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See detailBurden of rare variants in synaptic genes in patients with severe tinnitus: An exome based extreme phenotype study
Amanat, Sana; Gallego-Martinez, Alvaro; Sollini, Joseph et al

in EBioMedicine (2021), 66(103309),

Background: tinnitus is a heterogeneous condition associated with audio logical and/or mental disorders. Chronic, severe tinnitus is reported in 1% of the population and it shows a relevant heritability ... [more ▼]

Background: tinnitus is a heterogeneous condition associated with audio logical and/or mental disorders. Chronic, severe tinnitus is reported in 1% of the population and it shows a relevant heritability, according to twins, adoptees and familial aggregation studies. The genetic contribution to severe tinnitus is unknown since large genomic studies include individuals with self-reported tinnitus and large heterogeneity in the phenotype. The aim of this study was to identify genes for severe tinnitus in patients with extreme phenotype. Methods: for this extreme phenotype study, we used three different cohorts with European ancestry (Spanish with Meniere disease (MD), Swedish tinnitus and European generalized epilepsy). In addition, four independent control datasets were also used for comparisons. Whole-exome sequencing was performed for the MD and epilepsy cohorts and whole-genome sequencing was carried out in Swedish with tinnitus. Findings: we found an enrichment of rare missense variants in 24 synaptic genes in a Spanish cohort, the most significant being PRUNE2, AKAP9, SORBS1, ITGAX, ANK2, KIF20B and TSC2 (p < 2E−04), when they were compared with reference datasets. This burden was replicated for ANK2 gene in a Swedish cohort with 97 tinnitus individuals, and in a subset of 34 Swedish patients with severe tinnitus for ANK2, AKAP9 and TSC2 genes (p < 2E−02). However, these associations were not significant in a third cohort of 701 generalized epilepsy individuals without tinnitus. Gene ontology (GO) and gene-set enrichment analyses revealed several pathways and biological processes involved in severe tinnitus, including membrane trafficking and cytoskeletal protein binding in neurons. Interpretation: a burden of rare variants in ANK2, AKAP9 and TSC2 is associated with severe tinnitus. ANK2, encodes a cytoskeleton scaffolding protein that coordinates the assembly of several proteins, drives axonal branching and influences connectivity in neurons. [less ▲]

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See detailThe role of flexibility in the light of the COVID-19 pandemic and beyond: Contributing to a sustainable and resilient energy future in Europe
Heffron, Raphael J.; Körner, Marc-Fabian; Schoepf, Michael UL et al

in Renewable and Sustainable Energy Reviews (2021), 140

The energy sector provides fuel for much of everyday life, particularly economically and socially. Fighting against the COVID-19 pandemic, a well-functioning and resilient energy sector is vital for ... [more ▼]

The energy sector provides fuel for much of everyday life, particularly economically and socially. Fighting against the COVID-19 pandemic, a well-functioning and resilient energy sector is vital for maintaining the operation of critical infrastructures, including, most importantly, the health sector, and timely economic recovery. Notwithstanding its importance in everyday life and crises, the energy sector itself is currently in a complex and far-reaching transformation to combat climate change whilst supporting the transition to a low-carbon economy and society, mainly through the development of variable renewable energy sources (RES) such as wind and solar photovoltaics. This paper highlights the need for energy resilience as countries face the triple challenge of the COVID-19 health crisis, the consequent economic crisis, and the climate crisis. Focusing on Europe, it is advanced here that with the ability to balance fluctuating electricity generation and demand, flexibility allows the energy sector to utilise low-carbon RES reliably, ensuring a more resilient and sustainable energy future. This paper derives five urgent policy recommendations for Europe that address possible impacts of COVID-19 on the economic and societal prerequisites for flexibility in energy systems. [less ▲]

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See detailFaceless Evil in Popular Culture. Introduction
Thiltges, Sébastian UL; Kohns, Oliver UL

in Cultural Express (2021), (6),

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See detailCooperative energy management of multi-energy hub systems considering demand response programs and ice storage
Bahmani, Ramin UL; Karimi, Hamid; Jadid, Shahram

in International Journal of Electrical Power and Energy Systems (2021)

Energy hub systems integrate various energy sources and interconnect different energy carriers in order to enhance the flexibility of the system. In this paper, a cooperative framework is proposed in ... [more ▼]

Energy hub systems integrate various energy sources and interconnect different energy carriers in order to enhance the flexibility of the system. In this paper, a cooperative framework is proposed in which a network of energy hubs collaborate together and share their resources in order to reduce their costs. Each hub has several sources including CHP, boiler, renewable sources, electrical chiller, and absorption chiller. Moreover, energy storages are considered for electrical, heating, and cooling systems in order to increase the flexibility of energy hubs. Unlike the methods based on Nash-equilibrium points, which find the equilibrium point and have no guarantee for optimality of the solution, the employed cooperative method finds the optimal solution for the problem. We utilize the Shapley value to allocate the overall gain of the hub’s coalition based on the contribution and efficiency of the energy hubs. The proposed method is modeled as a mixed integer linear programming problem, and the cost of network energy hubs are decreased in the cooperative operation, which shows the efficiency of this model. The results show 18.89, 10.23, and 8.72% improvement for hub1, hub2, and hub3, respectively, by using the fair revenue mechanism. [less ▲]

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See detailThe Balance Between Security, Privacy and Data Protection in IoT Data Sharing: a Critique to Traditional "Security&Privacy" Surveys
Chiara, Pier Giorgio UL

in European Data Protection Law Review (2021), 7(1), 18-30

The paper examines the normative challenges of the Internet of Things (IoT), in particular, taking into account today’s debate on privacy, data protection, and security issues brought about by IoT. Three ... [more ▼]

The paper examines the normative challenges of the Internet of Things (IoT), in particular, taking into account today’s debate on privacy, data protection, and security issues brought about by IoT. Three different layers of complexity are under scrutiny. They regard (i) moral and political theories on the concept of ‘security’; (ii) whether and to what extent information security technologies, in the context of IoT, may affect fundamental rights, such as privacy and data protection; and, (iii) new legal challenges for individual and group privacy and data protection. The overall aim of the paper is, on the one hand, to stress basic differences between privacy and data protection and why the distinction matters vis-à-vis the flow of information and data sharing on IoT. On the other hand, the intent is to stress the different meanings security has in this context, since the word is often used interchangeably to address information security, cybersecurity, or safety issues. We should take these distinctions firm, when striking balances between privacy, data protection, and ‘security’ on IoT. [less ▲]

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See detailInspecting the Mechanism of Quantitative Easing in the Euro Area
Koijen, Ralph; Koulischer, François UL; Benoît, Nguyen et al

in Journal of Financial Economics (2021)

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See detailTowards the assessment of realistic hybrid precoding in millimeter wave MIMO systems with hardware impairments
Papazafeiropoulos, Anastasios K; Papageorgiou, Georgios K; Kolawole, Oluwatayo Y et al

in IET Communications (2021), 15(12), 1606-1619

Hybrid processing in millimeter wave (mmWave) communication has been proposed as a solution to reduce the cost and energy consumption by reducing the number of radio-frequency (RF) chains. However, the ... [more ▼]

Hybrid processing in millimeter wave (mmWave) communication has been proposed as a solution to reduce the cost and energy consumption by reducing the number of radio-frequency (RF) chains. However, the impact of the inevitable residual transceiver hardware impairments (RTHIs), including the residual additive transceiver hardware impairments (RATHIs) and the amplified thermal noise (ATN), has not been sufficiently studied in mmWave hybrid processing. In this work, the hybrid precoder and combiner are designed, which include both digital and analog processing by taking into account the RATHIs and the ATN. In particular, a thorough study is provided to shed light on the degradation of the spectral efficiency (SE) of the practical system. The outcomes show the steady degradation of the performance by the ATN across all SNR values, which becomes increasingly critical for higher values of its variance. Furthermore, it is shown that RATHIs result in degradation of the system only in the high SNR regime. Hence, their impact in mmWave system operating at low SNRs might be negligible. Moreover, an increase concerning the number of streams differentiates the impact between the transmit and receive RATHIs with the latter having a more severe effect. [less ▲]

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See detailShortcuts to Squeezed Thermal States
Dupays, Léonce UL; Chenu, Aurélia UL

in Quantum (2021)

Squeezed state in harmonic systems can be generated through a variety of techniques, including varying the oscillator frequency or using nonlinear two-photon Raman interaction. We focus on these two ... [more ▼]

Squeezed state in harmonic systems can be generated through a variety of techniques, including varying the oscillator frequency or using nonlinear two-photon Raman interaction. We focus on these two techniques to drive an initial thermal state into a final squeezed thermal state with controlled squeezing parameters—amplitude and phase—in arbitrary time. The protocols are designed through reverse engineering for both unitary and open dynamics. Control of the dissipation is achieved using stochastic processes, readily implementable via, e.g., continuous quantum measurements. Importantly, this allows controlling the state entropy and can be used for fast thermalization. The developed protocols are thus suited to generate squeezed thermal states at controlled temperature in arbitrary time. [less ▲]

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See detailOn the Secrecy Performance of NOMA-Based Integrated Satellite Multiple-Terrestrial Relay Networks With Hardware Impairments
Guo, Kefeng; An, Kang; Zhou, Feng et al

in IEEE Transactions on Vehicular Technology (2021), 70

Integrated satellite terrestrial networks and non-orthogonal multiple access (NOMA) have been confirmed to be promising and effective approaches to achieve substantial performance gains for future ... [more ▼]

Integrated satellite terrestrial networks and non-orthogonal multiple access (NOMA) have been confirmed to be promising and effective approaches to achieve substantial performance gains for future wireless paradigms. This paper studies the effect of hardware impairments (HIs) on the secrecy performance of NOMA-based integrated satellite multiple-terrestrial relay networks (ISMTRNs). Particularly, we consider two important wiretapping cases: Case I, colluding case: all eavesdroppers cooperatively overhear the information; and Case II, non-colluding case: one eavesdropper with the best wiretapping quality is chosen to overhear the main channel information. Specially, the closed-form expressions for the secrecy outage probability (SOP) of the considered NOMA-based ISMTRNs in the presence of the above two eavesdropping cases and partial relay selection scheme are obtained. To obtain further insights in high signal-to-noise ratios (SNRs) regime, the asymptotic analysis of SOP with two considered cases are also derived, which give efficient means to evaluate the benefit of NOMA scheme and the impacts of HIs on the SOP. Moreover, we obtain Monte Carlo (MC) simulations for the secrecy energy efficiency (SEE). [less ▲]

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See detailImmersive Robotic Telepresence for Remote Educational Scenarios
Botev, Jean UL; Rodríguez Lera, Francisco J.

in Sustainability (2021)

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See detailVoice for Health: The Use of Vocal Biomarkers from Research to Clinical Practice
Fagherazzi, Guy UL; Fischer, Aurelie; Ismael, Muhannad et al

in Digital Biomarkers (2021), 5(1), 78-88

Diseases can affect organs such as the heart, lungs, brain, muscles, or vocal folds, which can then alter an individual’s voice. Therefore, voice analysis using artificial intelligence opens new ... [more ▼]

Diseases can affect organs such as the heart, lungs, brain, muscles, or vocal folds, which can then alter an individual’s voice. Therefore, voice analysis using artificial intelligence opens new opportunities for healthcare. From using vocal biomarkers for diagnosis, risk prediction, and remote monitoring of various clinical outcomes and symptoms, we offer in this review an overview of the various applications of voice for health-related purposes. We discuss the potential of this rapidly evolving environment from a research, patient, and clinical perspective. We also discuss the key challenges to overcome in the near future for a substantial and efficient use of voice in healthcare. [less ▲]

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See detailChronique de droit des marchés financiers
Conac, Pierre-Henri UL

in Revue des Sociétés (2021)

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See detailÉvaluation de la mémoire de travail : un outil de différenciation entre trouble du langage et différence du langage dans des contextes multilingues ?
Wealer, Cyril UL; Engel de Abreu, Pascale UL

in ANAE: Approche Neuropsychologique des Apprentissages chez l'Enfant (2021), 33(171), 194-204

Diagnostiquer les troubles du langage chez les enfants bilingues repré- sente un défi clinique en raison des similitudes dans le profil de compé- tence linguistique entre les enfants bilingues au ... [more ▼]

Diagnostiquer les troubles du langage chez les enfants bilingues repré- sente un défi clinique en raison des similitudes dans le profil de compé- tence linguistique entre les enfants bilingues au développement typique et les enfants monolingues avec un trouble du langage. Les mesures de la mémoire de travail dépendent moins des connaissances accumulées que les tests de langage traditionnels et pourraient contribuer à différen- cier un trouble du langage d’une différence de langage liée aux expé- riences avec une langue. [less ▲]

