References of "Doctoral thesis"      in Complete repository Arts & humanities   Archaeology   Art & art history   Classical & oriental studies   History   Languages & linguistics   Literature   Performing arts   Philosophy & ethics   Religion & theology   Multidisciplinary, general & others Business & economic sciences   Accounting & auditing   Production, distribution & supply chain management   Finance   General management & organizational theory   Human resources management   Management information systems   Marketing   Strategy & innovation   Quantitative methods in economics & management   General economics & history of economic thought   International economics   Macroeconomics & monetary economics   Microeconomics   Economic systems & public economics   Social economics   Special economic topics (health, labor, transportation…)   Multidisciplinary, general & others Engineering, computing & technology   Aerospace & aeronautics engineering   Architecture   Chemical engineering   Civil engineering   Computer science   Electrical & electronics engineering   Energy   Geological, petroleum & mining engineering   Materials science & engineering   Mechanical engineering   Multidisciplinary, general & others Human health sciences   Alternative medicine   Anesthesia & intensive care   Cardiovascular & respiratory systems   Dentistry & oral medicine   Dermatology   Endocrinology, metabolism & nutrition   Forensic medicine   Gastroenterology & hepatology   General & internal medicine   Geriatrics   Hematology   Immunology & infectious disease   Laboratory medicine & medical technology   Neurology   Oncology   Ophthalmology   Orthopedics, rehabilitation & sports medicine   Otolaryngology   Pediatrics   Pharmacy, pharmacology & toxicology   Psychiatry   Public health, health care sciences & services   Radiology, nuclear medicine & imaging   Reproductive medicine (gynecology, andrology, obstetrics)   Rheumatology   Surgery   Urology & nephrology   Multidisciplinary, general & others Law, criminology & political science   Civil law   Criminal law & procedure   Criminology   Economic & commercial law   European & international law   Judicial law   Metalaw, Roman law, history of law & comparative law   Political science, public administration & international relations   Public law   Social law   Tax law   Multidisciplinary, general & others Life sciences   Agriculture & agronomy   Anatomy (cytology, histology, embryology...) & physiology   Animal production & animal husbandry   Aquatic sciences & oceanology   Biochemistry, biophysics & molecular biology   Biotechnology   Entomology & pest control   Environmental sciences & ecology   Food science   Genetics & genetic processes   Microbiology   Phytobiology (plant sciences, forestry, mycology...)   Veterinary medicine & animal health   Zoology   Multidisciplinary, general & others Physical, chemical, mathematical & earth Sciences   Chemistry   Earth sciences & physical geography   Mathematics   Physics   Space science, astronomy & astrophysics   Multidisciplinary, general & others Social & behavioral sciences, psychology   Animal psychology, ethology & psychobiology   Anthropology   Communication & mass media   Education & instruction   Human geography & demography   Library & information sciences   Neurosciences & behavior   Regional & inter-regional studies   Social work & social policy   Sociology & social sciences   Social, industrial & organizational psychology   Theoretical & cognitive psychology   Treatment & clinical psychology   Multidisciplinary, general & others     Showing results 601 to 700 of 1187     2 3 4 5 6 7 8 9 10 11 12     IDENTITÄTSKONSTRUKTIONEN UND NATIONENBILDER IN LUXEMBURG IM SPIEGEL VON LITERATUR UND MEDIENBaumann, Isabell Doctoral thesis (2015)Detailed reference viewed: 109 (25 UL) Zur Geschichte und Entwicklung der Militär- und der Amateurblasmusik im Musikkreis SaarlouisJakobs, Björn Doctoral thesis (2015)Detailed reference viewed: 74 (15 UL) Challenges and Outlook in Machine Learning-based Malware Detection for AndroidAllix, Kevin Doctoral thesis (2015)Just like in traditional desktop computing, one of the major security issues in mobile computing lies in malicious software. Several recent studies have shown that Android, as today’s most widespread ... [more ▼]Just like in traditional desktop computing, one of the major security issues in mobile computing lies in malicious software. Several recent studies have shown that Android, as today’s most widespread Operating System, is the target of most of the new families of malware. Manually analysing an Android application to determine whether it is malicious or not is a time- consuming process. Furthermore, because of the complexity of analysing an application, this task can only be conducted by highly-skilled—hence hard to come by—professionals. Researchers naturally sought to transfer this process from humans to computers to lower the cost of detecting malware. Machine-Learning techniques, looking at patterns amongst known malware and inferring models of what discriminates malware from goodware, have long been summoned to build malware detectors. The vast quantity of data involved in malware detection, added to the fact that we do not know a priori how to express in technical terms the difference between malware and goodware, indeed makes the malware detection question a seemingly textbook example of a possible Machine- Learning application. Despite the vast amount of literature published on the topic of detecting malware with machine- learning, malware detection is not a solved problem. In this Thesis, we investigate issues that affect performance evaluation and that thus may render current machine learning-based mal- ware detectors for Android hardly usable in practical settings, and we propose an approach to overcome those issues. While the experiments presented in this thesis all rely on feature-sets obtained through lightweight static analysis, several of our findings could apply equally to all Machine Learning-based malware detection approaches. In the first part of this thesis, background information on machine-learning and on malware detection is provided, and the related work is described. A snapshot of the malware landscape in Android application markets is then presented. The second part discusses three pitfalls hindering the evaluation of malware detectors. We show with extensive experiments how validation methodology, History-unaware dataset construction and the choice of a ground truth can heavily interfere with the performance results of malware detectors. In a third part, we present an practical approach to detect Android Malware in real-world settings. We then propose several research paths to get closer to our long term goal of building practical, dependable and predictable Android Malware detectors. [less ▲]Detailed reference viewed: 294 (31 UL) Autonomie – Metaphysik – Endlichkeit: Die Endlichkeit menschlichen Denkens bei KantGunkel, Alexander Jürgen Doctoral thesis (2015)It is often maintained that German Enlightenment philosophy—and especially the Enlightenment program that Immanuel Kant articulated in his famous article in the Berlinische Monatsschrift—is not able to do ... [more ▼]It is often maintained that German Enlightenment philosophy—and especially the Enlightenment program that Immanuel Kant articulated in his famous article in the Berlinische Monatsschrift—is not able to do justice to the role of testimonial knowledge and hence is an obstacle to a down-to-earth epistemology because of its essential individualistic stance. I argue that this is a misunderstanding and that Kant like other Enlightenment thinkers actually recognizes these social factors and their impact on our knowing and thinking. I show that Kant's philosophy can be reconstructed as an attempt to show the compatibility of Enlightenment's demand for independence and the essential dependency of finite cognizers. His mature philosophy aims at developing a kind of Enlightenment Ethics of Belief that can be found in the final sections of his Critique of Pure Reason. The central task of (a Kantian conception of) Enlightenment points to intellectual independence, the thinking for oneself and the spontaneous activity of our own intellectual faculties that is not ruled by others but only by ourselves. Now this activity should consist of the actualization of the common faculty of reason and not in arbitrary decision making to believe one thing over another. Thinking for oneself thus seems to be the outcome of a competence rather than the result of a mere decision. This is an insight which was famously defended by Christian Wolff. While Wolff claims that this competence is to be understood as being able to follow some special method—the mathematical method—Kant points to the social character of thinking. Thinking for oneself means competently reasoning in accordance with rules that can only be followed and assessed through conversational practice. How is this demand for maturity affected by our finiteness? To answer this question it is necessary to give a clear concept of our finiteness. According to Kant, the core of our finiteness as human beings consists in our dependency on being passively affected: on cognizing things with our senses instead of through pure reason or by what we are told. We cannot cognize things without being affected by them; all that we know by pure reason alone are very general truths (for instance, things happen in accordance to natural laws). The terminus technicus for this concept is discursivity which is the property of concepts that distinguishes them from intuitions. A concept is a representation that is discursive which means that it is mediately related to its objects via universal marks and is hence a universal representation. Intuitions on the other hand are immediately related to their objects and are hence singular representations. Our understanding is discursive because it is a faculty of thinking which cognizes objects through concepts that are dependent on a faculty of intuitions to relate to objects. Without such intuitive, i.e., immediate relations our understanding would have no content at all. Most work on testimonial knowledge focuses on the trustworthiness and competence of the speaker. Although Kant addresses such topics, these are rather secondary reflections unsuited to be an adequate foundation for understanding of the compatibility of intellectual independence and the dependency on others. In freely following Wolff, Kant distinguishes in a first step between rational and historical cognitions. A cognition is rational if it is generated by the cognizer's own use of his pure reason, otherwise it is historical, i.e. it is given to him by his senses or the words of others. In a second step he makes a difference between rational and empirical cognitions, the latter being cognitions that can only be known historically. While the distinction between rational and empirical cognitions signifies a difference in their very character, the difference between rational and historical cognitions means a difference in our own personal access to them. (In a further step he distinguishes between discursive rational cognitions in philosophy and intuitive rational cognitions in mathematics, but this is of lesser importance than the first distinction.) The point is that different kinds of cognitions are to be treated in different ways. Having a critical stance toward testimonial knowledge means that we should not accept rational cognitions on the grounds of being told. Knowingly diverging from his predecessors, Kant defines metaphysics as the system of rational cognitions, i.e. the systematically ordered body of knowledge we gained through pure reason. Thus metaphysics is the discipline that does not allow for just historical cognitions. Now to Kant philosophy is not—as it has been for Wolff and others—the whole body of science besides mathematics, but is rather identical with metaphysics. Summarizing all these results we can assign a reason for why we should learn philosophizing rather than philosophy: It is because metaphysics is a rational discipline that we cannot learn by acquiring merely historical knowledge but only by learning to use our own faculty of reason. [less ▲]Detailed reference viewed: 196 (14 UL) LEGAL CHALLENGES FACING CLOUD COMPUTING – A STUDY OF RELEVANT CONCEPTS IN CURRENT AND FUTURE EU DATA PROTECTION LAWGniewek, Alicja Doctoral thesis (2015)Detailed reference viewed: 165 (18 UL) Domain-general versus Domain-specific Approach of Creativity: Arts, Science and Everyday LifeKirsch, Christiane Doctoral thesis (2015)The investigation of domain-specificity by means of structural models is undoubtedly one of the most contemporary subjects in creativity research. Whilst the dominant approach conceives creativity as a ... [more ▼]The investigation of domain-specificity by means of structural models is undoubtedly one of the most contemporary subjects in creativity research. Whilst the dominant approach conceives creativity as a relatively general mental capacity, a more recent, and relatively underexplored approach, conceives creativity as domain-specific. Three major domains of creative expression are often distinguished: arts, science and everyday life (Batey & Furnham, 2006). The hybrid approach reconciles to some extent the domain-general and domain-specific paradigm, by allowing for domain-general, domain-specific and even task specific features (Lubart & Guignard, 2004). The present research explored this differential approach, which raises the question, in how far the cognitive and conative creative profiles, can be generalized. These were investigated in the domains of arts, science and everyday life. The artistic creative profile of architects was compared to the scientific creative profile of psychologists and the everyday creative profile of the general population. With this in mind the three test groups (architects, psychologists, general population), were subjected to a general creativity test. One population-specific creativity test was added within every sample. The differential approach of creativity, integrating both domain-general and domain-specific features, was confirmed. This doctoral dissertation allows for different creative profiles with regard to specific domains of creative expression to be established. It became clear that architects demonstrated the expected profile for scientific creativity, whilst psychologists demonstrated the expected profile for artistic creativity. As anticipated, the everyday creative profile was presented by people of the general population. It was characterized by openness to new experiences and, to a lesser extent, by intelligence. Presently, the image of the psychologically conflicted architect, sometimes projected by the literature (Barron, 1965, 1969; MacKinnon, 1961, 1962), could not be confirmed. This image was further associated with creative psychologists. Implications and limits of these results are discussed further below. [less ▲]Detailed reference viewed: 157 (9 UL) Intersektionalität und Gouvernementalität. Die Problematisierung der Prostitution in Luxemburg um 1900 bis zum Ende der ZwischenkriegszeitMauer, Heike Doctoral thesis (2015)My dissertation “Intersektionalität und Gouvernementalität. Die Problematisierung der Prostitution in Luxemburg um 1900 bis zum Ende der Zwischenkriegszeit” pursues three scientific aims: first it ... [more ▼]My dissertation “Intersektionalität und Gouvernementalität. Die Problematisierung der Prostitution in Luxemburg um 1900 bis zum Ende der Zwischenkriegszeit” pursues three scientific aims: first it advances political and feminist theory, secondly it contributes to Luxembourgian social, political and gender history by developing thirdly a fresh methodology. The object of investigation is the historical problematization of prostitution in Luxembourg – that is the perception and 'government' of prostitution as a problem of societal and individual moral conduct. My thesis is the first major historical publication, dedicated to the analysis of prostitution in Luxembourg. The main research question pursued was to identify the intersectional dimensions of this problematization of prostitution and to identify its inherent logics of power. The innovative, theory-driven method used for investigation rested on the connection of two theoretical concepts: intersectionality (a tool to understand gender as always related to other dimensions of power and inequality such as class, race, nation, citizenship, etc.) and governmentality (a distinct mode of power, which is - unlike sovereignty or discipline – characterized by the capacity to govern the conduct of others as well as by “technologies of the self” [Foucault]). By developing this methodology, my thesis also advances political and feminist theory. I highlight actual shortfalls of intersectional approaches and strengthen the tools analytical capacities to investigate power relations. I developed an understanding of intersectionality focusing on the processes and modes of how power is exercised, transcending static approaches, which perceive intersectionality solely in terms of inequalities. Empiricaly I demonstrated, that power was exercised intersectionally through the problematization of prostitution, while the problematization adressed different intersectional subjects differently: the prostitute was identified by a logic of suspicion as a poor foreign woman, who was deported in order to 'morally cleanse' the nation. Through the government of moral conduct, Luxembourgian working class women were encouraged to be good housewives in order to prevent their husbands from falling for prostitution in bars. [less ▲]Detailed reference viewed: 141 (17 UL) Patient-derived colon cancer stem cell-like spheroid cultures-characterization and effect of hypoxiaBaig, Komal Doctoral thesis (2015)Detailed reference viewed: 222 (42 UL) Biopharm - the Influence of Macro-substrates & Conditioning on Pharmaceutical Removal Rates by Moving Bed Biofilm ReactorsKöhler, Christian Doctoral thesis (2015)Organic micropollutants with endocrine disruptive properties are present in the aquatic environment. A major part of their emission is caused by municipal wastewater treatment plants (WWTPs). For this ... [more ▼]Organic micropollutants with endocrine disruptive properties are present in the aquatic environment. A major part of their emission is caused by municipal wastewater treatment plants (WWTPs). For this reason, a vast amount of research has been undertaken to remove xenobiotics from municipal wastewater by developing post-treatment technologies with some success. However, these technologies cause considerable environmental costs due their high demand for electrical energy implicating an increase in CO2 emissions. Consequently, existing biological treatments need first to be better understood and subsequently optimized regarding xenobiotic removal before post-treatments are employed. The study focused on the fate of xenobiotics during biological wastewater treatment. In particular, metabolic strategies of bacteria degrading pharmaceuticals were investigated within moving bed biofilm reactor (MBBR) processes. Two main objectives were tracked. On the one hand, it was to unfold the impact of macro-substrates in terms of type and molecular complexity on the activity of microorganisms and consequently pharmaceutical degradation performance. On the other hand, the study was set out to explore the adaptation of metabolic means regarding exoenzymes and consortia structure during continuous (long-term) exposure to pharmaceuticals. Accordingly, the ability to increase microbial competences during pharmaceutical short-term pulses was the general target of investigation. Both conditions continuous substance flow and short-term peak loads of xenobiotics are believed to occur in urban WWTPs. A pilot MBBR was set up next to a domestic WWTP. The pilot treated municipal sewage and served as inoculation reservoir for biofilm carriers used for in-depth laboratory experiments. The latter comprised six lab-scale MBBRs featuring flow through operation under controlled conditions regarding temperature, dissolved oxygen, pH, influent flow and influent load. The reactors were conditioned over four weeks with a synthetic sewage providing substrates and micro-nutrients in a similar manner as expected under real conditions. Biofilm was monitored by respirometry and a series of enzyme assays using fluorogenic substrates to capture esterase, phosphatase, alpha- and beta-glucosidase and aminopeptidase activity. All enzymes are essential during organic carbon metabolism. An array of macro-substrates with different molecular complexity was triggering individual enzyme activity profiles. After conditioning, 12 pharmaceuticals being subject to a range of anticipated metabolic pathways and degradation rates were spiked into the MBBRs. Their degradation kinetics were measured by liquid chromatography coupled with tandem mass spectrometry (LC MS/MS). Pseudo first-order kinetics revealed substrate related fingerprints and showed that readily biodegradable substrate leads generally to good pharmaceutical degradation performance compared to synthetic sewage with a mixture of several high molecular organic substrates. The latter was designed to induce the greatest metabolic effort of tested substrates before microbial uptake occurs. However, single substrates triggering exoenzyme activity in a more targeted manner such as maltose and cellobiose showed positive impact on the pseudo first-order rate coefficients of particular pharmaceuticals such as atenolol and diclofenac. Accordingly, alpha-glucosidase activity was found to be directly proportional to atenolol degradation kinetics. Phylogenetic characterisation of DNA and RNA involving state-of-the-art 16S ribosomal rRNA gene amplification and sequencing techniques was used to explore community structures. Prokaryote diversity in lab-scale MBBRs was in agreement to previous studies which investigated microbial consortia in full-scale systems. Multivariate analysis revealed that bacteria are adapting their active gene pool when the beta-blocker atenolol is continuously present with a concentration in ug/L range. Differential analysis unfolded that the prokaryotic genera Delftia and Lysobacter were thereby exclusively benefiting from the exposure to atenolol. Yet, compared to the influence of macro-substrates, biomass conditioning (training) with atenolol and diclofenac had no notable impact on the degradation performance of pharmaceutical short-term pulses. The outstanding comprehensive character of the study which encompassed sophisticated experimental design and powerful analytical tools from different scientific domains uncovered some interesting insights in xenobiotic degradation processes. The results finally show how biomass is reacting towards the presence of primary carbon sources and organic micro-pollutants. The outcomes highlight the importance of WWTP influent characterization being indicative of metabolic activity and therefore degradation capacity of xenobiotics. The study further suggests that xenobiotic metabolism and co-metabolism co-exist during biological treatment processes. Co-metabolism is the decisive actor when adaption time is relatively short as it was the case during the lab-scale experiments compared to real conditions. Further, the study indicates some potential of process enhancement of WWTPs ranging from straightforward implementations such as external carbon sources to more elaborated processes of bioaugmentation. [less ▲]Detailed reference viewed: 291 (37 UL) La "bancabilité" des infrastructures intégratives financés par les Institutions du développement en Afrique de l'OuestBassale, Wilfried Doctoral thesis (2015)Le terme « bancabilité » est l’une de ses expressions omniprésentes dans le discours des praticiens du financement des grands projets d’infrastructures sans que l’on ne sache précisément ce qu’il désigne ... [more ▼]Le terme « bancabilité » est l’une de ses expressions omniprésentes dans le discours des praticiens du financement des grands projets d’infrastructures sans que l’on ne sache précisément ce qu’il désigne. Lorsqu’elle est présentée comme étant les prérequis à l’octroi de financements des grands projets d’infrastructures par les institutions financières, la bancabilité ou la « financiabilité » ne demeure pas moins difficile à cerner. Sa nature suscite le débat. D’aucuns doutent qu’il s’agisse d’une notion juridique, d’autres y voient une pratique essentiellement financière assimilable à l’évaluation de la situation financière des candidats à un emprunt bancaire. Son régime est tout aussi incertain. Dès lors que la bancabilité est analysée à travers le prisme de critères ou de paramètres applicables aux promoteurs des projets d’infrastructures, la formation de ces « règles » puisqu’il s’agit effectivement de règles de conduite, de prescriptions, orientant le comportement des candidats-emprunteurs, mais également les conditions de leur mise en œuvre ne peuvent échapper à un encadrement juridique. À défaut de définition textuelle, identifier les déterminants de la bancabilité, saisir sa nature, comprendre cette pratique forgée par les professionnels du crédit, la distinguer de notions similaires – telles que la rentabilité, la solvabilité ou la dignité de crédit - sont d’autant plus essentiels que la bancabilité s’apparente à un concept émergent en droit dont la gestation est en cours. A cet égard, le régime applicable aux cas de manquement lors de l’appréciation de la conformité des projets d’infrastructure eu égard aux prérequis de bancabilité reste encore à définir. La présente étude entreprend une réflexion sur la valeur des critères juridiques de bancabilité tels qu’appliqués par les principales institutions financières du développement en Afrique de l’Ouest et explore les effets de leur mise en œuvre sur les cadres juridiques nationaux et régionaux. À partir de l’analyse de projets d’infrastructure de transport d’énergie favorisant l’intégration régionale des États-membres de la Communauté Économique des États d’Afrique de l’Ouest, l’étude met en lumière les écarts entre les principaux critères juridiques de bancabilité édictés par les institutions financières de développement et la pratique observée en Afrique de l’Ouest puis, elle propose des pistes d’évolution de ces critères de bancabilité. [less ▲]Detailed reference viewed: 183 (16 UL) La "Bancabilité" des infrastructures intégratrices financées par les Institutions financières du développement en Afrique de l'OuestBassale, Wilfried Doctoral thesis (2015)Detailed reference viewed: 38 (2 UL) Tant à cause de l'antiquité qu'à cause de l'excellence de sa fondation. Les origines des communautés régulières du duché de Luxembourg: Histoire - Mémoire - Historiographie (7e - 18e siècles)Charles, Marie-Cécile Sandrine Doctoral thesis (2015)Detailed reference viewed: 40 (8 UL) Analysis of the Urinary Proteomes of the Participants in the “Mars 500” Flight Simulation Program Using Advanced Mass Spectrometry TechniquesKhristenko, Nina Doctoral thesis (2015)Urine is a valuable material in the clinical proteomics studies as it may contain biomarkers for diagnosis of urinary tract and renal pathologies. Nevertheless, the high variability of protein abundances ... [more ▼]Urine is a valuable material in the clinical proteomics studies as it may contain biomarkers for diagnosis of urinary tract and renal pathologies. Nevertheless, the high variability of protein abundances in the context of normal homeostasis may mask the changes in the case of pathological protein expression and become a stumbling block in urinary proteome investigation. The main objective of this study was to define the normal (minimal) protein abundance variability in urine for a well-controlled group of healthy individuals. The analyses of urine samples collected in the frame of the “MARS 500” space flight simulation program was an unique opportunity to carry out such a study. In order to perform a reliable and systematic analysis of a large set of proteins in urine samples several challenges had to be overcome. First, a reliable sample preparation procedure had been established to address the problems associated to urine samples (e.g., the low overall protein concentration in urine). Second, a detailed map of the urinary proteome was created, including the identification of low abundant proteins in urine samples. High quality MS/MS spectra corresponding to a large set of identified peptides constituted the basis for a spectral library. The library allowed reinforcing the peptide identity confirmation by experimental spectra comparison with the reference spectra. Third, an LCMS/ MS method was devised to acquire systematically a large data set using the state-ofthe- art instrument with implemented dynamic correction of the targeted peptide monitoring time. The analysis of the urine samples collected over 100 days from six participants in the “MARS 500” program revealed unexpectedly large changes in the intra-personal protein abundances. Differences exceeding one order of magnitude between lowest and highest protein abundance measured within one individual were observed. However, some proteins exhibited a low abundance ratio, even across individuals. The proteins showing highest differences in abundance are presumably involved in the inflammatory response of the innate immune system. The present study provides a description of longitudinal protein abundance variation in urine in the context of the normal homeostasis and may be a resource for future biomarker studies. [less ▲]Detailed reference viewed: 53 (11 UL) HETEROGENITÄT IM LUXEMBURGISCHEN BILDUNGSSYSTEM – SCHULLAUFBAHNEN IM VERGLEICHBackes, Susanne Doctoral thesis (2015)This dissertation provides a detailed discussion of educational pathways through Luxembourg’s stratified school system, addressing educational inequalities in a longitudinal perspective. The link between ... [more ▼]This dissertation provides a detailed discussion of educational pathways through Luxembourg’s stratified school system, addressing educational inequalities in a longitudinal perspective. The link between stratification and educational inequality is well documented (Van de Werfhorst & Mijs, 2010; Pfeffer 2008). However, stratified systems themselves differ in permeability and in the given opportunity structure for intragenerational social mobility through changes of school track. This dissertation focuses on the occurrence of permeability in the stratified educational system of Luxembourg by analysing secondary school students’ pathways. The study attempts to answer the following main research questions: How