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See detailWandlung. Vom Hadern zum Versöhnen
Weber, Jean-Marie UL

Article for general public (2020)

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See detailSDN-based Misbehavior Detection System for Vehicular Networks
Boualouache, Abdelwahab UL; Soua, Ridha UL; Engel, Thomas UL

in 2020 IEEE 91st Vehicular Technology Conference (VTC2020-Spring) (2020, May)

Vehicular networks are vulnerable to a variety of internal attacks. Misbehavior Detection Systems (MDS) are preferred over the cryptography solutions to detect such attacks. However, the existing ... [more ▼]

Vehicular networks are vulnerable to a variety of internal attacks. Misbehavior Detection Systems (MDS) are preferred over the cryptography solutions to detect such attacks. However, the existing misbehavior detection systems are static and do not adapt to the context of vehicles. To this end, we exploit the Software-Defined Networking (SDN) paradigm to propose a context-aware MDS. Based on the context, our proposed system can tune security parameters to provide accurate detection with low false positives. Our system is Sybil attack-resistant and compliant with vehicular privacy standards. The simulation results show that, under different contexts, our system provides a high detection ratio and low false positives compared to a static MDS. [less ▲]

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See detailNaissance et extension du réseau Internet
Schafer, Valerie UL

Learning material (2020)

Du réseau ARPANET né dans le contexte de la guerre froide aux réseaux socio-numériques d’aujourd’hui, le développement des communications numériques en réseau a entraîné en cinquante ans des changements ... [more ▼]

Du réseau ARPANET né dans le contexte de la guerre froide aux réseaux socio-numériques d’aujourd’hui, le développement des communications numériques en réseau a entraîné en cinquante ans des changements majeurs, que ce soit en termes d’usages et de services mais aussi d’utilisateurs, passés d’un public plutôt restreint et universitaire au grand public. Le développement mondial d’Internet à partir de la décennie 1990 a eu un impact sur l’organisation de l’information et des communications numériques, ce qui n’est pas sans poser des défis techniques, mais aussi politiques, économiques et sociétaux. Il s’agit ici d’étudier Internet de sa naissance à la fin des années 1960 au World Wide Web de la fin des années 1980. Quelques tournants majeurs ont contribué à faire du « réseau des réseaux » et de ses services le vecteur d’une information à la fois de plus en plus mondialisée, mais aussi de plus en plus individualisée sous l’effet des moteurs de recherche, des filtres, des applications fermées développées par de grandes entreprises comme Google et des réseaux socio-numériques. [less ▲]

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See detailDynamic Adaptation of Software-defined Networks for IoT Systems: A Search-based Approach
Shin, Seung Yeob UL; Nejati, Shiva UL; Sabetzadeh, Mehrdad UL et al

in Proceedings of the 15th International Symposium on Software Engineering for Adaptive and Self-Managing Systems (SEAMS'20) (2020, May)

The concept of Internet of Things (IoT) has led to the development of many complex and critical systems such as smart emergency management systems. IoT-enabled applications typically depend on a ... [more ▼]

The concept of Internet of Things (IoT) has led to the development of many complex and critical systems such as smart emergency management systems. IoT-enabled applications typically depend on a communication network for transmitting large volumes of data in unpredictable and changing environments. These networks are prone to congestion when there is a burst in demand, e.g., as an emergency situation is unfolding, and therefore rely on configurable software-defined networks (SDN). In this paper, we propose a dynamic adaptive SDN configuration approach for IoT systems. The approach enables resolving congestion in real time while minimizing network utilization, data transmission delays and adaptation costs. Our approach builds on existing work in dynamic adaptive search-based software engineering (SBSE) to reconfigure an SDN while simultaneously ensuring multiple quality of service criteria. We evaluate our approach on an industrial national emergency management system, which is aimed at detecting disasters and emergencies, and facilitating recovery and rescue operations by providing first responders with a reliable communication infrastructure. Our results indicate that (1) our approach is able to efficiently and effectively adapt an SDN to dynamically resolve congestion, and (2) compared to two baseline data forwarding algorithms that are static and non-adaptive, our approach increases data transmission rate by a factor of at least 3 and decreases data loss by at least 70%. [less ▲]

