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See detailLernstörungen im multilingualen Kontext: Diagnose und Hilfestellungen.
Ugen, Sonja UL; Schiltz, Christine UL; Fischbach, Antoine UL et al

Book published by Melusina Press (in press)

Um Kinder mit einer Lernstörung durch möglichst angepasste Hilfsmaßnahmen unterstützen zu können, ist eine umfassende Diagnostik maßgeblich. Die Diagnostik von Lernstörungen stellt vor allem in ... [more ▼]

Um Kinder mit einer Lernstörung durch möglichst angepasste Hilfsmaßnahmen unterstützen zu können, ist eine umfassende Diagnostik maßgeblich. Die Diagnostik von Lernstörungen stellt vor allem in multilingualen Kontexten - wie in Luxemburg - eine Herausforderung dar. Auch werden derzeit vorwiegend im Ausland entwickelte diagnostische Tests durchgeführt, welche die luxemburgischen Besonderheiten, wie etwa das Erlernen der schriftsprachlichen und mathematischen Kompetenzen in einer Zweit- oder Drittsprache, nicht berücksichtigen. Ausgehend vom aktuellen Forschungs- und Wissensstand wird ein vertieftes Verständnis im Hinblick auf Lese- und Rechtschreibstörungen und Rechenstörungen dargelegt. Darauf aufbauend werden diagnostische Vorgehensweisen sowie pädagogische Hilfsmaßnahmen mithilfe von Erfahrungswerten praktizierender Fachkräfte aus dem luxemburgischen Förderbereich vorgestellt. [less ▲]

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See detailGaussian Random Measures Generated by Berry's Nodal Sets
Peccati, Giovanni UL; Vidotto, Anna

in Journal of Statistical Physics (in press)

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See detailAdaptive Content Seeding for Information-Centric Networking under High Topology Dynamics
Turcanu, Ion UL; Engel, Thomas UL; Sommer, Christoph

in IEEE Vehicular Technology Magazine (in press)

High-fidelity content distribution and other emerging applications of 5G and beyond-5G mobile broadband networking can put massive load on the core and Radio Access Network (RAN). To address this, direct ... [more ▼]

High-fidelity content distribution and other emerging applications of 5G and beyond-5G mobile broadband networking can put massive load on the core and Radio Access Network (RAN). To address this, direct Device to Device (D2D) communication has recently become a first-class citizen of these networks. While Information-Centric Vehicular Networking (ICVN) based on fog computing can indeed exploit such D2D links to alleviate the load on the RAN by proactively seeding content in the network, it has been shown that such seeding can cause even more load if performed where not needed. In addition, trying to determine where to seed content often causes additional load, negating the benefit of seeding. In this work, we therefore propose to adaptively seed fog nodes based on a purely virtual clustering approach. Here, vehicles are unaware of clustering decisions, thus no longer requiring an explicit exchange of control messages. We show that the benefit of such an adaptive approach goes beyond simply being able to flexibly trade off performance metrics versus each other: instead, it can consistently lower the load on the RAN link. We also show that this property even holds if node location information is only available as coarsely-grained as macro-scale grid cells. [less ▲]

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See detailThe Measurement of Resilience
Asheim, Geir; Bossert, Walter; d'ambrosio, Conchita UL et al

in Journal of Economic Theory (in press)

Resilience has become an important topic in many social sciences. Numerous individual choices and economic and demographic outcomes are likely to be influenced by people’s resilience. School performance ... [more ▼]

Resilience has become an important topic in many social sciences. Numerous individual choices and economic and demographic outcomes are likely to be influenced by people’s resilience. School performance, work absenteeism and burnout, longevity, the quality of sleep and health-risk behaviors such as substance abuse are some examples. Similarly, it is of high policy relevance to understand the determinants of both individual resilience (such as educational, marital and occupational status) and ecological resilience (such as climate change). Empirical work designed to uncover such relationships suffers from the absence of a resilience measure applicable in the context of large data sets. We fill this gap by proposing a specific measure that is characterized by a set of natural properties. After an introduction to the notion of resilience and its attributes, we argue why these conditions have intuitive appeal. Finally, we provide illustrating examples and derive our main characterization result. [less ▲]

