway to decide whether they eventually comply or not. Nonetheless, the situation is different in case of financial institutions under their supervision. Formally, the EU regulations attribute to them also only a duty “to make every effort to comply”. However, once the NCA decides to comply and effectively enforces the compliance from financial institutions, the latter have a very limited, or even no leeway to decide about the compliance. Within the complex regulatory system, the NCA metamorphosis from a normtaker into an effective norm-enforcer who is capable to determine what effects the ESA soft law have at the national level. This paper focuses on the life of ESA soft law in the Czech Republic. It examines the role and power of the Czech NCA (the Czech National Bank, CNB) in the light of the legislative framework and other domestic binding legal rules. It takes into consideration the real enforcement strategy and practices of the CNB to show that, in the hands of the CNB, ESA guidelines and recommendations become acts, which produce binding legal effects upon financial institutions. Based on this observation, the paper raises questions about the proper control of ESA soft law and potential remedies. [less ▲]

Detailed reference viewed: 11 (1 UL)
Full Text
See detailOptimal Timing of Carbon Capture and Storage Policies - a Social Planner's View
Chen, Yiwen; Wan, Xi; Zou, Benteng UL

E-print/Working paper (2022)

Carbon capture and storage (CCS) is considered one of the most realistic and plausible options for reducing greenhouse gas (GHG) emissions from large pollution sources. However, CCS deployment is costly ... [more ▼]

Carbon capture and storage (CCS) is considered one of the most realistic and plausible options for reducing greenhouse gas (GHG) emissions from large pollution sources. However, CCS deployment is costly. This paper considers the social cost of CCS projects and GHG damage from a central planer's point of view, providing clear information about when each player should deploy CCS. The findings are twofold: (1) given the heterogeneity of players, it is not socially optimal for all players to start CCS projects at the same time; instead, the player that has a cost advantage should start first; (2) it may be socially desirable for the player with a cost disadvantage never starts CCS. We show the conditions that support both possibilities. The second finding provides a clear policy guideline for the decision-maker: reduce the costs of the high-cost player in order to reduce global GHG emissions, provided that is the aim of the supranational institute. [less ▲]

Detailed reference viewed: 65 (3 UL)
Full Text
See detailValue-Added Scores Show Limited Stability over Time in Primary School
Emslander, Valentin UL; Levy, Jessica; Scherer, Ronny et al

E-print/Working paper (2022)

Value-added (VA) models are used for accountability purposes and quantify the value a teacher or a school adds to their students’ achievement. If VA scores lack stability over time and vary across outcome ... [more ▼]

Value-added (VA) models are used for accountability purposes and quantify the value a teacher or a school adds to their students’ achievement. If VA scores lack stability over time and vary across outcome domains (e.g., mathematics and language learning), their use for high-stakes decision making is in question and could have detrimental real-life implications: teachers could lose their jobs, or a school might receive less funding. However, school-level stability over time and variation across domains have rarely been studied together. In the present study, we examined the stability of VA scores over time for mathematics and language learning, drawing on representative, large-scale, and longitudinal data from two cohorts of standardized achievement tests in Luxembourg (N = 7,016 students in 151 schools). We found that only 34-38% of the schools showed stable VA scores over time with moderate rank correlations of VA scores from 2017 to 2019 of r = .34 for mathematics and r = .37 for language learning. Although they showed insufficient stability over time for high- stakes decision making, school VA scores could be employed to identify teaching or school practices that are genuinely effective—especially in heterogeneous student populations. [less ▲]

Detailed reference viewed: 35 (1 UL)
Full Text
See detailIntegration of external biomass reactions into existing metabolic models
Moscardo Garcia, Maria UL; Pires Pacheco, Maria Irene UL; Sauter, Thomas UL

E-print/Working paper (2022)

Currently, seven biomass objective functions have been defined in human metabolic reconstructions. The integration of published biomass reactions into alternative models can contribute to the prediction ... [more ▼]

Currently, seven biomass objective functions have been defined in human metabolic reconstructions. The integration of published biomass reactions into alternative models can contribute to the prediction power of the model. Thus, in this work, we present a workflow to integrate reactions and biomass functions originating from several genome-scale reconstructions into models other than their home models. Additionally, a benchmark to identify the biomass that confers the highest prediction accuracy in terms of gene essentiality and growth predictions is provided. [less ▲]

Detailed reference viewed: 22 (0 UL)
Full Text
See detailA dynamic programming approach to optimal pollution control under uncertain irreversibility: The Poisson case
Boucekkine, Raouf; Ruan, Weihua; Zou, Benteng UL

E-print/Working paper (2022)

We solve a bimodal optimal control problem with a non-concavity and uncertainty through a Poisson process underlying the transition from a mode to another. We use a dynamic programming approach and are ... [more ▼]

We solve a bimodal optimal control problem with a non-concavity and uncertainty through a Poisson process underlying the transition from a mode to another. We use a dynamic programming approach and are able to uncover the global optimal dynamics (including optimal non-monotonic paths) under a few linear-quadratic assumption, which do not get rid of the non-concavity of the problem. This is in contrast to the related literature on pollution control under irreversibility which usually explores local dynamics along monotonic solution paths to first order Pontryagin conditions. [less ▲]

Detailed reference viewed: 38 (4 UL)
Full Text
See detailAgent-based Model of Initial Token Allocations: Evaluating Wealth Concentration in Fair Launches
Delgado Fernandez, Joaquin UL; Barbereau, Tom Josua UL; Papageorgiou, Orestis UL

E-print/Working paper (2022)

With advancements in distributed ledger technologies and smart contracts, tokenized voting rights gained prominence within Decentralized Finance (DeFi). Voting rights tokens (aka. governance tokens) are ... [more ▼]

With advancements in distributed ledger technologies and smart contracts, tokenized voting rights gained prominence within Decentralized Finance (DeFi). Voting rights tokens (aka. governance tokens) are fungible tokens that grant individual holders the right to vote upon the fate of a project. The motivation behind these tokens is to achieve decentral control. Because the initial allocations of these tokens is often un-democratic, the DeFi project Yearn Finance experimented with a fair launch allocation where no tokens are pre-mined and all participants have an equal opportunity to receive them. Regardless, research on voting rights tokens highlights the formation of oligarchies over time. The hypothesis is that the tokens' tradability is the cause of concentration. To examine this proposition, this paper uses an Agent-based Model to simulate and analyze the concentration of voting rights tokens post fair launch under different trading modalities. It serves to examine three distinct token allocation scenarios considered as fair. The results show that regardless of the allocation, concentration persistently occurs. It confirms the hypothesis that the disease is endogenous: the cause of concentration is the tokens tradablility. The findings inform theoretical understandings and practical implications for on-chain governance mediated by tokens. [less ▲]

Detailed reference viewed: 119 (13 UL)
Full Text
See detailLocal Verlet buffer approach for broad-phase interaction detection in Discrete Element Method
Mainassara Chekaraou, Abdoul Wahid UL; Besseron, Xavier UL; Rousset, Alban UL et al

E-print/Working paper (2022)

The Extended Discrete Element Method (XDEM) is an innovative numerical simulation technique that extends the dynamics of granular materials known as Discrete Element Method (DEM) by additional properties ... [more ▼]

The Extended Discrete Element Method (XDEM) is an innovative numerical simulation technique that extends the dynamics of granular materials known as Discrete Element Method (DEM) by additional properties such as the thermodynamic state, stress/strain for each particle. Such DEM simulations used by industries to set up their experimental processes are complexes and heavy in computation time. At each time step, those simulations generate a list of interacting particles and this phase is one of the most computationally expensive parts of a DEM simulation. The Verlet buffer method, initially introduced in Molecular Dynamic (MD) (and also used in DEM), allows keeping the interaction list for many time steps by extending each particle neighbourhood by a certain extension range, and thus broadening the interaction list. The method relies on the temporal coherency of DEM, which guarantees that no particles move erratically from one time step to the next. In the classical approach, all the particles have their neighbourhood extended by the same value which leads to suboptimal performances in simulations where different flow regimes coexist. Additionally, and unlike in MD, there is no comprehensive study analysing the different parameters that affect the performance of the Verlet buffer method in DEM. In this work, we propose a new method for the dynamic update of the neighbour list that depends on the particles individual displacement and define a particle-specific extension range based on the local flow regime. The interaction list is analysed throughout the simulation based on the particle's displacement allowing a flexible update according to the flow regime conditions. We evaluate the influence of the Verlet extension range on the execution time through different test cases and analyse empirically the extension range value giving the best performance. [less ▲]

Detailed reference viewed: 263 (84 UL)
Full Text
See detailA generalization of Bohr-Mollerup's theorem for higher order convex functions: A tutorial
Marichal, Jean-Luc UL; Zenaïdi, Naïm

E-print/Working paper (2022)

In its additive version, Bohr-Mollerup's remarkable theorem states that the unique (up to an additive constant) convex solution $f(x)$ to the equation $\Delta f(x)=\ln x$ on the open half-line $(0,\infty ... [more ▼]