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See detailThe Energy Consumption of Blockchain Technology: Beyond Myth
Sedlmeir, Johannes; Ulrich Buhl, Hans; Fridgen, Gilbert UL et al

in Business & Information Systems Engineering (2020)

When talking about blockchain technology in academia, business, and society, frequently generalizations are still heared about its – supposedly inherent – enormous energy consumption. This perception ... [more ▼]

When talking about blockchain technology in academia, business, and society, frequently generalizations are still heared about its – supposedly inherent – enormous energy consumption. This perception inevitably raises concerns about the further adoption of blockchain technology, a fact that inhibits rapid uptake of what is widely considered to be a groundbreaking and disruptive innovation. However, blockchain technology is far from homogeneous, meaning that blanket statements about its energy consumption should be reviewed with care. The article is meant to bring clarity to the topic in a holistic fashion,looking beyond claims regarding the energy consumption of Bitcoin, which have, so far, dominated the discussion. [less ▲]

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See detailDraft prEN 1994-1-1: 042020 + comments, Document
Schäfer, Markus UL; Hicks, Stephen; Banfi, Mike et al

Report (2020)

Development of second generation for Eurocode 4, part 1: prEN 1994-1-1: April 2020

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See detailBoîte à outils pour la formation des enseignants
Scheuer, Claude UL; Heck, Sandra UL

E-print/Working paper (2020)

Dans le cadre du projet BMC-EU (Compétences motrices de base en Europe), une boîte à outils pour la formation des enseignants reprenant le concept de formation ainsi qu’un manuel d'utilisation (BMC-EU ... [more ▼]

Dans le cadre du projet BMC-EU (Compétences motrices de base en Europe), une boîte à outils pour la formation des enseignants reprenant le concept de formation ainsi qu’un manuel d'utilisation (BMC-EU production intellectuelle 4) a été développée afin de soutenir la mise en œuvre de la formation aux tests MOBAK (boîte à outils pour l’enseignant-support théorique) la base du concept de compétences motrices de base (BMC-EU production intellectuelle 3 ; Scheuer & Heck, 2020). L'objectif de cette boîte à outils de soutien est d'être mis en œuvre principalement au niveau des cours réguliers d'éducation physique pour aider les enseignants d’éducation physique à adapter leurs contenus et leurs méthodes d'enseignement. La boîte à outils pour la formation des enseignants présente les éléments à mettre en œuvre lors de formations d'enseignants. Celles-ci sont structurées en une partie théorique et une partie pratique. Dans un premier temps, les enseignants sont familiarisés avec le concept MOBAK, la mesure, la procédure de test, le traitement des données et l’évaluation ainsi qu'avec l'interprétation des résultats du test. Dans une deuxième partie, ils apprennent à passer du diagnostic des compétences motrices de base des élèves et des forces et faiblesses identifiées dans l'évaluation à des interventions concrètes en utilisant le cadre de soutien MOBAK et les documents qui l'accompagnent sous la forme d'un support théorique (boîte à outils pour l’enseignant), prêt à être mis en œuvre dans des situations éducatives concrètes pour soutenir les élèves ayant des besoins supplémentaires en compétences motrices de base. Étant donné que la boîte à outils pour la formation des enseignants vise à soutenir et à faciliter la mise en œuvre de la formation théorique des enseignants de soutien modulaire pour les enseignants (Scheuer et Heck, 2020), il sera fait référence au concept et au construit des tests MOBAK (Herrmann, 2018), et au manuel de test MOBAK tout au long de ce document. [less ▲]

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See detailOpening minds to translanguaging pedagogies
Kirsch, Claudine UL

in System (2020)

Translanguaging pedagogies promise to capitalise on students’ language backgrounds, improve their academic achievements and address social inequalities. While research studies in monolingual, bilingual ... [more ▼]