can the students’ pathways through Luxembourg’s educational system be characterised and systemised? Does the use of track changes rather increase or decrease educational inequalities? The author deals with these questions by carrying out a triangulated design combining secondary data analysis (administrative panel dataset of all 5,301 students born in 1990 and PISA data) and narrative interviews with (former) school students. The conceptual framework is based on Boudon’s structural-individualistic approach (1974), Bourdieu’s capital theory (1983) and concepts of the sociology of youth (e.g. Zinnecker 2003). The cluster analysis reveals different types of complete pathways of secondary school students in Luxembourg. The largest group (37%) of the students follows an immobile academic pathway, and some students in the academic track leave this track early (7%). Within the technical track, which is further subdivided, more students follow a downwardly mobile pathway (21%) than an immobile pathway (17%). A small part of students within the technical track (12%) belongs to upwardly mobile types (only 2% of all the students make the transition from the technical to the academic track). The remaining 6% of the students follow careers that were interrupted at least once. Thus, 46% of all the students experience (multiple) broken secondary school pathways. The 15 qualitative interviews illustrate that the types of educational pathways are not directly linked to particular kinds of biographies in adolescent lives: Both, moratorium-oriented and transition-oriented students can be found in different pathway types. However, different trajectories afford different degrees of agency with respect to shaping the teenage years and creating professional identities. With regard to educational inequalities, results of logistic regression analyses reveal that socioeconomic and gender-specific placement gaps tend to increase during secondary schooling. On the other hand, migrant-specific disparities decrease through upwardly mobile pathways and higher continuity rates of students with migration backgrounds, whereby in case of vulnerable migrant groups this decreasing effect does not concern the transition to the highest tracks that are required for direct university entry. Further analyses show that the mechanisms behind different transition patterns vary between branching points and student groups in terms of achievement-related and decision-related effects. Thus, this study attempts to add to the body of knowledge of the permeability of educational systems and provides useful information to support the work of policy makers and consultants in the field of education. [less ▲]Detailed reference viewed: 208 (51 UL) Development of Alternative Proteomics Methods for Lung Cancer Biomarker EvaluationTrevisiol, Stéphane Doctoral thesis (2015)Lung cancer is a serious public health problem, killing millions of people around the world every year. It is the third most common cancer in Europe after colorectal cancer and breast cancer, but the ... [more ▼]Lung cancer is a serious public health problem, killing millions of people around the world every year. It is the third most common cancer in Europe after colorectal cancer and breast cancer, but the deadliest since it is often detected too late. Sensitive and reliable methods for early stage detection and drug response prediction could significantly improve the therapeutic treatment and survival rate of lung cancer patients. Although tremendous efforts in biomedical research have been made over the last decades to develop novel biomarkers for cancer diagnosis and treatment response, no reliable and specific panels of biomarkers are available for early lung cancer diagnosis. During the past decade mass spectrometry (MS) based proteomics has become an important approach to biological and clinical investigations. Most MS-based protein quantification approaches generally involve trypsin digestion of the endogenous proteins in biological samples, followed by a targeted liquid chromatography-mass spectrometry (LC-MS) analysis of signature peptides indicative of the proteins of interest. Trypsin cleaves proteins C-terminal of lysine and arginine residues generating peptides that are well suited for LC-MS/MS analysis. However, despite the undeniable advantages of trypsin, the enzyme is not optimal for all types of proteomics studies due to an uneven distribution of the cleavage sites in the human proteome. During a tryptic digestion also very short non-specific peptides (< 6 amino acids) are produced resulting in a loss of sequence protein coverage. This can be problematic as the missing peptide parts could contain crucial information for disease understanding, such as specific amino acid mutations or post- translational modifications of amino acid residues. Moreover, the generation of large numbers of short peptides results in an increased background complexity which is a main limiting factor in quantification experiments as it reduces the selectivity of the measurements, which in turn affects the sensitivity of the experiments. Isotope dilution strategies are frequently employed to achieve accurate quantification of the proteins of interest using calibrated isotopically labeled peptides as internal standards. In quantitative assays, which involve the use of stable isotope-labeled standards, the reliability and the accuracy of the experiments is principally dependent on the quality of the standards. Different factors can affect the standard concentration between the synthesis and its utilization, such as incomplete solubilization, non-specific adsorption to hydrophobic surfaces or aggregation. To ensure an accurate quantification the internal standards need to be verified immediately before analysis. The purpose of this PhD thesis was to develop new proteomic approaches to remedy these limitations by using, instead of trypsin, alternative enzymes and by developing a quantification approach based on concatenated polypeptide standards containing a cleavable reporter peptide for accurate quantification. [less ▲]Detailed reference viewed: 249 (6 UL) Example-Dependent Cost-Sensitive Classification with Applications in Financial Risk Modeling and Marketing AnalyticsCorrea Bahnsen, Alejandro Doctoral thesis (2015)Several real-world binary classification problems are example-dependent cost-sensitive in nature, where the costs due to misclassification vary between examples and not only within classes. However ... [more ▼]Several real-world binary classification problems are example-dependent cost-sensitive in nature, where the costs due to misclassification vary between examples and not only within classes. However, standard binary classification methods do not take these costs into account, and assume a constant cost of misclassification errors. This approach is not realistic in many real-world applications. For example in credit card fraud detection, failing to detect a fraudulent transaction may have an economical impact from a few to thousands of Euros, depending on the particular transaction and card holder. In churn modeling, a model is used for predicting which customers are more likely to abandon a service provider. In this context, failing to identify a profitable or unprofitable churner has a significant different economic result. Similarly, in direct marketing, wrongly predicting that a customer will not accept an offer when in fact he will, may have different financial impact, as not all customers generate the same profit. Lastly, in credit scoring, accepting loans from bad customers does not have the same economical loss, since customers have different credit lines, therefore, different profit. Accordingly, the goal of this thesis is to provide an in-depth analysis of example-dependent cost-sensitive classification. We analyze four real-world classification problems, namely, credit card fraud detection, credit scoring, churn modeling and direct marketing. For each problem, we propose an example-dependent cost-sensitive evaluation measure. We propose four example-dependent cost-sensitive methods; the first method is a cost-sensitive Bayes minimum risk classifier which consists in quantifying tradeoffs between various decisions using probabilities and the costs that accompany such decisions. Second, we propose a cost-sensitive logistic regression technique. This algorithm is based on a new logistic regression cost function; one that takes into account the real costs due to misclassification and correct classification. Subsequently, we propose a cost-sensitive decision trees algorithm which is based on incorporating the different example-dependent costs into a new cost-based impurity measure and a new cost-based pruning criteria. Lastly, we define an example-dependent cost-sensitive framework for ensembles of decision-trees. It is based on training example-dependent cost-sensitive decision trees using four different random inducer methods and then blending them using three different combination approaches. Moreover, we present the library CostCla developed as part of the thesis. This library is an open-source implementation of all the algorithms covered in this manuscript. Finally, the experimental results show the importance of using the real example-dependent financial costs associated with real-world applications. We found that there are significant differences in the results when evaluating a model using a traditional cost-insensitive measure such as accuracy or F1Score, than when using the financial savings. Moreover, the results show that the proposed algorithms have better results for all databases, in the sense of higher savings. [less ▲]Detailed reference viewed: 398 (11 UL) Die Herausforderung der dritten Sprache – eine Grounded-Theory-Studie zu sprachlichen Praktiken und Repräsentationen von Mehrsprachigkeit bei Studierenden dreisprachiger Masterstudiengänge an der Universität LuxemburgStoike-Sy, Rahel Doctoral thesis (2015)The University of Luxembourg presents itself as an international and multilingual university, two attributes that may seem at odds to those who equate internationalization with anglicization. In fact ... [more ▼]The University of Luxembourg presents itself as an international and multilingual university, two attributes that may seem at odds to those who equate internationalization with anglicization. In fact, more than 50 % of students of this officially trilingual institution come from outside Luxembourg and the proportion of international students’ increases at the Master’s level. While the majority of Master study programs in the winter term 2012/13 were mono- or bilingual, four trilingual Masters have been offered as well. Three of them used French, English and German as languages of instruction, another one Luxembourgish, French and German. This dissertation investigates linguistic practices and representations of individual and institutional multilingualism by students and study directors in four trilingual Master study programs. The exploratory study combines an ethnographic approach with constructivist Grounded Theory. The corpus comprises around 90 hours of participant observation, 47 field notes, 19 questionnaires, and 9 interviews with students and 4 with course directors. The data has been generated in 2012 and 2013. The general research question “How do students experience individual and institutional multilingualism in trilingual Master programs?” has been split up in three specific questions: (1) How are the linguistic repertoires of the involved actors categorized? (2) Which representations of institutional multilingualism and a “multilingual study program” are constructed by students and study directors? (3) In which situations do multilingual language practices emerge in the program? The results show that the configuration of linguistic repertoires, the motivation for a Master program and their expectations, among other factors, play a role in the construction of representations of multilingualism. Students and lecturers have different linguistic resources in one, two or all three of the program languages. On the basis of the official presentation of the programs, some students expect a symmetrical form of multilingualism, but perceive an asymmetrical use of the three languages in practice. The hierarchical use of languages is accompanied by a marginalization of German in each Master and explained by the limited repertoires of students or lecturers. Receptive multilingualism is practiced in some contexts or presented as a goal and opposes the view that a multilingual study program should mean studying in three languages. The students’ expectations of support for language learning and the institutional offer of language courses diverge. While in two Masters language courses in French and German for beginners are offered, support is missing for advanced learners and for academic language. Overall, the findings suggest an influence of individual and collective linguistic repertoires on linguistic practices of teaching and studying as well as on the implementation of institutional multilingualism in practice. While students mention changes of former study practices during their Master studies, lecturers develop spontaneous strategies to deal with the linguistic heterogeneity of their groups, whereby the degree of multilingualism varies. The significance of the core category “the third language” can be explained by the fact that some students begin their studies with no or only little language resources in one of the program languages and by their tendency to hierarchize languages. The results of this qualitative study have implications for the language policy of multilingual study programs. A clear definition of a language competence profile for enrolling and finishing a multilingual study program as well as specific language learning objectives are recommended. Finally, an integration of language learning in content courses according to the CLIL-model is proposed. [less ▲]Detailed reference viewed: 181 (16 UL) Model-Driven Security With Modularity and Reusability For Engineering Secure Software SystemsNguyen, Phu Hong Doctoral thesis (2015)Context: The more human beings depend on software systems, the more important role that software security engineering must play to build secure software systems. Model-Driven Security (MDS) emerged more ... [more ▼]Context: The more human beings depend on software systems, the more important role that software security engineering must play to build secure software systems. Model-Driven Security (MDS) emerged more than a decade ago as a specialised Model-Driven Engineering (MDE) research area for engineering secure software systems. MDS is promising but not mature yet. Our recent systematic literature review (SLR) has revealed several current limitations and open issues in the state of the art of MDS research. Objectives: This PhD work aims at addressing three of the main open issues in the current state of the art of MDS research that are pointed out by the SLR. First, our SLR shows that multiple security concerns need to be handled together more systematically. Second, true Aspect-Oriented Modelling techniques for better ensuring the separation- of-concern in MDS approaches could have been leveraged more extensively. Third, complete tool chains based on integrated MDE techniques covering all the main stages of the development cycle are emerging, but still very rare. Methods: On one hand, we develop a full MDS framework with modularity based on domain-specific modelling, model transformations, and model-based security testing. This MDS framework can help us to deal with complex delegation mechanisms in access control administration, from modelling till testing. On the other hand, we propose a highly modular, reusable MDS solution based on a System of Security design Patterns (SoSPa) and reusable aspect models to tackle multiple security concerns systematically. Results: First, an extensive SLR has been conducted for revealing and analysing the current state of the art of MDS research. Second, a full MDS framework focusing on modularity has been proposed that integrates domain-specific modelling, model transformations, and model-based security testing to support all the main stages of an MDS development cycle. Third, we have developed a highly reusable, modular MDS approach based on a System of Security design Patterns for handling multiple security concerns together systematically. Finally, we have showed how our MDS approaches can be integrated in a full MDS framework, called MDS-MoRe, which could be the basis of a complete tool chain for MDS development of secure systems. Conclusion: In this thesis, integrated MDS methodologies with modularity and reusability have been proposed for engineering secure software systems. This work has tackled three main current open issues in MDS research revealed from an extensive SLR. [less ▲]Detailed reference viewed: 360 (12 UL) Role of Calprotectin as a Modulator of the IL27-Mediated Inflammatory Response of Endothelial CellsDorosz, Susann Antonia Doctoral thesis (2015)Cardiovascular diseases (CVD) are the leading causes of death with a morbidity of around 40% worldwide. Their development occur long before any symptoms are clinically evident. An underlying endothelial ... [more ▼]Cardiovascular diseases (CVD) are the leading causes of death with a morbidity of around 40% worldwide. Their development occur long before any symptoms are clinically evident. An underlying endothelial dysfunction plays a fundamental role in the pathogenesis of cardiovascular events and is the central feature of atherosclerosis, which often appears prior to other CVD. However, the involvement of the chronic inflammatory state of the endothelium in the early mechanisms leading to the atherosclerotic phenomenon, which includes the protein-based communication between leukocytes and inflamed endothelial cells, remains to be further investigated. In this context of atherosclerosis, several key players have already been identified, but the role of the cytokines IL17D, IL27, and IL32γ is less well understood. In addition, evidence for the impact of calprotectin on promoting atherosclerosis has been reported, but its modulatory role on cytokine communication is still unclear. In this study, we first analysed the inflammatory responses of monocytes stimulated with the potent agonist TNFα to simulate a stress-induced inflammatory state. In order to characterize the monocytes as a potential cellular source of IL17D, IL27, IL32γ, and calprotectin, the regulation of gene expression was studied based on microarray data and qPCR. Highly significant up-regulations of IL27 subunit EBI3 and IL32 gene expressions were confirmed in TNFα-stimulated THP-1 cells. Furthermore, we were able to determine elevated intracellular IL27 and calprotectin protein levels in TNFα- stimulated THP-1 cells. In a second part, Human Umbilical Vein Endothelial Cells (HUVECs) were stimulated with IL17D, IL27, IL32γ, and calprotectin to characterize the induced inflammatory responses regarding gene expression. A gene-array qPCR screening demonstrated higher differential gene expression (DGE) after IL27 compared to IL17D, IL32γ, and calprotectin stimulation. Highest IL27-mediated DGEs were ob- served for CXCL10, CXCL11, IL7, and IL15. In order to highlight potential calprotectin modulatory effects on these genes, time course experiments of HUVECs stimulated with IL27+/-calprotectin were assessed by qPCR. We identified modulatory effects of cal- protectin on IL27-induced CXCL10 and IL15 gene expressions. Furthermore a mass spectrometry-based proteomic analysis of IL27+/-calprotectin-stimulated HUVECs enlightened a modulatory role of calprotectin in the late differential regulation of proteins such as the IL27 downstream effector STAT1. A literature-based pathway analysis of significant regulated proteins emphasized that calprotectin-modulated IL27 activity was able to decrease the probability of the development of atherosclerosis. Altogether, our findings suggest that calprotectin may exert a regulatory role on cytokine-mediated inflammatory responses and highlight the need of further investigations in the understanding of atherosclerosis development. [less ▲]Detailed reference viewed: 104 (25 UL) Les concepts d'indépendance de la justice : une analyse historique et comparée (Angleterre, Allemagne et France)Janssen-Bennynck, Clémence Doctoral thesis (2015)Cette thèse examine les divers concepts de l’indépendance de la justice en Angleterre, en Allemagne et en France. S’inscrivant dans une approche cognitive et théorique, son objectif essentiel est de ... [more ▼]Cette thèse examine les divers concepts de l’indépendance de la justice en Angleterre, en Allemagne et en France. S’inscrivant dans une approche cognitive et théorique, son objectif essentiel est de chercher à identifier, approfondir et suivre les évolutions du principe d’indépendance de la justice dans trois traditions nationales majeures au sein de l’Europe. Une typologie des différents sens possibles de l’indépendance de la justice est proposée au lecteur dans le chapitre préliminaire. L’analyse est, ensuite, conduite en optant pour un plan en trois parties, chaque partie étant consacrée à l’un des trois pays. Une analyse comparative transversale est, enfin, présentée dans la conclusion. [less ▲]Detailed reference viewed: 441 (32 UL) Multilingualism and Early Education: An Ethnography of Language Practices and Processes of Institutionalisation in Luxembourgish Early Childcare SettingsSeele, Claudia Doctoral thesis (2015)During the last twenty years, the Luxembourgish system of early childhood education and care (ECEC) has been undergoing some considerable transformations in light of growing demands by social, economic ... [more ▼]During the last twenty years, the Luxembourgish system of early childhood education and care (ECEC) has been undergoing some considerable transformations in light of growing demands by social, economic and educational policies. In the multilingual context of Luxembourg, these demands are especially complex, ranging from language promotion and school preparation to contributing to social cohesion and to the integration of a heterogeneous society. The early educational practice today is thus confronted with multiple, at times also divergent expectations. Instead of asking how effectively educational practices might meet these demands and expectations, my research rather takes a non-normative approach by investigating how multilingualism is actually dealt with in the everyday practice of the day care centres. Drawing on praxeological and institutional perspectives as analytical tools, the thesis aims at a better understanding of the everyday accomplishment of the early educational practice in light of these societal developments. Language is thus regarded as a social practice, putting the focus on the actual doing of language and its contribution to the practical enactment of an institutional order. Institutionalisation, here, is understood as the intricate processes of referring and answering to external expectations in everyday practice in order to negotiate what ‘early childhood education and care’ actually is and means. Hence, not everything that happens in educational fields is per se ‘education’; rather it has to be performed and practically constituted as such in response to certain institutionalised norms, values and expectations. In order to investigate how language practices contribute to processes of institutionalisation in ECEC, an ethnographic research has been carried out in three state-funded Luxembourgish day care centres over the course of three years. Pertinent questions that guided my observations and analyses were for example: What different kinds of language practices can be observed in the centres? How are these language practices, on the one hand, conducive to the accomplishment of an institutional order and are, on the other hand, themselves constrained by this order? What are the respective parts of adults and children in these processes? How is early education thereby constituted but also challenged or transformed? Data analysis is based on a reflexive and constructivist Grounded Theory approach and yielded several interrelated aspects of language-mediated institutionalisation processes: First, language serves to constitute institutional boundaries and to differentiate the pedagogical social space from the ‘outside’ or ‘everyday’ world. Second, language also contributes to the creation of an institutional order ‘inside’ this pedagogical space and helps to position actors within this order. Third, language is part of processes of routinisation and incorporation that serve to stabilise the institutional practice. Finally, language is also involved in representing the early educational practice vis-à-vis its constitutive outside, such as the family and the school, thus supporting its claims to legitimacy. These processes, however, are not as straightforward as it may seem, because language also plays a part in destabilising processes of institutionalisation and bringing forward institutional changes. For example, language practices also transcend and fracture the monolingual imaginings of pedagogical space. They may not only constitute and support but also challenge and resist the institutional order as well as question its legitimacy. The study raises some important further questions that are addressed in the final chapter: How can ethnographic research contribute to processes of practice development in ECEC? How do institutional factors both enable and constrain the early educational practice? In what ways do the children themselves contribute to the practical accomplishment of early educational realities? What are the limitations of the study and further lines of inquiry for future research? [less ▲]Detailed reference viewed: 249 (19 UL) Super-Resolution Approaches for Depth Video EnhancementAl Ismaeil, Kassem Doctoral thesis (2015)Sensing using 3D technologies has seen a revolution in the past years where cost-effective depth sensors are today part of accessible consumer electronics. Their ability in directly capturing depth videos ... [more ▼]Sensing using 3D technologies has seen a revolution in the past years where cost-effective depth sensors are today part of accessible consumer electronics. Their ability in directly capturing depth videos in real-time has opened tremendous possibilities for multiple applications in computer vision. These sensors, however, have major shortcomings due to their high noise contamination, including missing and jagged measurements, and their low spatial resolutions. In order to extract detailed 3D features from this type of data, a dedicated data enhancement is required. We propose a generic depth multi-frame super-resolution framework that addresses the limitations of state-of-the-art depth enhancement approaches. The proposed framework does not need any additional hardware or coupling with di erent modalities. It is based on a new data model that uses densely upsampled low resolution observations. This results in a robust median initial estimation, further refined by a deblurring operation using a bilateral total variation as the regularization term. The upsampling operation ensures a systematic improvement in the registration accuracy. This is explored in different scenarios based on the motions involved in the depth video. For the general and most challenging case of objects deforming non-rigidly in full 3D, we propose a recursive dynamic multi-frame super-resolution algorithm where the relative local 3D motions between consecutive frames are directly accounted for. We rely on the assumption that these 3D motions can be decoupled into lateral motions and radial displacements. This allows to perform a simple local per-pixel tracking where both depth measurements and deformations are optimized. As compared to alternative approaches, the results show a clear improvement in reconstruction accuracy and in robustness to noise, to relative large non-rigid deformations, and to topological changes. Moreover, the proposed approach, implemented on a CPU, is shown to be computationally efficient and working in real-time. [less ▲]Detailed reference viewed: 219 (39 UL) Geplante Bildung für die freie Welt. Die OECD und die Entstehung einer technokratischen BildungsexpertiseBürgi, Regula Doctoral thesis (2015)Today, national education polices are increasingly informed and affected by an international education policy space: ‘World education managers,’ equipped with standardized tests and indicators, identify ... [more ▼]Today, national education polices are increasingly informed and affected by an international education policy space: ‘World education managers,’ equipped with standardized tests and indicators, identify ‘best practices’ that are assumed to be valid across all nation states, largely irrespective of their specific historical, cultural and educational contexts. These global experts have found many hosts and platforms for their views within international governmental organizations, foremost among them the Organization for Economic Co-operation and Development (OECD). With instruments such as the Programme for International Student Assessment (PISA), OECD has become – without having any educational mandate – a hegemonic power in the field of international education policy. The OECD is thus a significant example for a new kind of educational expertise that is characterized by a permanent, institutionalized link between policy and research. For all its ‘influence’ on contemporary policy, little is known about the emergence of this international policy space, its inner logics – its ‘managers’ and the origins of their ‘universal language’. Whereas the current research literature often associates the origins of this internationalization with the fall of the Iron Curtain, this PhD thesis argues that its roots were established and shaped during – and not after – the Cold War, with the formative period occurring during the late 1950’s and the 1960’s. By reconstructing OECD’s emerging role as an expert in education, this thesis sheds light on particular ‘actors’ or rather ‘networks’ and the ‘styles of reasoning’ that enabled, shaped, and legitimized this new international authority. More precisely, this thesis describes how, against the background of a Cold War ‘culture of control,’ a space was created for the rise of different technocratic networks. These networks were eventually characterized by the belief that education bears the ultimate means for solving the problems of societies. Within the OECD these technocratic networks found the ideal institutional platform to give