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See detailUniversal Hall conductance scaling in non-Hermitian Chern insulators
Groenendijk, Solofo; Schmidt, Thomas UL; Meng, Tobias

in Physical Review Research (2021)

We investigate the Hall conductance of a two-dimensional Chern insulator coupled to an environment causing gain and loss. Introducing a biorthogonal linear response theory, we show that sufficiently ... [more ▼]

We investigate the Hall conductance of a two-dimensional Chern insulator coupled to an environment causing gain and loss. Introducing a biorthogonal linear response theory, we show that sufficiently strong gain and loss lead to a characteristic nonanalytical contribution to the Hall conductance. Near its onset, this contribution exhibits a universal power law with a power 3/2 as a function of Dirac mass, chemical potential, and gain strength. Our results pave the way for the study of non-Hermitian topology in fermionic transport experiments. [less ▲]

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See detailGP2: The Global Parkinson's Genetics Program
Krüger, Rejko UL; The Global Parkinson's Genetics Program, ; The Global Parkinson's Genetics Program,

in Movement Disorders (2021), 36(4), 842-851

To facilitate the rapid expansion of our understanding of the genetic architecture of PD, both in terms of the depth and global context of this knowledge, we have created the Global Parkinson's Genetics ... [more ▼]

To facilitate the rapid expansion of our understanding of the genetic architecture of PD, both in terms of the depth and global context of this knowledge, we have created the Global Parkinson's Genetics Program (GP2; www.gp2.org). GP2 is the first supported resource project of the Aligning Science Across Parkinson's (ASAP) initiative, an audacious effort supporting PD research.9 GP2 is geared toward creating a worldwide collaborative effort that will first dramatically accelerate the identification of genetic contributors to disease and second establish a network of researchers who can best leverage this understanding to research, diagnose, and treat PD worldwide. Here we describe our mission, the path we have proposed to achieve this, and the core principles of data democratization, transparency, and diversity. [less ▲]

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See detailLA KORA A LA CONFLUENCE DES CULTURES : UNE ETUDE DE LA TRANSMISSION D’UN OBJET CULTUREL DANS UN CONTEXTE TRANSCULTUREL CONTEMPORAIN
Ayegnon, Armel Benvide Osée UL

Doctoral thesis (2021)

The kora is a musical instrument of West African origin. Now played by several individuals who do not necessarily come from her native background, it has been transmitted from her endogenous cultural ... [more ▼]

The kora is a musical instrument of West African origin. Now played by several individuals who do not necessarily come from her native background, it has been transmitted from her endogenous cultural circle to other exogenous circles. We ourselves are kora players and belong to this exogenous circle. In our artistic journey and in our personal history, we have felt the need to produce a hybrid game. Thus, as an artist and researcher, our first objective of a doctoral thesis was to research hybridization processes from a so-called "traditional" repertoire and another called "modern". . Our academic career made us question these categorical qualifiers: "traditional", "modern". This questioning took place through the observation of the process of transmission of the kora. It was made from the very history of the instrument which cannot be dissociated from the history of the individuals and communities who adopted it. However, given the great diversity of the stories, it was necessary to think about setting up tools for collecting knowledge related to contexts and material and immaterial objects, relating to the kora. In order to achieve the primary goal we were pursuing, we finally directed this research towards proposing a method of approach to the study of transmission. There is therefore a dialectic between the object approached and the approach used in this research work. It is this dialectic that corresponds to the main objective of this work. Thus, this doctoral thesis aims to answer the following question: "How to think about the transmission of the kora" object-witness "of the meeting of cultures? "It is a double research focusing both on the transmission of the kora and on the means to study and realize this transmission. This research subsequently led to an applied anthropology and even cultural engineering project. This present writing is the summary of an academic adventure between practice and theory. [less ▲]

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See detailETHICAL PERSPECTIVES ON BIG DATA IN AGRI-FOOD: OWNERSHIP AND GOVERNANCE FOR SAFETY
Sapienza, Salvatore UL

Doctoral thesis (2021)

