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See detailRobotix-Academy Conference for Industrial Robotics (RACIR) 2018
Müller, Rainer; Plapper, Peter UL; Brüls, Olivier et al

Book published by Shaker Verlag - 1st ed (2018)

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See detailIndustry 4.0 – Implementation of an automated assembly line in a wooden modular house production plant: The case Leko Labs
de Vincenzo, Vincenzo UL; Hichri, Bassem UL; Plapper, Peter UL

in De vincenzo, Vincenzo; Hichri, Bassem; Plapper, Peter (Eds.) Robotix-Academy Conference for Industrial Robotics (RACIR) 2018 (2018, November)

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See detailEfficient Implementation of the SHA-512 Hash Function for 8-bit AVR Microcontrollers
Cheng, Hao UL; Dinu, Dumitru-Daniel; Groszschädl, Johann UL

in Lanet, Jean-Louis; Toma, Cristian (Eds.) Innovative Security Solutions for Information Technology and Communications, 11th International Conference, SecITC 2018, Bucharest, Romania, November 8-9, 2018, Revised Selected Papers (2018, November)

SHA-512 is a member of the SHA-2 family of cryptographic hash algorithms that is based on a Davies-Mayer compression function operating on eight 64-bit words to produce a 512-bit digest. It provides ... [more ▼]

SHA-512 is a member of the SHA-2 family of cryptographic hash algorithms that is based on a Davies-Mayer compression function operating on eight 64-bit words to produce a 512-bit digest. It provides strong resistance to collision and preimage attacks, and is assumed to remain secure in the dawning era of quantum computers. However, the compression function of SHA-512 is challenging to implement on small 8 and 16-bit microcontrollers because of their limited register space and the fact that 64-bit rotations are generally slow on such devices. In this paper, we present the first highly-optimized Assembler implementation of SHA-512 for the ATmega family of 8-bit AVR microcontrollers. We introduce a special optimization technique for the compression function based on a duplication of the eight working variables so that they can be more efficiently loaded from RAM via the indirect addressing mode with displacement (using the ldd and std instruction). In this way, we were able to achieve high performance without unrolling the main loop of the compression function, thereby keeping the code size small. When executed on an 8-bit AVR ATmega128 microcontroller, the compression function takes slightly less than 60k clock cycles, which corresponds to a compression rate of roughly 467 cycles per byte. The binary code size of the full SHA-512 implementation providing a standard Init-Update-Final (IUF) interface amounts to approximately 3.5 kB. [less ▲]

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See detailPower Minimizer Symbol-Level Precoding: A Closed-Form Sub-Optimal Solution
Haqiqatnejad, Alireza UL; Kayhan, Farbod UL; Ottersten, Björn UL

in IEEE Signal Processing Letters (2018), 25(11), 1730-1734

In this letter, we study the optimal solution of multiuser symbol-level precoding (SLP) for minimization of the total transmit power under given signal-to-interference-plus noise ratio (SINR) constraints ... [more ▼]

In this letter, we study the optimal solution of multiuser symbol-level precoding (SLP) for minimization of the total transmit power under given signal-to-interference-plus noise ratio (SINR) constraints. Adopting the distance preserving constructive interference regions (DPCIR), we first derive a simplified reformulation of the problem. Then, we analyze the structure of the optimal solution using the Karush-Kuhn-Tucker (KKT) optimality conditions. This leads us to obtain a closed-form sub-optimal SLP solution (CF-SLP) for the original problem. Meanwhile, we obtain the necessary and sufficient condition under which the power minimizer SLP is equivalent to the conventional zero-forcing beamforming (ZFBF). Simulation results show that CF-SLP provides significant gains over ZFBF, while performing quite close to the optimal SLP in scenarios with rather small number of users. The results further indicate that the CF-SLP method has a reduction of order 1000 in computational time compared to the optimal solution. [less ▲]

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See detailUnderstanding the role of genetic variability in LRRK2 in Indian population
Krüger, Rejko UL; Kishore, Asha; Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease (COURAGE-PD) et al

in Movement Disorders (2018)

Background: Genetic variability in LRRK2 has been unequivocally established as a major risk factor for familial and sporadic forms of PD in ethnically diverse populations. Objectives: To resolve the role ... [more ▼]

