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See detailLet us empower the WFD to prevent risks of chemical pollution in European rivers and lakes
Brack, Werner; Ait-Aissa, Selim; Altenburger, Rolf et al

in Environmental Sciences Europe (2019), 31(1), 1-3

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See detailHigh-resolution mass spectrometry to complement monitoring and track emerging chemicals and pollution trends in European water resources
Brack, Werner; Hollender, Juliane; de Alda, Miren López et al

in Environmental Sciences Europe (2019), 31(1), 62

Currently, chemical monitoring based on priority substances fails to consider the majority of known environmental micropollutants not to mention the unexpected and unknown chemicals that may contribute to ... [more ▼]

Currently, chemical monitoring based on priority substances fails to consider the majority of known environmental micropollutants not to mention the unexpected and unknown chemicals that may contribute to the toxic risk of complex mixtures present in the environment. Complementing component- and effect-based monitoring with wide-scope target, suspect, and non-target screening (NTS) based on high-resolution mass spectrometry (HRMS) data is recommended to support environmental impact and risk assessment. This will allow for detection of newly emerging compounds and transformation products, retrospective monitoring efforts, and the identification of possible drivers of toxicity by correlation with effects or modelling of expected effects for future and abatement scenarios. HRMS is becoming increasingly available in many laboratories. Thus, the time is right to establish and harmonize screening methods, train staff, and record HRMS data for samples from regular monitoring events and surveys. This will strongly enhance the value of chemical monitoring data for evaluating complex chemical pollution problems, at limited additional costs. Collaboration and data exchange on a European-to-global scale is essential to maximize the benefit of chemical screening. Freely accessible data platforms, inter-laboratory trials, and the involvement of international partners and networks are recommended. [less ▲]

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See detailEstablish data infrastructure to compile and exchange environmental screening data on a European scale
Slobodnik, Jaroslav; Hollender, Juliane; Schulze, Tobias et al

in Environmental Sciences Europe (2019), 31(1), 65

Robust techniques based on liquid (LC) and gas chromatography (GC) coupled with high-resolution mass spectrometry (HR-MS) enable sensitive screening, identification, and (semi)quantification of thousands ... [more ▼]

Robust techniques based on liquid (LC) and gas chromatography (GC) coupled with high-resolution mass spectrometry (HR-MS) enable sensitive screening, identification, and (semi)quantification of thousands of substances in a single sample. Recent progress in computational sciences has enabled archiving and processing of HR-MS ‘big data’ at the routine level. As a result, community-based databases containing thousands of environmental pollutants are rapidly growing and large databases of substances with unique identifiers allowing for inter-comparison at the global scale have become available. A data-archiving infrastructure is proposed, allowing for retrospective screening of HR-MS data, which will help define the ‘chemical universe’ of organic substances and enable prioritisation of toxicants causing adverse environmental effects at the local, river basin, and national and European scale in support of the European water and chemicals management policy. [less ▲]

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See detailMixed Reality - Potential and Pitfalls for Representing History
Botev, Jean UL

Presentation (2019)

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See detailOntology-based metabolomics data integration with quality control
Buendia, Patricia; Bradley, Ray M.; Taylor, Thomas J. et al

in Bioanalysis (2019), 11(12), 1139-1154

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See detailMt Sinai Special Seminar: Finding Small Molecules in Big Data
Schymanski, Emma UL

Presentation (2019)

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See detailChemInChIformatics: IUPAC's Role in the Environmental Monitoring Revolution
Schymanski, Emma UL

Scientific Conference (2019)

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See detail"Portante postmoderne"
Raus, Tonia UL

in De Toffoli, Ian; Millim, Anne-Marie (Eds.) Modernismes au Luxembourg. Traditions - Variations - Ruptures (2019)

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See detailCultural Factors Currently Affecting Inclusive Practice – Europe
Heck, Sandra UL; Fitzgerald, Hayley; Solenes, Oskar et al

in Heck, Sandra; Block, Martin (Eds.) Inclusive Physical Education around the World: Origins, Cultures, Practices (2019)

