Prediction of Causal Candidate Genes in Coronary Artery Disease Loci.

in Arteriosclerosis, thrombosis, and vascular biology (2015), 35(10), 2207-17

OBJECTIVE: Genome-wide association studies have to date identified 159 significant and suggestive loci for coronary artery disease (CAD). We now report comprehensive bioinformatics analyses of sequence ... [more ▼]

OBJECTIVE: Genome-wide association studies have to date identified 159 significant and suggestive loci for coronary artery disease (CAD). We now report comprehensive bioinformatics analyses of sequence variation in these loci to predict candidate causal genes. APPROACH AND RESULTS: All annotated genes in the loci were evaluated with respect to protein-coding single-nucleotide polymorphism and gene expression parameters. The latter included expression quantitative trait loci, tissue specificity, and miRNA binding. High priority candidate genes were further identified based on literature searches and our experimental data. We conclude that the great majority of causal variations affecting CAD risk occur in noncoding regions, with 41% affecting gene expression robustly versus 6% leading to amino acid changes. Many of these genes differed from the traditionally annotated genes, which was usually based on proximity to the lead single-nucleotide polymorphism. Indeed, we obtained evidence that genetic variants at CAD loci affect 98 genes which had not been linked to CAD previously. CONCLUSIONS: Our results substantially revise the list of likely candidates for CAD and suggest that genome-wide association studies efforts in other diseases may benefit from similar bioinformatics analyses. [less ▲]

Renate Brosch and Kylie Crane, eds. Visualising Australia: Images, Icons, Imaginations.

in Journal for the Study of British Cultures (2015), 22(2), 131-134

Le Tableau des Différends de la Religion de Philippe de Marnix ou le testament d’un polémiste du XVIe siècle

Scientific Conference (2015)

Returns to Religion

in Shakespeare Jahrbuch (2015), 151

Visual Media as a Mode of Cultural Paradigms. On (Re-) presentation, Shaping and Scrutinizing Cultural Patterns inklusive eigenem Beitrag "Family Portraits as (Re-) Presentations of Cultural Paradigms. Tracing a Visual Frame of Reference through History"

Scientific Conference (2015)

Statistical Analysis of Child Marriage and Adolescent Pregnancy in Mozambique: Causes and Impact

Report (2015)

Why do SMEs file trademarks? Insights from firms in innovative industries

in Research Policy (2015), 44(10), 1915-1930

Trademark filings have increased markedly over time. Although prior research has investigated the out-comes of trademark registration, including its effects on firm market valuation and productivity ... [more ▼]

Trademark filings have increased markedly over time. Although prior research has investigated the out-comes of trademark registration, including its effects on firm market valuation and productivity, little isknown about why firms file trademarks. However, to interpret the increase in trademark filings and itseconomic effects, it is important to know and understand why firms file trademarks. Because trademarksare particularly important to small and medium-sized enterprises (SMEs), this study analyzes trademark-ing motives using a survey of 600 SMEs in innovative industries. An exploratory factor analysis yieldsthree distinct motives: protection, marketing, and exchange. A cluster analysis reveals four distinct clus-ters of firms with respect to the three trademarking motives. A comparison of these clusters revealssignificant differences in several industry- and firm-level characteristics, including participation in ser-vice industries and relationships with external parties. Implications for research on SMEs, trademarks,and intellectual property management are discussed. [less ▲]

L'industrie automobile dans la Grande Région SaarLorLux en 2011 - évolutions actuelles, défis et solutions possibles

E-print/Working paper (2015)

With almost 150,000 employees and more than 600 companies, the automotive industry is one of the most important sectors in the Greater Region. However, in the more recent past, globalisation ... [more ▼]

With almost 150,000 employees and more than 600 companies, the automotive industry is one of the most important sectors in the Greater Region. However, in the more recent past, globalisation, technological development and, above all, the global economic and financial crisis have had a strong influence on the sector and have posed challenges. This text attempts to review these developments and discuss possible strategies and measures to meet the challenges. [less ▲]

Développements et structures de la coopération trans-frontalière dans la Grande Région SaarLorLux

E-print/Working paper (2015)

In diesem Artikel werden die internationalen, interregionalen und grenznahen Strukturen der Zusammenarbeit in der Großregion SaarLorLux vorgestellt, die in den letzten Jahrzehnten entstanden sind. Die ... [more ▼]

In diesem Artikel werden die internationalen, interregionalen und grenznahen Strukturen der Zusammenarbeit in der Großregion SaarLorLux vorgestellt, die in den letzten Jahrzehnten entstanden sind. Die Untersuchung beginnt mit den späten 1960er Jahren, konzentriert sich dann auf die 1990er Jahre, in denen sich die grenzüberschreitende Zusammenarbeit innerhalb der EU stark entwickelte, und endet in den 2000er Jahren, in denen eine deutliche Konsolidierung der grenzüberschreitenden Zusammenarbeit zu verzeichnen ist. Alle Entwicklungen unterliegen den entsprechenden Rahmenbedingungen, die u.a. von Brüssel vorgegeben werden, und sind je nach Akteur unterschiedlich ausgeprägt. [less ▲]

The Archive As a Productive Space Of Conflict

Book published by Sternberg Press (2015)

The applied research project and publication The Archive as a Productive Space of Conflict deals with archival practice and its spatial repercussions. Inquiring whether any accumulation and organization ... [more ▼]

The applied research project and publication The Archive as a Productive Space of Conflict deals with archival practice and its spatial repercussions. Inquiring whether any accumulation and organization of knowledge is productive—to the effect that it generates a narrative and/or history—the project focuses specifically on archives becoming productive due to their spatial framework. Consequently, the project debates the conflicts that arise when the topological and architectural structure of archives overcome existing models of reservoirs and storage units. The project interrogates whether archives necessarily need to be exposed to spatial permanence, and, if so, what design framework has to be applied in order for those components to be able to take on more than a singular form of existence. [less ▲]