Background: Genetic variability in LRRK2 has been unequivocally established as a major risk factor for familial and sporadic forms of PD in ethnically diverse populations. Objectives: To resolve the role of LRRK2 in the Indian population. Methods: We performed targeted resequencing of the LRRK2 locus in 288 cases and 298 controls and resolved the haplotypic structure of LRRK2 in a combined cohort of 800 cases and 402 controls in the Indian population. We assessed the frequency of novel missense variants in the white and East Asian population by leveraging exome sequencing and densely genotype data, respectively. We did computational modeling and biochemical approach to infer the potential role of novel variants impacting the LRRK2 protein function. Finally, we assessed the phosphorylation activity of identified novel coding variants in the LRRK2 gene. Results: We identified four novel missense variants with frequency ranging from 0.0008% to 0.002% specific for the Indian population, encompassing armadillo and kinase domains of the LRRK2 protein. A common genetic variability within LRRK2 may contribute to increased risk, but it was nonsignificant after correcting for multiple testing, because of small cohort size. The computational modeling showed destabilizing effect on the LRRK2 function. In comparison to the wild-type, the kinase domain variant showed 4-fold increase in the kinase activity. Conclusions: Our study, for the first time, identified novel missense variants for LRRK2, specific for the Indian population, and showed that a novel missense variant in the kinase domain modifies kinase activity in vitro. [less ▲]

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See detailMigration patterns in Luxembourg
Stogianni, Maria UL

E-print/Working paper (2018)

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See detailPolicy and research priorities of the World Young Leaders in Dementia (WYLD) network
Leist, Anja UL

Scientific Conference (2018, October 30)

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See detailThe Virtual Metabolic Human database: integrating human and gut microbiome metabolism with nutrition and disease
Noronha, Alberto UL; Modamio Chamarro, Jennifer UL; Jarosz, Yohan UL et al

in Nucleic Acids Research (2018)

A multitude of factors contribute to complex diseases and can be measured with ‘omics’ methods. Databases facilitate data interpretation for underlying mechanisms. Here, we describe the Virtual Metabolic ... [more ▼]

A multitude of factors contribute to complex diseases and can be measured with ‘omics’ methods. Databases facilitate data interpretation for underlying mechanisms. Here, we describe the Virtual Metabolic Human (VMH, www.vmh.life) database encapsulating current knowledge of human metabolism within five interlinked resources ‘Human metabolism’, ‘Gut microbiome’, ‘Disease’, ‘Nutrition’, and ‘ReconMaps’. The VMH captures 5180 unique metabolites, 17 730 unique reactions, 3695 human genes, 255 Mendelian diseases, 818 microbes, 632 685 microbial genes and 8790 food items. The VMH’s unique features are (i) the hosting of the metabolic reconstructions of human and gut microbes amenable for metabolic modeling; (ii) seven human metabolic maps for data visualization; (iii) a nutrition designer; (iv) a user-friendly webpage and application-programming interface to access its content; (v) user feedback option for community engagement and (vi) the connection of its entities to 57 other web resources. The VMH represents a novel, interdisciplinary database for data interpretation and hypothesis generation to the biomedical community. [less ▲]

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See detailMicromagnetic simulations for understanding magnetic SANS
Michels, Andreas UL

Scientific Conference (2018, October 29)

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See detailThe Luxembourg Parkinson’s Study: A Comprehensive Approach for Stratification and Early Diagnosis
Hipp Epouse D'amico, Géraldine UL; Vaillant, Michel; Diederich, Nico J. et al

in Frontiers in Aging Neuroscience (2018), 10

While genetic advances have successfully defined part of the complexity in Parkinson’s disease (PD), the clinical characterization of phenotypes remains challenging. Therapeutic trials and cohort studies ... [more ▼]

While genetic advances have successfully defined part of the complexity in Parkinson’s disease (PD), the clinical characterization of phenotypes remains challenging. Therapeutic trials and cohort studies typically include patients with earlier disease stages and exclude comorbidities, thus ignoring a substantial part of the real-world PD population. To account for these limitations, we implemented the Luxembourg PD study as a comprehensive clinical, molecular and device-based approach including patients with typical PD and atypical parkinsonism, irrespective of their disease stage, age, comorbidities, or linguistic background. To provide a large, longitudinally followed, and deeply phenotyped set of patients and controls for clinical and fundamental research on PD, we implemented an open-source digital platform that can be harmonized with international PD cohort studies. Our interests also reflect Luxembourg-specific areas of PD research, including vision, gait, and cognition. This effort is flanked by comprehensive biosampling efforts assuring high quality and sustained availability of body liquids and tissue biopsies. We provide evidence for the feasibility of such a cohort program with deep phenotyping and high quality biosampling on parkinsonism in an environment with structural specificities and alert the international research community to our willingness to collaborate with other centers. The combination of advanced clinical phenotyping approaches including device-based assessment will create a comprehensive assessment of the disease and its variants, its interaction with comorbidities and its progression. We envision the Luxembourg Parkinson’s study as an important research platform for defining early diagnosis and progression markers that translate into stratified treatment approaches. [less ▲]

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See detailAttitudes toward students with special educational needs and inclusive education: Studies in the Luxembourgish general and educational context
Krischler, Mireille UL

