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See detailCentralized Gateway Concept for Precoded Multi-beam GEO Satellite Networks
Kisseleff, Steven UL; Lagunas, Eva UL; Krivochiza, Jevgenij et al

in VTC2021-Fall Workshop on Evolution of Non-Terrestrial Networks Toward 6G, Sept. 2021 (2021)

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See detailGendered Prices
Kräussl, Roman UL; Adams, Renee B.; Navone, Marco A. et al

in Review of Financial Studies (2021), 34(8)(3789-3839),

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See detailToward Better Tasks in Sustainability Education: Search for New Approaches on Online Platforms
Andersen, Katja Natalie UL

in Global Journal of Science Frontier Research (2021), 21(5), 1-6

The O-TAPSE study deals with the question to what extent the sustainable development goals (SDGs) formulated by the UN (2015) are addressed in the latest online tasks for primary science education. The ... [more ▼]

The O-TAPSE study deals with the question to what extent the sustainable development goals (SDGs) formulated by the UN (2015) are addressed in the latest online tasks for primary science education. The tasks of three online platforms were evaluated by four primary school teachers with regard to the occurrence of content on the SDGs. The results of the study and their analysis show a clear need for action to further implement these contents in online tasks. [less ▲]

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See detailHilbert Sinkhorn Divergence for Optimal Transport
Li, Qian; Wang, Zhichao; Li, Gang et al

in Proceedings of 2021 IEEE/CVF Conference on Computer Vision and Pattern Recognition - CVPR'21 (2021)

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See detailInklusionssensible Bildungsmaterialien als „Must-have“: Hilfen bei der Bewertung von Vorhandenem und eigenen Erstellung von Neuem
Vogt, Michaela; Andersen, Katja Natalie UL; Bagger, Anette et al

in Grundschule aktuell (2021), 17(155), 18-21

Möchte man im Unterricht den diversen Bedarfslagen aller SchülerInnen gerecht werden, steht man als Lehrperson vor vielseitigen Herausforderungen. Dass hier personelle Ressourcen eine zentrale Rolle ... [more ▼]

Möchte man im Unterricht den diversen Bedarfslagen aller SchülerInnen gerecht werden, steht man als Lehrperson vor vielseitigen Herausforderungen. Dass hier personelle Ressourcen eine zentrale Rolle spielen, wird zwar häufig betont, jedoch kaum schuladministrativ ausreichend berücksichtigt. Um die Lehrpersonen trotzdem handlungsfähig zu halten, müssen deshalb andere Optionen mitgedacht und im Sinne unterstützender Maßnahmen realisiert werden. Hierzu zählen u. a. eine umfängliche Professionalisierung in der LehrerInnenaus- und -weiterbildung wie ebenso Beratungsstrukturen für unterrichtliche Problemlagen. [less ▲]

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See detailRecent analytical methods for risk assessment of emerging contaminants in ecosystems
Bataineh, Mahmoud; Schymanski, Emma UL; Gallampois, Christine M. J.

in Pollution Assessment for Sustainable Practices in Applied Sciences and Engineering (2021)

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See detailDynamic Bandwidth Allocation and Precoding Design for Highly-Loaded Multiuser MISO in Beyond 5G Networks
Vu, Thang Xuan UL; Chatzinotas, Symeon UL; Ottersten, Björn UL

in IEEE Transactions on Wireless Communications (2021)

Multiuser techniques play a central role in the fifth-generation (5G) and beyond 5G (B5G) wireless networks that exploit spatial diversity to serve multiple users simultaneously in the same frequency ... [more ▼]

