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See detailInstrumental Variable Approach to Array Processing in Spatially Correlated Noise Fields
Stoica, Petre; Viberg, Mats; Ottersten, Björn UL

in IEEE Transactions on Signal Processing (1994)

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See detailToeplitz quantization of Kähler manifolds and gl(N), N to infinity, limits
Bordemann, Martin UL; Meinrenken, Eckhard; Schlichenmaier, Martin UL

in Communications in Mathematical Physics (1994), 165

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See detailErnst Martin: Johann Kettiger und Johann Heinrich Pestalozzi. Zur Wirkungsgeschichte Pestalozzis
Tröhler, Daniel UL

in Paedagogica Historica (1994), XXX(2), 671-682

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See detailTesticular self-examination: Attitudes and practices among young men in Europe
Wardle, Jane; Steptoe, Andrew; Burckhardt, Ruth et al

in Preventive Medicine (1994), 23

BACKGROUND: Testicular self examination (TSE) is recommended for the early detection of testicular cancer. Evidence from North America suggests there is only limited public awareness of its importance ... [more ▼]

BACKGROUND: Testicular self examination (TSE) is recommended for the early detection of testicular cancer. Evidence from North America suggests there is only limited public awareness of its importance among the young male population. Compliance with regular TSE is found in only a small minority of young men. Attitudes toward and practice of TSE have rarely been studied outside North America. METHOD: Attitudes to TSE were evaluated by questionnaire in a sample of 16,486 students. Frequency of TSE practice was reported by the 7,304 men in the sample. The data were collected as part of the European Health Behavior Survey, an international study on health beliefs and health behavior. RESULTS: Eighty-seven percent of men reported never having practiced TSE. Regular practice (monthly) was reported by only 3% of the sample, with another 10% reporting occasional TSE. Significant differences emerged between countries, ranging from 76% of German men to 98% of Icelandic men reporting no TSE. Men rated TSE as less important to health than women. Attitude toward TSE among men was a significant predictor of TSE practice. CONCLUSION: Both the low levels of TSE and the low ratings of the importance of TSE suggest that young men in Europe are unaware of the value of this comparatively simple method of early detection of cancer. If a highly educated population group in the "at risk" age category is not carrying out the recommendations, it is unlikely that there are higher levels of compliance in other groups. These results suggest an important role for health education in the early detection of testicular cancer. [less ▲]

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See detailMouse genetics and the development of vertebral column development
Balling, Rudi UL; Koseki, H; Wallin, J et al

in Proceedings Greenwood Genetics Center (1994), (13), 58-60

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See detailMitogenic signals control translation of the early growth response gene-1 in myogenic cells.
Maass, A.; Grohe, C.; Oberdorf, S. et al

in Biochemical and biophysical research communications (1994), 202(3), 1337-46

Muscle is a major site of expression of the early growth response gene-1 (Egr-1). To investigate its role in muscle proliferation and/or differentiation we studied the effect of a variety of growth ... [more ▼]

Muscle is a major site of expression of the early growth response gene-1 (Egr-1). To investigate its role in muscle proliferation and/or differentiation we studied the effect of a variety of growth factors on cultured mouse muscle Sol8 cells. Three groups of responses could be distinguished: 1. AII, endothelin, phenylephrine, and PMA induced Egr-1 mRNA accumulation, but the message remained untranslated. These factors induced neither differentiation nor proliferation. 2. Insulin induced differentiation. It stimulated Egr-1 mRNA accumulation, but no translation into the Egr-1 protein was seen. 3. bFGF, PDGF BB, and FCS strongly induced DNA- and protein synthesis (i.e. proliferation) and Egr-1 mRNA accumulation. Only under these conditions was the message translated into protein. We conclude: 1. AII, endothelin, phenylephrine, and PMA elicit a nuclear response in Sol8 muscle cells which may lead to reprogramming of genes unrelated to differentiation or proliferation. 2. Differentiation induces a translational block of the Egr-1 mRNA which is only relieved by mitotic stimuli. 3. These results strongly suggest a pivotal role of Egr-1 in muscle proliferation and define translational control as a new mechanism of Egr-1 regulation. [less ▲]

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See detailStructure-activity studies of bradykinin analogues on rat mast cell histamine release
Bueb, Jean-Luc UL; Mousli, M.; Landry, Y. et al

in Peptides (1993), 14(4), 685-9

Bradykinin (BK), kallidin (KD), and various analogues induced histamine release from rat mast cells. The results obtained with substituted analogues of BK indicated that: 1) the presence of both Arg ... [more ▼]

Bradykinin (BK), kallidin (KD), and various analogues induced histamine release from rat mast cells. The results obtained with substituted analogues of BK indicated that: 1) the presence of both Arg residues at position 1 and 9 of kinins was favorable to confer histamine-releasing activity, 2) acetylation of the N-terminal amino acid residue led to a drastic reduction of this activity, 3) addition of a D-Arg residue at the N-terminus reduced their activity, as well as trans-4-hydroxyproline (Hyp) substitutions at position 2 or 3,4) D-Arg0 addition and Hyp3 substitution were synergistic in lowering activity, and 5) D-Phe7 substitution led to enhanced histamine-releasing activity. [less ▲]

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See detailGüterverkehrszentren in räumlicher Perspektive. Integration oder Diffusion?
Hesse, Markus UL

in Informationen zur Raumentwicklung (1993), (5/6), 339-350

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See detailUtilization of drug sales data for the epidemiology of chronic diseases: the example of diabetes
Papoz, L.; De Beaufort, Carine UL

in Epidemiology (1993), 4

An indirect method for estimating the prevalence rates of chronic diseases that are treated by specific drugs was proposed in 1988 to European countries in the framework of a European Community concerted ... [more ▼]

An indirect method for estimating the prevalence rates of chronic diseases that are treated by specific drugs was proposed in 1988 to European countries in the framework of a European Community concerted action on diabetes epidemiology. Data on consumption of antidiabetic drugs were collected at the national level in nine countries and at a regional level in two. Using official drug sales data and recent demographic data, we estimated the diabetes prevalence rates in each country or region. The estimated diabetes prevalence in Europe varied from 1.6% in Northern Ireland to 4.7% in Malta. In four countries that already had diabetes prevalence data, the estimation through drug consumption provided figures 3-20% lower than those from field surveys. This study showed a large variety of prescribing habits for diabetic patients in Europe (for example, the proportion of insulin-treated patients varies from 13% to 36%) and underscores the need for a consensus on antidiabetic treatments based on valid clinical research. The proposed approach does not replace field surveys but provides an inexpensive and practical marker of disease frequency and therapeutic attitudes over space and time. [less ▲]

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See detailThe ventralizing effect of the notochord on somite differentiation in chick embryos.
Brand-Saberi, B.; Ebensperger, C.; Wilting, J. et al

in Anatomy & Embryology (1993), 188(3), 239-45

The dorso-ventral pattern formation of the somites becomes manifest by the formation of the epithelially organized dorsal dermomyotome and the mesenchymal ventrally situated sclerotome. While the ... [more ▼]

The dorso-ventral pattern formation of the somites becomes manifest by the formation of the epithelially organized dorsal dermomyotome and the mesenchymal ventrally situated sclerotome. While the dermomyotome gives rise to dermis and muscle, the sclerotome differentiates into cartilage and bone of the axial skeleton. The onset of muscle differentiation can be visualized by immunohistochemistry for proteins associated with muscle contractility, e.g. desmin. The sclerotome cells and the epithelial ventral half of the somite express Pax-1, a member of a gene family with a sequence similarity to Drosophila paired-box-containing genes. In the present study, changes of Pax-1 expression were studied after grafting an additional notochord into the paraxial mesoderm region. The influence of the notochord and the floor-plate on dermomyotome formation and myotome differentiation has also been investigated. The notochord is found to exert a ventralizing effect on the establishment of the dorso-ventral pattern in the somites. Notochord grafts lead to a suppression of the formation and differentiation of the dorsal somitic derivatives. Simultaneously, a widening of the Pax-1-expressing domain in the sclerotome can be observed. In contrast, grafted roof-plate and aorta do not interfere with dorso-ventral patterning of the somitic derivatives. [less ▲]