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See detailUpdate Internationales und Europäisches Steuerrecht
Sinnig, Julia UL

in Taeger, Jürgen (Ed.) Tagungsband DSRI-Herbstakademie 2020 (in press)

Im Berichtszeitraum dieses Updates rief die OECD zu einem zweiten Öffentlichkeitsbetei-ligungsverfahren auf und erarbeitete einen präziseren Lösungsansatz zur Besteuerung digitalisierter Geschäftsmodelle ... [more ▼]

Im Berichtszeitraum dieses Updates rief die OECD zu einem zweiten Öffentlichkeitsbetei-ligungsverfahren auf und erarbeitete einen präziseren Lösungsansatz zur Besteuerung digitalisierter Geschäftsmodelle, der in einer Veröffentlichung im Januar 2020 vorgestellt wurde. Auf Ebene der Europäischen Union gab es im Berichtszeitraum keine Weiterent-wicklung der Richtlinienvorschläge zu einer Digitalsteuer und dem Konzept der „signifi-kanten digitalen Präsenz“. Der EuGH urteilte am 3. März 2020 in Hinblick auf die unions-rechtliche Vereinbarkeit zweier ungarischer Umsatzsteuern. Dieses Urteil erlaubt erste Rückschlüsse bezüglich der Europarechtskonformität umsatzbasierter Steuern, wie bspw. auch im Berichtszeitraum eingeführte Digitalsteuern einzelner Mitgliedstaaten. Dieser Beitrag knüpft an die Vorträge von Prof. Dr. Jens M. Schmittmann und der Verfasserin anlässlich der Herbstakademien 2018 in Bochum und 2019 in Oldenburg, sowie dem Vortrag der Verfasserin anlässlich der Herbstakademie 2017 in Heidelberg an. [less ▲]

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See detailSelecting Fault Revealing Mutants
Titcheu Chekam, Thierry UL; Papadakis, Mike UL; Bissyande, Tegawendé François D Assise UL et al

in Empirical Software Engineering (in press)

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See detailJob Quality and Workplace Gender Diversity in Europe
Clark, Andrew; d'ambrosio, Conchita UL; Zhu, Rong

in Journal of Economic Behavior and Organization (in press)

We here consider the relationship between workplace gender measures and employees’ perceived job quality, where the former cover both the gender mix of workers with the same job title and the gender of ... [more ▼]

We here consider the relationship between workplace gender measures and employees’ perceived job quality, where the former cover both the gender mix of workers with the same job title and the gender of the immediate boss. Data from the 2015 European Working Conditions Survey show that men’s job evaluation is higher in gender-balanced job positions at the workplace, while that of women is higher in either gender-balanced or male-dominated positions. The gender of the immediate boss plays no significant role in employee job evaluation. There is some evidence that these correlations differ by job-quality domains. We introduce co-worker support and help, gender discrimination, and unwanted sexual attention as possible mediators of the gender-mix correlations: these change the estimated coefficients only little. Our estimated correlations could therefore reflect a pure preference for job-position gender composition. Last, we use a bounding approach to show that our main results are robust to the potential influence of unobservables. Overall, job-position gender diversity is associated with higher worker well-being. [less ▲]

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See detailA new synuclein-transgenic mouse model for early Parkinson's reveals molecular features of preclinical disease
Hendrickx, Diana M.; Garcia, Pierre; Ashrafi, Amer et al

in Molecular Neurobiology (in press)

Understanding Parkinson’s disease (PD) in particular in its earliest phases, is important for diagnosis and treatment. However, human brain samples are collected post- mortem, reflecting mainly end stage ... [more ▼]

