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See detailModerator: Discussion with Christoph Brüll
Venken, Machteld UL

Presentation (2022, July 14)

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See detailA Gaussian damage function combined with sliced finite-element meshing for damage detection
Schommer, Sebastian; Dakhili, Khatereh UL; Nguyen, Viet Ha et al

in Journal of Civil Structural Health Monitoring (2022)

Bridges are among the most important components of transportation systems. Timely damage detection of these structures not only ensures reliability but also prevents catastrophic failures. This paper ... [more ▼]

Bridges are among the most important components of transportation systems. Timely damage detection of these structures not only ensures reliability but also prevents catastrophic failures. This paper addresses the damage assessment of bridges based on model updating techniques. Artificial damage was introduced to a beam that was a part of a real prestressed concrete bridge. The magnitude of the damage was increased stepwise, and static loading experiments were conducted in each step. A linear Finite-Element (FE) model with solid elements that were clustered into slices was utilised. A Gaussian bell-shaped curve was used as a damage function to describe the crack location using only three parameters. The experiments focused on sagging under dead load. Damage identification was performed in two steps using a coarse and a refined model. Initially, the FE model with a coarse mesh was updated to approximately localise the damage. Then, the FE model is refined in the vicinity of the approximately localised damage, and damage identification was accurately achieved. The results show that after the second step, the maximum error value of damage localisation is less than 0.5%. This approach could be later used to detect small damages that are not visible. [less ▲]

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See detailThe relationship between COVID-19 countermeasures at the workplace and psychological well-being. Findings from a nationally representative sample of Luxembourgish employees
Sischka, Philipp UL; Schmidt, Alexander F.; Steffgen, Georges UL

in Current Psychology (2022)

The COVID-19 pandemic has massively changed people’s working lives all over the world. While various studies investigated the effects from pandemic-induced unemployment and telecommuting, there is a lack ... [more ▼]

The COVID-19 pandemic has massively changed people’s working lives all over the world. While various studies investigated the effects from pandemic-induced unemployment and telecommuting, there is a lack of research regarding the impact of workplace COVID-19 countermeasures on well-being and mental health for employees who are still working on site. Thus, the aim of the present study was to investigate the prevalence of workplace COVID-19 countermeasures in organizations in Luxembourg. A person-centered approach was applied in order to explore how employees’ psychological well-being and health (i.e., general psychological well-being, vigor, work satisfaction, work-related burnout, somatic complaints, fear of COVID-19 infection) are impacted by organizational countermeasures and whether there are certain employee groups that are less protected by these. Results of a latent class analysis revealed four different classes (Low level of countermeasures, Medium level of countermeasures, High level of countermeasures, High level of countermeasures low distance). Employees working in a healthcare setting were more likely than employees working in a non-healthcare setting to be members of the High level of countermeasures low distance class. Class membership was meaningfully associated with all well-being outcomes. Members of the High level of countermeasures class showed the highest level of well-being, whereas Members of the Low level of countermeasures class and the High level of countermeasures low distance class showed the lowest level of well-being. Policy makers and organizations are recommended to increase the level of COVID-19 countermeasures as an adjunctive strategy to prevent and mitigate adverse mental health and well-being outcomes during the COVID-19 pandemic. [less ▲]

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See detailJewish History and the Politics of Digitisation
Zaagsma, Gerben UL

Scientific Conference (2022, July 13)

This paper discusses the politics of Jewish Studies by focusing on the digitisation of Jewish cultural heritage and its effects for research into Jewish history(ies). In the past few years we have ... [more ▼]

This paper discusses the politics of Jewish Studies by focusing on the digitisation of Jewish cultural heritage and its effects for research into Jewish history(ies). In the past few years we have witnessed the emergence of what could be termed the critical turn in digital humanities with an increasing focus on how digital resources shape various parts of the research process and its outcomes. One aspect of that turn is more attention to digital source criticism and the politics of digitisation of cultural heritage. There are many aspects of digitisation that can be considered “political”, from selection for digitisation to modes of access to broader questions about the political aspects of infrastructure or ‘infrapolitics’. None of these is specific to our digital age nor to Jewish Studies, and historical context is crucially important.  This paper builds upon my recent reseach into the politics of digitisation and considers the case of Jewish Studies, framed within the broader context of the politics of heritage and its preservation. It set outs a number of broad parameters for discussion, with the aim to encourage further debate. Questions to be addressed include: what Jewish heritage is being digitised and which stories about the Jewish past can (and cannot) be told on its basis? Which players are involved in digitisation and how do both top-down national strategies and bottom-up community initiatives guide the process? How do memory politics influence selection processes? And how does transnational heritage fare in an age where many digitisation programs are nationally framed and funded? The paper will use the historical example of the digitisation of Yiddish heritage to illustrate these questions and provide a concrete example.  [less ▲]

