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See detailSECAT: Quantifying Protein Complex Dynamics across Cell States by Network-Centric Analysis of SEC-SWATH-MS Profiles.
Rosenberger, George; Heusel, Moritz; Bludau, Isabell et al

in Cell systems (2020), 11(6), 589-6078

Protein-protein interactions (PPIs) play critical functional and regulatory roles in cellular processes. They are essential for macromolecular complex formation, which in turn constitutes the basis for ... [more ▼]

Protein-protein interactions (PPIs) play critical functional and regulatory roles in cellular processes. They are essential for macromolecular complex formation, which in turn constitutes the basis for protein interaction networks that determine the functional state of a cell. We and others have previously shown that chromatographic fractionation of native protein complexes in combination with bottom-up mass spectrometric analysis of consecutive fractions supports the multiplexed characterization and detection of state-specific changes of protein complexes. In this study, we extend co-fractionation and mass spectrometric data analysis to perform quantitative, network-based studies of proteome organization, via the size-exclusion chromatography algorithmic toolkit (SECAT). This framework explicitly accounts for the dynamic nature and rewiring of protein complexes across multiple cell states and samples, thus, elucidating molecular mechanisms that are differentially implemented across different experimental settings. Systematic analysis of multiple datasets shows that SECAT represents a highly scalable and effective methodology to assess condition/state-specific protein-network state. A record of this paper's transparent peer review process is included in the Supplemental Information. [less ▲]

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See detailBody weight and high-fat diet are associated with epigenetic aging in female members of the BXD murine family.
Sandoval-Sierra, Jose Vladimir; Helbing, Alexandra H. B.; Williams, Evan UL et al

in Aging cell (2020), 19(9), 13207

DNA methylation (DNAm) is shaped by genetic and environmental factors and modulated by aging. Here, we examine interrelations between epigenetic aging, body weight (BW), and life span in 12 isogenic ... [more ▼]

DNA methylation (DNAm) is shaped by genetic and environmental factors and modulated by aging. Here, we examine interrelations between epigenetic aging, body weight (BW), and life span in 12 isogenic strains from the BXD family of mice that exhibit over twofold variation in longevity. Genome-wide DNAm was assayed in 70 liver specimens from predominantly female cases, 6-25 months old, that were maintained on normal chow or high-fat diet (HFD). We defined subsets of CpG regions associated with age, BW at young adulthood, and strain-by-diet-dependent life span. These age-associated differentially methylated CpG regions (age-DMRs) featured distinct genomic characteristics, with DNAm gains over time occurring in sites such as promoters and exons that have high CpG density and low average methylation. CpG regions associated with BW were enriched in introns, tended to have lower methylation in mice with higher BW, and were inversely correlated with gene expression (i.e., higher mRNA levels in mice with higher BW). CpG regions associated with life span were linked to genes involved in life span modulation, including the telomerase reverse transcriptase gene, Tert, which had both lower methylation and higher expression in long-lived strains. An epigenetic clock defined from age-DMRs revealed accelerated aging in mice belonging to strains with shorter life spans. Both higher BW and the HFD were associated with accelerated epigenetic aging. Our results highlight the age-accelerating effect of heavier BW. Furthermore, we demonstrate that the measure of epigenetic aging derived from age-DMRs can predict genotype and diet-induced differences in life span among female BXD members. [less ▲]

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See detailPourquoi les Amish ? Retour sur un stéréotype
Weis, Monique UL

Article for general public (2020)

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See detailIl y a quatre cents ans… le Mayflower (1620-2020)
Weis, Monique UL

Article for general public (2020)

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See detailTransforming Unitary States into Federations: Path-Dependent Construction of Political Identities in Belgium and Lebanon
Farhat, Nadim UL; Vloeberghs, Ward; Bourbeau, Philippe et al

in Publius: the Journal of Federalism (2020), 50(4), 593619

The theory of congruence in comparative federalism holds that institutional design will, eventually, reflect societal divisions by transferring central powers to new, autonomous entities. While this model ... [more ▼]

