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See detailLexicometric and Informational Measures in Political and Literary Corpora
Armaselu, Florentina UL

in Studii şi Cercetări Lingvistice (2021), 2(LXXI – 2020, iulie–decembrie (July - December)), 163-178

The paper presents a method for corpus-based informational analysis, using an open source platform for lexicometric processing and a spreadsheet application. This type of study may serve in illustrating ... [more ▼]

The paper presents a method for corpus-based informational analysis, using an open source platform for lexicometric processing and a spreadsheet application. This type of study may serve in illustrating the factors that influence informational measures such as entropy, energy and informativity, and in detecting certain structural or stylistic particularities of the analysed corpora. [less ▲]

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See detailRevealing defect-induced spin disorder in nanocrystalline Ni
Bersweiler, Mathias UL; Michels, Andreas UL; Sinaga, Evelyn Pratami UL et al

in Physical Review Materials (2021), 5(4), 044409

Detailed reference viewed: 24 (4 UL)
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See detailLoss of function variants in the KCNQ5 gene are associated with genetic generalized epilepsies
Krueger, Johanna; Schubert, Julian; Kegele, Josua et al

E-print/Working paper (2021)

Objective: De novo missense variants in KCNQ5, encoding the voltage gated K+ channel KV7.5, have been described as a cause of developmental and epileptic encephalopathy (DEE) or intellectual disability ... [more ▼]

Objective: De novo missense variants in KCNQ5, encoding the voltage gated K+ channel KV7.5, have been described as a cause of developmental and epileptic encephalopathy (DEE) or intellectual disability (ID). We set out to identify disease-related KCNQ5 variants in genetic generalized epilepsy (GGE) and their underlying mechanisms. Methods: 1292 families with GGE were studied by next-generation sequencing. Whole-cell patch-clamp recordings, biotinylation and phospholipid overlay assays were performed in mammalian cells combined with docking and homology modeling. Results: We identified three deleterious heterozygous missense variants, one truncation and one splice site alteration in five independent families with GGE with predominant absence seizures, two variants were also associated with mild to moderate ID. All three missense variants displayed a strongly decreased current density indicating a loss-of-function (LOF). When mutant channels were co-expressed with wild-type (WT) KV7.5 or KV7.5 and KV7.3 channels, three variants also revealed a significant dominant-negative effect on WT channels. Other gating parameters were unchanged. Biotinylation assays indicated a normal surface expression of the variants. The p.Arg359Cys variant altered PI(4,5)P2-interaction, presumably in the non-conducting preopen-closed state. Interpretation: Our study indicates that specific deleterious KCNQ5 variants are associated with GGE, partially combined with mild to moderate ID. The disease mechanism is a LOF partially with dominant-negative effects through functional, rather than trafficking deficits. LOF of KV7.5 channels will reduce the M-current, likely resulting in increased excitability of KV7.5-expressing neurons. Further studies on a network level are necessary to understand which circuits are affected and how the variants induce generalized seizures. [less ▲]

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See detailAddressing seeming paradoxes by embracing them: small state theory and the integration of migrants
Kolnberger, Thomas UL; Koff, Harlan UL

in Comparative Migration Studies (2021), 9

This article examines the integration of migrants in Luxembourg within the framework of small state theory. Within the comparative scholarship on migration, small states are often presented as “success ... [more ▼]

This article examines the integration of migrants in Luxembourg within the framework of small state theory. Within the comparative scholarship on migration, small states are often presented as “success stories.” This research questions this assumption and empirical data presented here indicates that many contradictions exist within Luxembourg’s migrant integration model. The country’s “success” in fact does not reflect the levels of integration of migrants nationally as significant inequalities are present in Luxembourg. However, the analysis of Luxembourg presented here illustrates how small states have coherently embraced many paradoxes that are inherent to integration strategies throughout Europe with the goal of promoting peaceful coexistence. [less ▲]

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See detailProjects, plans and publications
Aleksic, Gabrijela UL

Presentation (2021, April 20)

Presenting the TRANSLA project among others

Detailed reference viewed: 28 (0 UL)
See detailLe scritture dei centri monastici (VIII-XIV secolo)
Salemme, Timothy UL

Presentation (2021, April 20)

Detailed reference viewed: 84 (0 UL)
See detailStudying transnational events through web archives
Schafer, Valerie UL

Scientific Conference (2021, April 20)

This short presentation was a mid-term feedback on the collective work of WG2 that I lead within the WARCnet project. I especially underlined the research we conducted through an internal datathon we ... [more ▼]