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See detailTowards global flood mapping onboard low cost satellites with machine learning
Mateo‑Garcia, Gonzalo; Veitch‑Michaelis, Joshua; Smith, Lewis et al

in Scientific Reports (2021), 11(7249 (2021)),

Spaceborne Earth observation is a key technology for flood response, offering valuable information to decision makers on the ground. Very large constellations of small, nano satellites— ’CubeSats’ are a ... [more ▼]

Spaceborne Earth observation is a key technology for flood response, offering valuable information to decision makers on the ground. Very large constellations of small, nano satellites— ’CubeSats’ are a promising solution to reduce revisit time in disaster areas from days to hours. However, data transmission to ground receivers is limited by constraints on power and bandwidth of CubeSats. Onboard processing offers a solution to decrease the amount of data to transmit by reducing large sensor images to smaller data products. The ESA’s recent PhiSat-1 mission aims to facilitate the demonstration of this concept, providing the hardware capability to perform onboard processing by including a power-constrained machine learning accelerator and the software to run custom applications. This work demonstrates a flood segmentation algorithm that produces flood masks to be transmitted instead of the raw images, while running efficiently on the accelerator aboard the PhiSat-1. Our models are trained on WorldFloods: a newly compiled dataset of 119 globally verified flooding events from disaster response organizations, which we make available in a common format. We test the system on independent locations, demonstrating that it produces fast and accurate segmentation masks on the hardware accelerator, acting as a proof of concept for this approach. [less ▲]

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See detailRevisiting the VCCFinder approach for the identification of vulnerability-contributing commits
Riom, Timothée UL; Sawadogo, Delwende Donald Arthur UL; Allix, Kevin UL et al

in Empirical Software Engineering (2021), 26

Detecting vulnerabilities in software is a constant race between development teams and potential attackers. While many static and dynamic approaches have focused on regularly analyzing the software in its ... [more ▼]

Detecting vulnerabilities in software is a constant race between development teams and potential attackers. While many static and dynamic approaches have focused on regularly analyzing the software in its entirety, a recent research direction has focused on the analysis of changes that are applied to the code. VCCFinder is a seminal approach in the literature that builds on machine learning to automatically detect whether an incoming commit will introduce some vulnerabilities. Given the influence of VCCFinder in the literature, we undertake an investigation into its performance as a state-of-the-art system. To that end, we propose to attempt a replication study on the VCCFinder supervised learning approach. The insights of our failure to replicate the results reported in the original publication informed the design of a new approach to identify vulnerability-contributing commits based on a semi-supervised learning technique with an alternate feature set. We provide all artefacts and a clear description of this approach as a new reproducible baseline for advancing research on machine learning-based identification of vulnerability-introducing commits [less ▲]

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See detailExtensional Higher-Order Paramodulation in Leo-III
Steen, Alexander UL; Benzmüller, Christoph UL

in Journal of Automated Reasoning (2021), 65

Leo-III is an automated theorem prover for extensional type theory with Henkin semantics and choice. Reasoning with primitive equality is enabled by adapting paramodulation-based proof search to higher ... [more ▼]

Leo-III is an automated theorem prover for extensional type theory with Henkin semantics and choice. Reasoning with primitive equality is enabled by adapting paramodulation-based proof search to higher-order logic. The prover may cooperate with multiple external specialist reasoning systems such as first-order provers and SMT solvers. Leo-III is compatible with the TPTP/TSTP framework for input formats, reporting results and proofs, and standardized communication between reasoning systems, enabling e.g. proof reconstruction from within proof assistants such as Isabelle/HOL. Leo-III supports reasoning in polymorphic first-order and higher-order logic, in all normal quantified modal logics, as well as in different deontic logics. Its development had initiated the ongoing extension of the TPTP infrastructure to reasoning within non-classical logics. [less ▲]

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See detailPersistence of birth mode-dependent effects on gut microbiome composition, immune system stimulation and antimicrobial resistance during the first year of life
Busi, Susheel Bhanu UL; de Nies, Laura UL; Habier, Janine UL et al

in ISME Communications (2021)

Caesarean section delivery (CSD) disrupts mother-to-neonate transmission of specific microbial strains and functional repertoires as well as linked immune system priming. Here we investigate whether ... [more ▼]

Caesarean section delivery (CSD) disrupts mother-to-neonate transmission of specific microbial strains and functional repertoires as well as linked immune system priming. Here we investigate whether differences in microbiome composition and impacts on host physiology persist at 1 year of age. We perform high-resolution, quantitative metagenomic analyses of the gut microbiomes of infants born by vaginal delivery (VD) or by CSD, from immediately after birth through to 1 year of life. Several microbial populations show distinct enrichments in CSD-born infants at 1 year of age including strains of Bacteroides caccae, Bifidobacterium bifidum and Ruminococcus gnavus, whereas others are present at higher levels in the VD group including Faecalibacterium prausnitizii, Bifidobacterium breve and Bifidobacterium kashiwanohense. The stimulation of healthy donor-derived primary human immune cells with LPS isolated from neonatal stool samples results in higher levels of tumour necrosis factor alpha (TNF-α) in the case of CSD extracts over time, compared to extracts from VD infants for which no such changes were observed during the first year of life. Functional analyses of the VD metagenomes at 1 year of age demonstrate a significant increase in the biosynthesis of the natural antibiotics, carbapenem and phenazine. Concurrently, we find antimicrobial resistance (AMR) genes against several classes of antibiotics in both VD and CSD. The abundance of AMR genes against synthetic (including semi-synthetic) agents such as phenicol, pleuromutilin and diaminopyrimidine are increased in CSD children at day 5 after birth. In addition, we find that mobile genetic elements, including phages, encode AMR genes such as glycopeptide, diaminopyrimidine and multidrug resistance genes. Our results demonstrate persistent effects at 1 year of life resulting from birth mode-dependent differences in earliest gut microbiome colonisation. [less ▲]

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See detailThe optional measures of deposit guarantee schemes: towards a new bank crisis management paradigm?
Bodellini, Marco UL

in European Journal of Legal Studies (2021)

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See detailReplication of a Novel Parkinson's Locus in a European Ancestry Population
Grover, Sandeep; Kumar-Sreelatha, Ashwin Ashok; Bobbili, Dheeraj R. et al

in Movement Disorders (2021)

ABSTRACT Background A recently published East Asian genome-wide association study of Parkinson;s disease (PD) reported 2 novel risk loci, SV2C and WBSCR17. Objectives The objective of this study were to ... [more ▼]

ABSTRACT Background A recently published East Asian genome-wide association study of Parkinson;s disease (PD) reported 2 novel risk loci, SV2C and WBSCR17. Objectives The objective of this study were to determine whether recently reported novel SV2C and WBSCR17 loci contribute to the risk of developing PD in European and East Asian ancestry populations. Methods We report an association analysis of recently reported variants with PD in the COURAGE-PD cohort (9673 PD patients; 8465 controls) comprising individuals of European and East Asian ancestries. In addition, publicly available summary data (41,386 PD patients; 476,428 controls) were pooled. Results Our findings confirmed the role of the SV2C variant in PD pathogenesis (rs246814, COURAGE-PD PEuropean = 6.64 × 10−4, pooled PD P = 1.15 × 10−11). The WBSCR17 rs9638616 was observed as a significant risk marker in the East Asian pooled population only (P = 1.16 × 10−8). Conclusions Our comprehensive study provides an up-to-date summary of recently detected novel loci in different PD populations and confirmed the role of SV2C locus as a novel risk factor for PD irrespective of the population or ethnic group analyzed. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society [less ▲]

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See detailAn Automated Framework for the Extraction of Semantic Legal Metadata from Legal Texts
Sleimi, Amin UL; Sannier, Nicolas UL; Sabetzadeh, Mehrdad UL et al

in Empirical Software Engineering (2021), 26(3), 43

Semantic legal metadata provides information that helps with understanding and interpreting legal provisions. Such metadata is therefore important for the systematic analysis of legal requirements ... [more ▼]

Semantic legal metadata provides information that helps with understanding and interpreting legal provisions. Such metadata is therefore important for the systematic analysis of legal requirements. However, manually enhancing a large legal corpus with semantic metadata is prohibitively expensive. Our work is motivated by two observations: (1) the existing requirements engineering (RE) literature does not provide a harmonized view on the semantic metadata types that are useful for legal requirements analysis; (2) automated support for the extraction of semantic legal metadata is scarce, and it does not exploit the full potential of artificial intelligence technologies, notably natural language processing (NLP) and machine learning (ML). Our objective is to take steps toward overcoming these limitations. To do so, we review and reconcile the semantic legal metadata types proposed in the RE literature. Subsequently, we devise an automated extraction approach for the identified metadata types using NLP and ML. We evaluate our approach through two case studies over the Luxembourgish legislation. Our results indicate a high accuracy in the generation of metadata annotations. In particular, in the two case studies, we were able to obtain precision scores of 97,2% and 82,4%, and recall scores of 94,9% and 92,4%. [less ▲]

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See detailLimites de la compétence pour ordonner des mesures d'instruction en France
Cuniberti, Gilles UL

in La Semaine juridique - Edition générale (2021)

L’arrêt opère un revirement de jurisprudence en jugeant que, lorsqu’il n’est pas compétent au fond, le juge français a une compétence limitée pour ordonner des mesures d’instructions sur le fondement de ... [more ▼]

L’arrêt opère un revirement de jurisprudence en jugeant que, lorsqu’il n’est pas compétent au fond, le juge français a une compétence limitée pour ordonner des mesures d’instructions sur le fondement de l’article 35 du Règlement (UE) n° 1215/2012 (Bruxelles Ibis), même lorsqu’elles doivent s’exécuter sur le territoire français. Concernant des mesures visant à obtenir la communication de documents en possession des parties adverses, elles doivent avoir pour objet de prémunir la partie demanderesse contre un risque de dépérissement d’éléments de preuve dont la conservation pouvait commander la solution du litige. Le juge français ne peut ordonner une mesure visant seulement à établir des faits, ou à déterminer les chances de succès d’une action au fond. [less ▲]

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See detailA cut finite element method for spatially resolved energy metabolism models in complex neuro-cell morphologies with minimal remeshing
Farina, Sofia UL; Claus, Susanne; Hale, Jack UL et al

in Advanced Modeling and Simulation in Engineering Sciences (2021), 8

A thorough understanding of brain metabolism is essential to tackle neurodegenerative diseases. Astrocytes are glial cells which play an important metabolic role by supplying neurons with energy. In ... [more ▼]

A thorough understanding of brain metabolism is essential to tackle neurodegenerative diseases. Astrocytes are glial cells which play an important metabolic role by supplying neurons with energy. In addition, astrocytes provide scaffolding and homeostatic functions to neighboring neurons and contribute to the blood–brain barrier. Recent investigations indicate that the complex morphology of astrocytes impacts upon their function and in particular the efficiency with which these cells metabolize nutrients and provide neurons with energy, but a systematic understanding is still elusive. Modelling and simulation represent an effective framework to address this challenge and to deepen our understanding of brain energy metabolism. This requires solving a set of metabolic partial differential equations on complex domains and remains a challenge. In this paper, we propose, test and verify a simple numerical method to solve a simplified model of metabolic pathways in astrocytes. The method can deal with arbitrarily complex cell morphologies and enables the rapid and simple modification of the model equations by users also without a deep knowledge in the numerical methods involved. The results obtained with the new method (CutFEM) are as accurate as the finite element method (FEM) whilst CutFEM disentangles the cell morphology from its discretisation, enabling us to deal with arbitrarily complex morphologies in two and three dimensions. [less ▲]

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See detailReturns to Educational and Occupational Attainment in Cognitive Performance for Middle-Aged South Korean Men and Women
Ford, Katherine Joy UL; Leist, Anja UL

in Gerontology and Geriatric Medicine (2021), 7

Background: Gender differences in late middle-age cognitive performance may be explained by differences in educational or occupational attainment rates, or gender-patterned returns of similar education ... [more ▼]

Background: Gender differences in late middle-age cognitive performance may be explained by differences in educational or occupational attainment rates, or gender-patterned returns of similar education and occupation to cognitive reserve. We tested these competing hypotheses in the historically highly gender unequal context of South Korea. Methods: Data came from the 2006 wave of the Korean Longitudinal Study of Aging. We included adults aged 45–65 years. Using quantile regression decompositions, we decomposed cognitive performance differences across quantiles into differences due to rates of educational and occupational attainment and differences due to divergent returns to those characteristics. Results: Gender-based cognitive performance differences across deciles were driven by differences in rates of educational and occupational attainment, while the returns to these characteristics were similar for both genders. Conclusions: Findings suggest that educational and occupational characteristics contribute to cognitive performance similarly in men and women, but discordant rates of these characteristics contribute to performance gaps. [less ▲]