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See detailA new Pax gene, Pax-9, maps to mouse chromosome 12.
Wallin, J.; Mizutani, Y.; Imai, K. et al

in Mammalian Genome (1993), 4(7), 354-8

Members of the Pax gene family have recently been shown to play important roles in mouse embryogenesis. Of eight so far characterized Pax genes, three have been associated with mouse developmental mutants ... [more ▼]

Members of the Pax gene family have recently been shown to play important roles in mouse embryogenesis. Of eight so far characterized Pax genes, three have been associated with mouse developmental mutants. Here we report the cloning of a new Pax gene, Pax-9. Most of the DNA sequence encoding the highly conserved paired domain has been determined and compared with previously known paired domains. This comparison classifies Pax-9 as a member of the same subgroup as Pax-1/undulated. By analysis of the segregation of a Pax-9 restriction fragment length polymorphism and a large number of simple sequence length polymorphisms in an interspecific C57BL/6 x Mus musculus mollosinus backcross, Pax-9 was mapped close to the D12Nds1 locus on the proximal part of Chromosome (Chr) 12. [less ▲]

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See detailEpithelial factors: modulation of the airway smooth muscle tone
Bertrand, C.; Tschirhart, Eric UL

in Fundamental and Clinical Pharmacology (1993), 7(6), 261-73

The airway epithelium is composed of a heterogeneous population of cells. This epithelial layer is not only a physical barrier but also a target responding to a variety of inflammatory mediators. These ... [more ▼]

The airway epithelium is composed of a heterogeneous population of cells. This epithelial layer is not only a physical barrier but also a target responding to a variety of inflammatory mediators. These cells can respond by releasing contracting and relaxing factors to modulate airway responsiveness. They can also metabolize some of the inflammatory mediators. Epithelial damage is a consistent feature of some respiratory conditions, but whether or not such damage contributes to airway disease is for the moment unknown. This review summarizes the literature on the known and proposed roles of the epithelium in the modulation of the airway smooth muscle tone. [less ▲]

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See detailFrom Sequence Similarity to Structural Homology of Proteins
Sander, C.; Schneider, Reinhard UL

in Computation of Biomolecular Structures, Achievements, Problems and Perspectives (1993)

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See detailQuantum groups and the recovery of the U(3) symmetry in the hamiltonian of the nuclear shell model
del Sol Mesa, Antonio UL

in Journal of Physics: A Mathematical and General (1993)

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See detailUSA im Zeichen der Wende? Klima, Umwelt, Raum, Verkehr.
Hesse, Markus UL

in Kommune: Forum für Politik, Ökonomie, Kultur (1993), 11(3), 41-45

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See detailSubmicrometer Silicon Permeable Base Transistors with Buried CoSi2 Gates
Schüppen, A.; Vescan, L.; Marso, Michel UL et al

in Electronics Letters (1993), 29(1993), 215-217

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See detailDe identiteit van het lichaam.
Biesta, Gert UL

in Comenius (1993), 13(3), 274-290

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See detailAnalysis of the Pax-3 gene in the mouse mutant splotch.
Goulding, M.; Sterrer, S.; Fleming, J. et al

in Genomics (1993), 17(2), 355-63

In a linkage analysis of Pax-3 and splotch no recombinations were found in 117 backcross mice. Molecular analysis of Pax-3 in three alleles of splotch shows a number of significant alterations to the Pax ... [more ▼]

In a linkage analysis of Pax-3 and splotch no recombinations were found in 117 backcross mice. Molecular analysis of Pax-3 in three alleles of splotch shows a number of significant alterations to the Pax-3 gene. In Sp/Sp embryos, cDNA PCR analysis reveals a shortened transcript in which exon 4 of Pax-3 is deleted due to mutation of the splice acceptor site of intron 3. In the Sp4H allele, the Pax-3 gene is deleted and in Spd embryos, Pax-3 expression is significantly lower than that in normal littermate embryos. The linkage analysis, shortened Pax-3 transcript in Sp, and deletion of Pax-3 in Sp4H described here, together with the previous report of an intragenic deletion in Pax-3 in Sp2H mice and the deletion of Pax-3 in Spr mice, provide strong evidence for the allelic identity of Pax-3 and Sp. [less ▲]

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See detailMaxHom
Sander, C.; Schneider, Reinhard UL

in The ZEUS Consortium Massively Parallel Computing, Technical Report PC2 / TR-006-94 (1993)

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See detailA role for Pax-1 as a mediator of notochordal signals during the dorsoventral specification of vertebrae.
Koseki, H.; Wallin, J.; Wilting, J. et al

in Development (1993), 119(3), 649-60

The notochord plays an important role in the differentiation of the paraxial mesoderm and the neural tube. We have analyzed the role of the notochord in somite differentiation and subsequent formation of ... [more ▼]

The notochord plays an important role in the differentiation of the paraxial mesoderm and the neural tube. We have analyzed the role of the notochord in somite differentiation and subsequent formation of the vertebral column using a mouse mutant, Danforth's short-tail (Sd). In this mutant, the skeletal phenotype is most probably a result of degeneration and subsequent loss of the notochord. The Sd gene is known to interact with undulated (un), a sclerotome mutant. Double mutants between Sd and un alleles show an increase in the severity of the defects, mainly in the ventral parts of the vertebrae. We also show that part of the Sd phenotype is strikingly similar to that of the un alleles. As un is known to be caused by a mutation in the Pax-1 gene, we analyzed Pax-1 expression in Sd embryos. In Sd embryos, Pax-1 expression is reduced, providing a potential molecular basis for the genetic interaction observed. A complete loss of Pax-1 expression in morphologically intact mesenchyme was found in the lower thoracic-lumbar region, which is phenotypically very similar to the corresponding region in a Pax-1 null mutant, Undulated short-tail. The sclerotome developmental abnormalities in Sd coincide closely, both in time and space, with notochordal changes, as determined by whole-mount T antibody staining. These findings indicate that an intact notochord is necessary for normal Pax-1 expression in sclerotome cells, which is in turn required for the formation of the ventral parts of the vertebrae. The observed correlation among structural changes of the notochord, Pax-1 expression levels and skeletal phenotypes, suggests that Pax-1 might be an intrinsic mediator of notochordal signals during the dorsoventral specification of vertebrae. [less ▲]

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See detailDegenerations of generalized Krichever-Novikov algebras on tori
Schlichenmaier, Martin UL

in Journal of Mathematical Physics (1993), 34

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See detailSchottky Barriers and Ohmic Contacts on InGaAs, Properties of Lattice-matched and strained InGaAs
Kordoš, P.; Marso, Michel UL

in EMS Datareviews (1993), (INSPEC IEE London), 131-155

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See detailAnger inhibition and family history as modulators of cardiovascular responses to mental stress in adolescent boys
Vögele, Claus UL; Steptoe, Andrew

in Journal of Psychosomatic Research (1993), 37

Sixty boys aged 12-16 took part in an experiment in which physiological and subjective measures were obtained at rest and in response to mental arithmetic and mirror drawing tasks. Blood pressure was ... [more ▼]

Sixty boys aged 12-16 took part in an experiment in which physiological and subjective measures were obtained at rest and in response to mental arithmetic and mirror drawing tasks. Blood pressure was recorded from biological parents, and subjects were subsequently categorized as being at high family risk for cardiovascular disease if either parent had a history of coronary heart disease or hypertension, or a resting blood pressure > or = 140/85 mmHg. Twenty boys were classified as high family risk and forty as low risk. A significant interaction between family risk and a disposition towards anger inhibition was observed, with the greatest systolic blood pressure responses to tasks being recorded in high risk boys who reported high levels of anger inhibition. This effect was maintained after controlling for initial blood pressure level, age and body mass. The cardiac baroreceptor reflex was inhibited during tasks, and was lower in high than low family risk subjects. The results suggest that the tendency to inhibit anger expression interacts with familial factors in determining reactivity patterns that may be indicative of raised risk of future cardiovascular disease. [less ▲]

