Last 7 days
Bookmark and Share    
Full Text
See detailVaccination policies in Europe: a comparative study between selected countries” under the request, and for the benefit of, the Ministry of Health of the Government of the Grand Duchy of Luxembourg
Donati, Alessandra UL

Report (2021)

This report sets forth the main findings of the research that we carried out at the Max Planck Institute Luxembourg under the request, and for the benefit of, the Ministry of Health of Luxembourg.

Detailed reference viewed: 66 (1 UL)
Full Text
See detailThe Coronavirus Crisis in Europe: is this the time for the precautionary principle
Donati, Alessandra UL

in Utrilla, D.; Shabbir, A. (Eds.) EU law in times of pandemic, The EU’s legal response to Covid-19 (2021)

Detailed reference viewed: 35 (0 UL)
Full Text
Peer Reviewed
See detailEffective bending stiffness of steel-concrete composite columns with multiple encased steel profiles
Chrzanowski, M.; Odenbreit, Christoph UL; Obiala, R. et al

in Journal of constructional steel research (2021), 181

For the structural analysis of steel-concrete composite columns, Eurocode 4 allows only cross-sections with one implemented steel profile and double symmetry. However, there are worldwide more and more ... [more ▼]

For the structural analysis of steel-concrete composite columns, Eurocode 4 allows only cross-sections with one implemented steel profile and double symmetry. However, there are worldwide more and more examples of composite columns with more than one embedded steel profiles, like for example in the International Financial Center of Hong Kong and the Ping Anh Finance Center in Shenzhen. The common practice of analysis of such columns is to use the simple Euler-Bernoulli beam theory to describe the global behaviour. But recently, performed tests reveal that the resulting deformations exceed largely the deformations predicted by the aforementioned analytical model. The presented contribution shows a modified approach to analyse the stiffness of composite columns with multiple encased steel profiles. Based on the performed laboratory tests and numerical simulations with the finite element code Abaqus®, a new method to determine the effective stiffness is proposed. It combines a modified Timoshenko beam theory with embedded Vierendeel truss model – the VTBM model. This modified method leads to a reduced value of the effective stiffness, more realistic deformations at Ultimate Limit State and thus to a more realistic assessment of the Euler's critical buckling load. •Columns used in high-rise buildings are often out of the scope of design codes.•Separated steel cores in a column's cross-section leads to an innovative hypothesis.•Transition from the Euler-Bernoulli beam theory towards Vierendeel truss behaviour.•Vierendeel-like beam behaviour confirmed in tests and finite element simulations.•Proposed novel analytical model allows for a more accurate stability analysis. [less ▲]

Full Text
See detailDetection & Identification of On-Orbit Objects Using Machine Learning
Perez, Marcos; Mohamed Ali, Mohamed Adel UL; Garcia Sanchez, Albert UL et al

in European Conference on Space Debris (2021), 8(1),

Detailed reference viewed: 117 (12 UL)
Full Text
Peer Reviewed
See detailSPACECRAFT RECOGNITION LEVERAGING KNOWLEDGE OF SPACE ENVIRONMENT: SIMULATOR, DATASET, COMPETITION DESIGN, AND ANALYSIS
Mohamed Ali, Mohamed Adel UL; Gaudilliere, Vincent UL; Ghorbel, Enjie UL et al

in 2021 IEEE International Conference on Image Processing (ICIP) (2021)

Detailed reference viewed: 77 (16 UL)
Full Text
Peer Reviewed
See detailPower variations for fractional type infinitely divisible random fields
Basse-O'Connor, Andreas; Pilipauskaite, Vytauté UL; Podolskij, Mark UL

in Electronic Journal of Probability (2021), 26

Detailed reference viewed: 105 (3 UL)
Full Text
See detailThe Hidden Lattice Problem
Notarnicola, Luca UL; Wiese, Gabor UL

E-print/Working paper (2021)

We consider the problem of revealing a small hidden lattice from the knowledge of a low-rank sublattice modulo a given sufficiently large integer -- the {\em Hidden Lattice Problem}. A central motivation ... [more ▼]

We consider the problem of revealing a small hidden lattice from the knowledge of a low-rank sublattice modulo a given sufficiently large integer -- the {\em Hidden Lattice Problem}. A central motivation of study for this problem is the Hidden Subset Sum Problem, whose hardness is essentially determined by that of the hidden lattice problem. We describe and compare two algorithms for the hidden lattice problem: we first adapt the algorithm by Nguyen and Stern for the hidden subset sum problem, based on orthogonal lattices, and propose a new variant, which we explain to be related by duality in lattice theory. Following heuristic, rigorous and practical analyses, we find that our new algorithm brings some advantages as well as a competitive alternative for algorithms for problems with cryptographic interest, such as Approximate Common Divisor Problems, and the Hidden Subset Sum Problem. Finally, we study variations of the problem and highlight its relevance to cryptanalysis. [less ▲]