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See detailMonitoring and prediction of hurricane tracks using GPS tropospheric products
Ejigu, Yohannes Getachew; Teferle, Felix Norman UL; Klos, Anna UL et al

in GPS Solutions (2021), (76),

We have reconstructed integrated water vapor (IWV) using the zenith wet delays to track the properties of hurricanes and explore their spatial and temporal distributions estimated from 922 GPS stations ... [more ▼]

We have reconstructed integrated water vapor (IWV) using the zenith wet delays to track the properties of hurricanes and explore their spatial and temporal distributions estimated from 922 GPS stations. Our results show that a surge in GPS-derived IWV occurred at least six hours prior to the landfall of two major hurricanes (Harvey and Irma) that struck the Gulf and East Coasts of the USA in 2017. We observed enhanced IWV, in particular, for the two hurricanes landfall locations. The observed variations exhibit a correlation with the precipitation value constructed from GPM/IMERG satellite mission coinciding with hurricane storm front passage. We used GPS-IWV data as inputs for spaghetti line plots for our path predictions, helping us predict the paths of Hurricanes Harvey and Irma. Hence, a directly estimable zenith wet delay sourced from GPS that has not been previously reported can serve as an additional resource for improving the monitoring of hurricane paths. [less ▲]

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See detailNon-universal Scaling of Thermoelectric Efficiency in 3D and 2D Thermoelectric Semiconductors
Octavian, Kevin; Hasdeo, Eddwi Hesky UL

in Advances in Natural Sciences: Nanoscience and Nanotechnology (2021), 12

We performed the first-principles calculation on common thermoelectric semiconductors Bi2Te3, Bi2Se3, SiGe, and PbTe in bulk three-dimension (3D) and two-dimension (2D). We found that miniaturization of ... [more ▼]

We performed the first-principles calculation on common thermoelectric semiconductors Bi2Te3, Bi2Se3, SiGe, and PbTe in bulk three-dimension (3D) and two-dimension (2D). We found that miniaturization of materials does not generally increase the thermoelectric figure of merit (ZT) according to the Hicks and Dresselhaus (HD) theory. For example, ZT values of 2D PbTe (0.32) and 2D SiGe (0.04) are smaller than their 3D counterparts (0.49 and 0.09, respectively). Meanwhile, the ZT values of 2D Bi2Te3 (0.57) and 2D Bi2Se3 (0.43) are larger than the bulks (0.54 and 0.18, respectively), which agree with HD theory. The HD theory breakdown occurs because the band gap and band flatness of the materials change upon dimensional reduction. We found that flat bands give a larger electrical conductivity (σ) and electronic thermal conductivity (κel) in 3D materials, and smaller values in 2D materials. In all cases, maximum ZT values increase proportionally with the band gap and saturate for the band gap above 10 kBT. The 2D Bi2Te3 and Bi2Se3 obtain a higher ZT due to the flat corrugated bands and narrow peaks in their DOS. Meanwhile, the 2D PbTe violates HD theory due to the flatter bands it exhibits, while 2D SiGe possesses a small gap Dirac-cone band. [less ▲]

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See detailShort-Packet Communications for MIMO NOMA Systems over Nakagami-m Fading: BLER and Minimum Blocklength Analysis
Tran, Duc Dung UL; Sharma, Shree Krishna UL; Chatzinotas, Symeon UL et al

in IEEE Transactions on Vehicular Technology (2021)

Recently, ultra-reliable and low-latency communications (URLLC) using short-packets has been proposed to fulfill the stringent requirements regarding reliability and latency of emerging applications in 5G ... [more ▼]

Recently, ultra-reliable and low-latency communications (URLLC) using short-packets has been proposed to fulfill the stringent requirements regarding reliability and latency of emerging applications in 5G and beyond networks. In addition, multiple-input multiple-output non-orthogonal multiple access (MIMO NOMA) is a potential candidate to improve the spectral efficiency, reliability, latency, and connectivity of wireless systems. In this paper, we investigate short-packet communications (SPC) in a multiuser downlink MIMO NOMA system over Nakagami-m fading, and propose two antenna-user selection methods considering two clusters of users having different priority levels. In contrast to the widely-used long data-packet assumption, the SPC analysis requires the redesign of the communication protocols and novel performance metrics. Given this context, we analyze the SPC performance of MIMO NOMA systems using the average block error rate (BLER) and minimum blocklength, instead of the conventional metrics such as ergodic capacity and outage capacity. More specifically, to characterize the system performance regarding SPC, asymptotic (in the high signal-to-noise ratio regime) and approximate closed-form expressions of the average BLER at the users are derived. Based on the asymptotic behavior of the average BLER, an analysis of the diversity order, minimum blocklength, and optimal power allocation is carried out. The achieved results show that MIMO NOMA can serve multiple users simultaneously using a smaller blocklength compared with MIMO OMA, thus demonstrating the benefits of MIMO NOMA for SPC in minimizing the transmission latency. Furthermore, our results indicate that the proposed methods not only improve the BLER performance, but also guarantee full diversity gains for the respective users. [less ▲]

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See detailIntroduction. Children, Young People and Borders: A Multidisciplinary Outlook.
Venken, Machteld UL; Kaisto, Virpi; Brambilla, Chiara

in Journal of Borderlands Studies (2021), 36(2), 149-158

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See detailModelling of mineral construction and demolition waste dynamics through a combination of geospatial and image analysis
Bogoviku, Lorenc; Waldmann, Daniele UL

in Journal of Environmental Management (2021), 282

As the construction sector is shifting towards circular economy models, the role of mineral construction materials as main waste fraction in terms of volumes is crucial. A characterization of this mineral ... [more ▼]

As the construction sector is shifting towards circular economy models, the role of mineral construction materials as main waste fraction in terms of volumes is crucial. A characterization of this mineral stock, as well as the waste derived from it is decisive in ensuring the application of the best practices of circular economy. This paper describes a methodology for assessing the mineral building stock through a combination of geospatial and image analysis. By analysing old topographic maps, buildings are grouped according to their building age into different typologies and based on these maps the construction and demolition activity is evaluated. The mineral stock is assessed and estimations of the mineral construction and demolition waste (CDW) is generated for different stochastic scenarios. This methodology is applied exemplarily on the country of Luxembourg. It was found that the total mineral construction stock for Luxembourg is 276.75 Mt and has been growing at a rate of 20.81% to 24.39% in the last 30 years. Furthermore, the study identified a mean age of the urban building stock of about 60 years and a typical maximum building lifetime of 122 years. Based on the stochastic projections the mineral CDW generated from the existing building stock is expected to be up to 226.9 Mt by 2100, while if future building scenarios are considered, it can be as high as 885.3 Mt. The annual CDW production is expected to be sufficient for a viable concrete recycling activity if regulations on the waste volume flows are made available. [less ▲]

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See detailA computer-guided design tool to increase the efficiency of cellular conversions
Del Sol Mesa, Antonio UL

in Nature Communications (2021)

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See detailAutomotive Squint-forward-looking SAR: High Resolution and Early Warning
Hu, Ruizhi UL; Mysore Rama Rao, Bhavani Shankar UL; Murtada, Ahmed Abdelnaser Elsayed UL et al

in IEEE Journal of Selected Topics in Signal Processing (2021)

Forward-looking automotive radars can sense long-distant targets to enable early warning, but the lateral resolution is limited. Synthetic aperture radar (SAR) techniques can achieve very high azimuth ... [more ▼]

Forward-looking automotive radars can sense long-distant targets to enable early warning, but the lateral resolution is limited. Synthetic aperture radar (SAR) techniques can achieve very high azimuth resolution but cannot resolve targets in the forward direction. As a trade-off, squint-forward-looking SAR (SFL-SAR) can perform 2D imaging on a distant area squint to the moving direction, providing both high resolution and early warning. In this paper, we analyzed and derived the constraints of automotive SFL-SAR to satisfy both the required resolution and braking distance. Simulations and imaging results verified the analysis. [less ▲]

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See detailStatistical mechanics of active Ornstein-Uhlenbeck particles
Martin, David; O’Byrne, Jérémy; Cates, Michael E. et al

in Physical Review. E. (2021)

We study the statistical properties of active Ornstein-Uhlenbeck particles (AOUPs). In this simplest of models, the Gaussian white noise of overdamped Brownian colloids is replaced by a Gaussian colored ... [more ▼]

We study the statistical properties of active Ornstein-Uhlenbeck particles (AOUPs). In this simplest of models, the Gaussian white noise of overdamped Brownian colloids is replaced by a Gaussian colored noise. This suffices to grant this system the hallmark properties of active matter, while still allowing for analytical progress. We study in detail the steady-state distribution of AOUPs in the small persistence time limit and for spatially varying activity. At the collective level, we show AOUPs to experience motility-induced phase separation both in the presence of pairwise forces or due to quorum-sensing interactions. We characterize both the instability mechanism leading to phase separation and the resulting phase coexistence. We probe how, in the stationary state, AOUPs depart from their thermal equilibrium limit by investigating the emergence of ratchet currents and entropy production. In the small persistence time limit, we show how fluctuation-dissipation relations are recovered. Finally, we discuss how the emerging properties of AOUPs can be characterized from the dynamics of their collective modes. [less ▲]

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See detailEnd-to-end Precoding Validation over a Live GEO Satellite Forward Link
Krivochiza, Jevgenij UL; Merlano Duncan, Juan Carlos UL; Querol, Jorge UL et al

in IEEE Access (2021)

In this paper we demonstrate end-to-end precoded multi-user multiple-input singleoutput (MU-MISO) communications over a live GEO satellite link. Precoded communications enable full frequency reuse (FFR ... [more ▼]

In this paper we demonstrate end-to-end precoded multi-user multiple-input singleoutput (MU-MISO) communications over a live GEO satellite link. Precoded communications enable full frequency reuse (FFR) schemes in satellite communications (SATCOM) to achieve broader service availability and higher spectrum efficiency than with the conventional four-color (4CR) and twocolor (2CR) reuse approaches. In this scope, we develop an over-the-air test-bed for end-to-end precoding validations.We use an actual multi-beam satellite to transmit and receive precoded signals using the DVB-S2X standard based gateway and user terminals. The developed system is capable of end-to-end real-time communications over the satellite link including channel measurements and precompensation. It is shown, that by successfully canceling inter-user interference in the actual satellite FFR link precoding brings gains in terms of enhanced SINR and increased system goodput. [less ▲]

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See detailCross-Linking Ligation and Sequencing of Hybrids (qCLASH) Reveals an Unpredicted miRNA Targetome in Melanoma Cells
Kozar, Ines UL; Philippidou, Demetra UL; Margue, Christiane UL et al

in Cancers (2021)

MicroRNAs are key post-transcriptional gene regulators often displaying aberrant expression patterns in cancer. As microRNAs are promising disease-associated biomarkers and modulators of responsiveness to ... [more ▼]

MicroRNAs are key post-transcriptional gene regulators often displaying aberrant expression patterns in cancer. As microRNAs are promising disease-associated biomarkers and modulators of responsiveness to anti-cancer therapies, a solid understanding of their targetome is crucial. Despite enormous research efforts, the success rates of available tools to reliably predict microRNAs (miRNA)-target interactions remains limited. To investigate the disease-associated miRNA targetome, we have applied modified cross-linking ligation and sequencing of hybrids (qCLASH) to BRAF-mutant melanoma cells. The resulting RNA-RNA hybrid molecules provide a comprehensive and unbiased snapshot of direct miRNA-target interactions. The regulatory effects on selected miRNA target genes in predicted vs. non-predicted binding regions was validated by miRNA mimic experiments. Most miRNA–target interactions deviate from the central dogma of miRNA targeting up to 60% interactions occur via non-canonical seed pairing with a strong contribution of the 3′ miRNA sequence, and over 50% display a clear bias towards the coding sequence of mRNAs. miRNAs targeting the coding sequence can directly reduce gene expression (miR-34a/CD68), while the majority of non-canonical miRNA interactions appear to have roles beyond target gene suppression (miR-100/AXL). Additionally, non-mRNA targets of miRNAs (lncRNAs) whose interactions mainly occur via non-canonical binding were identified in melanoma. This first application of CLASH sequencing to cancer cells identified over 8 K distinct miRNA–target interactions in melanoma cells. Our data highlight the importance non-canonical interactions, revealing further layers of complexity of post-transcriptional gene regulation in melanoma, thus expanding the pool of miRNA–target interactions, which have so far been omitted in the cancer field. [less ▲]

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See detailElectron hydrodynamics of anomalous Hall materials
Hasdeo, Eddwi Hesky UL; Ekström, Carl Johan Ingvar UL; Idrisov, Edvin UL et al

in Physical Review. B (2021), 103(12), 125106

We study two-dimensional electron systems in the hydrodynamic regime. We show that a geometrical Berry curvature modifies the effective Navier-Stokes equation for viscous electron flow in topological ... [more ▼]