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See detailReprésentations induites dans les groupes et algèbres de Lie exponentiels
Molitor-Braun, Carine UL

in Travaux Mathématiques (1993), 5

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See detailBenefits of psychological preparation for surgery: a meta-analysis
Johnston, Marie; Vögele, Claus UL

in Annals of Behavioral Medicine : A Publication of the Society of Behavioral Medicine (1993), 15

Analyzed the results of randomized controlled trials of different methods of psychological preparation of adult patients for surgery to determine the benefits sought from psychological preparation ... [more ▼]

Analyzed the results of randomized controlled trials of different methods of psychological preparation of adult patients for surgery to determine the benefits sought from psychological preparation, whether they were achieved, and whether they were likely to be gained. The following 8 outputs were measured in 38 published/unpublished studies: negative affect, pain, pain medication, length of stay, behavioral and clinical indices of recovery, physiological indices, satisfaction, and costs and other outcomes. All benefits analyzed were demonstrated at a level greater than chance in the studies. Procedural information and behavioral instructions showed the most wide-ranging effects in improving measures of all 8 outcomes. Relaxation was also effective, showing benefit on all outcomes except behavioral recovery. Sensory-information, hypnotic, and emotion-focused approaches were not effective in improving outcomes. [less ▲]

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See detailObservations sous Anvers, 3 mars 1992 (n° 6629)
Corbisier, Isabelle UL

in Revue Pratique des Sociétés Civiles et Commerciales (1993), (4), 315-319

Application des principes de la responsabilité aquilienne aux administrateurs d'une ASBL (association sans but lucratif)

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See detailGap junction protein connexin40 is preferentially expressed in vascular endothelium and conductive bundles of rat myocardium and is increased under hypertensive conditions.
Bastide, B.; Neyses, Ludwig UL; Ganten, D. et al

in Circulation Research (1993), 73(6), 1138-49

Gap junction channels consisting of connexin protein mediate electrical coupling between cardiac cells. Expression of two connexins, connexin40 (Cx40) and connexin43 (Cx43), has been studied in ... [more ▼]

Gap junction channels consisting of connexin protein mediate electrical coupling between cardiac cells. Expression of two connexins, connexin40 (Cx40) and connexin43 (Cx43), has been studied in ventricular myocytes from normal and hypertensive rats. Polyclonal affinity-purified rabbit antibodies to Cx43 and Cx40 have been used for immunohistochemical analysis on frozen sections from rat heart. These studies revealed coexpression of Cx43 and Cx40 in ventricular myocytes. In addition, Cx40 is preferentially expressed in three distinct regions: first, in the endothelial layer of the heart blood vessels but not in the smooth muscle layer of the arteries; second, in the ventricular conductive myocardium, particularly in the atrioventricular bundle and bundle branches, where Cx43 is not observed; and third, in the myocyte layers close to the ventricular cavities. These results suggest that Cx40 is preferentially expressed in the fast conducting areas of myocardial tissue. Expression of both Cx40 and Cx43 was also found in immunoblots from normal and hypertensive rat myocardiocytes. Under hypertensive conditions (ie, in spontaneous hypertensive rats and in transgenic rats that exhibit hypertension due to expression of an exogenous renin gene), we found a 3.1-fold increase in Cx40 expression, compared with normal myocardium. Furthermore, we detected a 3.3-fold decrease in Cx43 protein level in transgenic hypertensive rats. The coexpression of Cx40 and Cx43 proteins in rat myocytes, their spatial distribution, and the increased amount of Cx40 protein during cardiac hypertrophy suggest that Cx40 may be involved in mediating fast conduction under normal and pathological conditions. The increased expression of Cx40 in hypertrophic heart may be a compensatory mechanism to increase conduction velocity. [less ▲]

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See detailToshiaki Miyazaki: Pestalozzi und seine Lektüre. Entfaltung des Bewusstseins über Bildung, Schule und Gesellschaft
Tröhler, Daniel UL

in Zeitschrift für Pädagogik. Beiheft (1993), 39(6), 1030-1033

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See detailEstimate of the radial orbit error by complex demodulation
Francis, Olivier UL; Berge, M.

in Journal of Geophysical Research. Solid Earth (1993), 98(B9), 16083-16094

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See detailPREDICTION OF PROTEIN-STRUCTURE BY EVALUATION OF SEQUENCE-STRUCTURE FITNESS - ALIGNING SEQUENCES TO CONTACT PROFILES DERIVED FROM 3-DIMENSIONAL STRUCTURES
OUZOUNIS, C.; SANDER, C.; SCHARF, M. et al

in Journal of Molecular Biology (1993), 232(3), 805-825

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See detailHyperosmotic stress induces immediate-early gene expression in ventricular adult cardiomyocytes.
Wollnik, B.; Kubisch, C.; Maass, A. et al

in Biochemical and biophysical research communications (1993), 194(2), 642-6

Mammalian cells possessing osmosensors have long been described in brain and kidney. The genetic basis of the response to hyperosmotic stress has been well characterized in prokaryotes. In contrast, the ... [more ▼]

Mammalian cells possessing osmosensors have long been described in brain and kidney. The genetic basis of the response to hyperosmotic stress has been well characterized in prokaryotes. In contrast, the genetic response of eukaryotic cells is poorly understood. Therefore we investigated the effect of hypertonic NaCl and sucrose solutions on the transcriptional activation of the immediate-early genes (IEGs) egr-1 and c-fos in isolated ventricular adult rat cardiomyocytes. We observed that even small increases in osmolarity to 315 +/- 5 mosmol/l and 370 +/- 8 mosmol/l by hypertonic NaCl solution resulted in dose-dependent induction of egr-1 (4-and 5-fold) and c-fos (3-and 4-fold), respectively. Hypertonic sucrose solution had the same effect on egr-1 and c-fos mRNA levels while increased sucrose concentration under isotonic conditions had no effect. Cardiomyocytes exposed to hypertonic media did not significantly shrink as shown by a cell length measurement. We conclude that isolated adult cardiomyocytes possess an osmoreceptor mechanism which is able to sense even slight changes in osmolarity and to translate these into a transcriptional response of the myocardial IEG program. [less ▲]

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See detailInnervation of the dura mater encephali of cat and rat: ultrastructure and CGRP/SP-like immunoreactivity
Meßlinger, Karl; Hanesch, Ulrike UL; Baumgärtel, Mathias et al

in Anatomy & Embryology (1993), 188

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See detailLes Règles Uniformes de la CCI pour les garanties sur demande
Prüm, André UL; Mattout, Jean-Pierre

in Banque et Droit (1993)

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See detailVillin-induced growth of microvilli is reversibly inhibited by cytochalasin D.
Friederich, Evelyne UL; Kreis, T. E.; Louvard, D.

in Journal of cell science (1993), 105 ( Pt 3)

Villin is an actin-binding protein that is associated with the cytoskeleton of brush border microvilli. In vitro, villin nucleates, caps or severs actin filaments in a Ca(2+)-dependent manner. In the ... [more ▼]