Big data are reshaping the way we interact with technology, thus fostering new applications to increase the safety-assessment of foods, a critical goal in the protec- tion of individuals’ right to health ... [more ▼]

Big data are reshaping the way we interact with technology, thus fostering new applications to increase the safety-assessment of foods, a critical goal in the protec- tion of individuals’ right to health and the flourishing of the food and feed market. An extraordinary amount of information, including real-time data available from multiple sources, is analysed using machine learning approaches aimed at detecting the existence or predicting the likelihood of future risks, thus reducing the inaccu- racy of risk assessment. Food business operators have to share the results of these analyses when applying to place on the market certain products, whereas agri-food safety agencies (including the European Food Safety Authority) are exploring new avenues to increase the accuracy of their evaluations by processing Big data. Such an informational endowment brings with it opportunities and risks correlated to the extraction of meaningful inferences from data. However, conflicting interests and tensions among the involved entities - the industry, food safety agencies, and con- sumers - hinder the finding of shared methods to steer the processing of Big data in a sound, transparent and trustworthy way. Taken together, a recent reform in the EU sectoral legislation, the lack of trust in the EU food safety system proved by the recent Fitness Check of the General Food Law Regulation and the presence of a considerable number of stakeholders highlight the need of ethical contributions aimed at steering the development and the deployment of Big data applications. At the same time, general Artificial Intelligence guidelines and charters published by European Union institutions and Member States have to be discussed in light of applied contexts, including the one at stake. This thesis aims to contribute to these goals by discussing what principles should be put forward when processing Big data in the context of agri-food safety-risk assessment. The research focuses on two narrow and interviewed topics - data ownership and data governance - by evaluating how the regulatory framework addresses the challenges raised by Big data analysis in these domains. To do so, it adopts a cross-disciplinary research methodology that keeps into account both the technological advances and the policy tools adopted in the European Union, while assuming an ethical perspective when exploring poten- tial solutions. The outcome of the project is a tentative Roadmap aimed to identify the principles to be observed when processing Big data in this domain and their possible implementations. [less ▲]

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See detailModern Slavery and Organizational Research: Digital Technologies as Field Configuring Events
Fletcher, Denise Elaine UL

Presentation (2021, March 26)

In this talk, I give an overview of how the topic of modern slavery is represented in the organization and management literature and I outline a research study which focuses on how entrepreneurial ... [more ▼]

In this talk, I give an overview of how the topic of modern slavery is represented in the organization and management literature and I outline a research study which focuses on how entrepreneurial technological solutions are increasingly being developed to address problems of modern slavery and unfree labour [less ▲]

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See detailReconfigurable Intelligent Surface Optimal Placement in Millimeter-Wave Networks
Ntontin, Konstantinos UL; Boulogeorgos, Alexandros-Apostolos A.; Selimis, Dimitrios et al

in IEEE Open Journal of the Communications Society (2021), 2

This work discusses the optimal reconfigurable intelligent surface placement in highly-directional millimeter wave links. In particular, we present a novel system model that takes into account the ... [more ▼]

This work discusses the optimal reconfigurable intelligent surface placement in highly-directional millimeter wave links. In particular, we present a novel system model that takes into account the relationship between the transmission beam footprint at the RIS plane and the RIS size. Subsequently, based on the model we derive the end-to-end expression of the received signal power and, furthermore, provide approximate closed-form expressions in the case that the RIS size is either much smaller or at least equal to the transmission beam footprint. Moreover, building upon the expressions, we derive the optimal RIS placement that maximizes the end-to-end signal-to-noise ratio. Finally, we substantiate the analytical findings by means of simulations, which reveal important trends regarding the optimal RIS placement according to the system parameters. [less ▲]

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See detailWhat Blanchard gets wrong: The puzzling persistence of managerialism in EU fiscal governance
Dani, Marco; Guarascio, Dario; Mendes, Joana UL et al

Diverse speeches and writings (2021)