their ‘styles of reasoning’ expression and to establish and to diffuse a specific goal-oriented, quantitative research culture with a strong ‘social engineering’ bent. The epistemology and methods of this specific form of research originated not the least from military war research, whereby the USA acted both as a model and as a catalyst. In the name of the ‘free world’ – as the thesis concludes – a cult of expertise was established leading less to forms of democracy than to a monarchy of ‘evidence’. By disentangling and identifying the ‘styles of reasoning’ as well as the ‘networks’ that were crucial in establishing OECD’s educational expertise, this thesis highlights that a policy phenomenon like the OECD’s PISA does not derive ‘out of the blue’ but, on the contrary, has its roots in a longer history – a decisive context that is often neglected in current explanations assembled around buzzwords like ‘globalization’ or ‘world culture’. Moreover this thesis contributes to the reconstruction of the establishment of a new institutional site that generates a specific kind of knowledge and oscillates between policy and research whilst bypassing the traditional research institutions – the universities. [less ▲]Detailed reference viewed: 272 (18 UL) Exploiting linguistic resources for self-employment: Workplace practices and language use of Thai immigrant entrepreneurs in the German peripherySerwe, Stefan Karl Doctoral thesis (2015)This thesis is about immigrants in self-employment in Germany. More specifically, it is about immigrants who make a culturally-endowed practice or knowledge economically available in their new home. These ... [more ▼]This thesis is about immigrants in self-employment in Germany. More specifically, it is about immigrants who make a culturally-endowed practice or knowledge economically available in their new home. These immigrant business owners are generally referred to as ethnic entrepreneurs. Yet, according to research and widely-held public opinions in Germany, a problem that hampers the success of these businesses is the owner's lack of proficiency in the German language, which apparently impedes them from accessing institutional support and from offering their services to the majority population. However, the ways that language competence actually affects the entry of immigrants into self-employment and the execution of their daily work as business owners has received only insufficient attention, including from a sociolinguistic perspective. Hence, this thesis aspires to examine the pathways of immigrants into self-employment and how these pathways are shaped by the owners' language knowledge. Secondly, by analysing the workplace practices in close empirical detail, it aims to understand how the owners' language knowledge impacts the execution of their work and whether these practices constitute sites of language learning for the owners. Thirdly, it intends to document the challenges that the business owners face at their workplaces, in order to understand to what extent they are due to insufficient levels of language knowledge. In order to answer these research questions, this study focuses on three businesses owned and operated by first-generation female immigrants from Thailand in the federal state of Saarland in southwest Germany. Businesses by Thai immigrants are particularly interesting for the purposes of this investigation, because they have flourished in recent years and because they offer their services in markets that target the majority, primarily German-speaking population. The ventures are typical examples of ethnic small businesses created by Thai immigrants in Germany: Thai massage salons and food retails stores. The first is a large Thai massage salon run by Kanita, the second a small Thai massage salon managed by Patcharin, and the third business is a food retail store owned and operated by Wipa. The three owners (and their staff) differ in terms of their competence in German. Kanita has only minimal competence in German, Patcharin has partial competence, while Wipa has maximum competence in the language. The analysis of the pathways into self-employment of these three owners exhibits a number of similarities. In all three cases, their migration to Germany was triggered by marriage to a German national. Previously, they all had professional careers which were directly connected to their appropriation of English, a language that later enabled communication with their German husbands. While their move to Germany was generally motivated by prospects of a better future, they were unable to find work due to a lack of German proficiency. German was primarily learned informally. Informal learning was fostered by their prior experience of language learning, their individual engagement in the form of self-study and reflexivity, a deliberate exposure to German through media, and their engagement with native speakers in practices towards which that they had developed an affinity. Interestingly, these practices were either their previous professional practices or activities that they took up after migration and later on developed into their own businesses. Realising the demand for their services in the open market and among the majority population kindled Kanita's, Patcharin's and Wipa's flame to enter self-employment. They deliberately adapted their services to the requirements of their customers, but also in reaction to prejudices about their professions. The support of their husbands and other associates was also significant, as they handled tasks that were difficult to perform linguistically, as, for example, the registration of the businesses and the preparation of administrative paperwork. In sum, these findings suggest that an advanced standard level of German was no prerequisite for these owners to enter self-employment, but that the prospects of engaging in self-employed work acted as an incentive to improve their German language skills. A detailed analysis of the workplace practices at Kanita's Massage Salon shows that working with minimal competence in German is possible, but that its success depends on several factors. To complete their workplace actions, Kanita and her staff draw on both resources in their linguistic repertoires, Thai and German. In addition, all workplace actions are designed as routine actions with discursive routines that all staff members are able to master quickly. Their successful accomplishment also depends on the customers' familiarity with these actions. Therefore, formal inconsistencies in German do generally not impede the performance of work, but problems are primarily due to the staff's or the customer's inexperience with the routines. If problems occur, they tend to be solved in cooperation with colleagues or by drawing on the material resources available to the staff members. In comparison to Kanita, Patcharin and her staff have partial competence in German, which is instrumental for the performance of the key practices at their workplace. The analysis shows that their restricted competence in German is important for their work, as it provides the tools for Patcharin and her staff to perform discursive practices during the massage treatment, such as finding out about their clients' health problems, building rapport with clients, giving instructions or clarifications about the treatment, or providing assessments of their customers' health issues. Talk is an important part of the massage treatment at Patcharin's salon and it aids to construct the professional identity that Patcharin claims for herself, namely to provide a high-quality and personalised service to her customers. Thai is less relevant, but in interactions between Patcharin and her staff it serves to exchange information and coordinate work. Wipa has maximum competence in German and Thai, which allows her to manage her store and serve her customers independently and competently in line with her professional aspirations. The key practices at her store of explaining and ordering stock illustrate how Wipa relies on both the use of Thai and German to effectively perform these actions. Her maximum competence in German and in Thai permits her to make 'rational' choices about the suitability of her suppliers and to provide her customers with advice that is tuned to their linguistic and cultural background. The conclusions drawn from these findings are that an advanced competence in German in not a prerequisite for immigrant entrepreneurs to start their businesses. The owners attune their workplace actions to the level of competence in their linguistic repertoires and operate effectively. Moreover, self-employed work provides the owners with the necessary motivation and the need to appropriate German. On the other hand, the data suggest that a greater proficiency in German becomes important, if the immigrant entrepreneur wants to differentiate her business from direct competitors, as it allows them to move beyond the concrete performance of routine actions. [less ▲]Detailed reference viewed: 327 (21 UL) European Causation in Tort Law: a Comparative Study with emphasis on Medical Law in the United Kingdom, Germany and France and LuxembourgHyslop, EDWARD IAN Doctoral thesis (2015)This purpose of this paper is to explore how the different jurisdictions under consideration here treat the legal notion of causation. These jurisdictions are the United Kingdom, Germany and France and ... [more ▼]This purpose of this paper is to explore how the different jurisdictions under consideration here treat the legal notion of causation. These jurisdictions are the United Kingdom, Germany and France and Luxembourg. The problem of causation has been described as insoluble and I shall not be trying to solve it. Rather I shall consider how each of the jurisdictions here treats causation in the law, the better to ascertain whether there can be any common European idea of causation in this field. The reason for this is not only as two of the European projects aiming at codification in tort law seek to attempt if not strictly a definition of causation then recommendations in ways in which it could be refined. The European Court of Justice itself has been mandated to extract general principles common to European Union member states with regard to non-contractual obligations which can be applied when faced with a problem in tort law. I must necessarily explain the notion of causation more generally before considering causation in the law so causation itself is understood. Within the sphere of causation in the law, there are a number of theories that I examine, which can be found, to a greater or lesser extent (or sometimes not at all), in one form or another, in the jurisdictions under consideration. My conclusion is that there can be no common idea in causation from which principles in furtherance of any European codification projects may be stated. In most cases in court, a discussion of causation is not even entered into, as it is not controversial. There can be no “common sense” solutions in cases where causation is in doubt. I offer no principles. I make only one suggestion at the end with regard to experts’ reports. The originality I hope to bring to this area of law is that this will be the first work that considers French (and Luxembourg), German and British law under one cover. I conclude by what seems to be the opposite view from many jurists in that, who hold that, however courts may arrive there “the results are [or will be] just the same” in causation. [less ▲]Detailed reference viewed: 234 (7 UL) INTEGRATED ANALYSIS OF TRANSCRIPT-LEVEL REGULATION OF HUMAN ADIPOGENESIS AND CELL TYPE-SELECTIVE DISEASE ASSOCIATION OF HIGH REGULATORY LOAD GENESGalhardo, Mafalda Sofia Doctoral thesis (2015)Most diseases are characterized by altered epigenetic and metabolic states, pointing to the need of a global and combined understanding of mechanisms underlying epigenetic and metabolic changes as an ... [more ▼]Most diseases are characterized by altered epigenetic and metabolic states, pointing to the need of a global and combined understanding of mechanisms underlying epigenetic and metabolic changes as an important piece to enable disease eradication. Adipocytes impact systemic homeostasis and their differentiation encompasses a phenotypic change whose function becomes impaired with diseases such as obesity and metabolic syndrome. Following an integrative systems biology approach, we combined different omics data from the differentiation of Simpson-Golabi-Behmel syndrome (SGBS) adipocytes with a human metabolic model to observe key metabolic changes upon differentiation, their regulation and relevance for disease. Pursuing the link to disease, we used public data from the genome-wide binding of TFs and location of active enhancers to test for disease association in function of the regulatory load, revealing a cell type-selective enrichment for disease of the high regulatory load genes. Diverse experimental data were collected, covering a gene expression time-course during adipogenesis, with identification of miR-27a, miR-29a and miR-222 target genes, the genome-wide binding profiles of PPARg, C/EBPa and LXRa , and the H3K4me3 histone modification mark for actively transcribed transcription start sites (TSSs). Metabolic genes showed a highly dynamic expression pattern during adipogenesis, most being targeted by PPARg and C/EBPa . Lipid metabolism pathways including triacylglyceride synthesis showed extensive and combinatorial regulation by TFs and miRNAs, converging on known dyslipidemia genes. For data visualization, we developed a web portal that interactively renders metabolic pathways with omics data overlaid (IDARE, http://systemsbiology.uni.lu/idare.html). Public ChIP-seq data revealed a general principle of higher disease association of genes under higher regulatory control in a cell type-selective manner. First, data from the genome-wide binding of 10 TFs in HUVEC cells showed an enrichment for vascular diseases on metabolic genes targeted by > 6 TFs. Second, data from the binding of a total of 93 TFs confirmed the enrichment for disease association of genes with the top TF load in 8 additional cell lines. Finally, active enhancer data from 139 samples spanning 96 cell types and tissues demonstrated the cell type-selective disease enrichment of the genes with the highest active enhancer load. High regulatory load genes enriched for disease association beyond genetic variation, including association types like “altered expression” and “biomarker”, among others. Additionally, high regulatory load genes appeared on average in more KEGG pathways and had higher betweenness centrality in a liver disease network than other genes, showing longer 3’UTRs harboring more binding sites for diverse microRNA families, suggesting also a higher post-transcriptional regulatory load and a role as signal integrators within biological networks. Our results point to the pertinence of including high regulatory load genes for unbiased prioritization of novel candidate genes for disease association. [less ▲]Detailed reference viewed: 488 (10 UL) Unternehmertum in der Frühpädagogik - Berufsentscheidungen in LuxemburgRicken Geb. Weber, Kathrin Hannelore Doctoral thesis (2015)The observations, that founders of private crèches in Luxemburg possibly have a mainly non-pedagogic, but economic driven professional background, hire for the pedagogic management of their crèches ... [more ▼]The observations, that founders of private crèches in Luxemburg possibly have a mainly non-pedagogic, but economic driven professional background, hire for the pedagogic management of their crèches qualified personnel and, compared to the gender ratio of specialized staff, are mainly male persons, cannot be confirmed with this qualitative research. The results show a certain dichotomy, but not, as suggested, concerning the job profiles ‘employed nursery nurse’ and ‘entrepreneur’. In contrast, within the group of entrepreneurs a tendency towards a dichotomy in terms of practicing tasks, early pedagogic or managerial, and size of the business, single or several crèches, appears. The assumption, that mainly male persons found private crèches cannot be confirmed. In contrary women appear to be in majority in all fields of business activity, so that there might possibly be a tendency towards a permeant feminisation of the whole private early pedagogic market. This is insofar surprising, as in this commercial part of the early pedagogic market with the new professional opportunity of being an entrepreneur due to the reflection of the literature more heterogeneity was expected. [less ▲]Detailed reference viewed: 144 (2 UL) Community-based vehicular networks for traffic information systemsGrzybek, Agata Doctoral thesis (2015)Traffic information systems (TIS) monitor road traffic conditions with the goal of improving the efficiency of road networks. Given the ever increasing number of cars, TIS are becoming more critical, as ... [more ▼]Traffic information systems (TIS) monitor road traffic conditions with the goal of improving the efficiency of road networks. Given the ever increasing number of cars, TIS are becoming more critical, as they help reduce traffic congestion which have large negative social, economical, and environmental impact. Current TIS have several drawbacks. First, there are insufficient sources of traffic data, that often require either expensive sensing infrastructure or a contract with a network provider owning GPS data. Secondly, they are often limited by a centralised architecture introducing both delays in delivery of real-time data and a single-point of failure. Finally, even after collecting traffic information, they provide no easy way to effectively relay information to drivers or apply traffic management strategies. New vehicle-to-vehicle (V2V) communication technologies can potentially aid in overcoming these limitations. Using V2V, vehicles can communicate with each other and exchange traffic information within an ad hoc vehicular network (VANET). VANETs could drastically change the nature of traffic systems, moving from a centrally-controlled to a self-organised complex system covering every road segment.This thesis studies the potential of VANETs in the context of traffic data collection and traffic management using a multidisciplinary approach. We combine knowledge of networking protocols, distributed systems, and traffic theory to propose novel solutions for TIS. First, we propose a TrafficEQ system---a VANET-based TIS, that uses pure V2V communication to collect and disseminate traffic information among vehicles. Moreover, TrafficEQ provides intelligent route guidance based on a probabilistic route choice strategy. The system is evaluated using a simulation platform developed with realistic real-world scenarios. We demonstrate that TrafficEQ deals with challenging non-predictable traffic congestion better than traditional route guidance systems can. Secondly, we propose grouping vehicles into communities by similarity of their mobility patterns to improve traffic congestion detection and analysis. To facilitate this, we present the Crowdz algorithm---a community detection algorithm for VANETs. Extensive analysis on large-scale vehicular networks show that detected communities are more stable than those in a competitive algorithm. Lastly, we introduce an application which uses communities to detect and analyse traffic congestion. Simulation experiments show that identification of congested communities can help in applying appropriate control strategies. [less ▲]Detailed reference viewed: 243 (18 UL) Interaction in Luxembourgish as an Additional Language: An analysis of language learning as related to affordances among multilingual adult learnersLambo Ouafo, Adrienne Doctoral thesis (2015)This study examines affordances for Luxembourgish as the ‘speak-able’ and ‘use-able’ of the target language in the learning environment. Grounded in the Sociocultural theory that assumes that active ... [more ▼]This study examines affordances for Luxembourgish as the ‘speak-able’ and ‘use-able’ of the target language in the learning environment. Grounded in the Sociocultural theory that assumes that active verbal engagement in naturally occurring interaction enables learners to develop knowledge of target language use, the study analyses Luxembourg learners’ discourses and actions in interaction. Results show that in a context where the target language's functions are limited to "juste les petites conversations wie geet et?" [only mini-dialogues how are you?], metalinguistic awareness is crucial for the occurrence of executive affordance that allows for language learning and development to take place. Awareness of the context on the one side and of the status of the target language on the other side plays an important role in the learning and development of Luxembourgish. [less ▲]Detailed reference viewed: 139 (14 UL) Mediale und sprachliche Möglichkeitsräume in digitaler Schriftlichkeit - Eine Studie zu Facebook-Pinnwänden in LuxemburgBelling, Luc Doctoral thesis (2015)Detailed reference viewed: 228 (29 UL) Studying Signal Transduction Networks with a Probabilistic Boolean Network ApproachTrairatphisan, Panuwat Doctoral thesis (2015)In recent years, various modelling approaches in systems biology have been applied for the study and analysis of signal transduction networks. However, each modelling approach has its inherent advantages ... [more ▼]In recent years, various modelling approaches in systems biology have been applied for the study and analysis of signal transduction networks. However, each modelling approach has its inherent advantages and disadvantages, so the choice has to be made based on research objectives and types of data. In this PhD dissertation, we propose probabilistic Boolean network (PBN) as one of the suitable modelling approaches for studying signal transduction networks with steady-state data. The steady-state distribution of molecular states in PBN can be correlated to the steady-state proteomic profiles generated from wet-lab experiments. In addition, the relevance of interactions within signalling networks can be assessed through the optimised selection probabilities. These features make PBNs ideal for describing the properties of signal transduction networks at steady-state with some uncertainty on network topologies. To investigate the applicability of PBNs for the study of signal transduction networks, we developed optPBN, an optimisation and analysis toolbox in the PBN framework. We demonstrated that optPBN can be applied to optimise a large-scale apoptotic network with 96 nodes and 105 interactions. Also, it allows for network contextualisation in a physiological context of primary hepatocytes through the analysis on optimised selection probabilities. Similarly, we also applied optPBN to study deregulated signal transduction networks in pathological contexts, i.e. the PDGF signalling in gastrointestinal stromal tumour (GIST) and the L-plastin signalling in breast cancer cell lines. By integrating prior information on network topology from literature with context-specific experimental data, contextualised PBNs can be derived which in turn provide additional insights into biological systems such as the importance of certain crosstalk interactions and the comparative signal flows at steady-state in non-metastatic versus metastatic cancer cell lines. In addition to the applications on fundamental research, we also explored the applications of PBNs in a pharmaceutical setting where detailed mechanistic models are usually used. Here, we applied optPBN as a tool for network ontextualisation. A proof-of-concept example on a small model demonstrated that optPBN helped to pre-select the suitable network structure according to the provided experimental data prior to the building and optimisation of detailed mechanistic models. Such application is foreseen to be applied in a pharmaceutical setting and to explore additional applications such as combinatorial drugs’ effect and toxicity screening. [less ▲]Detailed reference viewed: 148 (26 UL) Régulation ou règlementation des fonds islamiques en Europe?Bouharati, Bahya Doctoral thesis (2015)Les fonds islamiques intègrent dans leur stratégie d’investissement des critères d’investissement extra-financiers fondés sur des principes directeurs issus du droit musulman. Ils répondent à une demande ... [more ▼]Les fonds islamiques intègrent dans leur stratégie d’investissement des critères d’investissement extra-financiers fondés sur des principes directeurs issus du droit musulman. Ils répondent à une demande croissante de produits financiers religieusement orientés. Si l’industrie de la gestion d’actifs islamiques se développe sur le marché européen, les fonds islamiques, ainsi que leurs gestionnaires ne font pas l’objet d’une règlementation dédiée. Ils sont par conséquent soumis aux exigences du droit conventionnel des organismes de placement collectif, qui, selon les cas, relèvent du droit européen ou du droit interne des États membres. Pour combler l’indifférence religieuse d’un droit positif aconfessionnel, un cadre normatif spécifique complète le cadre règlementaire étatique. La régulation des fonds islamiques se fait alors par le biais de prescriptions et de recommandations issues de normes autonomes d’origines publiques et privées. Le caractère non-contraignant de ce second ensemble normatif pose la question de l’efficacité juridique de l’encadrement des fonds islamiques. Il interroge également sur l’opportunité, voire la faisabilité d’une norme étatique en la matière. Ce dernier point ne serait-il pas un pré requis nécessaire à la possible émergence d’un modèle (européen) de fonds islamiques permettant de renforcer la protection des investisseurs et l’épanouissement de ce marché ? [less ▲]Detailed reference viewed: 166 (15 UL) Identification of the underlying mechanism of the c.192G>C mutation in the DJ-1 gene and functional characterisation in patient-based cellular models of Parkinson’s disease ex vivoObermaier, Carolin Doctoral thesis (2015)Parkinson’s disease (PD) is the second most common neurodegenerative disease and characterised by a progressive loss of dopaminergic neurons in the substantia nigra pars compacta and in other brain ... [more ▼]Parkinson’s disease (PD) is the second most common neurodegenerative disease and characterised by a progressive loss of dopaminergic neurons in the substantia nigra pars compacta and in other brain regions. Homozygous loss-of-function mutations in the DJ-1 gene (PARK7) are a rare cause of familial early-onset PD. The protein encoded by PARK7 is involved in a variety of biological processes including transcriptional regulation, chaperone-like functions, oxidative stress response and mitochondrial protection. In the present study, we deciphered novel molecular mechanisms underlying the pathogenicity of the c.192G>C DJ-1 mutation previously predicted to lead to a p.E64D amino acid exchange in the DJ-1 protein. To analyse the c.192G>C DJ-1 mutation, we generated and characterised different ex vivo patient-based cellular models including patient-derived primary fibroblasts, immortalised fibroblasts, induced pluripotent stem cells (iPSCs), iPSC-derived small molecule neuronal precursor cells (smNPCs) as well as iPSC-derived midbrain-specific dopaminergic (mDA) neurons. Analyses of DJ-1 expression in these patient-derived model systems from homozygous carriers of the c.192G>C DJ-1 mutation unexpectedly revealed that this mutation leads to the loss of DJ-1 protein in these cell types. Further experiments using qPCR and an in vitro splicing assay showed a splicing defect causing complete skipping of the mutation-carrying exon 3 in the pre-mRNA. After deciphering the pathogenic mechanism, we developed a targeted genetic rescue strategy of the pathological skipping of exon 3. This was performed by using a specific U1 snRNA that specifically binds to the mutated DJ-1 pre-mRNA and allows for the re-induction of physiological splicing. In addition, we extended our strategy by first candidate approaches aiming at a pharmacological rescue that may offer novel causative treatment options in patients carrying the c.192G>C DJ-1 mutation as well as for other diseases caused by the same mutational mechanism. Beyond the molecular genetic characterisation, we developed different patient-based cellular models and addressed the functional effects of loss of DJ-1 protein in different patient-derived cells carrying the c.192G>C DJ-1 mutation (human fibroblasts, iPSC-derived mDA neurons). These analyses revealed mitochondrial impairments upon loss of DJ-1 protein in fibroblasts, including fragmentation and reduced branching of mitochondria as well as a reduced mitochondrial membrane potential compared to healthy controls. The results correlate with our observations in primary cells from DJ-1 knockout mice and support the idea of a conserved role of DJ-1 in maintaining mitochondrial function. Moreover, mDA neurons of the index patient carrying the homozygous c.192G>C DJ-1 mutation showed in-creased lesion rates of mtDNA and no increase in mtDNA copy numbers, suggesting a lack of compensatory capacity. Our data substantially contribute to the understanding of mechanisms and functions of DJ-1 mutations in PD pathogenesis, in particular focusing on mitochondrial phenotypes upon loss of DJ-1 in different human ex vivo models. This underlines the role of DJ-1 as an important key player in the response to oxidative stress and the maintenance of proper mitochondrial function and homeostasis. Overall, we show that the fibroblasts with an inherited c.192G>C DJ-1 mutation, mDA neurons differentiated from iPSCs of these human fibroblasts and the DJ-1 knockout mice constitute excellent knockout model systems to further dissect the role of DJ-1 in neurodegeneration in PD. This also offers human DJ-1 knockout models for future iso-genic control experiments with a restituted endogenous DJ-1 background. Sequentially, it is possible to test whether disease related phenotypes might be rescued by reintroducing DJ-1 or correcting the defective splicing. Finally, the discovery of the underlying mechanism of the c.192G>C DJ-1 mutation opens up novel opportunities for a first genetic and maybe even pharmacological causative treatment for PD. [less ▲]Detailed reference viewed: 178 (23 UL) Migranten in den Medien der europäischen Grenzregion SaarLorLux (1990-2010). Eine vergleichende Inhalts- und DiskursanalyseKreutzer, Elena Doctoral thesis (2015)Aufbauend auf einem aus dem Forschungsstand und seinen Defiziten abgeleiteten Mehrmethodenansatz richtet die Studie von Elena Kreutzer ihren Fokus auf die kulturwissenschaftliche Grenzgebiets-Forschung ... [more ▼]Aufbauend auf einem aus dem Forschungsstand und seinen Defiziten abgeleiteten Mehrmethodenansatz richtet die Studie von Elena Kreutzer ihren Fokus auf die kulturwissenschaftliche Grenzgebiets-Forschung mit Blick auf Medienanalysen. Dabei liegt ihr thematischer Fokus auf der Darstellung von Migranten in den Printmedien Saarbrücker Zeitung, Républicain Lorrain und Luxemburger Wort der als hochgradig interkulturell umschriebenen europäischen Grenzregion SaarLorLux. Die inhalts- und diskursanalytischen Ergebnisse zeigten im Inter-Media-Vergleich folgende Einsichten und Erkenntnisse auf: Einerseits stellten sich über die inhaltsanalytischen Befunde heraus, dass sich die nationalen Systemkontexte in den Medieninhaltsanalysen zu journalistischen Darstellungsmerkmalen, Themenagenden sowie Handlungs- und Aussagenträgern widerspiegeln. Andererseits konnte die Arbeit über die Interdiskursanalyse übergreifende Denkmuster eruieren: Diese wurden in einem gemeinsamen Grundbestand an Kollektivsymbolen und Argumentationsmustern nachgewiesen, der von kulturenübergreifenden, aber dennoch medienspezifischen Elementen ergänzt wurde. Dabei zeigt sich in allen drei Printmedien, dass topische Muster nicht nur defensiv zur Abwehr restriktiver Bestimmungen bzw. Bestätigung vorherrschender Abwehrdiskurse verwendet wurden, sondern zeitweise auch offensiv zur Begründung zuzugs- oder integrationsfavorisierender Maßnahmen. Während auf Basis der Pro- und Contra-Tendenz in der saarländischen und lothringischen Tageszeitung jedoch ein verstärkt problem- und risikoorientierter Blick auf Migration und Migranten ermittelt wurde, richtete die luxemburgische Zeitung ihren Fokus phasenweise auf Potentiale und Ressourcen von Einwanderung und Vielfalt in Luxemburg. Die europäische Grenzregion als Ganzes in Betracht ziehende Zusammenhänge wurden weitgehend mittels grenzüberschreitender Hinweise in Sonderseiten hergestellt. Als Hinweis auf eine grenzüberschreitend kommunizierende Grenzregion genügt dieser Befund jedoch nicht [less ▲]Detailed reference viewed: 152 (19 UL) Mesophilic anaerobic digestion of lignocellulosic substrates under different operating modes and extreme feeding conditions – Optimisation and modellingBenito Martin, Patricia Cristina Doctoral thesis (2015)Detailed reference viewed: 189 (43 UL) Development and Investigation of a New Dry-Stacked Wall SystemAgaajani, Shahriar Doctoral thesis (2015)The present study examines the potential use of a new mortarless and modular masonry system by carrying out its development and performing experimental, numerical, analytical and practical investigations ... [more ▼]The present study examines the potential use of a new mortarless and modular masonry system by carrying out its development and performing experimental, numerical, analytical and practical investigations. Different forms of interlocking masonry elements have been modelled and optimised. Fullscale masonry walls were assembled and tested under compressive, flexural and shear loads. The overall structural behaviour was compared to conventional masonry systems such as hollow and shuttering blocks. The investigations showed overall high structural performances for the developed dry-stacked elements. The effect of the dry joint interfaces were extensively investigated experimentally and numerically under FE analysis. Furthermore, a new numerical technique for the determination of stress-percolation in drystacked load-bearing structures has been developed under numerical computing environment, which supports the better understanding of early fissuring in dry-stacked masonry structures. Finally, based on the experimental observations, a numeric-analytical failure mechanism of the dry-stacked masonry structure is proposed under axial and flexural loading. The completion of the package of dry-stacked units, consisting of interlocking modular masonries and an accompanying array of various other precast parts, confirmed the practical issues and solutions towards the exploitation of the developed dry-stacked elements for the construction of ready-to-build, modular and load-bearing walls. [less ▲]Detailed reference viewed: 463 (45 UL) DNS and Semantic Analysis for Phishing DetectionMarchal, Samuel Doctoral thesis (2015)Phishing is a kind of modern swindles that targets electronic communications users and aims to persuade them to perform actions for a another’s benefit. Miscreants performing this activity are named ... [more ▼]Phishing is a kind of modern swindles that targets electronic communications users and aims to persuade them to perform actions for a another’s benefit. Miscreants performing this activity are named phishers and employ their power of persuasion to tailor socially engineered messages able to deceive their gullible victims. A popular example of phishing activities is the stealing of web services account login information or credit card information using fake websites or spoofed emails. However, several means are used to perform phishing attacks and several goals are sought, which harden the fight against phishing. Despite the forces engaged to get rid of this threat, phishing remains a concerning problem since the financial damage it causes is increasing overtime. Moreover, the perceived fatality about being a victim of phishing erodes the trust among users and threaten the use of electronic means as way of communicating. Existing solutions to cope with phishing attacks are not adapted to their short lifetime and the variety of means used to perform them, making them inefficient. Crowd verified blacklists, emails content analysis techniques or web page content analysis techniques did not succeed to reverse the increasing trend presented by phishing consequences. None of these solutions present the essential requirements that must meet a phishing protection technique to be efficient and which are speed, coverage, reliability and usability. Stating that phishing attacks rely mostly on social engineering and that most phishing vectors leverage directing links represented by domain names and URLs, we introduce new solutions to cope with phishing. These solutions rely on the lexical and semantic analysis of the composition of domain names and URLs. Both of these resource pointers are created and obfuscated by phishers to trap their victims. Hence, we demonstrate in this document that phishing do- main names and URLs present similarities in their lexical and semantic composition that are different form legitimate domain names and URLs composition. We use this characteristic to build models representing the composition of phishing URLs and domain names using machine learning techniques and natural language processing models. The built models are used for several applications such as the identification of phishing domain names and phishing URLs, the rating of phishing URLs and the prediction of domain names used in phishing attacks. All the introduced techniques are assessed on ground truth data and show their efficiency by meeting speed, coverage and reliability requirements. This document shows that the use of lexical and semantic analysis can be applied to domain names and URLs and that this application is relevant to detect phishing attacks. [less ▲]Detailed reference viewed: 294 (12 UL) Deanonymisation techniques for Tor and BitcoinPustogarov, Ivan Doctoral thesis (2015)This thesis is devoted to low-resource off-path deanonymisation techniques for two popular systems, Tor and Bitcoin. Tor is a software and an anonymity network which in order to confuse an observer ... [more ▼]This thesis is devoted to low-resource off-path deanonymisation techniques for two popular systems, Tor and Bitcoin. Tor is a software and an anonymity network which in order to confuse an observer encrypts and re-routes traffic over random pathways through several relays before it reaches the destination. Bitcoin is a distributed payment system in which payers and payees can hide their identities behind pseudonyms (public keys) of their choice. The estimated number of daily Tor users is 2,000,000 which makes it arguable the most used anonymity network. Bitcoin is the most popular cryptocurrency with market capitalization about 3.5 billion USD. In the first part of the thesis we study the Tor network. At the beginning we show how to remotely find out which Tor relays are connected. This effectively allows for an attacker to reduce Tor users' anonymity by ruling out impossible paths in the network. Later we analyze the security of Tor Hidden Services. We look at them from different attack perspectives and provide a systematic picture of what information can be obtained with very inexpensive means. We expose flaws both in the design and implementation of Tor Hidden Services that allow an attacker to measure the popularity of arbitrary hidden services, efficiently collect hidden service descriptors (and thus get a global picture of all hidden services in Tor), take down hidden services and deanonymize hidden services. In the second part we study Bitcoin anonymity. We describe a generic method to deanonymize a significant fraction of Bitcoin users and correlate their pseudonyms with their public IP addresses. We discover that using Bitcoin through Tor not only provides limited level of anonymity but also exposes the user to man-in-the middle attacks in which an attacker controls which Bitcoin blocks and transactions the user is aware of. We show how to fingerprint Bitcoin users by setting an "address cookie" on their computers. This can be used to correlate the same user across different sessions, even if he uses Tor, hidden-services or multiple proxies. Finally, we describe a new anonymous decentralized micropayments scheme in which clients do not pay services with electronic cash directly but submit proof of work shares which the services can resubmit to a crypto-currency mining pool. Services credit users with tickets that can later be used to purchases enhanced services. [less ▲]Detailed reference viewed: 757 (24 UL) Essays on Judgment and Decision Making in AccountingPietsch, Christian Philipp Rafael Doctoral thesis (2015)Detailed reference viewed: 186 (44 UL) Inclusive education from a social-cognitive perspective: Preservice teachers’ explicit and implicit cognitions, judgments of and behavioral intentions regarding immigrant students with special education needsMarkova, Mariya Doctoral thesis (2015)Detailed reference viewed: 101 (13 UL) Étude sur la nature et le régime juridiques des accords judiciaires de coopération internationaleSegovia González, Manuel José Doctoral thesis (2015)Le visage de la coopération judiciaire internationale a depuis un certain temps été bouleversé. Il en est ainsi, par exemple, en matière civile et commerciale. L’actualité atteste l’existence de pratiques ... [more ▼]Le visage de la coopération judiciaire internationale a depuis un certain temps été bouleversé. Il en est ainsi, par exemple, en matière civile et commerciale. L’actualité atteste l’existence de pratiques de coopération judiciaire qui étaient difficilement imaginables autrefois. La coopération entre juges de common law – notamment – va aujourd’hui au-delà des seuls aspects opérationnels des procédures. Les cas de juges coopérant pour résoudre les différends pouvant surgir au cours de leurs procédures sont de plus en plus fréquents. Pour y arriver, ils ont recours à des méthodes parfois peu orthodoxes. Ils dialoguent, communiquent par différents moyens, négocient, voire s’accordent sur la voie à suivre. Cette thèse prétend étudier des accords de coopération entre juges étatiques destinés à résoudre des conflits qui surgissent, ou qui sont susceptibles de surgir, dans le cadre de procédures données. Le phénomène, qui est au cœur de cette nouvelle réalité notamment en matière d’insolvabilité et d’enlèvement d’enfants, ne se présente cependant pas dans des formes connues ou convenues. Il ne se matérialise pas sous la forme des accords qui sont conclus au quotidien. Il relève plutôt d’un rapport qui est particulier à la situation qui engendre les accords. Néanmoins, certains d’entre eux peuvent être qualifiés de contrats. Un contrat de coopération entre juges, conclu dans le cadre d’une affaire donnée, soulève, naturellement, une multitude de questions inédites et fondamentales, les plus importantes portant, peut-être, sur son régime juridique. Sans se vouloir exhaustive, cette étude prétend répondre à certaines de ces questions. Les accords se situant aux confins de différentes branches du droit, l’une de ces questions porte sur leur appartenance à l’ordre juridique international ou à l’un des ordres juridiques des juges contractants, c’est-à-dire à un ordre juridique interne. L’ordre juridique international devant être écarté, l’étude prend de prime abord appui sur les méthodes du droit international privé pour déterminer l’ordre juridique compétent avant de se baser sur le droit administratif afin d’exclure le qualificatif de contrat administratif. Elle offre ainsi une première analyse inédite du régime juridique de ces accords de coopération judiciaire. Cette étude a un caractère résolument prospectif en ce sens qu’elle prend appui sur une pratique qui relève de tribunaux de common law et l’analyse sous l’angle de la tradition continentale. [less ▲]Detailed reference viewed: 211 (21 UL) Optimization of handover procedure between IEEE 802.11 access points under vehicular mobility in an urban environment.Mouton, Maximilien Doctoral thesis (2015)This thesis presents investigations performed on the IEEE 802.11 handover process in order to optimize the exploitation of exisiting IEEE 802.11 networks in vehicular communications. As IEEE 802.11 ... [more ▼]This thesis presents investigations performed on the IEEE 802.11 handover process in order to optimize the exploitation of exisiting IEEE 802.11 networks in vehicular communications. As IEEE 802.11 networks operate over a short range, a mobile station embedded in a vehicle faces frequent handovers leading to long disconnections. This work focused on two objectives. The first was reducing the IEEE 802.11 handover impact such that mobile users are allowed to be fully connected while they stay within the area covered by IEEE 802.11 networks. The second was optimizing the AP selection process in order to comply with the always best connected paradigm by identifying the best access points and the best handover location. These researches lead to the development of a context-based predictive handover mechanism that considers vehicle’s trajectory, road topology, and network deployment information to decide the best handover location and candidate access points. [less ▲]Detailed reference viewed: 59 (10 UL) Understanding primary-school, high-school and university students sustainable behaviours: An approach based on the theory of planned behaviourDe Leeuw, Astrid Doctoral thesis (2015)Developing a more thorough understanding of what motivates young people to adopt sustainable behaviours is an important area of concern that has practical implications for creating sound educational ... [more ▼]Developing a more thorough understanding of what motivates young people to adopt sustainable behaviours is an important area of concern that has practical implications for creating sound educational interventions and ensuring a sustainable future. The overall purpose of this thesis was to assess and understand primary- and high-school students’ environmentally sustainable behaviours in order to inform educational interventions. Moreover, it aimed at analysing one particular socially sustainable behavioural intention among university students, notably their intention to buy fair trade products. The theory of planned behaviour (TPB) was used as the basic theoretical framework to examine these behaviours. We first conducted a pilot study for each behaviour, with the aim to identify salient beliefs of the target populations with regard to the behaviour investigated. Open-ended questionnaires were administered to a sample of 116 primary-school students, 92 high-school students, and 17 voluntary participants at the university level. A content analysis of the participants’ responses allowed the determination of the most salient beliefs, which were used as the basis for the quantitative measures of beliefs in the main studies. The first and second main studies investigated the beliefs of 812 primary-school students and 602 high-school students regarding the adoption of pro-environmental behaviours using a longitudinal approach. The gist of our results seems to be that for both age groups, educational interventions should target control beliefs especially. For instance, students insist on tools that would facilitate pro-environmental behaviours (e.g., having duplex printers or recycling bins at school and at home). However, behavioural and normative beliefs should not be neglected. The last study examined mainly differences in male and female university students’ intentions to consume fair trade products. The results indicate that for women, more emphasis should be placed on perceived behavioural control (e.g., factors that facilitate the ii purchase of fair trade products), while for men, more emphasis should be placed on attitudes towards buying fair trade products (i.e., the advantages of adopting this behaviour). Our results confirm the usefulness of the TPB as a framework for understanding young people’s sustainable intentions and behaviours, with perceived control and attitudes having considerable impacts on sustainable intentions and perceived social pressure having a rather low weight. In addition, perceived control and intentions contributed significantly to the explained variance in primary- and high-school students’ eco-friendly behaviours. This thesis makes a number of important contributions to the literature. From a practical point of view, primary- and high-school students are important populations because sustainability-related habits might be established early in life. Moreover, in their roles as potentially important future decision makers in our society (e.g., future company leaders, politicians, global citizens), university students should be sensitized to the unequal power relationships often involved in conventional trading. Offering fair trade products and encouraging their consumption should be considered a small, but important, step in universities’ duty to create awareness. Despite the positive input for interventions inspired by this thesis, some limitations have to be considered, for instance, our reliance on self-report questionnaires and the possibility that participants may have overestimated the extent to which they perform environmentally and socially desirable behaviours related to sustainability. Last, further research is needed to test the effectiveness of interventions based on the present results. [less ▲]Detailed reference viewed: 135 (11 UL) Provably Secure Countermeasures against Side-channel AttacksVadnala, Praveen Kumar Doctoral thesis (2015)Side-channel attacks exploit the fact that the implementations of cryptographic algorithms leak information about the secret key. In power analysis attacks, the observable leakage is the power consumption ... [more ▼]Side-channel attacks exploit the fact that the implementations of cryptographic algorithms leak information about the secret key. In power analysis attacks, the observable leakage is the power consumption of the device, which is dependent on the processed data and the performed operations.\ignore{While Simple Power Analysis (SPA) attacks try to recover the secret value by directly interpreting the power measurements with the corresponding operations, Differential Power Analysis (DPA) attacks are more sophisticated and aim to recover the secret value by applying statistical techniques on multiple measurements from the same operation.} Masking is a widely used countermeasure to thwart the powerful Differential Power Analysis (DPA) attacks. It uses random variables called masks to reduce the correlation between the secret key and the obtained leakage. The advantage with masking countermeasure is that one can formally prove its security under reasonable assumptions on the device leakage model. This thesis proposes several new masking schemes along with the analysis and improvement of few existing masking schemes. The first part of the thesis addresses the problem of converting between Boolean and arithmetic masking. To protect a cryptographic algorithm which contains a mixture of Boolean and arithmetic operations, one uses both Boolean and arithmetic masking. Consequently, these masks need to be converted between the two forms based on the sequence of operations. The existing conversion schemes are secure against first-order DPA attacks only. This thesis proposes first solution to switch between Boolean and arithmetic masking that is secure against attacks of any order. Secondly, new solutions are proposed for first-order secure conversion with logarithmic complexity (${\cal O}(\log k)$ for $k$-bit operands) compared to the existing solutions with linear complexity (${\cal O}(k)$). It is shown that this new technique also improves the complexity of the higher-order conversion algorithms from ${\cal O}(n^2 k)$ to ${\cal O}(n^2 \log k)$ secure against attacks of order $d$, where $n = 2d+1$. Thirdly, for the special case of second-order masking, the running times of the algorithms are further improved by employing lookup tables. The second part of the thesis analyzes the security of two existing Boolean masking schemes. Firstly, it is shown that a higher-order masking scheme claimed to be secure against attacks of order $d$ can be broken with an attack of order $d/2+1$. An improved scheme is proposed to fix the flaw. Secondly, a new issue concerning the problem of converting the security proofs from one leakage model to another is examined. It is shown that a second-order masking scheme secure in the Hamming weight model can be broken with a first-order attack on a device leaking in the Hamming distance model. This result underlines the importance of re-evaluating the security proofs for devices leaking in different models. [less ▲]Detailed reference viewed: 203 (17 UL) Enabling Testing of Large Scale Highly Configurable Systems with Search-based Software Engineering: the Case of Model-based Software Product LinesHenard, Christopher Doctoral thesis (2015)Complex situations formed by mixes of versatile environments, various user needs and time-to-market constraints led to the development of highly configurable systems. In line with the emergence of such ... [more ▼]Complex situations formed by mixes of versatile environments, various user needs and time-to-market constraints led to the development of highly configurable systems. In line with the emergence of such systems, software development is increasingly moving from the production of a single, yet configurable software to the development of families of software products. Such families of related software are called Software Product Lines (SPLs), and they allow the automation of the configuration, deployment and management of tailored software products through the combination of software features. These features and the constraints defining their legal combinations are usually encoded in a feature model (FM), which is used to represent a SPL. One main challenge with SPLs is testing them, a task which is even more difficult as the number of features proposed is important. Ideally, all the possible products that can be configured from a SPL should be tested. This, however, is unfeasible in practice since only 270 optional features allows configuring more products than the number of atoms in the universe. Considering that realistic SPLs involve thousands of features and that testing capabilities are limited by time and budget constraints, only a subset of all the configurable products can actually be tested, introducing the needs for strategies to test such SPLs. To reduce the testing effort, techniques using combinatorial interaction testing (CIT) have been proposed and proven to be successful. However, they fail at scaling to large and heavily constrained SPLs. In addition, CIT is costly to apply due to the combinatorial explosion induced by calculating the feature combinations. Besides, existing approaches do not consider multiple and potentially conflicting testing objectives such as minimizing the number of configurations and their cost. In this respect, this dissertation introduces scalable techniques for both generating and prioritizing relevant SPL product configurations for CIT by using a similarity heuristic which avoids the combinatorial explosion. In a second step, methods for handling multiple testing objectives are presented. The following part of this thesis focuses on the quality assessment of given product configurations prior to testing. The objective here is to evaluate how good is a given set of configurations according to different testing criteria, whatever the way these configurations have been selected. This situation arises when configurations that have to be tested are already available. Since testing these software products individually is a costly and time consuming task, methodologies to evaluate them prior testing are introduced, thus allowing to discard unnecessary ones and save testing sessions. In particular, an approach based on mutation of the SPL FM which can form viable and cheaper alternative to CIT is presented. The next part of this dissertation investigates the reverse-engineering of a SPL and its FM from existing source code of software product variants. Since SPLs allows us to reduce development costs and quickly derive tailored products for specific market share, automated techniques to migrate similar product variants into a whole SPL are necessary. In particular, the challenge of reverse-engineering a SPL which is concordant with the underlying software products is tackled by a fully automated approach. In addition, since reverse-engineering approaches (whether manually or automatically performed) are inherently error-prone, a methodology for evaluating and fixing reverse-engineered SPL FM is presented. The final part of this dissertation describes the application of the introduced theoretical advances to an industrial case with the CETREL company. In this project, a credit card authorization system is tested by using credit card authorizations. The testing process is optimized by modeling credit card authorizations as a SPL, enabling the application of the above-mentioned generation and evaluation approaches. All the proposed approaches use search-based techniques combined with constraint solvers and have been validated through rigorous experiments performed on moderate to large scale SPLs. [less ▲]Detailed reference viewed: 249 (35 UL) Effect of Endogenous Inhibitors of Tyrosine Kinase Receptors on Glioma Growth: A Role for LRIG1?Horsch Geb. Tiemann, Katja Gertrude Maria Doctoral thesis (2015)Detailed reference viewed: 109 (5 UL) Il principio di non discriminazione e l'identità costituzionale dell'Unione Europea - Le principe de non discrimination et l'identité constitutionelle de l'Union EuropéenneZaccaroni, Giovanni Doctoral thesis (2015)Detailed reference viewed: 111 (6 UL) IN VIVO ANALYSIS OF STEM CELLS AS A PREREQUISITE FOR AUTOLOGOUS CELL REPLACEMENT THERAPIESHemmer, Kathrin Doctoral thesis (2015)The seminal discovery that somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) opens new horizons for future personalised cell replacement therapies. This is particularly ... [more ▼]The seminal discovery that somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) opens new horizons for future personalised cell replacement therapies. This is particularly interesting for neurological disorders since the central nervous system (CNS) possesses only limited regenerative potential and conventional therapies are inefficient. However, the unique feature of pluripotency bears a high risk of tumour formation and therefore restricts the direct utilisation of iPSCs for clinical applications. More recently, direct reprogramming from a somatic lineage into another e.g. into neurons, without passing through the pluripotent state, was achieved, thus circumventing the pluripotency-associated tumorigenic risk. The inability of neurons to self-renew and their restricted lineage potential, however, renders this technique inadequate for routine usage. Conversely, cardinal features of neural stem cells (NSCs) include the ability of self-renewal and trilineage differentiation potential, while their higher degree of differentiation compared to PSCs poses a lower tumorigenic risk. Thus, NSCs possess ideal requirements for neural cell based therapies. However, the features of NSCs under physiological conditions can deviate from their in vitro properties. Therefore, the in vivo features of two novel NSC lines were analysed in the present work in order to assess their relevance for therapeutic applications. The first line analysed, induced NSCs (iNSCs), were directly reprogrammed from mouse embryonic fibroblasts, without passing through the pluripotent state, by using a combination of 4 or 5 transcription factors. These iNSCs closely resemble wild-type NSCs in terms of morphology, gene expression profile, self-renewing capacity, epigenetic status, differentiation potential and functionality. Moreover, in vivo analysis revealed survival ability and multipotent differentiation capacity of the iNSCs. Thus, we proved that differentiated cells can be directly converted to acquire a true NSC identity. Remarkably, the iNSC technique overcomes some of the hurdles associated with PSCs or with induced neurons (iNs), e.g. high tumorigenic potential and inability to self-renew, respectively. In a follow-up study, we analysed the long-term in vivo properties of iNSCs and showed substantial long-term survival rates of grafted iNSCs without graft overgrowth. We further demonstrated neural multilineage differentiation potential of the iNSCs with a clear bias towards astrocytes as well as a permanent downregulation of progenitor and cell cycle markers. These data suggest that iNSCs are not predisposed to tumour formation, making them a safe source for long-term transplantations. Moreover, iNSC-derived progenies fulfil basic requirements to reconstruct damaged tissue i.e. migration, functional integration and interaction with the existing neural circuit, evidenced by the generation of synaptic connections and electrophysiological features. In addition to the murine iNSCs, we also examined multipotent neural precursor cells (NPCs) derived from human PSCs during this thesis. Noteworthy, the generation and propagation of a fully homogeneous neural