Villin is an actin-binding protein that is associated with the cytoskeleton of brush border microvilli. In vitro, villin nucleates, caps or severs actin filaments in a Ca(2+)-dependent manner. In the absence of Ca2+, villin organizes microfilaments into bundles. Transfection of a villin-specific cDNA into cultured cells that do not produce this protein results in the growth of long surface microvilli and the reorganization of the underlying actin cytoskeleton. Here we studied the effects of low concentrations of cytochalasin D on the induction of these plasma membrane-actin cytoskeleton specializations. Transfected cells were treated with concentrations of cytochalasin D that prevent the association of actin monomers with the fast-growing end of microfilaments in vitro. In villin-positive cells, cytochalasin D inhibited the growth of microvilli and promoted the formation of rodlet-like actin structures, which were randomly distributed throughout the cytoplasm. The formation of these structures was dependent on large amounts of villin and on the integrity of an actin-binding site located at the carboxy terminus of villin, which is required for microfilament bundling in vitro and for the growth of microvilli in vivo. The effect of cytochalasin D was reversible. The observation of living cells by video-imaging revealed that when cytochalasin D was removed, rapid disassembly of actin rodlets occurred after a lag phase. The present data stress the important role of the plasma membrane in the organization of the actin cytoskeleton and suggest that the extension of the microvillar plasma membrane is dependent on the elongation of microfilaments at their fast-growing end. Inhibition of microfilament elongation near the plasma membrane by cytochalasin D may result in the 'random' nucleation of actin filaments throughout the cytoplasm. On the basis of the present data, we propose that villin is involved in the assembly of the microvillar actin bundle by a mechanism that does not prevent monomer association with the preferred end of microfilaments. For instance, villin may stabilize actin filaments by lateral interactions. The functional importance of the carboxy-terminal F-actin binding site in such a mechanism is stressed by the fact that it is required for the formation of F-actin rodlets in cytochalasin D-treated cells. Finally, our data further emphasize the observations that the effects of cytochalasin D in living cells can be modulated by actin-binding proteins. [less ▲]

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See detailImmediate-early gene induction by repetitive mechanical but not electrical activity in adult rat cardiomyocytes.
Kubisch, C.; Wollnik, B.; Maass, A. et al

in FEBS letters (1993), 335(1), 37-40

Mechanical factors are thought to play an important role in the induction of myocardial hypertrophy. Yet, it is not known whether active contraction induces genes that probably represent initial steps in ... [more ▼]

Mechanical factors are thought to play an important role in the induction of myocardial hypertrophy. Yet, it is not known whether active contraction induces genes that probably represent initial steps in the hypertrophic response in the adult myocardium--and if so, whether the mechanical or the electrical component of the twitch governs this response. We therefore investigated whether electrical stimulation of contraction was able to induce the immediate-early genes (IEGs) egr-1 and c-fos in adult rat cardiomyocytes. Cyclical contraction led to an increase in egr-1 and c-fos mRNA levels within 30 min. Full inhibition of contraction during electrostimulation by the Ca(2+)-desensitizer 2,3-butanedione monoxime (BDM) totally blocked this IEG-response without altering membrane potential. These data suggest that in adult myocardium, the mechanical rather than the electrical activity is responsible for the IEG-response during active twitch. [less ▲]

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See detailInduction of immediate-early genes by angiotensin II and endothelin-1 in adult rat cardiomyocytes.
Neyses, Ludwig UL; Nouskas, J.; Luyken, J. et al

in Journal of hypertension (1993), 11(9), 927-34

OBJECTIVE: Few molecular signals for induction of myocardial hypertrophy have been identified. This study was carried out to investigate the action of angiotensin II and endothelin on the growth- and ... [more ▼]

OBJECTIVE: Few molecular signals for induction of myocardial hypertrophy have been identified. This study was carried out to investigate the action of angiotensin II and endothelin on the growth- and differentiation-related genes Egr-1 (early growth response gene 1) and c-fos in isolated adult rat cardiomyocytes. METHODS: Cardiac myocytes from male Wistar-Kyoto rats were isolated and incubated with angiotensin II and endothelin-1 in Dulbecco's modified Eagle's medium. RNA was isolated and blotted, and densitometric analysis was performed. All experiments were repeated at least three times. RESULTS: Endothelin-1 (10(-7) mmol/l) induced a 20-25-fold rise in Egr-1 messenger RNA within 15 min. This effect was dose-dependent. c-fos was induced 10-20-fold within 15 min with similar dose-response characteristics. Angiotensin II also induced Egr-1 and c-fos with kinetics similar to endothelin but a cofactor from fetal calf serum was needed for full c-fos expression. The protein kinase C activator phorbol 12-myristate 13-acetate also induced Egr-1. CONCLUSIONS: The results identify Egr-1 and c-fos as target genes for the action of endothelin and angiotensin II in the adult myocardium suggesting that induction of the genes may be part of the signal transduction pathway for angiotensin II and endothelin in the myocardium. [less ▲]

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See detailTHE HSSP DATA-BASE OF PROTEIN STRUCTURE-SEQUENCE ALIGNMENTS
SANDER, C.; Schneider, Reinhard UL

in Nucleic Acids Research (1993), 21(13), 3105-3109

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See detailAtmospheric load response of the oceans determined using Geosat data
van Dam, Tonie UL; Wahr, John

in Geophysical Journal International (1993), 113(1), 1-16

Approximately one year's worth of altimeter-derived sea-surface heights are compared with global sea-level pressure fields to verify the open ocean inverted barometer response (-1 cm mb-1). When pressure ... [more ▼]

Approximately one year's worth of altimeter-derived sea-surface heights are compared with global sea-level pressure fields to verify the open ocean inverted barometer response (-1 cm mb-1). When pressure is fit to the sea-surface height along individual altimeter tracks, the response is found to be only 60–70 per cent of the theoretical response or approximately -0.6 to -0.7 cm mb-1. Fits at fixed geographic locations show a clear dependence on latitude. There is a steady decrease in the absolute value o the regression coefficient between 70° and 20°, and then an abrupt increase again closer to the equator. A simple error analysis demonstrates that errors in the pressure data would reduce the along-track regression values, as is observed, and could produce a similar latitude dependence. But, the errors are unlikely to be large enough to explain the entire departure from inverted barometer. We estimate that pressure errors are apt to perturb the along-track track results by no more than about 0.1-0.2 cm mb-1. The possibility that the remaining disagreement is due to a global coherence between wind- and pressure-driven sea-surface height variability is considered. Winds driven by the pressure gradients of synoptic storms induce a sea-surface height response that is opposite in direction to that caused by the pressure cell. the wind-driven response is estimated for a stationary storm over a homogeneous barotropic ocean and for a moving storm over a two-layer baroclinic ocean by modeling the pressure cell as an idealized Gaussian distribution. the model results indicate that the wind-induced sea-surface height depends on both the radius and the translational velocity of the pressure cell. But, the winds associated with storms moving at average speeds of 10 ms-1 are apt to lower the theoretical pressure response in the model by only approximately 0.1 cm mb-1. the surface stress associated with those winds has the same latitudinal trend between 70° and 20° as the regression coefficients. But, the response of the ocean to that stress does not appear to exhibit the same trend. Nevertheless, the abrupt change in the regression coefficients near the equator suggests the apparent non-inverted barometer response may reflect a real change in sea-surface height related to atmospheric forcing (though the results near the equator are not as well defined as those at higher latitudes). [less ▲]

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See detailLa validité de la clause de révision unilatérale des taux d'intérêt en Europe - Droits belge, luxembourgeois, néerlandais et allemand
Corbisier, Isabelle UL

in Revue des Affaires Européennes [= RAE] = Law & European Affairs (1993), (3), 27-40

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See detailThe genetics of skeletal development.
Balling, Rudi UL; Ebensperger, C.; Hoffmann, I. et al

in Annales de Génétique (1993), 36(1), 56-62

A genetic analysis of biologic processes has provided substantial advances in developmental biology. Whereas the genetic analysis of Drosophila is a potent system, recently developed tools have enabled a ... [more ▼]

