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See detailOn the Design of Sustainable Cities: Local Traffic Pollution and Urban Structure
Picard, Pierre M UL; Kyriakopoulou, Efthymia

in Journal of Environmental Economics and Management (2021), 107

This paper investigates the impact of local traffic pollution on the formation of residential and business districts. While firms benefit from local production externalities, households commute to their ... [more ▼]

This paper investigates the impact of local traffic pollution on the formation of residential and business districts. While firms benefit from local production externalities, households commute to their workplaces with private vehicles and exert a local pollution externality on the residents living along the urban transport networks. The spatial location of firms and residents endogenously results from the trade-off between the production and pollution externalities and the commuting costs. The analysis shows that in monocentric cities the benefits associated with a fall in per-vehicle pollution are absorbed by rents paid to absentee landlords. When a city includes business and residential districts as well as a district mixing both agents, a lower per-vehicle pollution enlarges the residential districts and shifts the business districts closer to the geographical center of the city. The paper finally studies the optimal city structure. The first-best policies that fully internalize the externalities still foster business agglomeration. [less ▲]

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See detailValue-oriented Legal Argumentation in Isabelle/HOL
Benzmüller, Christoph; Fuenmayor Pelaez, David UL

in International Conference on Interactive Theorem Proving (ITP-2021) - Proceedings (2021)

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See detailHeute sprechen. Literatur, Politik und andere Sprachen im Lied (Herder, Alunāns, Barons)
Dembeck, Till UL

in Interlitteraria (2021), 26(1), 3148

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See detailJongen a Meedercher ginn an de Schoulbicher ongläich duergestallt
Camposeo, Monica; Kerger, Sylvie UL

Speeches/Talks (2021)

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See detailiPSC-Derived Microglia as a Model to Study Inflammation in Idiopathic Parkinson's Disease.
Badanjak, Katja UL; Mulica, Patrycja UL; Smajic, Semra UL et al

in Frontiers in cell and developmental biology (2021), 9

Parkinson's disease (PD) is a neurodegenerative disease with unknown cause in the majority of patients, who are therefore considered "idiopathic" (IPD). PD predominantly affects dopaminergic neurons in ... [more ▼]

Parkinson's disease (PD) is a neurodegenerative disease with unknown cause in the majority of patients, who are therefore considered "idiopathic" (IPD). PD predominantly affects dopaminergic neurons in the substantia nigra pars compacta (SNpc), yet the pathology is not limited to this cell type. Advancing age is considered the main risk factor for the development of IPD and greatly influences the function of microglia, the immune cells of the brain. With increasing age, microglia become dysfunctional and release pro-inflammatory factors into the extracellular space, which promote neuronal cell death. Accordingly, neuroinflammation has also been described as a feature of PD. So far, studies exploring inflammatory pathways in IPD patient samples have primarily focused on blood-derived immune cells or brain sections, but rarely investigated patient microglia in vitro. Accordingly, we decided to explore the contribution of microglia to IPD in a comparative manner using, both, iPSC-derived cultures and postmortem tissue. Our meta-analysis of published RNAseq datasets indicated an upregulation of IL10 and IL1B in nigral tissue from IPD patients. We observed increased expression levels of these cytokines in microglia compared to neurons using our single-cell midbrain atlas. Moreover, IL10 and IL1B were upregulated in IPD compared to control microglia. Next, to validate these findings in vitro, we generated IPD patient microglia from iPSCs using an established differentiation protocol. IPD microglia were more readily primed as indicated by elevated IL1B and IL10 gene expression and higher mRNA and protein levels of NLRP3 after LPS treatment. In addition, IPD microglia had higher phagocytic capacity under basal conditions-a phenotype that was further exacerbated upon stimulation with LPS, suggesting an aberrant microglial function. Our results demonstrate the significance of microglia as the key player in the neuroinflammation process in IPD. While our study highlights the importance of microglia-mediated inflammatory signaling in IPD, further investigations will be needed to explore particular disease mechanisms in these cells. [less ▲]

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See detailSTV+Reductions: Towards Practical Verification of Strategic Ability Using Model Reductions
Kurpiewski, Damian; Pazderski, Witold; Jamroga, Wojciech UL et al

in Proceedings of AAMAS (2021)

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See detailImpact of model-agnostic nonconformity functions on efficiency of conformal classifiers: an extensive study
Aleksandrova, Marharyta UL; Chertov, Oleg

in Proceedings of Machine Learning Research (2021), 152

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See detailA Survey of Requirements for COVID-19 Mitigation Strategies
Jamroga, Wojciech UL; Mestel, David UL; Roenne, Peter UL et al

in Bulletin of The Polish Academy of Sciences: Technical Science (2021), 69(4), 137724

