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See detailA new synuclein-transgenic mouse model for early Parkinson's reveals molecular features of preclinical disease
Hendrickx, Diana M.; Garcia, Pierre; Ashrafi, Amer et al

in Molecular Neurobiology (in press)

Understanding Parkinson’s disease (PD) in particular in its earliest phases, is important for diagnosis and treatment. However, human brain samples are collected post- mortem, reflecting mainly end stage ... [more ▼]

Understanding Parkinson’s disease (PD) in particular in its earliest phases, is important for diagnosis and treatment. However, human brain samples are collected post- mortem, reflecting mainly end stage disease. Because brain samples of mouse models can be collected at any stage of the disease process, they are useful to investigate PD progression. Here, we compare ventral midbrain transcriptomics profiles from α- synuclein transgenic mice with a progressive, early PD-like striatal neurodegeneration across different ages using pathway, gene set and network analysis methods. Our study uncovers statistically significant altered genes across ages and between genotypes with known, suspected, or unknown function in PD pathogenesis and key pathways associated with disease progression. Among those are genotype-dependent alterations associated with synaptic plasticity, neurotransmission, as well as mitochondria-related genes and dysregulation of lipid metabolism. Age-dependent changes were among others observed in neuronal and synaptic activity, calcium homeostasis, and membrane receptor signaling pathways, many of which linked to G- protein coupled receptors. Most importantly, most changes occurred before neurodegeneration was detected in this model, which points to a sequence of gene expression events that may be relevant for disease initiation and progression. It is tempting to speculate that molecular changes similar to those changes observed in our model happen in midbrain dopaminergic neurons before they start to degenerate. In other words, we believe we have uncovered molecular changes that accompany the progression from preclinical to early PD. [less ▲]

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See detailDu mode bureaucratique vers l’agilité organisationnelle : le rôle de la communauté de pratique pilotée dans un établissement public
Obringer, Lisa Désirée UL; Geraudel, Mickaël UL; Benedic, Michael

in Projectique (in press)

Les établissements publics ont besoin de faire preuve d’agilité organisationnelle pour être performants et répondre aux nouveaux enjeux sociétaux. Cependant, ce besoin d’agilité est freiné par la logique ... [more ▼]

Les établissements publics ont besoin de faire preuve d’agilité organisationnelle pour être performants et répondre aux nouveaux enjeux sociétaux. Cependant, ce besoin d’agilité est freiné par la logique bureaucratique qui sous-tend le fonctionnement-même de ces établissements. Résoudre cette tension paradoxale entre bureaucratie et agilité organisationnelle requiert de mettre en œuvre le processus d’acceptation et de management de la tension paradoxale. Pour ce faire, la communauté de pratique pilotée offre un cadre d’analyse favorisant cette acceptation et donc le changement organisationnel souhaité. Ainsi, nous montrons, au travers d’une recherche action, comment la communauté de pratiques pilotée favorise le changement organisationnel au sein d’un établissement public luxembourgeois en facilitant sa transition d’une logique bureaucratique vers une logique d’agilité organisationnelle. Les implications sont doubles. Premièrement, nous montrons comment manager la tension entre bureaucratie et agilité au sein d’un établissement public. Deuxièmement, nous mettons en lumière le rôle de la communauté de pratique pilotée comme vecteur de changement organisationnel d’un établissement public. [less ▲]

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See detailNoradrenergic activation induced by yohimbine decreases interoceptive accuracy in healthy individuals with childhood adversity
Schulz, André UL; Deuter, Christian E.; Breden, Ion-Hideo et al

in Development and Psychopathology (in press)

Acute stress affects interoception, but it remains unclear if this is due to activation of the sympatho-adreno-medullary (SAM) or hypothalamicpituitary-adrenocortical axis. This study aimed to investigate ... [more ▼]

Acute stress affects interoception, but it remains unclear if this is due to activation of the sympatho-adreno-medullary (SAM) or hypothalamicpituitary-adrenocortical axis. This study aimed to investigate the effect of SAM axis activation on interoceptive accuracy (IAcc). Central alpha2-adrenergic receptors represent a negative feedback mechanism of the SAM axis. Major depressive disorder and adverse childhood experiences (ACE) are associated with alterations in the biological stress systems, including central alpha2-adrenergic receptors. Here, healthy individuals with and without ACE as well as depressive patients with and without ACE (n=114; all without antidepressant medication) were tested after yohimbine (alpha2-adrenergic antagonist) and placebo. We assessed IAcc and sensibility in a heartbeat counting task. Increases in systolic and diastolic blood pressure after yohimbine confirmed successful SAM axis activation. IAcc decreased after yohimbine only in the healthy group with ACE, but remained unchanged in all other groups (‘group’ × ‘drug’ interaction). This effect may be due to selective up-regulation of alpha2-adrenergic receptors after childhood trauma, which reduces capacity for attention focus on heartbeats. The sympathetic neural pathway including alpha2-adrenergic circuitries may be essential for mediating interoceptive signal transmission. Suppressed processing of physical sensations in stressful situations may represent an adaptive response in healthy individuals who experienced ACE. [less ▲]