A genetic analysis of biologic processes has provided substantial advances in developmental biology. Whereas the genetic analysis of Drosophila is a potent system, recently developed tools have enabled a genetic analysis of the development of vertebrates. For these studies, numerous mouse mutants are available and many more will be introduced in the near future. Mutations involving the skeleton are easy to detect. This article reports the phenotype and molecular analysis of two mutant mouse strains with skeletal abnormalities, undulated (un) and Danforth's short tail (Sd). The role of the corresponding genes in skeletal development of these two mutants and the basis for their genetic interaction are discussed. [less ▲]

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See detailVerhaltensmedizin. Ein psychobiologischer Ansatz zur Behandlung körperlicher Krankheiten
Florin, Irmela; Tuschen-Caffier, Brunna; Vögele, Claus UL

in Verhaltensmodifikation und Verhaltensmedizin (1993), 1/2

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See detailMapping of the Mod-1 locus on mouse chromosome 9.
Nass, S. J.; Olowson, M.; Miyashita, N. et al

in Mammalian Genome (1993), 4(6), 333-7

A new method for typing the Mod-1 locus on mouse Chromosome (Chr) 9 was developed, based on restriction fragment length polymorphism (RFLP) within a polymerase chain reaction (PCR)-amplified fragment. The ... [more ▼]

A new method for typing the Mod-1 locus on mouse Chromosome (Chr) 9 was developed, based on restriction fragment length polymorphism (RFLP) within a polymerase chain reaction (PCR)-amplified fragment. The new method led us to revise the strain distribution pattern (SDP) of Mod-1 in the BXD (C57BL/6J x DBA/2J) and AKXD (AKR/J x DBA/2J) recombinant inbred (RI) strains. The new SDP eliminates several previously reported examples of double recombination events between Mod-1 and the closest flanking loci in the BXD and AKXD strains. In the BXD strains, the revised SDP of Mod-1 was identical to that of the Mod-1-related D9Rtil locus. Thus, the identity of D9Rtil as a Mod-1-related locus rather than Mod-1 itself is in question. The method was also applied to an interspecific backcross panel between an inbred strain of Mus musculus molossinus (MSM/Ms) and C57BL/6J to map Mod-1 with respect to surrounding microsatellite loci, defining the proximal localization of Mod-1 with respect to D9Mit10 with a genetic distance of 0.6 +/- 0.6 cM. [less ▲]

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See detailA review of the recent epidemiological data on the worldwide incidence of type 1 (insulin dependent) diabetes mellitus
Karvonen, M.; Tuomilehto, J.; Libman, J. et al

in Diabetologia (1993), 36

Nearly 70 registries from more than 40 countries have collected and published incidence data of childhood Type 1 (insulin-dependent) diabetes mellitus up to the end of the 1980s. The majority of incidence ... [more ▼]

Nearly 70 registries from more than 40 countries have collected and published incidence data of childhood Type 1 (insulin-dependent) diabetes mellitus up to the end of the 1980s. The majority of incidence data comes from regions of high incidence i.e. from Europe and North America. All these published data facilitate the descriptive comparison of incidence and variation of the occurrence of Type 1 diabetes roughly throughout the northern hemisphere. The aim of this paper is to review and compare the most recent epidemiology data on the incidence of Type 1 diabetes among children under the age of 15 years. A clear difference in incidence appeared between northern and southern hemisphere with no countries below the equator having an incidence greater than 15.0 per 100,000. In contrast above the equator the disease is common. Between continents the variation in incidence showed that the lowest incidences were found in Asia, followed by Oceania (Australia and New Zealand), South and North America, and the highest rates were in Europe. The incidence varied from 0.6 per 100,000 in Korea and Mexico to 35.3 per 100,000 in Finland showing prominent worldwide variation in incidence of Type 1 diabetes. The largest intracontinental variation in incidence appeared in Europe, varying from the highest in Finland to the lowest (4.6 per 100,000) in northern Greece. The highest incidence in the world was in northern Europe, but within the continent scale there were some striking exceptions from the overall level of incidence.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailFine genetic mapping of the proximal part of mouse chromosome 2 excludes Pax-8 as a candidate gene for Danforth's short tail (Sd).
Koseki, H.; Zachgo, J.; Mizutani, Y. et al

in Mammalian Genome (1993), 4(6), 324-7

Danforth's short tail (Sd) is a semidominant mutation of the mouse with effects on the skeleton and the urogenital system. In view of its phenotype and its position in the proximal part of Chromosome (Chr ... [more ▼]

Danforth's short tail (Sd) is a semidominant mutation of the mouse with effects on the skeleton and the urogenital system. In view of its phenotype and its position in the proximal part of Chromosome (Chr) 2, three genes qualified as possible candidates: Pax-8, a paired box-containing gene; Midkine (Mdk), a retinoic acid-responsive gene; and a new locus (Etl-4) identified by enhancer trapping with a lacZ reporter gene which showed expression in the notochord, the mesonephric mesenchyme, and the apical ectodermal ridge. Three different backcrosses involving all three genes in different combinations were set up and analyzed. From our results we conclude that Sd, Etl-4, Pax-8, and Mdk are independent loci, with Etl-4 being the closest genetic marker (1.1 +/- 1.4 cM) to the Danforth's short tail (Sd) gene. [less ▲]

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See detailInsulin autoantibodies and immune response to human insulin therapy in 24 type 1 (insulin-dependent) diabetic children: superiority of radio binding assay over solid phase assay
De Beaufort, Carine UL; Sodoyez, J. C.; Koch, M. et al

in Diabetes Research and Clinical Practice (1993), 21(1), 19-24

To evaluate the immunization pattern against human insulin, 24 newly diagnosed diabetic children (12 females, 12 males; mean age: 7 ± 4 years) were treated from diagnosis onwards with semisynthetic human ... [more ▼]

To evaluate the immunization pattern against human insulin, 24 newly diagnosed diabetic children (12 females, 12 males; mean age: 7 ± 4 years) were treated from diagnosis onwards with semisynthetic human insulin (NOVO). Informed consent was obtained from all parents. Blood samples were taken before, 1, 2, 3, 4, 6 and 8 weeks after the start of therapy and, thereafter, at monthly intervals for 2 years. Insulin (auto) antibodies (I(A)A) were measured by radio binding assay (RBA) and by enzyme-linked immunosorbent assay (ELISA). IAA, determined by RBA, were detected in eight children. Using ELISA, IgM IA were not detected after onset of therapy. By contrast, IgG IA were found in 8 children after 2 weeks of treatment and in 12 after 1 month. Using RBA, all children had IA after 2 months of therapy, whereas with ELISA, IA remained undetectable during the study period in 8 out of 24 patients. These results confirm previous observations suggesting that the 2 methods are not interchangeable and yield different estimations of the insulin immune reaction, not only before but also after the start of insulin therapy. In addition, the detection of IA by RBA in all treated patients unambiguously demonstrates that human insulin is immunogenic in man. © 1993. [less ▲]

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See detailSade between Labov and Greimas
Weber, Jean-Jacques UL; Colas-Blaise, Marion UL

in Revue Belge de Philologie et d'Histoire (1993), 71

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See detailAn epithelial-dependent contracting factor induced by calcium influx in guinea-pig trachea
Bertrand, C.; Da Silva, A.; Landry, Y. et al

in Pulmonary Pharmacology (1993), 6(1), 69-76

The effects of epithelium removal were studied on the contraction induced by Ca2+ in K(+)-depolarizing solution, and by the calcium ionophore A 23187 in guinea-pig isolated tracheal strips. Epithelium ... [more ▼]

