Last 7 days
Bookmark and Share    
Full Text
Peer Reviewed
See detailResponsible Vulnerability Disclosure under the NIS 2.0 Proposal
Schmitz, Sandra UL; Schiffner, Stefan UL

in Journal of Intellectual Property, Information Technology and E-Commerce Law (2021), 12(5),

Detailed reference viewed: 26 (4 UL)
See detailSchloss Malberg - Das Barockjuwel in der Südeifel
Solchenbach, Karl UL

Book published by Förderverein Schloss Malberg (2021)

Detailed reference viewed: 31 (0 UL)
Full Text
Peer Reviewed
See detailHow photoluminescence can predict the efficiency of solar cells
Siebentritt, Susanne UL; Weiss, Thomas UL; Sood, Mohit UL et al

in JPhys Materials (2021)

Detailed reference viewed: 59 (2 UL)
Full Text
Peer Reviewed
See detailSimilarities and Differences in How Supervisors at Canadian and UK Institutions Understand Doctoral Supervision.
Kreber, Carolin; Wealer, Cyril UL; Heather, Kanuka

in International Journal of Doctoral Studies (2021), (16), 657-688

Detailed reference viewed: 29 (4 UL)
Full Text
See detailGDAP1 loss of function inhibits the mitochondrial pyruvate dehydrogenase complex by altering the actin cytoskeleton 2021.03.04.433895
Wolf, Christina; Pouya, Alireza; Bitar, Sara et al

E-print/Working paper (2021)

Charcot-Marie-Tooth (CMT) disease 4A is an autosomal-recessive polyneuropathy caused by mutations of ganglioside-induced differentiation-associated protein 1 (GDAP1), a putative glutathione transferase ... [more ▼]

Charcot-Marie-Tooth (CMT) disease 4A is an autosomal-recessive polyneuropathy caused by mutations of ganglioside-induced differentiation-associated protein 1 (GDAP1), a putative glutathione transferase, which affects mitochondrial shape and alters cellular Ca2+ homeostasis. Here, we identify the underlying mechanism. We found that patient-derived motoneurons and GDAP1 knockdown SH-SY5Y cells display two phenotypes: more tubular mitochondria and a metabolism characterized by glutamine dependence and fewer cytosolic lipid droplets. GDAP1 interacts with the actin-depolymerizing protein Cofilin-1 in a redoxdependent manner, suggesting a role for actin signaling. Consistently, GDAP1 loss causes less F-actin close to mitochondria, which restricts mitochondrial localization of the fission factor dynamin-related protein 1, instigating tubularity. Changes in the actin cytoskeleton also disrupt mitochondria-ER contact sites. This results in lower mitochondrial Ca2+ levels and inhibition of the pyruvate dehydrogenase complex, explaining the metabolic changes upon GDAP1 loss of function. Together, these findings reconcile GDAP1-associated phenotypes and implicate disrupted actin signaling in CMT4A pathophysiology. [less ▲]

Detailed reference viewed: 35 (2 UL)
See detailGesundheit als Metapher. Über die ästhetischen Dimensionen eines nicht nur medizinischen Begriffs
Bendheim, Amelie UL; Jennifer, Pavlik

in Bendheim, Amelie; Pavlik, Jennifer (Eds.) Gesundheit als Metapher (2021)

Detailed reference viewed: 42 (0 UL)
Full Text
Peer Reviewed
See detailThe Cost of No Reform: Assessing the Impact of Different Electricity Pricing Regimes on Indonesia\textquoterights Energy Trilemma
Heffron, Raphael; Körner, Marc Fabian; Sumarno, Theresia et al

E-print/Working paper (2021)

Many countries have a clear policy objective of increasing their share of renewable energy sources (RESs). However, a major impediment to higher RES penetration often lies in the historically grown ... [more ▼]