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See detailOstbelgien als popkultureller Zwischenraum?
Brüll, Christoph UL

Presentation (2022, July 13)

Seit einigen Jahren hat die ostbelgische Regionalgeschichtsschreibung versucht, den von Philipp Ther geprägten Begriff des ‚Zwischenraums‘ für die Historiografie über diese belgisch-deutsche Grenzregion ... [more ▼]

Seit einigen Jahren hat die ostbelgische Regionalgeschichtsschreibung versucht, den von Philipp Ther geprägten Begriff des ‚Zwischenraums‘ für die Historiografie über diese belgisch-deutsche Grenzregion im 19. und 20. Jahrhundert fruchtbar zu machen. Diese konzeptionellen Überlegungen fanden ihren Niederschlag zunächst in der Buchreihe „Grenzerfahrungen. Eine Geschichte der Deutschsprachigen Gemeinschaft Belgiens“ und dann vor allem in der am C²DH entwickelten virtuellen Ausstellung www.zeitschichten.be (2020). Der erste Teil des Vortrags besteht aus einer Meta-Führung durch die zum 100. Jahrestag der Zugehörigkeit der Region zu Belgien entwickelte Online-Expo. In einem zweiten Schritt sollen auf der Grundlage einiger der darin genutzten Quellen Überlegungen dazu angestellt werden, ob sich die Geschichte Ostbelgiens auch als die eines popkulturellen Zwischenraums deuten lässt. Dabei standen der faktischen Hybridität der regionalen, ländlich geprägten Kultur oftmals von der Sehnsucht nach nationaler Eindeutigkeit geprägte Selbstzuschreibungen entgegen, die die Suche nach dem Platz der Ostbelgier in Belgien, zwischen Belgien und Deutschland und zwischen zwei großen westeuropäischen Sprachräumen widerspiegeln. [less ▲]

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See detailStudying the Parkinson's disease metabolome and exposome in biological samples through different analytical and cheminformatics approaches: a pilot study
Talavera Andujar, Begona UL; Aurich, Dagny UL; Aho, Velma UL et al

in Analytical and Bioanalytical Chemistry (2022)

Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease, with an increasing incidence in recent years due to the ageing population. Genetic mutations alone only explain <10% of PD ... [more ▼]

Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease, with an increasing incidence in recent years due to the ageing population. Genetic mutations alone only explain <10% of PD cases, while environmental factors, including small molecules, may play a significant role in PD. In the present work, 22 plasma (11 PD, 11 control) and 19 feces samples (10 PD, 9 control) were analyzed by non-target high resolution mass spectrometry (NT-HRMS) coupled to two liquid chromatography (LC) methods (reversed phase (RP) and hydrophilic interaction liquid chromatography (HILIC)). A cheminformatics workflow was optimized using open software (MS-DIAL and patRoon) and open databases (all public MSP-formatted spectral libraries for MS-DIAL, PubChemLite for Exposomics and the LITMINEDNEURO list for patRoon). Furthermore, five disease-specific databases and three suspect lists (on PD and related disorders) were developed, using PubChem functionality to identifying relevant unknown chemicals. The results showed that non-target screening with the larger databases generally provided better results compared with smaller suspect lists. However, two suspect screening approaches with patRoon were also good options to study specific chemicals in PD. The combination of chromatographic methods (RP and HILIC) as well as two ionization modes (positive and negative) enhanced the coverage of chemicals in the biological samples. While most metabolomics studies in PD have focused on blood and cerebrospinal fluid, we found a higher number of relevant features in feces, such as alanine betaine or nicotinamide, which can be directly metabolized by gut microbiota. This highlights the potential role of gut dysbiosis in PD development. [less ▲]

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See detailModeling and Control of Laser Wire Additive Manufacturing
Mbodj, Natago Guilé UL