In its additive version, Bohr-Mollerup's remarkable theorem states that the unique (up to an additive constant) convex solution $f(x)$ to the equation $\Delta f(x)=\ln x$ on the open half-line $(0,\infty)$ is the log-gamma function $f(x)=\ln\Gamma(x)$, where $\Delta$ denotes the classical difference operator and $\Gamma(x)$ denotes the Euler gamma function. In a recently published open access book, the authors provided and illustrated a far-reaching generalization of Bohr-Mollerup's theorem by considering the functional equation $\Delta f(x)=g(x)$, where $g$ can be chosen in a wide and rich class of functions that have convexity or concavity properties of any order. They also showed that the solutions $f(x)$ arising from this generalization satisfy counterparts of many properties of the log-gamma function (or equivalently, the gamma function), including analogues of Bohr-Mollerup's theorem itself, Burnside's formula, Euler's infinite product, Euler's reflection formula, Gauss' limit, Gauss' multiplication formula, Gautschi's inequality, Legendre's duplication formula, Raabe's formula, Stirling's formula, Wallis's product formula, Weierstrass' infinite product, and Wendel's inequality for the gamma function. In this paper, we review the main results of this new and intriguing theory and provide an illustrative application. [less ▲]

Detailed reference viewed: 41 (5 UL)
Full Text
See detailEarly-to-mid idiopathic Parkinson’s disease shows a more cytotoxic but declined CD8-regulatory peripheral immune profile
Capelle, Christophe; Cire, Séverine; Hansen, Maxime UL et al

E-print/Working paper (2022)

Parkinson’s disease (PD) is the second most common neurodegenerative disease. Brain neuroinflammation plays a role in PD pathogenesis. However, the involvement of the peripheral immune system has not been ... [more ▼]

Parkinson’s disease (PD) is the second most common neurodegenerative disease. Brain neuroinflammation plays a role in PD pathogenesis. However, the involvement of the peripheral immune system has not been systematically investigated. Here we analyzed >700 combinatorial immunological features in fresh blood of 28 early-to-mid-stage PD patients and 24 matched controls. We found an enhanced cytotoxic immune profile in idiopathic PD patients (iPD), with a higher frequency of terminally-differentiated effector CD8 T (TEMRA), late-differentiated CD8+ natural killer T cells and neutrophils. This immune profile was intensified by elevated serum granzyme A, reduced percentages of CD8+FOXP3+ regulatory T cells and group 2 innate lymphoid cells with immunosuppressive or tolerance-inducing functions. The frequency of CD8 TEMRA was negatively correlated with disease duration, suggesting a contribution to PD pathogenesis. Our work provides a comprehensive map on disturbed peripheral adaptive and innate immune cells in early-to-mid iPD, proposing easily-accessible candidates for early diagnosis and treatments. [less ▲]

Detailed reference viewed: 39 (4 UL)
Full Text
See detailArbeitnehmer in Luxemburg wünschen sich verstärkt eine Reduktion ihrer vertraglichen Arbeitszeit
Sischka, Philipp UL; Steffgen, Georges UL

E-print/Working paper (2022)

Im Rahmen dieser Newsletter wird aufgezeigt, wie sich die gewünschte Wochenarbeitszeit von Arbeitnehmern sowie die Differenz zwischen gewünschter Wochenarbeitszeit und vertraglicher Wochenarbeitszeit in ... [more ▼]

Im Rahmen dieser Newsletter wird aufgezeigt, wie sich die gewünschte Wochenarbeitszeit von Arbeitnehmern sowie die Differenz zwischen gewünschter Wochenarbeitszeit und vertraglicher Wochenarbeitszeit in den vergangenen Jahren in Luxemburg entwickelt haben. Dabei zeigt sich, dass der Anteil an Arbeitnehmern, die gerne weniger arbeiten würden, zwischen 2018 und 2021 deutlich gestiegen ist (von 32,8% auf 43,9%). Die Arbeitnehmer, die gerne weniger pro Woche arbeiten würden, möchten im Durchschnitt etwa 8 Stunden weniger arbeiten. Diese Entwicklungen fallen jedoch differenziert nach verschiedenen Arbeitnehmer-Gruppen unterschiedlich aus. So wünschen sich Arbeitnehmer im Vergleich zu Arbeitnehmerinnen konstant eine längere Arbeitszeit. Differenziert nach Alter, sind es vor allem die ältesten Arbeitnehmer, die sich im Durchschnitt die kürzeste Wochenarbeitszeit wünschen. Arbeitnehmer, die gerne weniger arbeiten würden, berichten tendenziell auch über schlechtere Arbeitsbedingungen im Vergleich zu Arbeitnehmern, deren gewünschte Arbeitszeit mit ihrer vertraglichen Arbeitszeit übereinstimmt. Auch berichten Arbeitnehmer, die gerne weniger pro Woche arbeiten würden, über ein geringeres Wohlbefinden. [less ▲]

Detailed reference viewed: 34 (1 UL)
Full Text
See detailThe Geometry of Supersymmetry
Poncin, Norbert UL; Schouten, Sarah

E-print/Working paper (2022)

Detailed reference viewed: 50 (8 UL)
Full Text
See detailGenome-wide meta-analysis of over 29,000 people with epilepsy reveals 26 loci and subtype-specific genetic architecture
International League Against Epilepsy Consortium on Complex Epilepsies Krause, Roland; Landoulsi, Zied UL; May, Patrick UL et al

E-print/Working paper (2022)

Epilepsy is a highly heritable disorder affecting over 50 million people worldwide, of which about one-third are resistant to current treatments. Here, we report a trans-ethnic GWAS including 29,944 cases ... [more ▼]

Epilepsy is a highly heritable disorder affecting over 50 million people worldwide, of which about one-third are resistant to current treatments. Here, we report a trans-ethnic GWAS including 29,944 cases, stratified into three broad- and seven sub-types of epilepsy, and 52,538 controls. We identify 26 genome-wide significant loci, 19 of which are specific to genetic generalized epilepsy (GGE). We implicate 29 likely causal genes underlying these 26 loci. SNP-based heritability analyses show that common variants substantially close the missing heritability gap for GGE. Subtype analysis revealed markedly different genetic architectures between focal and generalized epilepsies. Gene-set analysis of GGE signals implicate synaptic processes in both excitatory and inhibitory neurons in the brain. Prioritized candidate genes overlap with monogenic epilepsy genes and with targets of current anti-seizure medications. Finally, we leverage our results to identify alternate drugs with predicted efficacy if repurposed for epilepsy treatment. [less ▲]

Detailed reference viewed: 73 (9 UL)
Full Text
See detailOptimal lockdown and vaccination policies to contain the spread of a mutating infectious disease
Prieur, Fabien; Ruan, Weihua; Zou, Benteng UL

E-print/Working paper (2022)

We develop a piecewise deterministic control model to study optimal lockdown and vaccination policies to manage a pandemic. Lockdown is modeled as an impulse control that allows the system to switch from ... [more ▼]

We develop a piecewise deterministic control model to study optimal lockdown and vaccination policies to manage a pandemic. Lockdown is modeled as an impulse control that allows the system to switch from one restriction regime of restrictions to another. Vaccination policy is a continuous control. Decisions are taken under the risk of mutations of the disease, with repercussions on the transmission rate. The decision maker follows a cost minimization objective. We first characterize the optimality conditions for impulse control and show how the prospect of a mutation affects the decision maker's choice by inducing her to anticipate the relative benefit of a regime change after a mutation has occurred. Under some parametric conditions, our problem admits infinitely many value functions. We show the existence of a minimum value function that is a natural candidate to the solution given the nature of the problem. Focusing on this specific value function, we finally study the features of the optimal policy, especially the timing of impulse control. We prove that uncertainty surrounding future \bad" vs. \good" mutation of the disease expedites vs. delays the adoption of lockdown measures. [less ▲]

Detailed reference viewed: 38 (12 UL)
Full Text
See detailDeep Learning for Ground and Non-ground Surface Separation: A Feature-based Semantic Segmentation Algorithm for Point Cloud Classification
Nurunnabi, Abdul Awal Md UL; Lindenbergh, Roderik; Teferle, Felix Norman UL

E-print/Working paper (2022)

Precise ground surface topography is crucial for 3D city analysis, digital terrain modeling, natural disaster monitoring, high-density map generation, and autonomous navigation to name a few. Deep ... [more ▼]