Multiuser techniques play a central role in the fifth-generation (5G) and beyond 5G (B5G) wireless networks that exploit spatial diversity to serve multiple users simultaneously in the same frequency resource. It is well known that a multi-antenna base station (BS) can efficiently serve a number of users not exceeding the number of antennas at the BS via precoding design. However, when there are more users than the number of antennas at the BS, conventional precoding design methods perform poorly because inter-user interference cannot be efficiently eliminated. In this paper, we investigate the performance of a highly-loaded multiuser system in which a BS simultaneously serves a number of users that is larger than the number of antennas. We propose a dynamic bandwidth allocation and precoding design framework and apply it to two important problems in multiuser systems: i) User fairness maximization and ii) Transmit power minimization, both subject to predefined quality of service (QoS) requirements. The premise of the proposed framework is to dynamically assign orthogonal frequency channels to different user groups and carefully design the precoding vectors within every user group. Since the formulated problems are non-convex, we propose two iterative algorithms based on successive convex approximations (SCA), whose convergence is theoretically guaranteed. Furthermore, we propose a low-complexity user grouping policy based on the singular value decomposition (SVD) to further improve the system performance. Finally, we demonstrate via numerical results that the proposed framework significantly outperforms existing designs in the literature. [less ▲]

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See detailLIPAD (LRRK2/Luebeck International Parkinson's Disease) Study Protocol: Deep Phenotyping of an International Genetic Cohort
Usnich, Tatiana; Vollstedt, Eva-Juliane; Schell, Nathalie et al

in Frontiers in Neurology (2021), 12

Background: Pathogenic variants in the Leucine-rich repeat kinase 2 ( LRRK2) gene are the most common known monogenic cause of Parkinson's disease (PD). LRRK2 -linked PD is clinically indistinguishable ... [more ▼]

Background: Pathogenic variants in the Leucine-rich repeat kinase 2 ( LRRK2) gene are the most common known monogenic cause of Parkinson's disease (PD). LRRK2 -linked PD is clinically indistinguishable from idiopathic PD and inherited in an autosomal dominant fashion with reduced penetrance and variable expressivity that differ across ethnicities and geographic regions. Objective: To systematically assess clinical signs and symptoms including non-motor features, comorbidities, medication and environmental factors in PD patients, unaffected LRRK2 pathogenic variant carriers, and controls. A further focus is to enable the investigation of modifiers of penetrance and expressivity of LRRK2 pathogenic variants using genetic and environmental data. Methods: Eligible participants are invited for a personal or online examination which comprises completion of a detailed eCRF and collection of blood samples (to obtain DNA, RNA, serum/plasma, immune cells), urine as well as household dust. We plan to enroll 1,000 participants internationally: 300 with LRRK2 -linked PD, 200 with LRRK2 pathogenic variants but without PD, 100 PD patients with pathogenic variants in the GBA or PRKN genes, 200 patients with idiopathic PD, and 200 healthy persons without pathogenic variants. Results: The eCRF consists of an investigator-rated (1 h) and a self-rated (1.5 h) part. The first part includes the Movement Disorder Society Unified Parkinson's Disease Rating, Hoehn \&Yahr, and Schwab \& England Scales, the Brief Smell Identification Test, and Montreal Cognitive Assessment. The self-rating part consists of a PD risk factor, food frequency, autonomic dysfunction, and quality of life questionnaires, the Pittsburgh Sleep Quality Inventory, and the Epworth Sleepiness as well as the Hospital Anxiety and Depression Scales. The first 15 centers have been initiated and the first 150 participants enrolled (as of March 25th, 2021). Conclusions: LIPAD is a large-scale international scientific effort focusing on deep phenotyping of LRRK2 -linked PD and healthy pathogenic variant carriers, including the comparison with additional relatively frequent genetic forms of PD, with a future perspective to identify genetic and environmental modifiers of penetrance and expressivity Clinical Trial Registration: ClinicalTrials.gov , NCT04214509. [less ▲]

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See detailTUMOUR-ASSOCIATED MICROGLIA/MACROPHAGE HETEROGENEITY IN GLIOBLASTOMA
Pires Afonso, Yolanda Sofia UL

Doctoral thesis (2021)

Glioblastoma (GBM) is the most common and aggressive primary brain tumour in adults, characterized by high degrees of both inter- and intra-tumour heterogeneity. GBM cells secrete numerous factors ... [more ▼]

