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Article (Scientific journals)
The genetic and regulatory architecture of ERBB3-type 1 diabetes susceptibility locus
Kaur, S.; Mirza, A. H.; Brorsson, C. A. et al.
2016 • In Molecular and Cellular Endocrinology, 419, p. 83-91
Peer reviewed
Permalink
https://hdl.handle.net/10993/27173
DOI
10.1016/j.mce.2015.10.002
PubMed
26450151
 

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Keywords :
Apoptosis; Beta cell; CTCF; ERBB3; LncRNAs; Type 1 diabetes; Article; B lymphocyte; ERBB3 gene
Abstract :
[en] The study aimed to explore the role of ERBB3 in type 1 diabetes (T1D). We examined whether genetic variation of ERBB3 (rs2292239) affects residual β-cell function in T1D cases. Furthermore, we examined the expression of ERBB3 in human islets, the effect of ERBB3 knockdown on apoptosis in insulin-producing INS-1E cells and the genetic and regulatory architecture of the ERBB3 locus to provide insights to how rs2292239 may confer disease susceptibility. rs2292239 strongly correlated with residual β-cell function and metabolic control in children with T1D. ERBB3 locus associated lncRNA (NONHSAG011351) was found to be expressed in human islets. ERBB3 was expressed and down-regulated by pro-inflammatory cytokines in human islets and INS-1E cells; knockdown of ERBB3 in INS-1E cells decreased basal and cytokine-induced apoptosis. Our data suggests an important functional role of ERBB3 and its potential regulators in the β-cells and may constitute novel targets to prevent β-cell destruction in T1D. © 2015 Elsevier Ireland Ltd.
Disciplines :
Human health sciences: Multidisciplinary, general & others
Identifiers :
eid=2-s2.0-84949729662
Author, co-author :
Kaur, S.;  Copenhagen Diabetes Research Center (CPH-DIRECT), Department of Pediatrics, Herlev University Hospital, Herlev Ringvej 75, Herlev, Denmark, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark
Mirza, A. H.;  Copenhagen Diabetes Research Center (CPH-DIRECT), Department of Pediatrics, Herlev University Hospital, Herlev Ringvej 75, Herlev, Denmark, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark, Center for Non-coding RNA in Technology and Health, University of Copenhagen, Denmark
Brorsson, C. A.;  Copenhagen Diabetes Research Center (CPH-DIRECT), Department of Pediatrics, Herlev University Hospital, Herlev Ringvej 75, Herlev, Denmark
Fløyel, T.;  Copenhagen Diabetes Research Center (CPH-DIRECT), Department of Pediatrics, Herlev University Hospital, Herlev Ringvej 75, Herlev, Denmark
Størling, J.;  Copenhagen Diabetes Research Center (CPH-DIRECT), Department of Pediatrics, Herlev University Hospital, Herlev Ringvej 75, Herlev, Denmark
Mortensen, H. B.;  Copenhagen Diabetes Research Center (CPH-DIRECT), Department of Pediatrics, Herlev University Hospital, Herlev Ringvej 75, Herlev, Denmark, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark
Pociot, F.;  Copenhagen Diabetes Research Center (CPH-DIRECT), Department of Pediatrics, Herlev University Hospital, Herlev Ringvej 75, Herlev, Denmark, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark, Center for Non-coding RNA in Technology and Health, University of Copenhagen, Denmark
Aanstoot, H.-J.;  Center for Pediatric and Adolescent Diabetes Care and Research, Rotterdam, Netherlands
De Beaufort, Carine ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Cameron, F.;  Department of Endocrinology and Diabetes, Royal Children's Hospital, Parkville, VIC, Australia
Castano, L.;  Endocrinology and Diabetes Research Group, Hospital de Cruces, University of Basque Country, Barakaldo, Spain
Dorchy, H.;  Diabetology Clinic, University Hospital Reine Fabiola, Brussels, Belgium
Fisher, L.;  Department of Endocrinology and Diabetes Children's Hospital of Los Angeles, Los Angeles, CA, United States
Kaprio, E.;  Department of Paediatrics, Peijas Hospital, HUS, Finland
Lange, K.;  Department of Medical Psychology, Hannover Medical School, Hannover, Germany
Neu, A.;  Clinic for Children and Adolescence, University of Tuebingen, Tuebingen, Germany
Njolstad, P. R.;  Department of Clinical Medicine University of Bergen, Bergen, Norway, Department of Paediatrics, Haukeland University Hospital, Bergen, Norway
Phillip, M.;  National Center of Childhood Diabetes, Schneiders Medical Center of Israel, Petah Tikva, Israel
Urukami, T.;  School of Medicine, Nihon University, Tokyo, Japan
Barrett, T.;  Institute of Child Health and Birmingham Children's Hospital, University of Birmingham, Birmingham, United Kingdom
Chiarelli, F.;  Clinica Pediatrica, Ospedale Policlinico, Chieti, Italy
Danne, T.;  Kinderkrankenhaus auf der Bult, Hannover, Germany
Hoey, H.;  University of Dublin, National Children's Hospital, Tallaght, Ireland
Kocova, M.;  Pediatric Clinic-Skopje, Macedonia
Mortensen, B.;  Department of Pediatrics, Herlev Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Denmark
Schoenle, J.;  University Children's Hospital, Zurich, Switzerland
Swift, G. F.;  Leicester Royal Infirmary Childrens Hospital, Leicester, United Kingdom
Vanelli, M.;  Clinica Pediatrica, Centro di Diabetologia, Parma, Italy
Åman, J.;  Örebro Medical Centre Hospital, Department of Paediatrics, Sweden
Robert, J.J.
More authors (20 more) Less
External co-authors :
yes
Language :
English
Title :
The genetic and regulatory architecture of ERBB3-type 1 diabetes susceptibility locus
Publication date :
2016
Journal title :
Molecular and Cellular Endocrinology
ISSN :
0303-7207
Publisher :
Elsevier Ireland Ltd
Volume :
419
Pages :
83-91
Peer reviewed :
Peer reviewed
Available on ORBilu :
since 14 May 2016

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