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See detailRbt (Rabo torcido), a new mouse skeletal mutation involved in anteroposterior patterning of the axial skeleton, maps close to the Ts (tail-short) locus and distal to the Sox9 locus on chromosome 11.
Hustert, E.; Scherer, G.; Olowson, M. et al

in Mammalian Genome (1996), 7(12), 881-5

Rbt (Rabo torcido) is a new semidominant mouse mutant with a variety of skeletal abnormalities. Heterozygous Rbt mutants display homeotic anteroposterior patterning problems along the axial skeleton that ... [more ▼]

Rbt (Rabo torcido) is a new semidominant mouse mutant with a variety of skeletal abnormalities. Heterozygous Rbt mutants display homeotic anteroposterior patterning problems along the axial skeleton that resemble Polycomb group and trithorax gene mutations. In addition, the Rbt mutant displays strong similarities to the phenotype observed in Ts (Tail-short), indicating also a homeotically transformed phenotype in these mice. We have mapped the Rbt locus to an interval of approximately 6 cM on mouse Chromosome (Chr) 11 between microsatellite markers D11Mit128 and D11Mit103. The Ts locus was mapped within a shorter interval of approximately 3 cM between D11Mit128 and D11Mit203. This indicates that Rbt and Ts may be allelic mutations. Sox9, the human homolog of which is responsible for the skeletal malformation syndrome campomelic dysplasia, was mapped proximal to D11Mit128. It is, therefore, unlikely that Ts and Rbt are mouse models for this human skeletal disorder. [less ▲]

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See detailA role for mel-18, a Polycomb group-related vertebrate gene, during theanteroposterior specification of the axial skeleton.
Akasaka, T.; Kanno, M.; Balling, Rudi UL et al

in Development (1996), 122(5), 1513-22

Segment identity in both invertebrates and vertebrates is conferred by spatially restricted distribution of homeotic gene products. In Drosophila, the expression of Homeobox genes during embryogenesis is ... [more ▼]

Segment identity in both invertebrates and vertebrates is conferred by spatially restricted distribution of homeotic gene products. In Drosophila, the expression of Homeobox genes during embryogenesis is initially induced by segmentation gene products and then maintained by Polycomb group and Trithorax group gene products. Polycomb group gene homologs are conserved in vertebrates. Murine mel-18 and closely related bmi-1 are homologous to posterior sex combs and suppressor two of zeste. Mel-18 protein mediates a transcriptional repression via direct binding to specific DNA sequences. To gain further insight into the function of Mel-18, we have inactivated the mel-18 locus by homologous recombination. Mice lacking mel-18 survive to birth and die around 4 weeks after birth after exhibiting strong growth retardation. Similar to the Drosophila posterior sex combs mutant, posterior transformations of the axial skeleton were reproducibly observed in mel-18 mutants. The homeotic transformations were correlated with ectopic expression of Homeobox cluster genes along the anteroposterior axis in the developing paraxial mesoderm. Surprisingly, mel-18-deficient phenotypes are reminiscent of bmi-1 mutants. These results indicate that the vertebrate Polycomb group genes mel-18 and bmi-1, like Drosophila Polycomb group gene products, might play a crucial role in maintaining the silent state of Homeobox gene expression during paraxial mesoderm development. [less ▲]

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See detailApproximate spectral functions in thermal field theory
Henning, P. A.; Polyatchenko, E.; Schilling, Tanja UL et al

in Physical Review. D, Particles and Fields (1996), 54(5239), 1-5

Causality requires that the ~anti!commutator of two interacting field operators vanishes for spacelike coordinate differences. This implies that the Fourier transform of the spectral function of this ... [more ▼]

Causality requires that the ~anti!commutator of two interacting field operators vanishes for spacelike coordinate differences. This implies that the Fourier transform of the spectral function of this quantum field should vanish in the spacelike domain. We find that this requirement imposes some constraints on the use of resummed propagators in high temperature gauge theory. [less ▲]

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See detailDewey in Europe: A Case-Study on the International Dimensions of the Turn-of-the-Century Educational Reform.
Biesta, Gert UL; Miedema, S.

