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See detailDetection & Identification of On-Orbit Objects Using Machine Learning
Perez, Marcos; Mohamed Ali, Mohamed Adel UL; Garcia Sanchez, Albert UL et al

in European Conference on Space Debris (2021), 8(1),

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See detailSPACECRAFT RECOGNITION LEVERAGING KNOWLEDGE OF SPACE ENVIRONMENT: SIMULATOR, DATASET, COMPETITION DESIGN, AND ANALYSIS
Mohamed Ali, Mohamed Adel UL; Gaudilliere, Vincent UL; Ghorbel, Enjie UL et al

in 2021 IEEE International Conference on Image Processing (ICIP) (2021)

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See detailThe Hidden Lattice Problem
Notarnicola, Luca UL; Wiese, Gabor UL

E-print/Working paper (2021)

We consider the problem of revealing a small hidden lattice from the knowledge of a low-rank sublattice modulo a given sufficiently large integer -- the {\em Hidden Lattice Problem}. A central motivation ... [more ▼]

We consider the problem of revealing a small hidden lattice from the knowledge of a low-rank sublattice modulo a given sufficiently large integer -- the {\em Hidden Lattice Problem}. A central motivation of study for this problem is the Hidden Subset Sum Problem, whose hardness is essentially determined by that of the hidden lattice problem. We describe and compare two algorithms for the hidden lattice problem: we first adapt the algorithm by Nguyen and Stern for the hidden subset sum problem, based on orthogonal lattices, and propose a new variant, which we explain to be related by duality in lattice theory. Following heuristic, rigorous and practical analyses, we find that our new algorithm brings some advantages as well as a competitive alternative for algorithms for problems with cryptographic interest, such as Approximate Common Divisor Problems, and the Hidden Subset Sum Problem. Finally, we study variations of the problem and highlight its relevance to cryptanalysis. [less ▲]

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See detailParliamentary Scrutiny of Brexit in the EU-27 Pragmatic Cooperation with a Dominant European Parliament
Högenauer, Anna-Lena UL

in International Journal of Parliamentary Studies (2021), 1(2),

Concerns about a democratic deficit in the European Union reached new heights in recent years, as the organization has had to address a number of highly politicized challenges. In this context, the ... [more ▼]

Concerns about a democratic deficit in the European Union reached new heights in recent years, as the organization has had to address a number of highly politicized challenges. In this context, the question of how much oversight should be exercised by the European Parliament (ep) and national parliaments individually or collectively becomes increasingly salient. Against this background, this article argues that on the issue of Brexit the ep has been quick to carve out a role for itself. However, unlike in previous trade negotiations, national parliaments took a backseat on Brexit despite its potential impact on member states. This is largely due to the similarity of national and party positions on Brexit. In addition, the way the different interparliamentary bodies addressed Brexit reveals the limitations of these bodies in terms of their powers and the depth of their discussions. [less ▲]

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See detailThe Data Use Ontology to streamline responsible access to human biomedical datasets
Lawson, Jonathan; Cabili, Moran N.; Kerry, Giselle et al

in Cell Genomics (2021), 1(2),

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See detailGA4GH Passport standard for digital identity and access permissions
Voisin, Craig; Linden, Mikael; Dyke, Stephanie O. M. et al

in Cell Genomics (2021), 1(2),

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See detailUniversalité et rétroactivité en droit des sociétés
Conac, Pierre-Henri UL

in Mélanges en l’honneur du Professeur Gilbert Parleani (2021)

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See detailAustrian Limited: Die Pläne zur flexiblen Kapitalgesellschaft und die Reform des Gesellschaftsrechts
Conac, Pierre-Henri UL

in Der Gesellschafter (2021)

Der vorliegende Beitrag widmet sich der von der Regierung geplanten neuen Kapitalgesellschaftsform einer Austrian Limited.

