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See detailReview of: D. Birch. The Language of Drama
Weber, Jean-Jacques UL

in BELL. Belgian Journal of English Language and Literatures (1992), 1

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See detailLes polarisations de Vergne dans une algèbre de Lie exponentielle
Molitor-Braun, Carine UL

in Travaux Mathématiques (1992), 4

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See detailClinical and laboratory features of type 1 diabetic children at the time of diagnosis
Levy-Marchal, C.; Papoz, L.; De Beaufort, Carine UL et al

in Diabetic Medicine: A Journal of the British Diabetic Association (1992), 9

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See detailTorsion sur des familles de courbes de genre g
Leprévost, Franck UL

in Manuscripta Mathematica (1992), 75

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See detailno-bridge of drosophila melanogaster, - portrait of a structural brain mutant of the central complex
Strauß, Roland; Hanesch, Ulrike UL; Kinkelin, Martin et al

in Journal of Neurogenetics (1992), 8

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See detailFeiten en waarden in de ontwikkeling van de Nederlandse academische pedagogiek. Een opmaat voor pedagogisch wetenschapsonderzoek.
Biesta, Gert UL; Miedema, S.

in Pedagogisch Tijdschrift: Forum voor Opvoedkunde (1992), 17

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See detailMolecular biology of oncogenes and cardiovascular hypertrophy.
Neyses, Ludwig UL; Vetter, H.

in Journal of hypertension (1992), 10(12), 1447-52

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See detailWHATS IN A GENOME
BORK, P.; OUZOUNIS, C.; SANDER, C. et al

in Nature (1992), 358(6384), 287-287

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See detailDie Korrektion verwahrloster Kinder im Königreich Württemberg zu Beginn des 19. Jahrhunderts
Priem, Karin UL

in Zeitschrift für Wurttembergische Landesgeschichte (1992), 51

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See detailFremdenfeindliche Gewalt: Entwicklung, Strukturen, Eskalationsprozesse
Willems, Helmut UL

in Gruppendynamik (1992), 23. Jg(4), 433-448

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See detailIndividual differences in the perception of bodily sensations: The role of trait anxiety and coping style
Steptoe, Andrew; Vögele, Claus UL

in Behaviour research and therapy (1992), 30

Thirty young women participated in an experiment in which heart rate, blood pressure, respiration rate, skin conductance level and palmar sweat index were monitored at rest and during the administration ... [more ▼]

Thirty young women participated in an experiment in which heart rate, blood pressure, respiration rate, skin conductance level and palmar sweat index were monitored at rest and during the administration of mental arithmetic, mirror drawing and cold pressor tasks. The accuracy of perception of somatic states was estimated by calculating within-subject correlations between four bodily sensations (racing heart, high blood pressure, shortness of breath and sweaty hands) and corresponding physiological parameters, assessed on eight occasions during the experiment. The accuracy of heart rate perception was highest, with a mean correlation between actual heart rate and ratings of racing heart of 0.76 and 66% of participants showing significant within-subject effects. The mean accuracy was 0.55 for systolic blood pressure, 0.48 for respiration rate, 0.47 for skin conductance level, and 0.64 for palmar sweat index. Accurate perception across physiological parameters did not cluster within individuals, and was not dependent on the range either of physiological changes or sensation ratings. Trait anxiety was not significantly associated with accuracy of somatic perception. Subjects with high trait anxiety reported larger increases in shortness of breath during tasks than did low anxious subjects, but this was not reflected in objective physiological measures. Information-seeking coping style, indexed by the monitoring scale of the Miller Behavioral Style Scale, was related to the accuracy of perception of skin conductance level and heart rate. The use of within-subject correlational strategies for assessing individual differences in perception of bodily states is discussed. [less ▲]

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See detailEpithelial modulation of thromboxane A2 and PAF involvement in IgE- and IgG-mediated guinea pig anaphylaxis
Bertrand, C.; Tschirhart, Eric UL; Landry, Y.

in Immunopharmacology (1992), 22(2), 115-25

The role of prostanoids and platelet-activating factor (PAF) was studied in the in vitro response of guinea pig trachea to immunochallenge according to the presence or the absence of the epithelial layer ... [more ▼]

The role of prostanoids and platelet-activating factor (PAF) was studied in the in vitro response of guinea pig trachea to immunochallenge according to the presence or the absence of the epithelial layer and to the sensitization procedure leading to the preferential synthesis of immunoglobulin E (IgE) or immunoglobulin G (IgG) antibodies. Indomethacin, a cyclooxygenase inhibitor, potentiated the antigen-induced contractions both in IgE and IgG models, suggesting the involvement of relaxant prostaglandins (PGs), independently of the presence of the airway epithelium. UK-38485, a thromboxane synthetase inhibitor, did not modify the tracheal response to antigen in the IgE model. However, this compound enhanced the maximum contractile response to antigen of the intact tracheal strips of IgG-sensitized guinea pig, but reduced the contractile response of the epithelium-free tracheal strips. Two potent non-structurally related PAF antagonists, Ro 19-3704 and BN 52021, reduced antigen-induced contraction of the epithelium-free tracheal strips in the IgE model. In contrast, these compounds did not affect the contractile responses of the preparations in the IgG model. These results suggest the selective implication of thromboxane A2 and PAF, in IgG- and IgE-mediated guinea pig anaphylaxis respectively. Finally, these results indicate that thromboxane A2 (TXA2) and PAF are potent inducers of epithelium-derived mediators. [less ▲]

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See detailAngiotensin II induces formation of the early growth response gene-1 protein in rat vascular smooth muscle cells.
Sachinidis, A.; Weisser, P.; Ko, Y. et al

in FEBS letters (1992), 313(2), 109-12

The effect of angiotensin II (Ang II) on the early growth response gene-1 (Egr-1) mRNA, on the Egr-1 protein and on the phosphoinositide PI turnover signalling system was investigated in the presence and ... [more ▼]

The effect of angiotensin II (Ang II) on the early growth response gene-1 (Egr-1) mRNA, on the Egr-1 protein and on the phosphoinositide PI turnover signalling system was investigated in the presence and absence of EXP3174, a potent non-peptide Ang II receptor antagonist. Ang II induced an accumulation of 3.4 kb Egr-1 mRNA and the 80 kDa Egr-1 protein, with a maximum at 30 min and 60 min, respectively. EXP3174 blocked the Ang II-induced increase of inositol phosphates, Egr-1 mRNA and the Egr-1 protein, suggesting the involvement of the PI signalling system by the expression of the Egr-1 gene. [less ▲]

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See detailQuestions actuelles en droit allemand des sociétés : de quoi nourrir la réflexion au sein d'un droit belge en mutation
Corbisier, Isabelle UL

in Revue Pratique des Sociétés Civiles et Commerciales (1992), (3), 153-209

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See detailSELECTION OF REPRESENTATIVE PROTEIN DATA SETS
HOBOHM, U.; SCHARF, M.; Schneider, Reinhard UL et al

in Protein Science : A Publication of the Protein Society (1992), 1(3), 409-417

The Protein Data Bank currently contains about 600 data sets of three-dimensional protein coordinates determined by X-ray crystallography or NMR. There is considerable redundancy in the data base, as many ... [more ▼]