in American Journal of Education (1996), 105(1), 1-26

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See detailSelegiline stimulates biosynthesis of cytokines interleukin-1 beta and interleukin-6.
Wilfried, K.; Muller, T.; Krüger, Rejko UL et al

in Neuroreport (1996), 7(18), 2847-8

Several lines of evidence indicate an immune-mediated pathophysiology of Parkinson's disease (PD) and Alzheimer's disease (AD). In clinical studies the monoamine oxidase-B inhibitor Selegiline appears to ... [more ▼]

Several lines of evidence indicate an immune-mediated pathophysiology of Parkinson's disease (PD) and Alzheimer's disease (AD). In clinical studies the monoamine oxidase-B inhibitor Selegiline appears to slow the progression of neurological deficits in PD and the cognitive decline in AD. The immune response to bacterial or viral infection and in chronic inflammatory processes is stimulated by an increased synthesis of the cytokines interleukin-1 beta (IL-1 beta) and subsequently interleukin-6 (IL-6). We investigated the influence of Selegiline on the synthesis of IL-1 beta and IL-6 in peripheral blood mononuclear cells (PBMC) from healthy blood donors cultured with or without Selegiline (10(-8)M, 10(-9)M or 10(-10)M) in a humidified atmosphere (7% CO2). Treatment of cultured PBMC with Selegiline significantly increased synthesis of both cytokines. The effect of Selegiline on cytokine biosynthesis may contribute to its putative neuroprotective properties. [less ▲]

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See detailPropagation Delay Estimation in Asynchronous Direct-Sequence Code-Division Multiple Access Systems
Ström, Erik G.; Parkvall, Stefan; Miller, Scott L. et al

in IEEE Transactions on Communications (1996), 44(1), 8493

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See detailBioinformatics and the discovery of gene function
Casari, G.; Daruvar, Dea; Sander, C. et al

in Trends in Genetics (1996), 128(7), 244-245

Scientific history was made in completing the yeast genuine sequence, yet its 13 Mb are a mere starting point. Two challenges loom large: to decipher the function of all genes and to describe the workings ... [more ▼]

Scientific history was made in completing the yeast genuine sequence, yet its 13 Mb are a mere starting point. Two challenges loom large: to decipher the function of all genes and to describe the workings of the eukaryotic cell in full molecular detail. A combination of experimental and theoretical approaches will be brought to bear on these challenges. What will be next in yeast genome analysis from the point of view of bioinformatics? [less ▲]

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See detailModèles pour le contenu des tâches d’assemblage de faces géométriques et difficulté des items
Dickes, Paul; Houssemand, Claude UL; Reuter, Monique

in Psychologie Française (1996), 41

Deux modèles théoriques pour décrire l'univers des configurations à quatre faces et deux couleurs dans une tâche d'assemblage de type Kohs sont proposés. Le premier se base sur les relations qui existent ... [more ▼]

Deux modèles théoriques pour décrire l'univers des configurations à quatre faces et deux couleurs dans une tâche d'assemblage de type Kohs sont proposés. Le premier se base sur les relations qui existent entre les faces et le second sur les caractéristiques distinctives entre les items. L'isomorphisme entre les deux modèles est souligné. Le modèle relationnel explique 49% et le modèle en saillance 42% de la variance de la difficulté des 1296 items de l'univers, déterminée par une recherche empirique avec des enfants et des étudiants. L'utilité des deux modèles est discutée. [less ▲]

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See detailTidal Gravity Measurements in Southeast Asia
Melchior, Paul; Francis, Olivier UL; Ducarme, Bernard

in Marées Terrestres Bulletin d'Informations (1996), (125), 9493-9507

Detailed reference viewed: 58 (1 UL)
See detailJugend und Politik: Politisches Interesse, Institutionenvertrauen, Wertorientierungen und Partizipationsbereitschaften
Willems, Helmut UL; Gille, Martina; Krüger, Winfried et al

in DISKURS : Studien zu Kindheit, Jugend, Familie und Gesellschaft (1996), 6(1), 62-70