This short presentation was a mid-term feedback on the collective work of WG2 that I lead within the WARCnet project. I especially underlined the research we conducted through an internal datathon we organised in January 2021 and which used seed lists, derived data and metadata. [less ▲]

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See detailGesundheit von Schülerinnen und Schülern in Luxemburg - Bericht zur luxemburgischen HBSC-Befragung 2018
Heinz, Andreas UL; Kern, Matthias Robert

Report (2021)

Der Bericht gibt Auskunft über Gesundheit und Wohlbefinden der Schüler im Jahr 2018 in ihrem sozialen Kontext. Darüber hinaus informiert er, wie sich die entsprechenden Indikatoren von 2006—2018 in ... [more ▼]

Der Bericht gibt Auskunft über Gesundheit und Wohlbefinden der Schüler im Jahr 2018 in ihrem sozialen Kontext. Darüber hinaus informiert er, wie sich die entsprechenden Indikatoren von 2006—2018 in Luxemburg entwickelt haben. Verbesserungen gab es vor allem beim Gesundheitsverhalten — die Schüler rauchen und trinken weniger, sie putzen sich häufiger die Zähne und essen mehr Obst und Gemüse. Verschlechterungen betreffen die mentale Gesundheit: Die Schüler haben häufiger psychosomatische Beschwerden und sie fühlen sich häufiger von der Schularbeit gestresst. Des Weiteren sind die Schüler häufiger übergewichtig und sie sind seltener körperlich aktiv. Der Bericht zeigt auch, dass Gesundheitsrisiken mit soziodemografischen Merkmalen zusammenhängen, wie u. a. dem Geschlecht, dem Alter, dem Wohlstand und dem Migrationshintergrund. So verhalten sich Mädchen zwar häufig gesundheitsbewusster als Jungen, aber dennoch schätzen sie ihren Gesundheitszustand schlechter ein und sie haben mehr Stress und sie sind häufiger von multiplen psychosomatischen Beschwerden betroffen. Aus Clusteranalysen geht hervor, dass es typische Konstellationen von Gesundheitsverhaltensweisen gibt, die zudem mit soziodemografischen Merkmalen sowie Übergewicht, Stress und der Lebenszufriedenheit zusammenhängen. [less ▲]

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See detailMultilingual education in early years in Luxembourg: a paradigm shift?
Kirsch, Claudine UL; Aleksic, Gabrijela UL

in International Journal of Multilingualism (2021)

This paper is based in Luxembourg where a multilingual programme has been implemented in early childhood education in 2017. The research project examines the language use in daily communication and ... [more ▼]

This paper is based in Luxembourg where a multilingual programme has been implemented in early childhood education in 2017. The research project examines the language use in daily communication and literacy activities of educators and parents in day care centres, as reported by educators in two online-questionnaires. The findings show that the educators and parents use multiple languages when communicating, singing and reading with children in the centres. In addition to French and Luxembourgish which dominate, they use five other languages. Their reported multilingual practice reflects their beliefs that speaking and reading in several languages promotes language learning. However, while the programme is multilingual, a range of home languages are marginalised. The educators produce a language hierarchy in the centres which the parents reproduce. While collaboration with parents can be effective in bringing home languages into day care centres, educators need to be aware of language hierarchies and ideologies. [less ▲]

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See detailUltra-rare constrained missense variants in the epilepsies: Shared and specific enrichment patterns in neuronal gene-sets 2021.04.18.440264
Koko, Mahmoud; Krause, Roland UL; Sander, Thomas et al

E-print/Working paper (2021)

Background: Burden analysis in epilepsy has shown an excess of deleterious ultra-rare variants (URVs) in few gene-sets, such as known epilepsy genes, constrained genes, ion channel or GABAA receptor genes ... [more ▼]

