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See detailCrafting On-Skin Interfaces: An Embodied Prototyping Journey
Restrepo-Villamizar, J.; Vos, S.; Verhagen, E. et al

in DIS 2021 - Proceedings of the 2021 ACM Designing Interactive Systems Conference: Nowhere and Everywhere (2021, May)

This pictorial presents a design exploration of On-Skin Interfaces for recreational running. By integrating principles of interaction design, art and psychology, we explore the design of unconventional ... [more ▼]

This pictorial presents a design exploration of On-Skin Interfaces for recreational running. By integrating principles of interaction design, art and psychology, we explore the design of unconventional interfaces that facilitate the intuitive understanding of biofeedback and physiological-related information. We explored how principles from agency and bodily ownership can be applied in the design of sport- related wearables. Through our embodied prototyping journey, we gained insights on the implications of using the skin as an interactive design material. We focused on diverse materiality explorations to uncover and highlight the possibilities and challenges of materializing both functional and appealing On-Skin Interfaces. We synthesize and refl on our theoretical and practical explorations and deliver actionable insights for this growing fi of bodily and unconventional interfaces. © 2021 Owner/Author. [less ▲]

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See detailCohort profile: DOLORisk Dundee: a longitudinal study of chronic neuropathic pain
Hébert, Harry L; Veluchamy, Abirami; Baskozos, Georgios et al

in BMJ Open (2021), 11(5),

Purpose: Neuropathic pain is a common disorder of the somatosensory system that affects 7%-10% of the general population. The disorder places a large social and economic burden on patients as well as ... [more ▼]

Purpose: Neuropathic pain is a common disorder of the somatosensory system that affects 7%-10% of the general population. The disorder places a large social and economic burden on patients as well as healthcare services. However, not everyone with a relevant underlying aetiology develops corresponding pain. DOLORisk Dundee, a European Union-funded cohort, part of the multicentre DOLORisk consortium, was set up to increase current understanding of this variation in onset. In particular, the cohort will allow exploration of psychosocial, clinical and genetic predictors of neuropathic pain onset. Participants: DOLORisk Dundee has been constructed by rephenotyping two pre-existing Scottish population cohorts for neuropathic pain using a standardised 'core' study protocol: Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS) (n=5236) consisting of predominantly type 2 diabetics from the Tayside region, and Generation Scotland: Scottish Family Health Study (GS:SFHS; n=20 221). Rephenotyping was conducted in two phases: a baseline postal survey and a combined postal and online follow-up survey. DOLORisk Dundee consists of 9155 participants (GoDARTS=1915; GS:SFHS=7240) who responded to the baseline survey, of which 6338 (69.2%; GoDARTS=1046; GS:SFHS=5292) also responded to the follow-up survey (18 months later). Findings to date: At baseline, the proportion of those with chronic neuropathic pain (Douleur Neuropathique en 4 Questions questionnaire score ≥3, duration ≥3 months) was 30.5% in GoDARTS and 14.2% in Generation Scotland. Electronic record linkage enables large scale genetic association studies to be conducted and risk models have been constructed for neuropathic pain. Future plans: The cohort is being maintained by an access committee, through which collaborations are encouraged. Details of how to do this will be available on the study website (http://dolorisk.eu/). Further follow-up surveys of the cohort are planned and funding applications are being prepared to this effect. This will be conducted in harmony with similar pain rephenotyping of UK Biobank. [less ▲]

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See detailMAANA: An Automated Tool for DoMAin-specific HANdling of Ambiguity
Ezzini, Saad UL; Abualhaija, Sallam UL; Arora, Chetan et al

in Companion Proceedings of the 43rd International Conference on Software Engineering (2021, May)

MAANA (in Arabic: “meaning”) is a tool for performing domain-specific handling of ambiguity in requirements. Given a requirements document as input, MAANA detects the requirements that are potentially ... [more ▼]

MAANA (in Arabic: “meaning”) is a tool for performing domain-specific handling of ambiguity in requirements. Given a requirements document as input, MAANA detects the requirements that are potentially ambiguous. The focus of MAANA is on coordination ambiguity and prepositional-phrase attachment ambiguity; these are two common ambiguity types that have been studied in the requirements engineering literature. To detect ambiguity, MAANA utilizes structural patterns and a set of heuristics derived from a domain-specific corpus. The generated analysis file after running the tool can be reviewed by requirements analysts. Through combining different knowledge sources, MAANA highlights also the requirements that might contain unacknowledged ambiguity. That is when the analysts understand different interpretations for the same requirement, without explicitly discussing it with the other analysts due to time constraints. This artifact paper presents the details of MAANA. MAANA is associated with the ICSE 2021 technical paper titled “Using Domain-specific Corpora for Improved Handling of Ambiguity in Requirements”. The tool is publicly available on GitHub and Zenodo. [less ▲]