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See detailDer Reminiszenzfragebogen: Skalenkonstruktion und teststatistische Überprüfung.
Mayer, Anne-Kathrin; Filipp, Sigrun-Heide; Ferring, Dieter UL

in Focus Diagnostica (1996), 42(2)

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See detailBespreking van S. Roegholt. Meerperspectivisch Onderwijs.
Biesta, Gert UL

in Comenius (1996), 16

Detailed reference viewed: 52 (0 UL)
See detailJugend und Politik
Willems, Helmut UL; Gille, Martina

in Jugendhilfe Report (1996), (2), 35-35

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See detailExpression of the plasma membrane Ca2+-ATPase in myogenic cells.
Hammes, A.; Oberdorf-Maass, S.; Jenatschke, S. et al

in The Journal of biological chemistry (1996), 271(48), 30816-22

To study the physiological function of the plasma membrane calmodulin-dependent calcium ATPase (PMCA) in intact cells, L6 myogenic cell lines stably overexpressing the human PMCA isoform 4CI (= human PMCA ... [more ▼]

To study the physiological function of the plasma membrane calmodulin-dependent calcium ATPase (PMCA) in intact cells, L6 myogenic cell lines stably overexpressing the human PMCA isoform 4CI (= human PMCA isoform 4b) were generated. Several independent L6 clones and controls stably transfected with the empty expression vector were analyzed in detail. The resting cytosolic calcium level in hPMCA4CI-overexpressing muscle cells (measured by the Fura-2 method) was significantly reduced by 20-30% compared with controls. This was shown in a cytosolic window of 1322 single cells (p < 0.01). Furthermore, the differentiation process of these cells was remarkably accelerated compared with control myoblasts and parental nontransfected L6 cells as assessed by multinucleated myotube formation and creatine phosphokinase activity elevation. After 4 and 6 days of differentiation, PMCA-overexpressing L6 cells from four independent clones displayed a 3- and 4-fold higher creatine phosphokinase activity compared with controls (n = 5, p < 0.02). These results may extend the concept of the function of the PMCA from simple prevention of calcium overload to an active involvement in intracellular calcium regulation with potentially important consequences for cellular functions. [less ▲]

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See detailLa convertibilité des monnaies en Afrique Subsaharienne hors zone franc
Bourgain, Arnaud UL

in Mondes en Développement (1996), 24(94), 71-84

Detailed reference viewed: 65 (2 UL)
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See detail[Beta blockers in chronic heart failure. Clinical position on the topic].
Dominiak, P.; Erdmann, E.; Kreuzer, H. et al

in Der Internist (1996), 37(12), 1274-81279

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See detailDS-CDMA Synchronization in Time-Varying Fading Channels
Ström, Erik G.; Parkvall, Stefan; Miller, Scott L. et al

in IEEE Journal on Selected Areas In Communications (1996), 14(8), 16361642

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See detailVeränderungsmuster im Bewältigungsverhalten von Krebspatienten und Korrelate von Veränderungen: Ein personorientierter Ansatz.
Ferring, Dieter UL; Sommer, C.; Filipp, Sigrun-Heide

in Zeitschrift für Gesundheitspsychologie (1996), 4(4)

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See detailGeneCrunch and Europort, examples for Hierarchical Supercomputing at Silicon Graphics
Schneider, Reinhard UL; Schlenkrich, M.

in WWW-publication (1996)

The SGI POWER CHALLENGEarray TM represents a hierarchical supercomputer because it combines distributed and shared memory technology. We present two projects, Europort and GeneCrunch, that took advantage ... [more ▼]