Precise ground surface topography is crucial for 3D city analysis, digital terrain modeling, natural disaster monitoring, high-density map generation, and autonomous navigation to name a few. Deep learning (DL; LeCun, et al., 2015), a division of machine learning (ML), has been achieving unparalleled success in image processing, and recently demonstrated a huge potential for point cloud analysis. This article presents a feature-based DL algorithm that classifies ground and non-ground points in aerial laser scanning point clouds. Recent advancements of remote sensing technologies make it possible digitizing the real world in a near automated fashion. LiDAR (Light Detection and Ranging) based point clouds that are a type of remotely sensed georeferenced data, providing detailed 3D information on objects and environment have been recognized as one of the most powerful means of digitization. Unlike imagery, point clouds are unstructured, sparse and of irregular data format which creates many challenges, but also provides huge opportunities for capturing geometric details of scanned surfaces with millimeter accuracy. Classifying and separating non-ground points from ground points largely reduce data volumes for consecutive analyses of either ground or non-ground surfaces, which consequently saves cost and labor, and simplifies further analysis. [less ▲]

Detailed reference viewed: 52 (1 UL)
Full Text
See detailA model-based approach to density estimation in sup-norm
Maillard, Guillaume UL

E-print/Working paper (2022)

Building on the l−estimators of Baraud, we define a general method for finding a quasi-best approximant in sup-norm to a target density p⋆ belonging to a given model m, based on independent samples drawn ... [more ▼]

Building on the l−estimators of Baraud, we define a general method for finding a quasi-best approximant in sup-norm to a target density p⋆ belonging to a given model m, based on independent samples drawn from distributions p⋆i which average to p⋆ (which does not necessarily belong to m). We also provide a general method for selecting among a countable family of such models. Both of these esti- mators satisfy oracle inequalities in the general setting. The quality of the bounds depends on the volume of sets C on which |f| is close to its maximum, where f = p − q for some p, q ∈ m (or p ∈ m and q ∈ m′, in the case of model selection). In particular, using piecewise polynomials on dyadic partitions of Rd, we recover optimal rates of convergence for classes of functions with anisotropic smoothness, with optimal depen- dence on semi-norms measuring the smoothness of p⋆ in the coordinate directions. Moreover, our method adapts to the anisotropic smoothness, as long as it is smaller than 1 plus the degree of the polynomials. [less ▲]

Detailed reference viewed: 23 (0 UL)
See detailJob Location Decisions and the Effect of Children on the Employment Gender Gap
Albanese, Andrea; Nieto, Adrián; Tatsiramos, Konstantinos UL

E-print/Working paper (2022)

Detailed reference viewed: 45 (3 UL)
Full Text
See detailMitochondrial DNA heteroplasmy distinguishes disease manifestation in PINK1- and PRKN-linked Parkinson's disease 2022.05.17.22275087
Trinh, Joanne; Hicks, Andrew A.; Koenig, Inke R. et al

E-print/Working paper (2022)

Biallelic mutations in PINK1 and PRKN cause recessively inherited Parkinson's disease (PD). Though some studies suggest that PINK1/PRKN monoallelic mutations may not contribute to risk, deep phenotyping ... [more ▼]

Biallelic mutations in PINK1 and PRKN cause recessively inherited Parkinson's disease (PD). Though some studies suggest that PINK1/PRKN monoallelic mutations may not contribute to risk, deep phenotyping assessment showed that PINK1 or PRKN monoallelic pathogenic variants were at a significantly higher rate in PD compared to controls. Given the established role of PINK1 and Parkin in regulating mitochondrial dynamics, we explored mitochondrial DNA (mtDNA) integrity and inflammation as potential disease modifiers in carriers of mutations in these genes. MtDNA integrity, global gene expression and serum cytokine levels were investigated in a large collection of biallelic (n=84) and monoallelic (n=170) carriers of PINK1/PRKN mutations, iPD patients (n=67) and controls (n=90). Affected and unaffected PINK1/PRKN monoallelic mutation carriers can be distinguished by heteroplasmic mtDNA variant load (AUC=0.83, CI:0.74-0.93). Biallelic PINK1/PRKN mutation carriers harbor more heteroplasmic mtDNA variants in blood (p=0.0006, Z=3.63) compared to monoallelic mutation carriers. This enrichment was confirmed in iPSC-derived and postmortem midbrain neurons from biallelic PRKN-PD patients. Lastly, the heteroplasmic mtDNA variant load was found to correlate with IL6 levels in PINK1/PRKN mutation carriers (r=0.57, p=0.0074). PINK1/PRKN mutations predispose individuals to mtDNA variant accumulation in a dose- and disease-dependent manner. MtDNA variant load over time is a potential marker of disease manifestation in PINK1/PRKN mutation carriers.Competing Interest StatementThe authors have declared no competing interest.Funding StatementThe authors wish to thank the many patients and their families who volunteered, and the efforts of the many clinical teams involved. Funding has been obtained from the German Research Foundation (ProtectMove; FOR 2488, GR 3731/5-1; SE 2608/2-1; KO 2250/7-1), the Luxembourg National Research Fund in the ATTRACT (Model-IPD, FNR9631103), NCER-PD (FNR11264123) and INTER programmes (ProtectMove, FNR11250962; MiRisk-PD, C17/BM/11676395, NB 4328/2-1), the BMBF (MitoPD), the Hermann and Lilly Schilling Foundation, the European Community (SysMedPD), the Canadian Institutes of Health Research (CIHR), Peter and Traudl Engelhorn Foundation. Initial studies in Tunisia on familial parkinsonism were in collaboration with Lefkos Middleton, Rachel Gibson, and the GlaxoSmithKline PD Programme Team (2002-2005). We would like to thank Dr Helen Tuppen from the Welcome Trust Centre for Mitochondrial Research, Newcastle University, UK for providing us with the plasmid p7D1. Moreover, this project was supported by the high throughput/high content screening platform and HPC facility at the Luxembourg Centre for Systems Biomedicine, and the University of Luxembourg.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:University of Lubeck Ethics CommitteeI confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesAll data produced in the present study are available upon reasonable request to the authors [less ▲]

Detailed reference viewed: 67 (3 UL)
Peer Reviewed
See detailErinnerungspolitik und –praxis in Luxemburg am Beispiel einer gegenwärtigen Kontroverse
Kmec, Sonja UL

E-print/Working paper (2022)

In September 2021, so-called stumbling blocks were set by a Luxembourg school class: four for Jewish people who were murdered in concentration camps and eleven for young men who were forcibly drafted into ... [more ▼]

In September 2021, so-called stumbling blocks were set by a Luxembourg school class: four for Jewish people who were murdered in concentration camps and eleven for young men who were forcibly drafted into the Wehrmacht and died in the war. The commemoration triggered a broadly received controversy, which this article aims to explain and contextualize. [less ▲]

Detailed reference viewed: 40 (3 UL)
Full Text
See detailInternship and Public History Training
Cauvin, Thomas UL

E-print/Working paper (2022)

Detailed reference viewed: 34 (6 UL)
Full Text
See detailCreating Public History Master Programs: International Guidelines
Cauvin, Thomas UL; Montt, Maria; Will, Stoutamire et al

E-print/Working paper (2022)

Detailed reference viewed: 209 (12 UL)
Full Text
See detailWhy and when coalitions split? An alternative analytical approach with an application to environmental agreements
Boucekkine, Raouf; Camacho, Carmen; Ruan, Weihua et al

E-print/Working paper (2022)

We use a parsimonious two-stage differential game setting where the duration of the first stage, the coalition stage, depends on the will of a particular player to leave the coalition through an explicit ... [more ▼]

We use a parsimonious two-stage differential game setting where the duration of the first stage, the coalition stage, depends on the will of a particular player to leave the coalition through an explicit timing variable. By specializing in a standard linear-quadratic environmental model augmented with a minimal constitutional setting for the coalition (payoff share parameter), we are able to analytically extract several nontrivial findings. Three key aspects drive the results: the technological gap as an indicator of heterogeneity across players, the constitution of the coalition and the intensity of the public bad (here, the pollution damage). We provide with a full analytical solution to the two-stage differential game. In particular, we characterize the intermediate parametric cases leading to optimal nite time splitting. A key characteristic of these finite-time-lived coalitions is the requirement of the payoff share accruing to the splitting country to be large enough. Incidentally, our two-stage differential game setting reaches the conclusion that splitting countries are precisely those which use to benefit the most from the coalition. Constraining the payoff share to be low by Constitution may lead to optimal everlasting coalitions only provided initial pollution is high enough, which may cover the emergency cases we are witnessing nowadays. [less ▲]

Detailed reference viewed: 111 (12 UL)
Full Text
Peer Reviewed
See detailSolvability of systems of invariant differential equations on H2 and beyond
Palmirotta, Guendalina UL; Olbrich, Martin UL

E-print/Working paper (2022)

We show how the Fourier transform for distributional sections of vector bundles over symmetric spaces of non-compact type G/K can be used for questions of solvability of systems of invariant differential ... [more ▼]

We show how the Fourier transform for distributional sections of vector bundles over symmetric spaces of non-compact type G/K can be used for questions of solvability of systems of invariant differential equations in analogy to Hörmander’s proof of the Ehrenpreis-Malgrange theorem. We get complete solvability for the hyperbolic plane H2 and partial results for products H^2 × · · · × H^2 and the hyperbolic 3-space H^3. [less ▲]

