Last 7 days     Results 21-40 of 48.   1 2 3   Poster Presentation: Talking Borders. From Local Expertise to Global Exchange - Das Potential von Citizen Science für die GrenzforschungJaschik, Johanna Maria Poster (2021, May 06)Detailed reference viewed: 52 (0 UL) Small States and the ‘Corona crisis’Högenauer, Anna-Lena ; Sarapuu, Külli; Trimikliniotis, Nicosin Small States & Territories (2021), 4(1), All papers are available open access on the journal's website.Detailed reference viewed: 29 (3 UL) Le droit à la sauce piquante n°23 - Mai 2021Hiez, David ; Laurent, Rémiin Le droit à la sauce piquante (2021), 23Detailed reference viewed: 61 (2 UL) Identifying and targeting metabolic vulnerabilities of IDH mutant gliomasCano Galiano, Andrés Doctoral thesis (2021)Diffuse gliomas are a group of central nervous system (CNS) tumors with a poor patient prognosis. Within these diffuse gliomas, isocitrate dehydrogenase (IDH) mutation defines the different tumor subtypes ... [more ▼]Diffuse gliomas are a group of central nervous system (CNS) tumors with a poor patient prognosis. Within these diffuse gliomas, isocitrate dehydrogenase (IDH) mutation defines the different tumor subtypes and is considered to be an initiating event in gliomagenesis. IDH is a metabolic enzyme that in normal conditions mediates the conversion of isocitrate into α-ketoglutarate (α-KG), producing the reducing equivalent NADPH. IDH mutation (IDHm) leads to a neomorphic reaction where α-KG is consumed to generate the oncometabolite D-2-hydroxyglutarate (D-2HG), using NADPH as reducing agent. It has been reported that IDHm-dependent D-2HG synthesis has a direct impact on DNA and histone methylation, however the metabolic repercussions are not yet well defined. Due to the consumption of NADPH by IDHm reaction, some groups including us have hypothesized that IDHm cells may bear an imbalance of reducing equivalents, that may trigger a defective antioxidant defense. In the present study we made use of patient-derived cell lines and xenografts thereof as well as clinical samples in order to study the metabolic vulnerabilities of IDHm gliomas. In the first part of the thesis experimental data, we generated an integrative liquid chromatography-mass spectrometry (LCMS)-based proteomic-metabolomic characterization of IDHm metabolism. We made use of patients, cell lines and xenografts to address the direct effect of the mutation. We observed that IDHm gliomas have altered regulation of key processes in central carbon metabolism through glucose and glutamate processing as well as glutathione (GSH) metabolism and fatty acid production. In the second part of experimental data, we investigated the redox vulnerabilities of IDHm gliomas. Here we discovered that IDHm astrocytomas specifically upregulate cystathionine-γ-lyase (CSE) enabling them to synthesize GSH independently of NADPH. CSE is the only known enzyme capable of synthesizing cysteine. We found that genetic and chemical inhibition of CSE led to a decrease in cell viability upon cysteine restriction. Finally inhibition of CSE in vivo led to a delay in tumor growth rate. In conclusion, in the present PhD dissertation we expose a comprehensive study of the metabolic behavior of IDHm human gliomas, and we propose a novel therapeutic strategy that might improve patient prognosis, by inflicting oxidative damage to the tumor. [less ▲]Detailed reference viewed: 69 (3 UL) Higher education trajectories and social origin in Germany and the United States: A comparative sequence-analytical approachHaas, Christina Doctoral thesis (2021)Students’ higher education trajectories as holistic educational processes are an underresearched aspect, particularly in the German context. This cumulative thesis fills this gap by investigating ... [more ▼]Students’ higher education trajectories as holistic educational processes are an underresearched aspect, particularly in the German context. This cumulative thesis fills this gap by investigating students’ trajectories through bachelor’s degree courses in German and US higher education. In terms of methodology, it is based on a sequence-analytical approach using two student panel data sets (the German National Educational Panel Study (NEPS) and the US Beginning Postsecondary Students Longitudinal Study (BPS)) and comprises a literature review and three empirical research articles, each providing a different theoretical and conceptual angle. Higher education is a non-compulsory educational phase, implying students are granted more autonomy and more choice but also require more personal responsibility to plan a path through higher education. As such, it is assumed that parents’ cultural resources – defined here as higher education-specific knowledge – and economic resources shape students’ trajectories to enable them to proceed through their studies in a more continuous or linear way and prevent students from experiencing complex trajectories, such as delays, interruptions or detours. To begin with, the literature review, constructed as a narrative review with systematic elements, captured the state of research on higher education trajectories by reviewing peer-reviewed journal articles from a wide range of mainly higher education research journals. It revealed that this research area is rather heterogeneous and dominated by studies focusing on the United States. Research articles one and two employ similar research strategies – sequence analyses followed by cluster analyses. Stressing the relationship between parents’ resources and students’ trajectories, the first article concentrates exclusively on students in German research universities, whereas the second also considers students at universities of applied sciences. Overall, these studies reveal that the trajectories of students at the universities of applied sciences are more often linear, while the opposite applies to students at research universities and students of low social origin, pointing towards the hypothesised effect of parental resources. Furthermore, students of low social origin are more likely to follow a linear standard trajectory when studying at a university of applied sciences compared to at a research university. In the third paper, based on the premise that trajectories are systematically shaped by the institutional context of the higher education system, students’ trajectories in German and US higher education are compared, allowing to simultaneously a view on system-level characteristics and national idiosyncrasies. US higher education provides almost universal access, is very marketised and highly differentiated, thereby accommodating diverse demands and heterogeneous student groups. By contrast, German higher education, based on public funding and regulation, early ability tracking and low permeability, restricts access and provides an overall much less diversified study offering. Consequently, research article three revealed that students’ trajectories are overall less standardised in US higher education – but this differs greatly by higher education sector, whereas the trajectories of students in the (selective) research universities are overall more standardized. Furthermore, the social origin differences were quite pronounced in the United States, whereas the social origin effect was almost nonexistent for students in German higher education in this study (based on a different sequence-analytical approach). Remarkable, though, remains the finding that students’ trajectories are less linear at German research universities compared to the universities of applied sciences – even more so among students of low social origin – while US research universities facilitate linear trajectories. Overall, this dissertation provides an important contribution to the state of research on link between social origin, students’ trajectories and how this link is mediated by the institutional context of the respective higher education system. [less ▲]Detailed reference viewed: 36 (5 UL) Évaluation de la mémoire de travail : un outil de différenciation entre trouble du langage et différence du langage dans des contextes multilingues ?Wealer, Cyril ; Engel de Abreu, Pascale in ANAE: Approche Neuropsychologique des Apprentissages chez l'Enfant (2021), 33(171), Diagnostiquer les troubles du langage chez les enfants bilingues repré- sente un défi clinique en raison des similitudes dans le profil de compé- tence linguistique entre les enfants bilingues au ... [more ▼]Diagnostiquer les troubles du langage chez les enfants bilingues repré- sente un défi clinique en raison des similitudes dans le profil de compé- tence linguistique entre les enfants bilingues au développement typique et les enfants monolingues avec un trouble du langage. Les mesures de la mémoire de travail dépendent moins des connaissances accumulées que les tests de langage traditionnels et pourraient contribuer à différen- cier un trouble du langage d’une différence de langage liée aux expé- riences avec une langue. [less ▲]Detailed reference viewed: 20 (1 UL) Assessments of working memory: a tool for differentiating between language disorder and language difference in multilingual contexts?Wealer, Cyril ; Engel de Abreu, Pascale in ANAE: Approche Neuropsychologique des Apprentissages chez l'Enfant (2021), 33(171), 194-204Diagnosing language disorders in bilingual children represents a clini- cal challenge because of similarities in the language proficiency profile between typically developing bilingual children and ... [more ▼]Diagnosing language disorders in bilingual children represents a clini- cal challenge because of similarities in the language proficiency profile between typically developing bilingual children and monolingual chil- dren with a language disorder. Measures of working memory are less dependent on accumulated knowledge than traditional language tests and might help to differentiate a language disorder from a language dif- ference related to experiences with a language. [less ▲]Detailed reference viewed: 23 (3 UL) dolfiny: Convenience wrappers for DOLFINxZilian, Andreas ; Habera, Michal Scientific Conference (2021, March 23)With the increased flexibility of DOLFINx and its reduction to core functionality, the responsibility for even some basic components of computational analysis is shifted to the user. This presentation ... [more ▼]With the increased flexibility of DOLFINx and its reduction to core functionality, the responsibility for even some basic components of computational analysis is shifted to the user. This presentation provides an overview of the open-source package dolfiny, which provides end-user API interfaces to mesh/meshtags generation and processing, expression list handling, function interpolation and projection as well as the restriction of function spaces to parts of the computational domain. This functionality