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![]() Fernandez de Henestrosa, Martha ![]() ![]() ![]() Report (2020) Detailed reference viewed: 49 (3 UL)![]() Lehmann, Harry ![]() in Lettre International. Europas Kulturzeitung (2020), (131), 56-61 Detailed reference viewed: 19 (2 UL)![]() Menetrey, Séverine ![]() in Pasicrisie Luxembourgeoise: Recueil Trimestriel de la Jurisprudence Luxembourgeoise (2020), t. 39, 4/2020 Detailed reference viewed: 23 (0 UL)![]() Terzidou, Kalliopi ![]() in Journal of the Association for Computing Machinery (2020, December) Detailed reference viewed: 65 (11 UL)![]() ; ; et al in Journal of Immunology (2020), 205(11), 3154-3166 The proliferation, differentiation, and survival of cells of the mononuclear phagocyte system (MPS; progenitors, monocytes, macrophages, and classical dendritic cells) are controlled by signals from the M ... [more ▼] The proliferation, differentiation, and survival of cells of the mononuclear phagocyte system (MPS; progenitors, monocytes, macrophages, and classical dendritic cells) are controlled by signals from the M-CSF receptor (CSF1R). Cells of the MPS lineage have been identified using numerous surface markers and transgenic reporters, but none is both universal and lineage restricted. In this article, we report the development and characterization of a CSF1R reporter mouse. A FusionRed (FRed) cassette was inserted in-frame with the C terminus of CSF1R, separated by a T2A-cleavable linker. The insertion had no effect of CSF1R expression or function. CSF1R-FRed was expressed in monocytes and macrophages and absent from granulocytes and lymphocytes. In bone marrow, CSF1R-FRed was absent in lineage-negative hematopoietic stem cells, arguing against a direct role for CSF1R in myeloid lineage commitment. It was highly expressed in marrow monocytes and common myeloid progenitors but significantly lower in granulocyte-macrophage progenitors. In sections of bone marrow, CSF1R-FRed was also detected in osteoclasts, CD169+ resident macrophages, and, consistent with previous mRNA analysis, in megakaryocytes. In lymphoid tissues, CSF1R-FRed highlighted diverse MPS populations, including classical dendritic cells. Whole mount imaging of nonlymphoid tissues in mice with combined CSF1R-FRed/Csf1r-EGFP confirmed the restriction of CSF1R expression to MPS cells. The two markers highlight the remarkable abundance and regular distribution of tissue MPS cells, including novel macrophage populations within tendon and skeletal muscle and underlying the mesothelial/serosal/capsular surfaces of every major organ. The CSF1R-FRed mouse provides a novel reporter with exquisite specificity for cells of the MPS. [less ▲] Detailed reference viewed: 21 (0 UL)![]() Janz, Nina ![]() Presentation (2020, November 27) Cultural Heritage - Definitions and Approach in Archives and in Academic Research Detailed reference viewed: 110 (3 UL)![]() Damodaran, Aditya Shyam Shankar ![]() ![]() Software (2020) Detailed reference viewed: 24 (3 UL)![]() ; ; et al in Frontiers in Microbiology (2020), 11 Glacier-fed streams (GFSs) exhibit near-freezing temperatures, variable flows, and often high turbidities. Currently, the rapid shrinkage of mountain glaciers is altering the delivery of meltwater ... [more ▼] Glacier-fed streams (GFSs) exhibit near-freezing temperatures, variable flows, and often high turbidities. Currently, the rapid shrinkage of mountain glaciers is altering the delivery of meltwater, solutes, and particulate matter to GFSs, with unknown consequences for their ecology. Benthic biofilms dominate microbial life in GFSs, and play a major role in their biogeochemical cycling. Mineralization is likely an important process for microbes to meet elemental budgets in these systems due to commonly oligotrophic conditions, and extracellular enzymes retained within the biofilm enable the degradation of organic matter and acquisition of carbon (C), nitrogen (N), and phosphorus (P). The measurement and comparison of these extracellular enzyme activities (EEA) can in turn provide insight into microbial elemental acquisition effort relative to environmental availability. To better understand how benthic biofilm communities meet resource demands, and how this might shift as glaciers vanish under climate change, we investigated biofilm EEA in 20 GFSs varying in glacier influence from New Zealand’s Southern Alps. Using turbidity and distance to the glacier snout normalized for glacier size as proxies for glacier influence, we found that bacterial abundance (BA), chlorophyll a (Chl a), extracellular polymeric substances (EPS), and total EEA per gram of sediment increased with decreasing glacier influence. Yet, when normalized by BA, EPS decreased with decreasing glacier influence, Chl a still increased, and there was no relationship with total EEA. Based on EEA ratios, we found that the majority of GFS microbial communities were N-limited, with a few streams of different underlying bedrock geology exhibiting P-limitation. Cell-specific C-acquiring EEA was positively related to the ratio of Chl a to BA, presumably reflecting the utilization of algal exudates. Meanwhile, cell-specific N-acquiring EEA were positively correlated with the concentration of dissolved inorganic nitrogen (DIN), and both N- and P-acquiring EEA increased with greater cell-specific EPS. Overall, our results reveal greater glacier influence to be negatively related to GFS biofilm biomass parameters, and generally associated with greater microbial N demand. These results help to illuminate the ecology of GFS biofilms, along with their biogeochemical response to a shifting habitat template with ongoing climate change. [less ▲] Detailed