The SGI POWER CHALLENGEarray TM represents a hierarchical supercomputer because it combines distributed and shared memory technology. We present two projects, Europort and GeneCrunch, that took advantage of such a configuration. In Europort we performed scalability demonstrations up to 64 processors with applications relevant to the chemical and pharmaceutical industries. GeneCrunch, a project in bioinformatics, performed an analysis of the whole yeast genome using the software system GeneQuiz. This project showcased the future demands of HPC in pharmaceutical industries in tackling analysis of fast growing volumes of sequence information. GeneQuiz, an automated software system for large-scale genome analysis developed at the EMBL /EBI , aims at predicting the function of new genes by using an automated, rigorous, rule-based system to process the results of sequence analysis and database searches to build databases of annotations and predictions. In GeneCrunch more than 6,000 proteins from baker's yeast, for which the complete genomic sequence was completed in 1996, were analyzed on a SGI® POWER CHALLENGEarray with 64 processors (R8000® at 90MHz) in three days rather than the seven months predicted for a normal workstation [less ▲]

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See detailInterkultureller Fremdsprachenunterricht und die Heterogenität von Kulturen
Hu, Adelheid UL

in Zeitschrift für Interkulturellen Fremdsprachenunterricht (1996), 1(3), 16

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See detailResponsivity Enhancement of InGaAs Based MSM Photodetectors Using 2DEG Layer Sequence and Semitransparent Electrodes
Horstmann, M.; Marso, Michel UL; Muttersbach, J. et al

in Electronics Letters (1996), 32

The optoelectronic behaviour of InGaAs based metalsemiconductor-metal photodetectors with semitransparent electrodes is investigated. The devices with 50 x 50 um2 area and interdigitated electrodes with ... [more ▼]

The optoelectronic behaviour of InGaAs based metalsemiconductor-metal photodetectors with semitransparent electrodes is investigated. The devices with 50 x 50 um2 area and interdigitated electrodes with 2um finger-spacing and finger-width exhibit a dark current density less than 10pA/um2, a breakdown voltage of 45V and a saturation capacitance of 30fF. A DC responsivity of 0.61A/W and a –3dB bandwidth of 8.5GHz were achieved. The electric potential distribution is modified by a 2DEG inserted in the layer structure leading, to improved bandwidth. [less ▲]

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See detailExpression of avian Pax1 and Pax9 is intrinsically regulated in the pharyngeal endoderm, but depends on environmental influences in the paraxial mesoderm.
Muller, Tim UL; Ebensperger, C.; Neubuser, A. et al

in Developmental Biology (1996), 178(2), 403-17

Pax1 and Pax9 represent a subfamily of paired-box-containing genes. In vertebrates, Pax1 and Pax9 transcripts have been found specifically in mesodermal tissues and the pharyngeal endoderm. Pax1 ... [more ▼]

Pax1 and Pax9 represent a subfamily of paired-box-containing genes. In vertebrates, Pax1 and Pax9 transcripts have been found specifically in mesodermal tissues and the pharyngeal endoderm. Pax1 expression in the sclerotomes has been shown to be indispensable for proper formation of the axial skeleton, but expression of Pax1 in the endoderm has not been studied in detail. We have cloned the chick homologue of the murine Pax9 gene. Our results show that transcripts of Pax1 and Pax9 are first detectable in the prospective foregut endoderm of headfold-stage avian embryos. Endodermal expression correlates with the highly proliferative zones of the folding foregut and evaginating pharyngeal pouches. In later stages, Pax1 and Pax9 are expressed in overlapping but distinct patterns within the developing sclerotomes and limb buds. From grafting experiments we conclude that activation of pharyngeal Pax1 and Pax9 expression is an intrinsic property of the endoderm, not requiring midline structures or head mesoderm. In contrast, notochord is required to induce Pax1 in competent sclerotomes. Here we show that in vitro there is a cranio-caudal gradient of inductive capacity in the notochord. This coincides with the graded expression of Pax1 and Pax9 along the cranio-caudal axis in 2- to 3-day-old embryos. Furthermore, paraxial head mesoderm shows no competence to express Pax1. Finally, in vitro we find counteracting influences on notochord signaling by lateral tissues (lateral plate, intermediate mesoderm), leading to an inhibition of Sonic hedgehog (Shh) expression in notochord and floor plate, as well as Pax1 and Pax9 expression in sclerotomes. Taken together, our results demonstrate that different mechanisms regulate expression of Pax1 and Pax9 in foregut and sclerotome, but suggest a common function for both genes in the two tissues that is promoting proliferation and preventing fusion of neighboring blastemas. [less ▲]