The Protein Data Bank currently contains about 600 data sets of three-dimensional protein coordinates determined by X-ray crystallography or NMR. There is considerable redundancy in the data base, as many protein pairs are identical or very similar in sequence. However, statistical analyses of protein sequence-structure relations require nonredundant data. We have developed two algorithms to extract from the data base representative sets of protein chains with maximum coverage and minimum redundancy. The first algorithm focuses on optimizing a particular property of the selected proteins and works by successive selection of proteins from an ordered list and exclusion of all neighbors of each selected protein. The other algorithm aims at maximizing the size of the selected set and works by successive thinning out of clusters of similar proteins. Both algorithms are generally applicable to other data bases in which criteria of similarity can be defined and relate to problems in graph theory. The largest nonredundant set extracted from the current release of the Protein Data Bank has 155 protein chains. In this set, no two proteins have sequence similarity higher than a certain cutoff (30% identical residues for aligned subsequences longer than 80 residues), yet all structurally unique protein families are represented. Periodically updated lists of representative data sets are available by electronic mail from the file server "netserv @ embl-heidelberg.de." The selection may be useful in statistical approaches to protein folding as well as in the analysis and documentation of the known spectrum of three-dimensional protein structures. [less ▲]

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See detailPurification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen
Oehm, A.; Behrmann, Iris UL; Falk, W. et al

in Journal of Biological Chemistry (1992), 267(15), 10709-15

The APO-1 antigen as defined by the mouse monoclonal antibody anti-APO-1 was previously found to be expressed on the cell surface of activated human T and B lymphocytes and a variety of malignant human ... [more ▼]

The APO-1 antigen as defined by the mouse monoclonal antibody anti-APO-1 was previously found to be expressed on the cell surface of activated human T and B lymphocytes and a variety of malignant human lymphoid cell lines. Cross-linking of the APO-1 antigen by anti-APO-1 induced programmed cell death, apoptosis, of APO-1 positive cells. To characterize the APO-1 cell surface molecule and to better understand its role in induction of apoptosis, the APO-1 protein was purified to homogeneity from membranes of SKW6.4 B lymphoblastoid cells by solubilization with sodium deoxycholate, affinity chromatography with anti-APO-1 antibody, and reversed phase high performance liquid chromatography. Each purification step was followed by an APO-1-specific solid phase enzyme-linked immunosorbent assay using the monoclonal antibody anti-APO-1. In sodium dodecyl sulfate-polyacrylamide gel electrophoresis, the APO-1 antigen was found to be a membrane glycoprotein of 48-kDa. Endoproteinase-cleaved peptides of the APO-1 protein were subjected to amino acid sequencing, and corresponding oligonucleotides were used to identify a full-length APO-1 cDNA clone from an SKW6.4 cDNA library. The deduced amino acid sequence of APO-1 showed sequence identity with the Fas antigen, a cysteine-rich transmembrane protein of 335 amino acids with significant similarity to the members of the tumor necrosis factor/nerve growth factor receptor superfamily. The APO-1 antigen was expressed upon transfection of APO-1 cDNA into BL60-P7 Burkitt's lymphoma cells and conferred sensitivity towards anti-APO-1-induced apoptosis to the transfectants. [less ▲]

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See detail«Slechtsprekenden en hardhorigen»
Roelens, Nathalie UL

in ALW-Cahier (1992)

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See detailWaardenburg's syndrome patients have mutations in the human homologue of the Pax-3 paired box gene.
Tassabehji, M.; Read, A. P.; Newton, V. E. et al

in Nature (1992), 355(6361), 635-6

Waardenburg's syndrome (WS) is an autosomal dominant combination of deafness and pigmentary disturbances, probably caused by defective function of the embryonic neural crest. We have mapped one gene for ... [more ▼]

Waardenburg's syndrome (WS) is an autosomal dominant combination of deafness and pigmentary disturbances, probably caused by defective function of the embryonic neural crest. We have mapped one gene for WS to the distal part of chromosome 2. On the basis of their homologous chromosomal location, their close linkage to an alkaline phosphatase gene, and their related phenotype, we suggested that WS and the mouse mutant Splotch might be homologous. Splotch is caused by mutation in the mouse Pax-3 gene. This gene is one of a family of eight Pax genes known in mice which are involved in regulating embryonic development; each contains a highly conserved transcription control sequence, the paired box. Here we show that some families with WS have mutations in the human homologue of Pax-3. Mutations in a related gene, Pax-6, which, like Pax-3, has both a paired box and a paired-type homeobox sequence, cause the Small-eye mutation in mice and aniridia in man. Thus mutations in the Pax genes are important causes of human developmental defects. [less ▲]

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See detailMultiple Invariance ESPRIT
Swindlehurst, A.; Ottersten, Björn UL; Roy, R. et al

in IEEE Transactions on Signal Processing (1992), SP-40(4), 867881

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See detailSequence analysis of polymerase chain reaction amplified t(14;18) chromosomal breakpoints in formalin fixed, paraffin wax embedded follicular lymphoma.
Volkenandt, M.; Koch, O.; Fanin, R. et al

in Journal of clinical pathology (1992), 45(3), 210-2

AIMS: To determine whether junctional sequences of rearranged chromosomes can be amplified by use of the polymerase chain reaction (PCR) and whether direct sequence analysis of the PCR products is ... [more ▼]

AIMS: To determine whether junctional sequences of rearranged chromosomes can be amplified by use of the polymerase chain reaction (PCR) and whether direct sequence analysis of the PCR products is possible, using DNA from formalin fixed, paraffin wax embedded biopsy specimens. METHODS: DNA was extracted from paraffin wax embedded, formalin fixed lymphoma specimens, and junctional sequences of rearranged chromosomes were amplified by the PCR. The products were used as templates for asymmetrical PCR. Subsequently, direct sequence analysis was performed using the chain termination method. RESULTS: Formalin fixed, paraffin wax embedded biopsy specimens and PCR amplification could be used to determine the nucleotide sequences of junctional regions of rearranged chromosomes t(14;18) from patients with follicular lymphoma. CONCLUSION: The identification of junctional sequences of the translocation in follicular lymphoma provides a molecular "fingerprint" of t(14;18) of the lymphoma of an individual patient and can be used for the detection of clone specific DNA in any biopsy tissue obtained from the patient. The strategy used for rapid sequence analysis of PCR amplified DNA sequences will be useful in many areas of molecular pathology. [less ▲]

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See detailDATABASE OF HOMOLOGY-DERIVED PROTEIN STRUCTURES AND THE STRUCTURAL MEANING OF SEQUENCE ALIGNMENT
SANDER, C.; Schneider, Reinhard UL

in Proteins (1991), 9(1), 56-68

The database of known protein three-dimensional structures can be significantly increased by the use of sequence homology, based on the following observations. (1) The database of known sequences ... [more ▼]

The database of known protein three-dimensional structures can be significantly increased by the use of sequence homology, based on the following observations. (1) The database of known sequences, currently at more than 12,000 proteins, is two orders of magnitude larger than the database of known structures. (2) The currently most powerful method of predicting protein structures is model building by homology. (3) Structural homology can be inferred from the level of sequence similarity. (4) The threshold of sequence similarity sufficient for structural homology depends strongly on the length of the alignment. Here, we first quantify the relation between sequence similarity, structure similarity, and alignment length by an exhaustive survey of alignments between proteins of known structure and report a homology threshold curve as a function of alignment length. We then produce a database of homology-derived secondary structure of proteins (HSSP) by aligning to each protein of known structure all sequences deemed homologous on the basis of the threshold curve. For each known protein structure, the derived database contains the aligned sequences, secondary structure, sequence variability, and sequence profile. Tertiary structures of the aligned sequences are implied, but not modeled explicitly. The database effectively increases the number of known protein structures by a factor of five to more than 1800. The results may be useful in assessing the structural significance of matches in sequence database searches, in deriving preferences and patterns for structure prediction, in elucidating the structural role of conserved residues, and in modeling three-dimensional detail by homology. [less ▲]

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See detailSubspace Based Detection for Linear Structural Relations
Viberg, M.; Ottersten, Björn UL; Kailath, T.

in Journal of Combinatorics, Information and System Sciences (1991), 16(2-3), 170189