This chapter presents a brief comparison of inclusive practice in physical activity and education from four European national/regional perspectives – the United Kingdom, Germany, Italy and Norway ... [more ▼]

This chapter presents a brief comparison of inclusive practice in physical activity and education from four European national/regional perspectives – the United Kingdom, Germany, Italy and Norway/Scandinavia. The contributions are unified in as much as they suggest a common sense of purpose and philosophy; that difference should be recognized and welcomed and accommodation through changes in policy and practice put in place to ensure a broad and balanced physical education and sport experience for all young people. The UK section wrestles with the issue that terminology around inclusion has inhibited a clear direction but also emphasizes the significant role played by education in driving change. The section on Germany further reinforces the crucial importance of embedding inclusive practice in the education context but also highlights the variations in policy that can be endemic in a federal system. The Italy and Norway/Scandinavia contributions show how declarations agreed at international level can influence policy and affect practice on the ground in markedly different ways; in both, a focus on the needs of the individual is key. Whatever the approach, in all cases inclusion is primarily viewed as a fundamental human right. [less ▲]

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See detailEnvironmental Cheminformatics to Identify Unknown Chemicals and their Effects
Schymanski, Emma UL

Scientific Conference (2019)

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See detailIdentifying Small Molecules in Untargeted Exposomics Data: A case study of Thirdhand Smoke
Schymanski, Emma UL; Torres, Sonia; Ramirez, Noelia

Scientific Conference (2019)

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See detailBinding of iodinated contrast media (ICM) and their transformation products with hormone receptors: Are ICM the new EDCs?
Singh, Randolph UL; Rajnarayanan, Rajendram; Aga, Diana

in Science of the Total Environment (2019)

Iodinated contrast media (ICM) have been detected at high concentrations (as high as about 3 μg/L) in surface water systems, and recently in fish brains and gonad. The mismatch between the polarity of ICM ... [more ▼]

Iodinated contrast media (ICM) have been detected at high concentrations (as high as about 3 μg/L) in surface water systems, and recently in fish brains and gonad. The mismatch between the polarity of ICM and the high lipid content of brain raises questions on whether their bioaccumulation is receptor-mediated. Furthermore, the structural similarity of ICM to the natural thyroid hormones thyroxine and triiodothyronine suggest potential binding of ICM to nuclear receptors in the endocrine system. Therefore, an in silico approach based on Surflex-Dock module of SYBYL was used to investigate the molecular docking of selected ICM (diatrizoic acid, iohexol, iopamidol, and iopromide). These ICM showed interaction with nuclear receptors that play key roles in endocrine regulation, including the androgen and estrogen receptors. Furthermore, the results indicate peroxisome proliferator-activated receptor gamma (PPARg) as one of the viable targets in the endocrine disrupting potential of ICM with higher Cscores for the ICM and iopromide transformation products than the reference ligand for the receptor. The data obtained from in silico calculations showed stronger binding of iohexol to the transthyretin-binding pocket compared to the natural hormones, thyroxine and triiodothyronine, suggesting the potential of ICM to act as endocrine disrupting chemicals (EDCs) in the environment. [less ▲]

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See detailHistory of Inclusive Physical Education in Western and Northern Europe
Heck, Sandra UL; Solenes, Oskar; Magnanini, Angela et al

in Heck, Sandra; Block, Martin (Eds.) Inclusive Physical Education around the World: Origins, Cultures, Practices (2019)

Throwing a glance on the status quo in schools of different countries in Western and Northern Europe shows that the requirement of inclusive physical education (PE) is implemented different¬ly: Italy, for ... [more ▼]