Many countries have a clear policy objective of increasing their share of renewable energy sources (RESs). However, a major impediment to higher RES penetration often lies in the historically grown structures of a country\textquoterights electricity sector. In Indonesia, policy makers have relied on cheap fossil fuels and state control to provide the population with access to both reliable and affordable electricity. However, this focus on only two of the three horns of the energy trilemma, namely energy security and energy equity (and not sustainability), may put Indonesia at risk of missing its ambitious RES targets. In this context, a number of small-scale reform attempts to promote RES integration in recent years have proved to be relatively unsuccessful. Like many other countries, Indonesia needs clear policy directions to avoid an unsustainable lock-in into a fossil fuel future. In the last decades, several other countries have successfully restructured their electricity sectors, for example by introducing a wholesale market for electricity under different electricity pricing systems, including nodal, zonal, or uniform pricing. These countries may hold valuable experiences of overcoming the historically grown barriers to successful RES integration through a greater role for market mechanisms. We develop three generic models that allow policy makers to analyze the impact of introducing either a nodal, a zonal, or a uniform pricing system on the three horns of the energy trilemma in their country. We evaluate our model using a simplified network representation of the Indonesian electricity sector. Our results indicate that each of the pricing systems is able to foster specific horns of the energy trilemma. Considering that any major reform intended to improve energy sustainability in Indonesia will only be a success if it also addresses energy security and energy equity, we also discuss our results from the perspective of energy justice and the need to balance the country\textquoterights energy trilemma. Ultimately, we illustrate a transformation pathway for a more sustainable and just transition to a low-carbon economy in Indonesia. [less ▲]

Detailed reference viewed: 53 (1 UL)
Full Text
Peer Reviewed
See detailPreface - Journal of Applied Logics
Gabbay, Dov M. UL; Giacomin, Massimiliano; Simari, Guillermo Ricardo et al

in IfCoLog Journal of Logics and Their Applications (2021), 8(6), 1335-1338

Detailed reference viewed: 27 (0 UL)
Full Text
Peer Reviewed
See detailCompte rendu de Sébastien Pierre et Ricahrd Jusseret (accord.), Du Piconrue à la Grande Ardenne. Hommage à André Neuberg
Pettiau, Hérold UL

in Hemecht: Zeitschrift für Luxemburger Geschichte (2021)

This is a review of a collection of essayas gathered in hommage to André Neuberg,founder of the "Musée en Piconrue" in Bastogne in the early 1980s. Numerous exhibitions have been organised dealing with ... [more ▼]

This is a review of a collection of essayas gathered in hommage to André Neuberg,founder of the "Musée en Piconrue" in Bastogne in the early 1980s. Numerous exhibitions have been organised dealing with aspects of religious history and patrimony in the Ardennes and the Province of Luxembourg. [less ▲]

Detailed reference viewed: 29 (1 UL)
Full Text
Peer Reviewed
See detailPattern Recognition and Reconstruction: Detecting Malicious Deletions in Textual Communications
Solanke, Abiodun; Chen, Xihui UL; Ramírez-Cruz, Yunior

in 2021 IEEE International Conference on Big Data (Big Data), Orlando, FL, USA, 15-18 December 2021 (2021)

Detailed reference viewed: 35 (0 UL)
Full Text
Peer Reviewed
See detailUne méthodologie adaptée pour mesurer l’évolution des compétences transversales des étudiants lors de mobilités internationales
Lejot, Eve UL; Molostoff, Leslie UL

in Les Revues Synergies du GERFLINT SYNERGIES PAYS GERMANOPHONES (2021), 14

The transversal skills developed during academic mobility periods equip students to meet the expectations of recruiters as they embark on professional life (Brandenburg, 2014: 3). With the COVID-19 ... [more ▼]

The transversal skills developed during academic mobility periods equip students to meet the expectations of recruiters as they embark on professional life (Brandenburg, 2014: 3). With the COVID-19 pandemic disrupting many mobility programmes, is it still possible for students to acquire these skills? The very nature of academic mobility has changed, with most mobility periods becoming partly virtual because teaching is mainly provided online. In this article, drawing on the results of the RECTEC+ project, we aim to propose a method to identify the transversal skills developed by mobility students at the University of Luxembourg despite the impact of COVID-19. [less ▲]