Translanguaging pedagogies promise to capitalise on students’ language backgrounds, improve their academic achievements and address social inequalities. While research studies in monolingual, bilingual and multilingual contexts testify to the benefits of translanguaging for learning, well-being and identity-building, few studies focus on early childhood education and the use of more than two languages. Furthermore, little is known about the implementation of translanguaging pedagogies and the challenges faced by professionals. This article is based on a longitudinal research project which offered a professional development course to develop multilingual pedagogies in early childhood education in Luxembourg, where 63.7% of the 4-year-olds do not speak Luxembourgish as their home language. The article presents challenges which three practitioners faced when implementing a translanguaging pedagogy in their preschool classes as well as the ways in which they overcame them. They changed their negative stance to multilingual education, developed a social-constructivist leaning environment and monitored their language use. The findings shed light on the complexities of the implementation process and the support needed for professional learning. [less ▲]

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See detailLa Caverne, des Ténèbres à la Lumière
Meyers, Christian UL

Conference given outside the academic context (2020)

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See detailToolkit voor de training van docenten
Scheuer, Claude UL; Heck, Sandra UL

E-print/Working paper (2020)

In het kader van het BMC-EU project (Basismotorische competenties in Europa) heeft men op basis van het concept van basismotorische competenties (BMC-EU intellectuele output), een toolkit voor de training ... [more ▼]

In het kader van het BMC-EU project (Basismotorische competenties in Europa) heeft men op basis van het concept van basismotorische competenties (BMC-EU intellectuele output), een toolkit voor de training van docenten ontwikkeld met daarbij een bijbehorende gebruikershandleiding. Het doel van deze toolkit is voornamelijk om op het niveau van de reguliere lessen lichamelijke opvoeding aanpassingen te initiëren die van toepassing zijn op de inhoud en methoden in de lichamelijke opvoeding. De training voor docenten is opgedeeld in een praktisch en theoretisch deel. Allereerst worden leraren vertrouwd gemaakt met het MOBAK concept, de meting, testprocedure, de gegevensverwerking en evaluatie, evenals met de interpretatie van de testresultaten. In een tweede deel leren ze hoe ze van de diagnose van de basismotorische competenties van studenten en de sterke en zwakke punten die bij de beoordeling zijn geïdentificeerd, kunnen komen tot concrete interventies. Dit kan door het MOBAK kader en de bijbehorende hand-outs te gebruiken in de vorm van een modulaire ondersteunende toolkit. Deze toolkit kan ingezet worden in concrete onderwijssituaties om kinderen met aanvullende behoeften in basismotorische competenties te ondersteunen. Aangezien de training voor docenten de uitvoering van de toolkit voor de brede motorische ontwikkeling (Scheuer & Heck, 2020), gebaseerd op het MOBAK-concept en meting (Herrmann, 2018), wil ondersteunen en vergemakkelijken, wordt in dit document verwezen naar de ondersteunende toolkit en de MOBAK-testhandleiding. [less ▲]

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See detailFerramenta de apoio à Formação de Professores
Scheuer, Claude UL; Heck, Sandra UL

E-print/Working paper (2020)

No enquadramento do projeto BMC-EU (Competências motoras básicas na Europa), a ferramenta para a formação de professores consistindo num conceito de formação de professores juntamente com um manual de ... [more ▼]