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See detailConsiderations on Dynamic Pricing in Carsharing Operations
Giorgione, Giulio UL; Viti, Francesco UL

Scientific Conference (2021, May)

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See detailAn equilibrium model for Mobility-as-a-Service
Bandiera, Claudia UL; Connors, Richard UL; Viti, Francesco UL

Scientific Conference (2021, May)

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See detailA holding control strategy for diverging bus lines
Laskaris, Georgios; Rinaldi, Marco; Cats, Oded et al

in Transportation Research. Part C, Emerging Technologies (2021)

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See detailDas Archivieren der Pandemie: Rapid Response Collecting in Luxemburg
Zumthurm, Tizian UL

Article for general public (2021)

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See detailTrade-offs in phenotypic noise synchronize emergent topology to actively enhance transport in microbial environments
Dhar, Jayabrata UL; Thai, Le Phuong Anh UL; Ghoshal, Arkajyoti UL et al

E-print/Working paper (2021)

Phenotypic noise underpins homeostasis and fitness of individual cells. Yet, the extent to which noise shapes cell-to-population properties in microbial active matter remains poorly understood. By ... [more ▼]

Phenotypic noise underpins homeostasis and fitness of individual cells. Yet, the extent to which noise shapes cell-to-population properties in microbial active matter remains poorly understood. By quantifying variability in confluent \textit{E.coli} strains, we catalogue noise across different phenotypic traits. The noise, measured over different temperatures serving as proxy for cellular activity, spanned more than two orders of magnitude. The maximum noise was associated with the cell geometry and the critical colony area at the onset of mono-to-multilayer transition (MTMT), while the lower bound was set by the critical time of the MTMT. Our results, supported by a hydrodynamic model, suggest that a trade-off between the noise in the cell geometry and the growth rate can lead to the self-regulation of the MTMT timing. The MTMT cascades synchronous emergence of hydrodynamic fields, actively enhancing the micro-environmental transport. Our results highlight how interplay of phenotypic noise triggers emergent deterministic properties, and reveal the role of multifield topology--of the colony structure and hydrodynamics--to insulate confluent systems from the inherent noise associated with natural cell-environment settings. [less ▲]

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See detailOverview of the impact of the proposed EU Digital Services Act Package on broadcasting in Europe A legal issue paper concerning the main elements of the Commission proposals for a Digital Services Act (DSA) and a Digital Markets Act (DMA) from a media law perspective
Cole, Mark David UL

Report (2021)

A legal issue paper concerning the main elements of the Commission proposals for a Digital Services Act (DSA) and a Digital Markets Act (DMA) from a media law perspective

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See detailThe Impact of SARS-COVID-19 Outbreak on European Cities Urban Mobility
Vitello, Piergiorgio UL; Connors, Richard UL; Viti, Francesco UL

in Frontiers in Future Transportation (2021)

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See detailDJ-1 depletion slows down immunoaging in T-cell compartments
Zeng, Ni; Capelle, Christophe; Baron, Alexandre et al

Report (2021)

Decline in immune function during aging increases susceptibility to different aging related diseases. However, the underlying molecular mechanisms, especially the genetic factors contributing to imbalance ... [more ▼]

Decline in immune function during aging increases susceptibility to different aging related diseases. However, the underlying molecular mechanisms, especially the genetic factors contributing to imbalance of naïve/memory T-cell subpopulations, still remain largely elusive. Here we show that loss of DJ-1 encoded by PARK7 /DJ-1, causing early-onset familial Parkinson’s disease (PD), unexpectedly delayed immunoaging in both human and mice. Compared with two gender-matched unaffected sibling carriers of similar ages, the index PD patient with DJ-1 deficiency showed a decline in many critical immunoaging features, including almost doubled frequencies of non-senescent T cells. The observation of a ‘younger’ immune system in the index patient was further consolidated by the results in aged DJ-1 knockout mice. Our data from bone marrow chimera models and adoptive transfer experiments demonstrated that DJ-1 regulates several immunoaging features via hematopoietic-intrinsic and naïve-CD8-intrinsic mechanisms. Our finding suggests an unrecognized critical role of DJ-1 in regulating immunoaging, discovering a potent target to interfere with immunoaging- and aging-associated diseases. [less ▲]