We study two-dimensional electron systems in the hydrodynamic regime. We show that a geometrical Berry curvature modifies the effective Navier-Stokes equation for viscous electron flow in topological materials. For small electric fields, the Hall current becomes negligible compared to the viscous longitudinal current. In this regime, we highlight an unconventional Poiseuille flow with an asymmetric profile and a deviation of the maximum of the current from the center of the system. In a two-dimensional infinite geometry, the Berry curvature leads to current whirlpools and an asymmetry of potential profile. This phenomenon can be probed by measuring the asymmetric non-local resistance profile. [less ▲]

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See detailNanoscale Phononic Analog of the Ranque-Hilsch Vortex Tube
Medrano Sandonas, Leonardo UL; Rodríguez Méndez, Álvaro; Gutierrez, Rafael et al

in Physical Review Applied (2021), 15(034008),

Thermal management is a current global challenge that must be addressed exhaustively. We propose the design of a nanoscale phononic analog of the Ranque-Hilsch vortex tube in which heat flowing at a given ... [more ▼]

Thermal management is a current global challenge that must be addressed exhaustively. We propose the design of a nanoscale phononic analog of the Ranque-Hilsch vortex tube in which heat flowing at a given temperature is split into two different streams going to the two ends of the device, inducing a temperature asymmetry. Our nanoscale prototype consists of two carbon nanotubes (capped and open) connected by molecular chains. The results show that the structural asymmetry in the contact regions is the key factor for producing the flux asymmetry and, hence, the induced temperature-bias effect. The effect can be controlled by tuning the thermal-equilibration temperature, the number of chains, and the chain length. Deposition on a substrate adds another variable to the manipulation of the flux asymmetry but the effect vanishes at very large substrate temperatures. Our study yields insights into the thermal management in nanoscale materials, especially the crucial issue of whether the thermal asymmetry can survive phonon scattering over relatively long distances, and thus provides a starting point for the design of a nanoscale phononic analog of the Ranque-Hilsch vortex tube. [less ▲]

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See detailNonequilibrium thermodynamics of non-ideal chemical reaction networks
Avanzini, Francesco UL; Penocchio, Emanuele UL; Falasco, Gianmaria UL et al

in Journal of Chemical Physics (2021), 154

All current formulations of nonequilibrium thermodynamics of open chemical reaction networks rely on the assumption of non-interacting species. We develop a general theory that accounts for interactions ... [more ▼]

All current formulations of nonequilibrium thermodynamics of open chemical reaction networks rely on the assumption of non-interacting species. We develop a general theory that accounts for interactions between chemical species within a mean-field approach using activity coefficients. Thermodynamic consistency requires that rate equations do not obey standard mass-action kinetics but account for the interactions with concentration dependent kinetic constants. Many features of the ideal formulations are recovered. Crucially, the thermodynamic potential and the forces driving non-ideal chemical systems out of equilibrium are identified. Our theory is general and holds for any mean-field expression of the interactions leading to lower bounded free energies. [less ▲]

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See detailNeutron study of magnetic correlations in rare-earth-free Mn-Bi magnets
Malyeyev, Artem UL; Titov, Ivan; Bender, Philipp et al

in Physical Review Materials (2021), 5

We report the results of an unpolarized small-angle neutron scattering (SANS) study on Mn-Bi-based rare-earth-free permanent magnets. The magnetic SANS cross section is dominated by long-wavelength ... [more ▼]

We report the results of an unpolarized small-angle neutron scattering (SANS) study on Mn-Bi-based rare-earth-free permanent magnets. The magnetic SANS cross section is dominated by long-wavelength transversal magnetization fluctuations and has been analyzed in terms of the Guinier-Porod model and the distance distribution function. This provides the radius of gyration which, in the remanent state, ranges between about $220-240 \, \mathrm{nm}$ for the three different alloy compositions investigated. Moreover, computation of the distance distribution function in conjunction with results for the so-called $s$-parameter obtained from the Guinier-Porod model indicate that the magnetic scattering of a Mn$_{45}$Bi$_{55}$ sample has its origin in slightly shape-anisotropic structures. [less ▲]

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See detailUrban expansion re-visited
Hesse, Markus UL

in pnd - rethinking planning (2021), 2021(1), 42-54

This paper deals with urban expansion, that is, the growth of cities and inner-urban areas, both inside and outside of the dedicated planning perimeters. My aim is to give a brief overview of how this ... [more ▼]

This paper deals with urban expansion, that is, the growth of cities and inner-urban areas, both inside and outside of the dedicated planning perimeters. My aim is to give a brief overview of how this subject matter can be discussed from a contemporary perspective, with a certain focus on big projects that have evolved in recent decades and are on the rise again. Towards that end, I will situate the subject matter in historical contexts, provide some explanation as to the 1970s and more recent dynamics, and discuss how large-scale urban projects are being implemented. While big projects pursue different ambitions—such as economic, socio-demographic or ecological goals—they are set in place by a kind of managerial urbanism, often prioritise economic gains and thus challenge urban policy and planning. The paper concludes with a call to contextualise the variegated outcomes of new urban projects and to develop appropriate methods for monitoring and assessing urban life in these quarters. [less ▲]

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See detailEfficient Federated Learning Algorithm for Resource Allocation in Wireless IoT Networks
Nguyen, van Dinh UL; Sharma, Shree Krishna UL; Vu, Thang Xuan UL et al

in IEEE Internet of Things Journal (2021), 8(5), 3394-3409

Federated learning (FL) allows multiple edge computing nodes to jointly build a shared learning model without having to transfer their raw data to a centralized server, thus reducing communication ... [more ▼]

Federated learning (FL) allows multiple edge computing nodes to jointly build a shared learning model without having to transfer their raw data to a centralized server, thus reducing communication overhead. However, FL still faces a number of challenges such as non-iid distributed data and heterogeneity of user equipments (UEs). Enabling a large number of UEs to join the training process in every round raises a potential issue of the heavy global communication burden. To address these issues, we generalize the current state-of-the-art Federated Averaging (FedAvg) by adding a weight-based proximal term to the local loss function. The proposed FL algorithm runs stochastic gradient descent in parallel on a sampled subset of the total UEs with replacement during each global round. We provide a convergence upper bound characterizing the trade-off between convergence rate and global rounds, showing that a small number of active UEs per round still guarantees convergence. Next, we employ the proposed FL algorithm in wireless Internet-of-Things (IoT) networks to minimize either total energy consumption or completion time of FL, where a simple yet efficient path-following algorithm is developed for its solutions. Finally, numerical results on unbalanced datasets are provided to demonstrate the performance improvement and robustness on the convergence rate of the proposed FL algorithm over FedAvg. They also reveal that the proposed algorithm requires much less training time and energy consumption than the FL algorithm with full user participation. These observations advocate the proposed FL algorithm for a paradigm shift in bandwidth- constrained learning wireless IoT networks. [less ▲]

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See detailAn annotation database for chemicals of emerging concern in exposome research
Meijer, Jeroen; Lamoree, Marja; Hamers, Timo et al

in Environment International (2021), 152

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See detailA Temporary Space Where Development and Planning Emergencies Meet? Notes on an International Building Exhibition (IBA) in the Cross- Border Territories of France and Luxembourg
Becker, Tom UL; Hesse, Markus UL

in Planning Theory & Practice (2021), 22(1), 148-154

An International Building Exhibition (IBA) is currently being planned for the cross-border area of southern Luxembourg and north-eastern France (Alzette-Belval). This planning approach, mainly known in ... [more ▼]

An International Building Exhibition (IBA) is currently being planned for the cross-border area of southern Luxembourg and north-eastern France (Alzette-Belval). This planning approach, mainly known in the German building and planning context, was developed as a temporary activity to foster planning innovation and experimentation, in order to bring both formal and informal processes and regulations forward. Some have also argued that an IBA can be considered a temporary case of planning emergency, a means for trying the unusual in settings where business as usual has failed to address important problems properly. Organising an IBA has recently become increasingly popular in other European countries, such as Austria, the Netherlands or Switzerland. The aim of this note is to address some general questions as to the particular role that this instrument can play, and what it may promise (and not) to spatial planning. We also discuss the specific framework conditions and problems the French-Luxembourgian border region is confronted with. Our comment should contribute to clarifying what the underlying problems are actually about and, more specifically, in what ways an IBA could help dealing with them. Particularly, we suggest decision-makers and practitioners to follow a practice of ‘reflection before selection’: to address the very specificities of both the region and of an IBA before turning to ‘project’-based routines. This would avoid rendering the IBA as an empty signifier or a mere branding tool, while practice remains challenged by vested interests, complex policy terrains and powerful political economies. [less ▲]

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See detailZeichenhafte Überlegenheit. Zur Transgressivität des Stierwunders in der 'Silvesterlegende' Konrads von Würzburg
Bendheim, Amelie UL

in Beiträge zur mediävistischen Erzählforschung (2021), 9

Der Aufsatz befragt das Stierwunder in der ›Silvesterlegende‹ Konrads von Würzburg auf seine Funktion im Glaubensdisput zwischen Christen und Juden. Das Wunder, dessen Kraft sich über sein ... [more ▼]

Der Aufsatz befragt das Stierwunder in der ›Silvesterlegende‹ Konrads von Würzburg auf seine Funktion im Glaubensdisput zwischen Christen und Juden. Das Wunder, dessen Kraft sich über sein zeitrahmenüberschreitendes Potenzial begrün-det, vermag nicht nur christliche Überlegenheit in der erzählten Welt auszustellen, sondern erweist sich auch als offen für eine lebensweltliche, politische Inanspruchnahme. Die Heiligenlegende, die so in nicht unproblematischer Weise zum epochen-geschichtlichen Glaubenskonflikt Stellung zu beziehen vermag, rückt damit in engere Beziehung zu ›klassischen‹ Kreuzzugsepen, als es die Gattung qua Definition vermuten ließe. [less ▲]

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See detailZeitRahmenÜberschreitungen im vormodernen Erzählen. Themenheft der Beiträge zur mediävistischen Erzählforschung
Bendheim, Amelie UL; Hammer, Martin Sebastian

in Beiträge zur mediävistischen Erzählforschung (2021)

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See detailZur fairen Bewertung von Lernprodukten
Krämer, Charlotte

in Programme for Innovative Teaching and Testing (PITT): #digitallife (2021)

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See detailIntact pain modulation through manipulation of controllability and expectations in aging
González-Roldán, Ana María; Terrasa, Juan Lorenzo; Prats-Sedano, Maria Angeles et al

in European Journal of Pain (2021)

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See detailInterdependenzen von Zeitlichkeit, Rahmung und Transgressivität im vormodernen Erzählen. Eine Einleitung
Bendheim, Amelie UL; Hammer, Martin Sebastian

in Beiträge zur mediävistischen Erzählforschung (2021), (9), 1-12

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See detailLe droit à la sauce piquante n°22 - Mars 2021
Hiez, David UL; Laurent, Rémi

in Le droit à la sauce piquante (2021), 22

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See detailWho aspires to higher education? Axes of inequality, values of education and higher education aspirations in secondary schools in Luxembourg and the Swiss Canton of Bern
Hadjar, Andreas UL; Scharf, Jan; Hascher, Tina

in European Journal of Education (2021), 56(1), 9-26

This article reports a study that investigated secondary school students’ higher education aspirations (towards university studies, ISCED 6 and above) and how these differ between student groups as well ... [more ▼]

This article reports a study that investigated secondary school students’ higher education aspirations (towards university studies, ISCED 6 and above) and how these differ between student groups as well as how these are impacted by values of education. Panel data of more than 300 secondary school students in two countries, Luxembourg and Switzerland (the Swiss Canton of Bern) was analysed. Schools are structured differently in the education systems of Luxembourg and the Swiss Canton of Bern. The results of our analysis show that students in the Luxembourgish sample more often aspire to higher education than in the Swiss sample. Disparities in higher education aspirations were also more pronounced in the Luxembourgish sample, boys and students from families of low socio-economic status (SES) were less likely to aspire to higher education. While the effects of values of education are generally scarce, stimulation in terms of anticipated enjoyment and interest derived from participation in higher education seems to have a positive effect on higher education aspirations. [less ▲]

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See detailUn vidimus mal interprété de Pierre de Vianden, prévôt de Saint-Martin de Liège, et de Conon, seigneur de Reuland (ca. 1264-ca. 1275
Salemme, Timothy UL

in Hemecht: Zeitschrift für Luxemburger Geschichte (2021), 72(1), 76-85

The work of editing medieval documents is full of pitfalls. Among the greatest difficulties is undoubtedly that of providing a critical edition of the copy of a document contained in a cartulary. What is ... [more ▼]