Doctoral thesis (2018)

More and more countries are moving toward adopting inclusive school systems. In this context, research has clearly indicated that in order to ensure the successful implementation of this concept, it is ... [more ▼]

More and more countries are moving toward adopting inclusive school systems. In this context, research has clearly indicated that in order to ensure the successful implementation of this concept, it is crucial for all people involved in the process of restructuring to have positive attitudes. However, even if many studies on different actors´ attitudes toward inclusive education have already been published, the stance of people in Luxembourg on this topic remains unclear. This dissertation uses the Bioecological Model of Inclusive Education to provide an overview of the environmental factors that play key roles in the implementation of inclusive education, such as the decisions made on a governmental level and the attitudes of the Luxemburgish general population as well as those of pre- and in-service teachers. The materials used in the current studies are based on the Three Component Model of attitudes to investigate attitudes toward the general idea of an inclusive school system and (the inclusion of) students with learning difficulties and challenging behavior. To avoid issues with social desirability, implicit measurement tools were additionally used in the first three studies. An analysis of the recent changes in the Luxemburgish educational system revealed that a range of barriers still persist. In this regard, results have shown that the idea of an inclusive school system is embraced by the Luxemburgish general population. By contrast, attitudes toward (the inclusion of) students with special educational needs tend to be negative. Pre- and in-service teachers’ ratings of student achievement of students with learning difficulties and challenging behavior (in Study 2) were below average and influenced by stereotypical beliefs. However, teachers with experience in inclusive classrooms gave the highest ratings of both groups of students. These findings raised the question of whether, in addition to experience, the definition of inclusive education plays a role in the development of positive attitudes. The results of Study 4 indeed revealed associations between definitions and attitudes, whereby people who emphasized that inclusive education is about valuing the needs of all students held the most positive attitudes. Notably, the individual readiness of teachers to implement inclusive education was also related to the definition. Implications of the findings for the educational system and the society as well as for (attitude) research in the field of inclusive education are outlined, and directions for future research are given. [less ▲]

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See detailSustainability: problematizing fragility and ephemerality in digital research - Workshop
Schafer, Valerie UL; Fickers, Andreas UL

Presentation (2018, October 26)

404 not found, closed and opaque corpora, websites disappearance after a few years, obsolete tools, problems of maintenance … this workshop wishes to explore the instability of data, of their digital ... [more ▼]

404 not found, closed and opaque corpora, websites disappearance after a few years, obsolete tools, problems of maintenance … this workshop wishes to explore the instability of data, of their digital (digitalized or/and born-digital) heritage, of digital technologies and tools, the numerous transformations of devices, platforms, terms of use and the tensions between this instability and the necessary stability and reproducibility of research. How should researchers deal at the same time with the ephemeral, the flow, the obsolescence and the concern of knowledge production? How is it possible to reconciliate the temporality of research and the short cycles of technologies? This workshop aims at introducing and identifying the challenges of sustainability and durability which are too often underestimated in digital research and rarely presented to students when introducing tools and research methods. This 120 minutes workshop will be organized in three parts as follows: - Identifying the levels, steps, in which sustainability and durability of a digital research are challenged, from the shaping and sharing of corpora to the maintenance of research results and digital productions. This will be based on the participants experiences and on several examples of research projects; - Mapping the issues and existing solutions such as digital research infrastructures, permanent identifiers, licenses, but also obstacles and limits (such as author rights …) that researchers have to face or take into account; - Creating practical guidelines that could be used by scholars and students. This workshop expands a research project conducted by Christine Barats (Céditec, Université Paris- Est Créteil), Andreas Fickers (Head of C2DH, University of Luxembourg), Valérie Schafer (C2DH, University of Luxembourg). [less ▲]

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See detail“There Was No Green Tick”: Discovering the Functions of a Widget in a Joint Problem-Solving Activity and the Consequences for the Participants’ Discovering Process
Sunnen, Patrick UL; Arend, Béatrice UL; Maquil, Valérie

in Multimodal Technologies and Interaction (2018), 2(4), 1-23

In recent years, tangible user interfaces (TUI) have gained in popularity in educational contexts, among others to implement problem-solving and discovery learning science activities. In the context of an ... [more ▼]

In recent years, tangible user interfaces (TUI) have gained in popularity in educational contexts, among others to implement problem-solving and discovery learning science activities. In the context of an interdisciplinary and cross-institutional collaboration, we conducted a multimodal EMCA-based video user study involving a TUI-mediated bicycle mechanics simulation. This article focusses on the discovering work of a group of three students with regard to a particular tangible object (a red button), designed to support participants engagement with the underlying physics aspects and its consequences with regard to their engagement with the targeted mechanics aspects. [less ▲]