The Covid-19 pandemic has prompted renewed debate over the architecture of Europe’s Economic and Monetary Union. In a recent blog post, "What Blanchard gets wrong: The puzzling persistence of ... [more ▼]

The Covid-19 pandemic has prompted renewed debate over the architecture of Europe’s Economic and Monetary Union. In a recent blog post, "What Blanchard gets wrong: The puzzling persistence of managerialism in EU fiscal governance", Marco Dani, Dario Guarascio, Joana Mendes, Agustin José Menéndez, Harm Schepel and Mike Wilkinson respond to a recent proposal to overhaul the EU’s current fiscal framework. They argue that while the EU’s fiscal rules should undoubtedly be reformed, a more radical solution is required that puts democratic politics at the heart of the EU’s fiscal governance. [less ▲]

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See detailWealth inequality in the long run
Alfani, Guido; Schifano, Sonia UL

in How Was Life? Volume II: New Perspectives on Well-being and Global Inequality since 1820 (2021)

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See detailPanorama de droit de la consommation 2020
Poillot, Elise UL; Aubry, Hélène; Sauphanor, Natacha

in Recueil Dalloz (2021)

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See detailEmbedding Intelligence in Materials for Responsive Built Environment using Liquid Crystal Elastomer Actuators and Sensors
Schwartz, Mathew; Lagerwall, Jan UL

E-print/Working paper (2021)

Liquid Crystal Elastomers (LCEs) are an exciting category of material that has tremendous application potential across a variety of fields, owing to their unique properties that enable both sensing and ... [more ▼]

Liquid Crystal Elastomers (LCEs) are an exciting category of material that has tremendous application potential across a variety of fields, owing to their unique properties that enable both sensing and actuation. To some, LCEs are simply another type of Shape Memory Polymer, while to others they are an interesting on-going scientific experiment. In this visionary article, we bring an interdisciplinary discussion around creative and impactful ways that LCEs can be applied in the Built Environment to support kinematic and kinetic buildings and situational awareness. We focus particularly on the autonomy made possible by using LCEs, potentially removing needs for motors, wiring and tubing, and even enabling fully independent operation in response to natural environment variations, requiring no power sources. To illustrate the potential, we propose a number of concrete application scenarios where LCEs could offer innovative solutions to problems of great societal importance, such as autonomous active ventilation, heliotropic solar panels systems which can also remove snow or sand autonomously, and invisible coatings with strain mapping functionality, alerting residents in case of dangerous (static or dynamic) loads on roofs or windows, as well as assisting building safety inspection teams after earthquakes. [less ▲]

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See detailPeripheral decarboxylase inhibitors paradoxically induce aromatic L-amino acid decarboxylase
Krüger, Rejko UL; Pavelka, Lukas UL; Mollenhauer, Brit et al

in NPJ Parkinson's Disease (2021)

Peripheral decarboxylase inhibitors (PDIs) prevent the conversion of levodopa to dopamine in the blood by the enzyme aromatic L-amino acid decarboxylase (AADC). Alterations in enzyme activity may ... [more ▼]

Peripheral decarboxylase inhibitors (PDIs) prevent the conversion of levodopa to dopamine in the blood by the enzyme aromatic L-amino acid decarboxylase (AADC). Alterations in enzyme activity may contribute to the required higher dosages of levodopa observed in many patients with Parkinson’s disease. We evaluated the effect of levodopa/PDI use on serum AADC enzyme activity. Serum AADC enzyme activity was evaluated in three independent cohorts of patients with Parkinson’s disease or parkinsonism (n = 301) and compared between patients on levodopa/PDI vs. patients not on this medication. AADC enzyme activity was elevated in 62% of patients on levodopa/PDI treatment, compared to 19% of patients not on levodopa/PDI (median 90 mU/L vs. 50 mU/L, p < 0.001). Patients with elevated AADC activity had longer disease duration and higher doses of levodopa/PDI. These findings may implicate that peripheral AADC induction could underlie a waning effect of levodopa, necessitating dose increases to maintain a sustained therapeutic effect. [less ▲]

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See detailInvesting in Crises
Penasse, Julien UL