Understanding Parkinson’s disease (PD) in particular in its earliest phases, is important for diagnosis and treatment. However, human brain samples are collected post- mortem, reflecting mainly end stage disease. Because brain samples of mouse models can be collected at any stage of the disease process, they are useful to investigate PD progression. Here, we compare ventral midbrain transcriptomics profiles from α- synuclein transgenic mice with a progressive, early PD-like striatal neurodegeneration across different ages using pathway, gene set and network analysis methods. Our study uncovers statistically significant altered genes across ages and between genotypes with known, suspected, or unknown function in PD pathogenesis and key pathways associated with disease progression. Among those are genotype-dependent alterations associated with synaptic plasticity, neurotransmission, as well as mitochondria-related genes and dysregulation of lipid metabolism. Age-dependent changes were among others observed in neuronal and synaptic activity, calcium homeostasis, and membrane receptor signaling pathways, many of which linked to G- protein coupled receptors. Most importantly, most changes occurred before neurodegeneration was detected in this model, which points to a sequence of gene expression events that may be relevant for disease initiation and progression. It is tempting to speculate that molecular changes similar to those changes observed in our model happen in midbrain dopaminergic neurons before they start to degenerate. In other words, we believe we have uncovered molecular changes that accompany the progression from preclinical to early PD. [less ▲]

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See detailDu mode bureaucratique vers l’agilité organisationnelle : le rôle de la communauté de pratique pilotée dans un établissement public
Obringer, Lisa Désirée UL; Geraudel, Mickaël UL; Benedic, Michael

in Projectique (in press)

Les établissements publics ont besoin de faire preuve d’agilité organisationnelle pour être performants et répondre aux nouveaux enjeux sociétaux. Cependant, ce besoin d’agilité est freiné par la logique ... [more ▼]

Les établissements publics ont besoin de faire preuve d’agilité organisationnelle pour être performants et répondre aux nouveaux enjeux sociétaux. Cependant, ce besoin d’agilité est freiné par la logique bureaucratique qui sous-tend le fonctionnement-même de ces établissements. Résoudre cette tension paradoxale entre bureaucratie et agilité organisationnelle requiert de mettre en œuvre le processus d’acceptation et de management de la tension paradoxale. Pour ce faire, la communauté de pratique pilotée offre un cadre d’analyse favorisant cette acceptation et donc le changement organisationnel souhaité. Ainsi, nous montrons, au travers d’une recherche action, comment la communauté de pratiques pilotée favorise le changement organisationnel au sein d’un établissement public luxembourgeois en facilitant sa transition d’une logique bureaucratique vers une logique d’agilité organisationnelle. Les implications sont doubles. Premièrement, nous montrons comment manager la tension entre bureaucratie et agilité au sein d’un établissement public. Deuxièmement, nous mettons en lumière le rôle de la communauté de pratique pilotée comme vecteur de changement organisationnel d’un établissement public. [less ▲]

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See detailThe degree of non-Galois Kummer extensions of number fields
Perucca, Antonella UL

in Rivista di Matematica della Universita di Parma (in press)

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See detailGBA variants in Parkinson’s disease: clinical, metabolomic and multimodal neuroimaging phenotypes
Greuel, Andrea; Trezzi, Jean-Pierre UL; Glaab, Enrico UL et al

in Movement Disorders (in press)

Background: Alterations in the GBA gene (NM_000157.3) are the most important genetic risk factor for Parkinson’s disease. Biallelic GBA mutations cause the lysosomal storage disorder Gaucher´s disease ... [more ▼]