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See detailPax genes and skeletal development.
Balling, Rudi UL; Helwig, U.; Nadeau, J. et al

in Annals of the New York Academy of Sciences (1996), 785

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See detail«Les mille visages de Gilles Deleuze»
Roelens, Nathalie UL

in Restant (1996)

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See detailComparative use of muscle relaxants and their reversal in three European countries: a survey in France, Germany and Great Britain
Osmer, Christian; Vögele, Claus UL; Zickmann, Bernfried et al

in European Journal of Anaesthesiology (1996), 13

A survey was conducted among British, French and German anaesthetists to evaluate possible national differences in the peri-operative use of muscle relaxants and their reversal agents. The same non ... [more ▼]

A survey was conducted among British, French and German anaesthetists to evaluate possible national differences in the peri-operative use of muscle relaxants and their reversal agents. The same non-depolarizing relaxants are used in all three countries, with the exception of d-tubocurarine, which is only available in Great Britain, and alcuronium which is mainly used in Germany. The French anaesthetists seem to use significantly less succinylcholine than their peers in Great Britain or Germany for both elective and emergency intubation. Monitoring of neuromuscular blockade still relies mainly on "clinical judgement'. Reversal of non-depolarizing muscle relaxants is performed routinely in Great Britain, while a substantial number of French anaesthetists avoid the use of a reversal. Dose regimes for neostigmine vary largely, with German anaesthetists administering the lowest, and British anaesthetists administering the highest doses. Side effects of reversal agents are reported by colleagues from all three countries in too high a percentage to justify uncritical administration of these drugs. In Germany there seems to be a noteworthy lack of recovery facilities. [less ▲]

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See detailDas Verhältnis Jugendlicher und junger Erwachsener zur Politik: Normalisierung oder Krisenentwicklung?
Willems, Helmut UL; Gille, Martina; Krüger, Winfried et al

in Aus Politik und Zeitgeschichte (1996), (19), 3-17

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See detailMessung des Selbstwertgefühls: Befunde zu Reliabilität, Validität und Stabilität der Rosenberg-Skala.
Ferring, Dieter UL; Filipp, Sigrun-Heide

in Focus Diagnostica (1996), 42(3)

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See detailWirtschaftsverkehr. Stadtlogistik zum öffentlichen Thema machen!
Hatzfeld, Ulrich; Hesse, Markus UL

in Informationen zur Raumentwicklung (1996), (7/8), 417-436

Detailed reference viewed: 113 (0 UL)
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See detailMobilisierungseffekte und Eskalationsprozesse: Entwicklung und Diffusion der kollektiven Gewalt gegen Fremde
Willems, Helmut UL

in Berliner Debatte INITIAL (1996), 7. Jg(1), 34-43

Detailed reference viewed: 100 (0 UL)
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See detailThe HSSP database of protein structure sequence alignments
Schneider, Reinhard UL; Sander, C.

in Nucleic Acids Research (1996), 24(1), 201-205

HSSP is a derived database merging structural three dimensional (3-D) and sequence one dimensional (1-D) information. For each protein of known 3-D structure from the Protein Data Bank (PDB), the database ... [more ▼]

HSSP is a derived database merging structural three dimensional (3-D) and sequence one dimensional (1-D) information. For each protein of known 3-D structure from the Protein Data Bank (PDB), the database has a multiple sequence alignment of all available homologues and a sequence profile characteristic of the family. The list of homologues is the result of a database search in Swissprot using a position-weighted dynamic programming method for sequence profile alignment (MaxHom). The database is updated frequently. The listed homologues are very likely to have the same 3-D structure as the PDB protein to which they have been aligned. As a result, the database is not only a database of aligned sequence families, but also a database of implied secondary and tertiary structures covering 27% of all Swissprotstored sequences. [less ▲]

