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See detailNanoporous gold decorated with silver nanoparticles as large area efficient SERS substrate
Ardini, Matteo; Huang, Jian-An; Sanchez-Sanchez, Carlos et al

in Proceedings of SPIE : The International Society for Optical Engineering (2017), 10346

Nanoporous gold is a very promising material platform for several plasmonic applications. Nanoporous gold can be formed by dealloying Au–Ag alloys, previously grown by means of Ag-Au co-sputtering. The ... [more ▼]

Nanoporous gold is a very promising material platform for several plasmonic applications. Nanoporous gold can be formed by dealloying Au–Ag alloys, previously grown by means of Ag-Au co-sputtering. The optical response is completely determined by the nanostructured film features, that only depend on the initial alloy composition. It has been extensively used as SERS substrate both as thin film and nanofabricated fancy designs. Here we explore the potential application of nanoporous gold as SERS substrate as it is coupled and decorated with Ag nanoparticles. Significant enhancement has been observed in comparison with bare nanoporous film. [less ▲]

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See detailFast and accurate human action recognition using RGB-D cameras
Ghorbel, Enjie UL

Doctoral thesis (2017)

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See detailSmallholder Farmers’ Adaptations of Agroecology in the Context of Livelihood Asset-Deprivation: Social and Ecological Consequences in Bilanga, Burkina Faso
Kapgen, Diane UL; Roudart, Laurence

in Tielkes, Eric (Ed.) Tropentag 2017: Future Agriculture: Social-ecological transitions and bio-cultural shifts (2017)

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See detailNote on A. Barbour’s paper on Stein’s method for diffusion approximations
Kasprzak, Mikolaj UL; Duncan, Andrew; Vollmer, Sebastian

in Electronic Communications in Probability (2017)

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See detailA Characterisation of Open Bisimilarity using an Intuitionistic Modal Logic
Ahn, Ki Yung; Horne, Ross James UL; Tiu, Alwen

in 28th International Conference on Concurrency Theory (CONCUR 2017). (2017)

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See detailModeling inter/trans granular failure using an anisotropic phase field approach
Nguyen, Thanh Tung UL; Réthoré, Julien; Yvonnet, Julien et al

in Fifth International Conference on Computational Modeling of Fracture and Failure of Materials and Structures (2017)

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See detailModelling of microcracking in image-based models of highly heterogeneous materials using the phase field method
Yvonnet, Julien; Nguyen, Thanh Tung UL; Bornert, Michel et al

in 7th GACM Colloquium on Computational Mechanics (2017)

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See detailA phase field method for modeling stress corrosion crack propagation induced by anodic dissolution
Nguyen, Thanh Tung UL; Réthoré, Julien; Baietto, Marie-Christine et al

in 14th International Conference on Fracture (2017)

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See detailComplement C1q is hydroxylated by collagen prolyl 4 hydroxylase and is sensitive to off-target inhibition by prolyl hydroxylase domain inhibitors that stabilize hypoxia-inducible factor.
Kiriakidis, Serafim; Hoer, Simon S.; Burrows, Natalie et al

in Kidney international (2017), 92(4), 900-908

Complement C1q is part of the C1 macromolecular complex that mediates the classical complement activation pathway: a major arm of innate immune defense. C1q is composed of A, B, and C chains that require ... [more ▼]

Complement C1q is part of the C1 macromolecular complex that mediates the classical complement activation pathway: a major arm of innate immune defense. C1q is composed of A, B, and C chains that require post-translational prolyl 4-hydroxylation of their N-terminal collagen-like domain to enable the formation of the functional triple helical multimers. The prolyl 4-hydroxylase(s) that hydroxylate C1q have not previously been identified. Recognized prolyl 4-hydroxylases include collagen prolyl-4-hydroxylases (CP4H) and the more recently described prolyl hydroxylase domain (PHD) enzymes that act as oxygen sensors regulating hypoxia-inducible factor (HIF). We show that several small-molecule prolyl hydroxylase inhibitors that activate HIF also potently suppress C1q secretion by human macrophages. However, reducing oxygenation to a level that activates HIF does not compromise C1q hydroxylation. In vitro studies showed that a C1q A chain peptide is not a substrate for PHD2 but is a substrate for CP4H1. Circulating levels of C1q did not differ between wild-type mice or mice with genetic deficits in PHD enzymes, but were reduced by prolyl hydroxylase inhibitors. Thus, C1q is hydroxylated by CP4H, but not the structurally related PHD hydroxylases. Hence, reduction of C1q levels may be an important off-target side effect of small molecule PHD inhibitors developed as treatments for renal anemia. [less ▲]

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See detailMolecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials.
Yeh, Tzu-Lan; Leissing, Thomas M.; Abboud, Martine I. et al

in Chemical science (2017), 8(11), 7651-7668

Inhibition of the human 2-oxoglutarate (2OG) dependent hypoxia inducible factor (HIF) prolyl hydroxylases (human PHD1-3) causes upregulation of HIF, thus promoting erythropoiesis and is therefore of ... [more ▼]