Detailed reference viewed: 48 (0 UL)
Full Text
See detailDoes (Re-)Entering the Labor Market at Advanced Ages Protect Against Cognitive Decline? A Panel-Matching Difference-in-differences Approach
Kim, Jung Hyun UL; Muniz-Terrera, Graciela; Leist, Anja UL

E-print/Working paper (2022)

While prolonged labor market participation becomes increasingly important in ageing societies, evidence of the impacts of entering or exiting work beyond age 65 on cognitive functioning is scarce. We ... [more ▼]

While prolonged labor market participation becomes increasingly important in ageing societies, evidence of the impacts of entering or exiting work beyond age 65 on cognitive functioning is scarce. We estimate these effects using panel-matching difference-in-differences with populationrepresentative panel datasets from South Korea and the United States. We compare countries and across socioeconomic characteristics. We find general positive effects of entering the labor market in South Korea, while only individuals with high assets in the US benefit from entering the labor market. Exiting the labor market does not result in changes in cognitive functioning in Korea but is followed by a cognitive decline in individuals with low assets in the US. Findings suggest that the benefits and disincentives from late-life labor status transitions on cognitive functioning vary between South Korea and the US and across socioeconomic groups. [less ▲]

Detailed reference viewed: 40 (4 UL)
Full Text
See detailDie Vielfalt der Sozialen Arbeit in Luxemburg und die Arbeitsmarktzahlen 2021
Böwen, Petra UL; Flammang, Manou Laure

E-print/Working paper (2022)

Dieser Newsletter beschreibt den Arbeitsmarkt der Sozialen Arbeit in Luxemburg 2021, gibt einen Überblick über die Berufsqualifikationen und die Vielfalt der Praxisfelder und spezifischen Arbeitsbereiche.

Detailed reference viewed: 109 (4 UL)
Full Text
See detailCNV-ClinViewer: Enhancing the clinical interpretation of large copy-number variants online
Macnee, Marie; Perez-Palma, Eduardo; Brünger, Tobias et al

E-print/Working paper (2022)

Purpose Large copy number variants (CNVs) can cause a heterogeneous spectrum of rare and severe disorders. However, most CNVs are benign and are part of natural variation in human genomes. CNV ... [more ▼]

Purpose Large copy number variants (CNVs) can cause a heterogeneous spectrum of rare and severe disorders. However, most CNVs are benign and are part of natural variation in human genomes. CNV pathogenicity classification, genotype-phenotype analyses, and therapeutic target identification are challenging and time-consuming tasks that require the integration and analysis of information from multiple scattered sources by experts. Methods We developed a web-application combining >250,000 patient and population CNVs together with a large set of biomedical annotations and provide tools for CNV classification based on ACMG/ClinGen guidelines and gene-set enrichment analyses. Results Here, we introduce the CNV-ClinViewer (https://cnv-ClinViewer.broadinstitute.org), an open-source web-application for clinical evaluation and visual exploration of CNVs. The application enables real-time interactive exploration of large CNV datasets in a user-friendly designed interface. Conclusion Overall, this resource facilitates semi-automated clinical CNV interpretation and genomic loci exploration and, in combination with clinical judgment, enables clinicians and researchers to formulate novel hypotheses and guide their decision-making process. Subsequently, the CNV-ClinViewer enhances for clinical investigators patient care and for basic scientists translational genomic research. [less ▲]

Detailed reference viewed: 152 (1 UL)
Full Text
See detailConserved patterns across ion channels correlate with variant pathogenicity and clinical phenotypes 2022.03.23.485339
Brünger, Tobias; Perez-Palma, Eduardo; Montanucci, Ludovica et al

E-print/Working paper (2022)

Clinically identified genetic variants in ion channels can be benign or cause disease by increasing or decreasing the protein function. Consequently, therapeutic decision-making is challenging without ... [more ▼]

Clinically identified genetic variants in ion channels can be benign or cause disease by increasing or decreasing the protein function. Consequently, therapeutic decision-making is challenging without molecular testing of each variant. Our biophysical knowledge of ion channel structures and function is just emerging, and it is currently not well understood which amino acid residues cause disease when mutated.We sought to systematically identify biological properties associated with variant pathogenicity across all major voltage and ligand-gated ion channel families. We collected and curated 3,049 pathogenic variants from hundreds of neurodevelopmental and other disorders and 12,546 population variants for 30 ion channel or channel subunits for which a high-quality protein structure was available. Using a wide range of bioinformatics approaches, we computed 163 structural features and tested them for pathogenic variant enrichment. We developed a novel 3D spatial distance scoring approach that enables comparisons of pathogenic and population variant distribution across protein structures.We discovered and independently replicated that several pore residue properties and proximity to the pore axis were most significantly enriched for pathogenic variants compared to population variants. Using our novel 3D scoring approach, we showed that the strongest pathogenic variant enrichment was observed for pore-lining residues and alpha-helix residues within 5 A distance from the pore axis center and not involved in gating. Within the subset of residues located at the pore, the hydrophobicity of the pore was the feature most strongly associated with variant pathogenicity. We also found an association between the identified properties and both clinical phenotypes and fucntional in vitro assays for voltage-gated sodium channels (SCN1A, SCN2A, SCN8A) and N-methyl-D-aspartate (NMDA) receptor (GRIN1, GRIN2A, GRIN2B) encoding genes. In an independent expert-curated dataset of 1,422 neurodevelopmental disorder pathogenic patient variants, and 679 electrophysiological experiments that pore axis distance is associated with seizure age of onset and cognitive performance as well as differential gain vs. loss-of-channel function.In summary, we identified biological properties associated with ion-channel malfunction and show that these are correlated with in vitro functional read-outs and clinical phenotypes in patients with neurodevelopmental disorders. Our results suggest that clinical decision support algorithms that predict variant pathogenicity and function are feasible in the future.Competing Interest StatementThe authors have declared no competing interest.DSSPDictionary of Protein Secondary StructuregnomADGenome aggregation DatabaseGoFGain of functionGRIN genesGRIN1, GRIN2A. GRIN2BHGMDHuman Gene Mutation DatabaseNMDA receptorN-methyl-D-aspartate receptorGABA receptorGamma-aminobutyric acid receptorLoFLoss of functionSCN genesSCN1A, SCN2A, SCN8AVCFVariant Call Format [less ▲]

Detailed reference viewed: 29 (0 UL)
See detailPOTENTIAL METHOD AND PROJECTION THEOREMS FOR MACROSCOPIC HAUSDORFF DIMENSION
Daw, Lara UL; Seuret, Stephane

E-print/Working paper (2022)

Detailed reference viewed: 39 (2 UL)
Full Text
See detailEstimating a regression function in exponential families by model selection
Chen, Juntong UL

E-print/Working paper (2022)

Detailed reference viewed: 89 (28 UL)
Full Text
See detailPandemic Impacts on Sustainability and Hartwick’s Rule
Mavi, Can; Zou, Benteng UL

E-print/Working paper (2022)

In this study, we present a modified Hartwick rule encompassing the dynamics of pandemic, such as COVID-19. In our setting, the labor productivity gradually improves after the pandemic shock and may even ... [more ▼]

In this study, we present a modified Hartwick rule encompassing the dynamics of pandemic, such as COVID-19. In our setting, the labor productivity gradually improves after the pandemic shock and may even go beyond its pre-pandemic level due to the remote work and digitalization as also suggested by the empirical evidence. We demonstrate that a gradual labor productivity increase helps to conserve natural resources. We provide a theoretical foundation for a“sooner-the-better" strategy to control a pandemic, and we show that policy maker should implement a “whatever it costs” response to ensure that the transmission rate of the virus is below the recovery rate from the very beginning of the pandemic. Otherwise, the economy cannot have a sustained utility. We also analyze the implications of an “uncertain” pandemic on the intertemporal dynamics of natural resource and capital accumulation under the maximin criterion. Another important finding is that there exists a new economic and public health trade-off since a strong prevention policy is shown to decrease capital accumulation. [less ▲]

Detailed reference viewed: 75 (7 UL)
Full Text
See detailtrajeR, an R package for cluster analysis of time series
Noel, Cédric UL; Schiltz, Jang UL

E-print/Working paper (2022)

Detailed reference viewed: 33 (0 UL)
Full Text
Peer Reviewed
See detailDelorme’s intertwining conditions for sections of homogeneous vector bundles on two and three dimensional hyperbolic spaces
Palmirotta, Guendalina UL; Olbrich, Martin UL

E-print/Working paper (2022)

The description of the Paley-Wiener space for compactly supported smooth functions C_c^∞(G) on a semi-simple Lie group G involves certain intertwining conditions that are difficult to handle. In the ... [more ▼]