Doctoral thesis (2022)

Metal Additive Manufacturing (MAM) offers many advantages such as fast product manufacturing, nearly zero material waste, prototyping of complex large parts and the automatization of the manufacturing ... [more ▼]

Metal Additive Manufacturing (MAM) offers many advantages such as fast product manufacturing, nearly zero material waste, prototyping of complex large parts and the automatization of the manufacturing process in the aerospace, automotive and other sectors. In the MAM, several parameters influence the product creation steps, making the MAM challenging. In this thesis, we modelize and control the deposition process for a type of MAM where a laser beam is used to melt a metallic wire to create the metal parts called the Laser Wire Additive Manufacturing Process (LWAM). In the dissertation, first, a novel parametric modeling approach is created. The goal of this approach is to use parametric product design features to simulate and print 3D metallic objects for the LWAM. The proposed method includes a pattern and the robot toolpath creation while considering several process requirements of LWAM, such as the deposition sequences and the robot system. This technique aims to develop adaptive robot toolpaths for a precise deposition process with nearly zero error in the product creation process. Second, a layer geometry (width and height) prediction model to improve deposition accuracy is proposed. A machine learning regression algorithm is applied to several experimental data to predict the bead geometry across layers. Furthermore, a neural network-based approach was used to study the influence of different deposition parameters, namely laser power, wire-feed rate and travel speed on bead geometry. The experimental results shows that the model has an error rate of (i.e., 2∼4%). Third, a physics-based model of the bead geometry including known process parameters and material properties was created. The model developed for the first time includes critical process parameters, the material properties and the thermal history to describe the relationship between the layer height with different process inputs (i.e., the power, the standoff distance, the temperature, the wire-feed rate and the travel speed). The numerical results show a match of the model with the experimental measurements. Finally, a Model Predictive Controller (MPC) was designed to keep the layer height trajectory constant, considering the constraints and the operating range of the parameters of the process inputs. The model simulation result shows an acceptable tracking of the reference height. [less ▲]

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See detailPresenter: Talking Borders, History and Digital Hermeneutics
Venken, Machteld UL

Presentation (2022, July 13)

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See detailDocteur
Iglesias González, Alba UL

Doctoral thesis (2022)

The last century has been characterized by the increasing presence of synthetic chemicals in human surroundings, with as consequence, the increasing exposure of individuals to a wide variety of chemical ... [more ▼]

The last century has been characterized by the increasing presence of synthetic chemicals in human surroundings, with as consequence, the increasing exposure of individuals to a wide variety of chemical substances on a regular basis. The Lancet Commission on Pollution and Health estimated that since synthetic chemicals started to be available for common use at the end of the 1940s, more than 140,000 new chemicals have been produced, including five thousand used globally in massive volume. In parallel, awareness of the adverse effects of pollutant mixtures, possibly more severe than single-chemical exposures, has drawn attention towards the need of multi-residue analytical methods to obtain the most comprehensive information on human chemical exposome. Human biomonitoring, consisting in the measurement of pollutants in biological matrices, provides information that integrates all the possible sources of exposure, and is specific to the subject the sample is collected from. For this purpose, hair appears as a particularly promising matrix to assess chemical exposure thanks to its multiple benefits. Hair enables to detect both parent chemicals and metabolites, it is suitable to investigate exposure to chemicals from different families, and allows the detection of persistent and non-persistent chemicals. Moreover, contrary to fluids such as urine and blood, which only give information on the short-term exposure and present great variability in chemical concentration, hair is representative of wider time windows that can easily cover several months. Children represent the most vulnerable part of the population, and exposure to pollutants at young ages has been associated with severe health effects during childhood, but also during the adult life. Nevertheless, most epidemiological studies investigating exposure to pollutants are still conducted on adults, and data on children remain much more limited. The present study named “Biomonitoring of children exposure to pollutants based on hair analysis” investigated the relevance of hair analysis for assessing children exposure to pollutants. In this study, 823 hair samples were collected from children and adolescents living in 9 different countries (Luxembourg, France, Spain, Uganda, Indonesia, Ecuador, Suriname, Paraguay and Uruguay), and 117 hair samples were also collected from French adults. All samples were analysed for the detection of 153 organic compounds (140 were pesticides, 4 PCBs, 7 BDEs and 2 bisphenols). Moreover, the hair samples of French adults and children were also analysed for the detection of polycyclic aromatic hydrocarbons (PAH) and their metabolites (n = 62), nicotine, cotinine and metals (n = 36). The results obtained here clearly demonstrated that children living in different geographical areas are simultaneously exposed to multiple chemicals from different chemical classes. Furthermore, the presence of persistent organic pollutants in all children, and not only in adults, suggests that exposure to these chemicals is still ongoing, although these chemicals were banned decades ago. In the sub-group of Luxembourgish children, information collected within questionnaires in parallel to hair sample collection allowed to identify some possible determinant of exposure, such as diet (organic vs conventional), residence area (urban vs countryside), and presence of pets at home. Moreover, results showed higher levels of concentration in younger children, and higher exposure of boys to non-persistent pesticides than girls, which could possibly be attributed to differences in metabolism, behaviour and gender-specific activities. Finally, the study also highlighted high level of similarity in the chemical exposome between children from the same family compared to the rest of the population. The present study strongly supports the use of hair analysis for assessing exposure to chemical pollutants, and demonstrates the relevance of multi-residue methods to investigate exposome. [less ▲]