Background: Alterations in the GBA gene (NM_000157.3) are the most important genetic risk factor for Parkinson’s disease. Biallelic GBA mutations cause the lysosomal storage disorder Gaucher´s disease. The GBA variants p.E365K and p.T408M are associated with Parkinson’s but not with Gaucher´s disease. The pathophysiological role of these variants needs to be further explored. Objective: This study analyzed the clinical, neuropsychological, metabolic and neuroimaging phenotypes of Parkinson’s disease patients carrying the GBA variants p.E365K and p.T408M. Methods: GBA was sequenced in 56 mid-stage Parkinson’s disease patients. Carriers of GBA variants were compared to non-carriers regarding clinical history and symptoms, neuropsychological features, metabolomics and multimodal neuroimaging. Blood plasma gas chromatography coupled to mass spectrometry, [18F]FDopa PET, [18F]FDG PET, and resting-state fMRI were performed. Results: Sequence analysis detected 13 heterozygous GBA variant carriers (seven with p.E365K, six with p.T408M). One patient carried a GBA mutation (p.N409S) and was excluded. Clinical history and symptoms were not significantly different between groups. Global cognitive performance was lower in variant carriers. Metabolomic group differences were suggestive of more severe Parkinson’s disease-related alterations in carriers versus non-carriers. [18F]FDopa and [18F]FDG PET showed signs of a more advanced disease; [18F]FDG PET and fMRI showed similarities with Lewy body dementia and Parkinson’s disease dementia in carriers. Conclusions: This is the first study to comprehensively assess (neuro-)biological phenotypes of GBA variants in Parkinson’s disease. Metabolomics and neuroimaging detected more significant group differences than clinical and behavioral evaluation. These alterations could be promising to monitor effects of disease-modifying treatments targeting glucocerebrosidase metabolism. [less ▲]

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See detailNoradrenergic activation induced by yohimbine decreases interoceptive accuracy in healthy individuals with childhood adversity
Schulz, André UL; Deuter, Christian E.; Breden, Ion-Hideo et al

in Development and Psychopathology (in press)

Acute stress affects interoception, but it remains unclear if this is due to activation of the sympatho-adreno-medullary (SAM) or hypothalamicpituitary-adrenocortical axis. This study aimed to investigate ... [more ▼]

Acute stress affects interoception, but it remains unclear if this is due to activation of the sympatho-adreno-medullary (SAM) or hypothalamicpituitary-adrenocortical axis. This study aimed to investigate the effect of SAM axis activation on interoceptive accuracy (IAcc). Central alpha2-adrenergic receptors represent a negative feedback mechanism of the SAM axis. Major depressive disorder and adverse childhood experiences (ACE) are associated with alterations in the biological stress systems, including central alpha2-adrenergic receptors. Here, healthy individuals with and without ACE as well as depressive patients with and without ACE (n=114; all without antidepressant medication) were tested after yohimbine (alpha2-adrenergic antagonist) and placebo. We assessed IAcc and sensibility in a heartbeat counting task. Increases in systolic and diastolic blood pressure after yohimbine confirmed successful SAM axis activation. IAcc decreased after yohimbine only in the healthy group with ACE, but remained unchanged in all other groups (‘group’ × ‘drug’ interaction). This effect may be due to selective up-regulation of alpha2-adrenergic receptors after childhood trauma, which reduces capacity for attention focus on heartbeats. The sympathetic neural pathway including alpha2-adrenergic circuitries may be essential for mediating interoceptive signal transmission. Suppressed processing of physical sensations in stressful situations may represent an adaptive response in healthy individuals who experienced ACE. [less ▲]

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See detailGene selection for optimal prediction of cell position in tissues from single-cell transcriptomics
Tanevski, Jovan; Nguyen, Thin; Truong, Buu et al

in Life Science Alliance (in press)

Single-cell RNA-seq (scRNAseq) technologies are rapidly evolving. While very informative, in standard scRNAseq experiments the spatial organization of the cells in the tissue of origin is lost. Conversely ... [more ▼]

Single-cell RNA-seq (scRNAseq) technologies are rapidly evolving. While very informative, in standard scRNAseq experiments the spatial organization of the cells in the tissue of origin is lost. Conversely, spatial RNA-seq technologies designed to maintain cell localization have limited throughput and gene coverage. Mapping scRNAseq to genes with spatial information increases coverage while providing spatial location. However, methods to perform such mapping have not yet been benchmarked. To fill this gap, we organized the DREAM Single-Cell Transcriptomics challenge focused on the spatial reconstruction of cells from the Drosophila embryo from scRNAseq data, leveraging as silver standard, genes with in situ hybridization data from the Berkeley Drosophila Transcription Network Project reference atlas. The 34 participating teams used diverse algorithms for gene selection and location prediction, while being able to correctly localize clusters of cells. Selection of predictor genes was essential for this task. Predictor genes showed a relatively high expression entropy, high spatial clustering and included prominent developmental genes such as gap and pair-rule genes and tissue markers. Application of the Top-10 methods to a zebrafish embryo dataset yielded similar performance and statistical properties of the selected genes than in the Drosophila data. This suggests that methods developed in this challenge are able to extract generalizable properties of genes that are useful to accurately reconstruct the spatial arrangement of cells in tissues. [less ▲]