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See detailGeneCrunch: Experiences on the SGI POWER CHALLENGEarray with Bioinformatics applications
Schneider, Reinhard UL; Casari, G.; Daruvar, A. et al

in Supercomputer 96 : Anwendungen, Architekturen, Trends (1996)

Analyzing genomic data is a computationally intensive and complicated process in which scientists must typically choose among multiple databases and analysis methods and make expert judgements inspecting ... [more ▼]

Analyzing genomic data is a computationally intensive and complicated process in which scientists must typically choose among multiple databases and analysis methods and make expert judgements inspecting multiple results. GeneQuiz, an automated software system for large scale genome analysis developed at the EMBL/EBI, tackles this problem by using an automated, rigorous, rule-based system to select among the results of sequence analysis and database searches, builds informative annotation and aims at predicting the function of new genes. In a demonstration project more than 6000 proteins from the Baker’s yeast, for which the complete genomic sequence was completed in 1996, were analyzed on a Silicon Graphics POWERCHALLENGEarray with 64 processors (R8000 @90 MHz) so that the analysis could be completed in 3 days. The results of the analysis were published on two web servers as they were computed. [less ▲]

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See detailA reading of Troubadour insult songs: the Comunals cycle
Leglu, Catherine UL

in Reading Medieval Studies (1996), XXII

An analysis of a cycle of aggressive songs by troubadours.

Detailed reference viewed: 71 (1 UL)
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See detailNotice «Hervé Guibert»
Roelens, Nathalie UL

in Voir (1996)

Detailed reference viewed: 67 (1 UL)
See detailEin Brief über den »Phöbus«. Adam Müller an den Verleger Reimer, 23.1.1801
Amann, Wilhelm UL

in Brandenburger Kleist-Blätter (1996), 6

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See detailTidal loading in south western Europe: A test area
Francis, Olivier UL; Melchior, P.

in Geophysical Research Letters (1996), 23(17), 2251-2254

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See detailComparison of recent ocean tide models using ground-based tidal gravity measurements
Melchior, Paul; Francis, Olivier UL

in Marine Geodesy (1996), 19(4), 291-330

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See detail«Egotisme et autodérision chez Stendhal. Je tombe donc je suis»
Roelens, Nathalie UL

in Dix-neuf/Vingt, Revue de littérature moderne (1996)

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See detailPax genes and sclerotome induction
Balling, Rudi UL; Neubüser, A; Christ, B

in Seminars in Cell & Developmental Biology (1996), (7), 129-136

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See detailL’avis 1/94 de la C.J.C.E. et ses implications sur l’ordre juridique communautaire
Neframi, Eleftheria UL

in Revue hellénique de droit européen (1996)

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See detailThe Impact of Timing Errors on the Performance of Linear DS-CDMA Receivers
Parkvall, Stefan; Ström, Erik G.; Ottersten, Björn UL

in IEEE Journal on Selected Areas In Communications (1996), 14(8), 16601668

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See detailThe dirac oscillator of arbitrary spin
del Sol Mesa, Antonio UL

in Journal of Physics: A Mathematical and General (1996)

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See detail«Orphée à l'écran: un défi représentatif (avec Sabine Hillen)»
Roelens, Nathalie UL

in Canadian Review of Comparative Literature = Revue Canadienne de Littérature Comparée (1996)

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See detailSur une conjecture sur les points de torsion rationnels des Jacobiennes de courbes
Leprévost, Franck UL

in Journal für die Reine und Angewandte Mathematik (1996), 473

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See detailVon Knick- und Ringelschwänzen - Mäuse als Modellorganismus
Balling, Rudi UL

in Forschung-Mitteilungen der DFG (1996), (2), 13-14

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See detailAn Experiment for Truly Parallel Logic Programming
Efthivoulidis, G.; Vlassis, Nikos UL; Tsanakas, P. et al

in Journal of Intelligent and Robotic Systems (1996), 16(2), 169-184

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See detailPax1 is expressed during development of the thymus epithelium and is required for normal T-cell maturation.
Wallin, J.; Eibel, H.; Neubuser, A. et al

in Development (1996), 122(1), 23-30

Pax1 is a transcriptional regulatory protein expressed during mouse embryogenesis and has been shown to have an important function in vertebral column development. Expression of Pax1 mRNA in the embryonic ... [more ▼]

