Etude de differentes methodes pour la mise en evidence des autoanticorps anti-glutamate-decarboxylase associes au developpement du diabete insulinodependant
Humbel, R. L.; Guillaume, A. C.; Schmit, P.et al.
1997 • In Immuno-Analyse et Biologie Specialisee, 12 (5), p. 275-279
[en] Autoantibodies to glutamate-decarboxylase (GAD) are present in the serum of patients with insulin dependent diabetes (DID) even before the development of the overt diabetes. These antibodies react predominantly with the native GAD. Various methods have been studied (radio immunoassay [RIA] and enzyme- linked immunosorbent assay [ELISA]). It was observed that at the present time only RIA-tests, in which GAD is presented in fluid phase, are able to detect antibodies.
Disciplines :
Human health sciences: Multidisciplinary, general & others
Identifiers :
eid=2-s2.0-0030689611
Author, co-author :
Humbel, R. L.; Laboratoire d'Immunopathologie, Centre Hospitalier de Luxembourg, 4, rue Barblé, Ll210 Luxembourg, Luxembourg
Guillaume, A. C.; Laboratoire d'Immunopathologie, Centre Hospitalier de Luxembourg, 4, rue Barblé, Ll210 Luxembourg, Luxembourg
Schmit, P.; Laboratoire d'Immunopathologie, Centre Hospitalier de Luxembourg, 4, rue Barblé, Ll210 Luxembourg, Luxembourg
Gilson, G.; Laboratoire d'Immunopathologie, Centre Hospitalier de Luxembourg, 4, rue Barblé, Ll210 Luxembourg, Luxembourg
De Beaufort, Carine ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Michel, G.; Epidip-CRP-Study Group, Centre Hospitalier de Luxembourg, 4, rue Barblé, Ll210 Luxembourg, Luxembourg
Mauch, L.; Elias Entwicklungslabor, Elias, Freiburg, Germany
External co-authors :
yes
Language :
French
Title :
Etude de differentes methodes pour la mise en evidence des autoanticorps anti-glutamate-decarboxylase associes au developpement du diabete insulinodependant
Alternative titles :
[en] A comparative study of assays used for the detection of glutamic acid decarboxylase autoantibodies and their relevance in the follow-up of insulin- dependent diabetes
