Last 7 days
Bookmark and Share    
Full Text
Peer Reviewed
See detailAutomatic Diagnosis of Bipolar Disorder Using Optical Coherence Tomography Data and Artificial Intelligence
Sanchez-Morla, Eva M.; Fuentes, Juan L.; Miguel-Jimenez et al

in Journal of Personalized Medicine (2021)

Background: The aim of this study is to explore an objective approach that aids the diagnosis of bipolar disorder (BD), based on optical coherence tomography (OCT) data which are analyzed using artificial ... [more ▼]

Background: The aim of this study is to explore an objective approach that aids the diagnosis of bipolar disorder (BD), based on optical coherence tomography (OCT) data which are analyzed using artificial intelligence. Methods: Structural analyses of nine layers of the retina were analyzed in 17 type I BD patients and 42 controls, according to the areas defined by the Early Treatment Diabetic Retinopathy Study (ETDRS) chart. The most discriminating variables made up the feature vector of several automatic classifiers: Gaussian Naive Bayes, K-nearest neighbors and support vector machines. Results: BD patients presented retinal thinning affecting most layers, compared to controls. The retinal thickness of the parafoveolar area showed a high capacity to discriminate BD subjects from healthy individuals, specifically for the ganglion cell (area under the curve (AUC) = 0.82) and internal plexiform (AUC = 0.83) layers. The best classifier showed an accuracy of 0.95 for classifying BD versus controls, using as variables of the feature vector the IPL (inner nasal region) and the INL (outer nasal and inner inferior regions) thickness. Conclusions: Our patients with BD present structural alterations in the retina, and artificial intelligence seem to be a useful tool in BD diagnosis, but larger studies are needed to confirm our findings. [less ▲]

Detailed reference viewed: 30 (1 UL)
Full Text
Peer Reviewed
See detailCholesteric Spherical Reflectors as Physical Unclonable Identifiers in Anti-counterfeiting
Arenas Correa, Monica Patricia UL; Demirci, Huseyin UL; Lenzini, Gabriele UL

in Journal of the Association for Computing Machinery (2021, August 17), 16

Detailed reference viewed: 22 (0 UL)
See detailUnemployment and working hours of women and men during the pandemic
Todorovic, Jelena; van Kerm, Philippe UL; Peluso, Eugenio UL

Report (2021)

Nearly all modern recessions have had one thing in common: men's employment has been affected significantly more than that of women. At least this was the case until 2020, with the recession caused by the ... [more ▼]

Nearly all modern recessions have had one thing in common: men's employment has been affected significantly more than that of women. At least this was the case until 2020, with the recession caused by the COVID-19 pandemic. Not only has it been unique in terms of its origin, but also in terms of its impact on the labour market: for the first time women were significantly more likely than men to be laid off, furloughed or to experience a reduction in working hours. This has led some economists to coin the term “shecession” (she + recession) to describe the recent economic downturn [less ▲]

Detailed reference viewed: 21 (0 UL)
Full Text
Peer Reviewed
See detailRole of S100A8/A9 for Cytokine Secretion, Revealed in Neutrophils Derived from ER-Hoxb8 Progenitors
Zhou, Yang UL; Hann, Justine UL; Schenten, Veronique UL et al

in International Journal of Molecular Sciences (2021)

S100A9, a Ca2+-binding protein, is tightly associated to neutrophil pro-inflammatory functions when forming a heterodimer with its S100A8 partner. Upon secretion into the extracellular environment, these ... [more ▼]

S100A9, a Ca2+-binding protein, is tightly associated to neutrophil pro-inflammatory functions when forming a heterodimer with its S100A8 partner. Upon secretion into the extracellular environment, these proteins behave like damage-associated molecular pattern molecules, which actively participate in the amplification of the inflammation process by recruitment and activation of pro-inflammatory cells. Intracellular functions have also been attributed to the S100A8/A9 complex, notably its ability to regulate nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activation. However, the complete functional spectrum of S100A8/A9 at the intracellular level is far from being understood. In this context, we here investigated the possibility that the absence of intracellular S100A8/A9 is involved in cytokine secretion. To overcome the difficulty of genetically modifying neutrophils, we used murine neutrophils derived from wild-type and S100A9-/- Hoxb8 immortalized myeloid progenitors. After confirming that differentiated Hoxb8 neutrophil-like cells are a suitable model to study neutrophil functions, our data show that absence of S100A8/A9 led to a dysregulation of cytokine secretion after lipopolysaccharide (LPS) stimulation. Furthermore, we demonstrate that S100A8/A9-induced cytokine secretion was regulated by the nuclear factor kappa B (NF-κB) pathway. These results were confirmed in human differentiated HL-60 cells, in which S100A9 was inhibited by shRNAs. Finally, our results indicate that the degranulation process could be involved in the regulation of cytokine secretion by S100A8/A9. [less ▲]