Pax1 is a transcriptional regulatory protein expressed during mouse embryogenesis and has been shown to have an important function in vertebral column development. Expression of Pax1 mRNA in the embryonic thymus has been reported previously. Here we show that Pax1 protein expression in thymic epithelial cells can be detected throughout thymic development and in the adult. Expression starts in the early endodermal epithelium lining the foregut region and includes the epithelium of the third pharyngeal pouch, a structure giving rise to part of the thymus epithelium. In early stages of thymus development a large proportion of thymus cells expresses Pax1. With increasing age, the proportion of Pax1-expressing cells is reduced and in the adult mouse only a small fraction of cortical thymic stromal cells retains strong Pax1 expression. Expression of Pax1 in thymus epithelium is necessary for establishing the thymus microenvironment required for normal T cell maturation. Mutations in the Pax-1 gene in undulated mice affect not only the total size of the thymus but also the maturation of thymocytes. The number of thymocytes is reduced about 2- to 5-fold, affecting mainly the CD4+8+ immature and CD4+ mature thymocyte subsets. The expression levels of major thymocyte surface markers remains unchanged with the exception of Thy-1 which was found to be expressed at 3- to 4-fold higher levels. [less ▲]

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See detailReview article of John E. Tiles, John Dewey.
Biesta, Gert UL

in Studies in Philosophy & Education (1996), 15

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See detailEstimation of Nominal Direction of Arrival and Angular Spread Using an Array of Sensors
Trump, T.; Ottersten, Björn UL

in Signal Processing (1996), 50(1-2), 5769

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See detailMaximum Likelihood Array Processing for Stochastic Coherent Sources
Stoica, Petre; Ottersten, Björn UL; Viberg, Mats et al

in IEEE Transactions on Signal Processing (1996), 44

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See detailSzLB – Skala zur Lebensbewertung (SLB).
Ferring, Dieter UL; Filipp, Sigrun-Heide; Schmidt, Katharina

in Zeitschrift für Differentielle und Diagnostische Psychologie (1996), 17(3)

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See detailEditorial
Tröhler, Daniel UL

in Neue Pestalozzi-Blätter (1996), 2(2), 1-1

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See detailDie Polizei im Umgang mit Fremden - Problemlagen, Belastungssituationen und Übergriffe
Bornewasser, Manfred; Eckert, Roland; Willems, Helmut UL

in Fremdenfeindlichkeit in der Polizei? Schriftenreihe der Polizei-Führungsakademie (1996), (1/2), 9-165

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See detailPAX genes and human neural tube defects: an amino acid substitution in PAX1 in a patient with spina bifida.
Hol, F. A.; Geurds, M. P.; Chatkupt, S. et al

in Journal of Medical Genetics (1996), 33(8), 655-60

From studies in the mouse and from the clinical and molecular analysis of patients with type 1 Waardenburg syndrome, particular members of the PAX gene family are suspected factors in the aetiology of ... [more ▼]

From studies in the mouse and from the clinical and molecular analysis of patients with type 1 Waardenburg syndrome, particular members of the PAX gene family are suspected factors in the aetiology of human neural tube defects (NTD). To investigate the role of PAX1, PAX3, PAX7, and PAX9, allelic association studies were performed in 79 sporadic and 38 familial NTD patients from the Dutch population. Sequence variation was studied by SSC analysis of the paired domain regions of the PAX1, PAX7, and PAX9 genes and of the complete PAX3 gene. In one patient with spina bifida, a mutation in the PAX1 gene was detected changing the conserved amino acid Gln to His at position 42 in the paired domain of the protein. The mutation was inherited through the maternal line from the unaffected grandmother and was not detected in 300 controls. In the PAX3 gene, variation was detected at several sites including a Thr/Lys amino acid substitution in exon 6. All alleles were present among patients and controls in about the same frequencies. However, an increased frequency of the rare allele of a silent polymorphism in exon 2 was found in NTD patients, but no significant association was observed (p = 0.06). No sequence variation was observed in the paired domain of the PAX7 and PAX9 genes. Our findings so far do not support a major role of the PAX genes examined in the aetiology of NTD. However, the detection of a mutation in PAX1 suggests that, in principle, this gene can act as a risk factor for human NTD. [less ▲]