The effects of epithelium removal were studied on the contraction induced by Ca2+ in K(+)-depolarizing solution, and by the calcium ionophore A 23187 in guinea-pig isolated tracheal strips. Epithelium removal reduced the maximal response to Ca2+ in K(+)-depolarizing solution and caused a significant shift to the right of the Ca2+ concentration-response curves. The contraction induced by the calcium ionophore A 23187 (10(-6) M) was also markedly reduced by epithelium removal. These results suggest the occurrence of an epithelium-derived contracting factor. The effects of hexamethonium, atropine, spantide and thiorphan showed that acetylcholine and neurokinins play a minor role in the Ca(2+)-induced contraction. The epithelium-dependent potentiation of the calcium- and of the A 23187-induced contractions was inhibited by an antibody selective for rat calcitonin gene-related peptide (rCGRP alpha). Therefore, CGRP-like immunoreactive material may be part of the epithelium-dependent contracting factor of guinea-pig trachea. Comparison of concentration-response curves for rCGRP alpha in epithelium-free and in intact guinea-pig tracheal strips suggests that an epithelium-dependent contracting factor may be mobilized by CGRP. [less ▲]

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See detailKondratieff-Zyklen, Gibson-Paradoxon und Klassischer Goldstandard
Klump, Rainer UL

in Vierteljahresschrift für Sozial- und Wirtschaftsgeschichte (1993)

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See detailFremdenfeindliche Gewalt
Willems, Helmut UL; Eckert, Roland

in Neue Justiz: Zeitschrift für Rechtsentwicklung und Rechtsprechung (1993), 47(11), 481-485

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See detailThe genetic map around the tail kinks (tk) locus on mouse chromosome 9.
Imai, K.; Nass, S. J.; Olowson, M. et al

in Mammalian Genome (1993), 4(10), 560-4

Tail kinks (tk) is a classical mouse skeletal mutation, located on Chromosome (Chr) 9. As the first step for the positional cloning of the tk gene, we have established a genetic map of a region ... [more ▼]

Tail kinks (tk) is a classical mouse skeletal mutation, located on Chromosome (Chr) 9. As the first step for the positional cloning of the tk gene, we have established a genetic map of a region surrounding the tk locus by generating a backcross segregating for tk. From this backcross, 1004 progeny were analyzed for the coat-color phenotype of the proximally located dilute (d) gene and for the distally flanking microsatellite marker, D9Mit12. Fifty-six recombinants between d and tk and 75 recombinants between tk and D9Mit12 were identified, completing a panel of 130 recombinants including one double recombinant. This panel allowed us to map five microsatellite loci as well as d and Mod-1 with respect to tk. We show that one of the microsatellite markers mapped, D9Mit9, does not recombine at all with tk in our backcross. This indicates that the D9Mit9 locus will serve as a good starting point for a chromosomal walk to the tk gene. [less ▲]

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See detailDas Justizwesen im Staate Luxemburg
Ravarani, Georges UL

in Forum für Politik, Gesellschaft und Kultur in Luxemburg (1993), (144),

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See detailPROGRESS IN PROTEIN-STRUCTURE PREDICTION
ROST, B.; Schneider, Reinhard UL; SANDER, C.

in Trends in Biochemical Sciences - Regular Edition (1993), 18(4), 120-123

Prediction of protein secondary structure is an old problem and progress has been slow. Recently, spectacular success has been claimed in the blind prediction of the catalytic subunit of the cAMP ... [more ▼]

Prediction of protein secondary structure is an old problem and progress has been slow. Recently, spectacular success has been claimed in the blind prediction of the catalytic subunit of the cAMP-dependent protein kinase. When predictions in this and other test cases are assessed critically, some claims of prediction success turn out to be exaggerated, but a kernel of real progress remains: protein structure prediction can be improved substantially when a family of related sequences is available. Enough so that molecular biologists equipped with a new amino acid sequence and a multiple sequence alignment in hand may be tempted to test the new prediction methods. [less ▲]

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See detailNoradrenergic and opioid systems interact to alter the detection of noxious thermal stimuli and facial scratching in monkeys
Thomas, David A; Anton, Fernand UL; Williams, GM et al

in Pain (1993), 55(1), 63-70

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See detailUmstrukturierung des Tourismus auf Rügen - Chance oder Risiko für die Region?
Helfer, Malte UL

in Greifswalder Beiträge zur Regional-, Freizeit- und Tourismusforschung (1993), 4

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See detailThe relationship between heart rate responsiveness in the laboratory and in the field: two studies
Johnston, Derek William; Vögele, Claus UL; Anastasiades, Pavlos et al

in Journal of Psychophysiology (1993), (7), 217-229

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See detailMontesquieu face au mariage. Alliances matrimoniales entre noblesse de robe et négociants à Bordeaux au début du XVIIIe siècle
Voss, Peter UL

in Revue Historique de Bordeaux et du Département de la Gironde (1992), 34(2), 41-54

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See detailBanken und Wirtschaftskreislauf: Makroökonomische Konsequenzen einer Portfoliotheorie des Giralgeldangebotes
Klump, Rainer UL

in Jahrbucher für Nationalokonomie und Statistik (1992)

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See detailNeurokinin A-like immunoreactivity in articular afferents of the cat
Hanesch, Ulrike UL; Heppelmann, Bernd; Schmidt, Robert

in Brain Research (1992), 586

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See detailThe molecular and genetic analysis of mouse development.
Gossler, A.; Balling, Rudi UL

in European Journal of Biochemistry (1992), 204(1), 5-11

This review describes some recent advances in the molecular-genetic analysis of mouse development. Reversed genetics and gene assignment have been used to isolate genes affected in developmental mutations ... [more ▼]

This review describes some recent advances in the molecular-genetic analysis of mouse development. Reversed genetics and gene assignment have been used to isolate genes affected in developmental mutations. The establishment of a high-density molecular-genetic map promises to facilitate cloning of additional genes with developmental functions. Based on molecular, biochemical or other biological criteria many mouse genes that code for transcriptional regulators, growth-factor-like molecules and their receptors have been isolated. The role of these genes during development can be analysed in vivo after producing targeted mutations. Mutations can be generated by homologous recombination in the genome of embryonic stem cells and can then be introduced into the mouse germ line by means of germ-line chimaeras. Additional approaches employing stem cells to identify and mutate putative developmental genes are coming into use. [less ▲]

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See detailWaardenburg's syndrome patients have mutations in the human homologue of the Pax-3 paired box gene.
Tassabehji, M.; Read, A. P.; Newton, V. E. et al

in Nature (1992), 355(6361), 635-6

Waardenburg's syndrome (WS) is an autosomal dominant combination of deafness and pigmentary disturbances, probably caused by defective function of the embryonic neural crest. We have mapped one gene for ... [more ▼]

Waardenburg's syndrome (WS) is an autosomal dominant combination of deafness and pigmentary disturbances, probably caused by defective function of the embryonic neural crest. We have mapped one gene for WS to the distal part of chromosome 2. On the basis of their homologous chromosomal location, their close linkage to an alkaline phosphatase gene, and their related phenotype, we suggested that WS and the mouse mutant Splotch might be homologous. Splotch is caused by mutation in the mouse Pax-3 gene. This gene is one of a family of eight Pax genes known in mice which are involved in regulating embryonic development; each contains a highly conserved transcription control sequence, the paired box. Here we show that some families with WS have mutations in the human homologue of Pax-3. Mutations in a related gene, Pax-6, which, like Pax-3, has both a paired box and a paired-type homeobox sequence, cause the Small-eye mutation in mice and aniridia in man. Thus mutations in the Pax genes are important causes of human developmental defects. [less ▲]

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See detailBonAccord: un nouveau didacticiel de traduction semi-intelligent
Weber, Jean-Jacques UL

in Bulletin Nouvelles Technologies et Education (1992), 7

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See detailEpithelial modulation of thromboxane A2 and PAF involvement in IgE- and IgG-mediated guinea pig anaphylaxis
Bertrand, C.; Tschirhart, Eric UL; Landry, Y.

in Immunopharmacology (1992), 22(2), 115-25

The role of prostanoids and platelet-activating factor (PAF) was studied in the in vitro response of guinea pig trachea to immunochallenge according to the presence or the absence of the epithelial layer ... [more ▼]