The work of editing medieval documents is full of pitfalls. Among the greatest difficulties is undoubtedly that of providing a critical edition of the copy of a document contained in a cartulary. What is the level of reliability of this copy with respect to its archetype? What is the role of the editor of the cartulary as mediator between the archetype and the copy? What should be done in the presence of an abbreviated copy of a lost archetype? In this paper, we offer a case study illustrating these issues, by focussing on a vidimus issued by Pierre de Vianden and Conon de Reuland at the end of the 1260s-early 1270s reporting an agreement between Count Philippe I of Vianden and Henri V of Luxembourg. Improperly dated and misinterpreted by researchers in the course of the 20th century, this document is the object of a new analysis which places it in a totally different historical perspective. [less ▲]

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See detailBewertungshilfe zur Unterrichtseinheit #keinfilter
Krämer, Charlotte UL; Kang, Liana; Bissen, Manuel

in Programme for Innovative Teaching and Training (PITT): #digitallife (2021)

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See detailBewertungshilfe zur Unterrichtseinheit #gemeinsamlesen
Krämer, Charlotte UL

in Programme for Innovative Teaching and Training (PITT): #digitallife (2021)

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See detailBewertungshilfe zur Unterrichtseinheit #ichhassedich
Krämer, Charlotte UL

in Programme for Innovative Teaching and Training (PITT): #digitallife (2021)

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See detailIntentions, concepts and conceptions of research supervision: a consideration of three disciplines
Kreber, Carolin; Wealer, Cyril UL

in Teaching in Higher Education (2021)

This interview-based study with thirty doctoral supervisors in the UK focused on the diverse goals and intentions behind their supervisory activities, from which we derived a six-dimensional model of ... [more ▼]

This interview-based study with thirty doctoral supervisors in the UK focused on the diverse goals and intentions behind their supervisory activities, from which we derived a six-dimensional model of concepts of supervision. We explored how strongly each of these concepts featured in supervisors’ intentions and whether this varied by discipline. Most of the intentions underlying the activities supervisors employed pertained to the concepts ‘Enculturation’ and ‘Functional’; far fewer pertained to the concepts ‘Emancipation’, ‘Critical Thinking’, ‘Care’ and ‘Preparation for Work and Life’. When supervisors were asked to identify the intentions behind their supervision practice more generally, not in direct reference to their activities, the functional perspective was less prominent. Some differences were observed between as well as within disciplines. The study confirms and extends previous research on concepts of graduate supervision and illustrates how supervisors’ personal views, their ‘conceptions’, of supervision can be described in relation to the six concepts. [less ▲]

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See detailZur fairen Bewertung von Lernprodukten
Krämer, Charlotte UL

in Programme for Innovative Teaching and Training (PITT): #digitallife (2021)

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See detailInstitutional Investors and Infrastructure Investing
Kräussl, Roman UL; Andonov, Aleksandar; M. Rauh., Joshua

in Review of Financial Studies (2021), 34(8)(3880-3934),

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See detailAccounting for Differences in Income Inequality across Countries: Tax-benefit Policy, Labour Market Structure, Returns and Demographics
Sologon, Denisa UL; van Kerm, Philippe UL; Li, Jinjing et al

in Journal of Economic Inequality (2021), 19

This paper presents a framework for studying international differences in the distribution of household income. Integrating micro-econometric and micro-simulation approaches in a decomposition analysis ... [more ▼]

This paper presents a framework for studying international differences in the distribution of household income. Integrating micro-econometric and micro-simulation approaches in a decomposition analysis, it quantifies the role of tax-benefit systems, employment and occupational structures, labour and financial market returns, and demographic composition in accounting for differences in income inequality across countries. Building upon EUROMOD (the European tax-benefit calculator) and its harmonised datasets, the model is portable and can be implemented for cross-country comparisons between any participating country. An application to the UK and Ireland—two countries that have much in common while displaying different levels of inequality—shows that differences in tax benefit rules between the two countries account for roughly half of the observed difference in disposable household income inequality. Demographic differences play negligible roles. The Irish tax-benefit system is more redistributive than UK\textquoterights due to a higher tax progressivity and higher average transfer rates. These are largely attributable to policy parameter differences, but also to differences in pre-tax, pre-transfer income distributions. [less ▲]

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See detailBewertungshilfe zur Unterrichtseinheit #bewegteballaden
Krämer, Charlotte UL

in Programme for Innovative Teaching and Training (PITT): #digitallife (2021)

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See detailDigitales Lesen im Deutschunterricht
Baumann, Isabell Eva UL

in Programme for Innovative Teaching and Training (PITT) (2021)

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See detailBewegte Balladen: Balladen durch Erklärvideos erschließen. Unterrichtsmaterialien für den Deutschunterricht
Baumann, Isabell Eva UL

in Programme for Innovative Teaching and Training (PITT) (2021)

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See detailVaria
Schafer, Valerie UL; Henriot, Carine

in Flux: Cahiers Scientifiques Internationaux Réseaux et Territoires (2021), 123

Numéro Varia de Flux coordonné par C. Henriot et V. Schafer

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See detailKernel Selection in Nonparametric Regression
Halconruy, Hélène UL; Marie, Nicolas

in Mathematical Methods of Statistics (2021)

In the regression model Y=b(X)+ε, where X has a density f, this paper deals with an oracle inequality for an estimator of bf, involving a kernel in the sense of Lerasle et al. (2016), selected via the PCO ... [more ▼]

In the regression model Y=b(X)+ε, where X has a density f, this paper deals with an oracle inequality for an estimator of bf, involving a kernel in the sense of Lerasle et al. (2016), selected via the PCO method. In addition to the bandwidth selection for kernel-based estimators already studied in Lacour, Massart and Rivoirard (2017) and Comte and Marie (2020), the dimension selection for anisotropic projection estimators of f and bf is covered. [less ▲]

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See detailEmpowering large chemical knowledge bases for exposomics: PubChemLite meets MetFrag
Schymanski, Emma UL; Kondic, Todor UL; Neumann, Steffen et al

in Journal of Cheminformatics (2021), 13(1), 19

Abstract Compound (or chemical) databases are an invaluable resource for many scientific disciplines. Exposomics researchers need to find and identify relevant chemicals that cover the entirety of ... [more ▼]

Abstract Compound (or chemical) databases are an invaluable resource for many scientific disciplines. Exposomics researchers need to find and identify relevant chemicals that cover the entirety of potential (chemical and other) exposures over entire lifetimes. This daunting task, with over 100 million chemicals in the largest chemical databases, coupled with broadly acknowledged knowledge gaps in these resources, leaves researchers faced with too much—yet not enough—information at the same time to perform comprehensive exposomics research. Furthermore, the improvements in analytical technologies and computational mass spectrometry workflows coupled with the rapid growth in databases and increasing demand for high throughput “big data” services from the research community present significant challenges for both data hosts and workflow developers. This article explores how to reduce candidate search spaces in non-target small molecule identification workflows, while increasing content usability in the context of environmental and exposomics analyses, so as to profit from the increasing size and information content of large compound databases, while increasing efficiency at the same time. In this article, these methods are explored using PubChem, the NORMAN Network Suspect List Exchange and the in silico fragmentation approach MetFrag. A subset of the PubChem database relevant for exposomics, PubChemLite, is presented as a database resource that can be (and has been) integrated into current workflows for high resolution mass spectrometry. Benchmarking datasets from earlier publications are used to show how experimental knowledge and existing datasets can be used to detect and fill gaps in compound databases to progressively improve large resources such as PubChem, and topic-specific subsets such as PubChemLite. PubChemLite is a living collection, updating as annotation content in PubChem is updated, and exported to allow direct integration into existing workflows such as MetFrag. The source code and files necessary to recreate or adjust this are jointly hosted between the research parties (see data availability statement). This effort shows that enhancing the FAIRness (Findability, Accessibility, Interoperability and Reusability) of open resources can mutually enhance several resources for whole community benefit. The authors explicitly welcome additional community input on ideas for future developments. [less ▲]

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See detailRole of cation-mediated recombination in perovskite solar cells
Singh, Ajay UL; Kaiser, Waldemar; Gagliardi, Alessio

in Solar Energy Materials and Solar Cells (2021)

The origin of the hysteresis in the current–voltage (J–V) characteristics in perovskite solar cells (PSCs) is one of the most debated topics of recent years. Hysteretic effects are connected with the slow ... [more ▼]

The origin of the hysteresis in the current–voltage (J–V) characteristics in perovskite solar cells (PSCs) is one of the most debated topics of recent years. Hysteretic effects are connected with the slow redistribution of ionic defects during the voltage sweep. Existing literature focuses on the potential screening due to accumulated ions, solely, while neglecting the possibility of charge trapping and subsequent recombination via ions. We investigate the role of cation-mediated recombination of ions using time-dependent drift–diffusion simulations in MAPbI3 PSCs. Slow-moving cations are considered as traps for the electrons. Trapped electrons can subsequently recombine non-radiatively with holes. We analyze the role of the cation-mediated trapping and its parameters (capture coefficient, cation energy, ion mobility) as well as the scan rate on the device performance. For shallow cation energies, a decrease in open-circuit voltage and slight enhancement in hysteresis is observed. Deep cation energies lead to a substantial deterioration of device performance and large hysteresis enhancement. The presented study emphasizes the importance of considering the interaction of ions with charge carriers beyond the simple electrostatic models to improve our understanding of PSCs. [less ▲]

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See detailUAV-Assisted Secure Communications in Terrestrial Cognitive Radio Networks: Joint Power Control and 3D Trajectory Optimization
Nguyen, X. Nguyen; Nguyen, van Dinh UL; Nguyen, Van Hieu et al

in IEEE Transactions on Vehicular Communications (2021), 70(4), 3298-3313

This paper considers secure communications for an underlay cognitive radio network (CRN) in the presence of an external eavesdropper (Eve). The secrecy performance of CRNs is usually limited by the ... [more ▼]

This paper considers secure communications for an underlay cognitive radio network (CRN) in the presence of an external eavesdropper (Eve). The secrecy performance of CRNs is usually limited by the primary receiver’s interference power constraint. To overcome this issue, we propose to use an unmanned aerial vehicle (UAV) as a friendly jammer to interfere Eve in decoding the confidential message from the secondary transmitter (ST). Our goal is to jointly optimize the transmit power and UAV’s trajectory in the three-dimensional (3D) space to maximize the average achievable secrecy rate of the secondary system. The formulated optimization problem is nonconvex due to the nonconvexity of the objective and nonconvexity of constraints, which is very challenging to solve. To obtain a suboptimal but efficient solution to the problem, we first transform the original problem into a more tractable form and develop an iterative algorithm for its solution by leveraging the inner approximation framework. We further extend the proposed algorithm to the case of imperfect location information of Eve, where the average worst-case secrecy rate is considered as the objective function. Extensive numerical results are provided to demonstrate the merits of the proposed algorithms over existing approaches. [less ▲]

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See detailJoint Symbol Level Precoding and Combining for MIMO-OFDM Transceiver Architectures Based on One-Bit DACs and ADCs
Domouchtsidis, Stavros UL; Tsinos, Christos UL; Chatzinotas, Symeon UL et al

in IEEE Transactions on Wireless Communications (2021), 20(7), 4601-4613

Herein, a precoding scheme is developed for orthogonal frequency division multiplexing (OFDM) transmission in multiple-input multiple-output (MIMO) systems that use one-bit digital-to-analog converters ... [more ▼]

Herein, a precoding scheme is developed for orthogonal frequency division multiplexing (OFDM) transmission in multiple-input multiple-output (MIMO) systems that use one-bit digital-to-analog converters (DACs) and analog-to-digital converters (ADCs) at the transmitter and receiver, respectively, as a means to reduce the power consumption. Two different one-bit architectures are presented. In the first, a single user MIMO system is considered where the DACs and ADCs of the transmitter and the receiver are assumed to be one-bit and in the second, a network of analog phase shifters is added at the receiver as an additional analog-only processing step with the view to mitigate some of the effects of coarse quantization. The precoding design problem is formulated and then split into two NP-hard optimization problems, which are solved by an algorithmic solution based on the Cyclic Coordinate Descent (CCD) framework. The design of the analog post-coding matrix for the second architecture is decoupled from the precoding design and is solved by an algorithm based on the alternating direction method of multipliers (ADMM). Numerical results show that the proposed precoding scheme successfully mitigates the effects of coarse quantization and the proposed systems achieve a performance close to that of systems equipped with full resolution DACs/ADCs. [less ▲]