culture is achieved by using only low-cost small molecules (smNPCs), without tedious manual manipulation and by robust and easy culture conditions. By this means, convenient and affordable large-scale approaches like cell replacement therapies are facilitated. Strikingly, smNPCs uniquely exhibit stable expandability while retaining a broad differentiation potential i.e. the competence to clonally and efficiently differentiate into neural tube-derived CNS lineages as well as neural crest-derived lineages. These features are, so far, only matched by PSCs. The extraordinary features of smNPCs were complemented by their in vivo capabilities: smNPCs possess the competence to survive, to differentiate into mature neurons and astrocytes and to integrate within a physiological neural network without any tumorigenic predisposition. Moreover, smNPCs did not only display a neurogenic differentiation propensity in vivo, but they were also capable of differentiating towards the midbrain dopaminergic (mDA) neuronal subtype in vivo when predifferentiated before transplantation. mDA neurons are of special interest for regenerative approaches to treat Parkinson’s disease (PD). Furthermore, we generated smNPCs from neuroectoderm- and mesoderm-derived iPSCs in order to determine if and to what extend the in vitro as well as in vivo capabilities of smNPCs are influenced by their somatic cell of origin. We found that robust and successful derivation of smNPCs as well as their differentiation potential are not affected by the donor cell type. However, transcriptomic analysis revealed that origin-dependent neural cell identies exist, to a certain degree, in smNPCs in vitro and in vivo though but only to a small extent. Remarkably, these neural cell identities provided certain advantageous features in a physiological neural environment i.e. a better survival rate and neurite outgrowth. Nevertheless, the major in vivo features that are required for the feasibility of successful cell replacement therapies are not restricted by the starting population i.e. robust neuronal differentiation efficiency as well as synapse formation. Overall, this work revealed that iNSCs and smNPCs exhibit important in vivo features that are decisive requirements for the success of future personalised cell replacement therapies. We conclude that not only the iNSC technique itself but also the long-term in vivo features of iNSC progenies render them as a highly desirable tool for glial regenerative therapies, while the multifaceted properties of smNPCs classify them as an extremely qualified tool for neuronal, and in particular mDA neuronal, cell replacement approaches. [less ▲]Detailed reference viewed: 167 (22 UL) The Potential of Precipitable Water Vapour Measurements from Global Navigation Satellite Systems in LuxembourgAhmed, Furqan Doctoral thesis (2015)The primary objectives of this research were to investigate the potential of precipitable water vapour (PWV) estimates derived from Global Navigation Satellite Systems (GNSS) measurements, firstly, for ... [more ▼]The primary objectives of this research were to investigate the potential of precipitable water vapour (PWV) estimates derived from Global Navigation Satellite Systems (GNSS) measurements, firstly, for short-term weather forecasting based on numerical weather prediction (NWP) in Luxembourg and its surroundings and, secondly, for monitoring climate on regional and global scales. The suitability of real-time (RT) zenith total delay (ZTD) estimates obtained from three different precise point positioning (PPP) software packages was assessed by comparing them with the state-of-the-art product from the International GNSS Service (namely the IGS Final troposphere product) as well as collocated radiosonde (RS) observations. It was found that the RT-PPP ZTD estimates from two of the three software packages meet the threshold requirements for NWP nowcasting. The biases between the RT-PPP ZTD and the reference ZTD were found to be stable over time for all the RT-PPP ZTD solutions. A millimetre-level impact on the RT-PPP ZTD estimates was also observed when integer ambiguities were resolved. The impact of assimilating GNSS-derived near real-time (NRT) ZTD in the Applications of Research to Operations at Mesoscale (AROME) NWP model using a three-dimensional, variational (3D-VAR) assimilation scheme on the quality of weather forecasts for Luxembourg was studied. It was found that the assimilation of GNSS-derived ZTD systematically improves the atmospheric humidity short-range forecasts in comparison to other water vapour observing systems (radio soundings, satellite radiances, surface networks). Examination of several case studies revealed the ability of the ZTD observations to modify the intensity and location of predicted precipitation in accordance with previous studies. The addition of ZTD from the dense GNSS network in Wallonie (Belgium) was also found to be beneficial by improving the prediction of rainfall patterns in Luxembourg. The 2D maps of IWV obtained from the hourly NRT system were compared with cloud distribution and precipitation maps from satellite and weather radar data, respectively, and a good agreement in the location of the front system was found. A rise in IWV was recorded during a precipitation event in Luxembourg and it was shown that by observing the IWV change over the ground-based GNSS stations in Luxembourg in NRT, it is possible to determine the speed and direction of the passing fronts and hence storms can also be tracked. A 5-year long global reprocessed GNSS data set containing over 400 ground-based GNSS stations and based on the double differencing strategy has been used to validate the ZTD estimates obtained from the climate reanalysis model of the European Centre for Medium-range Weather Forecasts (ECMWF) namely the ECMWF ReAnalysis-Interim (ERA-Interim) in different climate zones. It was found that the correlation coefficient between the GNSS-derived ZTD observations and the ZTD modeled by ERA-Interim ranges from 0.87 to 1.00. Higher correlation coefficients were found for the stations belonging to the climate zones with lower amount of water vapour. Furthermore, it was found that the mean, SDev and RMS of the differences depends on periodicity in the residuals, altitude of the stations in a particular zone as well as the topographic variation in the zone. Monthly and seasonal means of GNSS-derived ZTD (ZTDgnss) were computed using a global ZTDgnss dataset consisting of 19-years of data and over 400 stations to study the climate variability in different climate zones. In terms of seasonal means, it was found that the climate zones in the northern hemisphere have ZTD maxima in Boreal Summer (June-July-August) whereas those in the southern hemisphere have ZTD maxima in Austral Summer (December-January-February). Monthly and seasonal variability in ZTDgnss was also studied for the locations of 6 ground-based GNSS (SPSLux) stations in Luxembourg. It was found that all the 6 SPSLux stations experience the same monthly and seasonal variability of ZTDgnss. In terms of monthly variation, it was found that the maxima in ZTDgnss occurs around the month of July for all the 6 SPSLux stations whereas in terms of seasonal variation, the location of maxima was found to be in Summer (June-July-August). The suitability of the ZTD derived using precise point positioning (PPP) strategy for climate monitoring applications was studied through its comparison with the ZTD estimates derived using double differenced positioning (DDP) using a global network of 114 stations and duration of 1 year. The mean differences between the two were found to be ranging from -3.35 to 2.37 mm over different climate zones. Furthermore, correlation coefficients ranging from 0.90 and 1.00 were found between the ZTD obtained using the two processing strategies. It was found that use of higher elevation cut-off angles and tropospheric mapping functions based on NWP improves the agreement between the PPP and DDP solutions. [less ▲]Detailed reference viewed: 246 (17 UL) Credit in the Economy: Small Business Default Correlation and Firms' Co-movementsPisa, Magdalena Doctoral thesis (2015)Small businesses play crucial part in every developed economy. They employ about 50% of the workforce and are the engine of innovation. For this reason policy makers and regulators support financing small ... [more ▼]Small businesses play crucial part in every developed economy. They employ about 50% of the workforce and are the engine of innovation. For this reason policy makers and regulators support financing small businesses’ operations to allow them to grow and show its potential. Through a series of studies about small business credit risk, we show that small business credit risk is predominantly related to firm characteristics rather than to economy or industry wide conditions. We find evidence that a distress in a customer industry is linked to higher credit risk among the small business suppliers and that a trade credit is an important channel transmitting distress from one firm to another. [less ▲]Detailed reference viewed: 117 (20 UL) Towards consolidated methods for the design and evaluation of user experienceLallemand, Carine Doctoral thesis (2015)In the “third wave” of Human-Computer Interaction (HCI), the emergence of User Experience (UX) as a key concept has opened up both exciting perspectives and hard challenges. The conceptual shift to a more ... [more ▼]In the “third wave” of Human-Computer Interaction (HCI), the emergence of User Experience (UX) as a key concept has opened up both exciting perspectives and hard challenges. The conceptual shift to a more comprehensive and emotional view of human-computer interactions has been accompanied by the development of numerous methods and tools for the design and evaluation of interactive systems. UX research has thus been mainly driven by novelty and innovation and to date a majority of the developed tools lack validation and consolidation. UX research undoubtedly raises new concerns and challenges common conceptual and methodological practice. Thus the primary objective of this thesis is to contribute to UX consolidation. We addressed this objective by relying on a mixed-methods approach for the empirical part of this thesis, involving comparatively large and representative samples. This part encompasses six studies, representing a variety of perspectives related to UX research consolidation. More specifically, this dissertation includes a replication study (Paper A, N = 758), the translation and validation of a tool (Paper B, N = 381), the development of new design and evaluation methods (Paper C and D, N = 137 and 33), the empirical assessment of the relevance of established HCI methods for the evaluation of UX (Paper E, N = 103) and finally an investigation on how to bridge UX research and practice through a design approach (Paper F). The contributions of this thesis to UX research and practice regard both UX as a concept and its methodologies. Main findings inform about the benefits, challenges, and limitations of UX consolidation strategies as derived from our respective studies (papers A to F). Each study provides advances to both research and practice, while the combination of our studies pushes forward consolidation of UX. This is an essential step with regards to an emerging concept and informs an overarching research agenda aiming at a continuous interdisciplinary fostering of the UX field. [less ▲]Detailed reference viewed: 940 (61 UL) An Event-Driven Cooperative Advanced Driver Assistance System to Mitigate Vehicular Traffic Shock Waves in Temporarily High Traffic DemandForster, Markus Doctoral thesis (2015)In uncoordinated vehicular traffic, available road capacity cannot be fully exploited. This often leads to the formation of traffic jams and the emergence of vehicular traffic shock waves in times of ... [more ▼]In uncoordinated vehicular traffic, available road capacity cannot be fully exploited. This often leads to the formation of traffic jams and the emergence of vehicular traffic shock waves in times of temporarily high traffic demand. The main reason for congestion on highways is the combination of high traffic demand and small instabilities in the flow. These can be caused by bottleneck situations such as ramps, construction sites, accidents, or by small inaccuracies of human drivers. Traffic jams that are caused by the latter reason often are referred to as phantom jams. Even with modern vehicles, equipped with several sensors and driver supporting features, the drivers’ or sensors’ line of sight are already limited by the vehicle ahead. Hence, drivers or vehicles are not able to take anticipatory actions. To overcome these limitations it is necessary to investigate cooperative systems that are connected through a communication channel. In this work, we introduce a novel distributed, connectionless and event-based communication protocol that enables us to eliminate up- stream shock wave formation already with low system penetration rates. Based on traffic information ahead, we propose a Cooperative Advanced Driver Assistance System (CADAS) that recommends pre-emptive velocity reductions in order to redistribute traffic more uniformly thereby eliminating traffic peaks. Simulation results show that our proposed CADAS increases and harmonizes the average velocity, and therewith reduces the overall travel time, avoiding unnecessary slowdowns. We also demonstrate that our event-based messaging scheme uses less network resources than beaconing. Moreover, we conduct a field test on a private test track in order to validate our proposed protocol. We compare uncoordinated traffic to traffic, controlled by the proposed CADAS. With our experiments, we show that such a recommendation-based system can alleviate the formation of vehicular shock waves, thus improve vehicular traffic. Additionally, we perform simulations on the experiment scenario and compare the results to the empirical ones. With this comparison we show that our simulation results agree with the findings from the field test. [less ▲]Detailed reference viewed: 136 (9 UL) Practical Provable Security against Side-Channel AttacksVenkatesh, Srinivas Vivek Doctoral thesis (2015)Securing cryptographic systems in the presence of side-channel leakages is still an important problem. Over recent years, the cryptography theory community has shown considerable interest in formally ... [more ▼]Securing cryptographic systems in the presence of side-channel leakages is still an important problem. Over recent years, the cryptography theory community has shown considerable interest in formally modelling the side-channel leakages and in designing "provably" secure cryptographic primitives in these leakage models. This area is often referred to as leakage-resilient cryptography. Yet, designing a formal model that realistically captures side-channel leakages such as power consumption patterns, and designing primitives efficient enough to be deployed in practice in such a leakage model, remains a challenging research direction. In this work, we aim to bridge the above gap between the theory of provably secure cryptosystems that resist side-channel attacks and their practical relevance. Keeping this goal in mind, we analyze existing constructions and provide new ones for basic cryptographic primitives such as encryption and authentication in both public-key and symmetric-key cryptography. This dissertation consists of three parts. In the first part, we analyze existing and design new efficient leakage-resilient constructions for public-key encryption and digital signatures that tolerate continual leakage in the split-state leakage model. Our security reductions are in the generic bilinear group model. The constructions we consider are simple variants of the ElGamal key encapsulation mechanism, and the Boneh-Boyen and the Schnorr signature schemes. We also cryptanalyze a variant of the ElGamal key encapsulation mechanism that was previously conjectured to be leakage-resilient under certain conditions. The second part of this work is concerned with the protection of block ciphers in the probing adversarial leakage model. This approach, popularly known as masking in the cryptographic engineering community, is an effective countermeasure for block cipher implementations against power-analysis attacks. We improve the efficiency of a generic higher-order masking scheme recently proposed by Carlet et al. Improving the efficiency of this scheme is related to the problem of evaluating polynomials over binary finite fields in a newer cost model that counts only "non-linear" polynomial multiplications. We propose a new method for evaluating polynomials in this cost model, and argue (heuristically) that this method is asymptotically optimal. The third part deals with the construction of efficient leakage-resilient symmetric-key authentication and encryption schemes. The constructions are shown to be secure in the standard model under a recently introduced simulatable leakage assumption. This assumption offers practitioners a hope to work with a formal leakage model that allows empirical verifiability. We propose a leakage-resilient CBC-like message authentication code, and also propose a leakage-resilient PRG-based chosen-plaintext secure encryption scheme for which we quantify the leakage it tolerates during the challenge phase in terms of security of a single iteration. Our constructions tolerate continual leakage but require leak-free updates. [less ▲]Detailed reference viewed: 324 (11 UL) Non-targeted mass isotopolome analysis to gain insights into cancer cell metabolismWeindl, Daniel Doctoral thesis (2015)Detailed reference viewed: 212 (40 UL) Mathematical Modelling of Network TrafficLi, Yu Doctoral thesis (2015)ncreasing access to the Internet is producing profound influence around the World. More and more people are taking advantage of the Internet to obtain information, communicate with each other far away and ... [more ▼]ncreasing access to the Internet is producing profound influence around the World. More and more people are taking advantage of the Internet to obtain information, communicate with each other far away and enjoy various recreations. This largely increased demand for the Internet requires better and more effective models. During the 1990s, a number of studies show that due to a different nature from telephonic traffic, in particular a bursty nature, traditional queuing models are not applicable in modeling of modern traffic. This work presents some alternative rigorous models that can be used in studying the behavior of the Internet traffic. In the thesis, we propose several new models to explain bursty nature of network traffic. Many practical problems in computer science, natural science and insurance are highly complex, since they typically involve a huge amount of random factors. Con- ventional queuing theory cannot handle such problems and the high variance and long memory features are not yet well understood. In the first part of our research, we start with investigation of random sum as well as random product and derive a single path model of network traffic and a multiple path model of network traffic.In the second part of this thesis, we present a homotopic approach to model network traffic. [less ▲]Detailed reference viewed: 147 (13 UL) On dual-polarization signalling techniques in satellite communicationsArend, Lionel Jean Doctoral thesis (2015)In satellite broadcasting and broadband communications, two orthogonal polarizations can be employed for signalling. Typically, two independent carrier signals are transmitted on the horizontal and ... [more ▼]In satellite broadcasting and broadband communications, two orthogonal polarizations can be employed for signalling. Typically, two independent carrier signals are transmitted on the horizontal and vertical linear polarizations. In this way the available frequency spectrum is used twice. Contrary to this independent use, the present work investigates the combined use of both polarizations for signalling and the possibly associated benefits. Two different modulation techniques are investigated. The first, polarization shift keying, modulates the state of polarization of the electromagnetic wave to convey information. It is based on the phase and amplitude relationship between both carriers and is advantageous for channels strongly impaired by phase noise. The second technique defines a four-dimensional signal space for the combined modulation of amplitude and phase on both carriers. It was initially introduced as 4-quadrature signalling and permits transmission with improved power efficiency. Both techniques come from optical fibre communications, where similar propagation conditions exist. The conducted investigation is based on an analysis, simulations and the experimental verification using a specially developed demonstration transmitter and receiver. The simulations compare the power efficiency of the proposed modulation techniques with that of alternatives currently in use and analyse their behaviour upon disturbance by phase noise or non-linear distortion. The demonstrator is used to validate the findings in experimental measurements and to confirm the feasibility of both proposed techniques through a live satellite transmission. [less ▲]Detailed reference viewed: 228 (23 UL) Holocaust-Education in der Luxemburger SchuleGeisler, Nadine Doctoral thesis (2015)Today, the extermination of Jewish communities by the Nazi regime and its collaborators, namely the Holocaust, forms an integral part of the international political agenda. Although this dealing with the ... [more ▼]Today, the extermination of Jewish communities by the Nazi regime and its collaborators, namely the Holocaust, forms an integral part of the international political agenda. Although this dealing with the Holocaust appears normal for us today, this was not always the case, but is the result of extensive social and political processes. In the course of this development the awareness of the special relevance of the extermination of about 6 million Jews has increased. Since the 1990s a process has emerged, that can be characterized as the universalization of Holocaust remembrance. The commemoration of the extermination of the European Jews is no longer an exclusive part of the different national cultures of remembrance, but has become an integral part of international memorial policy. An important event in this context has been the “Stockholm International Forum on the Holocaust” in the year 2000 where mainly European leaders as well as other high-ranking politicians, historians and teachers engaged with Holocaust education, Holocaust remembrance and Holocaust research. The idea was to establish an international organization that would expand Holocaust education worldwide. The aim of the present dissertation is to show how the Luxembourgian school system deals with this traumatic event that is the Holocaust and how it reacts as a system to expectations towards Holocaust and schooling, to find out how the school system works. The dissertation does not address questions as to show how the Holocaust should be taught in schools nor whether or not the Holocaust should be taught in schools at all. The dissertation analyses the particularities of teaching the Holocaust, as well as its role in the curriculum in a broader understanding of an analysis of parliamentary debates, syllabi, teaching material and the school practice. The latter includes the classroom settings and the so-called alternative teaching material like scholarly resources on the Holocaust like films, visits to museums, to concentration and extermination camps or the use of testimony from Holocaust survivors. [less ▲]Detailed reference viewed: 269 (20 UL) Formation of CU(IN,GA)SE2 from Solution Processed Sodium containing Metal PrecursorsBerner, Ulrich Maximilian Doctoral thesis (2015)In this thesis a new chemical deposition process for the fabrication of Cu(In,Ga)Se2 absorber layers applicable as absorber material in thin film solar cells is described. Within this work a power ... [more ▼]In this thesis a new chemical deposition process for the fabrication of Cu(In,Ga)Se2 absorber layers applicable as absorber material in thin film solar cells is described. Within this work a power conversion efficiency of up to 13.3% has been achieved which is among the highest reported values for non-vacuum based processes. The main part of this thesis is divided into 4 chapters describing the synthesis of the base materials and the ink (i), the individual process steps coating and drying together with the metal film formation (ii) as well as the selenization of the metal layer to chalcopyrites (iii). The last chapter investigates the influence of dissolved sodium salts (iv). (i) Metal formates synthesized from their respective nitrates have been chosen as starting salts due to the high reduction potential of the anion and its clean decomposition. With the reasonably toxic solvents tetramethylguanidine and methanol an ink can be produced which is highly concentrated, chemically stable and cheap. (ii) The coating and drying steps have been identified as crucial production processes to deposit homogeneous layers. In this context the solvent mixture has been shown to be responsible for unwanted material agglomerations close to the substrate boundaries. In order to minimize this effect a combined coating-drying device has been developed. The formation of metallic layers has been studied in detail. It could be shown that the respective metal ions are getting reduced consecutively at elevated temperatures between 130 and 200°C. The morphology of the resulting layers is highly dependent on the process conditions and varies from thick and porous structures to incoherent particle agglomerations. In order to overcome this issue an ink additive has been identified to densify and homogenize the metallic layer. A mechanism is proposed based on the formation of an intermediate polynuclear metal organic structure. (iii) The metallic layers could be selenized with elemental selenium in a tube oven to form dense chalcopyrites. By simulating the selenium evaporation a strong dependency of the final photovoltaic cell properties on the process temperature of the substrate layer getting in contact with evaporated selenium could be identified. (iv) Several sodium salts conveniently added to the ink have been proven to be suitable as sodium source. Compared to diffusion from the glass substrate the immediate sodium availability resulted in significantly improved cell properties. Within the evaluated sodium salts large differences have been found for example regarding the layer morphology. [less ▲]Detailed reference viewed: 859 (5 UL) Essays on Credit Risk: European studies in the context of the global financial crisisBekkour, Lamia Doctoral thesis (2015)Given the major role of credit risk in the recent financial crisis, this thesis focuses on analysing different perspectives of credit risk in Europe during the financial crisis. We consider different ... [more ▼]Given the major role of credit risk in the recent financial crisis, this thesis focuses on analysing different perspectives of credit risk in Europe during the financial crisis. We consider different markets: Credit Default Swap (CDS), options on equities and exchange rates, and finally, the equity markets. We also look at the impact on different entities: corporates, banks and sovereigns however, we focus more on banks. [less ▲]Detailed reference viewed: 174 (26 UL) Essays on Sovereign and Banking Credit RiskRasmouki, Fanou Doctoral thesis (2015)In view of growing concerns about financial stability, this thesis revolves over two major objectives. The first objective relates to exploiting option pricing models to generate bank and sovereign credit ... [more ▼]In view of growing concerns about financial stability, this thesis revolves over two major objectives. The first objective relates to exploiting option pricing models to generate bank and sovereign credit risk indicators and is pursued in chapters One and Two. The second objective is about determining the extent to which key institutions, namely the credit rating agencies and the ECB contributed to curing or hampering the European banking system. Chapter Three and Chapter Four address the latter theme. All through this thesis, we lay stress upon the connection between banks and sovereigns. [less ▲]Detailed reference viewed: 109 (7 UL) Aircraft landing gear thermo-tribomechanical model developmentHeirendt, Laurent Doctoral thesis (2015)A transient numerical model for studying the thermo-tribomechanical behavior of an aircraft landing gear is presented. The study reveals the major heat sources and heat sinks that impact the ... [more ▼]A transient numerical model for studying the thermo-tribomechanical behavior of an aircraft landing gear is presented. The study reveals the major heat sources and heat sinks that impact the characteristic thermal behavior of the landing gear shock absorber. The severe in-service performance degradation and reported structural damage can be explained as a consequence of the heat generated by the high drag loads induced by rough runways on the bearings, and by the high sliding velocities of the piston. A conclusive model may lead to improved landing gear performance once the transient process of heat generation in a phase-changing grease-lubricated lower bearing is fundamentally understood. A novel tribotopological lubrication theory is derived in order to take into account all distinct physical phases of the non-Newtonian Bingham lubricant. The governing equations are solved using a hybrid numerical solver that is optimized for numerical efficiency and fast convergence. The proposed framework is validated against existing theories and results, and it demonstrates accurate predictions of the thermal performance of the landing gear. Strategies to passively optimize the lower bearing lubrication mechanism are further suggested in order to achieve optimal thermal performance of future aircraft landing gear. [less ▲]Detailed reference viewed: 29 (3 UL) Property based model checking of structurally evolving Algebraic Petri netsKhan, Yasir Imtiaz Doctoral thesis (2015)There are two important challenges in any system development life cycle, the first is to ensure the correctness of a model at the earliest stage possible and the second is to ensure its correctness once ... [more ▼]There are two important challenges in any system development life cycle, the first is to ensure the correctness of a model at the earliest stage possible and the second is to ensure its correctness once it evolves