The role of prostanoids and platelet-activating factor (PAF) was studied in the in vitro response of guinea pig trachea to immunochallenge according to the presence or the absence of the epithelial layer and to the sensitization procedure leading to the preferential synthesis of immunoglobulin E (IgE) or immunoglobulin G (IgG) antibodies. Indomethacin, a cyclooxygenase inhibitor, potentiated the antigen-induced contractions both in IgE and IgG models, suggesting the involvement of relaxant prostaglandins (PGs), independently of the presence of the airway epithelium. UK-38485, a thromboxane synthetase inhibitor, did not modify the tracheal response to antigen in the IgE model. However, this compound enhanced the maximum contractile response to antigen of the intact tracheal strips of IgG-sensitized guinea pig, but reduced the contractile response of the epithelium-free tracheal strips. Two potent non-structurally related PAF antagonists, Ro 19-3704 and BN 52021, reduced antigen-induced contraction of the epithelium-free tracheal strips in the IgE model. In contrast, these compounds did not affect the contractile responses of the preparations in the IgG model. These results suggest the selective implication of thromboxane A2 and PAF, in IgG- and IgE-mediated guinea pig anaphylaxis respectively. Finally, these results indicate that thromboxane A2 (TXA2) and PAF are potent inducers of epithelium-derived mediators. [less ▲]

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See detailAngiotensin II induces formation of the early growth response gene-1 protein in rat vascular smooth muscle cells.
Sachinidis, A.; Weisser, P.; Ko, Y. et al

in FEBS letters (1992), 313(2), 109-12

The effect of angiotensin II (Ang II) on the early growth response gene-1 (Egr-1) mRNA, on the Egr-1 protein and on the phosphoinositide PI turnover signalling system was investigated in the presence and ... [more ▼]

The effect of angiotensin II (Ang II) on the early growth response gene-1 (Egr-1) mRNA, on the Egr-1 protein and on the phosphoinositide PI turnover signalling system was investigated in the presence and absence of EXP3174, a potent non-peptide Ang II receptor antagonist. Ang II induced an accumulation of 3.4 kb Egr-1 mRNA and the 80 kDa Egr-1 protein, with a maximum at 30 min and 60 min, respectively. EXP3174 blocked the Ang II-induced increase of inositol phosphates, Egr-1 mRNA and the Egr-1 protein, suggesting the involvement of the PI signalling system by the expression of the Egr-1 gene. [less ▲]

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See detailString branchings on complex tori and algebraic representations of generalized Krichever-Novikov algebras
Ruffing, Andreas; Deck, Thomas; Schlichenmaier, Martin UL

in Letters in Mathematical Physics (1992), 26(1), 23-32

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See detailMolecular biology of oncogenes and cardiovascular hypertrophy.
Neyses, Ludwig UL; Vetter, H.

in Journal of hypertension (1992), 10(12), 1447-52

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See detailIncidence of childhood-onset insulin-dependent diabetes mellitus: the EURODIAB ACE Study
Green, A.; Patterson, C.C.; Gale, E.A. et al

in Lancet (1992), 339(8798), 905-909

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See detailIn vivo analysis of functional domains from villin and gelsolin.
Finidori, J.; Friederich, Evelyne UL; Kwiatkowski, D. J. et al

in The Journal of cell biology (1992), 116(5), 1145-55

Transfected CV1 cells were used to compare the in vivo effects of various domains of villin and gelsolin. These two homologous actin modulating proteins both contain a duplicated severin-like sequence ... [more ▼]

Transfected CV1 cells were used to compare the in vivo effects of various domains of villin and gelsolin. These two homologous actin modulating proteins both contain a duplicated severin-like sequence. Villin has in addition a carboxy-terminal domain, the headpiece, which accounts for its bundling activity. The effects of the villin-deleted mutants were compared with those of native villin. Our results show that essential domains of villin required to induce the growth of microvilli and F-actin redistribution are present in the first half of the core and in the headpiece. We also show that the second half of the villin core cannot be exchanged by its homolog in gelsolin. When expressed at high levels of CV1 cells, full length gelsolin completely disrupted stress fibers without change of the cell shape. Addition of the villin headpiece to gelsolin had no effect on the phenotype induced by gelsolin alone. Expression of the first half of gelsolin induced similar modifications as capping proteins and rapid cell mortality; this deleterious effect on the cell structure was also observed when the headpiece was linked to the first half of gelsolin. In cells expressing the second half of gelsolin, a dotted F-actin staining was often seen. Moreover elongated dorsal F-actin structures were observed when the headpiece was linked to the second gelsolin domain. These studies illustrate the patent in vivo severing activity of gelsolin as well as the distinct functional properties of villin core in contrast to gelsolin. [less ▲]

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See detailEnhancement of the Schottky Barrier Height on n-InGaAs by Thin InP Interlayers
Kordoš, P.; Marso, Michel UL; Lüth, H.

in Journal of Electrical Engineering (1992), 44(1992), 367-371

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See detailA graph theoretic criterion for determining the number of clusters in a data set
Krolak-Schwerdt, Sabine UL; Eckes, Thomas

in Multivariate Behavioral Research (1992), 27

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See detailInteractions between Earth and ocean tides
Francis, Olivier UL

in Marées Terrestres Bulletin d'Informations (1992), 112

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See detailEmotional coping and tonic blood pressure as determinants of cardiovascular reactions to mental stress
Vögele, Claus UL; Steptoe, Andrew

in Journal of Hypertension (1992), 10

OBJECTIVES: The aim was to assess the combined influence of biological risk for hypertension and patterns of emotional control upon cardiovascular responses to mental stress tests. DESIGN: The study ... [more ▼]

OBJECTIVES: The aim was to assess the combined influence of biological risk for hypertension and patterns of emotional control upon cardiovascular responses to mental stress tests. DESIGN: The study involved the administration of mental stress tests in the laboratory, designed to elicit substantial blood pressure and heart rate responses accompanied by suppression of cardiac baroreflex sensitivity. METHODS: Thirty-seven young men were selected as being at relatively high or low risk through having high or low normal blood pressure. Blood pressure, recorded continuously using the Finapres, heart rate, cardiac baroreflex sensitivity, skin conductance and respiration rate were monitored at rest and during mental arithmetic and mirror drawing tasks. RESULTS: Hypertension risk category had no overall effect upon cardiovascular reactions to mental stress. Two dimensions of emotional coping were identified through factor analysis of psychological questionnaires--anxious emotional inhibition (ratings of trait anxiety, anger in and self-concealment), and anger experience and expression (ratings of trait anger and anger out). Subjects with high and low scores on these dimensions were equally represented in the two blood pressure risk categories. Hypertensive risk interacted with anxious emotional inhibition, with the greatest systolic blood pressure and heart rate responses (accompanied by cardiac baroreflex inhibition) being recorded in subjects at high risk coupled with high anxious emotional inhibition. Anger experience and expression did not interact with hypertension risk, but had a direct effect upon cardiovascular responses to mental stress. No differences were seen in skin conductance or respiratory responses, suggesting specific disturbances of cardiovascular regulation. CONCLUSIONS: The results suggest that normotensives at risk for future hypertension are likely to show heightened stress-related cardiovascular responses if they also tend to inhibit the expression of negative emotions. This pattern may be relevant to the postulated links between hypertension and emotional inhibition. [less ▲]

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See detailQuestions actuelles en droit allemand des sociétés : de quoi nourrir la réflexion au sein d'un droit belge en mutation
Corbisier, Isabelle UL

in Revue Pratique des Sociétés Civiles et Commerciales (1992), (3), 153-209

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See detailVom Vorteil, ein Außenseiter zu sein
Steffgen, Georges UL

in Sportpsychologie (1992), 6(1), 22-23

Im Sport beobachtet man häufig das Phänomen, daß Außenseiter „übermächtige“ Gegner schlafen. Gibt es dafür eine plausible Erklärung?