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See detailSeparate elements cause lineage restriction and specify boundaries of Hox-1.1 expression.
Puschel, A. W.; Balling, Rudi UL; Gruss, P.

in Development (1991), 112(1), 279-87

The Hox genes are a class of putative developmental control genes that are thought to be involved in the specification of positional identity along the anteroposterior axis of the vertebrate embryo. It is ... [more ▼]

The Hox genes are a class of putative developmental control genes that are thought to be involved in the specification of positional identity along the anteroposterior axis of the vertebrate embryo. It is apparent from their expression pattern that their regulation is dependent upon positional information. In a previous analysis of the Hox-1.1 promoter in transgenic mice, we identified sequences that were sufficient to establish transgene expression in a specific region of the embryo. The construct used, however, did not contain enough regulatory sequences to reproduce all aspects of Hox-1.1 expression. In particular, neither a posterior boundary nor a restriction of expression to prevertebrae was achieved. Here we show correct regulation by Hox-1.1 sequences in transgenic mice and identify the elements responsible for different levels of control. Concomitant with the subdivision of mesodermal cells into different lineages during gastrulation and organogenesis, Hox-1.1 expression is restricted to successively smaller sets of cells. Distinct elements are required at different stages of development to execute this developmental programme. One position-responsive element (130 bp nontranslated leader) was shown to be crucial for the restriction of expression not only along the anteroposterior axis of the embryo, setting the posterior border, but also along the dorsoventral axis of the neural tube and to the lineage giving rise to the prevertebrae. Thus, Hox-1.1 expression is established in a specific region of the embryo and in a specific lineage of the mesoderm by restricting the activity of the promoter by the combined effect of several regulatory elements. [less ▲]

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See detailIncidence of insulin dependent diabetes in children of school age in Lorraine
De Beaufort, Carine UL; Cecchi-Tenerini, R.; Clerc, R. et al

in Archives Françaises de Pédiatrie (1991), 48(3), 228

[No abstract available]

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See detailActivation of Gi-like proteins, a receptor-independent effect of kinins in mast cells
Bueb, Jean-Luc UL; Mousli, M.; Bronner, C. et al

in Molecular Pharmacology (1991), 38(6), 816-22

The peptide hormones bradykinin and kallidin (Lys-bradykinin), as well as their analogues [des-Arg9]-bradykinin, a selective B1 agonist, [des-Arg9,Leu8]-bradykinin, a selective B1 antagonist, and [Thi5,8 ... [more ▼]

The peptide hormones bradykinin and kallidin (Lys-bradykinin), as well as their analogues [des-Arg9]-bradykinin, a selective B1 agonist, [des-Arg9,Leu8]-bradykinin, a selective B1 antagonist, and [Thi5,8,D-Phe7]-bradykinin and D-Arg0-[Hyp3,D-Phe7]-bradykinin, two selective B2 antagonists, induced rapid histamine release from purified rat peritoneal mast cells. In contrast, the N-terminal fragment bradykinin-(1-5) was inactive. These peptides also activate the GTPase activity of GTP-binding proteins (G proteins) (Go/Gi) purified from calf brain, with an order of potency identical to that observed on mast cells, [Thi5,8,D-Phe7]-bradykinin much greater than kallidin greater than bradykinin greater than D-Arg0-[Hyp3,D-Phe7]-bradykinin greater than [des-Arg9]-bradykinin greater than [des-Arg9,Leu8]-bradykinin greater than bradykinin-(1-5). This correlation suggested that G proteins are the targets of kinins in mast cells. Accordingly, the concomitant increase in inositol trisphosphates and release of histamine elicited by kinins were inhibited by pertussis toxin pretreatment of mast cells. The inhibitory effect of benzalkonium chloride showed that the G proteins involved belong to the Gi type. GTPase activity was measured in the supernatant of homogenized mast cells but not in the membranous fraction. This activity was stimulated by kinins and by the venom peptide mastoparan. The potency of peptides was similar to that observed with purified bovine G proteins. Sodium dodecyl sulfate-gel electrophoresis of mast cell supernatant revealed pertussis toxin-induced ADP-ribosylation of two proteins, in the Mr 41,000 and 40,000 range, i.e., similar to purified alpha-subunits of Gi1 and Gi2 or Gi3 subtypes. The data support the proposal that bradykinin and analogues act like mastoparan, substance P, and compound 48/80, interacting first with sialic acid residues of the cell surface and then with Gi-like proteins, inducing phospholipase C activation and intracellular calcium mobilization. [less ▲]

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See detailBinding characteristics of [125I]endothelin-1 in guinea-pig trachea and its displacement by endothelin-1, endothelin-3 and endothelin (16-21)
Tschirhart, Eric UL; Pelton, J. T.; Jones, C. R.

in Agents and Actions. Supplements (1991), 31

The presence of binding sites for endothelin-1 (ET-1) and endothelin-3 (ET-3) in airway epithelium, submucosa and smooth muscle of guinea-pig trachea was investigated using in vitro autoradiography. We ... [more ▼]

The presence of binding sites for endothelin-1 (ET-1) and endothelin-3 (ET-3) in airway epithelium, submucosa and smooth muscle of guinea-pig trachea was investigated using in vitro autoradiography. We also examined the ability of the C-terminal hexapeptide of endothelin, ET(16-21) to inhibit specific [125I]ET-1, binding. ET-1 appeared to bind to a single class of binding sites (nH not different from unity). In contrast, nH values for ET-3 displacement of [125I]ET-1 specific binding were different from unity, suggesting that these peptides bound to more than one site. ET (16-21) did not affect [125I]ET-1 binding. The present results suggest that the binding sites identified in guinea pig airway smooth muscle may be related to receptors mediating contractile responses to the endothelins. [less ▲]

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See detailInhibition of endothelin-1 induced myocardial protein synthesis by an antisense oligonucleotide against the early growth response gene-1.
Neyses, Ludwig UL; Nouskas, J.; Vetter, H.

in Biochemical and biophysical research communications (1991), 181(1), 22-7

We explored the role of the recently discovered "early growth response gene-1 (Egr-1)" in the induction of myocardial protein synthesis by endothelin-1. Endothelin-1 stimulated protein synthesis (i.e. 3H ... [more ▼]

We explored the role of the recently discovered "early growth response gene-1 (Egr-1)" in the induction of myocardial protein synthesis by endothelin-1. Endothelin-1 stimulated protein synthesis (i.e. 3H-phenylalanine incorporation) in isolated adult rat cardiomyocytes more than 2-fold. Addition of a 15mer Egr-1 antisense oligodeoxyribonucleotide complementary to the first 5 codons of the Egr-1 mRNA completely blocked endothelin-induced protein synthesis. A single base mismatch in the oligonucleotide sequence abolished the inhibitory effect. T3-induced stimulation of protein synthesis was unaffected by the antisense oligonucleotide. These results indicate that the Egr-1 gene product is involved (putatively as a third messenger) in the signal transduction cascade initiated by endothelin-1 which eventually culminates in the induction of cardiac protein synthesis. [less ▲]

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See detailPerformance Analysis of the Total Least Squares ESPRIT Algorithm
Ottersten, Björn UL; Viberg, M.; Kailath, T.