Glioblastoma (GBM) is the most common and aggressive primary brain tumour in adults, characterized by high degrees of both inter- and intra-tumour heterogeneity. GBM cells secrete numerous factors promoting the recruitment and infiltration of cellular players to the local tumour microenvironment. Tumour-associated microglia/macrophages (TAMs) represent the major cell type of the stromal compartment in GBM playing important roles along tumour development. Along GBM progression, these cells are supposed to be geared towards a tumour-supportive phenotype, therefore TAMs are pursued as key targets for the development of novel strategies aimed at re-educating them towards anti-tumour phenotypes. However, it is yet unclear how these immune suppressive properties are acquired and whether TAM subsets may phenotypically and functionally differently contribute to tumour development. Hence, the main goal of the present PhD project was to elucidate TAM diversity under defined temporal and spatial settings in GBM. Taking advantage of the GBM GL261 syngeneic and patient-derived orthotopic xenograft mouse models, we comprehensively studied the cellular and transcriptional heterogeneity of TAMs by combining single-cell RNA-sequencing, multicolour flow cytometry, immunohistological and functional analyses. We demonstrated that, as observed in patients, the myeloid compartment is the most affected and heterogeneous stromal compartment, with microglia and macrophage-like cells acquiring key transcriptional differences and rapidly adapting along GBM progression. Specifically, we uncovered that TAM transcriptional programmes converge over time, suggesting a context-dependent symbiosis mechanism characterized by decreased antigen-presenting cell signatures at late tumour stages. In the absence of Acod1/Irg1, a key gene involved in the metabolic reprogramming of macrophages towards an anti-inflammatory phenotype, we detected higher TAM diversity in the TME displaying increased immunogenicity and correlating with increased lymphocytic recruitment to the tumour site. Additionally, we uncovered that TAMs exhibit niche-specific functional adaptations in the tumour microenvironment, with microglia in the invasive landscapes displaying higher immune reactive profiles when compared to the corresponding cells in the angiogenic tumour phenotypes. Taken together, our data provide insights into the spatial and molecular heterogeneity of TAMs dynamically adapting along tumour progression or across specific tumour sites and revealing potential reactive anti-tumorigenic cell subsets that may be harnessed for therapeutic intervention in GBM. [less ▲]

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See detailDevelopment and Application of Liquid Chromatographic Retention Time Indices in HRMS-Based Suspect and Nontarget Screening
Aalizadeh, Reza; Alygizakis, Nikiforos A.; Schymanski, Emma UL et al

in Analytical Chemistry (2021), 93(33), 11601--11611

There is an increasing need for comparable and harmonized retention times (tR) in liquid chromatography (LC) among different laboratories, to provide supplementary evidence for the identity of compounds ... [more ▼]

There is an increasing need for comparable and harmonized retention times (tR) in liquid chromatography (LC) among different laboratories, to provide supplementary evidence for the identity of compounds in high-resolution mass spectrometry (HRMS)-based suspect and nontarget screening investigations. In this study, a rigorously tested, flexible, and less system-dependent unified retention time index (RTI) approach for LC is presented, based on the calibration of the elution pattern. Two sets of 18 calibrants were selected for each of ESI+ and ESI-based on the maximum overlap with the retention times and chemical similarity indices from a total set of 2123 compounds. The resulting calibration set, with RTI set to range between 1 and 1000, was proposed as the most appropriate RTI system after rigorous evaluation, coordinated by the NORMAN network. The validation of the proposed RTI system was done externally on different instrumentation and LC conditions. The RTI can also be used to check the reproducibility and quality of LC conditions. Two quantitative structure−retention relationship (QSRR)-based models were built based on the developed RTI systems, which assist in the removal of false-positive annotations. The applicability domains of the QSRR models allowed completing the identification process with higher confidence for substances within the domain, while indicating those substances for which results should be treated with caution. The proposed RTI system was used to improve confidence in suspect and nontarget screening and increase the comparability between laboratories as demonstrated for two examples. All RTI-related calculations can be performed online at http://rti.chem.uoa.gr/. [less ▲]

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See detail#gemeinsamlesen: Raptexte online kommentieren und diskutieren. Unterrichtsmaterialien für den Deutschunterricht
Baumann, Isabell Eva UL

in Programme for Innovative Teaching and Training (PITT) (2021)

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See detailPodcast Café du Savoir. Episode 1: PITT– Programme for Innovative Teaching & Training
Baumann, Isabell Eva UL; Bissen, Manuel; Harion, Dominic UL et al