The description of the Paley-Wiener space for compactly supported smooth functions C_c^∞(G) on a semi-simple Lie group G involves certain intertwining conditions that are difficult to handle. In the present paper, we make them completely explicit for G = SL(2, R)^d (d ∈ N) and G = SL(2, C). Our results are based on a defining criterion for the Paley-Wiener space, valid for general groups of real rank one, that we derive from Delorme’s proof of the Paley-Wiener theorem. In a forthcoming paper, we will show how these results can be used to study solvability of invariant differential operators between sections of homogeneous vector bundles over the corresponding symmetric spaces. [less ▲]

Detailed reference viewed: 51 (0 UL)
Full Text
See detailRetransmission of broadcast signals by cable in hotels - An analysis of the EU CabSat-Directive in light of a pending CJEU case
Cole, Mark David UL

E-print/Working paper (2022)

It is well-known that the Court of Justice of the European Union (CJEU) has played a key role in giving the EU acquis in the area of intellectual property law the relevance it has today. Especially the ... [more ▼]

It is well-known that the Court of Justice of the European Union (CJEU) has played a key role in giving the EU acquis in the area of intellectual property law the relevance it has today. Especially the series of judgments clarifying the broad notion of “communication to the public” as laid down in form of an exclusive right in the so-called InfoSoc Directive 2001/29/EC with which the position of authors was significantly reinforced is an extensively debated and commented outcome. Until the recent addition of the DSM Copyright-Directive (EU) 2019/790 to the EU acquis with its inclusion of a press publisher’s right and increased obligations of platforms when they allow users to upload potentially copyrighted material, the InfoSoc Directive of 2001 has always been in the centre of attention. In the shadow of that Directive stands the so-called CabSat Directive 93/83/EEC , originally created in 1993 as supplementary action in order to ensure the realization of an EU-wide single market for television broadcasting which was initiated by the Television without Frontiers-Directive (TwFD) 89/552/EEC . The aim of the CabSat Directive was and remains the goal of ensuring that in the use of satellite distribution of broadcast programmes as well as retransmission by cable, rightholders’ positions are safeguarded and procedures respected that allow for a smooth realization of such use of broadcast signals. This Directive has only rarely been subject of preliminary reference requests by national courts. This makes a currently pending case highly relevant and gives the Court a unique opportunity to complement its case law on communication to the public for the specific aspect of retransmission of broadcasting signals: It has already in the ground-breaking decision of SGAE in 2006 clarified very firmly that the forwarding of broadcast signals – television programmes, notabene – by hotel operators to the individual rooms of a hotel and thereby offering the guests the possibility of individual access to the broadcast programmes constitutes a communication to the public. For such communication an authorization by the author(s) is needed and without such authorization it violates the exclusive right as laid down in Art. 3(1) InfoSoc Directive. While this has been settled concerning authors, the pending case of C-716/20 concerns exactly the same setup – a hotel operator picking up a satellite signal and disseminating it via cable to the hotel rooms – except that this time the questions to the court are asked through the lens of the CabSat Directive and the legal position of broadcasters vis-à-vis the hotel operators as provided for by the specific national law which transposed EU law. This contribution will therefore first explain the notion of ‘cable retransmission’ and in which parts of EU law it is laid down or referred to (II.). It will then give a more detailed look at the relevant provisions of the CabSat Directive and other related secondary law which establishes the framework for questions of cable retransmission and communication to the public (III.). Further, the case law of the CJEU will be analysed in order to identify those judgments that contribute to the clarification of the open question whether a retransmission by cable of a broadcast programme by hotel operators falls under the notion of cable retransmission as presented (IV.). As the actual question has not been answered by the Court in its jurisprudence so far, the main aspects of the pending preliminary proceedings will be explained without going into the details of the national proceedings of the previous instances, before the Portuguese Supremo Tribunal de Justiça (Supreme Court) decided to stay the proceedings and request from the CJEU a clarification of the EU law-related aspects. The criteria as developed will show – when applied to the case at hand – that the hotel operator needs to be qualified as an operator of a cable network conducting a cable retransmission (V.). Finally, in a concluding section the relevance of the outcome of this case will be discussed (VI.). [less ▲]

Detailed reference viewed: 58 (0 UL)
Full Text
Peer Reviewed
See detailFINCITY -- Excerpt from project description
Hesse, Markus UL; Dörry, Sabine; Sigler, Thomas

E-print/Working paper (2022)

Detailed reference viewed: 61 (1 UL)
Full Text
See detailTowards Generalizable Machine Learning for Chest X-ray Diagnosis with Multi-task learning
Ghamizi, Salah UL; Garcia Santa Cruz, Beatriz UL; Temple, Paul et al

E-print/Working paper (2022)

Clinicians use chest radiography (CXR) to diagnose common pathologies. Automated classification of these diseases can expedite analysis workflow, scale to growing numbers of patients and reduce healthcare ... [more ▼]

Clinicians use chest radiography (CXR) to diagnose common pathologies. Automated classification of these diseases can expedite analysis workflow, scale to growing numbers of patients and reduce healthcare costs. While research has produced classification models that perform well on a given dataset, the same models lack generalization on different datasets. This reduces confidence that these models can be reliably deployed across various clinical settings. We propose an approach based on multitask learning to improve model generalization. We demonstrate that learning a (main) pathology together with an auxiliary pathology can significantly impact generalization performance (between -10% and +15% AUC-ROC). A careful choice of auxiliary pathology even yields competitive performance with state-of-the-art models that rely on fine-tuning or ensemble learning, using between 6% and 34% of the training data that these models required. We, further, provide a method to determine what is the best auxiliary task to choose without access to the target dataset. Ultimately, our work makes a big step towards the creation of CXR diagnosis models applicable in the real world, through the evidence that multitask learning can drastically improve generalization. [less ▲]

Detailed reference viewed: 88 (15 UL)
See detailThe European Guarantee Fund and COVID-19: Agile But in Need of Greater Accountability
Howarth, David UL; Hodson, Dermot

E-print/Working paper (2022)

The European Guarantee Fund formed an important part of the EU’s first response to the COVID-19 pandemic. Despite delays from some member states and the European Commission over the creation of this ... [more ▼]

The European Guarantee Fund formed an important part of the EU’s first response to the COVID-19 pandemic. Despite delays from some member states and the European Commission over the creation of this instrument, the European Investment Bank (EIB) moved at high speed to support SMEs and mid-caps. The European Guarantee Fund was vertically accountable to national governments, but it needed stronger horizontal accountability to the European Parliament and diagonal accountability to NGOs. The EIB should commit to an independent ex-post evaluation of the European Guarantee Fund’s design, operation and impact. [less ▲]

Detailed reference viewed: 40 (0 UL)
Full Text
See detailDecentralised Finance's Unregulated Governance: Minority Rule in the Digital Wild West
Barbereau, Tom Josua UL; Smethurst, Reilly UL; Papageorgiou, Orestis UL et al

E-print/Working paper (2022)

Decentralised finance (DeFi) is a category of unlicensed, unregulated, and non-custodial financial services that utilise public, distributed ledgers like Ethereum. The Bloomberg Galaxy DeFi Index ... [more ▼]

Decentralised finance (DeFi) is a category of unlicensed, unregulated, and non-custodial financial services that utilise public, distributed ledgers like Ethereum. The Bloomberg Galaxy DeFi Index, launched in August 2021, includes nine Ethereum-based projects – non-custodial exchanges as well as lending and derivatives platforms. Each project is governed, at least in part, by a community of unregistered individuals that hold tradable voting rights tokens (also known as governance tokens). Voting rights tokens allow holders to vote on proposed changes to a DeFi project’s features, parameters, or rules. DeFi’s governance power is thus linked to the distribution and exercise of tokenised voting rights. Since DeFi projects are typically not managed by companies or public institutions, not much is known about DeFi’s governance. Regulators and law-makers from the United States recently asked if DeFi’s governance entails a new class of “shadowy” elites. In response, we conducted an exploratory, multiple-case study that focuses on the voting rights tokens issued by the nine projects from Bloomberg’s Galaxy DeFi index. Our mixed methods approach draws on Ethereum-based data about the distribution, trading, and staking of voting rights tokens, as well as project documentation and archival records. Our findings contribute knowledge about the entitlements of DeFi’s voting rights tokens, the initial distribution strategies, and the actual voting and delegation activity. Our principal finding is that DeFi’s voting rights are highly concentrated, and the exercise of these rights is very low. Our theoretical contribution is descriptive: minority rule is the probable consequence of tradable voting rights plus the lack of applicable anti-concentration or anti-monopoly laws. We interpret DeFi’s minority rule as timocratic and acknowledge its possible transition to oligarchy. [less ▲]

Detailed reference viewed: 17 (0 UL)
Full Text
See detailNimmt die Beschäftigungsqualität in Luxemburg ab?
Sischka, Philipp UL; Steffgen, Georges UL

E-print/Working paper (2022)

Im Rahmen dieser Newsletter wird aufgezeigt wie sich die verschiedenen Dimensionen der Beschäftigungsqualität in den vergangenen 6 Jahren in Luxemburg entwickelt haben. Dabei zeigt sich, dass die ... [more ▼]

