Incidence of juvenile type 1 (insulin dependent) diabetes mellitus in France

in Diabetologia (1990), 33

Oxatomide and calcium: mechanisms involved in the secretion of mast cell mediators

in Annales de Dermatologie et de Vénéréologie (1990), 117 Suppl 1

Human cutaneous mast cells and their experimental model rat peritoneal mast cells, can be stimulated by an IgE-dependent process or by peptides through the direct activation of G proteins. Both activation ... [more ▼]

Human cutaneous mast cells and their experimental model rat peritoneal mast cells, can be stimulated by an IgE-dependent process or by peptides through the direct activation of G proteins. Both activation pathways lead to the increase of cytosolic Ca2+ level. This increase in dependent of the mobilisation of intracellular calcium stores of the endoplasmic reticulum involving the stimulation of IP3-sensitive calcium channels. Mast cells are characterized by the absence of calcium channels in the plasma membrane. Oxatomide has been synthetized as an analog of cinnarizine. However oxatomide is inactive on current calcium channels. In mast cells, oxatomide inhibits the increase of cytosolic calcium elicited during mast cell activation. Consequently mast cell exocytosis is inhibited altogether with the release of newly synthetized mediators. The authors propose several putative targets for oxatomide in mast cells. The therapeutic effect of oxatomide is also related to its property to antagonize the effects of anaphylactic mediators on their selective receptors. [less ▲]

The role of homeobox genes in mammalian development

in Developmental Endocrinology (1990)

Analysis of the spatial and temporal control of Hox 1.1 in transgenic mice

in Development (1990), (108), 435-442

De 'psychological' en 'intellectualistic fallacy' voorbij. Kanttekeningen bij Sylvia Nossents "Over het ontstaan van de psyche bij mens en dier".

in Psychologie & maatschappij (1990), 53

Central extensions and semi-infinite wedge representations of Krichever-Novikov algebras for more than two points

in Letters in Mathematical Physics (1990), 20

Balans voor de toekomst. Impressies van het 12e congres van de Deutsche Gesellschaft für Erziehungswissenschaft te Bielefeld, 19-21 maart 1990.

in Pedagogisch Tijdschrift: Forum voor Opvoedkunde (1990), 15(4), 233-239

From the structure to the function of villin, an actin-binding protein of the brush border.

in BioEssays (1990), 12(9), 403-8

Villin, a calcium-regulated actin-binding protein, modulates the structure and assembly of actin filaments in vitro. It is organized into three domains, the first two of which are homologous. Villin is ... [more ▼]

Villin, a calcium-regulated actin-binding protein, modulates the structure and assembly of actin filaments in vitro. It is organized into three domains, the first two of which are homologous. Villin is mainly produced in epithelial cells that develop a brush border and which are responsible for nutrient uptake. Expression of the villin structural gene is precisely regulated during mouse embryogenesis and is restricted in adults, to certain epithelia of the gastrointestinal and urogenital tracts. The function of villin has been assessed by transfecting CV1 cells with a human cDNA encoding wild-type villin or mutant villin. Synthesis of large amounts of villin in cells which do not normally produce this protein induces the growth of microvilli on the cell surface and the redistribution of F-actin, concomitant with the disappearance of stress fibers. The complete villin sequence is required for the morphogenic effect. These results suggest that villin plays a key role in the morphogenesis of microvilli. [less ▲]

[Hypertensive heart disease. Pathophysiological foundation, diagnosis and therapy].

in Deutsche medizinische Wochenschrift (1946) (1990), 115(39), 1480-6

La filiation

in Feuille de liaison de la Conférence Saint-Yves n° 75 (1990)

Psychological impact of continuous subcutaneous insulin infusion pump therapy in non-selected newly diagnosed insulin dependent (type 1) diabetic children: Evaluation after two years of therapy [IMPACT PSYCHOLOGIQUE D'UN TRAITEMENT PAR PERFUSION SOUS-CUTANEE CONTINUE D'INSULINE DES LE DIAGNOSTIC CHEZ LES ENFANTS DIABETIQUES NON SELECTIONNES: EVALUATIONS APRES DEUX AND DE TRAITEMENT]

in Diabete et Metabolisme (1990), 16(4), 273-277

Thirty type 1 (insulin dependent) diabetic children were treated from diagnosis onwards in a random order (using a table of random permutations) with either continous subcutaneous insulin infusion pump ... [more ▼]