No enquadramento do projeto BMC-EU (Competências motoras básicas na Europa), a ferramenta para a formação de professores consistindo num conceito de formação de professores juntamente com um manual de utilização (BMC-EU intellectual output 4) foi desenvolvido de modo a apoiar a implementação do kit modular de ferramentas para suporte aos professores considerando o conceito de competências motoras básicas (BMC-EU intellectual output 3; Scheuer & Heck, 2020). O objetivo deste kit de ferramentas de suporte é ser implementado principalmente ao nível da educação física regular para iniciar adaptações relativas ao conteúdo e métodos na instrução da educação física. A ferramenta de apoio à formação de professores contém materiais para implementar a formação de professores estruturada, com uma parte teórica e outra prática. Num primeiro passo, os professores estão familiarizados com o conceito MOBAK, medição, procedimentos do teste, tratamento dos dados e avaliação assim como com a interpretação dos resultados do teste. Numa segunda parte eles aprendem como diagnosticar as competências motoras básicas dos alunos e as forças e fraquezas identificadas na avaliação para concretizar intervenções usando o quadro de referência de suporte MOBAK e as fichas que acompanham o Kit de suporte, prontos para serem implementados em situações educativas concretas para apoiar estudantes com necessidades acrescidas nas competências motoras básicas. Como a ferramenta para a formação de professores visa apoiar e facilitar a implementação do Kit modular de ferramentas para suporte aos professores (Scheuer & Heck, 2020) baseado no conceito e medição do MOBAK (Herrmann, 2018), ao longo deste manual são fornecidas referências para suportar o kit de apoio e o manual do teste MOBAK . [less ▲]

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See detailTeacher training toolkit
Scheuer, Claude UL; Heck, Sandra UL

E-print/Working paper (2020)

In the frame of the BMC-EU project (Basic motor competencies in Europe), a teacher training toolkit consisting of a teacher training concept with an accompanying user manual (BMC-EU intellectual output 4 ... [more ▼]

In the frame of the BMC-EU project (Basic motor competencies in Europe), a teacher training toolkit consisting of a teacher training concept with an accompanying user manual (BMC-EU intellectual output 4) was developed in order to support the implementation of the modular support toolkit on the basis of the concept of basic motor competences (BMC-EU intellectual output 3; Scheuer & Heck, 2020). The aim of this support toolkit is to be implemented mainly at the level of regular physical education lessons to initiate adaptations regarding the content and methods in physical education instruction. The teacher training toolkit contains materials to implement teacher trainings structured in a theoretical and a practical part. In a first step, teachers are familiarized with the MOBAK concept, measurement, test procedure, data procession and evaluation as well as with the interpretation of test results. In a second part, they learn how to get from the diagnosis of the students’ basic motor competencies and the strengths and weaknesses identified in the assessment to concrete interventions by using the MOBAK support framework and the accompanying supportive handouts in form of a modular support toolkit, ready to be implemented in concrete educational situations to support students with additional needs in basic motor competencies. As the teacher training toolkit aims to support and facilitate the implementation of the Modular support toolkit for teachers (Scheuer & Heck, 2020) based on the MOBAK concept and measurement (Herrmann, 2018), reference to the support toolkit and the MOBAK Test manual is given throughout this document [less ▲]

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See detailΕργαλειοθήκη κατάρτισης για εκπαιδευτικούς
Scheuer, Claude UL; Heck, Sandra UL

E-print/Working paper (2020)

Στο πλαίσιο του έργου BMC-EU (Βασικές Κινητικές Δεξιότητες στην Ευρώπη), αναπτύχθηκε μία εργαλειοθήκη κατάρτισης για εκπαιδευτικούς, αποτελούμενη από τη γενική πρακτική ιδέα και ένα συνοδευτικό εγχειρίδιο ... [more ▼]