in IEEE Transactions on Signal Processing (1991), SP-39

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See detailBarrier Height Enhancement of n-In0.53Ga0.47As Schottky Diodes Grown by MOCVD Technique
Kordoš, P.; Marso, Michel UL; Meyer, R. et al

in Electronics Letters (1991), 27(1991), 1759-1760

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See detailLa propriété de Wiener
Molitor-Braun, Carine UL

in Travaux Mathématiques (1991), 3

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See detailgl(∞) and geometric quantization
Bordemann, Martin UL; Hoppe, Jens; Schaller, Peter et al

in Communications in Mathematical Physics (1991), 138(2), 209-244

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See detailControlled noxious chemical stimuation: reponses of rat trigeminal brainstem neurons to CO2 pulses applied to the naal mucosa
Anton, Fernand UL; Peppel, Petra; Euchner, Ingrid et al

in Neuroscience Letters (1991), 123(2), 208-211

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See detailMortalité par accident dans les mines de charbon en Belgique aux XIXe-XXe siècles
Leboutte, René UL

in Revue du Nord (1991), LXXIII, 293

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See detailAnalysen der Bedeutungsstrukturen alltagssprachlicher Emotionswörter: Grundzüge eines Verfahrens, exemplarische Anwendung, Implikationen für die Forschung zu spezifischen Emotionen
Neppl, Rainer; Boll, Thomas UL

in Sprache und Kognition (1991), 10(2), 85-96

The paper presents a procedure that uses speech analysis to assess the meaning structures in natural-language emotion terms. It is noted that most psychological research on specific emotions is based on a ... [more ▼]

The paper presents a procedure that uses speech analysis to assess the meaning structures in natural-language emotion terms. It is noted that most psychological research on specific emotions is based on a structuring of the emotion domain provided by natural-language emotion terms, and that the vagueness and inconsistencies of natural-language emotion terms is frequently problematic. The proposed procedure assumes that the use of natural-language emotion terms in the attribution of emotions to self and others is guided by rules, that these rules can be reconstructed, and that the outcome of this reconstruction can be described as an (abstract) structure. The general procedure for obtaining these structures (explicit meaning structures) is described and illustrated with the German emotion term "Empoerung" (moral indignation). Then possible applications of the procedure and the explicit meaning structures are discussed: explicit meaning structures as (1) a reference point for intercultural emotion research, (2) as a starting point for differentiating empirical and pseudo-empirical questions, (3) for defining and operationalizing the object of research, and (4) for generating hypotheses on conditions, consequences, and possibilities of modifying specific emotions. [less ▲]

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See detailZur inhaltlichen Bestimmung und Erfassung von Lebensqualität um Umfeld schwerer körperlicher Erkrankungen.
Filipp, Sigrun-Heide; Ferring, Dieter UL

in Praxis der Klinischen Verhaltensmedizin und Rehabilitation (1991)

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See detailValidity of the interaction model of anger: Studies in management and competitive sport
Steffgen, Georges UL; Schwenkmezger, Peter

in German Journal of Psychology (1991)

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See detailJugend zwischen Märkten und Verbänden
Willems, Helmut UL; Eckert, Roland; Drieseberg, Drieseberg

in Deutsche Jugend: Zeitschrift für die Jugendarbeit (1991), (10), 435-442

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See detailG-proteins as targets for non-immunological histamine releasers
Mousli, M.; Bueb, Jean-Luc UL; Rouot, B. et al

in Agents and Actions (1991), 33(1-2), 81-3

The molecular mechanism of action of several non-immunological histamine releasers has been investigated using pertussis toxin which interfers, via ADP-ribosylation, with some G-proteins. Pertussis toxin ... [more ▼]

The molecular mechanism of action of several non-immunological histamine releasers has been investigated using pertussis toxin which interfers, via ADP-ribosylation, with some G-proteins. Pertussis toxin (100 ng/ml) inhibited histamine release induced by compound 48/80, substance P, mastoparan, peptide 401, bradykinin and spermine showing that a G-protein sensitive to pertussis toxin was involved in the non-immunological histamine release. All these compounds directly activate purified G-proteins. The sensitivity to pertussis toxin of this direct stimulatory effect was demonstrated for compound 48/80, mastoparan and substance P. Altogether these results suggest that a direct activation of G-protein might be the molecular mechanism of action of histamine secretagogues acting through a pertussis toxin sensitive G-protein and in this way mimic agonist-ligand receptor interaction. [less ▲]

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See detailCentral projections of trigeminal primary afferents innervating the nasal mucosa: a horseradish peroxidase study in the rat
Anton, Fernand UL; Peppel, Petra

in Neuroscience (1991), 41(2-3), 617-628

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See detailKalium-Restriktion und essentielle Hypertonie
Neyses, Ludwig UL

in Deutsche Medizinische Wochenschrift (1946) (1991), (116), 2417-2248

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See detailEvidence for the interaction of mast cell-degranulating peptide with pertussis toxin-sensitive G proteins in mast cells
Mousli, M.; Bronner, C.; Bueb, Jean-Luc UL et al

in European Journal of Pharmacology (1991), 207(3), 249-55

K(+)-channel blocker properties have been reported for mast cell-degranulating peptide (MCD) in the central nervous system, but its action mechanism in mast cells remains unknown. We studied the effect of ... [more ▼]

K(+)-channel blocker properties have been reported for mast cell-degranulating peptide (MCD) in the central nervous system, but its action mechanism in mast cells remains unknown. We studied the effect of MCD on the membrane potential of rat peritoneal mast cells using the fluorescent probe bis-oxonol. Unexpectedly, MCD induced a decrease in bis-oxonol fluorescence, in a rapid and then a slower phase, suggesting hyperpolarization of mast cells. Other K(+)-channel blockers, tetraethylammonium and 4-aminopyridine, did not significantly modify the bis-oxonol fluorescence and did not alter the effect of MCD. The late phase of bis-oxonol fluorescence decrease was inhibited by ouabain and by potassium deprivation, whereas histamine release was not affected. The first phase of putative hyperpolarization induced by MCD coincided with histamine release and with the generation of inositol polyphosphates. Prior treatment of the cells with pertussis toxin inhibited these effects of MCD. MCD stimulated the GTPase activity of purified G proteins (G0/Gi) in a concentration-dependent manner. These results indicate that the effect of MCD on mast cells is unrelated to K+ channels but that it is relevant to the activation of pertussis toxin-sensitive G proteins leading to the activation of phospholipase C. A direct interaction of MCD with G proteins is proposed, which, unlike mastoparan, does not require positive cooperativity. [less ▲]

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See detailMethodisch handelen. Over de betekenis voor de radiologische beroepspraktijk.
Biesta, Gert UL

in Gamma. (1991), 41(2), 42-49

Detailed reference viewed: 92 (2 UL)
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See detailMolecular basis for cellular effects of naturally occurring polyamines
Bueb, Jean-Luc UL; Mousli, M.; Landry, Y.

in Agents and Actions (1991), 33(1-2), 84-7

The naturally occurring polyamines, putrescine, spermidine and spermine, and the analogue cadaverine, induce a dose-dependent histamine release from rat peritoneal mast cells. Spermine was the most active ... [more ▼]

The naturally occurring polyamines, putrescine, spermidine and spermine, and the analogue cadaverine, induce a dose-dependent histamine release from rat peritoneal mast cells. Spermine was the most active among these polycationic metabolites, followed by spermidine and putrescine. The histamine release was inhibited by a 2 h pretreatment of the cells with pertussis toxin (100 ng/ml), demonstrating the involvement of a pertussis toxin-sensitive GTP-binding regulatory protein during the exocytotic process. Experiments performed with purified Go/Gi proteins reconstituted into phospholipid vesicles showed a direct stimulation of GTPase activity by the polyamines. This direct stimulation of G proteins and the consequent activation of the coupled effectors may represent a new mechanism of action for natural polyamines controlling receptor-dependent processes. [less ▲]