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See detailLa technologie blockchain – et les tendances de la décorporéisation en droit et culture
Becker, Katrin UL

in Pistes. Revue de philosophie contemporaine. Éthique, politique, philosophie des techniques (in press), 1

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See detailIngeborg Bachmanns Simultan und die Frage der Rechtsbindung in Zeiten von Multilingualität und Transkulturalität
Becker, Katrin UL

in Walter, Tonio; Schramm, Edward (Eds.) Dichtung und Wahrheit - und Recht (in press)

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See detailHumanities als Rekonstrukteure des Rechts
Becker, Katrin UL

in the Ends of the Humanities (in press)

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See detailEfficient Preamble Detection and Time-of-Arrival Estimation for Single-Tone Frequency Hopping Random Access in NB-IoT
Chougrani, Houcine UL; Kisseleff, Steven UL; Chatzinotas, Symeon UL

in IEEE Internet of Things Journal (in press)

The narrowband internet of things (NB-IoT) standard is a new cellular wireless technology, which has been introduced by the 3rd Generation Partnership Project (3GPP) with the goal to connect massive low ... [more ▼]

The narrowband internet of things (NB-IoT) standard is a new cellular wireless technology, which has been introduced by the 3rd Generation Partnership Project (3GPP) with the goal to connect massive low-cost, low-complexity and long-life IoT devices with extended coverage. In order to improve power efficiency, 3GPP proposed a new Random Access (RA) waveform for NB-IoT based on a single-tone frequencyhopping scheme. RA handles the first connection between user equipments (UEs) and the base station (BS). Through this, UEs can be identified and synchronized with the BS. In this context, receiver methods for the detection of the new waveform should satisfy the requirements on the successful user detection as well as the timing synchronization accuracy. This is not a trivial task, especially in the presence of radio impairments like carrier frequency offset (CFO) which constitutes one of the main radio impairments besides the noise. In order to tackle this problem, we propose a new receiver method for NB-IoT Physical Random Access Channel (NPRACH). The method is designed to eliminate perfectly the CFO without any additional computational complexity and supports all NPRACH preamble formats. The associated performance has been evaluated under 3GPP conditions. We observe a very high performance compared both to 3GPP requirements and to the existing state-of-the-art methods in terms of detection accuracy and complexity. [less ▲]

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See detailWhich Properties has an Icon? A Critical Discussion on Evaluation Methods for Standardised Data Protection Iconography
Rossi, Arianna UL; Lenzini, Gabriele UL

in Proceedings of the 8th Workshop on Socio-Technical Aspects in Security and Trust (STAST) (in press)

Following GDPR's Article12.7's proposal to use standardized icons to inform data subject in "an easily visible, intelligible and clearly legible manner," several icon sets have been developed. In this ... [more ▼]

Following GDPR's Article12.7's proposal to use standardized icons to inform data subject in "an easily visible, intelligible and clearly legible manner," several icon sets have been developed. In this paper, we firstly critically review some of those proposals. We then examine the properties that icons and icon sets should arguably fulfill according to Art.12's transparency provisions. Lastly, we discuss metrics and evaluation procedures to measure compliance with the Article. [less ▲]

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See detailCognitive processes underlying impaired decision-making in gambling disorder.
Brevers, Damien UL; Vögele, Claus UL; Billieux, Joël

in Zaleskiewicz, Thomas (Ed.) Psychological Perspectives on Financial Decision Making. (in press)

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