Στο πλαίσιο του έργου BMC-EU (Βασικές Κινητικές Δεξιότητες στην Ευρώπη), αναπτύχθηκε μία εργαλειοθήκη κατάρτισης για εκπαιδευτικούς, αποτελούμενη από τη γενική πρακτική ιδέα και ένα συνοδευτικό εγχειρίδιο χρήστη (BMC-EU πνευματική παραγωγή 4), για να υποστηρίξει την εφαρμογή της υποστηρικτικής εργαλειοθήκης με βάση την έννοια των βασικών κινητικών δεξιοτήτων (BMC-EU πνευματική παραγωγή 3; Scheuer & Heck, 2020). Ο σκοπός της εργαλειοθήκης αυτής είναι να εφαρμοστεί στα μαθήματα φυσικής αγωγής, ώστε να προσαρμοστούν κατάλληλα τόσο το περιεχόμενο όσο και οι μέθοδοι διδασκαλίας της φυσικής αγωγής. Η εργαλειοθήκη κατάρτισης για εκπαιδευτικούς περιέχει υλικό για τη δημιουργία πρακτικών προγραμμάτων για εκπαιδευτικούς δομημένα τόσο σε θεωρητικό, όσο και πρακτικό επίπεδο. Αρχικά, οι εκπαιδευτικοί εξοικειώνονται με την έννοια του ΜΟΒΑΚ, τις μετρήσεις, τη διαδικασία της εξέτασης, την επεξεργασία των δεδομένων και την αξιολόγηση, καθώς και με την ερμηνεία των αποτελεσμάτων. Στη συνέχεια, μαθαίνουν πώς να μεταβούν από τη διάγνωση των βασικών κινητικών δεξιοτήτων και τον εντοπισμό των αντίστοιχων ικανοτήτων των μαθητών, στον σχεδιασμό και την υλοποίηση συγκεκριμένων παρεμβάσεων με τη χρήση του υποστηρικτικού πλαισίου ΜΟΒΑΚ και των συνοδευτικών υποστηρικτικών φυλλαδίων, που είναι έτοιμα προς εφαρμογή σε συγκεκριμένες εκπαιδευτικές συνθήκες για την υποστήριξη μαθητών με πρόσθετες ανάγκες στις βασικές κινητικές δεξιότητες. Η εργαλειοθήκη κατάρτισης για εκπαιδευτικούς έχει ως σκοπό να υποστηρίξει και να διευκολύνει την εφαρμογή της Υποστηρικτικής εργαλειοθήκης για εκπαιδευτικούς (Scheuer & Heck, 2020), που βασίζεται στην έννοια και τις μετρήσεις ΜΟΒΑΚ (Herrmann, 2018). [less ▲]

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See detailToolkit für die Fortbildung von Sportlehrkräften
Scheuer, Claude UL; Heck, Sandra UL

E-print/Working paper (2020)

Im Rahmen des BMC-EU Projekts (Basic Motor Competencies in Europe) wurde ein Toolkit für die Fortbildung von Sportlehrkräften entwickelt, welches aus einem Fortbildungskonzept inklusive eines Handbuchs ... [more ▼]

Im Rahmen des BMC-EU Projekts (Basic Motor Competencies in Europe) wurde ein Toolkit für die Fortbildung von Sportlehrkräften entwickelt, welches aus einem Fortbildungskonzept inklusive eines Handbuchs (BMC-EU intellectual output 4) besteht. Die Entwicklung dieses Fortbildungskonzepts soll dazu beitragen, dass das modulare Support Toolkit auf der Basis des Konzepts der motorischen Basiskompetenzen (BMC-EU intellectual output 3; Scheuer & Heck, 2020) eingesetzt wird. Das Ziel dieses Support Toolkits ist hauptsächlich der Einsatz auf der Ebene des regulären Sportunterrichts um die Anpassungen, welche den Inhalt und die Methoden des Unterrichtens betreffen, voranzutreiben. Das Toolkit für die Fortbildung von Lehrkräften beinhaltet Materialen, die für die Durchführung einer strukturierten Lehrerfortbildung sowohl im theoretischen als auch im praktischen Teil benötigt werden. Im ersten Schritt werden die Lehrkräfte mit dem MOBAK Konzept, der Datenerhebung, der Testdurchführung, der Datenverarbeitung und –evaluation sowie mit der Interpretation der Testergebnisse vertraut gemacht. Im zweiten Schritt lernen die Lehrkräfte wie sie auf die Stärken und Schwächen ihrer Schülerinnen und Schüler, welche die Ergebnisse aus den Tests zu den motorischen Basiskompetenzen zeigen, fördern können, indem sie das MOBAK Support Toolkit verwenden. Dieses Toolkit kann direkt in konkrete Unterrichtsszenarien eingesetzt werden, um die Schülerinnen und Schüler mit zusätzlichem Förderbedarf in den motorischen Kompetenzen zu unterstützen. Da das Toolkit für die Fortbildung von Lehrkräfte darauf abzielt, die Durchführung des modularen Support Toolkits für Lehrkräfte (Scheuer & Heck, 2020) basierend auf dem MOBAK Konzept (Herrmann, 2018) zu unterstützen und zu ermöglichen, wird in diesem Dokument immer wieder auf das Support Toolkit und das MOBAK Testmanual verwiesen. [less ▲]