Inhibition of the human 2-oxoglutarate (2OG) dependent hypoxia inducible factor (HIF) prolyl hydroxylases (human PHD1-3) causes upregulation of HIF, thus promoting erythropoiesis and is therefore of therapeutic interest. We describe cellular, biophysical, and biochemical studies comparing four PHD inhibitors currently in clinical trials for anaemia treatment, that describe their mechanisms of action, potency against isolated enzymes and in cells, and selectivities versus representatives of other human 2OG oxygenase subfamilies. The 'clinical' PHD inhibitors are potent inhibitors of PHD catalyzed hydroxylation of the HIF-alpha oxygen dependent degradation domains (ODDs), and selective against most, but not all, representatives of other human 2OG dependent dioxygenase subfamilies. Crystallographic and NMR studies provide insights into the different active site binding modes of the inhibitors. Cell-based results reveal the inhibitors have similar effects on the upregulation of HIF target genes, but differ in the kinetics of their effects and in extent of inhibition of hydroxylation of the N- and C-terminal ODDs; the latter differences correlate with the biophysical observations. [less ▲]

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See detailGlucose Metabolism and Oxygen Availability Govern Reactivation of the Latent Human Retrovirus HTLV-1.
Kulkarni, Anurag; Mateus, Manuel; Thinnes, Cyrille UL et al

in Cell chemical biology (2017), 24(11), 1377-13873

The human retrovirus HTLV-1 causes a hematological malignancy or neuroinflammatory disease in approximately 10% of infected individuals. HTLV-1 primarily infects CD4(+) T lymphocytes and persists as a ... [more ▼]

The human retrovirus HTLV-1 causes a hematological malignancy or neuroinflammatory disease in approximately 10% of infected individuals. HTLV-1 primarily infects CD4(+) T lymphocytes and persists as a provirus integrated in their genome. HTLV-1 appears transcriptionally latent in freshly isolated cells; however, the chronically active anti-HTLV-1 cytotoxic T cell response observed in infected individuals indicates frequent proviral expression in vivo. The kinetics and regulation of HTLV-1 proviral expression in vivo are poorly understood. By using hypoxia, small-molecule hypoxia mimics, and inhibitors of specific metabolic pathways, we show that physiologically relevant levels of hypoxia, as routinely encountered by circulating T cells in the lymphoid organs and bone marrow, significantly enhance HTLV-1 reactivation from latency. Furthermore, culturing naturally infected CD4(+) T cells in glucose-free medium or chemical inhibition of glycolysis or the mitochondrial electron transport chain strongly suppresses HTLV-1 plus-strand transcription. We conclude that glucose metabolism and oxygen tension regulate HTLV-1 proviral latency and reactivation in vivo. [less ▲]

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See detailLauenstein im Bild. Zur Materialität und sozialen Bedeutung von Photographie
Priem, Karin UL

Scientific Conference (2017)

Der Beitrag widmet sich der Analyse eines Photoalbums, das im Rahmen der Debatten auf der Burg Lauenstein über die Neuordnung Deutschlands nach dem Krieg entstanden ist und im Jahre 1917 von dem Verleger ... [more ▼]

Der Beitrag widmet sich der Analyse eines Photoalbums, das im Rahmen der Debatten auf der Burg Lauenstein über die Neuordnung Deutschlands nach dem Krieg entstanden ist und im Jahre 1917 von dem Verleger Eugen Diederichs in Auftrag gegeben wurde. Das Album dokumentiert einen eindrucksvollen Reigen zeitgenössischer Persönlichkeiten wie zum Beispiel Marianne und Max Weber, Ferdinand Tönnies, Gertrud Bäumer, Ernst Toller, Eugen Diederichs, Theodor Heuss und Friedrich Meinecke. [less ▲]

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See detailPhotography as humanitarian action: David Seymour’s Children of Europe
Priem, Karin UL; Herman, Frederik

Scientific Conference (2017)

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See detailSkill Mismatch in Labor Markets
Polachek, Solomon; Pouliakas, Konstantinos; Russo, Giovanni et al

Book published by Emerald - 45 (2017)

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See detailThe Visual and History Practice in the Digital Age
Allender, Tim; Dussel, Inés; Grosvenor, Ian et al

Scientific Conference (2017)

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See detailJürgen Daiber, Franz Kafka und der Lärm. Klanglandschaften der frühen Moderne.
Küpper, Achim UL

in Arbitrium (2017), 35(1), 117-119

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See detailThe Eye of the Machine: Labour Sciences and the Mechanical Registration of the Human Body
Herman, Frederik; Priem, Karin UL

Scientific Conference (2017)

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See detailHumanitarian Photography in Post War Europe
Priem, Karin UL

Scientific Conference (2017)

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See detailDocumentation TwinLife Data: Cognitive Abilities.
Gottschling, Juliana UL

E-print/Working paper (2017)

Detailed reference viewed: 20 (1 UL)