Detailed reference viewed: 46 (0 UL)
Full Text
Peer Reviewed
See detailParliamentary Scrutiny of Brexit in the EU-27 Pragmatic Cooperation with a Dominant European Parliament
Högenauer, Anna-Lena UL

in International Journal of Parliamentary Studies (2021), 1(2),

Concerns about a democratic deficit in the European Union reached new heights in recent years, as the organization has had to address a number of highly politicized challenges. In this context, the ... [more ▼]

Concerns about a democratic deficit in the European Union reached new heights in recent years, as the organization has had to address a number of highly politicized challenges. In this context, the question of how much oversight should be exercised by the European Parliament (ep) and national parliaments individually or collectively becomes increasingly salient. Against this background, this article argues that on the issue of Brexit the ep has been quick to carve out a role for itself. However, unlike in previous trade negotiations, national parliaments took a backseat on Brexit despite its potential impact on member states. This is largely due to the similarity of national and party positions on Brexit. In addition, the way the different interparliamentary bodies addressed Brexit reveals the limitations of these bodies in terms of their powers and the depth of their discussions. [less ▲]

Detailed reference viewed: 47 (5 UL)
Full Text
Peer Reviewed
See detailThe Data Use Ontology to streamline responsible access to human biomedical datasets
Lawson, Jonathan; Cabili, Moran N.; Kerry, Giselle et al

in Cell Genomics (2021), 1(2),

Detailed reference viewed: 35 (1 UL)
Full Text
Peer Reviewed
See detailGA4GH Passport standard for digital identity and access permissions
Voisin, Craig; Linden, Mikael; Dyke, Stephanie O. M. et al

in Cell Genomics (2021), 1(2),

Detailed reference viewed: 30 (0 UL)
Full Text
See detailUniversalité et rétroactivité en droit des sociétés
Conac, Pierre-Henri UL

in Mélanges en l’honneur du Professeur Gilbert Parleani (2021)

Detailed reference viewed: 37 (0 UL)
Full Text
See detailAustrian Limited: Die Pläne zur flexiblen Kapitalgesellschaft und die Reform des Gesellschaftsrechts
Conac, Pierre-Henri UL

in Der Gesellschafter (2021)

Der vorliegende Beitrag widmet sich der von der Regierung geplanten neuen Kapitalgesellschaftsform einer Austrian Limited.

Detailed reference viewed: 50 (1 UL)
Full Text
Peer Reviewed
See detailA geometrically nonlinear shear deformable beam model for piezoelectric energy harvesters
Shang, Lan UL; Hoareau, Christophe; Zilian, Andreas UL

in Acta Mechanica (2021), 232(12), 4847-4866

An electromechanical model for beam-like piezoelectric energy harvesters based on Reissner’s beam theory is developed in this paper. The proposed model captures first-order shear deformation and large ... [more ▼]

An electromechanical model for beam-like piezoelectric energy harvesters based on Reissner’s beam theory is developed in this paper. The proposed model captures first-order shear deformation and large displacement/rotation, which distinguishes this model from other models reported in the literature. All governing equations are presented in detail, making the associated framework extensible to investigate various piezoelectric energy harvesters. The weak formulation is then derived to obtain the approximate solution to the governing equations by the finite element method. This solution scheme is completely coupled, and thus allows for two-way interaction between mechanical and electrical fields. To validate this model, extensive numerical examples are implemented in the linear and nonlinear regime. In the linear limit, this model produces results in excellent agreement with reference data. In the nonlinear regime, the large amplitude response of the piezoelectric beam induced by strong base excitation or fluid flow is considered, and the comparison of results with literature data is encouraging. The ability of this nonlinear model to predict limit cycle oscillations in axial flow is demonstrated. [less ▲]

Full Text
See detailWie Castor und Pollux? Zur gegenseitigen Abhängigkeit von Geistes- und Naturwissenschaften
Binsfeld, Andrea UL; Pauly, Michel UL

in Baumann, Isabell Eva; Dembeck, Till; Mein, Georg (Eds.) et al The Ends of Humanities (2021)

Full Text
Peer Reviewed
See detailDCcov: Repositioning of drugs and drug combinations for SARS-CoV-2 infected lung through constraint-based modeling.
Kishk, Ali UL; Pires Pacheco, Maria Irene UL; Sauter, Thomas UL

in iScience (2021), 24(11), 103331

The 2019 coronavirus disease (COVID-19) became a worldwide pandemic with currently no approved effective antiviral drug. Flux balance analysis (FBA) is an efficient method to analyze metabolic networks ... [more ▼]