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See detailNástroj pre školenie učiteľov
Scheuer, Claude UL; Heck, Sandra UL

E-print/Working paper (2020)

V rámci projektu BMC-EU (Základné pohybové kompetencie v Európe) bol vytvorený súbor nástrojov odbornej prípravy učiteľov pozostávajúci z koncepcie odbornej prípravy učiteľov so sprievodným návodom na ... [more ▼]

V rámci projektu BMC-EU (Základné pohybové kompetencie v Európe) bol vytvorený súbor nástrojov odbornej prípravy učiteľov pozostávajúci z koncepcie odbornej prípravy učiteľov so sprievodným návodom na použitie (intelektuálny výstup BMC-EU 4), s cieľom podporiť využitie podporného metodického materiálu na základe koncepcie základných pohybových kompetencií (intelektuálny výstup BMC-EU 3; Scheuer & Heck, 2020). Cieľom tohto podporného materiálu je iniciovať na úrovni pravidelných hodín telesnej a športovej výchovy úpravy týkajúce sa obsahu a metód výučby telesnej a športovej výchovy. Nástroj pre školenie učiteľov obsahuje materiály na realizáciu školení učiteľov štruktúrovaných v teoretickej a praktickej časti. V prvom kroku sú učitelia oboznámení s koncepciou MOBAK, meraním, testovacím postupom, spracovaním a vyhodnotením údajov, ako aj s interpretáciou výsledkov testov. V druhej časti sa naučia, ako získať informácie z diagnostiky základných pohybových kompetencií žiakov a ich silných a slabých stránok identifikovaných pri hodnotení. Tiež sa naučia pracovať s pomocou podporného rámca MOBAK a sprievodných podporných nástrojov vo forme podpornej metodickej príručky, pripravenej na implementáciu v konkrétnych vzdelávacích situáciách na podporu žiakov s ďalšími potrebami v základných pohybových kompetenciách. Keďže cieľom súboru nástrojov prípravy učiteľov je podporiť a uľahčiť implementáciu metodickej príručky pre učiteľov (Scheuer & Heck, 2020) založenej na koncepte a meraní MOBAK (Herrmann, 2018), odkaz na podpornú metodickú príručku MOBAK je uvedený v tomto dokumente. [less ▲]

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See detailMokytojų rengimo priemonė
Scheuer, Claude UL; Heck, Sandra UL

E-print/Working paper (2020)

Vykdant BMC-EU projektą "Basic motor competencies in Europe" buvo sukurta mokytojų rengimo priemonė, susidedanti iš mokytojų rengimo sampratos ir vartotojo vadovo (BMC-EU intelektinės veiklos rezultatas ... [more ▼]