Throwing a glance on the status quo in schools of different countries in Western and Northern Europe shows that the requirement of inclusive physical education (PE) is implemented different¬ly: Italy, for instance, leads the way with an almost complete inclusion of children into mainstream education including physical education (Magnanini & Espinosa, 2015), in Norway children have the right to follow mainstream education and one talks about “adjusted” education for pupils with special needs (Dalen 2006; Hyde, Ohna & Hjulstad, 2006), Germany is only slowly breaking up with its traditional system of segregating pupils with special needs (Hausotter & Pluhar, 2004). But what are those differences based on? How did inclusive physi¬¬cal education (PE) historically grow in England, Germany, Italy and Norway, and can trans¬national developments be identified? In all three chosen countries different school systems which are representative for other Northern and Western European countries exist. Aim of this study is to compare them, analyze their historical development and find out whether and in how far those differences in the school system and curricula development prejudged chances for inclusive PE and thereby led to diverse nowadays’ situations. As a result, it is confirmed that the educational policy towards inclusion in schools which was internationally determined to apply in different United Nation member states, finally met on the national level in Northern and Western Europe different conditions and social attitudes. This again led to the implementation of specific national inclusive and/or exclusive structures of PE in schools, which finally, despite the geographical proximity, deviate quite strongly, from each other, not only in terms of current content and policy but also in terms of historical development. [less ▲]

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See detailSWEMSA 2019: Finding Small Molecules in Big Data
Schymanski, Emma UL

Presentation (2019)

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See detailMicrobiota alter metabolism and mediate neurodevelopmental toxicity of 17β-estradiol
Catron, Tara R.; Swank, Adam; Wehmas, Leah C. et al

in Scientific Reports (2019), 9(1), 7064

Estrogenic chemicals are widespread environmental contaminants associated with diverse health and ecological effects. During early vertebrate development, estrogen receptor signaling is critical for many ... [more ▼]

Estrogenic chemicals are widespread environmental contaminants associated with diverse health and ecological effects. During early vertebrate development, estrogen receptor signaling is critical for many different physiologic responses, including nervous system function. Recently, host-associated microbiota have been shown to influence neurodevelopment. Here, we hypothesized that microbiota may biotransform exogenous 17-βestradiol (E2) and modify E2 effects on swimming behavior. Colonized zebrafish were continuously exposed to non-teratogenic E2 concentrations from 1 to 10 days post-fertilization (dpf). Changes in microbial composition and predicted metagenomic function were evaluated. Locomotor activity was assessed in colonized and axenic (microbe-free) zebrafish exposed to E2 using a standard light/dark behavioral assay. Zebrafish tissue was collected for chemistry analyses. While E2 exposure did not alter microbial composition or putative function, colonized E2-exposed larvae showed reduced locomotor activity in the light, in contrast to axenic E2-exposed larvae, which exhibited normal behavior. Measured E2 concentrations were significantly higher in axenic relative to colonized zebrafish. Integrated peak area for putative sulfonated and glucuronidated E2 metabolites showed a similar trend. These data demonstrate that E2 locomotor effects in the light phase are dependent on the presence of microbiota and suggest that microbiota influence chemical E2 toxicokinetics. More broadly, this work supports the concept that microbial colonization status may influence chemical toxicity. [less ▲]

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See detailUsing prepared mixtures of ToxCast chemicals to evaluate non-targeted analysis (NTA) method performance
Sobus, Jon R.; Grossman, Jarod N.; Chao, Alex et al

in Analytical and bioanalytical chemistry (2019), 411(4), 835-851

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See detailFrom 'Es war einmal' to 'Es war nicht': Batty Weber and the Poetry of Cemetaries in the 1910s
Millim, Anne-Marie UL

in Kmec, Sonja (Ed.) Ewige Ruhe? Concession à perpétuité? Grabkulturen in Luxemburg und den Nachbarregionen (2019)

This article hows that, during the 1910s, Weber establishes the cemetery as an indicator of cultural and societal health, capable of staging a process of healing that culminates in a liberating oblivion ... [more ▼]

This article hows that, during the 1910s, Weber establishes the cemetery as an indicator of cultural and societal health, capable of staging a process of healing that culminates in a liberating oblivion and consoling poetic reality. It also becomes a powerful tool to accentuate the absence of the graves of those who perished outside of the parameters that safeguard human dignity and is fundamental to Weber’s embedded critical political commentary. [less ▲]

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