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See detailZebrafish models of Dravet syndrome: discovery of antiseizure drug leads and analysis of behavioural comorbidities
Jacmin, Maxime UL

Doctoral thesis (2018)

Dravet syndrome (DS) is one of the most frequent genetic epilepsies, with an incidence of 1/30,000. Most DS patients are pharmacoresistant, in that they do not respond adequately to currently available ... [more ▼]

Dravet syndrome (DS) is one of the most frequent genetic epilepsies, with an incidence of 1/30,000. Most DS patients are pharmacoresistant, in that they do not respond adequately to currently available anticonvulsant drugs (ASDs). Beside the seizure occurrence in these patients, many DS patients also suffer from cognitive impairment that can be aggravated by some of the seizure medications prescribed. Preclinical models such as mouse models of Dravet syndrome have been developed and described to exhibit cognitive deficits similar to those of DS patients, but are only suitable for the evaluation of small number of compounds, thereby limiting their utility for drug discovery. An animal model with higher screening throughput would therefore be of value for drug discovery efforts focused on seizure reduction and decrease of the comorbidities associated with DS. Recent studies on zebrafish have demonstrated its ability to be a promising in vivo model for DS. Two different zebrafish DS models - one based on a loss-of-function mutation in the zebrafish ortholog of SCN1A, the other based on an antisense knockdown of this gene - exhibit seizure-like behaviour and epileptiform discharges that are exacerbated by hyperthermia. The mutant line was also described to display greater anxiety levels. In this Doctoral thesis project, we are investigating these zebrafish DS models with regard to (1) their seizure occurrence and potential reduction following exposure to several anticonvulsant drug candidates, and (2), their cognitive functions in order to determine possible similarities with cognitive impairment in human DS patients. Our results indicate these zebrafish DS models to exhibit memory impairment and higher anxiety levels. These findings provide an initial insight into the resemblance between human patients and zebrafish in terms of comorbidities. Finally, we also identified several novel anticonvulsant compounds and drug candidates with antiseizure activity in these zebrafish DS models. [less ▲]

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See detailWorkshop 'Strategies for Using Digital Sources in the Classroom
Randolph, John; Zaagsma, Gerben UL

Presentation (2018, October 26)

Given the current abundance of available digital resources for historians (retro-digitized as well as born-digital materials), there is an urgent question of how to engage with these resources in the ... [more ▼]

Given the current abundance of available digital resources for historians (retro-digitized as well as born-digital materials), there is an urgent question of how to engage with these resources in the history classroom. How do we teach the differences between "online" and "offline" materials and they ways in which historians can approach them? How do we deal with issues of decontextualization and the changes brought about in historical research practices by working with digital objects? The SourceLab project tackles these issues by letting students create digital editions of historical artefacts and thereby engage them in the making of history. The Ranke.2 project provides lessons that teaches students what digital source criticism is. In this workshop we will discuss in what ways teachers use digital resources in the classroom, and what strategies, if any, they use to sensitize their students to the specificities of online materials as opposed to those found in the archive. The outcome could be a working paper which discusses the pros and cons of various approaches. [less ▲]

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See detailDoing Digital Hermeneutics in an Interdisciplinary Setting
van der Heijden, Tim UL

Scientific Conference (2018, October 25)

This contribution examines the conference theme from the perspective of the Doctoral Training Unit (DTU) in ‘Digital History and Hermeneutics’, a four-year interdisciplinary research and training program ... [more ▼]

This contribution examines the conference theme from the perspective of the Doctoral Training Unit (DTU) in ‘Digital History and Hermeneutics’, a four-year interdisciplinary research and training program funded by the Luxembourg National Research Fund (FNR) and hosted by the Centre for Contemporary and Digital History (C2DH) at the University of Luxembourg. The DTU is designed as an experimental platform for collaboration, in which thirteen doctoral candidates with different disciplinary backgrounds – from history, linguistics and philosophy to computer and information science – study and reflect on the epistemological and methodological implications of the ‘digital turn’ on historical research. The presentation takes a look back at the project’s first year, in which the doctoral candidates were introduced to various skills and methods in digital humanities, including text mining, digital source criticism, database structures, data visualization, GIS analysis, tool criticism and algorithmic critique. Based on experiences by the doctoral students themselves as reflected in semi-structured interviews, as well as drawing upon studies in interdisciplinarity, digital humanities, and the role of space(s) in scientific collaborations, the possibilities and challenges will be explored of doing digital history and hermeneutics in an interdisciplinary setting. [less ▲]

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See detailTwitter data as primary sources for historians: a critical approach
Clavert, Frédéric UL; Papastamkou, Sofia

Scientific Conference (2018, October 25)

Detailed reference viewed: 89 (7 UL)