The theory of congruence in comparative federalism holds that institutional design will, eventually, reflect societal divisions by transferring central powers to new, autonomous entities. While this model helps to understand why many divided societies adopt federalism, it cannot explain why only certain unitary states transform into federal ones while others do not. We use a historical institutionalism approach to identify the critical junctures in the trajectory of two prominent plural polities, Belgium and Lebanon. We suggest that the politicization of identities during initial stages of state-building plays a major role in the transformation of a unitary state into a federation—which occurs in the former but not in the latter of our cases. The current contrast in both consociational democracies is explained here as a legacy of the late nineteenth century, which set in motion decisive logics of public governance that direct institutional dynamics until today. [less ▲]

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See detailScheduling Flexible Demand in Cloud Computing Spot Markets
Keller, Robert; Häfner, Lukas; Sachs, Thomas et al

in Business and Information Systems Engineering (2020), 62(1), 25--39

The rapid standardization and specialization of cloud computing services have led to the development of cloud spot markets on which cloud service providers and customers can trade in near real-time ... [more ▼]

The rapid standardization and specialization of cloud computing services have led to the development of cloud spot markets on which cloud service providers and customers can trade in near real-time. Frequent changes in demand and supply give rise to spot prices that vary throughout the day. Cloud customers often have temporal flexibility to execute their jobs before a specific deadline. In this paper, the authors apply real options analysis (ROA), which is an established valuation method designed to capture the flexibility of action under uncertainty. They adapt and compare multiple discrete-time approaches that enable cloud customers to quantify and exploit the monetary value of their short-term temporal flexibility. The paper contributes to the field by guaranteeing cloud job execution of variable-time requests in a single cloud spot market, whereas existing multi-market strategies may not fulfill requests when outbid. In a broad simulation of scenarios for the use of Amazon EC2 spot instances, the developed approaches exploit the existing savings potential up to 40 percent – a considerable extent. Moreover, the results demonstrate that ROA, which explicitly considers time-of-day-specific spot price patterns, outperforms traditional option pricing models and expectation optimization. [less ▲]

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See detailFelix Calonder (1863–1952)
Erpelding, Michel UL

in Galerie des internationalistes francophones (2020)

Biographical note on Felix Calonder, Swiss statesman and international law practitioner, President of the highly innovative Mixed Commission for Upper Silesia (1922-1937) and author of the first coherent ... [more ▼]

Biographical note on Felix Calonder, Swiss statesman and international law practitioner, President of the highly innovative Mixed Commission for Upper Silesia (1922-1937) and author of the first coherent body of international case law on individual rights. Published as part of the French Society of International Law's Gallery of International Lawyers. [less ▲]

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See detailUne conséquence méconnue du Traité de Versailles : Le régime de protection des minorités en Haute-Silésie (1922-1937)
Erpelding, Michel UL

in Castellarin, Emanuel; Hamman, Andrea (Eds.) Le Traité de Versailles : Regards franco-allemands en droit international à l’occasion du centenaire/The Versailles Treaty: French and German Perspectives in International Law on the Occasion of the Centenary (2020)

This book chapter presents and critically assesses the international regime for the protection of ethnic and religious minorities established between Germany and Poland in Upper Silesia between 1922 and ... [more ▼]

This book chapter presents and critically assesses the international regime for the protection of ethnic and religious minorities established between Germany and Poland in Upper Silesia between 1922 and 1937. [less ▲]

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See detailArbitral Tribunal for Upper Silesia
Erpelding, Michel UL; Irurzun, Fernando

in Ruiz Fabri, Helene (Ed.) Max Planck Encyclopedia of International Procedural Law (2020)

This entry provides a detailed description and assessment of the Arbitral Tribunal for Upper Silesia, arguably the most sophisticated international court of the interwar period.