Im Rahmen dieser Newsletter wird aufgezeigt wie sich die verschiedenen Dimensionen der Beschäftigungsqualität in den vergangenen 6 Jahren in Luxemburg entwickelt haben. Dabei zeigt sich, dass die Einkommenszufriedenheit und die wahrgenommenen Ausbildungsmöglichkeiten über die Zeit insgesamt eher abgenommen, und die Work-Life-Konflikte zugenommen haben. Diese Entwicklungen fallen differenziert nach verschiedenen Arbeitnehmer-Gruppen unterschiedlich aus. Beispielsweise haben Work-Life-Konflikte bei Arbeitnehmerinnen stärker zugenommen als bei Arbeitnehmern. Arbeitnehmer mit Kindern wiederum berichten im Vergleich zu Arbeitnehmer ohne Kinder über einen Rückgang der Beförderungsmöglichkeiten. Arbeitnehmer in staatlichen Organisationen weisen über die Zeit konstant höhere Werte bei Einkommenszufriedenheit, Ausbildungsmöglichkeiten und Arbeitsplatzsicherheit auf, im Vergleich zu Arbeitnehmern in privaten Unternehmen oder sonstigen Organisationen. Ergänzend zeigt sich, dass die Dimensionen der Beschäftigungsqualität mit verschiedenen Wohlbefindens-Dimensionen assoziiert sind. Insbesondere weisen höhere Work-Life-Konflikte Zusammenhänge mit geringerer Arbeitsmotivation, geringerer Arbeitszufriedenheit und geringerem generellem Well-Being, sowie erhöhtem Burnoutniveau und verstärkten Gesundheitsproblemen auf. [less ▲]

Detailed reference viewed: 16 (0 UL)
Full Text
Peer Reviewed
See detailClinically relevant combined effect of polygenic background, rare pathogenic germline variants, and family history on colorectal cancer incidence 2022.01.20.22269585
Hassanin, Emadeldin; Spier, Isabel; Bobbili, Dheeraj Reddy UL et al

E-print/Working paper (2022)

Background and aims: Summarised in polygenic risk scores (PRS), the effect of common, low penetrant genetic variants associated with colorectal cancer (CRC), can be used for risk stratification.Methods To ... [more ▼]

Background and aims: Summarised in polygenic risk scores (PRS), the effect of common, low penetrant genetic variants associated with colorectal cancer (CRC), can be used for risk stratification.Methods To assess the combined impact of the PRS and other main factors on CRC risk, 163,516 individuals from the UK Biobank were stratified as follows: 1. carriers status for germline pathogenic variants (PV) in CRC susceptibility genes (APC, MLH1, MSH2, MSH6, PMS2), 2. low (<20%), intermediate (20-80%), or high PRS (>80\%), and 3. family history (FH) of CRC. Multivariable logistic regression and Cox proportional hazards models were applied to compare odds ratios (OR) and to compute the lifetime incidence, respectively. Results: Depending on the PRS, the CRC lifetime incidence for non-carriers ranges between 6 and 22\%, compared to 40 and 74 for carriers. A suspicious FH is associated with a further increase of the cumulative incidence reaching 26 for non-carriers and 98 for carriers. In non-carriers without FH, but high PRS, the CRC risk is doubled, whereas a low PRS even in the context of a FH results in a decreased risk. The full model including PRS, carrier status, and FH improved the area under the curve (AUC) in risk prediction (0.704). Conclusion: The findings demonstrate that CRC risks are strongly influenced by the PRS for both a sporadic and monogenic background. FH, PV, and common variants complementary contribute to CRC risk. The implementation of PRS in routine care will likely improve personalized risk stratification, which will in turn guide tailored preventive surveillance strategies in high, intermediate, and low risk groups. [less ▲]

Detailed reference viewed: 78 (3 UL)
See detailSMART: a Technology Readiness Methodology in the Frame of the NIS Directive
Kumari, Archana; Schiffner, Stefan; Schmitz, Sandra UL

E-print/Working paper (2022)

Detailed reference viewed: 11 (0 UL)
Full Text
See detailDer Arbeitsmarkt der Sozialen Arbeit 2020 = Le marché de l'emploi du secteur social en 2020
Böwen, Petra UL; Flammang, Manou Laure UL

E-print/Working paper (2022)

Dieser Newsletter beschreibt den Arbeitsmarkt der Sozialen Arbeit in Luxemburg 2020 und die Entwicklung der Zahlen in einigen Bereichen für 2018 bis 2020. Die Daten stammen von einem fortlaufenden ... [more ▼]

Dieser Newsletter beschreibt den Arbeitsmarkt der Sozialen Arbeit in Luxemburg 2020 und die Entwicklung der Zahlen in einigen Bereichen für 2018 bis 2020. Die Daten stammen von einem fortlaufenden Forschungsprojekt des PraxisBüros der Universität Luxemburg. Der Newsletter stellt eine Auswahl an Statistiken dar, z.B. bezüglich der meist gefragten Qualifikationsniveaus, der Verteilung der Praxisfelder, der Verteilung der Stellenangebote zwischen öffentlichen, kommunalen, gemeinnützigen und privaten Trägern und der erfassten enormen Diskrepanz zwischen Nachfrage und Angebot an qualifizierten Professionellen in der Sozialen Arbeit. Desweiteren werden Entwicklungstrends- vor allem zu Thema Aus- und Weiterbildung aufgezeigt. [less ▲]

Detailed reference viewed: 824 (57 UL)
Full Text
See detailThe Irreversible Pollution Game
Boucekkine, Raouf; Ruan, Weihua; Zou, Benteng UL

E-print/Working paper (2022)

We study a 2-country differential game with irreversible pollution. Irresability is of a hard type: above a certain threshold level of pollution, the self-cleaning capacity of Nature drops to zero ... [more ▼]

We study a 2-country differential game with irreversible pollution. Irresability is of a hard type: above a certain threshold level of pollution, the self-cleaning capacity of Nature drops to zero. Accordingly, the game includes a non-concave feature, and we characterize both the cooperative and non-cooperative versions with this general non-LQ property. We deliver full analytical results for the existence of Markov Perfect Equilibria. We first demonstrate that when pollution costs are equal across players (symmetry), irreversible pollution regimes are more frequently reached than under cooperation. Second, we study the implications of asymmetry in the pollution cost. We find far nontrivial results on the reachability of the irreversible regime. However, we unambiguously prove that, for the same total cost of pollution, provided the irreversible regime is reached in both the symmetric and asymmetric cases, long-term pollution is larger in the symmetric case, reflecting more intensive free-riding under symmetry. [less ▲]

Detailed reference viewed: 113 (15 UL)
Full Text
See detailAn archaeal compound as a driver of Parkinson’s disease pathogenesis
Trezzi, Jean-Pierre; Aho, Velma UL; Jäger, Christian UL et al

E-print/Working paper (2022)

Patients with Parkinson’s disease (PD) exhibit differences in their gut microbiomes compared to healthy individuals. Although differences have most commonly been described in the abundances of bacterial ... [more ▼]

Patients with Parkinson’s disease (PD) exhibit differences in their gut microbiomes compared to healthy individuals. Although differences have most commonly been described in the abundances of bacterial taxa, changes to viral and archaeal populations have also been observed. Mechanistic links between gut microbes and PD pathogenesis remain elusive but could involve molecules that promote α-synuclein aggregation. Here, we show that 2-hydroxypyridine (2-HP) represents a key molecule for the pathogenesis of PD. We observe significantly elevated 2-HP levels in faecal samples from patients with PD or its prodrome, idiopathic REM sleep behaviour disorder (iRBD), compared to healthy controls. 2-HP is correlated with the archaeal species Methanobrevibacter smithii and with genes involved in methane metabolism, and it is detectable in isolate cultures of M. smithii. We demonstrate that 2-HP is selectively toxic to transgenic α-synuclein overexpressing yeast and increases α-synuclein aggregation in a yeast model as well as in human induced pluripotent stem cell derived enteric neurons. It also exacerbates PD-related motor symptoms, α-synuclein aggregation, and striatal degeneration when injected intrastriatally in transgenic mice overexpressing human α-synuclein. Our results highlight the effect of an archaeal molecule in relation to the gut-brain axis, which is critical for the diagnosis, prognosis, and treatment of PD. [less ▲]

Detailed reference viewed: 65 (4 UL)
Full Text
See detailTOWARDS A EUROPEAN SOCIAL TAXONOMY: A SCORECARD APPROACH
Bodellini, Marco UL

E-print/Working paper (2022)

Detailed reference viewed: 12 (2 UL)
Full Text
See detailOn Leopoldt's and Gross's defects for Artin representations
Maksoud, Alexandre UL

E-print/Working paper (2022)

We generalize Waldschmidt's bound for Leopoldt's defect and prove a similar bound for Gross's defect for an arbitrary extension of number fields. As an application, we prove new cases of the generalized ... [more ▼]