is consistently considered in interfaces to PETSc/SNES as nonlinear solver and SLEPc as eigensolver backend, both allowing the operation on block and nested operators. In addition, the package provides a convenient approach to incorporate time integration into the UFL formulation of the problem, which is exemplified for the generalised alpha method. The capability of dolfiny is demonstrated in a number of examples, ranging between finite strain structural analysis, plasticity and fluid-structure interaction. [less ▲]Detailed reference viewed: 56 (1 UL) A History of Pathé 9.5mm filmvan der Heijden, Tim Speeches/Talks (2021)Presentation about the history of Pathé 9.5mm film for students of the Lycée Technique des Arts et Métiers (LTAM) in Luxembourg. Invited lecture organized by the Centre national de l'audiovisuel (CNA ... [more ▼]Presentation about the history of Pathé 9.5mm film for students of the Lycée Technique des Arts et Métiers (LTAM) in Luxembourg. Invited lecture organized by the Centre national de l'audiovisuel (CNA) Luxembourg, Dudelange, on 17 March 2021. [less ▲]Detailed reference viewed: 34 (0 UL) Bewertungshilfe zur Unterrichtseinheit #keinfilterKrämer, Charlotte ; Kang, Liana; Bissen, Manuelin Programme for Innovative Teaching and Testing (PITT): #digitallife (2021)Detailed reference viewed: 30 (3 UL) Backscatter-Assisted Data Offloading inOFDMA-based Wireless Powered Mobile EdgeComputing for IoT NetworksNguyen, Xuan Phu; Tran Dinh, Hieu ; Onireti, ‪Oluwakayode et alin IEEE Internet of Things Journal (2021)Mobile edge computing (MEC) has emerged as a prominent technology to overcome sudden demands on computation-intensive applications of the Internet of Things (IoT) with finite processing capabilities ... [more ▼]Mobile edge computing (MEC) has emerged as a prominent technology to overcome sudden demands on computation-intensive applications of the Internet of Things (IoT) with finite processing capabilities. Nevertheless, the limited energy resources also seriously hinders IoT devices from offloading tasks that consume high power in active RF communications. Despite the development of energy harvesting (EH) techniques, the harvested energy from surrounding environments could be inadequate for power-hungry tasks. Fortunately, Backscatter communications (Backcom) is an intriguing technology to narrow the gap between the power needed for communication and harvested power. Motivated by these considerations, this paper investigates a backscatter-assisted data offloading in OFDMA-based wireless-powered (WP) MEC for IoT systems. Specifically, we aim at maximizing the sum computation rate by jointly optimizing the transmit power at the gateway (GW), backscatter coefficient, time-splitting (TS) ratio, and binary decision-making matrices. This problem is challenging to solve due to its non-convexity. To find solutions, we first simplify the problem by determining the optimal values of transmit power of the GW and backscatter coefficient. Then, the original problem is decomposed into two sub-problems, namely, TS ratio optimization with given offloading decision matrices and offloading decision optimization with given TS ratio. Especially, a closedform expression for the TS ratio is obtained which greatly enhances the CPU execution time. Based on the solutions of the two sub-problems, an efficient algorithm, termed the fast-efficient algorithm (FEA), is proposed by leveraging the block coordinate descent method. Then, it is compared with exhaustive search (ES), bisection-based algorithm (BA), edge computing (EC), and local computing (LC) used as reference methods. As a result, the FEA is the best solution which results in a near-globally-optimal solution at a much lower complexity as compared to benchmark schemes. For instance, the CPU execution time of FEA is about 0.029 second in a 50-user network, which is tailored for ultralow latency applications of IoT networks. [less ▲]Detailed reference viewed: 35 (0 UL) Children, Young People, and Borders: A Multidisciplinary OutlookVenken, Machteld ; Kaisto, Virpi; Brambilla, Chiarain Journal of Borderlands Studies (2021), 36(2), Detailed reference viewed: 62 (0 UL) A rigged model of the breast for preoperative surgical planningMazier, Arnaud ; Ribes, Sophie; Testylier, Romain et alE-print/Working paper (2021)In breast surgical practice, various scans and medical examinations are performed before surgery. This includes identifying landmarks defining the operating procedure. In most cases, the position of the ... [more ▼]In breast surgical practice, various scans and medical examinations are performed before surgery. This includes identifying landmarks defining the operating procedure. In most cases, the position of the patient during the scan is vastly different from the one encountered during the operation. We address the challenge of mapping preoperative information to the operating field, with the following constraints: registration has to be done in less than 10 seconds to be compatible with a clinical workflow; the cost of the device must be small and we assume data scarcity, i.e. that our database has twenty scans of patients at most. We build anatomical complexity through a skinning model comprised of scalable bones (to account for pose and morphological variations) and deformable organs (blendshapes, to account for anatomical variations). Similar to animation rigs used in computer graphics, and