DING, BINGG, Dings. Kaffee, Soundwords und Bewegungsspuren in Max Baitingers Comic "Röhner".

in Börnchen, Stefan; Liebrand, Claudia (Eds.) Lauschen und Überhören. Literarische und mediale Aspekte auditiver Offenheit. (2016)

Named entity recognition applied on a data base of Medieval Latin charters. The case of chartae burgundiae

in 3rd International Workshop on Computational History (HistoInformatics 2016) (2016)

Chromatin-Bound MDM2 Regulates Serine Metabolism and Redox Homeostasis Independently of p53.

in Molecular cell (2016), 62(6), 890-902

The mouse double minute 2 (MDM2) oncoprotein is recognized as a major negative regulator of the p53 tumor suppressor, but growing evidence indicates that its oncogenic activities extend beyond p53. Here ... [more ▼]

The mouse double minute 2 (MDM2) oncoprotein is recognized as a major negative regulator of the p53 tumor suppressor, but growing evidence indicates that its oncogenic activities extend beyond p53. Here, we show that MDM2 is recruited to chromatin independently of p53 to regulate a transcriptional program implicated in amino acid metabolism and redox homeostasis. Identification of MDM2 target genes at the whole-genome level highlights an important role for ATF3/4 transcription factors in tethering MDM2 to chromatin. MDM2 recruitment to chromatin is a tightly regulated process that occurs during oxidative stress and serine/glycine deprivation and is modulated by the pyruvate kinase M2 (PKM2) metabolic enzyme. Depletion of endogenous MDM2 in p53-deficient cells impairs serine/glycine metabolism, the NAD(+)/NADH ratio, and glutathione (GSH) recycling, impacting their redox state and tumorigenic potential. Collectively, our data illustrate a previously unsuspected function of chromatin-bound MDM2 in cancer cell metabolism. [less ▲]

Suivre « le char d’une femme célèbre » : Benjamin Constant et Germaine de Staël face à la question du genre

in Loxias (2016), XIII

S’appuyant sur les Journaux intimes de Benjamin Constant et la littérature critique à leur propos, le présent article se penche sur la façon dont cet adepte de l’introspection perçoit les conventions ... [more ▼]

S’appuyant sur les Journaux intimes de Benjamin Constant et la littérature critique à leur propos, le présent article se penche sur la façon dont cet adepte de l’introspection perçoit les conventions genrées de son temps et, à l’aune de cette norme, la lecture qu’il fait de son propre rôle dans sa relation avec Germaine de Staël, relation qu’il n’hésite pas à qualifier d’exceptionnelle. Le propos se centre sur la façon dont l’écrivain exprime cette perception dans l’intimité absolue de ses Journaux intimes, lieu privilégié d’une quête identitaire et d’une construction de soi qui culminent dans Amélie et Germaine, son premier journal, où Constant procède à une auto-analyse à la lumière de ses rapports avec les deux femmes. L’article cherche à montrer comment Constant, déchiré entre un désir d’émancipation qui est aussi une aspiration à la gloire et une peur du changement qui le paralyse, tente, dans cet espace de l’intime, de définir son identité et d’agir sur son être profond, afin de pouvoir envisager l’avenir. [less ▲]

Developing a web-based system to visualize vegetation trends by a nonlinear regression algorithm

Bachelor/master dissertation (2016)

Comparing with traditional linear regression methods that used to monitor vegetation trends, a nonlinear regression algorithm (PolyTrend) developed by Jamali et al. (2014) can provide more accurate ... [more ▼]

Comparing with traditional linear regression methods that used to monitor vegetation trends, a nonlinear regression algorithm (PolyTrend) developed by Jamali et al. (2014) can provide more accurate information of vegetation trends by fitting a polynomial line with a degree of up to three for ASCII-formed time-series NDVI (Normalized Difference Vegetation Index) dataset of a single pixel. To extend the ability of the PolyTrend algorithm for processing time-series NDVI satellite imagery and to increase its accessibility, a web-based system for visualizing vegetation trends by the PolyTrend algorithm has been developed. The PolyTrend web-based system allows users to define the value of statistical significance of the PolyTrend algorithm, the nominal range of the input data, and the range of desired NDVI input to be processed. It applies the PolyTrend algorithm to each pixel of the uploaded time-series NDVI satellite imagery dataset. It returns the types of vegetation changes, the slope of the changes of NDVI values in the whole time span, and whether the net change of NDVI increases or decreases during this period, in the forms of ASCII files (i.e. text files) and binary files (i.e. images). By refining the existing PolyTrend algorithm written in MATLAB and embedding it in a web environment, the PolyTrend web-based system has proved its ability in monitoring global vegetation trends using raw time-series NDVI satellite imagery. [less ▲]