Background: Burden analysis in epilepsy has shown an excess of deleterious ultra-rare variants (URVs) in few gene-sets, such as known epilepsy genes, constrained genes, ion channel or GABAA receptor genes. We set out to investigate the burden of URVs in a comprehensive range of gene-sets presumed to be implicated in epileptogenesis. Methods: We investigated several constraint and conservation-based strategies to study whole exome sequencing data from European individuals with developmental and epileptic encephalopathies (DEE, n = 1,003), genetic generalized epilepsy (GGE, n = 3,064), and non-acquired focal epilepsy (NAFE, n = 3,522), collected by the Epi25 Collaborative, compared to 3,962 ancestry-matched controls. The burden of 12 URVs types in 92 gene-sets was compared between epilepsy cases (DDE, GGE, NAFE) and controls using logistic regression analysis. Results: Burden analysis of brain-expressed genes revealed an excess of different URVs types in all three epilepsy categories which was largest for constrained missense variants. The URVs burden was prominent in neuron-specific, synaptic and developmental genes as well as genes encoding ion channels and receptors, and it was generally higher for DEE and GGE compared to NAFE. The patterns of URVs burden in gene-sets expressed in inhibitory vs. excitatory neurons or receptors suggested a high burden in both in DEE but a differential involvement of inhibitory genes in GGE, while excitatory genes were predominantly affected in NAFE. Top ranking susceptibility genes from a recent genome-wide association study (GWAS) of generalized and focal epilepsies displayed a higher URVs burden in constrained coding regions in GGE and NAFE, respectively. Conclusions: Using exome-based gene-set burden analysis, we demonstrate that missense URVs affecting mainly constrained sites are enriched in neuronal genes in both common and rare severe epilepsy syndromes. Our results indicate a differential impact of these URVs in genes expressed in inhibitory vs. excitatory neurons and receptors in generalized vs. focal epilepsies. The excess of URVs in top-ranking GWAS risk-genes suggests a convergence of rare deleterious and common risk-variants in the pathogenesis of generalized and focal epilepsies. [less ▲]

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See detailUnderstanding the role of colorectal cancer-associated bacteria in colorectal cancer
Ternes, Dominik UL

Doctoral thesis (2021)

Mounting evidence from 16S rRNA-based or metagenomic analyses suggests that dysbiosis, a state of pathological microbial imbalance, is prevalent in the gut of patients with CRC. Numerous microbial taxa ... [more ▼]

Mounting evidence from 16S rRNA-based or metagenomic analyses suggests that dysbiosis, a state of pathological microbial imbalance, is prevalent in the gut of patients with CRC. Numerous microbial taxa have been identified of which representative isolate cultures can interact with cancer cells, further triggering distinct disease pathways in animal models. Nevertheless, how these complex interrelationships of a dysbiotic microbiota may be involved in the pathogenesis of CRC remains a fundamental question and requires multifaceted mechanistic studies. This thesis moves beyond observational studies, it integrates novel experimental approaches for the study of the gut microbiome in colorectal cancer. It incorporates current knowledge in the field as well as interdisciplinary approaches. My work aims at contributing to an ecosystem-level mechanistic understanding of the CRC-associated microbiome in the initiation and progression of the disease. In detail, the objective of my work comprised an integrative approach of microbiome-CRC interaction studies. We revised current knowledge on, and studied the CRC-associated bacteria, in particular Fusobacterium nucleatum (Fn) and Gemella morbillorum (Gm). We assessed their direct and indirect effects on CRC cells, their interactions with immune cells, as well as their tumor-modulating potential in vitro, in silico, and in vivo. The results presented in this thesis comprise new findings on human microbial cross-talk of Fn with CRC. We identified formate as a potential fusobacterial oncometabolite, which enhanced cancer incidence and progression via increased cancer stemness signaling. Furthermore, we discovered immune-suppressive functions of Gm in the context of CRC. With my work in collaboration projects, I contributed to the development of two novel approaches in anti-cancer therapy: First, to the establishment of a personalized in vitro model (iHuMiX) for the study of microbe-host-immune interactions in anti-cancer therapy, and second, to the validation of an in silico workflow that uses metabolic rewiring strategies for network-based drug target predictions for CRC therapy. Taken together, this thesis work broadened the mechanistic understanding of CRC-associated microbes and it contributed to potential strategies for the development of an improved CRC therapy. [less ▲]

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See detailDie "mentions honorifiques" - Kann man Patriotismus bewerten?
Wingerter, Elisabeth UL

Article for general public (2021)

Detailed reference viewed: 19 (1 UL)
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See detailQuand l’Europe emménageait au Luxembourg
Danescu, Elena UL

Article for general public (2021)

Lorsque le 9 mai 1950, le ministre français des Affaires étrangères (natif du Luxembourg) Robert Schuman (1886-1963) énonce ce que l’Histoire retiendra comme la « Déclaration Schuman » et propose la ... [more ▼]

Lorsque le 9 mai 1950, le ministre français des Affaires étrangères (natif du Luxembourg) Robert Schuman (1886-1963) énonce ce que l’Histoire retiendra comme la « Déclaration Schuman » et propose la création d’une Communauté européenne du charbon et de l'acier (CECA) réunissant les ennemies héréditaires d’antan - la France et l’Allemagne - personne n’imaginait que cette initiative censée forger une paix durable en Europe allait se concrétiser en moins d’un an. Et pourtant, la première Communauté européenne devient réalité le 18 avril 1951, lorsque les représentants de six pays - Robert Schuman (France), Konrad Adenauer (RFA), Paul van Zeeland et Joseph Meurice (Belgique), le comte Carlo Sforza (Italie), Dirk Stikker et Jan Van den Brink (Pays-Bas) et Joseph Bech (Luxembourg) – concluent le traité de Paris. Le traité CECA d’il y a 70 ans, presque jour pour jour, signifie le début du destin européen du Grand-Duché en tant qu’État fondateur et acteur de marque de la construction européenne, et de Luxembourg-ville, en tant que « première capitale de l’Europe ». [less ▲]