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See detailEnergy Efficiency Maximization in RIS-Aided Cell-Free Network with Limited Backhaul
Le, Nhat Le; Nguyen, van Dinh UL; Dobre, Octavia A. et al

in IEEE Communications Letters (2021), 25(6), 1974-1978

Integrating the reconfigurable intelligent surface in a cell-free (RIS-CF) network is an effective solution to improve the capacity and coverage of future wireless systems with low cost and power ... [more ▼]

Integrating the reconfigurable intelligent surface in a cell-free (RIS-CF) network is an effective solution to improve the capacity and coverage of future wireless systems with low cost and power consumption. The reflecting coefficients of RISs can be programmed to enhance signals received at users. This letter addresses a joint design of transmit beamformers at access points and reflecting coefficients at RISs to maximize the energy efficiency (EE) of RIS-CF networks, taking into account the limited backhaul capacity constraints. Due to a very computationally challenging nonconvex problem, we develop a simple yet efficient alternating descent algorithm for its solution. Numerical results verify that the EE of RIS-CF networks is greatly improved, showing the benefit of using RISs. [less ▲]

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See detailL-plastin Ser5 phosphorylation is modulated by the PI3K/SGK pathway and promotes breast cancer cell invasiveness
Machado, Raquel A.C.; Stojevski, Dunja; de Landtsheer, Sébastien UL et al

in Cell Communication and Signaling (2021), 19(22), 1-22

Background: Metastasis is the predominant cause for cancer morbidity and mortality accounting for approxima‑ tively 90% of cancer deaths. The actin‑bundling protein L‑plastin has been proposed as a ... [more ▼]

Background: Metastasis is the predominant cause for cancer morbidity and mortality accounting for approxima‑ tively 90% of cancer deaths. The actin‑bundling protein L‑plastin has been proposed as a metastatic marker and phos‑ phorylation on its residue Ser5 is known to increase its actin‑bundling activity. We recently showed that activation of the ERK/MAPK signalling pathway leads to L‑plastin Ser5 phosphorylation and that the downstream kinases RSK1 and RSK2 are able to directly phosphorylate Ser5. Here we investigate the involvement of the PI3K pathway in L‑plastin Ser5 phosphorylation and the functional effect of this phosphorylation event in breast cancer cells. Methods: To unravel the signal transduction network upstream of L‑plastin Ser5 phosphorylation, we performed computational modelling based on immunoblot analysis data, followed by experimental validation through inhi‑ bition/overexpression studies and in vitro kinase assays. To assess the functional impact of L‑plastin expression/ Ser5 phosphorylation in breast cancer cells, we either silenced L‑plastin in cell lines initially expressing endogenous L‑plastin or neoexpressed L‑plastin wild type and phosphovariants in cell lines devoid of endogenous L‑plastin. The established cell lines were used for cell biology experiments and confocal microscopy analysis. Results: Our modelling approach revealed that, in addition to the ERK/MAPK pathway and depending on the cellular context, the PI3K pathway contributes to L‑plastin Ser5 phosphorylation through its downstream kinase SGK3. The results of the transwell invasion/migration assays showed that shRNA‑mediated knockdown of L‑plastin in BT‑20 or HCC38 cells significantly reduced cell invasion, whereas stable expression of the phosphomimetic L‑plastin Ser5Glu variant led to increased migration and invasion of BT‑549 and MDA‑MB‑231 cells. Finally, confocal image analysis combined with zymography experiments and gelatin degradation assays provided evidence that L‑plastin Ser5 phosphorylation promotes L‑plastin recruitment to invadopodia, MMP‑9 activity and concomitant extracellular matrix degradation. Conclusion: Altogether, our results demonstrate that L‑plastin Ser5 phosphorylation increases breast cancer cell invasiveness. Being a downstream molecule of both ERK/MAPK and PI3K/SGK pathways, L‑plastin is proposed here as a potential target for therapeutic approaches that are aimed at blocking dysregulated signalling outcome of both pathways and, thus, at impairing cancer cell invasion and metastasis formation. [less ▲]

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See detailStatistical and Machine Learning Techniques in Human Microbiome Studies: Contemporary Challenges and Solutions
Moreno-Indias, Isabel; Lahti, Leo; Nedyalkova, Miroslava et al

in Frontiers in Microbiology (2021), 12

The human microbiome has emerged as a central research topic in human biology and biomedicine. Current microbiome studies generate high-throughput omics data across different body sites, populations, and ... [more ▼]

The human microbiome has emerged as a central research topic in human biology and biomedicine. Current microbiome studies generate high-throughput omics data across different body sites, populations, and life stages. Many of the challenges in microbiome research are similar to other high-throughput studies, the quantitative analyses need to address the heterogeneity of data, specific statistical properties, and the remarkable variation in microbiome composition across individuals and body sites. This has led to a broad spectrum of statistical and machine learning challenges that range from study design, data processing, and standardization to analysis, modeling, cross-study comparison, prediction, data science ecosystems, and reproducible reporting. Nevertheless, although many statistics and machine learning approaches and tools have been developed, new techniques are needed to deal with emerging applications and the vast heterogeneity of microbiome data. We review and discuss emerging applications of statistical and machine learning techniques in human microbiome studies and introduce the COST Action CA18131 “ML4Microbiome” that brings together microbiome researchers and machine learning experts to address current challenges such as standardization of analysis pipelines for reproducibility of data analysis results, benchmarking, improvement, or development of existing and new tools and ontologies. [less ▲]

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See detailThermofield dynamics: Quantum chaos versus decoherence
Xu, Zhenyu; Chenu, Aurélia UL; Prosen, Tomaž et al

in Physical Review. B, Condensed Matter and Materials Physics (2021)

Quantum chaos imposes universal spectral signatures that govern the thermofield dynamics of a many-body system in isolation. The fidelity between the initial and time-evolving thermofield double states ... [more ▼]

Quantum chaos imposes universal spectral signatures that govern the thermofield dynamics of a many-body system in isolation. The fidelity between the initial and time-evolving thermofield double states exhibits as a function of time a decay, dip, ramp, and plateau. Sources of decoherence give rise to a nonunitary evolution and result in information loss. Energy dephasing gradually suppresses quantum noise fluctuations and the dip associated with spectral correlations. Decoherence further delays the appearance of the dip and shortens the span of the linear ramp associated with chaotic behavior. The interplay between signatures of quantum chaos and information loss is determined by the competition among the decoherence, dip, and plateau characteristic times, as demonstrated in the stochastic Sachdev-Ye-Kitaev model. [less ▲]

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See detailPathoFact: a pipeline for the prediction of virulence factors and antimicrobial resistance genes in metagenomic data
de Nies, Laura UL; Lopes, Sara; Busi, Susheel Bhanu UL et al

in Microbiome (2021)

Background Pathogenic microorganisms cause disease by invading, colonizing, and damaging their host. Virulence factors including bacterial toxins contribute to pathogenicity. Additionally, antimicrobial ... [more ▼]

Background Pathogenic microorganisms cause disease by invading, colonizing, and damaging their host. Virulence factors including bacterial toxins contribute to pathogenicity. Additionally, antimicrobial resistance genes allow pathogens to evade otherwise curative treatments. To understand causal relationships between microbiome compositions, functioning, and disease, it is essential to identify virulence factors and antimicrobial resistance genes in situ. At present, there is a clear lack of computational approaches to simultaneously identify these factors in metagenomic datasets. Results Here, we present PathoFact, a tool for the contextualized prediction of virulence factors, bacterial toxins, and antimicrobial resistance genes with high accuracy (0.921, 0.832 and 0.979, respectively) and specificity (0.957, 0.989 and 0.994). We evaluate the performance of PathoFact on simulated metagenomic datasets and perform a comparison to two other general workflows for the analysis of metagenomic data. PathoFact outperforms all existing workflows in predicting virulence factors and toxin genes. It performs comparably to one pipeline regarding the prediction of antimicrobial resistance while outperforming the others. We further demonstrate the performance of PathoFact on three publicly available case-control metagenomic datasets representing an actual infection as well as chronic diseases in which either pathogenic potential or bacterial toxins are hypothesized to play a role. In each case, we identify virulence factors and AMR genes which differentiated between the case and control groups, thereby revealing novel gene associations with the studied diseases. Conclusion PathoFact is an easy-to-use, modular, and reproducible pipeline for the identification of virulence factors, bacterial toxins, and antimicrobial resistance genes in metagenomic data. Additionally, our tool combines the prediction of these pathogenicity factors with the identification of mobile genetic elements. This provides further depth to the analysis by considering the genomic context of the pertinent genes. Furthermore, PathoFact’s modules for virulence factors, toxins, and antimicrobial resistance genes can be applied independently, thereby making it a flexible and versatile tool. PathoFact, its models, and databases are freely available at https://pathofact.lcsb.uni.lu. [less ▲]

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See detailDesign Optimization for Low-Complexity FPGA Implementation of Symbol-Level Multiuser Precoding
Haqiqatnejad, Alireza UL; Krivochiza, Jevgenij UL; Merlano Duncan, Juan Carlos UL et al

in IEEE Access (2021), 9

This paper proposes and validates a low-complexity FPGA design for symbol-level precoding (SLP) in multiuser multiple-input single-output (MISO) downlink communication systems. In the optimal case, the ... [more ▼]

This paper proposes and validates a low-complexity FPGA design for symbol-level precoding (SLP) in multiuser multiple-input single-output (MISO) downlink communication systems. In the optimal case, the symbol-level precoded transmit signal is obtained as the solution to an optimization problem tailored for a given set of users’ data symbols. This symbol-by-symbol design, however, imposes excessive computational complexity on the system. To alleviate this issue, we aim to reduce the per-symbol complexity of the SLP scheme by developing an approximate yet computationally-efficient closed-form solution. The proposed solution allows us to achieve a high symbol throughput in real-time implementations. To develop the FPGA design, we express the proposed solution in an algorithmic way and translate it to hardware description language (HDL). We then optimize the processing to accelerate the performance and generate the corresponding intellectual property (IP) core. We provide the synthesis report for the generated IP core, including performance and resource utilization estimates and interface descriptions. To validate our design, we simulate an uncoded transmission over a downlink multiuser channel using the LabVIEW software, where the SLP IP core is implemented as a clock-driven logic (CDL) unit. Our simulation results show that a throughput of 100 Mega symbols per second per user can be achieved via the proposed SLP design. We further use the MATLAB software to produce numerical results for the conventional zero-forcing (ZF) and the optimal SLP techniques as benchmarks for comparison. Thereby, it is shown that the proposed FPGA implementation of SLP offers an improvement of up to 50 percent in power efficiency compared to the ZF precoding. Remarkably, it enjoys the same per-symbol complexity order as that of the ZF technique. We also evaluate the loss of the real-time SLP design, introduced by the algebraic approximations and arithmetic inaccuracies, with respect to the optimal scheme. [less ▲]

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See detailGenome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture
Chia, Ruth; Sabir, Marya S.; Bandres-Ciga, Sara et al

in Nature Genetics (2021)

The genetic basis of Lewy body dementia (LBD) is not well understood. Here, we performed whole-genome sequencing in large cohorts of LBD cases and neurologically healthy controls to study the genetic ... [more ▼]

The genetic basis of Lewy body dementia (LBD) is not well understood. Here, we performed whole-genome sequencing in large cohorts of LBD cases and neurologically healthy controls to study the genetic architecture of this understudied form of dementia, and to generate a resource for the scientific community. Genome-wide association analysis identified five independent risk loci, whereas genome-wide gene-aggregation tests implicated mutations in the gene GBA. Genetic risk scores demonstrate that LBD shares risk profiles and pathways with Alzheimer’s disease and Parkinson’s disease, providing a deeper molecular understanding of the complex genetic architecture of this age-related neurodegenerative condition. [less ▲]

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See detailBenefits, Motivations, and Challenges of International Collaborative Research: A Sociology of Science Case Study
Dusdal, Jennifer UL; Powell, Justin J W UL

in Science and Public Policy (2021), 48(2), 235-245

Contemporary science is marked by expanding, diverse forms of teamwork. Collaboration across organizational and cultural boundaries extends the possibilities of discovery. International collaborative ... [more ▼]

Contemporary science is marked by expanding, diverse forms of teamwork. Collaboration across organizational and cultural boundaries extends the possibilities of discovery. International collaborative research projects can provide findings beyond what one team could achieve alone. Motivated to grow their scientific network and maintain existing relationships, researchers increasingly collaborate, despite often unrecognized costs, since such projects are challenging to manage and carry out. Rarely studied in-depth and longitudinally, researcher perspectives are crucial to better understand the dynamics of durable collaboration networks. Thus, this retrospective, longitudinal case study of a sociology of science project applies the novel method of autoethnography to examine teamwork benefits, motivations, and challenges. Key challenges found include spatial distance and differences of culture, language, and career stage. This study, spanning North America, Europe, the Middle East, and East Asia, focused on collaborators’ characteristics and evolving perceptions of team dynamics over a decade. [less ▲]