with respect to the emergence of new requirements, performance may need to be improve, business environment is changing. Usual verification techniques such as testing and simulation are used commonly for the verification of a model. The downsides of these techniques are that there is no guarantee of the absence of errors and they need to be repeated after every evolved version. Model checking is an automatic technique for verifying finite state system models. Although, model checking is proved to be a useful technique, the typical drawback of model checking is its limits with respect to the state space explosion problem. As system gets reasonably complex, completely enumerating their states demands increasing amount of resources. Various techniques like symbolic model checking, on the fly model checking and compositional reasoning partially overcome this problem. Petri net is a well-known low-level formalism for modeling and verifying concurrent and distributed systems. The modeling of systems by low-level Petri nets is tedious and therefore various advancements have been created to raise the level of abstraction of Petri nets. Among others, Algebraic Petri nets raise the level of abstraction of Petri nets by replacing black tokens with the elements of user defined data types i.e., algebraic abstract data types. The first contribution of this thesis is to develop an approach to tackle the state space explosion problem for model checking of Algebraic Petri nets by re-using, adapting and refining state of the art techniques. The proposed approach is based on slicing and the central idea is to perform verification only on those parts that may affect the property the Algebraic Petri net model is analyzed for. We propose several slicing algorithms for Algebraic Petri nets and can be applied to Petri nets by slight modifications. The proposed slicing algorithms can alleviate the state space even for certain strongly connected nets and are proved not to increase the state space. The second contribution is an approach to improving re-verification of structurally evolving Algebraic Petri nets. The idea is to classify evolutions and properties to identify which evolutions require re-verification. We argue that for the class of evolutions that require verification, instead of verifying the whole system, only a part that is concerned by the property can be sufficient. The third contribution is the development of a stand-alone tool i.e., SLAPn. The objective of this tool is to implement proposed slicing algorithms and to show the practical usability of slicing technique. An interesting exploitation of SLAPn is that it can be added to any existing model checker as a pre-processing step. [less ▲]Detailed reference viewed: 188 (18 UL) An Analysis of Legislative Assistance in the European ParliamentPegan, ANDREJA Doctoral thesis (2015)The dissertation ‘An Analysis of Legislative Assistance in the EP’ treats the problem of unelected parliamentary officials, which assist the elected members in the EP. The main research question is how ... [more ▼]The dissertation ‘An Analysis of Legislative Assistance in the EP’ treats the problem of unelected parliamentary officials, which assist the elected members in the EP. The main research question is how does the organisational form of legislative assistance affect the functioning of the EP. The dissertation contributes to a new area of research in legislative studies on the relationship between technocracy and democracy. To gain an insight into the research question, the dissertation is concerned with the institutional design of legislative assistance in two different ways. First, the research project explains the form of legislative assistance in the EP between 1952 and 2013. Second, the dissertation investigates the behavioural consequences (i.e. staff’s frequency of involvement in assistance) of the administrative form in the seventh term (2009-2014). Following these aims, the dissertation is divided into two empirical parts. The qualitative part explains the form of legislative assistance in the EP based on new-institutionalists approaches to organisational design and qualitative methods (content analysis of interview and secondary data). The quantitative part investigates how the form of legislative assistance affects the behaviour of staff based on organisation theory and quantitative methods (PCA/regression). A comparison with the national legislatures reveals that in most aspects the organisation of legislative assistance in the EP resembles the one in state-parliaments, while other aspects are exclusive to the EP. State-parliament characteristics were adopted already in the 1950s due to functional-ideational considerations. Changes were more dynamic in the 1960s/1970s compared to the 1980s/1990s. Until the 1980s, the administrative structures of the EP were responding to political events. Organisational structures significantly determine the frequency staff assist MEPs. To sum up, while the behaviour of staff is conditioned by the organisation of legislative assistance, the organisation itself is conditioned by the historical institutional environment and functional considerations of the EP. [less ▲]Detailed reference viewed: 265 (18 UL) Supporting Stress Testing in Real-Time Systems with Constraint ProgrammingDi Alesio, Stefano Doctoral thesis (2015)Failures in safety-critical Real-Time Embedded Systems (RTES) could result in catastrophic consequences for the system itself, its users, and the environment. Therefore, these systems are subject to ... [more ▼]Failures in safety-critical Real-Time Embedded Systems (RTES) could result in catastrophic consequences for the system itself, its users, and the environment. Therefore, these systems are subject to strict performance requirements specifying constraints on real-time properties such as task deadlines, response time and CPU usage. Lately, RTES have been shifting towards multi-threaded application design, highly configurable operating systems, and multi-core architectures for computing platforms. The concurrent nature of their operating environment also entails that the order of external events triggering RTES tasks is often unpredictable. Such complexity in the system architecture, concurrency, and environment renders performance testing increasingly challenging. Specifically, computing input combinations that are intended to violate performance requirements, i.e., stress testing, is one of the preferred ways for verifying RTES performance. These input combinations are referred to as stress test cases, and, upon execution, are predicted to result in worst-case scenarios with respect to a performance requirement. In RTES, stress test cases are usually characterized by sequences of arrival times for aperiodic tasks in the subject system. Generating stress test cases is challenging because it is hard to predict how a particular sequence of arrival times will affect the system performance, and because the set of all arrival times for aperiodic tasks quickly grows as the system size increases. For this reason, search strategies based on Genetic Algorithms (GA) have been used to find stress test cases with high chances of violating performance requirements. For practical use, software testing has to accommodate time and budget constraints. In the context of stress testing, it is essential to investigate the trade-off between the time needed to generate test cases (efficiency), their capability to reveal scenarios that violate performance requirements (effectiveness), and to cover different scenarios where these violations arise (diversity). Even though GA are efficient, and capable of finding diverse solutions, they explore only part of the search space, and their effectiveness depends on configuration parameters. This aspect justifies considering alternative strategies, such as Constraint Programming (CP), that explore the search space completely. Furthermore, to enable effective industrial application, stress testing has to be capable of seamless integration in the development cycle of companies. Therefore, it is both important to capture specific system and contextual properties in a conceptual model, and to map such conceptual model in a standard Model Driven Engineering (MDE) language such as UML/MARTE. In this thesis, we address the challenges above by presenting a practical approach, based on CP, to support performance stress testing in RTES. Specifically, we make the following contributions: (1) a conceptual model, mapped to UML/MARTE, which captures the abstractions required to generate stress test cases, (2) a constraint optimization model to generate such test cases, and (3) a combined GA+CP stress testing strategy that achieves a practical trade-off between efficiency, effectiveness and diversity. The validation of our work shows that (1) the conceptual model can be applied with a reasonable overhead in an industrial settings, (2) CP is able to effectively identify worst-case scenarios with respect to task deadlines, response time, and CPU usage, and (3) the combined GA+CP strategy is more likely than GA and CP in isolation to scale to large and complex systems. The work in this thesis opens up the exploration of further directions, involving the use of multi-objective optimization to generate stress test cases that simultaneously exercise different performance properties of the system, and of MiniMax analysis to derive design and configuration guidelines that minimize the risk to violate performance requirements at runtime. [less ▲]Detailed reference viewed: 128 (17 UL) Globalisierierung in der Zeitgenossischen Luxemburgischen Literatur - Think Global, Act LocalLakaff, Laura Doctoral thesis (2015)As part of the research project Kulturelle Globalsierung. Kollektivsymboliken in wissenschaftlischen und medialen Globalisierungsdiskursen, initiated by IPSE at the University of Luxembourg, my ... [more ▼]As part of the research project Kulturelle Globalsierung. Kollektivsymboliken in wissenschaftlischen und medialen Globalisierungsdiskursen, initiated by IPSE at the University of Luxembourg, my dissertation shares the opinion that globalization and its effects cannot only be understood and perceived in economics and social sciences. The phenomenon of globalization is influential and international, it has spread throughout all medias and its influences can be found everywhere, for instance in literature. The field of literature becomes the illustration and representation of the effects of globalization. Literature helps to embody abstract constructs as the one of globalization and can thereby illustrate, even explain its manifestations. Literature is a vehicle to transport new ideas, thoughts and trends as it is always a product of its time. The innovation potential of my dissertation is, that I deal specifically with contemporary Luxembourgish literature, a very small and young national literature. By putting my research focus on collective Luxembourgish, I establish an overview of national identity, seen through the eyes of mainly three different Luxembourgish authors: Roger Manderscheid, Jean Portante and Nico Helminger. These three authors have been chosen because of the language they decided to write in: Luxembourgish, German and French, but also because this project will elaborate which literature tools writers use to manifest and illustrate globalization and its features. By having three different perspectives and languages used in Luxembourg, one can show the heterogenic but yet identifying influences of globalization. The differentiated work with a specific national literature helps to capture the collective symbols that all Luxembourgish people as well non-Luxembourgish residents share and can recognize as such. By finding the unifying elements, the differences and dissociative factors can be named and analyzed. This Phd project will help to create a clearer view on Luxembourg, its literature scene and its identity in a modern and globalized world. [less ▲]Detailed reference viewed: 99 (8 UL) Poles Apart : Navigating the Space of Opinions in ArgumentationPodlaszewski, Mikołaj Doctoral thesis (2015)Formal argumentation is a popular reasoning method in knowledge representation for intelligent systems. For the past 20 years it has been based on Dung’s abstract argumentation theory. More recently ... [more ▼]Formal argumentation is a popular reasoning method in knowledge representation for intelligent systems. For the past 20 years it has been based on Dung’s abstract argumentation theory. More recently several challenges have been made to this standard - for example in dynamics and aggregation of argumentation frameworks. To support these new developments in this thesis new foundations are developed based on distance measures. We introduce postulates for distance measures and we show their consistency by constructing concrete measures. In the process we develop the new notion of issue. Subsequently we use the distance measures in argumentation using distance based operators introduced by Miller and Osherson in judgment aggregation. Moreover in this thesis we also improve dialectical proof procedures for grounded semantics and study postulates of non-interference and crash resistance for Dung based non-monotonic inference. [less ▲]Detailed reference viewed: 96 (6 UL) Structural Relaxations in the Rotator Phase of N-EicosaneDi Giambattista, Carlo Doctoral thesis (2015)We present relaxations of the heat capacity of the n-alkane n-eicosane (C20H42) in the metastable rotator phase. These relaxations are not connected to melting but rather to structural changes. A ... [more ▼]We present relaxations of the heat capacity of the n-alkane n-eicosane (C20H42) in the metastable rotator phase. These relaxations are not connected to melting but rather to structural changes. A comparative study of the relaxation times with calorimetry in the time and frequency domain shows a slowing down of the dynamics on approaching the melting temperature of the rotator phase. Relaxation behaviour is also observed in the lattice structure by investigations with X-ray diffraction. It is shown that the angular position of the two most relevant X-ray lines relaxes on different time scales. One of these two relaxations can be related to the relaxations found in calorimetry. The relaxing behaviour is discussed in the framework of conformational defect formation and compared to known phenomena in literature. [less ▲]Detailed reference viewed: 78 (5 UL) How does usability improve computer-based knowledge assessment?Weinerth, Katja Doctoral thesis (2015)There has been a major shift from paper-and-pencil towards computer-based assessments (CBAs). CBA has the potential to overcome various limitations imposed by traditional assessment approaches, mostly ... [more ▼]There has been a major shift from paper-and-pencil towards computer-based assessments (CBAs). CBA has the potential to overcome various limitations imposed by traditional assessment approaches, mostly because CBA allows for the easier and more effective measurement of complex knowledge concepts via the use of dynamic items. Innovative item formats in CBA (dynamic or interactive multimedia items) allow the assessment of complex skills (e.g., complex problem solving), but they also tend to increase the complexity of CBA instruments because of their augmented interactivity. If the CBA is not user-friendly, the test-taker might spend more time and effort trying to understand how to interact with the system instead of focusing on the assessment task itself. The research field of human-computer interaction (HCI) shows that the usability or user-friendliness of the system affects the interaction. Usability addresses how appropriate (for a particular use) or how user-friendly a CBA instrument is. Thus, to the extent that there is any detrimental technical bias in CBA affecting the user-friendliness of a CBA, it will affect the user’s interaction with the instrument and consequently the instrument’s psychometrics. There are certain guidelines (e.g., International Test Commission, 2005) that require usability testing to safeguard against the CBA instrument measuring skills or competencies other than those that are supposed to be measured by the CBA instrument. However, surprisingly little research has been conducted to investigate whether usability has been acknowledged in CBAs and whether researchers are aware of the impact usability might have on the assessment results. To answer these and further research questions, three studies were conducted within this present Ph.D. project. These studies focused on a specific CBA instrument: concept maps. A concept map is a graphical illustration of a knowledge concept and can be described as a “knowledge net.” Research has shown that the concept map is a valid and reliable instrument for measuring conceptual knowledge. Concept map instruments are a good example of the increasing popularity of CBA, as technology allows test-takers to correct and improve their concept maps with ease. Test-takers and their examiners receive immediate feedback on the correctness of the concept map. Furthermore, it is a good example of new approaches to knowledge assessment, which is currently a major trend. All of this taken together makes concept maps a good proxy for new ways of assessing knowledge. Our research builds on three studies (Study I – literature-based study, Study II – laboratory study, Study III – school study) that investigated the impact of usability on computer-based knowledge assessment using concept maps. Study I, a literature-based study, scrutinized the existing literature and answered the fundamental research question of whether and how usability has been acknowledged in CBA concept map studies. As no such literature review existed prior to the current project, a systematic literature review was conducted to shed light on the representation and relevance of usability displayed in CBA concept map studies. The literature review indicated that only 24 of 119 journal articles that assessed computer-based concept maps actually discussed the usability of the applied instrument in some way and only three of those 24 journal articles explicitly mentioned that they evaluated the usability of the applied instruments. The literature review illustrated that usability is rarely acknowledged and reported in CBA concept map studies. Our review brings to light the idea that the impact of usability, although well established in the field of HCI, has received insufficient attention in the field of educational assessment. Study II, a laboratory study, addressed the main research question of how HCI methods can be introduced to the field of educational assessment to improve the usability of a CBA concept map instrument. With a user-centered design and development approach, which makes the user the key reference, usability testing and heuristic analyses were conducted in the usability laboratory. The approved HCI methods of usability testing and heuristic analyses were combined to evaluate and further improve a CBA concept map instrument. We applied three iterative design and re-engineering cycles that were based on the results we received from the usability testing and heuristic analyses. To verify the improvements in the usability of the CBA concept map instrument, three independent and randomly assigned groups of 30 students underwent concept map assessments using the three iteratively developed instruments (baseline (V1), further developed: V2 and V3). The results of this independent design sample study showed that the HCI methods allowed us to design and develop demonstrably usability-improved concept map instruments; they furthermore revealed that the usability improvements significantly improved the assessment outcomes. Study III, a school study, empirically verified the impact that usability has on the psychometrics of the applied CBA instruments and on the satisfaction and performance of the test-takers. The experimental study was conducted at school, and 542 students were randomly assigned to one of the three CBA concept map instruments that showed consecutively improved usability. The performance of the test-takers who worked with the usability-improved instruments significantly increased in comparison with the baseline version. The test-takers indicated that they were more satisfied with the usability-improved instruments. Moreover, the internal consistency of the items from the baseline instrument in comparison with usability-improved instruments increased from a Cronbach’s alpha of .62 to .84. To summarize, Study I showed that the impact of usability is rarely evaluated and discussed in CBA concept map studies. Studies II and III clearly showed that usability has a positive impact on the test-takers’ interaction with the CBA concept map instrument. Specifically, Study II illustrated and demonstrated how HCI methods could be used to achieve usability-improved CBA instruments, which in turn allow for better assessment outcomes. In addition, Study III illustrated that the psychometrics were also affected by the usability of the instrument; specifically, the reliability (measured as the internal consistency of the applied items) increased when the usability-improved instruments were used. Thus, the continuing trend towards CBAs calls for more systematic usability research to help ensure satisfactory psychometric test properties and test-takers’ satisfaction with the instrument. The studies confirmed the hypothesis that if usability is not taken into account, the assessment results may severely compromise the quality of individual diagnostics as well as educational policies and educational decisions. [less ▲]Detailed reference viewed: 156 (35 UL) Do you speak numbers? The relation between language and numerical cognition through the prism of bilingualism and cross-linguistic investigationsVan Rinsveld, Amandine Doctoral thesis (2015)The overarching objective of the thesis was to investigate the link between numbers and language by examining numerical abilities in bilinguals and in cross-linguistic comparisons. I conducted my research ... [more ▼]The overarching objective of the thesis was to investigate the link between numbers and language by examining numerical abilities in bilinguals and in cross-linguistic comparisons. I conducted my research mainly in Luxembourg where the educational context provides a highly standardized framework concerning age of acquisition and performance level achieved in the two school languages German and French. In Luxembourg, it is thus easily possible to directly benefit from very homogenous populations of highly proficient bilingual participants. Consequently this environment provides an exceptionally interesting framework to study numerical cognition and its relation to language. Firstly, two behavioral studies investigated numerical performances (i.e., magnitude judgments and arithmetic problem solving) in bilinguals at progressive stages of their bilingual language acquisition. More specifically, we used both within-subject and between-subject cross-linguistic comparison experimental designs on respectively bilingual and monolingual participants. Secondly, a short cross-linguistic comparison study assessed number transcoding skills in English- and French-speaking children in order to highlight the specific difficulties due to the use of French verbal numbers constructed on vigesimal structures. Thirdly, we adopted a more applied approach with outlooks towards direct educational outcomes for mathematical learning and teaching. We set up an experimental behavioral study that highlighted the importance of language context for efficient arithmetic problem solving in bilinguals’ second language. In a second study, we used a large-scale school assessment dataset to examine language effects on more complex mathematical problem solving. Finally, we used fMRI to identify the neural correlates underlying arithmetic problem solving in bilinguals’ languages and bring additional neuro-scientific insights into the field of language and numbers. [less ▲]Detailed reference viewed: 185 (35 UL) The ex officio doctrine in European consumer law. A procedural tool reinvigorating individual consumer litigationBeka, Anthi Doctoral thesis (2015)The thesis delves into the theoretical underpinnings of the establishment of the powers of national courts to raise pleas of Union consumer law of their own motion and examines the novel dimensions this ... [more ▼]The thesis delves into the theoretical underpinnings of the establishment of the powers of national courts to raise pleas of Union consumer law of their own motion and examines the novel dimensions this opens for individual consumer litigation. In an extensive line of case-law the Court of Justice has built the principle of an active court in individual consumer litigation around the concepts of effectiveness of mandatory rules of consumer law and weaker party protection. Such understanding of judicial powers has been formulated, in certain circumstances, independently from the respective national procedural rules. The thesis analyses the question in terms of a Union consumer ex officio doctrine, presents its implications from a civil justice perspective and its important contribution for the effective judicial protection of consumers and Union citizens. [less ▲]Detailed reference viewed: 519 (44 UL) Electrodeposition of Chalcopyrites from Deep Eutectic Based Ionic LiquidsMalaquias, Joao Corujo Branco Doctoral thesis (2015)This thesis focuses on the electrodeposition of metal precursors from a deep eutectic based ionic liquid electrolyte and their annealing for Cu(In,Ga)(S,Se)2 thin film solar cells. Ionic liquids are ionic ... [more ▼]This thesis focuses on the electrodeposition of metal precursors from a deep eutectic based ionic liquid electrolyte and their annealing for Cu(In,Ga)(S,Se)2 thin film solar cells. Ionic liquids are ionic compounds which are liquid at temperatures below 100 °C and contain no water. Therefore, by using an ionic liquid electroplating bath, the electrolysis of water is avoided and elements which are normally difficult to electrodeposit, such as gallium, can be easily deposited. In this sense, the electroplating current efficiency of the process (i.e. the energy efficiency of the process) is significantly improved by using an ionic liquid electrolyte instead of an aqueous electroplating bath. The objectives of this work are i) to electrodeposit Cu(In,Ga) metal precursors with high electroplating current efficiency, ii) to control the chemical composition of these precursors and iii) form Cu(In,Ga)(S,Se)2 absorber layers with adequate chemical composition and morphology for solar cell fabrication. In the frame of the third objective, it is intended to obtain absorber layers with a continuous gallium distribution as well. This last point is due to the fact that, during thermal annealing of metal precursors, gallium often segregates to the back of the absorber layer. Ultimately, this uneven gallium distribution can hinder the performance of solar cells. To meet these objectives, the co-electrodeposition of a) copper and indium, b) indium and gallium and c) copper, indium and gallium from an ionic liquid electrolyte is studied. The ionic liquid used in this work results from the 1:2 molar mixture of choline chloride and urea. From this work, the electrodeposition of Cu(In,Ga) metal precursors with an electroplating current efficiency above 75% was achieved. It was observed that the morphology of the electrodeposited precursors depended on the chemical composition of the electrolyte. In this frame, Cu(In,Ga) layers with dendritic or compact morphology were obtained. Precursors with dendritic morphology are not adequate, since this morphology persists after thermal annealing and ultimately results in devices with no efficiency. The chemical composition of the metal precursors can be controlled as well. Specifically, the gallium content of the metal precursor, which influences the optoelectronic properties of the absorber layer, was accurately tuned. The gallium content is usually expressed as the concentration ratio [Ga]/([Ga]+[In]) and could be tuned between 0.1 and 0.9. Therefore, the electrodeposition of Cu(In,Ga) metal precursors with high gallium content was achieved for the first time and would not have been possible without the use of an ionic liquid electrolyte. After subjecting the metal precursors to a thermal annealing, absorber layers with adequate chemical composition and morphology were obtained. Additionally, by employing a specific annealing routine developed at the Institute of Energy Conversion in the University of Delaware, absorbers with a continuous gallium profile and different gallium contents were obtained. It was observed that the performance of the solar cells was limited by the thermal annealing step and a maximum solar cell efficiency of 9.8% was achieved. In general, it can be concluded that different precursors require different thermal annealing routines in order to form quality absorber layers. [less ▲]Detailed reference viewed: 179 (19 UL) On-ground Signal Processing Techniques Enabling Efficient Amplification of Multiple Carriers in Satellite ChannelsPiazza, Roberto Doctoral thesis (2015)Detailed reference viewed: 95 (11 UL) Fingerprinting Techniques for Network SecurityLanze, Fabian Doctoral thesis (2015)Fingerprinting techniques aim to identify objects such as devices, data, users, or even attacks, based on distinctive characteristics. The goal of this thesis is to de- velop and evaluate methods for ... [more ▼]Fingerprinting techniques aim to identify objects such as devices, data, users, or even attacks, based on distinctive characteristics. The goal of this thesis is to de- velop and evaluate methods for fingerprinting in different application domains and to contribute to a better understanding of fingerprinting in general. We concentrate on approaches that are applicable in practice to improve the security of computer networks. We first introduce a novel formal model of the central concepts of finger- printing in order to relate techniques to their particular application scenario. This model allows the comparison of approaches and the evaluation of their effectiveness for practical use. The evil twin attack in 802.11 networks is a severe security problem that nei- ther the industry nor the research community has found appropriate solutions for. Motivated by this threat, we develop novel fingerprinting methods. We address this challenge from two angles. In our first approach we exploit minuscule yet observable inaccuracies in crystal-oscillator-driven computer clocks. We will show that several conclusions drawn in