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See detailNicotinamid
De Beaufort, Carine UL

in Diabetes, prevention and therapy (1992), 6

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See detailTheoretische Pedagogiek (De AERA Annual Meeting: Chicago 1991)
Miedema, S.; Biesta, Gert UL

in Pedagogische Studiën: Tijdschrift voor Onderwijskunde en Opvoedkunde (1992), 68

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See detailProtons selectively induce lasting excitation and sensitization to mechanical stumulation of nociceptors in rat skin, in vitro
Steen, Kai h; Reeh, Peter-Werner; Anton, Fernand UL et al

in Journal of Neuroscience (1992), 12(1), 86-95

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See detailDie historische Bäderarchitektur des Ostseebades Sellin auf Rügen - wertvolles Kapitel für die Entwicklung des Fremdenverkehrs
Helfer, Malte UL

in Greifswalder Beiträge zur Regional-, Freizeit- und Tourismusforschung (1992), 3

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See detailBarcelona '92 - Psychologische Betreuung einer Olympia-Delegation
Steffgen, Georges UL

in Sportpsychologie (1992), 6(4), 29-30

In seiner Funktion als beratender Psychologe des Olympischen Komitees von Luxemburg (C.O.S.L.) hat der Autor die luxemburgische Olympia Delegation bei den Olympischen Spielen in Barcelona begleitet. Im ... [more ▼]

In seiner Funktion als beratender Psychologe des Olympischen Komitees von Luxemburg (C.O.S.L.) hat der Autor die luxemburgische Olympia Delegation bei den Olympischen Spielen in Barcelona begleitet. Im Rahmen des vorliegenden Erfahrungsberichtes zeigt er seine Aktivitäten im Vorfeld wie auch während der Olympischen Spiele auf. [less ▲]

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See detailSequence analysis of polymerase chain reaction amplified t(14;18) chromosomal breakpoints in formalin fixed, paraffin wax embedded follicular lymphoma.
Volkenandt, M.; Koch, O.; Fanin, R. et al

in Journal of clinical pathology (1992), 45(3), 210-2

AIMS: To determine whether junctional sequences of rearranged chromosomes can be amplified by use of the polymerase chain reaction (PCR) and whether direct sequence analysis of the PCR products is ... [more ▼]

AIMS: To determine whether junctional sequences of rearranged chromosomes can be amplified by use of the polymerase chain reaction (PCR) and whether direct sequence analysis of the PCR products is possible, using DNA from formalin fixed, paraffin wax embedded biopsy specimens. METHODS: DNA was extracted from paraffin wax embedded, formalin fixed lymphoma specimens, and junctional sequences of rearranged chromosomes were amplified by the PCR. The products were used as templates for asymmetrical PCR. Subsequently, direct sequence analysis was performed using the chain termination method. RESULTS: Formalin fixed, paraffin wax embedded biopsy specimens and PCR amplification could be used to determine the nucleotide sequences of junctional regions of rearranged chromosomes t(14;18) from patients with follicular lymphoma. CONCLUSION: The identification of junctional sequences of the translocation in follicular lymphoma provides a molecular "fingerprint" of t(14;18) of the lymphoma of an individual patient and can be used for the detection of clone specific DNA in any biopsy tissue obtained from the patient. The strategy used for rapid sequence analysis of PCR amplified DNA sequences will be useful in many areas of molecular pathology. [less ▲]

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See detailStates and traits in psychological assessment.
Steyer, Rolf; Ferring, Dieter UL; Schmitt, Manfred J.

in European Journal of Psychological Assessment (1992), 8(2)

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See detailPax1, a member of the paired box-containing class of developmental control genes, is mapped to human chromosome 20p11.2 by in situ hybridization (ISH and FISH).
Schnittger, S.; Rao, V. V.; Deutsch, U. et al

in Genomics (1992), 14(3), 740-4

Pax-1, a member of a murine multigene family, belongs to the paired box-containing class of developmental control genes first identified in Drosophila. The Pax-1 gene encodes a sequence-specific DNA ... [more ▼]

Pax-1, a member of a murine multigene family, belongs to the paired box-containing class of developmental control genes first identified in Drosophila. The Pax-1 gene encodes a sequence-specific DNA-binding protein with transcriptional activating properties and has been found to be mutated in the autosomal recessive mutation undulated (un) on mouse chromosome 2 with vertebral anomalies along the entire rostrocaudal axis. By radioactive in situ hybridization (ISH) using a fragment from the murine Pax-1 paired box that is almost identical to the respective sequences from the cognate human gene HuP48 and fluorescence in situ hybridization (FISH) using a complete mouse Pax-1 cDNA, we have assigned the human homologue of murine Pax-1, the PAX1 locus, to chromosome 20p. The map position of PAX1 after FISH (FL-pter value of 0.34 +/- 0.04) corresponds to band p11.2. These results confirm the exceptional homology between human chromosome 20 and the distal segment of mouse chromosome 2, extending from bands F to G, and add PAX1 to the group of genes on 20p like PTPA, PRNP, SCG1, BMP2A, which are located in proximity on both chromosomes. [less ▲]

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See detailLogistik – Zauberwort der Raumpolitik
Hesse, Markus UL

in Kommune: Forum für Politik, Ökonomie, Kultur (1992), 10(3), 52-54

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See detail«Nez à nez avec l'humour»
Roelens, Nathalie UL

in Poétique (1992)

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See detailLa loi du 5 août 1991 sur la protection de la concurrence économique
Corbisier, Isabelle UL

in Le droit des affaires = Het ondernemingsrecht (1992), 24

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See detailSELECTION OF REPRESENTATIVE PROTEIN DATA SETS
HOBOHM, U.; SCHARF, M.; Schneider, Reinhard UL et al

in Protein Science : A Publication of the Protein Society (1992), 1(3), 409-417

The Protein Data Bank currently contains about 600 data sets of three-dimensional protein coordinates determined by X-ray crystallography or NMR. There is considerable redundancy in the data base, as many ... [more ▼]

The Protein Data Bank currently contains about 600 data sets of three-dimensional protein coordinates determined by X-ray crystallography or NMR. There is considerable redundancy in the data base, as many protein pairs are identical or very similar in sequence. However, statistical analyses of protein sequence-structure relations require nonredundant data. We have developed two algorithms to extract from the data base representative sets of protein chains with maximum coverage and minimum redundancy. The first algorithm focuses on optimizing a particular property of the selected proteins and works by successive selection of proteins from an ordered list and exclusion of all neighbors of each selected protein. The other algorithm aims at maximizing the size of the selected set and works by successive thinning out of clusters of similar proteins. Both algorithms are generally applicable to other data bases in which criteria of similarity can be defined and relate to problems in graph theory. The largest nonredundant set extracted from the current release of the Protein Data Bank has 155 protein chains. In this set, no two proteins have sequence similarity higher than a certain cutoff (30% identical residues for aligned subsequences longer than 80 residues), yet all structurally unique protein families are represented. Periodically updated lists of representative data sets are available by electronic mail from the file server "netserv @ embl-heidelberg.de." The selection may be useful in statistical approaches to protein folding as well as in the analysis and documentation of the known spectrum of three-dimensional protein structures. [less ▲]

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See detailLes polarisations de Vergne dans une algèbre de Lie exponentielle
Molitor-Braun, Carine UL

in Travaux Mathématiques (1992), 4

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See detailReview of: D. Birch. The Language of Drama
Weber, Jean-Jacques UL

in BELL. Belgian Journal of English Language and Literatures (1992), 1

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See detailAnalysis of Subspace Fitting and ML Techniques for Parameter Estimation from Sensor Array Data
Ottersten, Björn UL; Viberg, M.; Kailath, T.

in IEEE Transactions on Signal Processing (1992), SP-40

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See detailSchottky Contacts on n-In0.53Ga0.47As with Enhanced Barriers by Counter-Doped Interfacial Layers,
Kordoš, P.; Marso, Michel UL; Meyer, R. et al

in IEEE Transactions on Electron Devices (1992), 39(1992), 1970-1972

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