Thirty type 1 (insulin dependent) diabetic children were treated from diagnosis onwards in a random order (using a table of random permutations) with either continous subcutaneous insulin infusion pump therapy (CSII), or with conventional injection therapy (CT). After two years of therapy psychosocial measurements were obtained of fifteen CSII children (8 boys, 7 girls; mean age: 12+/-4 years) and thirteen CT children (6 boys, 7 girls; mean age: 10+/-4 years) and their parents. Two families of the CT group refused to participate. The examination consisted of six tests (for the children: junior dutch personality test, WISC-R intelligence test, family relation test, diabetes questionnaire; for the parents: family interaction scale and assessment of acceptance scale). Parents (and pediatricians) rated CSII children higher on compliance and better on metabolic control. Acceptance of diabetes, physical and psychological condition was rated equally by parents and doctors. Except for the diabetes questionnaire, the children of the two groups scored not significantly different. The CSII group expressed significantly less physical complaints and physical restrictions. CSII children showed a tendency to score higher on recalcitrance compared with CT children. How adequate this coping of CSII children may be, is discussed. [less ▲]

Isolated myocardial cells: a new tool for the investigation of hypertensive heart disease.

in Journal of Hypertension. Supplement) (1990), 8(4), 99-102

Cardiac hypertrophy is characterized by marked abnormalities in the contraction/relaxation pattern of the heart. For example, delayed relaxation is a prominent feature, impairing ventricular filling and ... [more ▼]

Cardiac hypertrophy is characterized by marked abnormalities in the contraction/relaxation pattern of the heart. For example, delayed relaxation is a prominent feature, impairing ventricular filling and coronary flow. In intact heart preparations the relative contribution of fibrosis and of the myocardial cell itself to these abnormalities cannot be correctly assessed. Biochemical studies on the mechanisms of impaired contraction and relaxation and hypertensive heart failure are hampered by the fact that 75% of all heart cells are non-myocytes. We therefore established the model of the isolated calcium-tolerant, adult rat cardiomyocyte as a new approach to the investigation of these problems. Contractility was measured using a videomicroscope system with high time resolution (1 ms). Angiotensin II induced a marked relaxation delay in the cardiomyocyte from normotensive rats and showed a moderate positive inotropic effect, whereas isoproterenol had a strong positive inotropic effect but accelerated relaxation. Therefore, angiotensin II is capable of inducing a relaxation delay even in the absence of coronary ischaemia or hypertension. These first results show that the isolated cardiomyocyte model may be a useful approach to investigating the mechanisms of hypertensive heart disease. [less ▲]

Development(s) in mouse genetics.

in Biochemistry & Cell Biology (1990), 68(2), 404-7

Neuropeptides and inflammation: presumed mechanisms in neurogenic inflammation

in Pathologie et Biologie (1990), 38(1), 53-6

Neuropeptides, among which substance P, VIP (Vasoactive intestinal peptide), somatostatin, neurotensin, dynorphin and enkephalins, are able to modulate inflammatory processes. Increasing interest is now ... [more ▼]

Neuropeptides, among which substance P, VIP (Vasoactive intestinal peptide), somatostatin, neurotensin, dynorphin and enkephalins, are able to modulate inflammatory processes. Increasing interest is now devoted to these peptides in different inflammatory diseases, concerning skin, lung and joins. The effect of substance P can be dependent on its C-terminal moiety implicating by this way an interaction with specific neurokinin receptors or can be dependent on its N-terminal moiety which does not involve a specific membrane receptor. Such diversity of the action mechanisms of peptides should influence the evolution of the anti-inflammatory therapeutic. [less ▲]

Cardiac baroreflex sensitivity assessment using spontaneous sequence analysis of continuous non-invasive blood pressure recordings in man.

in Journal of Physiology (1990), 422

The Fourth International Workshop on the Standardisation of Insulin Autoantibody Measurement

in Diabetologia (1990), 33(10), 638-639

[No abstract available]

Cardiac baroreflex function during postural change using non-invasive spontaneous sequence analysis in young men.

in Cardiovascular Research (1990), 24

STUDY OBJECTIVE: The aim was to assess the value of baroreflex sensitivity estimates calculated from analyses of spontaneous systolic blood pressure and pulse interval sequences derived from continuous ... [more ▼]