Presentation (2021, March 18)

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See detailAus dem Arbeitsalltag einer Sozialforscherin: Unterwegs mit „Chercheurs à l’école“
Höpner, Moritz UL

E-print/Working paper (2021)

In mid-March, our team member Caroline Residori visited a senior class of the Lycée Technique in Lallange. As part of the Chercheurs à l’école initiative, she told the young people between the ages of 17 ... [more ▼]

In mid-March, our team member Caroline Residori visited a senior class of the Lycée Technique in Lallange. As part of the Chercheurs à l’école initiative, she told the young people between the ages of 17 and 21 many new things about the everyday work of a social researcher. Just like her colleague Céline Dujardin, who visited the Athénée de Luxembourg, she created an interesting orientation afternoon as part of this FNR projects. “The everyday life of researchers is much more than hours of reading and concentrated pipetting in the lab,” Caroline emphasizes. “In every research discipline, it pays off to have a closer look,” Céline adds. [less ▲]

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See detailMulticasting Precoder Design for Vehicular Joint Radar-Communication Systems
Dokhanchi, Sayed Hossein UL; Mysore Rama Rao, Bhavani Shankar UL; Kobayashi, Mari et al

in 2021 1st IEEE International Online Symposium on Joint Communications & Sensing (JC&S) (2021, March 16)

We consider the problem of multicasting a single data stream to multiple vehicles in a vehicular network from a joint radar and communication (JRC) equipped vehicle that simultaneously aims to detect ... [more ▼]

We consider the problem of multicasting a single data stream to multiple vehicles in a vehicular network from a joint radar and communication (JRC) equipped vehicle that simultaneously aims to detect multiple targets and estimate their localization parameters such as ranges, Doppler shifts and angles. Assuming channel state information (CSI) is known at the JRC car, we design a precoder that exploits to maximize multicasting rate while simultaneously maximizing the radar Signal to Clutter plus Noise Ratio (SCNR) at the JRC vehicle. [less ▲]

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See detailDeep sequencing of sncRNAs reveals hallmarks and regulatory modules of the transcriptome during Parkinson’s disease progression
Krüger, Rejko UL; Kern, Fabian; Fehlmann, Tobias et al

in Nature Aging (2021)

Noncoding RNAs have diagnostic and prognostic importance in Parkinson’s disease (PD). We studied circulating small non coding RNAs (sncRNAs) in two large-scale longitudinal PD cohorts (Parkinson’s ... [more ▼]

Noncoding RNAs have diagnostic and prognostic importance in Parkinson’s disease (PD). We studied circulating small non coding RNAs (sncRNAs) in two large-scale longitudinal PD cohorts (Parkinson’s Progression Markers Initiative (PPMI) and Luxembourg Parkinson’s Study (NCER-PD)) and modeled their impact on the transcriptome. Sequencing of sncRNAs in 5,450 blood samples of 1,614 individuals in PPMI yielded 323 billion reads, most of which mapped to microRNAs but covered also other RNA classes such as piwi-interacting RNAs, ribosomal RNAs and small nucleolar RNAs. Dysregulated microRNAs associated with disease and disease progression occur in two distinct waves in the third and seventh decade of life. Originating predominantly from immune cells, they resemble a systemic inflammation response and mitochondrial dysfunction, two hall marks of PD. Profiling 1,553 samples from 1,024 individuals in the NCER-PD cohort validated biomarkers and main findings by an independent technology. Finally, network analysis of sncRNA and transcriptome sequencing from PPMI identified regulatory modules emerging in patients with progressing PD [less ▲]

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See detailBlockchain matters – on the phenomenon of legal disembodiment in blockchain technology
Becker, Katrin UL

Scientific Conference (2021, March 15)

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See detailNegative mood increases desire to eat, but not event-related potentials, for food images in bulimia nervosa
Lutz, Annika UL; Georgii, Claudio; Blechert, Jens et al

Scientific Conference (2021, March 12)

Detailed reference viewed: 30 (2 UL)