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See detailStress e disturbi cardiovasculari. Problemi metodologici nell'utilizo della tecnica dello stress mentale (Mental Stress Test)
Pruneti, Carlo A.; Vögele, Claus UL; Steptoe, Andrew

in Medicina Psicosomatica (1991), 36

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See detailGaInAs Camel transistors With Current Gain Above 6 at Room Temperature
Marso, Michel UL; Zwinge, G.; Grützmacher, D. et al

in Electronics Letters (1991), 27(1991), 335-337

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See detailModelle der dreimodalen Faktorenanalyse: formale Eigenschaften, theoretische Zusammenhänge und ihre Implikationen für das Konzept individueller Differenzen
Krolak-Schwerdt, Sabine UL

in Psychologische Beiträge (1991), 133

The present paper is concerned with methods of three-mode factor analysis to obtain a dimensional representation of three-way data. Classifying the methods by the number of derived spaces and their ... [more ▼]

The present paper is concerned with methods of three-mode factor analysis to obtain a dimensional representation of three-way data. Classifying the methods by the number of derived spaces and their interrelations yields two distinct classes of models: CANDECOMP (Carroll & Chang, 1970), PARAFAC (Harshman, 1976) and SUMMAX (Orlik, 1980) rest on a basic trilinear decornposition of the data defining a separate space for each mode, whereas Tucker's (1964a thrce-mode factor analysis and SUMMA X in its extended form use a quadeilinear model specifying an additional core matrix. Associated with the current classification are different properties of the two model classes which refer to the number of substantial dimensions, their interpretation and the orientation of dimensions which is subject to rotations within the quadrilinear dass and uniquely determined by trilinear methods. Considering the different characteristics of the methods, formal relations between the classes have been found under very restrictive conditions only. However, there exist some general connections between trilinear and quadrilinear models. CANDECOMP and PARAFAC derive from the trilinear SUMMAX model by rescaling and permutation of axes, and the methodological link between the Tucker model and SUMMAX is given by orthogonal rotations of the SUMMAX configuration. These relationships are shown in an empirical example and their implications for the distinct concepts of individual differences within the two classes of methods are discussed. [less ▲]

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See detailSome Results of Heterogeneous Data Inversions for Oceanic Tides
Jourdin, F.; Francis, Olivier UL; Vincent, P. et al

in Journal of Geophysical Research (1991), 96(B12), 20267-20288

Detailed reference viewed: 112 (9 UL)
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See detailAnspruch und Wirklichkeit. Theodor W. Adornos Beitrag zur 'Rettung' Stefan Georges
Heimböckel, Dieter UL

in Castrvm peregrini : Zeitschrift für Literatur, Kunst- und Geistesgeschichte (1991), CXCVI-CXCVII

Detailed reference viewed: 184 (1 UL)
See detailTheoretische Pedagogiek (De AERA Annual Meeting: Chicago 1991).
Miedema, S.; Biesta, Gert UL

in Pedagogische Studiën: Tijdschrift voor Onderwijskunde en Opvoedkunde (1991), 68

Detailed reference viewed: 53 (1 UL)
See detailSelective implication of thromboxane A2 and PAF-acether in two guinea pig anaphylactic models
Bertrand, C.; Tschirhart, Eric UL; Landry, Y.

in Agents and Actions. Supplements (1991), 31

In an IgE and an IgG model of anaphylaxis in the guinea pig, we investigated the role of prostanoids and PAF-acether in the tracheal response in vitro to immunochallenge. Indomethacin (10(-6) M ... [more ▼]

In an IgE and an IgG model of anaphylaxis in the guinea pig, we investigated the role of prostanoids and PAF-acether in the tracheal response in vitro to immunochallenge. Indomethacin (10(-6) M) potentiated the antigen-induced contraction in both models suggesting the synthesis of relaxant prostaglandins during the anaphylactic phenomenon. UK-38,485 (10(-5) M), a thromboxane (TxA2) synthetase inhibitor, did not modify the tracheal response in the IgE model. In the IgG model, this drug reduced the response of the tracheal strips to antigen. Ro 19-3704 (10(-6) M) and BN 52021 (10(-5) M), two potent PAF antagonists, reduced antigen-induced contraction of the tracheal strips in the IgE model. These two drugs did not modify the contractile response in the IgG model. These results indicate that PAF-acether and TxA2 play a role in the IgE and IgG model of anaphylaxis, respectively. [less ▲]

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See detailThe methodology of mental stress testing in cardiovascular research.
Steptoe, Andrew; Vögele, Claus UL

in Circulation (1991), 83(Suppl II), 14-24

Many issues related to the selection, reliability, and validity of mental stress testing in cardiovascular research are discussed. Five categories of mental stress testing are distinguished: problem ... [more ▼]

Many issues related to the selection, reliability, and validity of mental stress testing in cardiovascular research are discussed. Five categories of mental stress testing are distinguished: problem-solving tasks, information-processing tasks, psychomotor tasks, affective conditions, and aversive or painful conditions. A series of practical and theoretical criteria are outlined for the selection of appropriate tests, and the measurement of a range of dependent variables is emphasized. The temporal stability of cardiovascular responses to mental stress tests is examined through an analysis of test-retest correlations (weighted for sample size) in 28 comparisons with intervals between sessions varying from 1 day to more than 1 year. Heart rate reactions to tasks show an average-weighted Z of 0.732 +/- 0.031 (r = 0.62), with Z = 0.575 +/- 0.034 (r = 0.52) for systolic blood pressure and Z = 0.313 +/- 0.035 (r = 0.30) for diastolic blood pressure. It is argued that the validity of mental stress tests can be judged in relation to several different aspects, specifically, methodological, ecological, diagnostic, prognostic, and therapeutic validities. The nature of these standards is described, and pertinent literature is presented. [less ▲]

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See detailc-Fos immunoreactivity in rat brainstem neurons following noxious chemical stimulation of the nasal mucosa
Anton, Fernand UL; Herdegen, Thomas; Peppel, Petra et al

in Neuroscience (1991), 41(2-3), 629-641

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See detailPax: a murine multigene family of paired box-containing genes.
Walther, C.; Guenet, J. L.; Simon, D. et al

in Genomics (1991), 11(2), 424-34

A murine multigene family has been identified that shares a conserved sequence motif, the paired box, with developmental control and tissue-specific genes of Drosophila. To date five murine paired box ... [more ▼]

A murine multigene family has been identified that shares a conserved sequence motif, the paired box, with developmental control and tissue-specific genes of Drosophila. To date five murine paired box-containing genes (Pax genes) have been described and one, Pax-1, has been associated with the developmental mutant phenotype undulated. Here we describe the paired boxes of three novel Pax genes, Pax-4, Pax-5, and Pax-6. Comparison of the eight murine paired domains of the mouse, the five Drosophila paired domains, and the three human paired domains shows that they fall into six distinct classes: class I comprises Pox meso, Pax-1, and HuP48; class II paired, gooseberry-proximal, gooseberry-distal, Pax-3, Pax-7, HuP1, and HuP2; class III Pax-2, Pax-5, and Pax-8; class IV Pax-4; class V Pox neuro; and class VI Pax-6. Pax-1 and the human gene HuP48 have identical paired domains, as do Pax-3 and HuP2 as well as Pax-7 and HuP1, and are likely to represent homologous genes in mouse and man. Identical intron-exon structure and extensive sequence homology of their paired boxes suggest that several Pax genes represent paralogs. The chromosomal location of all novel Pax genes and of Pax-3 and Pax-7 has been determined and reveals that they are not clustered. [less ▲]

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See detailStructure, expression and chromosomal location of the Oct-4 gene.
Yeom, Y. I.; Ha, H. S.; Balling, Rudi UL et al

in Mechanisms of Development (1991), 35(3), 171-9

The map position of Oct-4 on mouse chromosome 17 is between Q and T regions in the Major Histocompatibility Complex (MHC), and it is physically located within 35 kb of a class I gene. Several Oct-4 ... [more ▼]

