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See detailThe Virtual Metabolic Human database: integrating human and gut microbiome metabolism with nutrition and disease
Noronha, Alberto UL; Modamio Chamarro, Jennifer UL; Jarosz, Yohan UL et al

in Nucleic Acids Research (2018)

A multitude of factors contribute to complex diseases and can be measured with ‘omics’ methods. Databases facilitate data interpretation for underlying mechanisms. Here, we describe the Virtual Metabolic ... [more ▼]

A multitude of factors contribute to complex diseases and can be measured with ‘omics’ methods. Databases facilitate data interpretation for underlying mechanisms. Here, we describe the Virtual Metabolic Human (VMH, www.vmh.life) database encapsulating current knowledge of human metabolism within five interlinked resources ‘Human metabolism’, ‘Gut microbiome’, ‘Disease’, ‘Nutrition’, and ‘ReconMaps’. The VMH captures 5180 unique metabolites, 17 730 unique reactions, 3695 human genes, 255 Mendelian diseases, 818 microbes, 632 685 microbial genes and 8790 food items. The VMH’s unique features are (i) the hosting of the metabolic reconstructions of human and gut microbes amenable for metabolic modeling; (ii) seven human metabolic maps for data visualization; (iii) a nutrition designer; (iv) a user-friendly webpage and application-programming interface to access its content; (v) user feedback option for community engagement and (vi) the connection of its entities to 57 other web resources. The VMH represents a novel, interdisciplinary database for data interpretation and hypothesis generation to the biomedical community. [less ▲]

Detailed reference viewed: 289 (30 UL)
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See detailMosaic Trisomy 21/Monosomy 21 in a Living Female Infant
Nguyen, HP; Riess, A; Krüger, Maren UL et al

in Cytogenetic and Genome Research (2009), 125(1), 26-32

Detailed reference viewed: 124 (4 UL)
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See detailRadioresistance of K-Ras mutated human tumor cells is mediated through EGFR-dependent activation of PI3K-AKT pathway
Toulany, M; Dittmann, K; Krüger, Maren UL et al

in Radiotherapy and Oncology (2005), 76(2), 143-150

Detailed reference viewed: 111 (2 UL)
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See detailExclusion of the C/D box snoRNA gene cluster HBII-52 from a major role in Prader–Willi syndrome
Runte, Maren UL; Varon, R; Horn, D et al

in Human Genetics (2005), 116(3), 228-230

Detailed reference viewed: 97 (0 UL)
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See detailSNURF-SNRPN and UBE3A transcript levels in patients with Angelman syndrome
Runte, Maren UL; Kroisel, PM; Gillessen-Kaesbach, G et al

in Human Genetics (2004), 114(6), 553-561

Detailed reference viewed: 94 (0 UL)
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See detailThe IC-SNURF–SNRPN transcript serves as a host for multiple small nucleolar RNA species and as an antisense RNA for UBE3A
Runte, Maren UL; Huettenhofer, A; Groß, S et al

in Human Molecular Genetics (2001), 10(23), 2687-2700

Detailed reference viewed: 105 (0 UL)
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See detailComprehensive methylation analysis in typical and atypical PWS and AS patients with normal biparental chromosomes 15
Runte, Maren UL; Faerber, Claudia; Lich, Christina et al

in European Journal of Human Genetics (2001), 9(7), 519-526

Detailed reference viewed: 92 (2 UL)
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See detailEvaluation of RDS/Peripherin and ROM1 as candidate genes in generalised progressive retinal atrophy and exclusion of digenic inheritance
Runte, Maren UL; Dekomien, Gabriele; Epplen, Jörg T

in Animal Genetics (2000), 31(3), 223-227

Detailed reference viewed: 101 (1 UL)
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See detailGeneralized progressive retinal atrophy of Sloughi dogs is due to an 8-bp insertion in exon 21 of the PDE6B gene
Dekomien, Gabriele; Runte, Maren UL; Goedde, René et al

in CytoGenetics and Cell Genetics (2000), 90(3-4), 261-267

Detailed reference viewed: 163 (2 UL)
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See detailThe IL-10 gene is not involved in the predisposition to inflammatory bowel disease.
Klein, Wolfram; Tromm, Andreas; Griga, Thomas et al

in Electrophoresis (2000), 21(17), 3578-3582

Detailed reference viewed: 102 (1 UL)