Vykdant BMC-EU projektą "Basic motor competencies in Europe" buvo sukurta mokytojų rengimo priemonė, susidedanti iš mokytojų rengimo sampratos ir vartotojo vadovo (BMC-EU intelektinės veiklos rezultatas Nr. 4), kurios tikslas - remiantis motorinių kompetencijų koncepcija padėti įgyvendinti modulinę palaikymo priemonę (BMC-EU intelektinės veiklos rezultatas Nr. 3; Scheuer ir Heck, 2020). Palaikymo priemonė skirta įprastoms kūno kultūros pamokoms, kurių metu skatinami turinio ir metodų pokyčiai ir jų taikymai. Mokytojų rengimo priemonėje pateikiama teorinė ir praktinė medžiaga. Pirmiausia mokytojai supažindinami su MOBAK koncepcija, matavimais, testavimo procedūra, duomenų apdorojimu ir vertinimu bei rezultatų aiškinimu. Antroje dalyje paaiškinama, kaip turimas žinias apie pagrindines moksleivių motorines kompetencijas ir vertinant išryškėjusias jų stipriąsias bei silpnąsias puses panaudoti praktiškai taikant MOBAK paramos sistemą ir kitą pagalbinę medžiagą konkrečiose mokymo situacijose atsižvelgiant į moksleivių poreikius ir pagrindines motorines kompetencijas. Kadangi mokytojų rengimo priemone siekiama palengvinti modulinės palaikymo priemonės mokytojams (Scheuer & Heck, 2020) įgyvendinimą remiantis MOBAK koncepcija ir matavimais (Herrmann, 2018), leidinyje dažnai mnima paramos sistema ir MOBAK vadovas. [less ▲]

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See detailSada nástrojů pro školení učitelů
Scheuer, Claude UL; Heck, Sandra UL

E-print/Working paper (2020)

V rámci projektu BMC-EU (Základní pohybové kompetence v Evropě) byla vyvinuta sada nástrojů pro školení učitelů, skládající se z koncepce školení učitelů a doprovodné uživatelské příručky (intelektuální ... [more ▼]

V rámci projektu BMC-EU (Základní pohybové kompetence v Evropě) byla vyvinuta sada nástrojů pro školení učitelů, skládající se z koncepce školení učitelů a doprovodné uživatelské příručky (intelektuální výstup BMC-EU 4) za účelem podpory implementace modulární podpůrné sady nástrojů na základě konceptu základních pohybových kompetencí (intelektuální výstup BMC-EU 3; Scheuer & Heck, 2020). Cílem této podpůrné sady nástrojů je zavedení do praxe především na úrovni pravidelných hodin tělesné výchovy tak, aby bylo možno začít s přizpůsobováním obsahu a metod výuky tělesné výchovy. Sada nástrojů pro školení učitelů obsahuje materiály pro realizaci školení rozdělené do teoretické a praktické části. V první části jsou učitelé seznámeni s konceptem MOBAK, měřením, testovacím postupem, zpracováním a vyhodnocováním dat a s interpretací výsledků testů. Ve druhé části se naučí, jak dospět od diagnostiky základních pohybových kompetencí studentů a od silných a slabých stránek identifikovaných při hodnocení k tomu, jak konkrétně zasáhnout pomocí podpůrného rámce MOBAK a doprovodných podpůrných materiálů ve formě modulární podpůrné sady nástrojů, která je připravena k zavádění do praxe v konkrétních vzdělávacích situacích za účelem podpory studentů s dalšími potřebami v základních pohybových kompetencích. Vzhledem k tomu, že sada nástrojů pro školení učitelů má za cíl podporovat a usnadňovat implementaci Modulární podpůrné sady pro učitele (Scheuer & Heck, 2020) založenou na konceptu a měření MOBAK (Herrmann, 2018), v celém tomto dokumentu se na podpůrnou sadu nástrojů a na testovací příručku MOBAK odkazuje. [less ▲]

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See detailManuale di formazione per gli insegnanti
Scheuer, Claude UL; Heck, Sandra UL

E-print/Working paper (2020)

Nell’ambito del progetto BMC-EU (Competenze motorie di base in Europa), è stato sviluppato un ulteriore documento utile alla formazione degli insegnanti, che consiste in un manuale di formazione (output ... [more ▼]