the related research about the efficacy of this fingerprinting feature are false. We then enhance state-of-the-art approaches and for the first time provide a solution for remote physical device fingerprinting performed by typical off-the-shelf client devices that is able to mitigate the evil twin threat in practice. The second approach focuses on fingerprinting the behavioral characteristics of soft- ware tools that have been developed or can be misused to mount the attack. As we will show, our fingerprinting methods, which primarily exploit unavoidable low-level characteristics, allow the reliable detection of such an attack strategy within a few seconds. We then switch the perspective to the attacker’s side and investigate a finger- printing method that has been proposed to attack anonymization networks such as Tor by using traffic analysis, commonly referred to as website fingerprinting. We propose a novel approach that outperforms state-of-the-art methods in this area. We then evaluate for the first time the practical applicability of website fingerprinting in a realistic scenario, while avoiding simplified assumptions predominantly made in the related research. Our evaluation indicates that this particular threat, which is considered to be a serious security problem affecting many users, is not as severe as presumed. Therefore, concerns that have been raised and strategies for circumvent- ing this attack that have been proposed need to be reconsidered. [less ▲]Detailed reference viewed: 288 (27 UL) Receiver Antenna and Empirical Multipath Correction Models for GNSS SolutionsSidorov, Dmitry Doctoral thesis (2015)The advent of the Global Navigation Satellite Systems (GNSSs), in particular, the U.S. Global Positioning System (GPS) and the Russia's GLObalnaya NAvigatsionnaya Sputnikovaya Sistema (GLONASS) have ... [more ▼]The advent of the Global Navigation Satellite Systems (GNSSs), in particular, the U.S. Global Positioning System (GPS) and the Russia's GLObalnaya NAvigatsionnaya Sputnikovaya Sistema (GLONASS) have revolutionized geodesy by enabling a cheap and robust way of providing precise and continuous position estimates to users. Moreover, GNSSs have been shown to be extremely useful for a wide variety of other applications, in particular, geophysical, atmospheric, oceanographic studies, as well as industrial applications. Although the last two decades of GNSS exploitation were marked by great advances in accuracy and precision of the involved techniques, improvements can still be made. This thesis addresses the topic of receiver antenna and empirical multipath correction models, aiming to further improve GNSS solutions. GNSS utilizes measurement of ranges between satellites orbiting the Earth and receivers located on the Earth's surface through modulated electromagnetic signals. However, the actual point where the signal is received and which is denoted as a phase centre of an antenna, is not fixed, but varies depending on many parameters. Therefore, high-precision GNSS fundamentally depends on antenna phase centre corrections (PCC) and failing to accurately apply the latter results in biases and elevated uncertainties of estimated GNSS solutions. Additionally, due to repeating satellite-receiver geometry, these phase centre modelling deficiencies may lead to the generation of harmonic signals in the time series of the estimated parameters. In turn, identifying geophysical signals in the time series may be compromised by the presence of these artificial signals, resulting in inaccuracies in derived models. The geodetic community employs averaged (type-mean) PCC to estimate GNSS orbits, clock biases, tropospheric delays and other parameters, as well as to realize and provide access to the terrestrial reference frame. However, the use of individual PCC is beneficial for GNSS solutions, as it allows for more accurate estimation of satellite orbits and ground station coordinates. The latter is demonstrated using a regional network of 55 GNSS stations and processing the GPS data over a period of 10 years. Another topic addressed in this thesis concerns development of empirical site models (ESMs) using post-fit phase residuals accumulated over a period of time. These models are aimed to mitigate multipath and other unmodelled site effects that have a negative impact on GNSS solutions. Using a global network of stations the derived ESMs are evaluated for their capability to improve the GPS orbit determination as well as to increase the accuracy of ground station coordinate estimation. [less ▲]Detailed reference viewed: 136 (18 UL) Le fait internationalement illicite dans le temps: une question de procédure et de fond entre formalisme et activisme judiciaireKomaïti, Maria-Vasileia Doctoral thesis (2015)Le fait internationalement illicite constitue l’objet d’appréciation de la juridiction internationale en vue de l’engagement de la responsabilité étatique. Or, la diversité des cas litigieux peut résulter ... [more ▼]Le fait internationalement illicite constitue l’objet d’appréciation de la juridiction internationale en vue de l’engagement de la responsabilité étatique. Or, la diversité des cas litigieux peut résulter en une diversité de solutions et une flexibilité à l’approche du juge international. Cette souplesse s’illustre dans le dipôle entre formalisme et activisme judiciaire. Comme le pouvoir du juge ou arbitre international est conféré après consentement étatique au mécanisme judiciaire, il peut être rétréci selon une approche axée formellement sur le consentement étatique ou dilaté selon une approche fondée amplement sur d’autres critères. Un aperçu global sur le fond du comportement étatique est indispensable pour délimiter la violation internationale, la compétence de la juridiction internationale, définie principalement dans une phase préliminaire de la procédure, étant affectée. En particulier, l’argument de l’existence d’une violation continue qui persiste au moment de l’appréciation de l’affaire offre à la partie demanderesse la possibilité de contourner les règles régissant la procédure internationale. Parfois le concept de la violation continue peut être fictif, une pure invention théorique qui ne concourt qu’à l’insécurité juridique. Ainsi, le risque d’un excès du pouvoir juridictionnel est réel. Devant ce risque, l’étude essaie d’encadrer tant la constatation d’une violation internationale continue et sa réalisation que la compétence juridictionnelle pour la connaître ou la prendre en considération. Elle tente de dresser le contexte des concepts principaux, poser des critères différenciant l’instantanéité de la continuité de la violation et de fixer ses limites extrêmes. En plus, elle essaie d’identifier les conséquences de l’existence d’une violation continue sur l’engagement juridictionnel et, par conséquent, sur le pouvoir juridictionnel, dans une phase tant préliminaire que finale de la procédure internationale pour finalement examiner l’existence des méthodes alternatives afin que l’efficacité de la protection internationale ne soit pas compromise en raison de la sécurité juridique. [less ▲]Detailed reference viewed: 102 (7 UL) Die Familiennamen im historischen luxemburgischen Raum. Eine quantitative und qualitative Analyse der onymischen Grenzen und RaumstrukturenFlores, Amaru Doctoral thesis (2015)Detailed reference viewed: 173 (15 UL) Sprachkontaktinduzierte Variation im luxemburgischen KonsonantismusConrad, François Doctoral thesis (2015)The young Luxembourgish language shows a strong contact with neighbouring French and German. The analysis of variation patterns in words that can be described as “phonological doublets” – words with a ... [more ▼]The young Luxembourgish language shows a strong contact with neighbouring French and German. The analysis of variation patterns in words that can be described as “phonological doublets” – words with a variable pronunciation, either in a ‘French’ or ‘German’ way – revealed that the influence of French on the (linguistic) structure of Luxembourgish is decreasing, while nativization processes and the raising influence of German increases the similarities between Luxembourgish and German at the phonetic-phonological level. As the comparison of three generations shows, this change happened over some 60 years only, with the elder generation using more variants close to the French pronunciation (e.g. [s]ymbol, Organisa[sj]oun), whereas the younger generation uses more variants close to the German pronunciation (e.g. [z]ymbol, Organisa[tsj]oun). The data gathered in a three-step experiment (translation from French and German into Luxembourgish, reading task, self-evaluation task) further revealed the flexibility of the Luxembourgish phonological system, strongly influenced by and converging to the French/German pronunciation in the translation task. Finally, the competences of the speakers in the neighbouring languages play another key role in explaining the choice of the variants, whereas the self-evaluation task showed that the variation is in many cases not conscious to the speakers. The study of language contact involving three (not only two, as in many other studies) languages gives new insights in the ways of which one language can influence another one, while the chosen quantitative/statistical framework (variable rule program following William Labov) revealed itself very constructive in the analysis of variation patterns in Luxembourgish. In a broader linguistic view, the results show the plenitude of new linguistic insights that can be found through the study of Luxembourgish, a language which can only be fully understood by consideration of the neighbouring languages as well. [less ▲]Detailed reference viewed: 244 (23 UL) Reconstruction of IRG1 Gene Regulatory Network in Mammalian Macrophages under Inflammatory ConditionsTallam, Aravind Doctoral thesis (2015)The immune system is the first line of defence against invading pathogens. Macrophages are the key effector cells of the innate immune system which produce an array of cytokines, antimicrobial peptides ... [more ▼]The immune system is the first line of defence against invading pathogens. Macrophages are the key effector cells of the innate immune system which produce an array of cytokines, antimicrobial peptides, and effector molecules pathogen in response to pathogen invasion. Immunoresponsive gene 1 (Irg1) is highly upregulated when mouse macrophages are stimulated with LPS. Recently, the function of Irg1 has been elucidated as a gene coding for a protein which catalyses the decarboxylation of cis-aconitate, a tricarboxylic acid (TCA) cycle intermediate, to itaconic acid. In turn, itaconic acid selectively inhibits isocitrate lyase, a key enzyme of the glyoxylate shunt, which is a saviour pathway for bacteria to grow on low carbon diets. Thus, Irg1 via the production of itaconic acid plays an important role in combating pathogen invasion. Despite the importance of this recent discovery, the upstream transcriptional machinery of IRG1 has not yet been investigated. Hence, the aim of this thesis was to elucidate the gene regulatory networks of IRG1 in mammalian macrophages under inflammatory conditions. To achieve this aim, the experimental protocols for the isolation of monocytes from peripheral blood and their differentiation into macrophages were implemented. The cells were then characterised based on their morphology and the expression profile of cellular marker genes to confirm their identity. Using this cellular model, I discovered IRG1 expression and itaconic acid production in human macrophages under LPS activation. Both IRG1 and itaconic acid were initially discovered elsewhere in murine macrophages upon LPS stimulation. I further analysed the dynamics of IRG1 expression and itaconic acid production using different bacterial and viral ligands in human and mouse macrophages, showing that IRG1 expression could be upregulated when mammalian cells encounter bacteria and viruses. Owing to the complex upstream transcriptional machinery for IRG1 expression, I implemented a workflow defined as transcription factor identification protocol (TFIP) using both experimental and computational methods to identify potential transcription regulators for IRG1 expression in human and mouse macrophages. siRNA mediated gene silencing experiments in human and mouse macrophages revealed IRF1 as a transcriptional regulator for IRG1 in both the species and CEBPB in mouse macrophages under LPS activation. [less ▲]Detailed reference viewed: 177 (43 UL) Confnement effects on a low molecular weight liquidDjemour, Anna Doctoral thesis (2015)Investigation of the confinement of the epoxy resin DGEBA in nanopores using DSC, TMA and DS.Detailed reference viewed: 110 (10 UL) Energetisches Regionalisieren. Transformationspraktiken der Energiewende am Beispiel der BiogaserzeugungFaller, Fabian Doctoral thesis (2015)This doctoral dissertation examines geographical dimensions of the energy transition. It develops a conceptual framework for practice oriented transition studies in economic geography. Therefore, the ... [more ▼]This doctoral dissertation examines geographical dimensions of the energy transition. It develops a conceptual framework for practice oriented transition studies in economic geography. Therefore, the energy transition is conceptualised as a socio-technical phenomenon and as a result of various practices. These practices (re)produce and transform the spatial contexts in which energy is produced and consumed. The main focus lies on the shift to renewable energies in so-called “energy regions”. There, various actors are involved in the operation of renewable energy facilities, such as operators, plant manufacturers, maintenance companies, planners, politicians, or local residents. The dissertation in hand illuminates the space-time dimension of these actors’ interplay, how their practices change over time and thereby constitute energy regions. The case of biogas co-fermentation exemplifies this “energetic regionalising”. Central findings are first, that knowledge exchange and creation of routines are central for regionalisations in the biogas sector. Second, in the case of renewable energies, different spatial concepts unfold meaning: Euclidian space as locale of resources, technologies and social discourse; relational space as platform for knowledge exchange as well as the creation and diffusion of routines, values and norms – that are embodied in practices of regionalisation. And third, regionalisations can be understood as practices and processes that contribute to the creation and stabilisation economic sectors. [less ▲]Detailed reference viewed: 182 (38 UL) Energiee zienz, Nutzerkomfort und Kostenanalyse von Lüftungsanlagen in Wohngebäuden: Feldtests von neuen Anlagen und Vorstellung bedarfsgeführter PrototypenMerzkirch, Alexander Doctoral thesis (2015)Detailed reference viewed: 110 (16 UL) DES INÉGALITÉS SOCIALES AUX DÉCÈS PAR SURDOSE AU SEIN DES USAGERS DE DROGUES ILLICITESOriger, Alain Doctoral thesis (2015)Illicit and licit drugs’ misuse poses a serious threat to the health, safety and well-being of mankind. Social and health correlates of drug misuse are numerous and many of these can be reduced or avoided ... [more ▼]Illicit and licit drugs’ misuse poses a serious threat to the health, safety and well-being of mankind. Social and health correlates of drug misuse are numerous and many of these can be reduced or avoided by improved prevention and intervention strategies. Our research analyses the association between socioeconomic inequalities and drug-related mortality. Four complementary studies have been conducted and the following results are to be stressed. Absolute national prevalence and prevalence rates of problem drug users have been increasing between 1997 and 2000 and declining from 2003 onwards. Luxembourg, with 6.16 problem drug users per 1,000 inhabitants aged between 15 and 64 years, is ranking among the 5 Member states showing the highest prevalence within the EU. In terms of drug-related mortality, 1.7 and 2.2 acute overdoses per 100,000 inhabitants have been registered nationally in 2011 and 2012, respectively. At EU level, Luxembourg stood for one of the highest fatal overdose rates in 2000, whereas in 2009 its prevalence fell below the EU average rate. Gender revealed to be a risk factor of drug-related mortality. We showed that the burden of deaths caused by fatal overdoses on the general national mortality was significantly higher for men compared with women. However, it appeared that female overdose victims whiteness remarkably different drug use patterns and trajectories than their male peers. Also, the time window between the onset of illicit drug use and its fatal outcome revealed to be shorter for women versus men included in our study. Early intervention in female drug users, routine involvement of first line health care providers and increased attention to poly- and psychotropic prescription drugs’ use might contribute to preventing premature drug-related death and reducing gender differences. Social and economic status of drug users impact on the occurrence of fatal overdoses. However, actual and self-referred socioeconomic characteristics of drug users may have a greater predictive value than the parental socioeconomic situation. Individual socioeconomic achievements seem to be more determinant in this context than trans-generational social status baggage. Our results suggest that measures aiming at improving educational levels, promoting vocational training and facilitating socio-professional (re)integration of drug users should, beyond their general objective of social insertion, completing conventional harm reduction strategies in order to increase their impact on public health, and eventually on the prevention of drug-related mortality. Our final study explored the cumulative effect of socioeconomic disadvantages on the probability of dying from an overdose of illicit drugs. Results showed that the risk of fatal overdoses increases proportionally with the accumulation of socioeconomic disadvantages and that, likewise in general morbidity and mortality, a social gradient seems also to be at stake when it comes to overdose-related mortality. These results suggest that any measure aiming at reducing social disparities may have a positive and dynamic impact that, even if isolated or targeted, counter the negative cumulative effect in terms of survival. Harm reduction services should integrate socially supportive offers, not only because of their general aim of social reintegration but crucially in order to meet their most important objective, that is to reduce drug-related mortality. This said, social parameters should not be seen as independent determinants and even more so should the concept of social inequalities be widened when applied to drug-related mortality. Although, the social status seems to hold a major role here, family, social and societal environments, as well as migration and acculturation contexts, also with a view on gender disparities, are at play in the attempt to explain differences in terms of morbidity and mortality. The future challenges for research will lie in the capacity to take into account the various demographical and societal mutations that next generations will experience and the way they will, or will not, succeed to share resources and distribute wealth in a ‘ healthy ’ way. [less ▲]Detailed reference viewed: 128 (8 UL) The composite semiotics of interactional repair in French and Italian TV debatesAlbanese, Claudia Doctoral thesis (2015)In this work, the composite semiotics of interactional repair is analysed across n=409 tokens of different repair types in French and Italian TV debates. Three methodologies are merged to understand if ... [more ▼]In this work, the composite semiotics of interactional repair is analysed across n=409 tokens of different repair types in French and Italian TV debates. Three methodologies are merged to understand if variables correlate on the contextualisation of repair and how. Talk in interaction is transcribed and analysed following conversation analytic methods (Sacks et al., 1974). Acoustic analysis is run to detect average means, minimum and maximum pitches movements (Boersma and Weenink, 2014). Facial action units of the upper face are transcribed following the FACS methodology (Ekman and Friesen, 1983 and Ekman et al., 2002). In the datasets sampled, both French and Italian speakers produce AU 1+2 more often than other movements. The duration of facial action units is also considered. Action units (AU) below 500 ms and above 500 ms are distinguished. According to previous literature (Ekman, 1969), movements below 500 ms are involuntary. Data show that both in French and Italian, AUs are more frequently shorter than 500 ms on speech errors, cut offs, and edits and more frequently longer than 500 ms on recyclings and replacements. The movements preceding and following the AU in analysis are also analysed. When AUs at AU-1 and AU+1 differ in configuration or drastically in intensity with respect to the AU in analysis, the AU is said to be in prosodic break with respect to its surroundings thus a cue to the contextualisation of the action it accompanies usually a repair (or an increment repair). In n=409 instances of repair analysed, n=174 AUs in analysis are in prosodic break with both AU-1 and AU+1, and in half of these instances a maximal pitch accent correlates too. [less ▲]Detailed reference viewed: 101 (14 UL) BALANCING NON-FUNCTIONAL REQUIREMENTS IN CLOUD-BASED SOFTWARE: AN APPROACH BASED ON SECURITY-AWARE DESIGN AND MULTI-OBJECTIVE SOFTWARE DYNAMIC MANAGEMENTEl Kateb, Donia Doctoral thesis (2015)Beyond its functional requirements, architectural design, the quality of a software system is also defined by the degree to which it meets its non-functional requirements. The complexity of managing these ... [more ▼]Beyond its functional requirements, architectural design, the quality of a software system is also defined by the degree to which it meets its non-functional requirements. The complexity of managing these non-functional requirements is exacerbated by the fact that they are potentially conflicting with one another. For cloud-based software, i.e., software whose service is delivered through a cloud infrastructure, other constraints related to the features of the hosting data center, such as cost, security and performance, have to be considered by system and software designers. For instance, the evaluation of requests to access sensitive resources results in performance overhead introduced by policy rules evaluation and message exchange between the different geographically distributed components of the authorization system. Duplicating policy rule evaluation engines traditionally solves such performance issues, however such a decision has an impact on security since it introduces additional potential private data leakage points. Taking into account all the aforementioned features is a key factor to enhance the perceived quality of service (QoS) of the cloud as a whole. Maximizing users and software developers satisfaction with cloud-based software is a challenging task since trade-off decisions have to be dynamically taken between these conflicting quality attributes to adapt to system requirements evolution. In this thesis, we tackle the challenges of building a decision support method to optimize software deployment in a cloud environment. Our proposed holistic method operates both at the level of 1) Platform as a service (PaaS) by handling software components deployment to achieve an efficient runtime optimization to satisfy cloud providers and customers objectives 2) Guest applications by making inroads into the design of applications to enable the design of secure systems that also meet flexibility, performance and cost requirements. To thoroughly investigate these challenges, we identify three main objectives that we address as follows: The first objective is to achieve a runtime optimization of cloud-based software deployment at the Platform as a service (PaaS) layer, by considering both cloud customers and providers constraints. To fulfill this objective, we leverage the models@run.time paradigm to build an abstraction layer to model a cloud infrastructure. In a second step, we model the software placement problem as a multi-objective optimization problem and we use multi-objective evolutionary algorithms (MOEAs) to identify a set of possible cloud optimal configurations that exhibit best trade-offs between conflicting objectives. The approach is validated through a case study that we defined with EBRC1, a cloud provider in Luxembourg, as a representative of a software component placement problem in heterogeneous distributed cloud nodes. The second objective is to ameliorate the convergence speed of MOEAs that we have used to achieve a run-time optimization of cloud-based software. To cope with elasticity requirements of cloud-based applications, we improve the way the search strategy operates by proposing a hyper-heuristic that operates on top of MOEAs. Our hyper-heuristic uses the history of mutation effect on fitness functions to select the most relevant mutation operators. Our evaluation shows that MOEAs in conjunction with our hyper-heuristic has a significant performance improvement in terms of resolution time over the original MOEAs. The third objective aims at optimizing cloud-based software trade-offs by exploring applications design as a complementary step to the optimization at the level of the cloud infrastructure, tackled in the first and second objectives. We aimed at achieving security trade-offs at the level of guest applications by revisiting current practices in software methods. We focus on access control as a main security concern and we opt for guest applications that manage resources regulated by access control policies specified in XACML2. This focus is mainly motivated by two key factors: 1) Access control is the pillar of computer security as it allows to protect sensitive resources in a given system from unauthorized accesses 2) XACML is the de facto standard language to specify access control policies and proposes an access control architectural model that supports several advanced access requirements such as interoperability and portability. To attain this objective, we advocate the design of applications based on XACML architectural model to achieve a trade-off between security and flexibility and we adopt a three-step approach: First, we identify a lack in the literature in XACML with obligation handling support. Obligations enable to specify user actions that have to be performed before/during/after the access to resources. We propose an extension of the XACML reference model and language to use the history of obligations states at the decision making time. In this step, we extend XACML access control architecture to support a wider range of usage control scenarios. Second, in order to avoid degrading performance while using a secure architecture based on XACML, we propose a refactoring technique applied on access control policies to enhance request evaluation time. Our approach, evaluated on three Java policy-based systems, enables to substantially reduce request evaluation time. Finally, to achieve a trade-off between a safe security policy evolution and regression testing costs, we develop a regression-test-selection approach for selecting test cases that reveal faults caused by policy changes. To sum up, in all aforementioned objectives, we pursue the goal of analysing and improving the current landscape in the development of cloud-based software. Our focus on security quality attributes is driven by its crucial role in widening the adoption of cloud computing. Our approach brings to light a security-aware design of guest applications that is based on XACML architecture. We provide useful guidelines, methods with underlying algorithms and tools for developers and cloud solution designers to enhance tomorrow’s cloud-based software design. Keywords: XACML-policy based systems, Cloud Computing, Trade-offs, Multi-Objective Optimization [less ▲]Detailed reference viewed: 267 (51 UL) Design of point fitted insulating glass unitsTibolt, Mike Doctoral thesis (2015)Today’s building façades are not imaginable without the building material glass. Modern architects capitalise the transparency and the load carrying capacity of glass elements in the design of filigree ... [more ▼]Today’s building façades are not imaginable without the building material glass. Modern architects capitalise the transparency and the load carrying capacity of glass elements in the design of filigree and light-flooded structures. Priority is thereby given to the maximal transparency and the energy efficiency of the glass façade. In fact, the strategy paper “EU 2020” formulated by the European Union has an important impact on the design of glass façade and the energy efficiency will be a focal point in the design of glass façades in future. The optimal combination of transparency and energy efficiency is achieved by using point fitted insulation glass units. Their application in glass façades becomes therefore indispensable in the future.