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See detailDCcov: Repositioning of drugs and drug combinations for SARS-CoV-2 infected lung through constraint-based modeling.
Kishk, Ali UL; Pires Pacheco, Maria Irene UL; Sauter, Thomas UL

in iScience (2021), 24(11), 103331

The 2019 coronavirus disease (COVID-19) became a worldwide pandemic with currently no approved effective antiviral drug. Flux balance analysis (FBA) is an efficient method to analyze metabolic networks ... [more ▼]

The 2019 coronavirus disease (COVID-19) became a worldwide pandemic with currently no approved effective antiviral drug. Flux balance analysis (FBA) is an efficient method to analyze metabolic networks. Here, FBA was applied on human lung cells infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to reposition metabolic drugs and drug combinations against the virus replication within the host tissue. Making use of expression datasets of infected lung tissue, genome-scale COVID-19-specific metabolic models were reconstructed. Then, host-specific essential genes and gene pairs were determined through in silico knockouts that permit reducing the viral biomass production without affecting the host biomass. Key pathways that are associated with COVID-19 severity in lung tissue are related to oxidative stress, ferroptosis, and pyrimidine metabolism. By in silico screening of Food and Drug Administration (FDA)-approved drugs on the putative disease-specific essential genes and gene pairs, 85 drugs and 52 drug combinations were predicted as promising candidates for COVID-19 (https://github.com/sysbiolux/DCcov). [less ▲]

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See detailAstrocyte-Neuron Metabolic Crosstalk in Neurodegeneration: A Mitochondrial Perspective.
Mulica, Patrycja UL; Grünewald, Anne UL; Pereira, Sandro L.

in Frontiers in endocrinology (2021), 12

Converging evidence made clear that declining brain energetics contribute to aging and are implicated in the initiation and progression of neurodegenerative disorders such as Alzheimer's and Parkinson's ... [more ▼]

Converging evidence made clear that declining brain energetics contribute to aging and are implicated in the initiation and progression of neurodegenerative disorders such as Alzheimer's and Parkinson's disease. Indeed, both pathologies involve instances of hypometabolism of glucose and oxygen in the brain causing mitochondrial dysfunction, energetic failure and oxidative stress. Importantly, recent evidence suggests that astrocytes, which play a key role in supporting neuronal function and metabolism, might contribute to the development of neurodegenerative diseases. Therefore, exploring how the neuro-supportive role of astrocytes may be impaired in the context of these disorders has great therapeutic potential. In the following, we will discuss some of the so far identified features underlining the astrocyte-neuron metabolic crosstalk. Thereby, special focus will be given to the role of mitochondria. Furthermore, we will report on recent advancements concerning iPSC-derived models used to unravel the metabolic contribution of astrocytes to neuronal demise. Finally, we discuss how mitochondrial dysfunction in astrocytes could contribute to inflammatory signaling in neurodegenerative diseases. [less ▲]

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See detailInteroceptive Approaches to Embodiment Research
Schulz, André UL; Vögele, Claus UL

in Robinson, Michael D.; Thomas, Laura E. (Eds.) Handbook of Embodied Psychology: Thinking, Feeling, and Acting. (2021)

Interoception refers to the processing and perception of signals arising from inside the body. Currently, there are two alternative conceptualizations of interoception: (1) an ‘inclusive’ view considering ... [more ▼]

Interoception refers to the processing and perception of signals arising from inside the body. Currently, there are two alternative conceptualizations of interoception: (1) an ‘inclusive’ view considering all bodily signals from inside the body as relevant for interoception, and (2) an ‘exclusive’ view, which is based on receptor types and neurophysiology, and, therefore, a focus on visceroception. These conceptualizations have different implications for the underlying neurophysiology and, therefore, the mechanisms behind embodiment. Thereafter, we discuss current models of interoception and provide definitions of the most common interoceptive terms, which include interoceptive accuracy, sensibility, sensitivity, awareness, and prediction error. We then present examples of interoceptive paradigms to assess different elements of interoception models. Typical interoceptive indicators include self-reports, behavioral measures, and neurophysiological indices. Finally, we discuss the link between interoceptive indicators and emotional experience and emotion regulation, consciousness, and decision-making. These findings illustrate the relevance of interoceptive indicators for embodiment. [less ▲]