Nell’ambito del progetto BMC-EU (Competenze motorie di base in Europa), è stato sviluppato un ulteriore documento utile alla formazione degli insegnanti, che consiste in un manuale di formazione (output intellettuale BMC-EU 4), al fine di implementare il manuale modulare riguardante le competenze motorie di base (produzione intellettuale BMC-EU 3; Scheuer & Heck, 2020). Lo scopo di questo manuale è quello di ampliare i contenuti delle lezioni curriculari di educazione fisica, per proporre gli adattamenti riguardanti le attività ed i metodi. Il manuale contiene i materiali per implementare il processo di formazione degli insegnanti ed è strutturato in una parte teorica e una pratica. In una prima parte, gli insegnanti acquisiscono familiarità con la struttura del MOBAK, la misurazione, l’attuazione delle prove, l’elaborazione e e la valutazione dei dati, nonché con l'interpretazione dei risultati delle prove. In una seconda parte, imparano ad acquisire informazioni sulle competenze motorie di base degli allievi e sui punti di forza e di debolezza identificati nella valutazione. Inoltre, mediante proposte operative presenti nel manuale modulare del MOBAK e negli allegati, è possibile implementare i contesti di apprendimento per sostenere gli allievi con bisogni educativi speciali nelle competenze motorie di base. Il presente manuale per la formazione degli insegnanti è finalizzato a sostenere ed integrare il manuale modulare (Scheuer & Heck, 2020), basato sulla struttura e sui livelli del MOBAK (Herrmann, 2018). [less ▲]

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See detailFrom drug resistance mechanisms to microRNA function in melanoma
Kozar, Ines UL

Doctoral thesis (2020)

Cutaneous melanoma is an aggressive skin cancer that emerges from the unrestrained proliferation of melanocytes, which are the pigment producing cells in the basal layer of the epidermis. Despite the fact ... [more ▼]

Cutaneous melanoma is an aggressive skin cancer that emerges from the unrestrained proliferation of melanocytes, which are the pigment producing cells in the basal layer of the epidermis. Despite the fact that it only accounts for approximately 5% of all skin cancers, melanoma is responsible for the vast majority of skin cancer-related deaths. As more than half of the patients with sporadic melanoma harbour activating mutations in the protein kinase BRAF, the development of small kinase inhibitors targeting mutated BRAF led to an increased overall survival of patients with metastatic melanoma. Despite the initially promising results, the rapidly emerging resistance to these targeted therapies remains a serious clinical issue. To investigate the mechanisms underlying resistance to targeted therapies, we used in vitro BRAF-mutant drug-sensitive and drug-resistant melanoma cell models that were generated in our laboratory. First, we performed a kinase inhibitor library screening with the aim to identify novel kinase inhibitor combinations to circumvent or delay BRAF inhibitor-induced resistance. We have characterised synergistic kinase inhibitors targeting the MAPK pathway and the cell cycle showing promising effects in BRAF-mutant drug-sensitive and -resistant cells, which could be used as an effective sequential or alternative treatment option for late-stage melanoma patients. Additionally, we investigated the impact of BRAF inhibitors at the transcriptional level by comparing miRNome and transcriptome changes in drug-sensitive and -resistant melanoma cells. We identified miRNAs (e.g. miR-509, miR-708) and genes (e.g. PCSK2, AXL) that were distinctly differentially expressed in resistant compared to sensitive cells. Subsequent co-expression analyses revealed a low MITF/AXL ratio in a subset of resistant cell lines, suggesting that miRNAs might be involved in the switch from one molecular phenotype to another, thus conferring tolerance to targeted therapies. Finally, we applied a method based on cross-linking ligation and sequencing of hybrids (qCLASH) to provide a comprehensive snapshot of the miRNA targetome in our BRAF-mutant melanoma cells. To our knowledge, we implemented for the first time a CLASH-based method to cancer cells, and identified over 8k direct and distinct miRNA-target interactions in melanoma cells, including many with non-predicted and non-canonical binding characteristics, thus expanding the pool of miRNA-target interactions. Taken together, these results provide new insights into complex and heterogeneous responses to BRAF inhibition, adding an additional level of complexity to drug-induced (post-) transcriptional network rewiring in melanoma. [less ▲]

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