The 2019 coronavirus disease (COVID-19) became a worldwide pandemic with currently no approved effective antiviral drug. Flux balance analysis (FBA) is an efficient method to analyze metabolic networks. Here, FBA was applied on human lung cells infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to reposition metabolic drugs and drug combinations against the virus replication within the host tissue. Making use of expression datasets of infected lung tissue, genome-scale COVID-19-specific metabolic models were reconstructed. Then, host-specific essential genes and gene pairs were determined through in silico knockouts that permit reducing the viral biomass production without affecting the host biomass. Key pathways that are associated with COVID-19 severity in lung tissue are related to oxidative stress, ferroptosis, and pyrimidine metabolism. By in silico screening of Food and Drug Administration (FDA)-approved drugs on the putative disease-specific essential genes and gene pairs, 85 drugs and 52 drug combinations were predicted as promising candidates for COVID-19 (https://github.com/sysbiolux/DCcov). [less ▲]

Detailed reference viewed: 39 (0 UL)
See detailEveryday Matters : Contemporary Approaches to Architecture
Grossman, Vanessa; Ciro, Miguel; Miessen, Markus UL

Book published by Ruby Press (2021)

Many architects are seeking ways to respond to a world that suffers from overbuilding, yet where millions remain homeless and lack rudimentary infrastructure. Beyond the built form, these practitioners ... [more ▼]

Many architects are seeking ways to respond to a world that suffers from overbuilding, yet where millions remain homeless and lack rudimentary infrastructure. Beyond the built form, these practitioners are expanding their focus to quotidian objects, basic resources, issues of race and gender, daily routines, and maintenance protocols. Featuring contributions by architectural designers, historians, and theoreticians, as well as scholars in fields such as cultural geography, environmental anthropology, political philosophy, and sociology, this book chronicles how the everyday has influenced contemporary approaches to architecture and urbanism, triggering the rise of a new ethics and aesthetics. [less ▲]

Full Text
Peer Reviewed
See detailAstrocyte-Neuron Metabolic Crosstalk in Neurodegeneration: A Mitochondrial Perspective.
Mulica, Patrycja UL; Grünewald, Anne UL; Pereira, Sandro L.

in Frontiers in endocrinology (2021), 12

Converging evidence made clear that declining brain energetics contribute to aging and are implicated in the initiation and progression of neurodegenerative disorders such as Alzheimer's and Parkinson's ... [more ▼]

Converging evidence made clear that declining brain energetics contribute to aging and are implicated in the initiation and progression of neurodegenerative disorders such as Alzheimer's and Parkinson's disease. Indeed, both pathologies involve instances of hypometabolism of glucose and oxygen in the brain causing mitochondrial dysfunction, energetic failure and oxidative stress. Importantly, recent evidence suggests that astrocytes, which play a key role in supporting neuronal function and metabolism, might contribute to the development of neurodegenerative diseases. Therefore, exploring how the neuro-supportive role of astrocytes may be impaired in the context of these disorders has great therapeutic potential. In the following, we will discuss some of the so far identified features underlining the astrocyte-neuron metabolic crosstalk. Thereby, special focus will be given to the role of mitochondria. Furthermore, we will report on recent advancements concerning iPSC-derived models used to unravel the metabolic contribution of astrocytes to neuronal demise. Finally, we discuss how mitochondrial dysfunction in astrocytes could contribute to inflammatory signaling in neurodegenerative diseases. [less ▲]

Detailed reference viewed: 47 (2 UL)
Full Text
Peer Reviewed
See detailInteroceptive Approaches to Embodiment Research
Schulz, André UL; Vögele, Claus UL

in Robinson, Michael D.; Thomas, Laura E. (Eds.) Handbook of Embodied Psychology: Thinking, Feeling, and Acting. (2021)

Interoception refers to the processing and perception of signals arising from inside the body. Currently, there are two alternative conceptualizations of interoception: (1) an ‘inclusive’ view considering ... [more ▼]

Interoception refers to the processing and perception of signals arising from inside the body. Currently, there are two alternative conceptualizations of interoception: (1) an ‘inclusive’ view considering all bodily signals from inside the body as relevant for interoception, and (2) an ‘exclusive’ view, which is based on receptor types and neurophysiology, and, therefore, a focus on visceroception. These conceptualizations have different implications for the underlying neurophysiology and, therefore, the mechanisms behind embodiment. Thereafter, we discuss current models of interoception and provide definitions of the most common interoceptive terms, which include interoceptive accuracy, sensibility, sensitivity, awareness, and prediction error. We then present examples of interoceptive paradigms to assess different elements of interoception models. Typical interoceptive indicators include self-reports, behavioral measures, and neurophysiological indices. Finally, we discuss the link between interoceptive indicators and emotional experience and emotion regulation, consciousness, and decision-making. These findings illustrate the relevance of interoceptive indicators for embodiment. [less ▲]

Detailed reference viewed: 58 (1 UL)
Full Text
See detailL'indomptable vitalité de la mode
Roelens, Nathalie UL

in forum (2021)

Detailed reference viewed: 46 (2 UL)