Last 7 days
Bookmark and Share    
See detailVorwort
Nonoa, Koku Gnatuloma UL; Kovacs, Teresa

in Nonoa, Koku Gnatuloma; Kovacs, Teresa (Eds.) Postdramatisches Theater als transkulturelles Theater. Eine transdisziplinäre Annäherung, (2018)

Detailed reference viewed: 5 (1 UL)
See detailZur Artikulation einer modernen europäischen Kultur im Theater als Text: vom engen zum erweiterten Text- bzw. Theaterbegriff
Nonoa, Koku Gnatuloma UL

in Zhu, Jianhua; Szurawitzki, Michael; Zhao, Jin (Eds.) Germanistik zwischen Tradition und Innovation: XIII. Kongress der Internationalen Vereinigung für Germanistik (IVG) (2018)

Detailed reference viewed: 13 (1 UL)
See detailPostdramatisches Theater als transkulturelles Theater. Eine transdisziplinäre Annäherung
Nonoa, Koku Gnatuloma UL; Kovacs, Teresa

Book published by Forum Modernes Theater - 1st ed. (2018)

Detailed reference viewed: 4 (0 UL)
Full Text
Peer Reviewed
See detailDirect evidence for cycloidal modulations in the thermal-fluctuation-stabilized spin spiral and skyrmion states of GaV 4 S 8
White, J. S.; Butykai, A.; Cubitt, R. et al

in Physical Review B (2018), 97(2), 020401

We report small-angle neutron scattering studies of the lacunar spinelGaV4S8,which reveal the long-wavelength magnetic phases to be cycloidally modulated. Upon cooling, these modulated phases, including a ... [more ▼]

We report small-angle neutron scattering studies of the lacunar spinelGaV4S8,which reveal the long-wavelength magnetic phases to be cycloidally modulated. Upon cooling, these modulated phases, including a recently proposed Néel-type skyrmion phase, transform into a simple ferromagnetic state. These results indicate the modulated phases in GaV4S8 gain their stability from thermal fluctuations, while at lower temperatures the ferromagnetic state emerges in accord with the strong easy-axis magnetic anisotropy. Crucially, our study provides microscopic evidence that the skyrmions in GaV4S8 indeed display a Néel-type helicity. More generally, our approach can be applied to evidence the helicity of any bulk skyrmion phase. [less ▲]

Detailed reference viewed: 29 (0 UL)
Full Text
Peer Reviewed
See detailOrdinary Pairing-Friendly Genus 2 Hyperelliptic Curves with Absolutely Simple Jacobians
Fotiadis, Georgios UL; Konstantinou, Elisavet

in International Conference on Mathematical Aspects of Computer and Information Sciences (2017, December 21)

Detailed reference viewed: 74 (5 UL)
See detailLe Cvce.eu, une infrastructure numérique
Gabellini, Marco UL

Presentation (2017, December 18)

Présentation des publications numériques sur le processus de la construction européenne analysé dans une perspective transnationale et multidimensionnelle sur le site cvce.eu. Les collections de ... [more ▼]

Présentation des publications numériques sur le processus de la construction européenne analysé dans une perspective transnationale et multidimensionnelle sur le site cvce.eu. Les collections de publications thématiques et le programme d’histoire orale, comprenant près de 100 interviews de personnalités européennes, constituent une approche innovante de la construction européenne. [less ▲]

Detailed reference viewed: 21 (5 UL)
See detailexpert meeting Digital Source Criticism
Scagliola, Stefania UL

Presentation (2017, December 18)

this expert meeting was meant to bring scholars together who conduct research on the topic of digital hermeneutics and digital source criticism, to exchange their views on the interpretation of this ... [more ▼]

this expert meeting was meant to bring scholars together who conduct research on the topic of digital hermeneutics and digital source criticism, to exchange their views on the interpretation of this concept. [less ▲]

Detailed reference viewed: 34 (2 UL)
Full Text
See detailNASA-FDL Artificial Intelligence in Planetary Science; Lunar Resource Mission
Backes, Dietmar UL

Scientific Conference (2017, December 15)

Detailed reference viewed: 79 (18 UL)
See detailLocalization and role of the molecular scaffold testin during mitosis and in actin-based processes
Mazzacavallo, Coralie UL