We generalize Waldschmidt's bound for Leopoldt's defect and prove a similar bound for Gross's defect for an arbitrary extension of number fields. As an application, we prove new cases of the generalized Gross conjecture (also known as the Gross-Kuz'min conjecture) beyond the classical abelian case, and we show that Gross's p-adic regulator has at least half of the conjectured rank. We also describe and compute non-cyclotomic analogues of Gross's defect. [less ▲]

Detailed reference viewed: 41 (0 UL)
Full Text
Peer Reviewed
See detailDLT-Based Enhancement of Cross-Border Payment Efficiency – a Legal and Regulatory Perspective
Zetzsche, Dirk Andreas UL; Anker-Sorensen, Linn; Passador, Maria et al

E-print/Working paper (2022)

Detailed reference viewed: 55 (4 UL)
Full Text
Peer Reviewed
See detailBuilding Regional Payment Areas: The Single Rule Book Approach
Zetzsche, Dirk Andreas UL; Lammer, Thomas; Gazi, S. et al

E-print/Working paper (2022)

Detailed reference viewed: 31 (0 UL)
Full Text
See detailFrom gravity to string topology
Merkoulov (merkulov), Serguei UL

E-print/Working paper (2022)

The chain gravity properad introduced earlier by the author acts on the cyclic Hochschild of any cyclic A∞ algebra equipped with a scalar product of degree −d. In particular, it acts on the cyclic ... [more ▼]

The chain gravity properad introduced earlier by the author acts on the cyclic Hochschild of any cyclic A∞ algebra equipped with a scalar product of degree −d. In particular, it acts on the cyclic Hochschild complex of any Poincare duality algebra of degree d, and that action factors through a quotient dg properad ST3−d of ribbon graphs which is in focus of this paper. We show that its cohomology properad H∙(ST3−d) is highly non-trivial and that it acts canonically on the reduced equivariant homology H¯S1∙(LM) of the loop space LM of any simply connected d-dimensional closed manifold M. By its very construction, the string topology properad H∙(ST3−d) comes equipped with a morphism from the gravity properad which is fully determined by the compactly supported cohomology of the moduli spaces Mg,n of stable algebraic curves of genus g with marked points. This result gives rise to new universal operations in string topology as well as reproduces in a unified way several known constructions: we show that (i) H∙(ST3−d) is also a properad under the properad of involutive Lie bialgebras in degree 3−d whose induced action on H¯S1∙(LM) agrees precisely with the famous purely geometric construction of M. Chas and D. Sullivan, (ii) H∙(ST3−d) is a properad under the properad of homotopy involutive Lie bialgebras in degree 2−d; (iii) E. Getzler's gravity operad injects into H∙(ST3−d) implying a purely algebraic counterpart of the geometric construction of C. Westerland establishing an action of the gravity operad on H¯S1∙(LM). [less ▲]

Detailed reference viewed: 63 (1 UL)
Full Text
See detailA restless badit approach for capacitated condition based maintenance scheduling
Demirci, Ece; Arts, Joachim UL; Van Houtum, Geert-Jan

E-print/Working paper (2022)

Detailed reference viewed: 110 (14 UL)
Full Text
See detailHomological projective duality for the Segre cubic
Beckmann, Thorsten; Belmans, Pieter UL

E-print/Working paper (2022)

The Segre cubic and Castelnuovo-Richmond quartic are two projectively dual hypersurfaces in P^4, with a long and rich history starting in the 19th century. We will explain how Kuznetsov's theory of ... [more ▼]

The Segre cubic and Castelnuovo-Richmond quartic are two projectively dual hypersurfaces in P^4, with a long and rich history starting in the 19th century. We will explain how Kuznetsov's theory of homological projective duality lifts this projective duality to a relationship between the derived category of a small resolution of the Segre cubic and a small resolution of the Coble fourfold, the double cover of P^4 ramified along the Castelnuovo-Richmond quartic. Homological projective duality then provides a description of the derived categories of linear sections, which we will describe to illustrate the theory. The case of the Segre cubic and Coble fourfold is non-trivial enough to exhibit interesting behavior, whilst being easy enough to explain the general machinery in this special and very classical case. [less ▲]

Detailed reference viewed: 45 (2 UL)
Full Text
Peer Reviewed
See detailA topological Paley-Wiener-Schwartz Theorem for sections of homogeneous vector bundles on G/K
Palmirotta, Guendalina UL; Olbrich, Martin UL

E-print/Working paper (2022)

We study the Fourier transform for compactly supported distributional sections of complex homogeneous vector bundles on symmetric spaces of non-compact type X = G/K. We prove a characterisation of their ... [more ▼]

We study the Fourier transform for compactly supported distributional sections of complex homogeneous vector bundles on symmetric spaces of non-compact type X = G/K. We prove a characterisation of their range. In fact, from Delorme’s Paley-Wiener theorem for compactly supported smooth functions on a real reductive group of Harish-Chandra class, we deduce topological Paley-Wiener and Paley-Wiener- Schwartz theorems for sections. [less ▲]

Detailed reference viewed: 58 (7 UL)
Full Text
See detailFiefs des comtes de Luxembourg au 13e siècle (Grande Région SaarLorLux)
Moulin, Philippe; Helfer, Malte UL; Pauly, Michel UL et al

E-print/Working paper (2022)

This map is an attempt at a cartographic representation of the active fiefs of the Counts of Luxembourg between 1200 and 1310. The map is intended to visualise the presence, frequency and type of feudal ... [more ▼]

This map is an attempt at a cartographic representation of the active fiefs of the Counts of Luxembourg between 1200 and 1310. The map is intended to visualise the presence, frequency and type of feudal estates of the Counts of Luxembourg. [less ▲]

Detailed reference viewed: 38 (3 UL)
Full Text
See detailWavelet methods to study the pointwise regularity of the generalized Rosenblatt process
Daw, Lara UL; Loosveldt, Laurent UL

E-print/Working paper (2022)

We prove that we can identify three types of pointwise behaviour in the regularity of the (generalized) Rosenblatt process. This extends to a non Gaussian setting previous results known for the ... [more ▼]

We prove that we can identify three types of pointwise behaviour in the regularity of the (generalized) Rosenblatt process. This extends to a non Gaussian setting previous results known for the (fractional) Brownian motion. On this purpose, fine bounds on the increments of the Rosenblatt process are needed. Our analysis is essentially based on various wavelet methods. [less ▲]

Detailed reference viewed: 67 (18 UL)
Full Text
See detailAn a posteriori error estimator for the spectral fractional power of the Laplacian
Bulle, Raphaël UL; Barrera, Olga; Bordas, Stéphane UL et al

E-print/Working paper (2022)

We develop a novel a posteriori error estimator for the L2 error committed by the finite ele- ment discretization of the solution of the fractional Laplacian. Our a posteriori error estimator takes ... [more ▼]

We develop a novel a posteriori error estimator for the L2 error committed by the finite ele- ment discretization of the solution of the fractional Laplacian. Our a posteriori error estimator takes advantage of the semi–discretization scheme using a rational approximation which allows to reformulate the fractional problem into a family of non–fractional parametric problems. The estimator involves applying the implicit Bank–Weiser error estimation strategy to each parametric non–fractional problem and reconstructing the fractional error through the same rational approximation used to compute the solution to the original fractional problem. We provide several numerical examples in both two and three-dimensions demonstrating the effectivity of our estimator for varying fractional powers and its ability to drive an adaptive mesh refinement strategy. [less ▲]

Detailed reference viewed: 69 (3 UL)
Full Text
Peer Reviewed
See detailUnified treatment of Artin-type problems
Järviniemi, Olli; Perucca, Antonella UL

E-print/Working paper (2022)

Detailed reference viewed: 31 (2 UL)
Full Text
See detailRobust density estimation with the L1-loss. Applications to the estimation of a density on the line satisfying a shape constraint
Baraud, Yannick UL; Halconruy, Hélène UL; Maillard, Guillaume UL

E-print/Working paper (2022)

We solve the problem of estimating the distribution of presumed i.i.d.\ observations for the total variation loss. Our approach is based on density models and is versatile enough to cope with many ... [more ▼]

We solve the problem of estimating the distribution of presumed i.i.d.\ observations for the total variation loss. Our approach is based on density models and is versatile enough to cope with many different ones, including some density models for which the Maximum Likelihood Estimator (MLE for short) does not exist. We mainly illustrate the properties of our estimator on models of densities on the line that satisfy a shape constraint. We show that it possesses some similar optimality properties, with regard to some global rates of convergence, as the MLE does when it exists. It also enjoys some adaptation properties with respect to some specific target densities in the model for which our estimator is proven to converge at parametric rate. More important is the fact that our estimator is robust, not only with respect to model misspecification, but also to contamination, the presence of outliers among the dataset and the equidistribution assumption. This means that the estimator performs almost as well as if the data were i.i.d.\ with density $p$ in a situation where these data are only independent and most of their marginals are close enough in total variation to a distribution with density $p$. {We also show that our estimator converges to the average density of the data, when this density belongs to the model, even when none of the marginal densities belongs to it}. Our main result on the risk of the estimator takes the form of an exponential deviation inequality which is non-asymptotic and involves explicit numerical constants. We deduce from it several global rates of convergence, including some bounds for the minimax L1-risks over the sets of concave and log-concave densities. These bounds derive from some specific results on the approximation of densities which are monotone, convex, concave and log-concave. Such results may be of independent interest. [less ▲]