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See detailDeciphering the role of colorectal cancer-associated bacteria in the fibroblast-tumor cell interaction
Karta, Jessica UL

Doctoral thesis (2022)

Dysbiosis is an imbalance in the gut microbiome that is often associated with inflammation and cancer. Several microbial species, such as Fusobacterium nucleatum, have been suggested to be involved in ... [more ▼]

Dysbiosis is an imbalance in the gut microbiome that is often associated with inflammation and cancer. Several microbial species, such as Fusobacterium nucleatum, have been suggested to be involved in colorectal cancer (CRC). To date, most studies have focused on the interaction between CRC-associated bacteria and tumor cells. However, the tumor microenvironment (TME) is composed of various types of cells, among which cancer-associated fibroblasts (CAFs), one of the most vital players in the TME. The interaction between CRC-associated bacteria and CAFs and especially the impact of their cross-talk on tumor cells, remains largely unknown. In this regard, this thesis investigated the interaction between a well described and accepted CRC-associated bacteria, Fusobacterium nucleatum, and CAFs and their subsequent effects on tumor progression in CRC. Our findings show that F.nucleatum binds to CAFs and induces phenotypic changes. F.nucleatum promotes CAFs to secrete several pro-inflammatory cytokines and membrane-associated proteases. Upon exposure with F.nucleatum, CAFs also undergo metabolic rewiring with higher mitochondrial ROS and lactate secretion. Importantly, F.nucleatum-treated CAFs increase the migration ability of tumor cells in vitro through secreted cytokines, among which CXCL1. Furthermore, the co-injection of F.nucleatum-treated CAFs with tumor cells in vivo leads to a faster tumor growth as compared to the co-injection of untreated CAFs with tumor cells. Taken together, our results show that CAFs are an important player in the gut microbiome-CRC axis. Targeting the CAF-microbiome crosstalk might represent a novel therapeutic strategy for CRC. [less ▲]

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See detailSoziale Kohäsion als Reflexionskonzept zur Wohnraumproblematik im Großherzogtum Luxemburg
Dujardin, Céline UL

in Baier, Florian; Borrmann, Stefan; Hefel, Johanna M. (Eds.) et al Europäische Gesellschaften zwischen Kohäsion und Spaltung. Rolle, Herausforderungen und Perspektiven Sozialer Arbeit (2022)

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See detailPresenter: Testimonies from the War
Venken, Machteld UL

Presentation (2022, July 11)

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See detailExploring the Institutionalisation of Science Diplomacy: A Comparison of German and Swiss Science and Innovation Centres
Epping, Elisabeth UL

Doctoral thesis (2022)

This thesis explains and investigates the development and the institutionalisation of Science and Innovation Centres (SICs) as being distinct instruments of science diplomacy. SICs are a unique and ... [more ▼]