reference viewed: 64 (0 UL)![]() Ley, Christophe ![]() in Econometrics and Statistics (2020) The normal distribution is well-known for several results that it is the only to fulfil. Much less well-known is the fact that many of these characterizations follow from the fact that the derivative of ... [more ▼] The normal distribution is well-known for several results that it is the only to fulfil. Much less well-known is the fact that many of these characterizations follow from the fact that the derivative of the log-density of the normal distribution is the (negative) identity function. This a priori very simple yet surprising observation allows a deeper understanding of existing characterizations and paves the way for an immediate extension of various seemingly normal-based characterizations to a general density by replacing the (negative) identity function in these results with the derivative of that log-density. [less ▲] Detailed reference viewed: 17 (2 UL)![]() Zizovic, Milena ![]() Bachelor/master dissertation (2020) Epilepsy is affecting people of all age and gender. The disease is traditionally treated with application of antiepileptic drugs. The therapy choice mostly relies on the differential diagnosis which is ... [more ▼] Epilepsy is affecting people of all age and gender. The disease is traditionally treated with application of antiepileptic drugs. The therapy choice mostly relies on the differential diagnosis which is not always easy to be deducted. The treatment guidelines and antiepileptics are diverged according to major epilepsy types – generalized and focal epilepsy. However, prospective studies of antiepileptic drug effectiveness on the European cohort have shown that pharmacoresponse is patient dependent. In this thesis the antiepileptic drug prescription trend in this cohort in generalized and focal epilepsy patients was investigated. Moreover, the use of antiepileptics in the clinics from the EpiPGX database was compared to the findings of their use in general practices in the UK. To explain the difference in patient response to therapy AED-target interactions were investigated on the level of databases. In addition, with the discovery of new genes implicated in epilepsy and success of drugs of other groups such as quinidine and fampridine in treating the symptoms, the drug-repurposing found its application in epilepsy. In this thesis, quinidine-KCNT1 and fampridine-KCNA2 interactions were investigated in order to estimate the feasibility of using public databases to select drug-target interactions for clinical application. The investigation relied mainly on the ChEMBL database. However, these genes were not found among antiepileptic drug targets in the database. Quinidine and fampridine were assay associated with other AED targets. The results suggest that the therapy choice for treatment of rare forms of epilepsy underlined by channelopathies could be significantly expanded, but that database approach requires high level of drug-target selection criteria and text mining. [less ▲] Detailed reference viewed: 92 (5 UL)![]() Cauvin, Thomas ![]() Scientific Conference (2020, November 06) Detailed reference viewed: 21 (1 UL)![]() Cauvin, Thomas ![]() Scientific Conference (2020, November 06) Detailed reference viewed: 19 (1 UL)![]() Cheng, Hao ![]() ![]() ![]() in Liardet, Pierre-Yvan; Mentens, Nele (Eds.) Smart Card Research and Advanced Applications, 19th International Conference, CARDIS 2020, Virtual Event, November 18–19, 2020, Revised Selected Papers (2020, November) Recent progress in quantum computing has increased interest in the question of how well the existing proposals for post-quantum cryptosystems are suited to replace RSA and ECC. While some aspects of this ... [more ▼] Recent progress in quantum computing has increased interest in the question of how well the existing proposals for post-quantum cryptosystems are suited to replace RSA and ECC. While some aspects of this question have already been researched in detail (e.g. the relative computational cost of pre- and post-quantum algorithms), very little is known about the RAM footprint of the proposals and what execution time they can reach when low memory consumption rather than speed is the main optimization goal. This question is particularly important in the context of the Internet of Things (IoT) since many IoT devices are extremely constrained and possess only a few kB of RAM. We aim to contribute to answering this question by exploring the software design space of the lattice-based key-encapsulation scheme ThreeBears on an 8-bit AVR microcontroller. More concretely, we provide new techniques for the optimization of the ring arithmetic of ThreeBears (which is, in essence, a 3120-bit modular multiplication) to achieve either high speed or low RAM footprint, and we analyze in detail the trade-offs between these two metrics. A low-memory implementation of BabyBear that is secure against Chosen Plaintext Attacks (CPA) needs just about 1.7 kB RAM, which is significantly below the RAM footprint of other lattice-based cryptosystems reported in the literature. Yet, the encapsulation time of this RAM-optimized BabyBear version is below 12.5 million cycles, which is less than the execution time of scalar multiplication on Curve25519. The decapsulation is more than four times faster and takes roughly 3.4 million cycles on an ATmega1284 microcontroller. [less ▲] Detailed reference viewed: 89 (13 UL)![]() Saintes, Laetitia ![]() in Cahiers staëliens (2020), 70 Introduction au dossier "Le Groupe de Coppet et l'écriture polémique" des Cahiers staëliens 70 (2020). Detailed reference viewed: 33 (3 UL)![]() ![]() Calcio, Mathilde ![]() in Méga Code civil 