The map position of Oct-4 on mouse chromosome 17 is between Q and T regions in the Major Histocompatibility Complex (MHC), and it is physically located within 35 kb of a class I gene. Several Oct-4-related genes are present in the murine genome; one of them maps to chromosome 9. The genomic structure and sequence of Oct-4 determined in t-haplotypes reveals five exons, and shows no significant changes in the t12 mutant haplotype making it unlikely that Oct-4 and the t12 early embryonic lethal are the same gene. By in situ hybridization, detectable onset of zygotic Oct-4 expression does not occur until compaction begins at 8-cells, suggesting that there might be other regulatory factors responsible for initiating Oct-4 expression. [less ▲]

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See detailÄrger lass nach - Ärger auf der Trainerbank
Steffgen, Georges UL

in Sportpsychologie (1991), 5(3), 14-17

Nicht nur Fußballspieler, sondern auch Trainer sind während eines Spiels emotional belastet. Im Leistungssport werden jedoch psychoregulative Fertigkeiten bisher meist nur von Sportlern gefordert. Im ... [more ▼]

Nicht nur Fußballspieler, sondern auch Trainer sind während eines Spiels emotional belastet. Im Leistungssport werden jedoch psychoregulative Fertigkeiten bisher meist nur von Sportlern gefordert. Im folgenden wird aus sportpsychologischer Sicht das Problem von Trainern mit Ärgersituationen umrissen und auf angemessene Umgangsweisen eingegangen. [less ▲]

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See detailSubstance P and calcitonin gene-related peptide immunoreactivity in primary afferent neurons of the cat`s knee joint
Hanesch, Ulrike UL; Heppelmann, Bernd; Schmidt, Robert

in Neuroscience (1991), 45

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See detailDetection and Estimation in Sensor Arrays Using Weighted Subspace Fitting
Viberg, M.; Ottersten, Björn UL; Kailath, T.

in IEEE Transactions on Signal Processing (1991), SP-39(11), 24362449

Detailed reference viewed: 36 (0 UL)
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See detailSensor Array Processing Based on Subspace Fitting
Viberg, M.; Ottersten, Björn UL

in IEEE Transactions on Signal Processing (1991), SP-39(5), 11101121

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See detailUtilisation de médicaments anti-diabétiques au Grand Duché de Luxembourg
De Beaufort, Carine UL; Michel, G.; Haas, N. et al

in Bulletin de la Société des Sciences Médicales du Grand-Duché de Luxembourg (1991), 2

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See detailIncidence du diabète insulino-dépendant, survenant avant l’âge de 20 ans en France
Levy-Marchal, C.; Pappoz, L.; De Beaufort, Carine UL et al

in Pediatrie (1991), 46

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See detailM2 World Ocean Tide from Tide Gauge Measurements
Francis, Olivier UL; Mazzega, P.

in Geophysical Research Letters (1991), 18(6), 1167-1170

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See detailCRABP and the teratogenic effects of retinoids
Balling, Rudi UL

in Trends in Genetics (1991), (7), 279-287

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See detailPrévalence du diabète insulino-dépendant chez les enfants scolarisés de 6 a 16 ans en Lorraine
De Beaufort, Carine UL; Cecchi-Tenerini, R.; Clerc, R. et al

in Archives Françaises de Pédiatrie (1991), 48

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See detailWetenschapspedagogiek. Over de pedagogische bijdrage aan het wetenschapstheoretisch debat.
Biesta, Gert UL; Miedema, S.

in Comenius (1991), 11(1), 20-36

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See detailEndothelins: functional and autoradiographic studies in guinea pig trachea
Tschirhart, Eric UL; Drijfhout, J. W.; Pelton, J. T. et al

in Journal of Pharmacology and Experimental Therapeutics (1991), 258(1), 381-7

The presence of binding sites for [125I]endothelin-1 and the contractile activities of endothelins (ETs) and sarafotoxin S6b and the endothelin fragment ET(16-21) were investigated in guinea pig trachea ... [more ▼]

The presence of binding sites for [125I]endothelin-1 and the contractile activities of endothelins (ETs) and sarafotoxin S6b and the endothelin fragment ET(16-21) were investigated in guinea pig trachea. ETs and sarafotoxin S6b (0.1-100 nM) induced potent contractile responses in guinea pig trachea with EC50 values ranging from 1.57 to 12.97 nM. Epithelium removal increased the potencies of ET-1, ET-2 and S6b, but not that of ET-3, and maximal responses to ET-1 and ET-2 were also increased. Effects of epithelium removal were partially mimicked by phosphoramidon (10 microM), an enkephalinase inhibitor, suggesting that enkephalinase (EC.3.4.24.11.) is able to degrade ET-1 and ET-2. ET-3-induced contractions were not affected by phosphoramidon. Autoradiographic studies suggested the presence of at least two specific binding sites for [125]ET-1 in guinea pig airway smooth muscle. The correlation between Kd and EC50 values suggests that the binding sites identified in the airway smooth muscle represent functional receptors for ETs. ET(16-21) and ET(16-21)-NH2 were less potent agonists than the ETs in guinea pig trachea and 10 microM ET(16-21) was unable to inhibit [125I]ET-1 binding in guinea pig airway smooth muscle. Therefore, these results suggest that the C-terminal hexapeptide of ET-1 cannot be used to classify ET receptors in guinea pig trachea. [less ▲]

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See detailLes instruments de paiement et de crédit (1980-1989)
Dal, Georges-Albert; Corbisier, Isabelle UL

in Journal des Tribunaux (1990), (5554), 429-442

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See detailPouvoir et transparence dans la relation thérapeutique
Corbisier, Isabelle UL

in Revue Générale des Assurances et des Responsabilités [=RGAR] (1990), (11682), 19

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See detail[Disturbed endothelium-dependent blood vessel relaxation in essential hypertension].
Neyses, Ludwig UL; Vetter, H.

in Deutsche medizinische Wochenschrift (1946) (1990), 115(51-52), 1981

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See detailThe Fourth International Workshop on the Standardisation of Insulin Autoantibody Measurement
Kolb, H.; Arnaiz-Villena, A.; De Beaufort, Carine UL et al

in Diabetologia (1990), 33(10), 638-639

[No abstract available]

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See detailPsychological impact of continuous subcutaneous insulin infusion pump therapy in non-selected newly diagnosed insulin dependent (type 1) diabetic children: Evaluation after two years of therapy [IMPACT PSYCHOLOGIQUE D'UN TRAITEMENT PAR PERFUSION SOUS-CUTANEE CONTINUE D'INSULINE DES LE DIAGNOSTIC CHEZ LES ENFANTS DIABETIQUES NON SELECTIONNES: EVALUATIONS APRES DEUX AND DE TRAITEMENT]
Slijper, F.M.E.; De Beaufort, Carine UL; Bruining, G.J. et al

in Diabete et Metabolisme (1990), 16(4), 273-277

Thirty type 1 (insulin dependent) diabetic children were treated from diagnosis onwards in a random order (using a table of random permutations) with either continous subcutaneous insulin infusion pump ... [more ▼]

Thirty type 1 (insulin dependent) diabetic children were treated from diagnosis onwards in a random order (using a table of random permutations) with either continous subcutaneous insulin infusion pump therapy (CSII), or with conventional injection therapy (CT). After two years of therapy psychosocial measurements were obtained of fifteen CSII children (8 boys, 7 girls; mean age: 12+/-4 years) and thirteen CT children (6 boys, 7 girls; mean age: 10+/-4 years) and their parents. Two families of the CT group refused to participate. The examination consisted of six tests (for the children: junior dutch personality test, WISC-R intelligence test, family relation test, diabetes questionnaire; for the parents: family interaction scale and assessment of acceptance scale). Parents (and pediatricians) rated CSII children higher on compliance and better on metabolic control. Acceptance of diabetes, physical and psychological condition was rated equally by parents and doctors. Except for the diabetes questionnaire, the children of the two groups scored not significantly different. The CSII group expressed significantly less physical complaints and physical restrictions. CSII children showed a tendency to score higher on recalcitrance compared with CT children. How adequate this coping of CSII children may be, is discussed. [less ▲]