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See detailGene selection for optimal prediction of cell position in tissues from single-cell transcriptomics
Tanevski, Jovan; Nguyen, Thin; Truong, Buu et al

in Life Science Alliance (in press)

Single-cell RNA-seq (scRNAseq) technologies are rapidly evolving. While very informative, in standard scRNAseq experiments the spatial organization of the cells in the tissue of origin is lost. Conversely ... [more ▼]

Single-cell RNA-seq (scRNAseq) technologies are rapidly evolving. While very informative, in standard scRNAseq experiments the spatial organization of the cells in the tissue of origin is lost. Conversely, spatial RNA-seq technologies designed to maintain cell localization have limited throughput and gene coverage. Mapping scRNAseq to genes with spatial information increases coverage while providing spatial location. However, methods to perform such mapping have not yet been benchmarked. To fill this gap, we organized the DREAM Single-Cell Transcriptomics challenge focused on the spatial reconstruction of cells from the Drosophila embryo from scRNAseq data, leveraging as silver standard, genes with in situ hybridization data from the Berkeley Drosophila Transcription Network Project reference atlas. The 34 participating teams used diverse algorithms for gene selection and location prediction, while being able to correctly localize clusters of cells. Selection of predictor genes was essential for this task. Predictor genes showed a relatively high expression entropy, high spatial clustering and included prominent developmental genes such as gap and pair-rule genes and tissue markers. Application of the Top-10 methods to a zebrafish embryo dataset yielded similar performance and statistical properties of the selected genes than in the Drosophila data. This suggests that methods developed in this challenge are able to extract generalizable properties of genes that are useful to accurately reconstruct the spatial arrangement of cells in tissues. [less ▲]

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See detailLa technologie blockchain – et les tendances de la décorporéisation en droit et culture
Becker, Katrin UL

in Pistes. Revue de philosophie contemporaine. Éthique, politique, philosophie des techniques (in press), 1

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See detailIngeborg Bachmanns Simultan und die Frage der Rechtsbindung in Zeiten von Multilingualität und Transkulturalität
Becker, Katrin UL

in Walter, Tonio; Schramm, Edward (Eds.) Dichtung und Wahrheit - und Recht (in press)

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See detailHumanities als Rekonstrukteure des Rechts
Becker, Katrin UL

in the Ends of the Humanities (in press)

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See detailEfficient Preamble Detection and Time-of-Arrival Estimation for Single-Tone Frequency Hopping Random Access in NB-IoT
Chougrani, Houcine UL; Kisseleff, Steven UL; Chatzinotas, Symeon UL

in IEEE Internet of Things Journal (in press)

The narrowband internet of things (NB-IoT) standard is a new cellular wireless technology, which has been introduced by the 3rd Generation Partnership Project (3GPP) with the goal to connect massive low ... [more ▼]

The narrowband internet of things (NB-IoT) standard is a new cellular wireless technology, which has been introduced by the 3rd Generation Partnership Project (3GPP) with the goal to connect massive low-cost, low-complexity and long-life IoT devices with extended coverage. In order to improve power efficiency, 3GPP proposed a new Random Access (RA) waveform for NB-IoT based on a single-tone frequencyhopping scheme. RA handles the first connection between user equipments (UEs) and the base station (BS). Through this, UEs can be identified and synchronized with the BS. In this context, receiver methods for the detection of the new waveform should satisfy the requirements on the successful user detection as well as the timing synchronization accuracy. This is not a trivial task, especially in the presence of radio impairments like carrier frequency offset (CFO) which constitutes one of the main radio impairments besides the noise. In order to tackle this problem, we propose a new receiver method for NB-IoT Physical Random Access Channel (NPRACH). The method is designed to eliminate perfectly the CFO without any additional computational complexity and supports all NPRACH preamble formats. The associated performance has been evaluated under 3GPP conditions. We observe a very high performance compared both to 3GPP requirements and to the existing state-of-the-art methods in terms of detection accuracy and complexity. [less ▲]