Detailed reference viewed: 64 (8 UL)
Full Text
Peer Reviewed
See detailFrom language policy to educational practices: early multilingual education in Luxembourg
Seele, Claudia; Kirsch, Claudine UL

Poster (2021, August 17)

Detailed reference viewed: 32 (0 UL)
Full Text
Peer Reviewed
See detailRobustness of Adversarial Images against Filters
Chitic, Ioana Raluca UL; Deridder, Nathan; Leprevost, Franck UL et al

in Optimization and Learning (2021), 1443

Detailed reference viewed: 65 (2 UL)
Full Text
Peer Reviewed
See detailIntelligent Reflecting Surface Enhanced Secure Transmission Against Both Jamming and Eavesdropping Attacks
Sun, Yifu; An, Kang; Luo, Junshan et al

in IEEE Transactions on Vehicular Technology (2021), 70(10, Oct. 2021), 11017-11022

Both the jammer and the eavesdropper pose severe threat to wireless communications due to the broadcast nature of wireless channels. In this paper, an intelligent reflecting surface (IRS) assisted secure ... [more ▼]

Both the jammer and the eavesdropper pose severe threat to wireless communications due to the broadcast nature of wireless channels. In this paper, an intelligent reflecting surface (IRS) assisted secure communication system is considered, where a base station (BS) wishes to reliably convey information to a user, in the presence of both a jammer and an eavesdropper whose channel state information (CSI) is not perfectly known. Specifically, we aim to maximize the system achievable rate by jointly designing the BS’s transmit beamforming and the IRS’s reflect beamforming with imperfect CSI, while limiting the information leakage to the potential eavesdropper. Due to the non-convexity and intractability of the original problem induced by the CSI uncertainty, we utilize the auxiliary variables and General Sign-Definiteness transformation to convert the original optimization problem into a tractable convex optimization problem, and then obtain the high-quality optimal solution by using the successive convex approximation and penalty convex concave procedure. Numerical simulations demonstrate the superiority of our proposed optimization algorithm compared with existing approaches, and also reveal the impact of key parameters on the achievable system performance. [less ▲]

Detailed reference viewed: 26 (1 UL)
Full Text
Peer Reviewed
See detailCharacterizing the Theory of Spreading Electric Vehicles in Luxembourg
Arababadi; Leyer, Stephan UL; Leyer, Stephan UL et al

in Sustainability (2021)

Detailed reference viewed: 39 (0 UL)
Full Text
Peer Reviewed
See detailQuantitative trait locus mapping identifies a locus linked to striatal dopamine and points to collagen IV alpha-6 chain as a novel regulator of striatal axonal branching in mice
Thomas, Melanie UL; Gui, Yujuan; Garcia, Pierre UL et al

in Genes, Brain, and Behavior (2021)

Dopaminergic neurons (DA neurons) are controlled by multiple factors, many involved in neurological disease. Parkinson's disease motor symptoms are caused by the demise of nigral DA neurons, leading to ... [more ▼]

Dopaminergic neurons (DA neurons) are controlled by multiple factors, many involved in neurological disease. Parkinson's disease motor symptoms are caused by the demise of nigral DA neurons, leading to loss of striatal dopamine (DA). Here, we measured DA concentration in the dorsal striatum of 32 members of Collaborative Cross (CC) family and their eight founder strains. Striatal DA varied greatly in founders, and differences were highly heritable in the inbred CC progeny. We identified a locus, containing 164 genes, linked to DA concentration in the dorsal striatum on chromosome X. We used RNAseq profiling of the ventral midbrain of two founders with substantial difference in striatal DA–C56BL/6 J and A/J—to highlight potential protein-coding candidates modulating this trait. Among the five differentially expressed genes within the locus, we found that the gene coding for the collagen IV alpha 6 chain (Col4a6) was expressed nine times less in A/J than in C57BL/6J. Using single cell RNA-seq data from developing human midbrain, we found that COL4A6 is highly expressed in radial glia-like cells and neuronal progenitors, indicating a role in neuronal development. Collagen IV alpha-6 chain (COL4A6) controls axogenesis in simple model organisms. Consistent with these findings, A/J mice had less striatal axonal branching than C57BL/6J mice. We tentatively conclude that DA concentration and axonal branching in dorsal striatum are modulated by COL4A6, possibly during development. Our study shows that genetic mapping based on an easily measured Central Nervous System (CNS) trait, using the CC population, combined with follow-up observations, can parse heritability of such a trait, and nominate novel functions for commonly expressed proteins. [less ▲]