Doctoral thesis (2017)

The cytoskeleton is an important system in health and disease. Composed by three major classes of filaments, it ensures the maintaining of the cellular shape, it is involved in cell motility and cell ... [more ▼]

The cytoskeleton is an important system in health and disease. Composed by three major classes of filaments, it ensures the maintaining of the cellular shape, it is involved in cell motility and cell division. The complex regulation of this system is mediated by a various number of proteins which often display multiple and differential functions. Testin is one of these cytoskeletal proteins described in important processes involving the actin cytoskeleton such as cell migration and cell spreading. This thesis is dedicated to the study of testin during the cell division process which is mainly regulated by the actin and microtubule cytoskeleton. Our results provided evidence that, during mitosis, testin is able to dynamically localize to mitotic structures like centrosome, midzone and midbody. Further investigations of this localization, particularly in cytokinesis, permit to conclude that testin is a midbody bulge protein capable to concentrate to this intercellular bridge through its LIM1 and LIM2 domains. Testin is involved in the regulation of the actin cytoskeleton through being part of a protein complex with amongst other zyxin and talin, also able to concentrate to the midbody. Therefore, using RNAi experiments, we showed that the localization of testin to the midbody is zyxin and talin independent. In order to understand the potential function of testin during the cell division process, we initiate the identification of the potential partners of testin during mitosis. Based on the known interactors of testin, themselves described to localize to the midbody, we performed pull down as well as knock-down experiments. We also started the screening of potential mitotic partners of testin using the BioID approach. Given these observations about the localization of testin during mitosis the question arose whether testin plays a role in this process of cell division. Indeed, modulating the expression of testin results in different phenotypes. Overexpression of testin leads in faulty spindle formation or in a lack of abscission thus ultimately to an increase in multinucleated cells. Conversely, down regulation of testin leads to a perturbation of the nuclear shape and the microtubule structure of the midbody. Taken together, these data suggest that, in addition to its important role in actin-based processes in interphase, testin, a novel midbody bulge protein is involved in mitosis where it appears required for the integrity of a microtubule structure. [less ▲]

Detailed reference viewed: 42 (9 UL)
See detailLes regards experts sur l’Est en Allemagne et en Pologne : émergence, cristallisation et révision (1918-1972)
Bunout, Estelle UL

Doctoral thesis (2017)

La 1e Guerre mondiale fut le catalyseur de mutations sociales et techniques, qui suscitent de nouveaux besoins d’administration, matérialisés par l’émergence d’un nouveau groupe social: celui des experts ... [more ▼]

La 1e Guerre mondiale fut le catalyseur de mutations sociales et techniques, qui suscitent de nouveaux besoins d’administration, matérialisés par l’émergence d’un nouveau groupe social: celui des experts. Dans les États modernes allemands et polonais, un groupe particulier d’experts se détache, qui se spécialisent dans une thématique aux profondes racines culturelles : l’Est européen.Les changements de régime et de territoire entre 1918 et 1972 déstabilisent le cadre de référence des sociétés allemandes et polonaises, particulièrement entre 1939 et 1945. Cependant, l’historiographie des sciences de l’Est allemandes (Ostforschung) souligne les continuités personnelles, institutionnelles et conceptuelles fortes dans l’expertise de l’Est du « IIIe Reich » à l’Allemagne de l’Ouest. En Allemagne de l’Est et en Pologne, au contraire, le changement de régime après 1945 rend impossible toute continuité, mais la question de l’évolution de la pensée sur l’Est dans les cercles de l’expertise, qui eux se maintiennent, reste posée.En dépassant l’analyse de l’expertise en termes de subordination aux différents régimes politiques auxquels elle s’adresse, nous mettons en valeur les spécificités de l’expertise de l’Est. Elle se caractérise par un double ancrage dans l’imaginaire collectif et dans les pratiques scientifiques contemporaines, pour exprimer un but politique. Cet ancrage explique l’inertie dans les conceptions allemandes et polonaises de l’Est. L’approche comparatiste souligne tant la diversité des conceptions de l’Est, que les fonctions sociales comparables de l’Est, notamment celle d’ennemi et d’espace de projection nationale, passée et à venir [less ▲]