A model to proof the structural integrity of a developed point fitted insulation glass unit with a suitable point fitting system and edge seal system is proposed. A state of the art investigation reveals the Fischer undercut anchor to be the most suitable type for the application in insulation glass. A novel design concept for point fitted insulation glass with undercut anchors is developed. The concept considers the determination of the climate loads and proposes a verification procedure for each structural element of the insulation glass unit. For this purpose, an existing climate load model for linearly supported insulation glass is analytically extended to the static system of point fitted insulation glass units with undercut anchors. For the verification of the connection undercut anchor in glass, an existing design method for point fitted single and laminated glazing is extended to point fitted insulation glass. Component tests are conducted on the Fischer anchor and its ultimate load bearing capacity in glass is determined. A calibrated numerical model of the proposed point fitted insulation glass unit with the Fischer anchor is developed for parametric studies. Large scale tests on the proposed new point fitted insulation glass unit are run with the aim to verify the numerical model, the climate load model and the extended design method and to proof the structural integrity of the entire unit. Finally a new point fitted insulation glass unit with a suitable point fitting type and a corresponding novel design concept is developed. [less ▲]Detailed reference viewed: 253 (33 UL) Proving Regulatory Compliance: Business Processes, Logic, ComplexityColombo Tosatto, Silvano Doctoral thesis (2015)The problem of proving regulatory compliance of a business process model is composed of two main elements. One of these elements is the business process model, which provides a formal compact description ... [more ▼]The problem of proving regulatory compliance of a business process model is composed of two main elements. One of these elements is the business process model, which provides a formal compact description of the available executions capable of achieving a given business objective. The other element is the regulatory framework that the business process must follow, describing the compliance requirements given by the law or by a company’s own internal regulations. The problem consists of verifying whether a given business process model is compliant with the regulatory framework, which is carried out by verifying whether the executions of the model comply with the requirements of the regulatory framework. Solutions to prove the regulatory compliance of business processes have been already proposed in the past. Some solutions disregard the computational complexity aspect of the problem, while other solutions either solve a simplified version of the problem efficiently or provide approximate solutions for the general one. However, none of these solutions have formally studied the computational complexity of the problem of proving regulatory compliance. This thesis addresses that issue, showing in addition why efficient solutions of the general problem are not possible. In particular I study the computational complexity of a problem of proving regulatory compliance whose regulatory framework is defined using conditional obligations. The approach I adopt to represent the compliance requirement is semantically similar to some of the existing solutions proposed by other researchers, such as van der Aalst and many others, who adopts linear temporal logic over finite traces, or different variants of such temporal logic, to define the compliance requirements. More precisely, the approach used in the present thesis adopts propositional logic as base logic, and defines the semantics of the regulatory framework in a similar way as Process Compliance Logic introduced by Governatori and Rotolo. The study of the computational complexity of the problem is approached by dividing it in sub-classes and then combining their analysis to obtain the result for the target problem. The division is done according to three features of the regulatory framework. These features define whether the framework is composed of a single or a set of obligations, whether the obligations are conditional and whether violations can be compensated. These features can be omitted to identify simpler sub-classes of the problem. After having identified the different sub-classes of the problem, I study the computational complexity of some of these sub-classes and combine the results obtained to identify the computational complexity of the general problem tackled in the present thesis, where each of the three features identified are used to describe the compliance requirements. The results of the computational complexity analysis show that proving the existence of an execution of a business process compliant with the regulatory framework is an NP-complete problem. Differently proving that for all of the executions of a business process model, they are either compliant or not with the regulatory framework, is a coNP-complete problem. The results show that combining the two elements composing the problem of proving regulatory compliance, the process model and the regulatory framework, which are tractable when considered individually, leads to an intractable problem. In addition to the computational complexity results, the analysis provided in the thesis has also shown that tractable sub-classes of the problem, where the computational complexity is at most polynomial with respect to the size of the input, can be obtained by trivialising the expressivity of either one of the elements composing the problem. However the expressivity of these sub-classes is limited. Thus I identify a different tractable sub-class of the problem by weakening the expressivity of both elements composing the problem, but where each element is not trivialised as for the other sub-classes. Whether the sub-class identified can be considered expressive is arguable, however it represents a first step towards identifying a sub-class of the problem being both tractable and expressive, taking into account the limitation of employing propositional logic as base logic. [less ▲]Detailed reference viewed: 149 (11 UL) Parentalité en situation vulnérable: trajectoires de résilience familiale?Dujardin, Céline Doctoral thesis (2015)The present doctoral thesis focuses on the family and specifically parents in the domain of youth protection. This area covers the support for children in vulnerable situations which may have a negative ... [more ▼]The present doctoral thesis focuses on the family and specifically parents in the domain of youth protection. This area covers the support for children in vulnerable situations which may have a negative impact on the child’s development. In contrast, the concept of resilience offers a perspective for a family trajectory which compensates for the danger to the child’s development and family functioning. In line with the goals of this study, first the theoretical framework is presented and definitions are provided for the concepts of parenting, vulnerability, resilience including the trajectory which brings the different concepts together. The aim of this project is to provide a frame of reference of reflection, based on four research question, concerning possible responses to the challenges faced by social services and families, while taking into account the specificities of the Luxembourgish context. The first research question addresses the different actors in area of youth protection and traces the policies which have evolved in dealing with families in difficult situations. The specific Luxembourg context is taken into consideration, by carrying out a discourse analysis in the area of youth protection. This analysis highlights the top-down approach by the actors in the field and points out social intervention policies aimed at improving social functioning. The second research question aims to identify factors contributing to resilience in parents facing a vulnerable situation. An exhaustive literature review was conducted, covering articles published in English, French and German. A qualitative meta-synthesis was carried out, resulting in a definition of the concept of family resilience and an identification of parental variables influencing the process of family resilience. The last two research questions concern families at risk and who therefore fall under the youth protection scheme. The study is based on the documentation by the enquêtes sociales (social surveys) conducted by the Service Central d’Assistance Sociale (SCAS) for 2006, 2009 and 2012. The analysis of this documentation reflects the evolution of the social work. Using quantitative methods, descriptive as well as exploratory analysis regarding family characteristics, risk factors and indicators, contributing to resilience could be identified. The thesis closes by proposing a summary conclusion which brings together the various findings from the different family histories within the system of youth protection and their potential in terms of family resilience. The discussion centers on the method of secondary analysis and the specificities of the Grand Duchy of Luxembourg. Finally, we highlight the additional knowledge gained through the project and point out several new perspectives for social policy development in the areas concerned. [less ▲]Detailed reference viewed: 414 (51 UL) Cheating-Tolerance of Parallel and Distributed Evolutionary Algorithms in Desktop Grids and Volunteer Computing SystemsMuszynski, Jakub Doctoral thesis (2015)This thesis analyses the fault-tolerant nature of Evolutionary Algorithms (EAs) executed in a distributed environment which is subjected to malicious acts. Such actions are a common problem in Desktop ... [more ▼]This thesis analyses the fault-tolerant nature of Evolutionary Algorithms (EAs) executed in a distributed environment which is subjected to malicious acts. Such actions are a common problem in Desktop Grids and Volunteer Computing Systems (DGVCS’s) utilising idle resources shared by volunteers. Due to the vast computational and storage capabilities provided at a low cost, many large-scale research projects are carried out using such set-ups. However, this advantage is obtained at the expense of a challenging, error prone, heteroge neous and volatile environment of execution. In the volunteer-based systems, such as BOINC, the incentives offered to the contributors attract also malicious users, commonly called cheaters. A cheater typically seeks to obtain the rewards with little or no contribution at all. Additionally, this group may also include "crackers" or "black hat hackers" - users motivated by nothing more than a pure satisfaction from violating computer security. In this study we use and formalise cheating faults - a model for the behaviours described above, which are a subtype of byzantine (arbitrary) faults. They are mainly characterised by the alteration of outputs produced by some or all tasks forming a distributed execution. The approach differs from the arbitrary faults in its implementation, as usually they are introduced intentionally and from within the boundaries of a system. The innate fault resilience of EAs has been previously observed in the literature. However, this PhD manuscript offers the first, formal analysis of the impact of cheating faults in this area of optimisation techniques. In particular, the following contributions are proposed: - An in-depth formal analysis of the cheating-tolerance of parallel Evolutionary Algorithms (EAs), including proofs of convergence or non-convergence towards valid solutions in the presence of malicious acts. A step-wise approach is used, focusing firstly on the most simple variant of an EA that is still of theoretical and practical interest, i.e. a (1 + 1) EA. Then the results are extended to regular (population-based) EAs. The analysis shows that the selection mechanism is crucial to achieve convergence of EAs executed in malicious environments. - The extension of the study to cheating-resilience of spatially-structured Evolutionary Algorithms (EAs) and gossip protocols. More precisely, we analyse Evolvable Agent Model (EvAg) relying on Newscast protocol to define neighbourhoods in the evolution and the communication layers. There, we provide the necessary conditions for convergence of the algorithm in a hostile environment and we show that the evolutionary process may be affected only by tampering with the connectivity between the computing resources. After that, we design an effective connectivity-splitting attack which is able to defeat the protocol using very few naive cheaters. Finally, we provide a set of countermeasures which ultimately lead to a more robust solution. These results have been published in several international, peer-reviewed venues and well recognized international journals. By the variety of problems addressed by EAs, this study will hopefully promote their usage in the future developments around distributed computing platforms such as Desktop Grids and Volunteer Computing Systems or Cloud systems where the resources cannot be fully trusted. [less ▲]Detailed reference viewed: 119 (16 UL) Essays on Dynamic Economic AnalysisTabakovic, Amer Doctoral thesis (2015)Detailed reference viewed: 230 (42 UL) An empirical analysis of the luxembourg mutual fund market placeIrek, Fabian Doctoral thesis (2015)Detailed reference viewed: 140 (19 UL) Novel Methods for Learning and Adaptation in Chemical Reaction NetworksBanda, Peter Doctoral thesis (2015)State-of-the-art biochemical systems for medical applications and chemical computing are application-specific and cannot be re-programmed or trained once fabricated. The implementation of adaptive ... [more ▼]State-of-the-art biochemical systems for medical applications and chemical computing are application-specific and cannot be re-programmed or trained once fabricated. The implementation of adaptive biochemical systems that would offer flexibility through programmability and autonomous adaptation faces major challenges because of the large number of required chemical species as well as the timing-sensitive feedback loops required for learning. Currently, biochemistry lacks a systems vision on how the user-level programming interface and abstraction with a subsequent translation to chemistry should look like. By developing adaptation in chemistry, we could replace multiple hard-wired systems with a single programmable template that can be (re)trained to match a desired input-output profile benefiting smart drug delivery, pattern recognition, and chemical computing. I aimed to address these challenges by proposing several approaches to learning and adaptation in Chemical Reaction Networks (CRNs), a type of simulated chemistry, where species are unstructured, i.e., they are identified by symbols rather than molecular structure, and their dynamics or concentration evolution are driven by reactions and reaction rates that follow mass-action and Michaelis-Menten kinetics. Several CRN and experimental DNA-based models of neural networks exist. However, these models successfully implement only the forward-pass, i.e., the input-weight integration part of a perceptron model. Learning is delegated to a non-chemical system that computes the weights before converting them to molecular concentrations. Autonomous learning, i.e., learning implemented fully inside chemistry has been absent from both theoretical and experimental research. The research in this thesis offers the first constructive evidence that learning in CRNs is, in fact, possible. I have introduced the original concept of a chemical binary perceptron that can learn all 14 linearly-separable logic functions and is robust to the perturbation of rate constants. That shows learning is universal and substrate-free. To simplify the model I later proposed and applied the asymmetric" chemical arithmetic providing a compact solution for representing negative numbers in chemistry. To tackle more difficult tasks and to serve more complicated biochemical applications, I introduced several key modular building blocks, each addressing certain aspects of chemical information processing and learning. These parts organically combined into gradually more complex systems. First, instead of simple static Boolean functions, I tackled analog time-series learning and signal processing by modeling an analog chemical perceptron. To store past input concentrations as a sliding window I implemented a chemical delay line, which feeds the values to the underlying chemical perceptron. That allows the system to learn, e.g., the linear moving-average and to some degree predict a highly nonlinear NARMA benchmark series. Another important contribution to the area of chemical learning, which I have helped to shape, is the composability of perceptrons into larger multi-compartment networks. Each compartment hosts a single chemical perceptron and compartments communicate with each other through a channel-mediated exchange of molecular species. Besides the feedforward pass, I implemented the chemical error backpropagation analogous to that of feedforward neural networks. Also, after applying mass-action kinetics for the catalytic reactions, I succeeded to systematically analyze the ODEs of my models and derive the closed exact and approximative formulas for both the input-weight integration and the weight update with a learning rate annealing. I proved mathematically that the formulas of certain chemical perceptrons equal the formal linear and sigmoid neurons, essentially bridging neural networks and adaptive CRNs. For all my models the basic methodology was to first design species and reactions, and then set the rate constants either "empirically" by hand, automatically by a standard genetic algorithm (GA), or analytically if possible. I performed all simulations in my COEL framework, which is the first cloud-based chemistry modeling tool, accessible at http://coel-sim.org. I minimized the amount of required molecular species and reactions to make wet chemical implementation possible. I applied an automatized mapping technique, Soloveichik's CRN-to-DNA-strand-displacement transformation, to the chemical linear perceptron and the manual signalling delay line and obtained their full DNA-strand specified implementations. As an alternative DNA-based substrate, I mapped these two models also to deoxyribozyme-mediated cleavage reactions reducing the size of the displacement variant to a third. Both DNA-based incarnations could directly serve as blue-prints for wet biochemicals. Besides an actual synthesis of my models and conducting an experiment in a biochemical laboratory, the most promising future work is to employ so-called reservoir computing (RC), which is a novel machine learning method based on recurrent neural networks. The RC approach is relevant because for time-series prediction it is clearly superior to classical recurrent networks. It can also be implemented in various ways, such as electrical circuits, physical systems, such as a colony of Escherichia Coli, and water. RC's loose structural assumptions therefore suggest that it could be expressed in a chemical form as well. This could further enhance the expressivity and capabilities of chemically-embedded learning. My chemical learning systems may have applications in the area of medical diagnosis and smart medication, e.g., concentration signal processing and monitoring, and the detection of harmful species, such as chemicals produced by cancer cells in a host (cancer miRNAs) or the detection of a severe event, defined as a linear or nonlinear temporal concentration pattern. My approach could replace “hard-coded” solutions and would allow to specify, train, and reuse chemical systems without redesigning them. With time-series integration, biochemical computers could keep a record of changing biological systems and act as diagnostic aids and tools in preventative and highly personalized medicine. [less ▲]Detailed reference viewed: 107 (4 UL) COMPUTER-ASSISTED INTERVENTIONS TO IMPROVE SELF-REGULATION IN PATIENTS WITH SELF-REGULATORY DEFICITSCampillo Costoya, Cristina Doctoral thesis (2015)The aim of the present thesis was to examine the efficacy of computer-assisted interventions in increasing self-regulation. Recent studies indicate that self-regulation is associated with executive ... [more ▼]The aim of the present thesis was to examine the efficacy of computer-assisted interventions in increasing self-regulation. Recent studies indicate that self-regulation is associated with executive function, mood disorders and heart rate variability (HRV). In Study 1, we investigated the efficacy of the use of the visual software Tic-Tac tool in reducing anxiety-related behaviours during transition periods in three adults with autism and learning difficulties. Recently it has been suggested that anxiety-related behaviours in autism are associated with emotion regulation deficits. The results of this study revealed that all three participants showed a reduction in anxiety-related behaviours such as stereotypies and nervous utterances from baseline to intervention phase. In Study 2, we investigated the effects of heart rate variability biofeedback (HRV BF) on mood and executive function in healthy volunteers, while contrasting different formats of HRV BF presentation. One group of participants completed 7 sessions of a computer-based HRV biofeedback while another group attended 10 sessions. No significant differences were found between groups. However, only Group 2, which completed 10 training sessions, showed an improvement in depression symptoms after intervention. Significant improvements were also found in positive mood, emotion regulation and flexibility at post-intervention in Group 2. In addition, this group showed an increase in positive mood and HRV indices (SDNN, Total HRV) from pre- to post-session levels. Group 1 showed a significant decrease in negative affect and an increase in HRV parameters (SDNN, Total HRV, LF HRV) across sessions. In Study 3, we examined the effects of 12 sessions of HRV BF in 21 stroke patients. Participants were assessed using cognitive tasks and self-report two times before (extended baseline) and two times after the intervention (follow-up). While this study was not able to demonstrate that HRV BF improved long-term cognitive performance or affective state in stroke patients, short-term increases of mood after training suggest that this intervention may be useful to increase emotional well-being in stroke patients. In addition, stroke patients showed increases in HRV indices (RMSSD, SDNN, LF HRV, LF/HF ratio, total HRV) from pre- to post-training session. These findings are in line with previous studies, in which no long-term effects could be observed. In addition, in study 3, emotion dysregulation was found to be associated with mood disorders. Strong correlations were also found between mood before training and changes in HRV indices from pre- to post-training. These findings advance our knowledge on the association between mood and self- regulation. In summary, these studies suggest that healthy participants, and clinical populations (e.g. stroke patients and individuals with autism) can improve self-regulation through computer-based interventions. These methods may, therefore, be useful adjunct treatments for the improvement of self-regulation. [less ▲]Detailed reference viewed: 112 (19 UL) European Union Research and Innovation Policy: The Co-production of Policy and Expertise in the Case of Hydrogen and Fuel Cell TechnologiesGalich, Ante Doctoral thesis (2015)Detailed reference viewed: 130 (17 UL) Design and Analysis of Secure Exam ProtocolsGiustolisi, Rosario Doctoral thesis (2015)Detailed reference viewed: 58 (4 UL) Greening Local Economies: Nature Parks as Instruments for Sustainable Regional DevelopmentFeyeh, Franklin Bahfon Doctoral thesis (2015)ABSTRACT The proliferation of Nature Parks in Europe and the change in the function of these areas has brought forth questions about the meaning and extent to which Nature Parks encourage practices for ... [more ▼]ABSTRACT The proliferation of Nature Parks in Europe and the change in the function of these areas has brought forth questions about the meaning and extent to which Nature Parks encourage practices for regional sustainable development. As such, research into this subject is ongoing. Since the creation of the first Nature Park in Europe some five or six decades ago, today, the functions of many of these areas have metamorphosed; triggered by increasing knowledge about the importance of existing ecosystem services in park areas, on adjacent local inhabitants. Consequently, parks have moved from areas of pure conservation to areas that combine environmental preservation with other socioeconomic demands in regional development. When this multifunctional characteristic is fixed into various regional policies, Nature Parks are generally interpreted by policy makers as necessary tools for realizing sustainable development in local areas. For the fact that parks have assumed new functions, it is certain, there are modifications in the strategies adopted for managing these areas. As a result, this study holds that the strength of Nature Parks in mitigating resource depletion, to improve socioeconomic prosperity and participatory regional processes, in rural areas in Luxembourg, is explicitly linked to the development strategies intended for these areas. The study draws on two official Nature Parks in Luxembourg (Haute Sûre and Our), to explain contemporary strategies to simultaneously integrate activities of ecological conservation, economic development, social well-being and resource governance. Therefore, the study sticks on the concept of green economy, an integrated notion in the framework of sustainable development, as for example, promoted by United Nations Environment Programme (UNEP, 2011), to draw a line between theory and practice of Nature Park development in Luxembourg. To comprehend the role and impacts of Nature Parks in regional development, the study has been guided by a qualitative methodology. Methods were chosen based on flexibility and the strength to provide useful insights about parks’ activities. This provided responses to the main research question; to what extent are strategies contributing to the appreciation of Nature Parks by local, regional and national stakeholders, as instruments for greening local economies, for the purpose of attaining sustainable regional development in Luxembourg? The dissertation presents different dimensions in which Nature Parks in Luxembourg are trying to promote regional sustainability. It made use of chapters that describe and analyse ecological policies for improving ecosystem services. This is mainly guided by schemes for environmental education, biodiversity contracts and agricultural advice that convey modernisation into traditional agricultural practices. Undeniably, approaches affixed for the development of Nature Parks have been contributing in reshaping local economies. Not only are these strategies important in integrating economic development and ecological conservation, but also, the outcomes via innovative and diversified projects have fairly improved approaches for local production. A new rural identity is now being developed, standing tall as the main strength behind the marketing of locally branded Nature Park products. Apart from the fact that organic production is still a matter of controversy, concrete social policies are lacking while local participation in Nature Parks’ activities is a critical challenge and absolutely insufficient. Away from researching on the ecological, economic, social and governance approaches for greening Nature Parks, the study has also explained certain challenges caused mainly by, but not limited to, differences between stakeholders in conceptualising Nature Parks as tool for local/regional development. The emerging drawbacks from these limitations vis-à-vis regional projects are enough reason to rethink the extent to which Nature Parks in Luxembourg encourage sustainable regional development. The research reasons that attaining sustainable development in Nature Parks is a critical challenge. This can be most effective if predestined strategies logically integrate aspects of environmental conservation, economic prosperity and social well-being, including attractive policies of regional governance. [less ▲]Detailed reference viewed: 166 (10 UL) Du style des idées : l'aphorisme dans l'oeuvre d'André GideBertrand, STEPHANIE CATHERINE Doctoral thesis (2015)Detailed reference viewed: 46 (6 UL) Explaining laws of nature: A metaphysical investigation into the natural principles governing the universeJaag, Siegfried Doctoral thesis (2015)Detailed reference viewed: 462 (24 UL) The Role of External and Internal Stimuli in the Regulation of Eating BehaviourVan Dyck, Zoé Doctoral thesis (2015)Detailed reference viewed: 244 (53 UL) Body perception and evaluation in anorexia nervosaLutz, Annika Doctoral thesis (2015)Body image disturbance is a prominent feature in anorexia nervosa (AN) and encompasses alterations across the different dimensions of body image, that is, perception, affect, cognition, and behaviour ... [more ▼]Body image disturbance is a prominent feature in anorexia nervosa (AN) and encompasses alterations across the different dimensions of body image, that is, perception, affect, cognition, and behaviour. There is a wealth of research regarding the subjective experience of body image disturbance and evidence for underlying neuronal alterations is beginning to emerge. The present project was designed to assess basic processes underlying body image disturbance with the help of psychophysiological measurement techniques and self-other discrimination tasks. In study 1, using a self-other discrimination task with distorted body images, we were able to demonstrate interactions between perceptual factors and cognitive bias which may sustain a distorted and negative body image in healthy women. Study 2 showed a discrepancy between explicit negative ratings for body shapes and implicit neutral affect towards the same images, as assessed with an affective startle-modulation paradigm, in healthy women and women with AN. These results suggest that automatic fear responses to fat-distorted self-body pictures, as well as implicit approach motivation towards thin body images, as reported in previous studies, are not present in all patients with AN. In study 3 a differential alteration of featural and configural visual processing of body images was detected in an event-related brain potentials (EEG-ERP) paradigm. Individuals with AN showed a lack of discrimination between self-body and self-object pictures between 105 and 160 ms after stimulus onset (P1 component, featural processing) and an enhanced processing of body relative to neutral object pictures between 160 and 225 ms after stimulus onset (N1 component, configural processing). This suggests alterations in the basic visual processing of body shapes in AN, which might be related to influences of top-down attentional modulation. Study 4 showed enhanced processing of cardiac visceral signals in the central nervous system (CNS) in individuals with AN, which might either be a marker of psychopathology, in particular anxiety, or an indication of clinical improvement. In summary, the present results do not support the view of a global perceptual deficit in AN, but demonstrate the complexity of body image alterations in AN. It appears mandatory to further investigate basic processes underlying body image disturbances in AN and in healthy women to arrive at a comprehensive understanding of their nature and to provide a theoretical basis for body image interventions. The importance of using specific assessment methods, such as indicators of body-related processing in the CNS, is highlighted. [less ▲]Detailed reference viewed: 531 (55 UL) Be prepared. Motivational Interviewing as pre-treatment in chronic pain rehabilitationMertens, Vera-Christina Doctoral thesis (2015)Detailed reference viewed: 107 (3 UL)