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See detailDiscrete-Phase Sequence Design with Stopband and PSL Constraints for Cognitive Radar
Alaeekerahroodi, Mohammad UL; Kumar, Sumit UL; Mysore Rama Rao, Bhavani Shankar UL et al

in Proceedings of EuRAD 2020 (in press)

We present the design of discrete-phase sequences considering simultaneously the peak sidelobe level (PSL) and avoiding reserved frequency bands which are occupied by narrowband interferers or ... [more ▼]

We present the design of discrete-phase sequences considering simultaneously the peak sidelobe level (PSL) and avoiding reserved frequency bands which are occupied by narrowband interferers or communications. We use the coordinate descent framework and propose an algorithm to design discrete-phase sequences with spectral power suppressed in arbitrary bands and with low auto-correlation sidelobes in terms of PSL. Our proposed algorithm exploits fast Fourier transform and is, therefore, computationally efficient. The over-the-air experiments using implementation on software-defined radio show reasonable agreement with numerical simulations and feasibility for field-deployment [less ▲]

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See detailA Formal Framework of Software Product Line Analyses
Castro, Thiago; Teixeira, Leopoldo; Alves, Vander et al

in ACM Transactions on Software Engineering and Methodology (in press)

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See detailMachine Learning-Enabled Joint Antenna Selection and Precoding Design: From Offline Complexity to Online Performance
Vu, Thang Xuan UL; Chatzinotas, Symeon UL; Nguyen, van Dinh UL et al

in IEEE Transactions on Wireless Communications (in press)

We investigate the performance of multi-user multiple-antenna downlink systems in which a base station (BS) serves multiple users via a shared wireless medium. In order to fully exploit the spatial ... [more ▼]

We investigate the performance of multi-user multiple-antenna downlink systems in which a base station (BS) serves multiple users via a shared wireless medium. In order to fully exploit the spatial diversity while minimizing the passive energy consumed by radio frequency (RF) components, the BS is equipped with M RF chains and N antennas, where M < N. Upon receiving pilot sequences to obtain the channel state information (CSI), the BS determines the best subset of M antennas for serving the users. We propose a joint antenna selection and precoding design (JASPD) algorithm to maximize the system sum rate subject to a transmit power constraint and quality of service (QoS) requirements. The JASPD overcomes the non-convexity of the formulated problem via a doubly iterative algorithm, in which an inner loop successively optimizes the precoding vectors, followed by an outer loop that tries all valid antenna subsets. Although approaching the (near) global optimality, the JASPD suffers from a combinatorial complexity, which may limit its application in real-time network operations. To overcome this limitation, we propose a learning-based antenna selection and precoding design algorithm (L-ASPA), which employs a deep neural network (DNN) to establish underlaying relations between the key system parameters and the selected antennas. The proposed L-ASPD is robust against the number of users and their locations, BS's transmit power, as well as the small-scale channel fading. With a well-trained learning model, it is shown that the L-ASPD significantly outperforms baseline schemes based on the block diagonalization and a learning-assisted solution for broadcasting systems and achieves higher effective sum rate than that of the JASPA under limited processing time. In addition, we observed that the proposed L-ASPD can reduce the computation complexity by 95% while retaining more than 95% of the optimal performance. [less ▲]

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See detailThe categorified Grothendiek-Riemann-Roch Theorem
Scherotzke, Sarah UL; Sibilla, Nicolo; Safronov, Pavel et al

in Compositio Mathematica (in press)

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See detailFamilies and family values in society and culture
Albert, Isabelle UL; Emirhafizovic, Mirza; Shpigelman, Carmit-Noa et al

Book published by Information Age Publishing (in press)

This book which has been created in the framework of the EU-funded COST Action INTERFASOL brings together researchers from 22 INTERFASOL countries, who frame intergenerational family solidarity in the ... [more ▼]

This book which has been created in the framework of the EU-funded COST Action INTERFASOL brings together researchers from 22 INTERFASOL countries, who frame intergenerational family solidarity in the specific historical, cultural, social and economic context of their own country. Integrating different perspectives from social and political sciences, economics, communication, health and psychology, the book offers country-specific knowledge and new insights into family relations, family values and family policies across Europe. The volume is the product of a unique endeavor of researchers across Europe to provide up-to-date first-hand country-specific knowledge on family and intergenerational relations and will serve as a base for both country-specific as well as cross-cultural studies. [less ▲]

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See detailBenefits, Motivations, and Challenges of International Collaborative Research: A Sociology of Science Case Study
Dusdal, Jennifer UL; Powell, Justin J W UL

in Science and Public Policy (in press)