STUDY OBJECTIVE: The aim was to assess the value of baroreflex sensitivity estimates calculated from analyses of spontaneous systolic blood pressure and pulse interval sequences derived from continuous non-invasive finger blood pressure recordings during sitting and active standing. DESIGN: Continuous recordings of digital systolic blood pressure and pulse interval were obtained non-invasively using a Finapres FD5 during 5 min trials of sitting and standing. SUBJECTS: Subjects were healthy males aged 19-28, divided into those with "high" normal (n = 18) and "low" normal (n = 17) blood pressure. MEASUREMENTS AND MAIN RESULTS: Recordings were scanned for spontaneous sequences of three or more cardiac cycles over which systolic blood pressure increased progressively in conjunction with prolonged pulse interval, or decreased while pulse interval became shorter. Regressions between blood pressure and pulse interval (r greater than 0.80) provided estimates of cardiac baroreceptor reflex control. Computations were carried out with concurrent blood pressure and pulse interval measurements, and with a delay or lag of one and two cycles between the two variables. Pulse interval was reduced from an average 870.3 ms sitting to 571.3 ms on standing. Mean baroreflex sensitivity while sitting averaged 17.5 ms.mm Hg-1 at a delay of one cycle, failing to 7.65 ms.mm Hg-1 with standing. The decrease in sensitivity was correlated with the change in pulse interval between trials. The number of sequences was also significantly reduced with standing as opposed to sitting. Three cycle sequences were most frequent, with a lesser number of sequences involving 4, 5, and 6 or more cycles. No significant differences between "high" and "low" normal blood pressure groups were observed. CONCLUSIONS: The analysis of spontaneous sequences from non-invasive recordings may provide useful information concerning cardiac baroreflex control in different postural and behavioural states. A lag of one cycle between systolic blood pressure and pulse interval may provide the most representative estimates of baroreflex sensitivity. [less ▲]

Variations of cervical vertebrae after expression of a Hox-1.1 transgene in mice.

in Cell (1990), 61(2), 301-8

To understand the function of murine homeobox genes, a genetic analysis is mandatory. We generated gain-of-function mutants by introducing genomic sequences of the Hox-1.1 gene under the control of a ... [more ▼]

To understand the function of murine homeobox genes, a genetic analysis is mandatory. We generated gain-of-function mutants by introducing genomic sequences of the Hox-1.1 gene under the control of a chicken beta-actin promoter into mice. Our previous data had shown that these transgenic mice are nonviable after birth and are born with craniofacial abnormalities. In a subsequent detailed analysis of severely affected animals, malformations of the basioccipital bone, the atlas, and the axis were observed. Manifestation of an additional vertebra, a proatlas, occurred at the craniocervical transition. The dominant interference of the Hox-1.1 transgene with developmental programs seems to occur around day 9 of gestation, the time of neural crest migration and somite differentiation. We discuss the resulting phenotype with respect to a developmental control function of Hox-1.1. [less ▲]

«Palomar, palombaro perplesso»

in Gruppo di Contatto "Italianistica" (1989)

GaInAs Camel Transistors Grown by MOCVD

in Electronics Letters (1989), 25(1989), 1462-1463

Craniofacial abnormalities induced by ectopic expression of the homeobox gene Hox-1.1 in transgenic mice.

in Cell (1989), 58(2), 337-47

Hox-1.1 is a murine homeobox-containing gene expressed in a time- and cell-specific manner during embryogenesis. We have generated transgenic mice that ectopically express Hox-1.1 from the chicken beta ... [more ▼]

Hox-1.1 is a murine homeobox-containing gene expressed in a time- and cell-specific manner during embryogenesis. We have generated transgenic mice that ectopically express Hox-1.1 from the chicken beta-actin promoter. In these mice Hox-1.1 expression was changed to an almost ubiquitous pattern. Ectopic expression of Hox-1.1 leads to death of the transgenic animals shortly after birth and is associated with multiple craniofacial anomalies, such as cleft palate, open eyes at birth, and nonfused pinnae. This phenotype is similar to the effects seen after systemic administration of retinoic acid during gestation. This suggests that retinoic acid embryopathy and the specific developmental defects caused by ectopic expression of a potential developmental control gene share a common pathogenic mechanism. [less ▲]