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See detailL'indomptable vitalité de la mode
Roelens, Nathalie UL

in forum (2021)

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See detailThe Contribution of Microglia to Neuroinflammation in Parkinson's Disease.
Badanjak, Katja UL; Fixemer, Sonja UL; Smajic, Semra UL et al

in International journal of molecular sciences (2021), 22(9),

With the world's population ageing, the incidence of Parkinson's disease (PD) is on the rise. In recent years, inflammatory processes have emerged as prominent contributors to the pathology of PD. There ... [more ▼]

With the world's population ageing, the incidence of Parkinson's disease (PD) is on the rise. In recent years, inflammatory processes have emerged as prominent contributors to the pathology of PD. There is great evidence that microglia have a significant neuroprotective role, and that impaired and over activated microglial phenotypes are present in brains of PD patients. Thereby, PD progression is potentially driven by a vicious cycle between dying neurons and microglia through the instigation of oxidative stress, mitophagy and autophagy dysfunctions, a-synuclein accumulation, and pro-inflammatory cytokine release. Hence, investigating the involvement of microglia is of great importance for future research and treatment of PD. The purpose of this review is to highlight recent findings concerning the microglia-neuronal interplay in PD with a focus on human postmortem immunohistochemistry and single-cell studies, their relation to animal and iPSC-derived models, newly emerging technologies, and the resulting potential of new anti-inflammatory therapies for PD. [less ▲]

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See detailFunctional and Molecular Properties of DYT-SGCE Myoclonus-Dystonia Patient-Derived Striatal Medium Spiny Neurons.
Kutschenko, Anna; Staege, Selma; Grütz, Karen et al

in International journal of molecular sciences (2021), 22(7),

Myoclonus-dystonia (DYT-SGCE, formerly DYT11) is characterized by alcohol-sensitive, myoclonic-like appearance of fast dystonic movements. It is caused by mutations in the SGCE gene encoding ε-sarcoglycan ... [more ▼]

Myoclonus-dystonia (DYT-SGCE, formerly DYT11) is characterized by alcohol-sensitive, myoclonic-like appearance of fast dystonic movements. It is caused by mutations in the SGCE gene encoding ε-sarcoglycan leading to a dysfunction of this transmembrane protein, alterations in the cerebello-thalamic pathway and impaired striatal plasticity. To elucidate underlying pathogenic mechanisms, we investigated induced pluripotent stem cell (iPSC)-derived striatal medium spiny neurons (MSNs) from two myoclonus-dystonia patients carrying a heterozygous mutation in the SGCE gene (c.298T>G and c.304C>T with protein changes W100G and R102X) in comparison to two matched healthy control lines. Calcium imaging showed significantly elevated basal intracellular Ca(2+) content and lower frequency of spontaneous Ca(2+) signals in SGCE MSNs. Blocking of voltage-gated Ca(2+) channels by verapamil was less efficient in suppressing KCl-induced Ca(2+) peaks of SGCE MSNs. Ca(2+) amplitudes upon glycine and acetylcholine applications were increased in SGCE MSNs, but not after GABA or glutamate applications. Expression of voltage-gated Ca(2+) channels and most ionotropic receptor subunits was not altered. SGCE MSNs showed significantly reduced GABAergic synaptic density. Whole-cell patch-clamp recordings displayed elevated amplitudes of miniature postsynaptic currents and action potentials in SGCE MSNs. Our data contribute to a better understanding of the pathophysiology and the development of novel therapeutic strategies for myoclonus-dystonia. [less ▲]

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See detailProjected Inventory Level Policies for Lost Sales Inventory Systems: Asymptotic Optimality in Two Regimes
van Jaarsveld, Willem; Arts, Joachim UL

E-print/Working paper (2021)

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See detailAssessment of a textile portable exoskeleton for the upper limbs' flexion
Samper-Escudero, Jose Luis; Coloma Chacon, Sofia UL; Olivares Mendez, Miguel Angel UL et al