Detailed reference viewed: 23 (2 UL)
Full Text
Peer Reviewed
See detailMassive MIMO under Double Scattering Channels: Power Minimization and Congestion Controls
Van Chien, Trinh; Ngo, Hien Quoc; Chatzinotas, Symeon UL et al

in IEEE Transactions on Wireless Communications (2021)

This paper considers a massive MIMO system under the double scattering channels. We derive a closed-form expression of the uplink ergodic spectral efficiency (SE) by exploiting the maximum-ratio combining ... [more ▼]

This paper considers a massive MIMO system under the double scattering channels. We derive a closed-form expression of the uplink ergodic spectral efficiency (SE) by exploiting the maximum-ratio combining technique with imperfect channel state information. We then formulate and solve a total uplink data power optimization problem that aims at simultaneously satisfying the required SEs from all the users with limited power resources. We further propose algorithms to cope with the congestion issue appearing when at least one user is served by lower SE than requested. Numerical results illustrate the effectiveness of our proposed power optimization. More importantly, our proposed congestion-handling algorithms can guarantee the required SEs to many users under congestion, even when the SE requirement is high. [less ▲]

Detailed reference viewed: 27 (1 UL)
Full Text
Peer Reviewed
See detailChronic primary pain in the COVID-19 pandemic: how uncertainty and stress impact on functioning and suffering
Meulders, Ann; Vlaeyen, Johan W S; Evers, Andrea W M et al

in Pain (2021)

Detailed reference viewed: 23 (0 UL)
Full Text
Peer Reviewed
See detailGuest Editorial: Space Information Networks: Technological Challenges, Design Issues, and Solutions
Xue, Kaiping; De Cola, Tomaso; Wei, David S.L. et al

in IEEE Network (2021), 35(4), 16-18

It has been expected that the space information networks (SIN), as an extension of the terrestrial network, would provide high-speed, high-capacity, global continuous communication, and data transmission ... [more ▼]

It has been expected that the space information networks (SIN), as an extension of the terrestrial network, would provide high-speed, high-capacity, global continuous communication, and data transmission services anywhere for anyone at any time. With rapid advances in relevant technologies (e.g., satellite miniaturization technology, reusable rocket launch technology, and semiconductor technology), low-orbit satellites, drones, and airships can be integrated into the SIN to supply more comprehensive network connectivity. The standard development organizations including 3GPP, ITU, and ETSI already starts corresponding standardization activities to support nonterrestrial networks in SIN. It can be foreseen that SIN will be expanded to provide not only telephone services but also various kinds of Internet services, and it is thus able to serve many more users with different demands. [less ▲]

Detailed reference viewed: 26 (1 UL)
Full Text
Peer Reviewed
See detailSecure Transmission in Massive MIMO System with Specular Component-based Beamforming and Artificial Noise over Ricean Fading Channel
Qu, Aiyan; Zhang, Xianyu; An, Kang et al

in IEEE Wireless Communications Letters (2021), 10(11, Nov. 2021),

This paper investigates the secure transmission in a multi-user massive MIMO system over Ricean fading channel in the presence of a multi-antenna eavesdropper. In order to reduce the system complexity and ... [more ▼]

This paper investigates the secure transmission in a multi-user massive MIMO system over Ricean fading channel in the presence of a multi-antenna eavesdropper. In order to reduce the system complexity and the channel estimation overhead, a low-complexity beamforming (BF) scheme using only the specular component is presented. Moreover, the generation of artificial noise (AN) is employed at the base station (BS) for additional security enhancement. Specifically, a tractable closedform lower bound for the achievable ergodic secrecy rate is derived. Furthermore, the optimal power allocation factor is obtained based on the asymptotic analysis to maximize the achievable ergodic secrecy rate. The analytical results reveal that the ergodic secrecy rate improves with the increase of Ricean K- factor and converges to a specific constant when increasing the number of antennas. The performance of the proposed scheme is evaluated through comprehensive simulations. [less ▲]

Detailed reference viewed: 21 (1 UL)
See detailOn the effects of income heterogeneity in monopolistically competitive markets”
Picard, Pierre M UL; Kichko, Sergey