Villin induces microvilli growth and actin redistribution in transfected fibroblasts.

in Cell (1989), 59(3), 461-75

The function of villin, an actin-binding protein, has been investigated by transfecting fibroblasts with cloned human cDNAs encoding wild-type villin or functional villin domains. Synthesis of large ... [more ▼]

The function of villin, an actin-binding protein, has been investigated by transfecting fibroblasts with cloned human cDNAs encoding wild-type villin or functional villin domains. Synthesis of large amounts of villin induced the growth of numerous long microvilli on cell surfaces together with the redistribution of F-actin. These microvilli contained a cytoskeleton of F-actin, and their appearance was frequently accompanied by the disappearance of stress fibers. The complete villin gene sequence was required to exert its morphogenic effect. Villin lacking one actin-binding domain (113 amino acids), located at its carboxyterminal end, did not induce growth if microvilli or stress fiber disruption. Our results indicate that villin plays a key role in vivo in the morphogenesis of microvilli. [less ▲]

Action of atrial natriuretic peptide and angiotensin II on the myocardium: studies in isolated rat ventricular cardiomyocytes.

in Biochemical and biophysical research communications (1989), 163(3), 1435-43

Isolated calcium-tolerant rat ventricular cardiomyocytes were used to characterize the effects of atrial natriuretic peptide (ANP), Angiotensin II (AII) and their interaction on the myocardial contraction ... [more ▼]

Isolated calcium-tolerant rat ventricular cardiomyocytes were used to characterize the effects of atrial natriuretic peptide (ANP), Angiotensin II (AII) and their interaction on the myocardial contraction-/relaxation pattern free of interference from other types of cardiac cells. Binding of 125I-ANP showed a KD of 12 pM and approximately 600 binding sites per cell. At 37 degrees C (rate 140 bpm) ANP decreased the contraction maximum with an EC50 of about 70 pM, maximal decrease was 35%. ANP (10(-7) M) raised cellular cyclic-GMP from 0.76+/-0.12 to 1.32+/-0.13 pmole/10(6) cells (73%, p less than 0.05). Angiotensin II increased contractility by a maximum of 32% at 10(-7) M; the EC50 was 8 x 10(-10) M. AII markedly delayed relaxation (reduction of maximum relaxation velocity from 0.092 to 0.063 mm/s; p less than 0.05). ANP (10(-7) M) increased the effect of AII (10(-8) M) on contractility by 66% without changing relaxation parameters significantly. This unexpected interaction may be relevant in pathological conditions where both AII and ANP are stimulated, such as heart failure or secondary hypertension. [less ▲]

Verslag AERA-congres 1989 te San Francisco. Divisie F: History and historiography.

in Pedagogische Studiën: Tijdschrift voor Onderwijskunde en Opvoedkunde (1989), 66

A family of octamer-specific proteins present during mouse embryogenesis: evidence for germline-specific expression of an Oct factor.

in EMBO Journal (1989), 8(9), 2543-50

We have analysed various adult organs and different developmental stages of mouse embryos for the presence of octamer-binding proteins. A variety of new octamer-binding proteins were identified in ... [more ▼]

We have analysed various adult organs and different developmental stages of mouse embryos for the presence of octamer-binding proteins. A variety of new octamer-binding proteins were identified in addition to the previously described Oct1 and Oct2. Oct1 is ubiquitously present in murine tissues, in agreement with cell culture data. Although Oct2 has been described as a B-cell-specific protein, similar complexes were also found with extracts from brain, kidney, embryo and sperm. In embryo and brain at least two other proteins, Oct3 and Oct7, are present. A new microextraction procedure allowed the detection of two maternally expressed octamer-binding proteins, Oct4 and Oct5. Both proteins are present in unfertilized oocytes and embryonic stem cells, the latter containing an additional protein, Oct6. Whereas Oct4 was not found in sperm or testis, it is expressed in male and female primordial germ cells. Therefore Oct4 expression is specific for the female germline at later stages of germ cell development. Our results indicate that a family of octamer-binding proteins is present during mouse development and is differentially expressed during early embryogenesis. Protease clipping experiments of Oct4 and Oct1 suggest that both proteins contain similar DNA-binding domains. [less ▲]

The detection and perveived intensity of noxious thermal stimuli in monkey and human

in Journal of Neurophysiology (1989), 62(2), 429-436

Zur Alters- und Bereichsspezifität subjektiven Alterserlebens.