Detailed reference viewed: 42 (6 UL)
See detailA multi-omic view of phage-host dynamics within a mixed microbial community
Martinez Arbas, Susana UL

Presentation (2017, December 07)

Detailed reference viewed: 19 (0 UL)
Full Text
Peer Reviewed
See detailOn the non-stationary generalized Langevin Equation
Meyer, Hugues UL; Voigtmann, Thomas; Schilling, Tanja

in The Journal of chemical physics (2017), 147(21), 214110

In molecular dynamics simulations and single molecule experiments, observables are usually measured along dynamic trajectories and then averaged over an ensemble (“bundle”) of trajectories. Under ... [more ▼]

In molecular dynamics simulations and single molecule experiments, observables are usually measured along dynamic trajectories and then averaged over an ensemble (“bundle”) of trajectories. Under stationary conditions, the time-evolution of such averages is described by the generalized Langevin equation. By contrast, if the dynamics is not stationary, it is not a priori clear which form the equation of motion for an averaged observable has. We employ the formalism of time-dependent projection operator techniques to derive the equation of motion for a non-equilibrium trajectory-averaged observable as well as for its non-stationary auto-correlation function. The equation is similar in structure to the generalized Langevin equation but exhibits a time-dependent memory kernel as well as a fluctuating force that implicitly depends on the initial conditions of the process. We also derive a relation between this memory kernel and the autocorrelation function of the fluctuating force that has a structure similar to a fluctuation-dissipation relation. In addition, we show how the choice of the projection operator allows us to relate the Taylor expansion of the memory kernel to data that are accessible in MD simulations and experiments, thus allowing us to construct the equation of motion. As a numerical example, the procedure is applied to Brownian motion initialized in non-equilibrium conditions and is shown to be consistent with direct measurements from simulations. [less ▲]

Detailed reference viewed: 60 (1 UL)
Full Text
Peer Reviewed
See detailComputational Systems Biology Approach for the Study of Rheumatoid Arthritis: From a Molecular Map to a Dynamical Model
Singh, Vidisha; Ostaszewski, Marek UL; Kalliolias, George D. et al

in Genomics and Computational Biology (2017)

In this work we present a systematic effort to summarize current biological pathway knowledge concerning Rheumatoid Arthritis (RA). We are constructing a detailed molecular map based on exhaustive ... [more ▼]

In this work we present a systematic effort to summarize current biological pathway knowledge concerning Rheumatoid Arthritis (RA). We are constructing a detailed molecular map based on exhaustive literature scanning, strict curation criteria, re-evaluation of previously published attempts and most importantly experts’ advice. The RA map will be web-published in the coming months in the form of an interactive map, using the MINERVA platform, allowing for easy access, navigation and search of all molecular pathways implicated in RA, serving thus, as an on line knowledgebase for the disease. Moreover the map could be used as a template for Omics data visualization offering a first insight about the pathways affected in different experimental datasets. The second goal of the project is a dynamical study focused on synovial fibroblasts’ behavior under different initial conditions specific to RA, as recent studies have shown that synovial fibroblasts play a crucial role in driving the persistent, destructive characteristics of the disease. Leaning on the RA knowledgebase and using the web platform Cell Collective, we are currently building a Boolean large scale dynamical model for the study of RA fibroblasts’ activation [less ▲]

Detailed reference viewed: 74 (0 UL)
See detailNATO, the EU and the Arab Refugees Crisis in Europe
Al Hajjaji, Shams Al Din UL

Presentation (2017, December)

Detailed reference viewed: 8 (0 UL)
See detailEigentlich kann ich gar nichts
Baudson, Tanja Gabriele UL; Viergutz, Kathrin

Article for general public (2017)

Detailed reference viewed: 356 (0 UL)
See detailLe Schéischlach au Moyen Age: la „Spudelsgasse“
Pauly, Michel UL

in La corniche Nord de la Vieille Ville de Luxembourg. Architecture, Archéologie et Histoire (2017)

identification topographique et sociale de la rue 'Spudelsgasse' dans la ville médiévale de Luxembourg