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See detailMixed Court of Tangier
Erpelding, Michel UL; Rherrousse, Fouzi

in Ruiz Fabri, Helene (Ed.) Max Planck Encyclopedia of International Procedural Law (2020)

This entry provides a detailed account and assessment of the Mixed Court of Tangier (1925-1956), a mixed court of the colonial era established in the International Zone of Tangier as a replacement for ... [more ▼]

This entry provides a detailed account and assessment of the Mixed Court of Tangier (1925-1956), a mixed court of the colonial era established in the International Zone of Tangier as a replacement for consular courts. Like the better-known Mixed Courts of Egypt, the Mixed Court of Tangier had the mandate to protect the treaty-based individual rights of foreigners against any infringements by the local authorities. [less ▲]

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See detailA stereo perception framework for autonomous vehicles
Kemsaram, Narsimlu UL; Das, Anweshan; Dubbelman, Gijs

in 2020 IEEE 91st Vehicular Technology Conference (VTC2020-Spring) (2020)

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See detailSingle-cell sequencing of the human midbrain reveals glial activation and a neuronal state specific to Parkinson’s disease
Smajic, Semra UL; Prada-Medina, Cesar A.; Landoulsi, Zied UL et al

E-print/Working paper (2020)

Parkinson’s disease (PD) etiology is associated with genetic and environmental factors that lead to a loss of dopaminergic neurons. However, the functional interpretation of PD-associated risk variants ... [more ▼]

Parkinson’s disease (PD) etiology is associated with genetic and environmental factors that lead to a loss of dopaminergic neurons. However, the functional interpretation of PD-associated risk variants and how other midbrain cells contribute to this neurodegenerative process are poorly understood. Here, we profiled >41,000 single-nuclei transcriptomes of postmortem midbrain tissue from 6 idiopathic PD (IPD) patients and 5 matched controls. We show that PD-risk variants are associated with glia- and neuron-specific gene expression patterns. Furthermore, Microglia and astrocytes presented IPD-specific cell proliferation and dysregulation of genes related to unfolded protein response and cytokine signalling. IPD-microglia revealed a specific pro-inflammatory trajectory. Finally, we discovered a neuronal cell cluster exclusively present in IPD midbrains characterized by CADPS2 overexpression and a high proportion of cycling cells. We conclude that elevated CADPS2 expression is specific to dysfunctional dopaminergic neurons, which have lost their dopaminergic identity and unsuccessful attempt to re-enter the cell cycle. [less ▲]

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See detailOn the Sixth International Olympiad in Cryptography NSUCRYPTO
Gorodilova, Anastasiya; Tokareva, Natalia N.; Agievich, Sergey et al

E-print/Working paper (2020)

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See detailLink Adaptation and SINR errors in Practical Multicast Multibeam Satellite Systems with Linear Precoding
Tato, Anxo; Andrenacci, Stefano; Lagunas, Eva UL et al

in International Journal of Satellite Communications and Networking (2020)

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See detailA Novel Methodology for the Scalability Analysis of ICT Systems for Smart Grids Based on SGAM: The InteGrid Project Approach
Potenciano Menci, Sergio UL; Le Baut, Julien; Matanza Domingo, Javier et al

in Energies (2020), 13(15 3818),

Information and Communication Technology (ICT) infrastructures are at the heart of emerging Smart Grid scenarios with high penetration of Distributed Energy Resources (DER). The scalability of such ICT ... [more ▼]