Scientific Conference (2021, August)

This paper studies the e¤ects of income heterogeneity on monopolistically competitive product markets and welfare in the context of non-homothetic preferences. When richer individuals expenditures are ... [more ▼]

This paper studies the e¤ects of income heterogeneity on monopolistically competitive product markets and welfare in the context of non-homothetic preferences. When richer individuals expenditures are less sensitive to price change compared to poorer ones , a mean-preserving contraction of income distribution entices rms to charge higher prices, new rms enter and broaden product diversity. General equilibrium e¤ects have a negative impact on poorer individuals and, in speci c circumstances, on whole population. In open economies, lower income inequality in a country creates a price divergence between countries and decreases trade volumes and values. Those general equilibrium e¤ects are quantitatively non negligible. [less ▲]

Detailed reference viewed: 24 (2 UL)
See detailMedienwissenschaften und Mediendidaktik im Dialog. Zum Status Quoe von Medienbildung im Deutschunterricht
Dembeck, Till UL; Pavlik, Jennifer

Book published by Erich Schmidt (2021)

Detailed reference viewed: 32 (2 UL)
Full Text
Peer Reviewed
See detailBatching CSIDH Group Actions using AVX-512
Cheng, Hao UL; Fotiadis, Georgios UL; Groszschädl, Johann UL et al

in IACR Transactions on Cryptographic Hardware and Embedded Systems (TCHES) (2021, August), 2021(4), 618-649

Commutative Supersingular Isogeny Diffie-Hellman (or CSIDH for short) is a recently-proposed post-quantum key establishment scheme that belongs to the family of isogeny-based cryptosystems. The CSIDH ... [more ▼]

Commutative Supersingular Isogeny Diffie-Hellman (or CSIDH for short) is a recently-proposed post-quantum key establishment scheme that belongs to the family of isogeny-based cryptosystems. The CSIDH protocol is based on the action of an ideal class group on a set of supersingular elliptic curves and comes with some very attractive features, e.g. the ability to serve as a “drop-in” replacement for the standard elliptic curve Diffie-Hellman protocol. Unfortunately, the execution time of CSIDH is prohibitively high for many real-world applications, mainly due to the enormous computational cost of the underlying group action. Consequently, there is a strong demand for optimizations that increase the efficiency of the class group action evaluation, which is not only important for CSIDH, but also for related cryptosystems like the signature schemes CSI-FiSh and SeaSign. In this paper, we explore how the AVX-512 vector extensions (incl. AVX-512F and AVX-512IFMA) can be utilized to optimize constant-time evaluation of the CSIDH-512 class group action with the goal of, respectively, maximizing throughput and minimizing latency. We introduce different approaches for batching group actions and computing them in SIMD fashion on modern Intel processors. In particular, we present a hybrid batching technique that, when combined with optimized (8 × 1)-way prime-field arithmetic, increases the throughput by a factor of 3.64 compared to a state-of-the-art (non-vectorized) x64 implementation. On the other hand, vectorization in a 2-way fashion aimed to reduce latency makes our AVX-512 implementation of the group action evaluation about 1.54 times faster than the state-of-the-art. To the best of our knowledge, this paper is the first to demonstrate the high potential of using vector instructions to increase the throughput (resp. decrease the latency) of constant-time CSIDH. [less ▲]

Detailed reference viewed: 82 (10 UL)
Full Text
Peer Reviewed
See detailCreativity in Humans, Robots, Humbots
Lubart, Todd; Esposito, Dario; Gubenko, Alla UL et al

in Creativity: Theories – Research – Applications (2021), 8(1),

Detailed reference viewed: 52 (10 UL)
Full Text
Peer Reviewed
See detail"Unless One Does the Research, It May Seem as Just a Useless Battery-Consuming App" - Field Notes on COVID-19 Contact Tracing Applications
Stojkovski, Borce UL; Abu-Salma, Ruba; Triquet, Karen et al

in Digital Threats: Research and Practice (2021)

Globally, countries have been developing contact tracing applications to control the spread of the Coronavirus (COVID-19) disease. In this work, we present the findings of eight focus groups we conducted ... [more ▼]

Globally, countries have been developing contact tracing applications to control the spread of the Coronavirus (COVID-19) disease. In this work, we present the findings of eight focus groups we conducted with participants living in France and Germany, to explore why they decided to adopt, or not adopt, a contact tracing application as well as understand how they perceived the benefits/drawbacks and the threat model of a contact tracing application. [less ▲]

Detailed reference viewed: 30 (1 UL)