in contrast to statistical approaches, we manually design a model with some desirable properties, using a reduced number of well-chosen degrees of freedom. Meaningful constraints can be applied to the registration depending on the context, and the trade-off between precision and complexity can be optimized. The result is a surface mesh of the patient obtained in less than 1 minute (scan and reconstruction included) and a registration method that converges within a few seconds (3 maximum), reaching a mean absolute squared error of 2.3 mm for mesh registration and 8.0 mm for anatomical landmarks. The registered model is used to transfer surgical reference patterns on any patient in any position. [less ▲]Detailed reference viewed: 32 (2 UL) Leverage crowdsourced datasets for travel demand analysisVitello, Piergiorgio Poster (2021)Detailed reference viewed: 36 (4 UL) Art of Cultural Diplomacy as Aesthetic in the Academic Research -Art/Theatre InterfaceNonoa, Koku Gnatuloma in Brown, Ashley; Carbon, François; Chambers, Bill (Eds.) et al TAD’ Liber Memorialis e-book (2021)Cultural diplomacy "refers to the exchange of ideas, information, art, and other aspects of culture among nations and their peoples to foster mutual understanding." (Cummings, 2003, p. 1). However, how ... [more ▼]Cultural diplomacy "refers to the exchange of ideas, information, art, and other aspects of culture among nations and their peoples to foster mutual understanding." (Cummings, 2003, p. 1). However, how can we interpret cultural diplomacy and act upon it in and outside academia? How can universities harness the potentiality of cultural diplomacy to transform societies? These are among others the leading questions discussed in the international panel on "the art of cultural diplomacy: cultural diplomacy in and outside academia" linked to international students as 'students as global citizens'. This discussion panel took place in 2017 May, the 26 in the framework of the 4th Transatlantic Dialogue titled "Creating Human Bonds Through Cultural Diplomacy." The panel gathered and focused on diverse engagements and activities of international students and student a airs professionals from all continents of the world as potential agents of the art of cultural diplomacy in and outside academia. Our analysis builds on these questions and the objectives of this panel. It discusses from a combined perspective of an academic research-art interface the art of cultural diplomacy as an aesthetic and a means of intercultural awareness and cultural interactions and reciprocal knowledge transfer between academia and the society or the general public. [less ▲]Detailed reference viewed: 57 (0 UL) Technostalgie du présent: des technologies de la mémoire à une mémoire des technologiesvan der Heijden, Tim in Fantin, Emmanuelle; Fevry, Sébastien; Niemeyer, Katharina (Eds.) Nostalgies contemporaines: Médias, cultures et technologies (2021)French translation of the article "Technostalgia of the present: from technologies of memory to a memory of technologies" (2015): https://necsus-ejms.org/technostalgia-present-technologies-memory-memory ... [more ▼]French translation of the article "Technostalgia of the present: from technologies of memory to a memory of technologies" (2015): https://necsus-ejms.org/technostalgia-present-technologies-memory-memory-technologies/. [less ▲]Detailed reference viewed: 18 (0 UL) The Weyl problem for unbounded convex domains in $\HH^3$Schlenker, Jean-Marc E-print/Working paper (2021)Let $K\subset \HH^3$ be a convex subset in $\HH^3$ with smooth, strictly convex boundary. The induced metric on $\partial K$ then has curvature $K>-1$. It was proved by Alexandrov that if $K$ is bounded ... [more ▼]Let $K\subset \HH^3$ be a convex subset in $\HH^3$ with smooth, strictly convex boundary. The induced metric on $\partial K$ then has curvature $K>-1$. It was proved by Alexandrov that if $K$ is bounded, then it is uniquely determined by the induced metric on the boundary, and any smooth metric with curvature $K>-1$ can be obtained. We propose here an extension of the existence part of this result to unbounded convex domains in $\HH^3$. The induced metric on $\partial K$ is then clearly not sufficient to determine $K$. However one can consider a richer data on the boundary including the ideal boundary of $K$. Specifically, we consider the data composed of the conformal structure on the boundary of $K$ in the Poincar\'e model of $\HH^3$, together with the induced metric on $\partial K$. We show that a wide range of "reasonable" data of this type, satisfying mild curvature conditions, can be realized on the boundary of a convex subset in $\HH^3$. We do not consider here the uniqueness of a convex subset with given boundary data. [less ▲]Detailed reference viewed: 17 (0 UL) Innovation in Malmö after the Öresund BridgeEjermo, Olof; Hussinger, Katrin ; Kalash, Basheer et alE-print/Working paper (2021)Detailed reference viewed: 21 (4 UL) Das Schöne und das Monströse bei Eichendorff und ShelleyKohns, Oliver in Mitteilungen des Deutschen Germanistenverbandes (2021), 68(2), 192-208Detailed reference viewed: 20 (0 UL) Testing associations between global and specific levels of student academic motivation and engagement in the classroomDierendonck, Christophe ; Tóth-Király, István; Morin, Alexandre et alin The Journal of Experimental Education (2021)Detailed reference viewed: 27 (0 UL)   1 2 3