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See detailDie Mehrsprachigkeit der Prosa. Ein Kapitel aus Finnegans Wake
Dembeck, Till UL

in Dell’Anno, Sina; Imboden, Achim; Simon, Ralf (Eds.) et al Prosa: Theorie, Exegese, Geschichte (2021)

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See detailLieder verwerfen. Annäherungen an Oswald Eggers nihilum album
Dembeck, Till UL

in Endres, Martin; Simon, Ralf (Eds.) ‚Wort für Wort‘ – Lektüren zum Werk von Oswald Egger (2021)

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See detailEinleitung
Dembeck, Till UL; Pavlik, Jennifer

in Dembeck, Till; Pavlik, Jennifer (Eds.) Medienwissenschaften und Mediendidaktik im Dialog. Zum Status Quoe von Medienbildung im Deutschunterricht (2021)

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See detailLogics of Formal Inconsistency enriched with replacement: an algebraic and modal account
Carnielli, Walter; Coniglio, Marcelo; Fuenmayor Pelaez, David UL

in Review of Symbolic Logic (2021), online first

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See detailShort-Term Fluctuation of Subjective Age and its Correlates: An Ecological Momentary Assessment of Older Adults
Kornadt, Anna Elena UL; Pauly, Theresa; Gerstorf, Denis et al

in Innovation in Aging (2021), 5(Supplement_1), 287-287

We examined short-term fluctuations of subjective age with data obtained from 123 young-old (Mage = 67.19 years) and 47 old-old adults (Mage = 86.59 years) who reported their momentary subjective age six ... [more ▼]

We examined short-term fluctuations of subjective age with data obtained from 123 young-old (Mage = 67.19 years) and 47 old-old adults (Mage = 86.59 years) who reported their momentary subjective age six times a day over seven consecutive days as they were going about their everyday lives. Participants felt younger on a large majority of occasions, and 25% of the total variability in subjective age could be attributed to within-person variation. Those with younger trait subjective ages exhibited larger moment-to-moment variation, while chronological age did not impact variability. Furthermore, we investigated relationships between within-day fluctuations of subjective age and daily cortisol fluctuations. Our findings extend the literature on subjective age by showing that how old people feel can vary on a momentary basis, that state and trait components of subjective age are related, and that fluctuations in subjective age are related to biomarkers of stress. [less ▲]

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See detailDesigning Pareto optimal electricity retail rates when utility customers are prosumers
Saumweber, Andrea; Wederhake, Lars; Cardoso, Gonçalo et al

in Energy Policy (2021), 156

Electric retail rate design is relevant to utilities, customers, and regulators as retail rates impact the utility's revenue as well as the customers' electricity bills. In California, regulators approve ... [more ▼]

Electric retail rate design is relevant to utilities, customers, and regulators as retail rates impact the utility's revenue as well as the customers' electricity bills. In California, regulators approve rate proposals by privately owned vertical integrated utilities. Approval, however, is subject to compliance with multiple, potentially conflicting objectives such as economic or environmental objectives. Additionally, retail rates are price signals that affect how customers use electricity services. When utility customers change their usage, they also impact the ratemaking objectives to which rates have been designed. This suggests a feedback loop, which is particularly pronounced with prosumers, as they can systematically optimize their interactions with the electricity system. Prevalent ratemaking methods may not deliver retail rates that are optimal for multiple objectives when customers are prosumers. We propose a novel ratemaking method that formalizes the problem of designing retail rates as a multi-criteria optimization problem and accounts for prosumer reactions through a simulation-based optimization approach. Through a fictive case study, we found that the resulting Pareto frontiers are useful in recognizing and balancing tradeoffs among conflicting ratemaking objectives. Additionally, our results indicate that prevailing retail rates in California are not Pareto optimal. [less ▲]

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See detailThe Comprehensive Mindfulness Experience: A Typological Approach to the Potential Benefits of Mindfulness for Dealing with Motivational Conflicts
Grund, Axel UL; Senker, Kerstin; Dietrich, Julia et al

in Motivation Science (2021)

We wanted to address two critical limitations of research on mindfulness and motivational conflict, by (a) distinguishing between conflict experiences and conflict reactivity and (b) by applying a ... [more ▼]