in Zeitschrift für Entwicklungspsychologie und Padagogische Psychologie (1989), 21(4)

Peripheral nerve function in children with end-stage renal failure

in Pediatric Nephrology (1989), 3(2), 175-178

Information on clinical and subclinical peripheral neuropathy in children with end-stage renal failure (ESRF) is scarce. We have studied the presence of clinical and subclinical peripheral neuropathy in ... [more ▼]

Information on clinical and subclinical peripheral neuropathy in children with end-stage renal failure (ESRF) is scarce. We have studied the presence of clinical and subclinical peripheral neuropathy in children with ESRF comparing recently developed non-invasive methods with the measurement of nerve conduction velocities. Twelve children (7 boys, 5 girls; age range: 5-17 years; duration of haemodialysis: 0.5-60 months) participated. Thermal discrimination threshold (TDT) and vibration perception threshold (VPT) were determined twice before and after haemodialysis in each patient. Peroneal nerve conduction velocity was determined once before haemodialysis. No clinical or subclinical peripheral neuropathy was observed in any of the children. Except for two slightly increased TDT values after haemodialysis all results were within the normal range. No correlation was found with age or duration of haemodialysis and no association was found between the three methods. VPT values showed a significant improvement after haemodialysis treatment, although all VPT values were in the normal range. This suggests that haemodialysis has an influence on cutaneous sensation, but further study is needed to confirm this observation. Longitudinal investigations will be necessary to evaluate whether TDT and VPT determinations can be used for early screening of clinical and subclinical neuropathy in children with ESRF. © 1989 IPNA. [less ▲]

[Increased atrial natriuretic peptide in essential hypertension--relation to right atrial pressure behavior].

in Klinische Wochenschrift (1989), 67(15), 756-61

The role of atrial natriuretic peptide (ANP) in the pathogenesis of essential hypertension has not yet entirely been clarified. We investigated whether the increase of ANP in essential hypertension may be ... [more ▼]

The role of atrial natriuretic peptide (ANP) in the pathogenesis of essential hypertension has not yet entirely been clarified. We investigated whether the increase of ANP in essential hypertension may be explained by elevated right atrial pressures and/or a different relationship between right atrial pressures and ANP secretion. Patients with stable essential hypertension undergoing right and left heart catheterization because of suspected coronary heart disease had significantly higher ANP levels than normotensives: 58.7 +/- 6.7 pg/ml in hypertensives versus 42.0 +/- 4.1 pg/ml in normotensives (p less than 0.01). Matching hypertensives with normotensives at identical levels of left ventricular enddiastolic pressure revealed significantly higher mean pulmonary artery pressures in hypertensives. Right atrial diastolic pressure (v-wave) after matching for LVEDP was 4.8 +/- 0.5 mm Hg in hypertensives and 3.1 +/- 0.2 mm Hg in normotensives (p less than 0.05). In addition, at any given mean right atrial pressure hypertensives showed higher ANP levels than normotensives. These results demonstrate that hypertensives exhibit raised pressures in the pulmonary artery independent of left ventricular pressure load. The elevation in right atrial pressures and the steeper relationship between these pressures and ANP are a suitable explanation for raised ANP levels in hypertension. ANP in essential hypertension may represent a counterregulation against elevated pulmonary resistance. [less ▲]

Review of: M. Toolan. Narrative

in Journal of Literary Semantics (1989), 18

Implizites und explizites Gedächtnis beim Bearbeiten visueller Vorstellungen.

in Sprache und Kognition (1989), 8(2), 51-64

«L'alone delle cose in Daniele Del Giudice. Per una narrativa ricalibrata»

in Restant (1989)

Der Dollar als internationale Schlüsselwährung: Ursachen und Perspektiven

in Kredit und Kapital (1989)

Der Wal ist kein Fisch, und doch ist er ein „Walfisch“. Antwort auf die Essenz der Emotionen: Bedeutungskonstituenten der Alltagssprache oder multikomponentiale Verlaufsmuster?

in Sprache und Kognition (1989), 8

Discusses some of the points raised in K. Scherer's reply to the authors' criticism of his component process model of the emotions (both in Sprache & Kognition 1989, 8 (1)). The first point considered is ... [more ▼]