Information and Communication Technology (ICT) infrastructures are at the heart of emerging Smart Grid scenarios with high penetration of Distributed Energy Resources (DER). The scalability of such ICT infrastructures is a key factor for the large scale deployment of the aforementioned Smart Grid solutions, which could not be ensured by small-scale pilot demonstrations. This paper presents a novel methodology that has been developed in the scope of the H2020 project InteGrid, which enables the scalability analysis of ICT infrastructures for Smart Grids. It is based on the Smart Grid Architecture Model (SGAM) framework, which enables a standardized and replicable approach. This approach consists of two consecutive steps: a qualitative analysis that aims at identifying potential bottlenecks in an ICT infrastructure; and a quantitative analysis of the identified critical links under stress conditions by means of simulations with the aim of evaluating their operational limits. In this work the proposed methodology is applied to a cluster of solutions demonstrated in the InteGrid Slovenian pilot. This pilot consists of a Large Customer Commercial Virtual Power Plant (VPP) that provides flexibility in medium voltage for tertiary reserve and a Traffic Light System (TLS) to validate such flexibility offers. This approach creates an indirect Transmission System Operator (TSO)—Distribution System Operator (DSO) coordination scheme. [less ▲]

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See detailFrom Digitized Sources to Digital Data, Behind the Scenes of (Critically) Enriching a Digital Heritage Collection
Viola, Lorella UL; Fiscarelli, Antonio Maria

in Weber, Andreas; Heerlien, Maarten; Gassó Miracle, Eulàlia (Eds.) et al Proceedings of the International Conference Collect and Connect: Archives and Collections in a Digital Age (2020)

Digitally available repositories are becoming not only more and more widespread but also larger and larger. Although there are both digitally-born collections and digitised material, the digital heritage ... [more ▼]

Digitally available repositories are becoming not only more and more widespread but also larger and larger. Although there are both digitally-born collections and digitised material, the digital heritage scholar is typically confronted with the latter. This immediately presents new challenges, one of the most urgent being how to find the meaningful elements that are hidden underneath such unprecedented mass of digital data. One way to respond to this challenge is to contextually enrich the digital material, for example through deep learning. Using the enrichment of the digital heritage collection ChroniclItaly 3.0 [10] as a concrete example, this article discusses the complexities of this process. Specifically, combining statistical and critical evaluation, it describes the gains and losses resulting from the decisions made by the researcher at each step and it shows how in the passage from digitised sources to enriched material, most is gained (e.g., preservation, wider and enhanced access, more material) but some is also lost (e.g., original layout and composition, loss of information due to pre-processing steps). The article concludes that it is only through a critical approach that the digital heritage scholar can successfully meet the interpretive challenges presented by the digital and the digital heritage sector fulfil the second most important purpose of digitisation, that is to enhance access. [less ▲]

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See detailDe quelques spécificités des « guerres de religion »
Weis, Monique UL

Article for general public (2020)

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See detailBlackout analysis of Mars entry missions
Ramjatan, Sahadeo; Lani, Andrea; Boccelli, Stefan et al

in Journal of Fluid Mechanics (2020)

A new methodology to accurately and efficiently examine the radio frequency blackout phenomenon during the hypersonic reentry process is introduced and validated. The current state-of-the-art ... [more ▼]

A new methodology to accurately and efficiently examine the radio frequency blackout phenomenon during the hypersonic reentry process is introduced and validated. The current state-of-the-art thermochemical modelling of CO2 flows is reviewed and one-dimensional stagnation line studies are performed in order to determine a suitable chemical mechanism for the electron density modelling. Hypersonic computational fluid dynamics (CFD) simulations are performed with a simplified chemical model including only neutral species, in order to calculate the flow field surrounding the ExoMars Schiapparelli module in flight conditions. A novel decoupled CFD approach is then applied where the calculation of the electron density is performed separately using a computationally inexpensive Lagrangian approach. Subsequently, a ray tracing algorithm is applied in order to model the propagation of electromagnetic waves in the wake flow past the ExoMars vehicle accounting for collisions between electrons and gas particles. The numerical results of the proposed novel approach for blackout analysis consisting of CFD, Lagrangian and ray tracing algorithms are in good agreement with the flight data. [less ▲]

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See detailThe Colonial Situation in Practice: Food at the Albert Schweitzer Hospital, Lambaréné 1924-65.
Zumthurm, Tizian UL

in International Journal of African Historical Studies (2020)

Detailed reference viewed: 17 (1 UL)