Scientific Conference (2021)

Flexible exoskeletons are lightweight robots that surround the user’s anatomy to assist or oppose motion. Their structure is made of light and flexible materials, like fabrics, so the forces created by ... [more ▼]

Flexible exoskeletons are lightweight robots that surround the user’s anatomy to assist or oppose motion. Their structure is made of light and flexible materials, like fabrics, so the forces created by the robot are directly transferred to the user’s musculoskeletal system. Exosuits are thus sensitive to the sliding of the actuation, textile perturbations and improper fitting to the user. LUXBIT is a cable-driven flexible exoskeleton that combines fabrics and sewing patterns to promote its anatomical adaption. The exoskeleton is intended for bimanual assistance of daily tasks and long-term usage. To this end, the system reduces the pressures applied to the user and the misalignment of the actuation by stacking textile patches. The patches enhance the functioning of the base garment and promote the transference of the assistance forces. Additionally, LUXBIT has a compact actuation with deformable components to prevent the user movements from being restricted. The exoskeleton is portable by using an enhanced textile backpack. This paper shows the exoskeleton’s benefits for trajectory and muscle activity during the flexion of the shoulder and the elbow. [less ▲]

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See detailMessage from the General Chairs
Botev, Jean UL; El-Ghazawi, Tarek; Stewart, Christopher

in Proceedings of the 2nd IEEE International Conference on Autonomic Computing and Self-Organizing Systems (ACSOS) (2021)

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See detailCollaboration between home and crèches: perspectives, experiences and expectations of educators in Luxembourg
Kirsch, Claudine UL; Aleksic, Gabrijela UL

Scientific Conference (2021)

Multiliteracies in early childhood education are promoted by researchers in multilingual education (García et al., 2017) and the European Commission. One way in which educators in crèches can develop ... [more ▼]

Multiliteracies in early childhood education are promoted by researchers in multilingual education (García et al., 2017) and the European Commission. One way in which educators in crèches can develop literacies in multiple languages is through collaboration with parents. Collaboration has been shown to positively influence educators, parents, and children. Educators, for instance, become aware of children’s funds of knowledge and draw on the learners’ resources and make their teaching more linguistically and culturally inclusive (Wells Rowe & Miller, 2016). While collaboration can be highly effective, the establishment of partnerships is difficult. Successful partnerships depend on several factors, among them the professionals’ beliefs, experiences, expectations, as well as space and time (Lengyel & Salem, 2016; Reynolds et al., 2017). Collaboration has been a focus of attention in Luxembourg since the introduction of multilingual education in formal and non-formal early childhood institutions. Since 2017 teachers in schools and educators in crèches are required to develop children’s skills in Luxembourgish, familiarise them with French, and value their home languages. Partnerships with parents is one pillar of this programme. A previous study has shown that educators are beginning to develop such partnerships (Kirsch 2019). The longitudinal project Collaboration with parents and Multiliteracy in early Childhood Education (COMPARE) uses a mixed-method approach to examine the multiliteracy practices as well as partnership building between parents and educators in crèches in Luxembourg. In this paper we present the perspectives of educators on partnership building and multiliteracy. The data stem from two online questionnaires completed by educators in 2020. We examine the practitioners’ perspectives on collaboration (Betz et al. 2017), modes and types of partnerships (e.g. Thiersch, 2006), types and frequency of collaborative activities in multiple languages (e.g. Hachfeld et al., 2016), and factors influencing collaboration (e.g. Reynolds et al., 2017). The data show that the declared practices are multilingual and that parents come to the crèche to do literacy activities in languages other than the main one(s) of the crèches. However, new language hierarchies are being developed. The findings demonstrate that educators and parents are actors in shaping new policies while also pointing to some arising inequalities. [less ▲]

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See detailLEARN Newsletter - Édition 2021
Georges, Carrie UL; Hoffmann, Danielle; Hornung, Caroline UL et al

Book published by LEARN (2021)

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