Discusses some of the points raised in K. Scherer's reply to the authors' criticism of his component process model of the emotions (both in Sprache & Kognition 1989, 8 (1)). The first point considered is Scherer's doubts about the hypothesis that the explication of the semantic structures of the words used to describe emotions in everyday language forms the precondition for scientific concept formation and empirical research into specific emotions in psychology. Then his doubts about the possibility of implementing a standardized language analysis in this context are considered. He justifies these doubts by pointing to the interindividual differences in the use of words describing emotions. Finally, a reply is given to his doubts about the implications of using language analysis for psychological research on specific emotions in different language communities and cultures. [less ▲]

Les droits en France du créateur d'information

in Revue Internationale de Droit Economique (1989)

Gegenstandsverständnis und Zielsetzungen kognitiver Ansätze zur Analyse spezifischer Emotionen. Anmerkungen zum Komponentenprozeß- Modell von K. R. Scherer

in Sprache und Kognition (1989), 8(1), 9-18

Uses the example of K. R. Scherer's component process model to critically discuss the theoretical and epistemological problems in cognitive approaches to the analysis of specific emotions. First, a ... [more ▼]

Uses the example of K. R. Scherer's component process model to critically discuss the theoretical and epistemological problems in cognitive approaches to the analysis of specific emotions. First, a syndromatic understanding of emotions is discussed in which expressive and physiological patterns of reactions as well as perceptions are regarded as necessary components of a specific emotion. Then three of the goals of cognitive approaches named by Scherer are discussed: (1) the scientific conceptualization of specific emotions, (2) the analysis of the semantics of emotion terms, and (3) the causal analysis of specific emotions. In contrast to Scherer's concept, an explicit analysis of natural-language emotion terms is considered to be an essential basis for the scientific conceptualization of specific emotions. The latter is seen as a requirement for differntiating between empirical and pseudoempirical research. [less ▲]

Methodisch Handelen in Beroep en Opleiding.

in Gamma. (1989), 39(4), 102-105

Structure, expression and chromosomal localization of Zfp-1, a murine zinc finger protein gene.

in Nucleic Acids Research (1989), 17(24), 10427-38

Zinc finger proteins (Zfp) are encoded by a large family of genes present in many organisms including yeast and human. Some of them are transcriptional activators and bind specifically to DNA by zinc ... [more ▼]

Zinc finger proteins (Zfp) are encoded by a large family of genes present in many organisms including yeast and human. Some of them are transcriptional activators and bind specifically to DNA by zinc mediated folded structures commonly known as zinc fingers. The Drosophila Kruppel (Kr) is a segmentation gene and encodes a zinc finger protein. Using a probe from the finger domain of Kr, we have isolated a structurally related gene Zfp-1 from the mouse. In this paper, we report the complete nucleotide sequence of two cDNA clones and the amino acid sequence deduced from them. The putative Zfp-1 protein contains in addition to 7 zinc fingers, two helix-turn-helix motifs. During murine embryogenesis, the Zfp-1 was found to express at a peak level in day 12 embryos. The ubiquitously expressed Zfp-1 gene is located in the 16q region on mouse chromosome 8, between the uvomorulin and the tyrosine amino transferase genes. [less ▲]

Murine Genes with homology to Drosophila segmentation genes.

in Development (1988), 0(104), 181-186

Bespreking van Hoksbergen, R.A.C., R. v.d. Meer en G.P. Schoon (eds), Adolescenten in vele gedaanten. Bijdragen over adolescentie en adolescentenzorg.

in Jeugd en samenleving : maandblad (1988), 18(10), 559-561

Verslag van het AERA-Congres 1988 te New Orleans: The John Dewey Society.

in Pedagogische Studiën: Tijdschrift voor Onderwijskunde en Opvoedkunde (1988), 65(11), 453-454

Polizei, Protest und Eskalation: Die Bedeutung der Konflikterfahrungen junger Polizeibeamter

in Neue Soziale Bewegungen und Kontrolle (1988), 1(2), 11-20

undulated, a mutation affecting the development of the mouse skeleton, has a point mutation in the paired box of Pax 1.