Speeches/Talks (2021)

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See detailDon’t Put the Cart Before the Horse – Effective Incident Handling Under GDPR and NIS Directive
Schmitz, Sandra UL; Schiffner, Stefan UL

in Friedewald, Michael; Schiffner, Stefan; Krenn, Stephan (Eds.) Privacy and Identity Management (2021)

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See detailTagungsbericht: Rethinking the Histories and Legacies of Industrial Cities
Derian, Maxime UL; van de Maele, Jens UL

in Moderne Stadtgeschichte (2021), (1), 145-150

The history of (Western) European industrial cities is often told as a tragic tale of rise and decline: from rapid industrialisation in the late 19th century and economic prosperity during the Trente ... [more ▼]

The history of (Western) European industrial cities is often told as a tragic tale of rise and decline: from rapid industrialisation in the late 19th century and economic prosperity during the Trente glorieuses to the structural changes of the late 1970s and the subsequent deindustrialisation of the 1980s and 1990s – decades in which most mines and steelworks closed down, unemployment rates went up, new social problems emerged, workers’ identities eroded, and once prosperous urban centres became faced with shrinking populations and empty stores in their shopping streets. Finally, since the 2000s, former industrial towns have tried to reinvent themselves as creative and cultural centres. If we take a closer look, however, we can see that the socio-economic, demographic and cultural transitions were more complex than suggested by a simple rise-and-decline narrative. [less ▲]

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See detailPolicy Brief – Le Capital Social : les Facilitateurs et les Obstacles à l’Intégration des Jeunes Migrants au Luxembourg
Vysotskaya, Volha UL; Oliveira, José UL; Nienaber, Birte UL

Report (2021)

The Policy Brief opposite is based on the results of the SOCAMI project, which was drawn up on the basis of secondary analysis of European and national data concerning the socio-professional integration ... [more ▼]

The Policy Brief opposite is based on the results of the SOCAMI project, which was drawn up on the basis of secondary analysis of European and national data concerning the socio-professional integration of young migrants, as well as qualitative data collected as part of this study. Indeed, twelve biographical interviews were conducted by the researchers involved in the project with young migrants who had been living in Luxembourg for more than five years. This analysis was completed by eight expert interviews with representatives of organisations working with young people and/or migrants in various fields. These different analyses made it possible, on the one hand, to develop relevant indicators to measure the acquisition of social capital by young migrants and, on the other hand, to identify the structural obstacles to the social integration of this group. Based on these results, this document makes a number of recommendations for governmental and non-governmental organisations working with young people and/or migrants. [less ▲]

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See detailSNR-Based GNSS-R for Coastal Sea-Level Altimetry
Tabibi, Sajad UL; Sauveur, Renaldo UL; Guerrier, Kelly et al

in Geosciences (2021), 11(9 391),

Geodetic Global Navigation Satellite System reflectometry (GNSS-R) uses ground-based signals of opportunity to retrieve sea levels at an intermediate spatial scale. Geodetic GNSS-R is based on the ... [more ▼]

Geodetic Global Navigation Satellite System reflectometry (GNSS-R) uses ground-based signals of opportunity to retrieve sea levels at an intermediate spatial scale. Geodetic GNSS-R is based on the simultaneous reception of Line-of-Sight (LoS) and its coherent GNSS sea surface reflection (non-LOS) signals. The scope of this paper is to present geodetic GNSS-R applied to sea level altimetry. Signal-to-Noise Ratio (SNR) measurements from a Commercial Off-The-Shelf (COTS) geodetic-quality GNSS station at the Haiti Coast Guard Base in Port-au-Prince is used to retrieve sea levels in the International Terrestrial Reference Frame 2014 (ITRF2014). The GNSS-R sea levels are compared with those of the OTT Radar Level Sensor (RLS) installed vertically below the GNSS antenna. The Root-Mean-Square Error (RMSE) between the geodetic GNSS-R sea levels and OTT RLS records is 3.43 cm, with a correlation of 0.96. In addition, the complex differences between the OTT RLS records and 15-min GNSS-R sea levels using Global Positioning System (GPS) and Globalnaya Navigazionnaya Sputnikovaya Sistema (or Global Navigation Satellite System; GLONASS) signals for all the eight major tidal constituents are in mm-level agreement. Therefore, geodetic GNSS-R can be used as a complementary approach to the conventional method for sea level studies in a stable terrestrial reference frame. [less ▲]