Detailed reference viewed: 74 (1 UL)
Full Text
Peer Reviewed
See detailStructural Plasticity of Dopaminergic Neurons Requires the Activation of the D3R-nAChR Heteromer and the PI3K-ERK1/2/Akt-Induced Expression of c-Fos and p70S6K Signaling Pathway
Mutti, Veronica; Bono, Federica; Tomasoni, Zaira et al

in Molecular Neurobiology (2021)

Detailed reference viewed: 28 (0 UL)
Full Text
Peer Reviewed
See detailA Triple Combination of Targeting Ligands Increases the Penetration of Nanoparticles across a Blood-Brain Barrier Culture Model
Veszelka, Szilvia; Mészáros, Mária; Porkoláb, Gergő et al

in Pharmaceutics (2021)

Detailed reference viewed: 37 (0 UL)
Full Text
Peer Reviewed
See detailThe benefits, costs and feasibility of a low incidence COVID-19 strategy
Czypionka, T.; Iftekhar, E.; Prainsack, B. et al

in The Lancet Regional Health - Europe (2021), 12(100193),

In the summer of 2021, European governments removed most NPIs after experiencing prolonged second and third waves of the COVID-19 pandemic. Most countries failed to achieve immunization rates high enough ... [more ▼]

In the summer of 2021, European governments removed most NPIs after experiencing prolonged second and third waves of the COVID-19 pandemic. Most countries failed to achieve immunization rates high enough to avoid resurgence of the virus. Public health strategies for autumn and winter 2021 have ranged from countries aiming at low incidence by re-introducing NPIs to accepting high incidence levels. However, such high incidence strategies almost certainly lead to the very consequences that they seek to avoid: restrictions that harm people and economies. At high incidence, the important pandemic containment measure ‘test-trace-isolate-support’ becomes inefficient. At that point, the spread of SARS-CoV-2 and its numerous harmful consequences can likely only be controlled through restrictions. We argue that all European countries need to pursue a low incidence strategy in a coordinated manner. Such an endeavour can only be successful if it is built on open communication and trust. [less ▲]

Detailed reference viewed: 50 (2 UL)
Full Text
See detailLehen der Grafen von Luxemburg im 13. Jahrhundert (Großregion SaarLorLux)
Moulin, Philippe; Pauly, Michel UL; Caruso, Geoffrey UL et al

E-print/Working paper (2021)

The map "The fiefs of the counts of Luxembourg in the 13th century" represents an attempt at a cartographic visualisation of the active fiefs of the counts of Luxembourg between 1200 and 1310. The map was ... [more ▼]

The map "The fiefs of the counts of Luxembourg in the 13th century" represents an attempt at a cartographic visualisation of the active fiefs of the counts of Luxembourg between 1200 and 1310. The map was created within the framework of the Master thesis "Lehnsrecht, Lehnspolitik und Lehnshof der Grafen von Luxemburg im 13. Jahrhundert" and aims to visualise the presence, number and type of fiefs. [less ▲]

Detailed reference viewed: 48 (4 UL)
See detailLes infractions en matière de gestion de portefeuille, Chapitre 31
Riassetto, Isabelle UL

in Lamy Droit pénal des affaires (2021)

Detailed reference viewed: 23 (0 UL)
See detailFonds d'investissement alternatifs - FIA, chap. 43
Riassetto, Isabelle UL

in Lamy Droit du financement (2021)

Detailed reference viewed: 40 (1 UL)
Full Text
See detailThe EU Sustainable Finance Framework in Light of International Standards
Zetzsche, Dirk Andreas UL; Bodellini, Marco UL; Consiglio, Roberta

E-print/Working paper (2021)

Detailed reference viewed: 42 (4 UL)