Detailed reference viewed: 66 (12 UL)
Full Text
See detailHow Patent Rights Affect University Science
Berge, Laurent; Doherr, Thorsten; Hussinger, Katrin UL

E-print/Working paper (2022)

Detailed reference viewed: 19 (5 UL)
Full Text
See detailA Conjecture of Coleman on the Eisenstein Family
Advocaat, Bryan UL; Kiming, Ian; Wiese, Gabor UL

E-print/Working paper (2022)

We prove for primes $p\ge 5$ a conjecture of Coleman on the analytic continuation of the family of modular functions $\frac{\Es_\k}{V(\Es_\k)}$ derived from the family of Eisenstein series $\Es_\k$. The ... [more ▼]

We prove for primes $p\ge 5$ a conjecture of Coleman on the analytic continuation of the family of modular functions $\frac{\Es_\k}{V(\Es_\k)}$ derived from the family of Eisenstein series $\Es_\k$. The precise, quantitative formulation of the conjecture involved a certain on $p$ depending constant. We show by an example that the conjecture with the constant that Coleman conjectured cannot hold in general for all primes. On the other hand, the constant that we give is also shown not to be optimal in all cases. The conjecture is motivated by its connection to certain central statements in works by Buzzard and Kilford, and by Roe, concerning the ``halo'' conjecture for the primes $2$ and $3$, respectively. We show how our results generalize those statements and comment on possible future developments. [less ▲]

Detailed reference viewed: 35 (2 UL)
Full Text
See detailSplitting fields of X^n-X-1 (particularly for n=5), prime decomposition and modular forms
Khare, Chandrashekhar; La Rosa, Alfio Fabio UL; Wiese, Gabor UL

E-print/Working paper (2022)

We study the splitting fields of the family of polynomials $f_n(X)= X^n-X-1$. This family of polynomials has been much studied in the literature and has some remarkable properties. Serre related the ... [more ▼]

We study the splitting fields of the family of polynomials $f_n(X)= X^n-X-1$. This family of polynomials has been much studied in the literature and has some remarkable properties. Serre related the function on primes $N_p(f_n)$, for a fixed $n \leq 4$ and $p$ a varying prime, which counts the number of roots of $f_n(X)$ in $\mathbb F_p$ to coefficients of modular forms. We study the case $n=5$, and relate $N_p(f_5)$ to mod $5$ modular forms over $\mathbb Q$, and to characteristic 0, parallel weight 1 Hilbert modular forms over $\mathbb Q(\sqrt{19 \cdot 151})$. [less ▲]

Detailed reference viewed: 42 (2 UL)
Full Text
See detailTHE EU SUSTAINABLE FINANCE FRAMEWORK IN LIGHT OF INTERNATIONAL STANDARDS
Bodellini, Marco UL

E-print/Working paper (2022)

Detailed reference viewed: 16 (1 UL)
Full Text
See detailTRADE SECRET PROTECTION AND R&D INVESTMENT OF FAMILY FIRMS
Hussinger, Katrin UL; Issah, Abdul-Basit UL

E-print/Working paper (2022)

Detailed reference viewed: 147 (6 UL)
Full Text
See detailDickman Approximation of weighted random sums in the Kolmogorov distance
Bhattacharjee, Chinmoy UL; Schulte, Matthias

E-print/Working paper (2022)

Detailed reference viewed: 12 (0 UL)
Full Text
See detailSOniCS: Develop intuition on biomechanical systems through interactive error controlled simulations
Mazier, Arnaud UL; El Hadramy, Sidaty; Brunet, Jean-Nicolas et al

E-print/Working paper (2022)

This new approach allows the user to experiment with model choices easily and quickly without requiring in-depth expertise, as constitutive models can be modified by one line of code only. This ease in ... [more ▼]

This new approach allows the user to experiment with model choices easily and quickly without requiring in-depth expertise, as constitutive models can be modified by one line of code only. This ease in building new models makes SOniCS ideal to develop surrogate, reduced order mod- els and to train machine learning algorithms for uncertainty quantification or to enable patient-specific simulations. SOniCS is thus not only a tool that facilitates the development of surgical training simulations but also, and perhaps more importantly, paves the way to increase the intuition of users or otherwise non-intuitive behaviors of (bio)mechanical systems. The plugin uses new developments of the FEniCSx project enabling au- tomatic generation with FFCx of finite element tensors such as the local residual vector and Jacobian matrix. We validate our approach with nu- merical simulations such as manufactured solutions, cantilever beams, and benchmarks provided by FEBio. We reach machine precision accuracy and demonstrate the use of the plugin for a real-time haptic simulation involv- ing a surgical tool controlled by the user in contact with a hyperelastic liver. We include complete examples showing the use of our plugin for sim- ulations involving Saint Venant-Kirchhoff, Neo-Hookean, Mooney-Rivlin, and Holzapfel Ogden anisotropic models as supplementary material. [less ▲]

Detailed reference viewed: 18 (0 UL)
Full Text
See detailThe Decay Vendor: Timing Medical Radioisotope Production to Meet a Fixed Delivery Schedule
Nguyen, Tiffany-Thao Ngoc UL; Arts, Joachim UL

E-print/Working paper (2022)

Over 85% of nuclear medicine procedures are conducted with Technetium-99m (Tc-99m), a decay product of Molybdenum-99 (Mo-99). Mo-99 has a half-life of 66.7 hours and is primarily produced by irradiating ... [more ▼]

Over 85% of nuclear medicine procedures are conducted with Technetium-99m (Tc-99m), a decay product of Molybdenum-99 (Mo-99). Mo-99 has a half-life of 66.7 hours and is primarily produced by irradiating uranium in a nuclear research reactor. Due to its continuous decay the alignment of the supply chain’s just-in-time processes are critical. We present a basic structure to model and analyze this unique type of perishable supply chain. We consider how to integrate a production timing decision with a fixed delivery schedule. The objective is to maximize the viable amount of Mo-99 that makes it to the delivery given a stochastic lead time and departure. We compare a naïve approach for determining a production time to a greedy heuristic and show significant improvement potential of 5% on average and up to 22% in our test bed. We also investigate how different delivery schedules allow more viable Mo-99 to reach market [less ▲]

Detailed reference viewed: 23 (6 UL)
Full Text
See detailbinny: an automated binning algorithm to recover high-quality genomes from complex metagenomic datasets 2021.12.22.473795
Hickl, Oskar UL; Teixeira Queiros, Pedro UL; Wilmes, Paul UL et al

E-print/Working paper (2021)

The reconstruction of genomes is a critical step in genome-resolved metagenomics as well as for multi-omic data integration from microbial communities. Here, we present binny, a binning tool that produces ... [more ▼]

The reconstruction of genomes is a critical step in genome-resolved metagenomics as well as for multi-omic data integration from microbial communities. Here, we present binny, a binning tool that produces high-quality metagenome-assembled genomes from both contiguous and highly fragmented genomes. Based on established metrics, binny outperforms existing state-of-the-art binning methods and finds unique genomes that could not be detected by other methods.binny uses k-mer-composition and coverage by metagenomic reads for iterative, non-linear dimension reduction of genomic signatures as well as subsequent automated contig clustering with cluster assessment using lineage-specific marker gene sets.When compared to five widely used binning algorithms, binny recovers the most near-complete (\>95 pure, \>90 complete) and high-quality (\>90 pure, \>70 complete) genomes from simulated data sets from the Critical Assessment of Metagenome Interpretation (CAMI) initiative, as well as from a real-world benchmark comprised of metagenomes from various environments. binny is implemented as Snakemake workflow and available from https://github.com/a-h-b/binny.Competing Interest StatementThe authors have declared no competing interest. [less ▲]

Detailed reference viewed: 120 (13 UL)
Full Text
See detailZwischen Denkmalschutz und kanonischem Recht. Die Debatte über die Umnutzung entweihter Kirchen
Pauly, Michel UL

E-print/Working paper (2021)

Beim Denkmalschutz von Kirchen wird das Mobiliar in den Kirchen, vom Gestühl bis zum liturgischen Gerät, leider nicht mitgeschützt. Ein ausführlichres Inventar und eine Vereinfachung der Rechtspraxis ... [more ▼]

Beim Denkmalschutz von Kirchen wird das Mobiliar in den Kirchen, vom Gestühl bis zum liturgischen Gerät, leider nicht mitgeschützt. Ein ausführlichres Inventar und eine Vereinfachung der Rechtspraxis drängen sich auf. [less ▲]

Detailed reference viewed: 42 (1 UL)