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See detailThird-country National Labour Workers' Mobility to and inside Europe during the COVID-19 Pandemic
Nienaber, Birte UL; Sommarribas, Adolfo UL

Scientific Conference (2021, April 15)

This presentation analyses the situation generated by the Covid-19 pandemic crisis regarding border closures and the reintroduction of temporary border controls at the internal borders in the EU and the ... [more ▼]

This presentation analyses the situation generated by the Covid-19 pandemic crisis regarding border closures and the reintroduction of temporary border controls at the internal borders in the EU and the impact that this border closures and the pandemic had on third-country nationals living or visiting the European Union. [less ▲]

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See detailFrictional interactions for non-localised beam-to-beam and beam-inside-beam contact
Magliulo, Marco; Lengiewicz, Jakub UL; Zilian, Andreas UL et al

in International Journal for Numerical Methods in Engineering (2021), 122(7), 1706-1731

This contribution presents the extensions of beam-to-beam and beam-inside-beam contact schemes of the same authors towards frictional interactions. Since the schemes are based on the beams’ true surfaces ... [more ▼]

This contribution presents the extensions of beam-to-beam and beam-inside-beam contact schemes of the same authors towards frictional interactions. Since the schemes are based on the beams’ true surfaces (instead of surfaces implicitly deduced from the beams’ centroid lines), the presented enhancements are not only able to account for frictional sliding in the beams’ axial directions, but also in the circumferential directions. Both the frictional beam-to-beam approach as well as the frictional beam-inside-beam approach are applicable to shear-deformable and shear-undeformable beams, as well as to beams with both circular and elliptical cross-sections (although the cross-sections must be rigid). A penalty formulation is used to treat unilateral and frictional contact constraints. FE implementation details are discussed, where automatic differentiation techniques are used to derive the implementations. Simulations involving large sliding displacements and large deformations are presented for both beam-to-beam and beam-inside-beam schemes. All simulation results are compared to those of the frictionless schemes. [less ▲]

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See detailPerspectives from the French-Luxembourgish and the Belgian-German Borders
Portas Vazquez, Irene UL; Brüll, Christoph UL

Presentation (2021, April 15)

When six European nations embarked on the integration process in the wake of World War II, there was no blueprint. Of course, the founders had a vision and shared ideals, but European integration has left ... [more ▼]

When six European nations embarked on the integration process in the wake of World War II, there was no blueprint. Of course, the founders had a vision and shared ideals, but European integration has left some citizens afraid of losing their identity and cultural heritage and an influx of immigrants has fuelled these fears. Building on this topic, this panel brings together researchers who focus on different aspects of what happens to history and heritage in multicultural European societies and particularly those in the border regions over time. New technologies are being used in innovated ways to communicate histories and memories to the public and with the goal to boost social and cultural participation. Since these former industrial regions in France, Luxembourg, Belgium, Netherlands and Germany have coped with similar challenges including the decline of the mining industry and changing borders, this panel aims to help us understand what opportunities lie in engaging local communities in research and how this can contribute to creating a sense of shared European heritage and identity. [less ▲]

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See detailMapping citizens’ reflections and perceptions of place-based experiences in the time of COVID-19
Jones, Catherine UL

Scientific Conference (2021, April 14)

Using a Citizen Science Approach, the ZesummenMaps project explores the emergent spatial interactions of our towns, cities and rural areas that arise from the COVID-19 pandemic and social distancing and ... [more ▼]

Using a Citizen Science Approach, the ZesummenMaps project explores the emergent spatial interactions of our towns, cities and rural areas that arise from the COVID-19 pandemic and social distancing and confinement policies in Luxembourg and the Greater Region. Citizens (residents, students, cross-border workers) reflect on their personal experiences of place during the crises. They contribute thoughts and perceptions through a collaborative community-mapping interface. This provides a foundation to explore, evaluate and understand the evolving perceptions and uses of public spaces, infrastructures and physical environments. Thus, creating an evidence-base of emerging spatial interactions to inform understanding of the impact of the "bleift doheem" policy (stay at home, confinement, lockdown) related to our perceptions and uses of our towns, cities and rural areas. [less ▲]

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