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See detailOptimization in VHTS Satellite System Design with Irregular Beam Coverage for Non-Uniform Traffic Distribution
Ortiz Gomez, Flor de Guadalupe UL; Salas-Natera, Miguel A.; Martinez, Ramon et al

in Remote Sensing (2021), 13(13),

Very High Throughput Satellites (VHTS) have a pivotal role in complementing terrestrial networks to increase traffic demand. VHTS systems currently assume a uniform distribution of traffic in the service ... [more ▼]

Very High Throughput Satellites (VHTS) have a pivotal role in complementing terrestrial networks to increase traffic demand. VHTS systems currently assume a uniform distribution of traffic in the service area, but in a real system, traffic demands are not uniform and are dynamic. A possible solution is to use flexible payloads, but the cost of the design increases considerably. On the other hand, a fixed payload that uses irregular beam coverage depending on traffic demand allows maintaining the cost of a fixed payload while minimizing the error between offered and required capacity. This paper presents a proposal for optimizing irregular beams coverage and beam pattern, minimizing the costs per Gbps in orbit, the Normalized Coverage Error, and Offered Capacity Error per beam. We present the analysis and performance for the case study and compare it with a previous algorithm for a uniform coverage area. [less ▲]

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See detailDo we need artificial inventors?
Stierle, Martin UL

Article for general public (2021)

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See detailDas (vermeintliche) Verschwinden des Reparierens
Krebs, Stefan UL; Hoppenheit, Thomas UL

Presentation (2021, April 27)

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See detailDefining a Manageable, Dynamic Chemical Space for Exposomics
Schymanski, Emma UL

Scientific Conference (2021, April 27)

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See detailMulti-GNSS Slant Wet Delay Retrieval Using Multipath Mitigation Maps
Hunegnaw, Addisu UL; Ejigu, Yohannes Getachew; Teferle, Felix Norman UL et al

Scientific Conference (2021, April 24)

The conventional Global Navigation Satellite System (GNSS) processing is typically contaminated with errors due to atmospheric variabilities, such as those associated with the mesoscale phenomena. These ... [more ▼]

The conventional Global Navigation Satellite System (GNSS) processing is typically contaminated with errors due to atmospheric variabilities, such as those associated with the mesoscale phenomena. These errors are manifested in the parameter estimates, including station coordinates and atmospheric products. To enhance the accuracy of these GNSS products further, a better understanding of the local-scale atmospheric variability is necessary. As part of multi-GNSS processing, station coordinates, carrier phase ambiguities, orbits, zenith total delay (ZTD) and horizontal gradients are the main parameters of interest. Here, ZTD is estimated as the average zenith delay along the line-of-sight to every observed GNSS satellite mapped to the vertical while the horizontal gradients are estimated in NS and EW directions and provide a means to partly account for the azimuthally inhomogeneous atmosphere. However, a better atmospheric description is possible by evaluating the slant path delay (SPD) or slant wet delay (SWD) along GNSS ray paths, which are not resolved by ordinary ZTD and gradient analysis. SWD is expected to provide better information about the inhomogeneous distribution of water vapour that is disregarded when retrieving ZTD and horizontal gradients. Usually, SWD cannot be estimated directly from GNSS processing as the number of unknown parameters exceeds the number of observations. Thus, SWD is generally calculated from ZTD for each satellite and may be dominated by un-modelled atmospheric delays, clock errors, unresolved carrier-phase ambiguities and near-surface multipath scattering. In this work, we have computed multipath maps by stacking individual post-fit carrier residuals incorporating the signals from four GNSS constellations, i.e. BeiDou, Galileo, Glonass and GPS. We have selected a subset of global International GNSS Service (IGS) stations capable of multi-GNSS observables located in different climatic zones. The multipath effects are reduced by subtracting the stacked multipath maps from the raw post-fit carrier phase residuals. We demonstrate that the multipath stacking technique results in significantly reduced variations in the one-way post-fit carrier phase residuals. This is particularly evident for lower elevation angles, thus, producing a retrieval method for SWD that is less affected by site-specific multipath effects. We show a positive impact on SWD estimation using our multipath maps during increased atmospheric inhomogeneity as induced by severe weather events. [less ▲]

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See detailMolecular basis for higher affinity of SARS-CoV-2 spike RBD for human ACE2 receptor
Julián M. Delgado; Nalvi Duro; David M. Rogers et al

in Wiley (2021)

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See detailCheminformatics and the Exposome in Health and Disease
Schymanski, Emma UL; Aurich, Dagny UL

Scientific Conference (2021, April 10)

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