Histoire de la Justice au Luxembourg (1795 à nos jours). Institutions - Organisation - Acteurs

Book published by De Gruyter (2022)

Privacy-preserving Copy Number Variation Analysis with Homomorphic Encryption

Scientific Conference (2022)

Innovative pharma-genomics and personalized medicine services are now possible thanks to the availability for processing and analysis of a large amount of genomic data. Operating on such databases, is ... [more ▼]

Innovative pharma-genomics and personalized medicine services are now possible thanks to the availability for processing and analysis of a large amount of genomic data. Operating on such databases, is possible to test for predisposition to diseases by searching for genomic variants on whole genomes as well as on exomes, which are collections of protein coding regions called exons. Genomic data are therefore shared amongst research institutes, public/private operators, and third parties, creating issues of privacy, ethics, and data protection because genome data are strictly personal and identifying. To prevent damages that could follow a data breach—a likely threat nowadays—and to be compliant with current data protection regulations, genomic data files should be encrypted, and the data processing algorithms should be privacy-preserving. Such a migration is not always feasible: not all operations can be implemented straightforwardly to be privacypreserving; a privacy-preserving version of an algorithm may not be as accurate for the purpose of biomedical analysis as the original; or the privacy-preserving version may not scale up when applied to genomic data processing because of inefficiency in computation time. In this work, we demonstrate that at least for a wellknown genomic data procedure for the analysis of copy number variants called copy number variations (CNV) a privacy-preserving analysis is possible and feasible. Our algorithm relies on Homomorphic Encryption, a cryptographic technique to perform calculations directly on the encrypted data. We test our implementation for performance and reliability, giving evidence that it is practical to study copy number variations and preserve genomic data privacy. Our proof-of-concept application successfully and efficiently searches for a patient’s somatic copy number variation changes by comparing the patient gene coverage in the whole exome with a healthy control exome coverage. Since all the genomics data are securely encrypted, the data remain protected even if they are transmitted or shared via an insecure environment like a public cloud. Being this the first study for privacy-preserving copy number variation analysis, we demonstrate the potential of recent Homomorphic Encryption tools in genomic applications. [less ▲]

On the sociopolitical and institutional production of digital cities

Presentation (2022)

Corporate social responsibility budgeting and spending during COVID–19 in Oman: A humanitarian response to the pandemic

in Finance Research Letters (2022)

COVID–19 is causing economic panic among people, governments, and businesses, requiring greater corporate social responsibility (CSR). Using a sample of Omani-listed firms, this study shows that CSR ... [more ▼]

COVID–19 is causing economic panic among people, governments, and businesses, requiring greater corporate social responsibility (CSR). Using a sample of Omani-listed firms, this study shows that CSR budgeting and spending have increased considerably during the pandemic. It also shows that CSR budgeting is positively affected by the increase in COVID–19 deaths. CSR spending increases with the number of COVID–19 confirmed and fatal cases. These findings suggest that firms resort to CSR to reduce the negative consequences of the pandemic. [less ▲]

On Leopoldt's and Gross's defects for Artin representations

E-print/Working paper (2022)

We generalize Waldschmidt's bound for Leopoldt's defect and prove a similar bound for Gross's defect for an arbitrary extension of number fields. As an application, we prove new cases of the generalized ... [more ▼]

We generalize Waldschmidt's bound for Leopoldt's defect and prove a similar bound for Gross's defect for an arbitrary extension of number fields. As an application, we prove new cases of the generalized Gross conjecture (also known as the Gross-Kuz'min conjecture) beyond the classical abelian case, and we show that Gross's p-adic regulator has at least half of the conjectured rank. We also describe and compute non-cyclotomic analogues of Gross's defect. [less ▲]

Quelques remarques sur la notion de sécurité juridique dans la tradition de Common Law

in Cerqueira, Gustavo; Fulchiron, Hugues; Nord, Nicholas (Eds.) “Insécurité Juridique” – L’émergence d’une notion ? (2022)

DLT-Based Enhancement of Cross-Border Payment Efficiency – a Legal and Regulatory Perspective

E-print/Working paper (2022)

Is Eve nearby? Analysing protocols under the distant-attacker assumption

in IEEE Computer Security Foundations Symposium, August 7 - 10, 2022, Haifa, Israel (2022)

From gravity to string topology

E-print/Working paper (2022)