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See detailNRAS is unique among RAS proteins in requiring ICMT for trafficking to the plasma membrane
Ahearn, Ian M.; Court, Helen R.; Siddiqui, Farid et al

in Life Science Alliance (2021)

Isoprenylcysteine carboxyl methyltransferase (ICMT) is the third of three enzymes that sequentially modify the C-terminus of CaaX proteins, including RAS. Although all four RAS proteins are substrates for ... [more ▼]

Isoprenylcysteine carboxyl methyltransferase (ICMT) is the third of three enzymes that sequentially modify the C-terminus of CaaX proteins, including RAS. Although all four RAS proteins are substrates for ICMT, each traffics to membranes differently by virtue of their hypervariable regions that are differentially palmitoylated. We found that among RAS proteins, NRAS was unique in requiring ICMT for delivery to the PM, a consequence of having only a single palmitoylation site as its secondary affinity module. Although not absolutely required for palmitoylation, acylation was diminished in the absence of ICMT. Photoactivation and FRAP of GFP-NRAS revealed increase flux at the Golgi, independent of palmitoylation, in the absence of ICMT. Association of NRAS with the prenyl-protein chaperone PDE6δ also required ICMT and promoted anterograde trafficking from the Golgi. We conclude that carboxyl methylation of NRAS is required for efficient palmitoylation, PDE6δ binding, and homeostatic flux through the Golgi, processes that direct delivery to the plasma membrane. [less ▲]

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See detailEnergy-Efficient Hybrid Symbol-Level Precoding for Large-Scale mmWave Multiuser MIMO Systems
Haqiqatnejad, Alireza UL; Kayhan, Farbod UL; Ottersten, Björn UL

in IEEE Transactions on Communications (2021), 69(5), 3119-3134

We address the symbol-level precoding design problem for the downlink of a multiuser millimeter wave (mmWave) multiple-input multiple-output (MIMO) wireless system where the transmitter is equipped with a ... [more ▼]

We address the symbol-level precoding design problem for the downlink of a multiuser millimeter wave (mmWave) multiple-input multiple-output (MIMO) wireless system where the transmitter is equipped with a large-scale antenna array. The high cost and power consumption associated with the massive use of radio frequency (RF) chains prohibit fully-digital implementation of the precoder, and therefore, we consider a hybrid analog-digital architecture where a small-sized baseband precoder is followed by two successive networks of analog on-off switches and variable phase shifters according to a fully-connected structure. We jointly optimize the digital baseband precoder and the states of the switching network on a symbol-level basis, i.e., by exploiting both the channel state information (CSI) and the instantaneous data symbols, whereas the phase-shifting network is designed only based on the CSI due to practical considerations. Our approach to this joint optimization is to minimize the Euclidean distance between the optimal fully-digital and the hybrid symbol-level precoders. Remarkably, the use of a switching network allows for power-savings in the analog precoder by switching some of the phase shifters off according to the instantaneously optimized states of the switches. Our numerical results indicate that, on average, up to 50 percent of the phase shifters can be switched off. We provide an analysis of energy efficiency by adopting appropriate power dissipation models for the analog precoder, where it is shown that the energy efficiency of precoding can substantially be improved thanks to the phase shifter selection approach, compared to the fully-digital and the state-of-the-art hybrid symbol-level schemes. [less ▲]

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See detailCompte rendu de Jakob Müller, Die importierte Nation
Brüll, Christoph UL

in H-Soz-Kult: Kommunikation und Fachinformation für die Geschichtswissenschaften (2021)

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See detailPromotion of cancer cell stemness by Ras
Chippalkatti, Rohan UL; Abankwa, Daniel UL

in Biochemical Society Transactions (2021)

Cancer stem cells (CSC) may be the most relevant and elusive cancer cell population, as they have the exquisite ability to seed new tumors. It is plausible, that highly mutated cancer genes, such as KRAS ... [more ▼]

Cancer stem cells (CSC) may be the most relevant and elusive cancer cell population, as they have the exquisite ability to seed new tumors. It is plausible, that highly mutated cancer genes, such as KRAS, are functionally associated with processes contributing to the emergence of stemness traits. In this review, we will summarize the evidence for a stemness driving activity of oncogenic Ras. This activity appears to differ by Ras isoform, with the highly mutated KRAS having a particularly profound impact. Next to established stemness pathways such as Wnt and Hedgehog (Hh), the precise, cell cycle dependent orchestration of the MAPK-pathway appears to relay Ras activation in this context. We will examine how non-canonical activities of K-Ras4B (hereafter K-Ras) could be enabled by its trafficking chaperones calmodulin and PDE6D/PDEδ. Both dynamically localize to the cellular machinery that is intimately linked to cell fate decisions, such as the primary cilium and the centrosome. Thus, it can be speculated that oncogenic K-Ras disrupts fundamental polarized signaling and asymmetric apportioning processes that are necessary during cell differentiation. [less ▲]

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See detailBackscatter-Assisted Data Offloading inOFDMA-based Wireless Powered Mobile EdgeComputing for IoT Networks
Nguyen, Xuan Phu; Tran Dinh, Hieu UL; Onireti, ‪Oluwakayode et al

in IEEE Internet of Things Journal (2021)

Mobile edge computing (MEC) has emerged as a prominent technology to overcome sudden demands on computation-intensive applications of the Internet of Things (IoT) with finite processing capabilities ... [more ▼]

Mobile edge computing (MEC) has emerged as a prominent technology to overcome sudden demands on computation-intensive applications of the Internet of Things (IoT) with finite processing capabilities. Nevertheless, the limited energy resources also seriously hinders IoT devices from offloading tasks that consume high power in active RF communications. Despite the development of energy harvesting (EH) techniques, the harvested energy from surrounding environments could be inadequate for power-hungry tasks. Fortunately, Backscatter communications (Backcom) is an intriguing technology to narrow the gap between the power needed for communication and harvested power. Motivated by these considerations, this paper investigates a backscatter-assisted data offloading in OFDMA-based wireless-powered (WP) MEC for IoT systems. Specifically, we aim at maximizing the sum computation rate by jointly optimizing the transmit power at the gateway (GW), backscatter coefficient, time-splitting (TS) ratio, and binary decision-making matrices. This problem is challenging to solve due to its non-convexity. To find solutions, we first simplify the problem by determining the optimal values of transmit power of the GW and backscatter coefficient. Then, the original problem is decomposed into two sub-problems, namely, TS ratio optimization with given offloading decision matrices and offloading decision optimization with given TS ratio. Especially, a closedform expression for the TS ratio is obtained which greatly enhances the CPU execution time. Based on the solutions of the two sub-problems, an efficient algorithm, termed the fast-efficient algorithm (FEA), is proposed by leveraging the block coordinate descent method. Then, it is compared with exhaustive search (ES), bisection-based algorithm (BA), edge computing (EC), and local computing (LC) used as reference methods. As a result, the FEA is the best solution which results in a near-globally-optimal solution at a much lower complexity as compared to benchmark schemes. For instance, the CPU execution time of FEA is about 0.029 second in a 50-user network, which is tailored for ultralow latency applications of IoT networks. [less ▲]

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See detailLatent Dirichlet Allocation Models for World Trade Analysis
Kozlowski, Diego UL; Semeshenko, Viktoriya; Molinari, Andrea

in PLoS ONE (2021), 16(2), 0245393

The international trade is one of the classic areas of study in economics. Nowadays, given the availability of data, the tools used for the analysis can be complemented and enriched with new methodologies ... [more ▼]

The international trade is one of the classic areas of study in economics. Nowadays, given the availability of data, the tools used for the analysis can be complemented and enriched with new methodologies and techniques that go beyond the traditional approach. The present paper shows the application of the Latent Dirichlet Allocation Models, a well known technique from the area of Natural Language Processing, to search for latent dimensions in the product space of international trade, and their distribution across countries over time. We apply this technique to a dataset of countries' exports of goods from 1962 to 2016. The findings show the possibility to generate higher level classifications of goods based on the empirical evidence, and also allow to study the distribution of those classifications within countries. The latter show interesting insights about countries' trade specialisation. [less ▲]

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See detailCollective motion in large deviations of active particles
Keta, Yann-Edwin; Fodor, Etienne UL; van Wijland, Frédéric et al

in Physical Review. E. (2021)

We analyze collective motion that occurs during rare (large deviation) events in systems of active particles, both numerically and analytically. We discuss the associated dynamical phase transition to ... [more ▼]

We analyze collective motion that occurs during rare (large deviation) events in systems of active particles, both numerically and analytically. We discuss the associated dynamical phase transition to collective motion, which occurs when the active work is biased towards larger values, and is associated with alignment of particles’ orientations. A finite biasing field is needed to induce spontaneous symmetry breaking, even in large systems. Particle alignment is computed exactly for a system of two particles. For many-particle systems, we analyze the symmetry breaking by an optimal-control representation of the biased dynamics, and we propose a fluctuating hydrodynamic theory that captures the emergence of polar order in the biased state. [less ▲]

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See detailWärmemarktstudie für das Großherzogtum Luxemburg - Eine Analyse des Wärmemarktes im Kontext nationaler Rahmenbedingungen und energiepolitischer Zielsetzungen
Bechtel, Steffen UL; Scholzen, Frank UL

in Bauphysik (2021), 42(6),

In 2020 hat Luxemburg seinen Klimaplan für den Zeitraum 2021 bis 2030 beschlossen, welcher ehrgeizige Ziele für den Wärmesektor enthält. Die Datenlage im Wärmesektor, vor allem bei der ... [more ▼]

In 2020 hat Luxemburg seinen Klimaplan für den Zeitraum 2021 bis 2030 beschlossen, welcher ehrgeizige Ziele für den Wärmesektor enthält. Die Datenlage im Wärmesektor, vor allem bei der Schlüsseltechnologie Wärmepumpe, ist jedoch unzureichend, zum Nachteil aller beteiligten Akteure. Die Universität Luxemburg hat deshalb eine Wärmemarktstudie erstellt, die Verkaufszahlen nationaler Hersteller und Händler im Zeitraum von 2014 bis 2018 auswertet und auf diese Weise wesentliche Trends im Hinblick auf die Klimaziele aufzeigt. Die Auswertung zeigt signifikante Unterschiede zur bisherigen Datenlage bei Wärmepumpen, die sich aufgrund der Nichtinanspruchnahme der staatlichen Förderung ergeben. Insgesamt werden deutlich mehr Anlagen installiert als bisher angenommen Der Absatz fossiler Heizkessel ist konstant, wobei eine Verschiebung des Energieträgers von Öl zu Erdgas zu verzeichnen ist. Der allgemeine Trend bewegt sich in Richtung der gesteckten Ziele. Dennoch besteht signifikanter Handlungsbedarf, da zum Erreichen der nationalen Klimaziele u. a. ein jährliches Wachstum des Luxemburger Wärmepumpenmarktes von 16 % bis 2030 angenommen wurde. [less ▲]

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See detailPathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis.
Dewan, Ramita; Chia, Ruth; Ding, Jinhui et al

in Neuron (2021), 109(3), 448-460

We examined the role of repeat expansions in the pathogenesis of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) by analyzing whole-genome sequence data from 2,442 FTD/ALS patients ... [more ▼]

We examined the role of repeat expansions in the pathogenesis of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) by analyzing whole-genome sequence data from 2,442 FTD/ALS patients, 2,599 Lewy body dementia (LBD) patients, and 3,158 neurologically healthy subjects. Pathogenic expansions (range, 40-64 CAG repeats) in the huntingtin (HTT) gene were found in three (0.12%) patients diagnosed with pure FTD/ALS syndromes but were not present in the LBD or healthy cohorts. We replicated our findings in an independent collection of 3,674 FTD/ALS patients. Postmortem evaluations of two patients revealed the classical TDP-43 pathology of FTD/ALS, as well as huntingtin-positive, ubiquitin-positive aggregates in the frontal cortex. The neostriatal atrophy that pathologically defines Huntington's disease was absent in both cases. Our findings reveal an etiological relationship between HTT repeat expansions and FTD/ALS syndromes and indicate that genetic screening of FTD/ALS patients for HTT repeat expansions should be considered. [less ▲]

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See detailMapping the Metabolic Networks of Tumor Cells and Cancer-Associated Fibroblasts
Karta, Jessica UL; Bossicard, Ysaline UL; Kotzamanis, Konstantinos UL et al

in Cells (2021)

Metabolism is considered to be the core of all cellular activity. Thus, extensive studies of metabolic processes are ongoing in various fields of biology, including cancer research. Cancer cells are known ... [more ▼]