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See detailOverexpression of a Streptomyces viridochromogenes gene (glnII) encoding a glutamine synthetase similar to those of eucaryotes confers resistance against the antibiotic phosphinothricyl-alanyl-alanine
Behrmann, Iris UL; Hillemann, D.; Pühler, A. et al

in Journal of Bacteriology (1990), 172(9), 5326-34

Phosphinothricyl-alanyl-alanine (PTT), also known as bialaphos, contains phosphinothricin, a potent inhibitor of glutamine synthetase (GS). A 2.75-kilobase NcoI fragment of the Streptomyces ... [more ▼]

Phosphinothricyl-alanyl-alanine (PTT), also known as bialaphos, contains phosphinothricin, a potent inhibitor of glutamine synthetase (GS). A 2.75-kilobase NcoI fragment of the Streptomyces viridochromogenes PTT-resistant mutant ES2 cloned on a multicopy vector mediated PTT resistance to S. lividans and to S. viridochromogenes. Nucleotide sequence analysis of the 2.75-kb NcoI fragment revealed the presence of three open reading frames. Open reading frame 3 was termed glnII since significant similarity was found between its deduced amino acid sequence and those from GS of eucaryotes and GSII of members of the family Rhizobiaceae. Subcloning experiments showed that PTT resistance is mediated by overexpression of glnII encoding a 37.3-kilodalton protein of 343 amino acids. A three- to fourfold increase in gamma-glutamyltransferase activity could be observed in S. lividans transformants carrying the glnII gene on a multicopy plasmid. For S. viridochromogenes it was shown that PTT resistance conferred by the 2.75-kb NcoI fragment was dependent on its multicopy state. GS activity encoded by glnII was found to be heat labile. Southern hybridization with seven different Streptomyces strains suggested that they all carry two types of GS genes, glnA and glnII. [less ▲]

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See detailLes groupes exponentiels. Deuxième partie
Molitor-Braun, Carine UL

in Travaux Mathématiques (1990), 2

Detailed reference viewed: 37 (3 UL)
See detailPsychometrische Modelle zur Bestimmung von Konsistenz und Spezifität im Bewältigungsverhalten.
Ferring, Dieter UL; Klauer, Thomas; Filipp, Sigrun-Heide et al

in Zeitschrift für Differentielle und Diagnostische Psychologie (1990), 11(1)

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See detailIncidence of juvenile type 1 (insulin dependent) diabetes mellitus in France
Levy-Marchal, C.; Papoz, L.; De Beaufort, Carine UL et al

in Diabetologia (1990), 33

Detailed reference viewed: 88 (0 UL)
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See detailThe behaviour of the PSI (palmar sweat index) during two stressful laboratory situations.
Köhler, Thomas; Weber, Dittmar; Vögele, Claus UL

in Journal of Psychophysiology (1990), (4), 281-287

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See detailLa demande de proroger ou de payer une garantie autonome, observation sur l'arrêt de la chambre commerciale de la Cour de cassation, du 24 janvier 1989
Prüm, André UL; Mattout, Jean-Pierre

in La Semaine Juridique - Entreprise et Affaires (1990), II

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See detailFrom the structure to the function of villin, an actin-binding protein of the brush border.
Friederich, Evelyne UL; Pringault, E.; Arpin, M. et al

in BioEssays (1990), 12(9), 403-8

Villin, a calcium-regulated actin-binding protein, modulates the structure and assembly of actin filaments in vitro. It is organized into three domains, the first two of which are homologous. Villin is ... [more ▼]

Villin, a calcium-regulated actin-binding protein, modulates the structure and assembly of actin filaments in vitro. It is organized into three domains, the first two of which are homologous. Villin is mainly produced in epithelial cells that develop a brush border and which are responsible for nutrient uptake. Expression of the villin structural gene is precisely regulated during mouse embryogenesis and is restricted in adults, to certain epithelia of the gastrointestinal and urogenital tracts. The function of villin has been assessed by transfecting CV1 cells with a human cDNA encoding wild-type villin or mutant villin. Synthesis of large amounts of villin in cells which do not normally produce this protein induces the growth of microvilli on the cell surface and the redistribution of F-actin, concomitant with the disappearance of stress fibers. The complete villin sequence is required for the morphogenic effect. These results suggest that villin plays a key role in the morphogenesis of microvilli. [less ▲]

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See detailLogo, List Processing and Language Teaching
Weber, Jean-Jacques UL

in Bulletin Nouvelles Technologies et Education (1990), 5

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See detailLa filiation
Ravarani, Georges UL

in Feuille de liaison de la Conférence Saint-Yves n° 75 (1990)

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See detailKrichever-Novikov algebras for more than two points
Schlichenmaier, Martin UL

in Letters in Mathematical Physics (1990), 19(2), 151--165

Detailed reference viewed: 144 (2 UL)
See detailOntwikkelingen in het Amerikaanse theoretisch-pedagogishe debat.
Biesta, Gert UL; Miedema, S.

in Pedagogische Studiën: Tijdschrift voor Onderwijskunde en Opvoedkunde (1990), 67

Detailed reference viewed: 49 (1 UL)
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See detailEvidence for the involvement of calcitonin gene-related peptide in the epithelium-dependent contraction of guinea-pig trachea in response to capsaicin
Tschirhart, Eric UL; Bertrand, C.; Theodorsson, E. et al

in Naunyn-Schmiedeberg's Archives of Pharmacology (1990), 342(2), 177-81

Capsaicin (10(-9) to 10(-5) M) contracted guinea-pig tracheal strips. Epithelium-containing tracheal strips developed a maximum active tension which was significantly higher than that observed in ... [more ▼]

Capsaicin (10(-9) to 10(-5) M) contracted guinea-pig tracheal strips. Epithelium-containing tracheal strips developed a maximum active tension which was significantly higher than that observed in epithelium-free strips. Anti-CGRP (calcitonin gene-related peptide) serum blocked the epithelium-dependent potentiation of the capsaicin-induced contraction in the intact tracheal strips, without affecting the response of the epithelium-free strips. This result suggests the occurrence of an epithelium-dependent release of CGRP. This same serum markedly reduced the contraction induced by exogenous rat CGRP in both intact and epithelium-free tracheal strips. In epithelium-free tracheal strips, capsaicin-induced contraction was abolished by spantide (10(-6) and 10(-5) M), a substance P antagonist, but, in intact tracheal strips, spantide did not abolish the capsaicin-induced contraction, showing that both CGRP and substance P release are directly induced by capsaicin. Moreover, the contractile responses to rat CGRP of intact tracheal strips from guinea pig suggest that CGRP itself might be able to release a contracting factor from the airway epithelium. Therefore, CGRP originating from the airway epithelium may play a major role in the control of airway smooth muscle tone. [less ▲]

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See detailEinige Überlegungen zum Volkslied in Luxemburg
Sagrillo, Damien UL

in Eintracht im Thale. 125e Anniversaire 1865-1990 (1990)

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See detailThe role of homeobox genes in mammalian development
Kessel, M; Balling, Rudi UL; Gruss, P

in Developmental Endocrinology (1990)

Detailed reference viewed: 54 (0 UL)
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See detail[Hypertensive heart disease. Pathophysiological foundation, diagnosis and therapy].
Neyses, Ludwig UL; Vetter, H.

in Deutsche medizinische Wochenschrift (1946) (1990), 115(39), 1480-6

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See detailIsolated myocardial cells: a new tool for the investigation of hypertensive heart disease.
Neyses, Ludwig UL; Vetter, H.