Detailed reference viewed: 40 (2 UL)
Full Text
Peer Reviewed
See detailData Protection Directive (EU) 2016/680 for Police and Criminal Justice Authorities
Quintel, Teresa Alegra UL; Sajfert, Juraj

E-print/Working paper (2017)

In May 2018, the EU Data Protection Reform became applicable. In particular the General Data Protection Regulation (EU) 2016/679 (GDPR), which repealed Directive 95/46/EC on 25 May 2018 attracted much ... [more ▼]

In May 2018, the EU Data Protection Reform became applicable. In particular the General Data Protection Regulation (EU) 2016/679 (GDPR), which repealed Directive 95/46/EC on 25 May 2018 attracted much attention, albeit resembling its predecessor. Alongside the GDPR, the Reform encompassed a Directive (EU) 2016/680 establishing rules for the protection of individuals with regard to the processing of personal data by competent authorities for purposes of law enforcement (LED). The LED put forth great achievements in areas that had previously not been regulated by EU law. Therefore, the LED constitutes a major step forward in establishing a comprehensive EU data protection regime, as the first horizontal and legally binding instrument laying down the rules for national and cross-border processing of personal data in the area of law enforcement. Although the LED received way less attention than the GDPR, two main objectives of the Directive are too important to be neglected: the increased level of fundamental rights protection in the area of police and criminal justice, and the improved sharing of personal data between the Member States, as they will be able to rely on uniform data protection rules. The LED is a modern instrument, designed for the processing of personal data by Law Enforcement Authorities (LEAs) in the Digital Age, which is why there is no doubt that instruments such as the Directive are rapidly gaining in importance and visibility: firstly, an increased number of criminal acts is being committed online or with the help of online tools. Perpetrators of crime leave digital traces that may support LEAs in their tasks of crime prevention, detection, investigation and prosecution. Secondly, as perpetrators are becoming more tech-savvy, LEAs turned to new investigative techniques, including big data analytics. The term big data police technologies may include predictive systems that identify people or places suspected of crime, surveillance systems to monitor at-risk areas and search systems to mine data for investigative clues or to develop intelligence nets of helpful data for groups or across communities. Thirdly, EU rules on the processing of personal data by LEAs are undergoing consolidation, with the LED acting as a locomotive. The rules of the LED, which had to be transposed into the national laws of all 28 Member States and the four Schengen Area States (Norway, Iceland, Switzerland and Lichtenstein) by 6 May 2018, benefited from the attention given to the GDPR, as some of the Regulation’s solutions could simply be taken over. However, a number of provisions were developed specifically for the LED. This Article will give a general overview of the LED structure, its scope and briefly present the ten chapters. The second part of the Article will address four distinct features enshrined in the LED, focussing on automated individual decision-making (Article 11), the indirect exercise of data subject rights (Article 17), the obligation for competent authorities to keep logs (Article 25) and the provisions on international transfers (Articles 35-39). It will thereby critically assess the articles and point to both similarities and differences with regard to the GDPR. [less ▲]

Detailed reference viewed: 240 (6 UL)
Full Text
Peer Reviewed
See detailCellular models as tools for the study of the role of alpha-synuclein in Parkinson's disease
Pavlou, Maria Angeliki UL; Lázaro, Diana; Outeiro, Tiago

in Experimental Neurology (2017)

Neurodegenerative diseases are highly debilitating conditions characterised primarily by progressive neuronal loss and impairment of the nervous system. Parkinson's disease (PD) is one of the most common ... [more ▼]

Neurodegenerative diseases are highly debilitating conditions characterised primarily by progressive neuronal loss and impairment of the nervous system. Parkinson's disease (PD) is one of the most common of these disorders, affecting 1-2% of the population above the age of 65. Although the underlying mechanisms of PD have been extensively studied, we still lack a full understanding of the molecular underpinnings of the disease. Thus, the in vitro and in vivo models currently used are able to only partially recapitulate the typical phenotypes of the disease. Here, we review various cell culture models currently used to study the molecular basis of PD, with a focus on alpha-synuclein-associated molecular pathologies. We also discuss how different cell models may constitute powerful tools for high-throughput screening of molecules capable of modulating alpha-synuclein toxicity. [less ▲]

Detailed reference viewed: 66 (3 UL)