Metabolism is considered to be the core of all cellular activity. Thus, extensive studies of metabolic processes are ongoing in various fields of biology, including cancer research. Cancer cells are known to adapt their metabolism to sustain high proliferation rates and survive in unfavorable environments with low oxygen and nutrient concentrations. Hence, targeting cancer cell metabolism is a promising therapeutic strategy in cancer research. However, cancers consist not only of genetically altered tumor cells but are interwoven with endothelial cells, immune cells and fibroblasts, which together with the extracellular matrix (ECM) constitute the tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs), which are linked to poor prognosis in different cancer types, are one important component of the TME. CAFs play a significant role in reprogramming the metabolic landscape of tumor cells, but how, and in what manner, this interaction takes place remains rather unclear. This review aims to highlight the metabolic landscape of tumor cells and CAFs, including their recently identified subtypes, in different tumor types. In addition, we discuss various in vitro and in vivo metabolic techniques as well as different in silico computational tools that can be used to identify and characterize CAF–tumor cell interactions. Finally, we provide our view on how mapping the complex metabolic networks of stromal-tumor metabolism will help in finding novel metabolic targets for cancer treatment. [less ▲]

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See detailBistability in oxidative stress response determines the migration behavior of phytoplankton in turbulence
Carrara, Francesco; Sengupta, Anupam UL; Behrendt, Lars et al

in Proceedings of the National Academy of Sciences of the United States of America (2021), 118(5), 2005944118

Turbulence is an important determinant of phytoplankton physiology, often leading to cell stress and damage. Turbulence affects phytoplankton migration both by transporting cells and by triggering ... [more ▼]

Turbulence is an important determinant of phytoplankton physiology, often leading to cell stress and damage. Turbulence affects phytoplankton migration both by transporting cells and by triggering switches in migratory behavior, whereby vertically migrating cells can actively invert their direction of migration upon exposure to turbulent cues. However, a mechanistic link between single-cell physiology and vertical migration of phytoplankton in turbulence is currently missing. Here, by combining physiological and behavioral experiments with a mathematical model of stress accumulation and dissipation, we show that the mechanism responsible for the switch in the direction of migration in the marine raphidophyte Heterosigma akashiwo is the integration of reactive oxygen species (ROS) signaling generated by turbulent cues. Within timescales as short as tens of seconds, the emergent downward-migrating subpopulation exhibited a twofold increase in ROS, an indicator of stress, 15% lower photosynthetic efficiency, and 35% lower growth rate over multiple generations compared to the upward-migrating subpopulation. The origin of the behavioral split as a result of a bistable oxidative stress response is corroborated by the observation that exposure of cells to exogenous stressors (H2O2, UV-A radiation, or high irradiance), in lieu of turbulence, caused comparable ROS accumulation and an equivalent split into the two subpopulations. By providing a mechanistic link between the single-cell mechanics of swimming and physiology on the one side and the emergent population-scale migratory response and impact on fitness on the other, the ROS-mediated early warning response we discovered contributes to our understanding of phytoplankton community composition in future ocean conditions. [less ▲]

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See detailQM7-X, a comprehensive dataset of quantum-mechanical properties spanning the chemical space of small organic molecules
Hoja, Johannes UL; Medrano Sandonas, Leonardo UL; Ernst, Brian G. et al

in Scientific Data (2021), 8(43),

We introduce QM7-X, a comprehensive dataset of 42 physicochemical properties for ≈4.2 million equilibrium and non-equilibrium structures of small organic molecules with up to seven non-hydrogen (C, N, O ... [more ▼]

We introduce QM7-X, a comprehensive dataset of 42 physicochemical properties for ≈4.2 million equilibrium and non-equilibrium structures of small organic molecules with up to seven non-hydrogen (C, N, O, S, Cl) atoms. To span this fundamentally important region of chemical compound space (CCS), QM7-X includes an exhaustive sampling of (meta-)stable equilibrium structures—comprised of constitutional/structural isomers and stereoisomers, e.g., enantiomers and diastereomers (including cis-/trans- and conformational isomers)—as well as 100 non-equilibrium structural variations thereof to reach a total of ≈4.2 million molecular structures. Computed at the tightly converged quantum-mechanical PBE0+MBD level of theory, QM7-X contains global (molecular) and local (atom-in-a-molecule) properties ranging from ground state quantities (such as atomization energies and dipole moments) to response quantities (such as polarizability tensors and dispersion coefficients). By providing a systematic, extensive, and tightly-converged dataset of quantum-mechanically computed physicochemical properties, we expect that QM7-X will play a critical role in the development of next-generation machine-learning based models for exploring greater swaths of CCS and performing in silico design of molecules with targeted properties. [less ▲]

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See detailInternal and international parental migration and the living conditions of children in Ghana
Cebotari, Victor UL; Dito, Bilisuma

in Children and Youth Services Review (2021), 121(February), 105821

Relatively little is known about the effects of parental migration on the living conditions of children who stay behind. Using survey data collected in 2010 from Ghanaian school children (11–18 years; N ... [more ▼]

Relatively little is known about the effects of parental migration on the living conditions of children who stay behind. Using survey data collected in 2010 from Ghanaian school children (11–18 years; N = 2100), this study investigates variations in children’s durable goods and private utilities when parents migrate internally or internationally compared to a control group of children who live with their parents. The study also investigates whether the effects are contingent upon the marital situation of the parents. The findings show that parental migration is not associated with poorer living conditions for Ghanaian children. Rather, specific factors, such as parental divorce, internal migration and the gender of the child, influence whether children experience a decline in their living conditions when parents migrate. [less ▲]

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See detailRaumplanung und Weiterbildung in Luxemburg
Becker, Tom UL; Hesse, Markus UL

in RaumPlanung (2021), 2021(210), 60-65

Das Großherzogtum Luxemburg ist eines der kleinsten Mitgliedsländer der Europäischen Union und hat in der jüngeren Vergangenheit ein massives Wachstum von Wirtschaft und Bevölkerung erfahren. COVID-19 und ... [more ▼]

Das Großherzogtum Luxemburg ist eines der kleinsten Mitgliedsländer der Europäischen Union und hat in der jüngeren Vergangenheit ein massives Wachstum von Wirtschaft und Bevölkerung erfahren. COVID-19 und die Gegenmaßnahmen der Politik haben die hohe Außenorientierung des Landes jedoch empfindlich getroffen. Am Beispiel der Raumplanungs-Weiterbildung ‚Formation Continue Aménagement du Territoire (FCAT)‘ zeigt dieser Beitrag, wie raumplanerische Lehre und Forschung auf diese neuen Herausforderungen reagieren, sowohl inhaltlich wie auch didaktisch. [less ▲]

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See detailSecondary school principals and liminality in Polish Upper Silesia (1919-1939)
Venken, Machteld UL

in Journal of Modern European History (2021)

Establishing and implementing rules that would teach young people to become active citizens became a crucial technique for turning those spots on the map of Europe whose sovereignty had shifted after ... [more ▼]

Establishing and implementing rules that would teach young people to become active citizens became a crucial technique for turning those spots on the map of Europe whose sovereignty had shifted after World War I into lived social spaces. This article analyses how principals of borderland secondary schools negotiated transformation in Polish Upper Silesia with the help of Arnold Van Gennep’s notion that a shift in social statuses possessed a spatiality and temporality of its own. The article asks whether and how school principals were called on to offer elite training that would make Polish Upper Silesia more cohesive with the rest of Poland in terms of the social origins of pupils and the content of the history curriculum. In addition, it examines the extent to which borderland school principals accepted, refuted, or helped to shape that responsibility. The social origins of pupils are detected through a quantitative analysis of recruitment figures and the profiles of pupils’ parents. This analysis is combined with an exploration of how school principals provided a meaningful explanation of the recent past (World War I and the Silesian Uprisings). The article demonstrates that while school principals were historical actors with some room to make their own decisions when a liminal space was created, changed, and abolished, it was ultimately a priest operating in their shadows who possessed more possibilities to become a master of ceremonies leading elite education through its rites of passage. [less ▲]

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See detailNein to ‘Transfer Union’: the German brake on the construction of a European Union fiscal capacity
Howarth, David UL; Schild, Joachim

in Journal of European Integration (2021), 43(2), 207-224

This paper argues that, on the development of European Union (EU)/Eurozone fiscal capacity German governments have consistently engaged in foot-dragging. Few German state elites have ever supported ... [more ▼]

This paper argues that, on the development of European Union (EU)/Eurozone fiscal capacity German governments have consistently engaged in foot-dragging. Few German state elites have ever supported European fiscal capacity building beyond the EC budget. Following the outbreak of the Eurozone sovereign debt crisis, German governments agreed to the creation of financial support mechanisms only with reluctance. We see a case of continuity in German policy preferences driven by consistent ordoliberal and, specifically, moral hazard concerns. The important longterm change that we can observe relates to the growing importance for successive governments of avoiding audience costs driven by sceptical public opinion and the rise of a challenger party in German politics. German government support for a massive EU fiscal response to the economic crisis triggered by the COVID-19 pandemic demonstrates an exceptional policy position in favour of temporary financial mechanisms involving no fiscal transfers among member state governments. [less ▲]

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See detailLe retour du corps refoulé
Becker, Katrin UL

in Esprit (2021)

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See detailWhat´s in a diagnosis: The Effect of Externalizing and Internalizing Students´ Behaviour on Pre-service Teachers' Classroom Management and Interaction Strategies
Glock, Sabine UL; Pit-Ten Cate, Ineke UL

in British Journal of Educational Psychology (2021), 91(4), 1185-1201

Background. All over the word, classrooms are getting more and more diverse and teachers are required to effectively manage these classes even when students have special education needs (SEN). Aims. The ... [more ▼]

Background. All over the word, classrooms are getting more and more diverse and teachers are required to effectively manage these classes even when students have special education needs (SEN). Aims. The study aimed to investigate classroom management strategies and interpersonal teacher behaviour in relation to students internalizing and externalizing behaviour, whereby we varied the diagnosis of special educational needs. Sample. Two hundred and fifty-four German pre-service teachers (143 female) with a mean age of 26.04 years participated in the study. Method. Using an experimental between-subjects design, a fictitious student was described as exhibiting either internalizing or externalizing behaviour. Additionally, we varied whether the student was diagnosed as having SEN or not. The participants were asked to indicate which strategies they would apply and how they would interact with students. Results. Results showed that teacher interaction in response to both students with internalizing and externalizing behaviour approached ideal interpersonal teacher behaviour (i.e. high level of cooperativeness with certain level of dominance), whereas pre-service teachers applied all classroom management strategies to minimize effects of student behaviour on learning time. Although pre-service teachers adapted their responses based on type of behaviour, they only made allowances for internalizing behaviour while their response to externalizing behaviour did not vary much as a function of a SEN diagnosis. Conclusions. Together, these findings highlight the importance of providing preservice teachers with the pedagogical knowledge concerning effective classroom management and flexible use of strategies in response to diverse student needs in inclusive classrooms. [less ▲]

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See detailMood-induced changes in the cortical processing of food images in bulimia nervosa
Lutz, Annika UL; Dierolf, Angelika; van Dyck, Zoé UL et al

in Addictive Behaviors (2021), 113

Background Negative mood often triggers binge eating in bulimia nervosa (BN). We investigated motivational salience as a possible underlying mechanism using event-related potentials (ERPs) as indicators ... [more ▼]

Background Negative mood often triggers binge eating in bulimia nervosa (BN). We investigated motivational salience as a possible underlying mechanism using event-related potentials (ERPs) as indicators of motivated attention allocation (P300) and sustained processing (LPP). Methods We collected ERPs (P300: 350–400 ms; LPP: 600–1000 ms) from 21 women with full-syndrome or partially remitted BN and 21 healthy women (HC), matched for age and body mass index. Idiosyncratic negative and neutral situations were used to induce corresponding mood states (counterbalanced), before participants viewed images of high- and low-calorie foods and neutral objects, and provided ratings for pleasantness and desire to eat. Results P300 was larger for foods than objects; LPP was largest for high-calorie foods, followed by low-calorie foods, then objects. The BN group showed an increased desire to eat high-calorie foods under negative mood and stronger mood induction effects on ERPs than the HC group, with generally reduced P300 and a small increase in LPP for high-calorie foods. Effects were limited to circumscribed electrode positions. Exploratory analyses showed clearer effects when comparing high vs. low emotional eaters. Conclusion We argue that negative mood decreased the availability of cognitive resources (decreased P300) in BN, thereby facilitating disinhibition and food cravings (increased desire-to-eat ratings). Increased sustained processing might be linked to emotional eating tendencies rather than BN pathology per se, and reflect approach motivation, conflict, or regulatory processes. Negative mood appears to induce complex changes in food image processing, whose understanding may contribute to the development of tailored interventions in the future. [less ▲]

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