in Cell (1988), 55(3), 531-5

undulated (un) homozygous mice exhibit vertebral malformations along the entire rostro-caudal axis. Pax 1, a murine paired box-containing gene, is expressed in ventral sclerotome cells and later in ... [more ▼]

undulated (un) homozygous mice exhibit vertebral malformations along the entire rostro-caudal axis. Pax 1, a murine paired box-containing gene, is expressed in ventral sclerotome cells and later in intervertebral disks along the entire vertebral column. We localized the Pax 1 gene on chromosome 2 between beta 2-microglobulin and the agouti locus to an area where un maps. DNA analysis of the un mutant revealed a point mutation in a highly conserved part of the paired box of Pax 1, leading to a Gly-Ser replacement. The chromosomal location and the mutation in the paired box of un mice in conjunction with Pax 1 gene expression in wild-type mice implicate a causative role of Pax 1 in generation of the vertebral column. [less ▲]

Aspects politiques de la "Réforme" monastique en Lotharingie. Le cas des abbayes de Saint-Maximin de Trèves

in Revue Bénédictine (1988), 98

Auslösung und Dämpfung von Feindseligkeit

in Untersuchungen des Psychologischen Dienstes der Bundeswehr (1988), 23

Auf der Basis einer kognitionspsychologischen Analyse verschiedener aggressionsbezogener Gefühle (Wut, Ärger, Hass, Neid, Empörung) werden bei Wehrpflichtigen Bedingungen der Entstehung und Dämpfung von ... [more ▼]

Auf der Basis einer kognitionspsychologischen Analyse verschiedener aggressionsbezogener Gefühle (Wut, Ärger, Hass, Neid, Empörung) werden bei Wehrpflichtigen Bedingungen der Entstehung und Dämpfung von Feindseligkeit im Sinne von Hass gegenüber einem Vorgesetzten untersucht. Drei Indikatoren der Feindseligkeit wurden erhoben: (1) positive Gefühle bei einer Schädigung des Vorgesetzten, (2) Häufigkeit unwillkürlich interferierender Schädigungsvorstellungen und (3) negative Bewertung des Vorgesetzten. Feindseligkeit wurde im Wesentlichen als Funktion von fünf Variablen erwartet: (1) erlebte Beeinträchtigung durch den Vorgesetzten, (2) wahrgenommene Absichtlichkeit der Beeinträchtigung, (3) wahrgenommene Machtlosigkeit gegenüber dem Vorgesetzten, (4) Ablehnung von Rechtfertigungsgründen für das Handeln des Vorgesetzten und (5) Widerstandswille gegenüber diesem. Dämpfende Effekte auf Feindseligkeit sollten erlebte Sicherheit in sozialen Kontexten haben (Selbstvertrauen, wahrgenommene Unterstützung durch Kameraden oder höhere Vorgesetzte, Gerechtigkeit in der eigenen Einheit) sowie positive Bewertung der Bundeswehr und der Wehrpflicht. Alle Variablen wurden mit eigens konstruierten Fragebogen an einer Untersuchungsstichprobe von 426 Soldaten aus fünf Ausbildungsquartalen und unterschiedlich "harten" Einheiten erhoben. Wesentliche Ergebnisse waren: Die Kernvariablen wirkten in erwarteter Richtung auf Feindseligkeit. Die Indikatoren für erlebte Sicherheit wirkten insgesamt erwartungsgemäß dämpfend auf Feindseligkeit, was die direkten linearen Effekte anbelangt. Die Moderatoreffekte von Sicherheitsvariablen auf die Beziehung zwischen erlebter Beeinträchtigung und Feindseligkeit waren größtenteils erwartungswidrig: je höher die Sicherheit, um so grösser die Effekte erlebter Beeinträchtigung auf Feindseligkeit. Die Validität der Feindseligkeitsmaße wird diskutiert, und praktische Schlussfolgerungen, die die Vermeidung oder Dämpfung von Feindseligkeit betreffen, werden gezogen. [less ▲]

Zur strukturellen Repräsentation alltagssprachlicher Person- und Verhaltensbeschreibungen

in Zeitschrift für Sozialpsychologie (1988), 19

The present paper is focused on the topic of a structural representation of adjectives describing interpersonal behavior in ordinary Janguage. 40 students of the University of Saarland were presented 117 ... [more ▼]