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See detailDiagnostics and correction of batch effects in large-scale proteomic studies: a tutorial.
Čuklina, Jelena; Lee, Chloe H.; Williams, Evan UL et al

in Molecular systems biology (2021), 17(8), 10240

Advancements in mass spectrometry-based proteomics have enabled experiments encompassing hundreds of samples. While these large sample sets deliver much-needed statistical power, handling them introduces ... [more ▼]

Advancements in mass spectrometry-based proteomics have enabled experiments encompassing hundreds of samples. While these large sample sets deliver much-needed statistical power, handling them introduces technical variability known as batch effects. Here, we present a step-by-step protocol for the assessment, normalization, and batch correction of proteomic data. We review established methodologies from related fields and describe solutions specific to proteomic challenges, such as ion intensity drift and missing values in quantitative feature matrices. Finally, we compile a set of techniques that enable control of batch effect adjustment quality. We provide an R package, "proBatch", containing functions required for each step of the protocol. We demonstrate the utility of this methodology on five proteomic datasets each encompassing hundreds of samples and consisting of multiple experimental designs. In conclusion, we provide guidelines and tools to make the extraction of true biological signal from large proteomic studies more robust and transparent, ultimately facilitating reliable and reproducible research in clinical proteomics and systems biology. [less ▲]

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See detailMolecular pathways behind acquired obesity: Adipose tissue and skeletal muscle multiomics in monozygotic twin pairs discordant for BMI.
van der Kolk, Birgitta W.; Saari, Sina; Lovric, Alen et al

in Cell reports. Medicine (2021), 2(4), 100226

Tissue-specific mechanisms prompting obesity-related development complications in humans remain unclear. We apply multiomics analyses of subcutaneous adipose tissue and skeletal muscle to examine the ... [more ▼]

Tissue-specific mechanisms prompting obesity-related development complications in humans remain unclear. We apply multiomics analyses of subcutaneous adipose tissue and skeletal muscle to examine the effects of acquired obesity among 49 BMI-discordant monozygotic twin pairs. Overall, adipose tissue appears to be more affected by excess body weight than skeletal muscle. In heavier co-twins, we observe a transcriptional pattern of downregulated mitochondrial pathways in both tissues and upregulated inflammatory pathways in adipose tissue. In adipose tissue, heavier co-twins exhibit lower creatine levels; in skeletal muscle, glycolysis- and redox stress-related protein and metabolite levels remain higher. Furthermore, metabolomics analyses in both tissues reveal that several proinflammatory lipids are higher and six of the same lipid derivatives are lower in acquired obesity. Finally, in adipose tissue, but not in skeletal muscle, mitochondrial downregulation and upregulated inflammation are associated with a fatty liver, insulin resistance, and dyslipidemia, suggesting that adipose tissue dominates in acquired obesity. [less ▲]

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See detailA platform for experimental precision medicine: The extended BXD mouse family.
Ashbrook, David G.; Arends, Danny; Prins, Pjotr et al

in Cell systems (2021), 12(3), 235-2479

The challenge of precision medicine is to model complex interactions among DNA variants, phenotypes, development, environments, and treatments. We address this challenge by expanding the BXD family of ... [more ▼]

The challenge of precision medicine is to model complex interactions among DNA variants, phenotypes, development, environments, and treatments. We address this challenge by expanding the BXD family of mice to 140 fully isogenic strains, creating a uniquely powerful model for precision medicine. This family segregates for 6 million common DNA variants-a level that exceeds many human populations. Because each member can be replicated, heritable traits can be mapped with high power and precision. Current BXD phenomes are unsurpassed in coverage and include much omics data and thousands of quantitative traits. BXDs can be extended by a single-generation cross to as many as 19,460 isogenic F1 progeny, and this extended BXD family is an effective platform for testing causal modeling and for predictive validation. BXDs are a unique core resource for the field of experimental precision medicine. [less ▲]

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