in Journal of Hypertension. Supplement) (1990), 8(4), 99-102

Cardiac hypertrophy is characterized by marked abnormalities in the contraction/relaxation pattern of the heart. For example, delayed relaxation is a prominent feature, impairing ventricular filling and ... [more ▼]

Cardiac hypertrophy is characterized by marked abnormalities in the contraction/relaxation pattern of the heart. For example, delayed relaxation is a prominent feature, impairing ventricular filling and coronary flow. In intact heart preparations the relative contribution of fibrosis and of the myocardial cell itself to these abnormalities cannot be correctly assessed. Biochemical studies on the mechanisms of impaired contraction and relaxation and hypertensive heart failure are hampered by the fact that 75% of all heart cells are non-myocytes. We therefore established the model of the isolated calcium-tolerant, adult rat cardiomyocyte as a new approach to the investigation of these problems. Contractility was measured using a videomicroscope system with high time resolution (1 ms). Angiotensin II induced a marked relaxation delay in the cardiomyocyte from normotensive rats and showed a moderate positive inotropic effect, whereas isoproterenol had a strong positive inotropic effect but accelerated relaxation. Therefore, angiotensin II is capable of inducing a relaxation delay even in the absence of coronary ischaemia or hypertension. These first results show that the isolated cardiomyocyte model may be a useful approach to investigating the mechanisms of hypertensive heart disease. [less ▲]

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See detailOct-4: a germline-specific transcription factor mapping to the mouse t-complex
Schöler, H. R.; Dressler, G. R.; Balling, Rudi UL et al

in EMBO journal (1990), (9), 2185-2195

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See detailPosition-specific activity of the Hox1.1 promoter in transgenic mice.
Puschel, A. W.; Balling, Rudi UL; Gruss, P.

in Development (1990), 108(3), 435-42

During development, positional values have to be assigned to groups of cells. The murine Hox genes are a class of genes that are predicted to be involved at some stage in this process. During ... [more ▼]

During development, positional values have to be assigned to groups of cells. The murine Hox genes are a class of genes that are predicted to be involved at some stage in this process. During embryogenesis they are expressed in distinct overlapping region- and stage-specific patterns and therefore must be regulated in response to positional information. In this study, we have analysed the activity of Hox1.1 promoter sequences in transgenic mice. The use of lacZ as a marker allows a detailed analysis of expression at the single cell level during early embryonic development. We show that 3.6 kbp of promoter and 1.7 kbp of 3' sequences provide sufficient regulatory information to express a transgene in a spatial and temporal manner indistinguishable from the endogenous Hox1.1 gene during the period of development when Hox1.1 expression is established. The activation occurs in a strict order in specific ectodermal and mesodermal domains. Within each of these domains the transgene is activated over a period of four hours apparently randomly in single cells. In a following second period, Hox1.1 and transgene expression patterns diverge. In this period, transgene expression persists in many mesodermally derived cells that do not express Hox1.1 indicating the absence of a negative regulatory element in the transgene. The anterior boundary of transgene expression is identical to that of Hox1.1. However, no posterior boundary of transgene expression is set, suggesting that a separate element absent from the transgene specifies this boundary. [less ▲]

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See detailNeuropeptides and inflammation: presumed mechanisms in neurogenic inflammation
Landry, Y.; Bloch, J. G.; Mousli, M. et al

in Pathologie et Biologie (1990), 38(1), 53-6

Neuropeptides, among which substance P, VIP (Vasoactive intestinal peptide), somatostatin, neurotensin, dynorphin and enkephalins, are able to modulate inflammatory processes. Increasing interest is now ... [more ▼]

Neuropeptides, among which substance P, VIP (Vasoactive intestinal peptide), somatostatin, neurotensin, dynorphin and enkephalins, are able to modulate inflammatory processes. Increasing interest is now devoted to these peptides in different inflammatory diseases, concerning skin, lung and joins. The effect of substance P can be dependent on its C-terminal moiety implicating by this way an interaction with specific neurokinin receptors or can be dependent on its N-terminal moiety which does not involve a specific membrane receptor. Such diversity of the action mechanisms of peptides should influence the evolution of the anti-inflammatory therapeutic. [less ▲]

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See detailZur Gültigkeit des interaktionistischen Ärgermodells: Untersuchungen im Management und Leistungssport
Steffgen, Georges UL; Schwenkmezger, Peter

in Zeitschrift für Experimentelle und Angewandte Psychologie (1990), 37(4), 623-641

Im Mittelpunkt dieser Untersuchung steht die Überprüfung des interaktionistischen Ansatzes, der den Ärgermodellen von Novaco (1978) und Spielberger (1988) zugrunde liegt. Anhand zweier Stichproben, einer ... [more ▼]

Im Mittelpunkt dieser Untersuchung steht die Überprüfung des interaktionistischen Ansatzes, der den Ärgermodellen von Novaco (1978) und Spielberger (1988) zugrunde liegt. Anhand zweier Stichproben, einer Manager- und einer Leistungssportlerstichprobe (N =97 bzw. N =74), sollen zudem unterschiedliche ärgerauslösende Situationsklassen und Ärgerdimensionen aufgezeigt werden. Als Ergebnisse sind festzuhalten: Eine Ärgerreaktion läßt sich in eine physiologische, eine kognitive und zwei verhaltensmäßige Komponenten differenzieren. Bezüglich der letzteren wird die Dimensionierung des Ärgerausdrucks in zwei unterschiedliche Komponenten, Anger out und Anger in, bestätigt. Die Bereichsspezifität der Ärgerneigung konnte durch eine Dimensionierung von Ärgersituationen nur in eingeschränktem Maße nachgewiesen werden. Die Ergebnisse zur Gültigkeit des unteraktionistischen Ansatzes differenzieren zwischen der gewählten Auswertungsmethoden. Lassen sich die prozentualen Varianzanteile bei den Stichproben in Richtung eines unteraktionistischen Modells auslegen, so sind die Generalisierbarkeitskoeffizienzen zumindest bei einer Stichprobe nicht in dieser Eindeutigkeit zu interpretieren. [less ▲]

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See detailTumorigenesis and eye abnormalities in transgenic mice expressing MSV-SV40 large T-antigen.
Theuring, F.; Gotz, W.; Balling, Rudi UL et al

in Oncogene (1990), 5(2), 225-32

Transgenic mice which expressed SV40 large T-antigen under the control of the MSV enhancer and the SV40 promoter were generated. In animals containing an intact MSV enhancer, total lens cataracts and ... [more ▼]

Transgenic mice which expressed SV40 large T-antigen under the control of the MSV enhancer and the SV40 promoter were generated. In animals containing an intact MSV enhancer, total lens cataracts and neuroectodermal brain tumors, originating in the pineal organ were observed. In contrast, 5' deletion of the MSV enhancer to a residual 53 bp resulted in a different spectrum of pathologies. Whilst lens cataracts still occurred, no brain tumors could be detected. Instead, fibrosarcomas and adenocarcinomas of the kidneys were induced. In addition, tumors of the endocrine pancreas were observed with both transgene constructs. We conclude that the MSV enhancer element is sufficient to direct the expression of the viral reporter gene to the lens and the pineal organ in transgenic mice. Deletion of the MSV enhancer correlates with the loss of DNA elements responsible for the pineal cell specific expression of SV40 large T-antigen. [less ▲]

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See detailResponses of nociceptive SI neurons in monkeys and pain sensation in humans elicited by noxious thermal stimulation: effect of interstimulus interval
Chudler, Eric H; Anton, Fernand UL; Dubner, Ronald et al

in Journal of Neurophysiology (1990), 63(3), 559-569

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