This thesis explains and investigates the development and the institutionalisation of Science and Innovation Centres (SICs) as being distinct instruments of science diplomacy. SICs are a unique and underexplored instrument in the science diplomacy toolbox and they are increasingly being adopted by highly innovative countries. This research responds to a growing interest in the field. Science diplomacy is commonly understood as a distinct governmental approach that mobilises science for wider foreign policy goals, such as improving international relations. However, science diplomacy discourse is characterised by a weak empirical basis and driven by normative perspectives. This research responds to these shortcomings and aims to lift the smokescreen of science diplomacy by providing an insight into its governance while also establishing a distinctly actor-centred perspective. In order to achieve this, two distinct SICs, Germany’s Deutsche Wissenschafts- und Innovationshäuser (DWIH) and Switzerland’s Swissnex are closely analysed in an original comparative and longitudinal study. While SICs are just one instrument in the governmental toolbox for promoting international collaboration and competition, they are distinct due to their holistic set- up and their role as a nucleus for the wider research and innovation system they represent. Moreover, SICs appear to have the potential to create a significant impact, despite their limited financial resources. This thesis takes a historical development perspective to outline how these two SICs were designed as well as their gradual development and institutionalisation. The thesis further probes why actors participate in SICs by unpacking their differing rationales, developing a distinctly actor-centred perspective on science diplomacy. This study has been designed in an inductive and exploratory way to account for the novelty of the topic; the research findings are based on the analysis of 41 interviews and a substantial collection of documents. The study finds evidence that SICs developed as a response to wider societal trends, although these trends differed for the two case studies. Moreover, the development of SICs has been characterised by aspects such as timing, contingency and critical junctures. SICs are inextricably connected to their national contexts and mirror distinct system characteristics, such as governance arrangements or degree of actor involvement. These aspects were also seen as explaining the exact shape that SICs take. Furthermore, this study finds evidence of an appropriation of SICs by key actors, in line with their organisational interests. In the case of the DWIH, this impacted and even limited its (potential) design and ways of operating. However, the analysis of SICs’ appropriation also revealed a distinct sense of collectivity, which developed among actors in the national research and innovation ecosystem due to this joint instrument. The research findings reaffirm that science diplomacy is clearly driven by national interests, while further highlighting that the notion of science diplomacy and its governance (actors, rationales and instruments) can only be fully understood by analysing the national context. [less ▲]

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See detailTowards practical Genome-Wide Association Studies: Overview and Challenges
Pascoal, Túlio UL; Decouchant, Jérémie UL; Volp, Marcus UL

Scientific Conference (2022, July 11)

The popularization of large-scale federated Genome-Wide Association Study (GWAS) where multiple data owners share their genome data to conduct federated analytics uncovers new privacy issues that have ... [more ▼]

The popularization of large-scale federated Genome-Wide Association Study (GWAS) where multiple data owners share their genome data to conduct federated analytics uncovers new privacy issues that have remained unnoticed or not given proper attention. Indeed, as soon as a diverse type of interested parties (e.g., private or public biocenters and governmental institutions from around the globe) and individuals from heterogeneous populations are participating in cooperative studies, interdependent and multi-party privacy appear as crucial issues that are currently not adequately assessed. In fact, in federated GWAS environments, the privacy of individuals and parties does not depend solely on their own behavior anymore but also on others, because a collaborative environment opens new credible adversary models. For instance, one might want to tailor the privacy guarantees to withstand the presence of potentially colluding federation members aiming to violate other members' data privacy and the privacy deterioration that might occur in the presence of interdependent genomic data (e.g., due to the presence of relatives in studies or the perpetuation of previous genomic privacy leaks in future studies). In this work, we catalog and discuss the features, unsolved problems, and challenges to tackle toward truly end-to-end private and practical federated GWAS. [less ▲]

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See detailLimit theorems with Malliavin calculus and Stein's method
Garino, Valentin UL

Doctoral thesis (2022)

We use recent tools from stochastic analysis (such as Stein's method and Malliavin calculus) to study the asymptotic behaviour of some functionals of a Gaussien Field.