Contemporary science is marked by expanding, diverse forms of teamwork. Collaboration across organizational and cultural boundaries extends the possibilities of discovery. International collaborative ... [more ▼]

Contemporary science is marked by expanding, diverse forms of teamwork. Collaboration across organizational and cultural boundaries extends the possibilities of discovery. International collaborative research projects can provide findings beyond what one team could achieve alone. Motivated to grow their scientific network and maintain existing relationships, researchers increasingly collaborate, despite often unrecognized costs, since such projects are challenging to manage and carry out. Rarely studied in-depth and longitudinally, researcher perspectives are crucial to better understand the dynamics of durable collaboration networks. Thus, this retrospective, longitudinal case study of a sociology of science project applies the novel method of autoethnography to examine teamwork benefits, motivations, and challenges. Key challenges found include spatial distance and differences of culture, language, and career stage. This study, spanning North America, Europe, the Middle East, and East Asia, focused on collaborators’ characteristics and evolving perceptions of team dynamics over a decade. [less ▲]

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See detailReligiosity predicts unreasonable coping with COVID-19
Kranz, Dirk; Niepel, Christoph UL; Botes, E'louise UL et al

in Psychology of Religion and Spirituality (in press)

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See detailIllusory gender-equality paradox, math self-concept, and frame-of-reference effects: New integrative explanations for multiple paradoxes
Marsh, Herbert W.; Parker, Philip D.; Guo, Jiesi et al

in Journal of Personality and Social Psychology (in press)

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See detailA hyperbolic proof of Pascal's Theorem
acosta, Miguel; Schlenker, Jean-Marc UL

in Mathematical Intelligencer (in press)

We provide a simple proof of Pascal's Theorem on cyclic hexagons, as well as a generalization by Möbius, using hyperbolic geometry.

Detailed reference viewed: 40 (0 UL)
See detailIntergenerational Family Solidarity across Europe
Albert, Isabelle UL; Emirhafizovic, Mirza; Shpigelman, Carmit-Noa et al

in Albert, Isabelle; Emirhafizovic, Mirza; Shpigelman, Carmit-Noa (Eds.) et al Families and family values in society and culture (in press)

The global trend of ageing populations is particularly pronounced in Europe. In the wake of increased life expectancies, intergenerational family relationships have become more and more important over the ... [more ▼]

The global trend of ageing populations is particularly pronounced in Europe. In the wake of increased life expectancies, intergenerational family relationships have become more and more important over the last few decades. The COST Action INTERFASOL started from the claim that in light of these developments societies need to develop mechanisms, programs and policies that will support solidarity between the young, middle and older generations. Although considerable research activities in the field of intergenerational relations have been carried out in the last years, a lack in coordination and integration of different studies from different settings was noted. Bringing together research from different countries to coordinate studies and synthesize results is not an easy endeavor but it has turned out as a fruitful venture: INTERFASOL has been successful in bringing together researchers from 28 different countries meeting regularly, discussing current issues and not least producing a large number of publications and research proposals. One outcome of the COST Action is this volume which has the aim to become a reference for all those who are interested in intergenerational relations in Europe: the chapters will provide the basis and a starting point for further research. [less ▲]

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See detailFamily in a multicultural context: Country report for Luxembourg
Albert, Isabelle UL; Heinz, Andreas UL

in Albert, Isabelle; Emirhafizovic, Mirza; Shpigelman, Carmit-Noa (Eds.) et al Families and family values in society and culture (in press)

The Grand Duchy of Luxembourg is a small country in the heart of Europe, neighbouring France, Germany and Belgium, counting on 1 January of 2019 613.894 inhabitants on a total area of 2,586 km² ... [more ▼]

The Grand Duchy of Luxembourg is a small country in the heart of Europe, neighbouring France, Germany and Belgium, counting on 1 January of 2019 613.894 inhabitants on a total area of 2,586 km². Immigration and cultural diversity have become one of the key features in the last years as the share of foreigners has constantly increased to now 47% of the population (Statec, 2019). Recent migrants live on the territory along with ageing migrants who are now close to retirement, as well as earlier generations of migrants. Luxembourg can therefore today be characterized as super-diverse (Vertovec, 2007) and is seen as a sample case for European integration, certainly of high interest also regarding intergenerational family solidarity in the light of migration. We will outline the complex demographic picture in the following sections, focusing on socio-economic aspects as well as social policy issues and have then a closer look on intergenerational family solidarity and future areas of research. [less ▲]