The chain gravity properad introduced earlier by the author acts on the cyclic Hochschild of any cyclic A∞ algebra equipped with a scalar product of degree −d. In particular, it acts on the cyclic ... [more ▼]

The chain gravity properad introduced earlier by the author acts on the cyclic Hochschild of any cyclic A∞ algebra equipped with a scalar product of degree −d. In particular, it acts on the cyclic Hochschild complex of any Poincare duality algebra of degree d, and that action factors through a quotient dg properad ST3−d of ribbon graphs which is in focus of this paper. We show that its cohomology properad H∙(ST3−d) is highly non-trivial and that it acts canonically on the reduced equivariant homology H¯S1∙(LM) of the loop space LM of any simply connected d-dimensional closed manifold M. By its very construction, the string topology properad H∙(ST3−d) comes equipped with a morphism from the gravity properad which is fully determined by the compactly supported cohomology of the moduli spaces Mg,n of stable algebraic curves of genus g with marked points. This result gives rise to new universal operations in string topology as well as reproduces in a unified way several known constructions: we show that (i) H∙(ST3−d) is also a properad under the properad of involutive Lie bialgebras in degree 3−d whose induced action on H¯S1∙(LM) agrees precisely with the famous purely geometric construction of M. Chas and D. Sullivan, (ii) H∙(ST3−d) is a properad under the properad of homotopy involutive Lie bialgebras in degree 2−d; (iii) E. Getzler's gravity operad injects into H∙(ST3−d) implying a purely algebraic counterpart of the geometric construction of C. Westerland establishing an action of the gravity operad on H¯S1∙(LM). [less ▲]

Die Grenzen aufgezeigt:Technische Innovation und räumliche Abstraktion am Beispiel früher Landkarten der Grenzregion zwischen dem Herzogtum Luxemburg und dem Kurfürstentum Trier

in Schröder, Lina; Wegewitz, Markus (Eds.) Europäische Grenzregionen. Neue Wege im Umgang mit historischen Raum- und Grenzkonzeptionen in der Geschichtswissenschaft (2022)

Die Ausbildung und Verfestigung der kurtrierischen und luxemburgischen Landesherrschaften war im 14. Jahrhundert weitgehend zum Abschluss gekommen. Die Transformation vom Personenverbands- zum ... [more ▼]

Die Ausbildung und Verfestigung der kurtrierischen und luxemburgischen Landesherrschaften war im 14. Jahrhundert weitgehend zum Abschluss gekommen. Die Transformation vom Personenverbands- zum Flächenstaat frühneuzeitlicher Prägung hatte die Ausbildung einer zunehmend deutlicheren Grenze zwischen beiden Territorien zur Folge. Ebenso formierte sich auch eine Grenze im Grenzraum mit Frankreich und Lothringen. Die vereinfachende Darstellung komplexer teils überlagerter Grenzzonen in Form von abstrahierenden Linien musste von den zeitgenössischen Kartographen jedoch erst noch entwickelt werden. Die älteste regionale Karte mit einer angedeuteten partiellen Grenzmarkierung stammt aus dem Jahr 1555. Eine zunehmende Professionalisierung der Kartographie gelang ab der zweiten Hälfte des 16. Jahrhunderts durch Landesaufnahmen, initiiert von den jeweiligen Landesherren. Die Intention der Auftraggeber war dabei ähnlich: einerseits sollte das jeweilige Territorium durch die Karte möglichst als geschlossen beherrschter Raum dargestellt werden, andererseits galt es, die bisher nur verbal beschriebenen teils strittigen Grenzen als abstrakte Linien deutlich sichtbar zu machen. Die Karten der Landesaufnahmen waren zunächst geheim, dennoch fanden sie bereits nach wenigen Jahren Eingang in die Atlanten von Ortelius, de Jode und Mercator. Diese beeinflussten wiederum die Karten der Region in den späteren Atlanten der niederländischen, französischen und süddeutschen Kartenverleger. Der Beitrag beschreibt, ab wann und in welcher Form Grenzen in frühen Karten (16.-18. Jahrhundert) dargestellt wurden. Besonders in den Blick genommen wird der Prozess der Ausbildung von Linien zur abstrakten Darstellung unklarer, teils strittiger Grenzräume sowie die zunehmende Professionalisierung und Genauigkeit in der kartographischen Darstellung durch Vermessungen im Feld. [less ▲]