Música conceptual, catalizadora del giro hacia la estética del contenido inmaterial

in Sul Ponticello (2016), 32(104),

miR-322 regulates insulin signaling pathway and protects against metabolic syndrome-induced cardiac dysfunction in mice.

in Biochimica et biophysica acta (2016), 1862(4), 611-621

We identified murine miR-322, orthologous to human miR-424, as a new regulator of insulin receptor, IGF-1 receptor and sirtuin 4 mRNA in vitro and in vivo in the heart and found that miR-322/424 is highly ... [more ▼]

We identified murine miR-322, orthologous to human miR-424, as a new regulator of insulin receptor, IGF-1 receptor and sirtuin 4 mRNA in vitro and in vivo in the heart and found that miR-322/424 is highly expressed in the heart of mice. C57Bl/6N mice fed 10weeks of high fat diet (HFD) presented signs of cardiomyopathy and a stable miR-322 cardiac level while cardiac function was slightly affected in 11week-old ob/ob which overexpressed miR-322. We thus hypothesized that mmu-miR-322 could be protective against cardiac consequences of hyperinsulinemia and hyperlipidemia. We overexpressed or knocked-down mmu-miR-322 using AAV9 and monitored cardiac function in wild-type C57Bl/6N mice fed a control diet (CD) or a HFD and in ob/ob mice. The fractional shortening progressively declined while the left ventricle systolic diameter increased in HFD mice infected with an AAVcontrol or with an AAVsponge (decreasing miR-322 bioavailability) but also in ob/ob mice infected with AAVsponge. Similar observations were also found in CD-fed mice infected with AAVsponge. On the contrary over-expressing miR-322 with AAVmiR-322 was efficient in protecting the heart from HFD effects in C57Bl/6N mice. This cardioprotection could be associated with the regulation of identified targets IGF1R, INSR and CD1, a decrease in insulin signaling pathway and an enrichment of genes involved in mitochondrial function and fatty acid oxidation as demonstrated by transcriptome analysis. Altogether, these results emphasize miR-322 as a new potential therapeutic target against cardiac consequences of metabolic syndrome, which represents an increasing burden in the western countries. [less ▲]

Role of lipid phosphate phosphatase 3 in human aortic endothelial cell function.

in Cardiovascular research (2016), 112(3), 702-713

AIMS: Lipid phosphate phosphatase 3; type 2 phosphatidic acid phosphatase β (LPP3; PPAP2B) is a transmembrane protein dephosphorylating and thereby terminating signalling of lipid substrates including ... [more ▼]

AIMS: Lipid phosphate phosphatase 3; type 2 phosphatidic acid phosphatase β (LPP3; PPAP2B) is a transmembrane protein dephosphorylating and thereby terminating signalling of lipid substrates including lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P). Human LPP3 possesses a cell adhesion motif that allows interaction with integrins. A polymorphism (rs17114036) in PPAP2B is associated with coronary artery disease, which prompted us to investigate the possible role of LPP3 in human endothelial dysfunction, a condition promoting atherosclerosis. METHODS AND RESULTS: To study the role of LPP3 in endothelial cells we used human primary aortic endothelial cells (HAECs) in which LPP3 was silenced or overexpressed using either wild type or mutated cDNA constructs. LPP3 silencing in HAECs enhanced secretion of inflammatory cytokines, leucocyte adhesion, cell survival, and migration and impaired angiogenesis, whereas wild-type LPP3 overexpression reversed these effects and induced apoptosis. We also demonstrated that LPP3 expression was negatively correlated with vascular endothelial growth factor expression. Mutations in either the catalytic or the arginine-glycine-aspartate (RGD) domains impaired endothelial cell function and pharmacological inhibition of S1P or LPA restored it. LPA was not secreted in HAECs under silencing or overexpressing LPP3. However, the intra- and extra-cellular levels of S1P tended to be correlated with LPP3 expression, indicating that S1P is probably degraded by LPP3. CONCLUSIONS: We demonstrated that LPP3 is a negative regulator of inflammatory cytokines, leucocyte adhesion, cell survival, and migration in HAECs, suggesting a protective role of LPP3 against endothelial dysfunction in humans. Both the catalytic and the RGD functional domains were involved and S1P, but not LPA, might be the endogenous substrate of LPP3. [less ▲]

Les catholiques anglais face à la conversion. Parcours et représentations au XVIe siècle

in Martin, Ph.; Suire, E. (Eds.) Les Convertis : parcours religieux, parcours politiques, vol. 1 (2016)

Souveraineté territoriale par traité, written by Mamadou Hébié

in Journal of the History of International Law (2016), 18(4), 469-479