We wanted to address two critical limitations of research on mindfulness and motivational conflict, by (a) distinguishing between conflict experiences and conflict reactivity and (b) by applying a typological approach, exploring natural combinations of two core qualities of (state) mindfulness: present moment awareness and a nonjudgmental stance. Using an experience-sampling (ES) design (N = 107 on the personal and 3862 at the observational level) with baseline and posttest measures of general affective wellbeing, we found that between-person differences in everyday conflict reactivity (i.e., perseverative and self-evaluative reactions toward conflict experiences) but not in conflict experiences per se (i.e., feeling that one wants to or should do something else) predicted impaired affective well-being after the ES period. Furthermore, multilevel latent profile analysis showed that momentary conflict reactivity was lowest when participants reported to be both momentarily aware and nonjudgmental, mirroring the comprehensive mindfulness experience. These effects existed while controlling for baseline and accompanying affect as well as for conflict intensity, strengthening the idea that motivational conflict itself is not a critical instance of self-regulation failure and that being mindful may contribute to remain functionally efficient and psychological well-adjusted. [less ▲]

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See detailSchool Alienation Among Adolescents in Switzerland and Luxembourg: The Role of Parent and Peer Supportive Attitudes Toward School and Teacher Autonomy Support
Morinaj, Julia; de Moll, Frederick UL; Hascher, Tina et al

in Youth and Society (2021), early online

Prior research has shown that socialization agents such as parents, peers, and teachers can play a significant role in adolescents’ educational outcomes, both through direct support or indirectly via ... [more ▼]

Prior research has shown that socialization agents such as parents, peers, and teachers can play a significant role in adolescents’ educational outcomes, both through direct support or indirectly via supportive attitudes that foster students’ bonding to school and academic motivation. However, less is known about the effects of parent and peer supportive attitudes and teacher autonomy support on unfavorable educational outcomes such as school alienation. This study investigated the role of socialization agents in the development of school alienation among 544 secondary school students in Switzerland and 535 secondary school students in Luxembourg in grades 7 to 9. Results of structural equation modeling showed that the role of socialization agents varies across the school alienation domains and educational contexts, with peers having the most substantial impact on all three domains of alienation in both countries. [less ▲]

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See detailOccurrence and Distribution of Pharmaceuticals and their Transformation Products in Luxembourgish Surface Waters
Singh, Randolph UL; Lai, Adelene UL; Krier, Jessy UL et al

E-print/Working paper (2021)

This pre-print describes the analysis of pharmaceuticals and their transformation products in surface water samples collected in Luxembourg from 2019 to 2020. Details of the experimental and computational ... [more ▼]

This pre-print describes the analysis of pharmaceuticals and their transformation products in surface water samples collected in Luxembourg from 2019 to 2020. Details of the experimental and computational tools and workflows used are fully described in the manuscript. Links to the suspect lists, codes used, and data files are also provided. [less ▲]

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See detailDiscovering Pesticides and their Transformation Products in Luxembourg Waters using Open Cheminformatics Approaches
Krier, Jessy UL; Singh, Randolph UL; Kondic, Todor UL et al

E-print/Working paper (2021)

Abstract The diversity of hundreds of thousands of potential organic pollutants and the lack of (publicly available) information about many of them is a huge challenge for environmental sciences ... [more ▼]

Abstract The diversity of hundreds of thousands of potential organic pollutants and the lack of (publicly available) information about many of them is a huge challenge for environmental sciences, engineering, and regulation. Suspect screening based on high-resolution liquid chromatography-mass spectrometry (LC-HRMS) has enormous potential to help characterize the presence of these chemicals in our environment, enabling the detection of known and newly emerging pollutants, as well as their potential transformation products (TPs). Here, suspect list creation (focusing on pesticides relevant for Luxembourg, incorporating data sources in 4 languages) was coupled to an automated retrieval of related TPs from PubChem based on high confidence suspect hits, to screen for pesticides and their TPs in Luxembourgish river samples. A computational workflow was established to combine LC-HRMS analysis and pre-screening of the suspects (including automated quality control steps), with spectral annotation to determine which pesticides and, in a second step, their related TPs may be present in the samples. The data analysis with Shinyscreen (https://git-r3lab.uni.lu/eci/shinyscreen/), an open source software developed in house, coupled with custom-made scripts, revealed the presence of 162 potential pesticide masses and 135 potential TP masses in the samples. Further identification of these mass matches was performed using the open source MetFrag (https://msbi.ipb-halle.de/MetFrag/). Eventual target analysis of 36 suspects resulted in 31 pesticides and TPs confirmed at Level-1 (highest confidence), and five pesticides and TPs not confirmed due to different retention times. Spatio-temporal analysis of the results showed that TPs and pesticides followed similar trends, with a maximum number of potential detections in July. The highest detections were in the rivers Alzette and Mess and the lowest in the Sûre and Eisch. This study (a) added pesticides, classification information and related TPs into the open domain, (b) developed automated open source retrieval methods - both enhancing FAIRness (Findability, Accessibility, Interoperability and Reusability) of the data and methods; and (c) will directly support “L’Administration de la Gestion de l’Eau” on further monitoring steps in Luxembourg. [less ▲]

Detailed reference viewed: 68 (3 UL)