2021-2022, 2e partie (2020) Le Mégacode civil Dalloz offre aux utilisateurs du Code civil un supplément de substance juridique exclusif : dans une zone d’annotations de jurisprudence spécifique, après la jurisprudence du « petit » ... [more ▼] Le Mégacode civil Dalloz offre aux utilisateurs du Code civil un supplément de substance juridique exclusif : dans une zone d’annotations de jurisprudence spécifique, après la jurisprudence du « petit » Code civil, le Mégacode civil explore la jurisprudence largement méconnue résultant des arrêts non publiés de la Cour de cassation et des décisions inédites des juridictions du fond, révélée par l’interrogation systématique des bases de données juridiques. Le Mégacode civil a fait peau neuve. Sur la forme d’abord, il est désormais divisé en 2 parties : la première, comprend les articles 1er à 1099-1 du code civil, c’est-à-dire les généralités sur la loi, les personnes, les biens, et le droit des successions et des libéralités. La 2e partie, de l’article 1100 à la fin du code civil comprend le droit des contrats et des obligations, la preuve, les contrats spéciaux, les régimes matrimoniaux, les sûretés… Sur le fond ensuite, cette édition voit la création d’une nouvelle zone FOCUS, à la suite des annotations spécifiques du mégacode, afin d’explorer de façon très fine certaines points de jurisprudence. Cette édition comprend plusieurs dizaines de milliers de décisions référencées, donnant une vision plus précise et plus pratique de la jurisprudence, mêlant illustrations, chiffrages et descriptions de tendance permettant d’en comprendre l’évolution et d’en faire bon usage. [less ▲] Detailed reference viewed: 10 (0 UL)![]() Garcia Olmedo, Javier ![]() Presentation (2020, November) Detailed reference viewed: 31 (1 UL)![]() Stefan, Oana Adelina ![]() in Luxury: History, Culture, Consumption (2020), 7(1), 69-71 Detailed reference viewed: 24 (9 UL)![]() Dording, Carole ![]() Doctoral thesis (2020) In our project, we investigate the scientific validity of a specific self-built Adaptive Learning Tool in the field of dynamic geometry with a focus on the individual learning pathways of a highly diverse ... [more ▼] In our project, we investigate the scientific validity of a specific self-built Adaptive Learning Tool in the field of dynamic geometry with a focus on the individual learning pathways of a highly diverse student population. A total of 164 children in Luxembourgish elementary schools, aged between 10 and 13 years, acted as the test group and explored elementary geometric concepts in a sequence of learning assignments created with GeoGebra, a dynamic mathematics system which is integrated into the computer-assisted testing framework TAO. They actively built new knowledge in an autonomous way and at their own pace with only minor support interventions by their teacher. Based on easily exploitable data collected within a sequence of exploratory learning assignments, the GEOGEBRATAO tool analyses the answers provided by the child and performs a diagnostic of the child’s competencies in geometry. With respect to this outcome, the tool manages to identify children struggling with geometry concepts and subsequently proposes a differentiated individual pathway through scaffolding and feedback practices. The children can voluntarily watch short video clips aimed to help them better understand any task that they might have difficulty with. A spaced repetition feature is another highly useful component of the tool. Pre- and post-test results show that the test group (working with the GEOGEBRATAO tool) and a parallel working control group (following a traditional paper-and-pencil geometry course), increased their geometry skills and knowledge through the training program, with the test group performing even better in items related to dynamic geometry. In addition, a more precise analysis within clusters based on similar performances in both pre- and post-tests and the child’s progress within the GEOGEBRATAO activities, provides evidence of some common ways of working with our educational technology tool, leading to overall improvement at an individualized level. [less ▲] Detailed reference viewed: 257 (57 UL)![]() Kirsch, Claudine ![]() ![]() Presentation (2020, October 21) Detailed reference viewed: 67 (0 UL)![]() Erpelding, Michel ![]() in Journal of the History of International Law (2020, October 21), 22(2-3), 446-472 Using the example of the European Court of Justice (ECJ), this article addresses the lack of historical contextualization which is prevalent in most general accounts of EU law and EU institutions. It ... [more ▼] Using the example of the European Court of Justice (ECJ), this article addresses the lack of historical contextualization which is prevalent in most general accounts of EU law and EU institutions. It argues that this narrative is the result of a tradition established by the founders of the discipline. For these early ‘Euro-lawyers’, distinguishing the practice of European institutions from earlier international institutions had important political implications. This was especially true with regard to the ECJ. By providing a selective and partly decontextualized narrative of this court and describing it as largely unprecedented in international law, early Euro-lawyers were not only able to bolster the ‘supranational’ and ‘sui generis’ character of their nascent discipline. They were also able to avoid comparisons between the ECJ and prior international courts and tribunals whose similarly wide-ranging powers and integrated nature had been considered as politically problematic. [less ▲] Detailed reference viewed: 61 (1 UL) |
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