The present paper is focused on the topic of a structural representation of adjectives describing interpersonal behavior in ordinary Janguage. 40 students of the University of Saarland were presented 117 adjectives selected on the basis of studies in the domain of verbal behavior descriptions by considering the concept of frequency of use. Subjects were asked to partition this set of adjectives into groups under the aspect of similarity of meaning. In order to analyse the relations between the investigated words and to provide a representation of all relevant relations simultaneously, the data of the sorting-task were inspected by hierarchical dustering and multidimensional scaling techniques. Thus a dimensional configuration reflecting inter-dass-relations was obtained and various dustering methods generated concordant dasses of adjectives which appeared to be interpretable at two different Ievels of analysis. [less ▲]

On the accuracy of the Platzman's charting for loading estimations

in Marées Terrestres Bulletin d'Informations (1988), (101), 7010-7018

Urinary C-peptide: A useful tool for evaluating the endogenous insulin reserve in cohort and longitudinal studies of diabetes in childhood

in Annals of Clinical Biochemistry (1988), 25(5), 552-559

Increasing research into the remission phase of type I diabetes mellitus stresses the importance of a non-traumatic and reliable method for the evaluation of endogenous insulin production. We compared 24 ... [more ▼]

Increasing research into the remission phase of type I diabetes mellitus stresses the importance of a non-traumatic and reliable method for the evaluation of endogenous insulin production. We compared 24-h urinary C-peptide excretion (UCE) with plasma C-peptide values before and after stimulation with 1 mg glucagon in 24 type I diabetic children. Fasting plasma C-peptide values and stimulated plasma C-peptide values showed a linear correlation with 24 h UCE. Mean plasma C-peptide levels correlated inversely with the exogenous insulin dose. A slightly better correlation was found between the exogenous insulin dose and 24 h UCE. Control data of 24 h UCE were obtained from healthy siblings. A linear correlation with ages was found up to 10 years of age above which UCE values seem to reach a plateau. This effect of age, as well as the frequency of sampling was taken into account in the derivation of 95% reference intervals for UCE. The measurement of 24 h UCE appears to be a useful parameter to assess endogenous insulin production in diabetic children, provided that age is taken into account. [less ▲]

Dewey's Logic: A Reconstructive View on the Relation between Theory and Practice.

in Insights (1988), 24(1), 6-7

Insulin antibodies in diabetic children before treatment: A marker for islet B-cell destruction?

in Diabetic Medicine: A Journal of the British Diabetic Association (1988), 5(5), 441-443

Insulin antibodies were measured in the sera of 28 newly diagnosed diabetic children (age 8.0 ± 4.0 (±SD) years) prior to insulin therapy and after 3, 6, 9, and 12 months. The levels at diagnosis and ... [more ▼]

Insulin antibodies were measured in the sera of 28 newly diagnosed diabetic children (age 8.0 ± 4.0 (±SD) years) prior to insulin therapy and after 3, 6, 9, and 12 months. The levels at diagnosis and after 12 months were compared to endogenous insulin production at onset and after 12 to 14 months. Endogenous insulin production was evaluated through the measurement of 24-h urinary C-peptide excretion, fasting plasma C-peptide levels and plasma C-peptide levels after glucagon stimulation. Insulin antibodies were detected in 29% of the patients (8 out of 28). In all but one patient antibodies binding porcine and human insulin were detected. No relationship was found between the presence of antibodies binding human or porcine insulin at diagnosis and age. After 1 year 27 out of 28 patients presented insulin antibodies. No relationship was found between the presence of insulin antibodies before therapy and 1 year after therapy. Insulin antibodies prior to diagnosis showed no relationship with the urinary C-peptide excretion at diagnosis (with antibodies 67 ± 27%, without antibodies 76 ± 11%). However, after 1 year significantly lower urinary C-peptide excretions were found in patients with insulin antibodies prior to therapy (with antibodies, 17 ± 7%, without antibodies, 31 ± 5%, p < 0.02). Peak plasma C-peptide levels after 1 year were possibly lower in patients with insulin antibodies before treatment (with antibodies 0.17 ± 0.06 nmol/l, without antibodies 0.26 ± 0.04 nmol/l, p < 0.1). Fasting C-peptide levels did not differ significantly between the two groups after 1 year of therapy (with antibodies 0.11 ± 0.03 nmol/l, without antibodies 0.14 ± 0.02 nmol/l). Thus, insulin auto-antibodies may be a marker for islet B-cell destruction in Type 1 diabetes. [less ▲]