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See detailLURN: Luxembourg Ukrainian Researcher Network
Ganschow, Inna UL

Article for general public (2022)

The colloquium is organised by scientists from the Center for Contemporary and Digital History (C²DH), Professor Marten Düring and Research Scientist Inna Ganschow-Levandovitch, as well as Research ... [more ▼]

The colloquium is organised by scientists from the Center for Contemporary and Digital History (C²DH), Professor Marten Düring and Research Scientist Inna Ganschow-Levandovitch, as well as Research Facilitator Marina Laurent from the Faculty of Humanities, Social and Pedagogical Sciences (FHSE) of the University of Luxembourg. The honorary leader of the inaugural colloquium is invited professor of C²DH Volodymyr Nemchenko. The goal is to develop cooperation between the scientific communities of Luxembourg and Ukraine through building networks among fellows from Ukraine, as well as creating prospects for sustainable cooperation in the future. [less ▲]

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See detailEuropean Integration Studies through Oral History and Multimedia Research - Innovative methodologie and new content creation
Danescu, Elena UL

Presentation (2022, July 11)

Presentation of three study cases: 1.Oral Historyand MultimediaResearch–Project ‘’Pierre Werner and Europe’’ (2011-2017) 2.Collaborative Oral History Project –‘’Brexit Reality Portraits’’ (2021-2022) 3 ... [more ▼]

Presentation of three study cases: 1.Oral Historyand MultimediaResearch–Project ‘’Pierre Werner and Europe’’ (2011-2017) 2.Collaborative Oral History Project –‘’Brexit Reality Portraits’’ (2021-2022) 3.Oral History Research Project –‘’The role of women in European and international relations in Luxembourg (after the Second World War)’’ (2022-2025) [less ▲]

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See detailThe Interaction between HLA-DRB1 and Smoking in Parkinson's Disease Revisited
Domenighetti, Cloé; Douillard, Venceslas; Sugier, Pierre-Emmanuel et al

in Movement Disorders (2022)

Abstract Background Two studies that examined the interaction between HLA-DRB1 and smoking in Parkinson's disease (PD) yielded findings in opposite directions. Objective To perform a large-scale ... [more ▼]

Abstract Background Two studies that examined the interaction between HLA-DRB1 and smoking in Parkinson's disease (PD) yielded findings in opposite directions. Objective To perform a large-scale independent replication of the HLA-DRB1 × smoking interaction. Methods We genotyped 182 single nucleotide polymorphism (SNPs) associated with smoking initiation in 12 424 cases and 9480 controls to perform a Mendelian randomization (MR) analysis in strata defined by HLA-DRB1. Results At the amino acid level, a valine at position 11 (V11) in HLA-DRB1 displayed the strongest association with PD. MR showed an inverse association between genetically predicted smoking initiation and PD only in absence of V11 (odds ratio, 0.74, 95 confidence interval, 0.59–0.93, PInteraction = 0.028). In silico predictions of the influence of V11 and smoking-induced modifications of α-synuclein on binding affinity showed findings consistent with this interaction pattern. Conclusions Despite being one of the most robust findings in PD research, the mechanisms underlying the inverse association between smoking and PD remain unknown. Our findings may help better understand this association. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society [less ▲]

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See detailGRN Mutations Are Associated with Lewy Body Dementia
Reho, Paolo; Koga, Shunsuke; Shah, Zalak et al

in Movement Disorders (2022)

ABSTRACT Background Loss-of-function mutations in GRN are a cause of familial frontotemporal dementia, and common variants within the gene have been associated with an increased risk of developing ... [more ▼]

ABSTRACT Background Loss-of-function mutations in GRN are a cause of familial frontotemporal dementia, and common variants within the gene have been associated with an increased risk of developing Alzheimer's disease and Parkinson's disease. Although TDP-43-positive inclusions are characteristic of GRN-related neurodegeneration, Lewy body copathology has also been observed in many GRN mutation carriers. Objective The objective of this study was to assess a Lewy body dementia (LBD) case–control cohort for pathogenic variants in GRN and to test whether there is an enrichment of damaging mutations among patients with LBD. Methods We analyzed whole-genome sequencing data generated for 2591 European-ancestry LBD cases and 4032 neurologically healthy control subjects to identify disease-causing mutations in GRN. Results We identified six heterozygous exonic GRN mutations in seven study participants (cases: n = 6; control subjects: n = 1). Each variant was predicted to be pathogenic or likely pathogenic. We found significant enrichment of GRN loss-of-function mutations in patients with LBD compared with control subjects (Optimized Sequence Kernel Association Test P = 0.0162). Immunohistochemistry in three definite LBD cases demonstrated Lewy body pathology and TDP-43-positive neuronal inclusions. Conclusions Our findings suggest that deleterious GRN mutations are a rare cause of familial LBD. © 2022 International Parkinson Movement Disorder Society. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA. [less ▲]

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