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See detailBespreking van Max Velthuis, Kikker is verliefd.
Biesta, Gert UL

in Comenius (1996), 16

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See detailDagmar Schifferli: Anna Pestalozzi-Schulthess. Ihr Leben mit Heinrich Pestalozzi.
Tröhler, Daniel UL

in Bulletin der Schweizerischen Gesellschaft für die Erforschung des 18. Jahrhunderts (1996), 9

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See detailCytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor
Kischkel, F. C.; Hellbardt, S.; Behrmann, Iris UL et al

in EMBO Journal (1996), 14(22), 5579-88

APO-1 (Fas/CD95), a member of the tumor necrosis factor receptor superfamily, induces apoptosis upon receptor oligomerization. In a search to identify intracellular signaling molecules coupling to ... [more ▼]

APO-1 (Fas/CD95), a member of the tumor necrosis factor receptor superfamily, induces apoptosis upon receptor oligomerization. In a search to identify intracellular signaling molecules coupling to oligomerized APO-1, several cytotoxicity-dependent APO-1-associated proteins (CAP) were immunoprecipitated from the apoptosis-sensitive human leukemic T cell line HUT78 and the lymphoblastoid B cell line SKW6.4. CAP1-3 (27-29 kDa) and CAP4 (55 kDa), instantly detectable after the crosslinking of APO-1, were associated only with aggregated (the signaling form of APO-1) and not with monomeric APO-1. CAP1 and CAP2 were identified as serine phosphorylated MORT1/FADD. The association of CAP1-4 with APO-1 was not observed with C-terminally truncated non-signaling APO-1. In addition, CAP1 and CAP2 did not associate with an APO-1 cytoplasmic tail carrying the lprcg amino acid replacement. Moreover, no APO-1-CAP association was found in the APO-1+, anti-APO-1-resistant pre-B cell line Boe. Our data suggest that in vivo CAP1-4 are the APO-1 apoptosis-transducing molecules. [less ▲]

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See detailNeuropeptides and their receptors in the environment of nociceptors: Where and why?
Schmidt, Robert; Hanesch, Ulrike UL

in Neuropeptides (1996)

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See detailThe Relative Abundance of Brotheas amazonicus (Chactidae, Scorpiones) in Different Habitat Types of a Central Amazon Rainforest
Hoefer, Hubert; Wollscheid-Lengeling, Evi UL; Gasnier, Thierry

in Journal of Arachnology (1996), 24(1), 34-38

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See detailBrownian motion and the formation of singularities in the heat flow for harmonic maps
Thalmaier, Anton UL

in Probability Theory and Related Fields (1996), 105(3), 335-367

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See detailUmweltmanagement. Neue Ansätze durch EG-Öko-Audit und DIN-ISO 14001.
Ankele, Kathrin; Hesse, Markus UL

in Internationales Verkehrswesen (1996), 48(9), 39-44

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See detailLeben auf der Rückseite der Medaille. Lebensbedingungen im Stadtteil Gare. Forschungsbericht
Baltes-Löhr, Christel UL

in Forum für Politik, Gesellschaft und Kultur in Luxemburg (1996), (172), 11-15

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See detailNotice «Vladimir Nabokov»
Roelens, Nathalie UL

in Voir (1996)

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See detailOn some solutions of the Dirac equation
del Sol Mesa, Antonio UL

in Journal of Physics: A Mathematical and General (1996)

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See detailEstrogen effects in the heart.
Pelzer, T.; Shamim, A.; Neyses, Ludwig UL

in Molecular and Cellular Biochemistry (1996), 160-161

Gender specific differences in cardiovascular disease are largely mediated by sex hormones. The use of estrogens significantly reduces the overall incidence of heart disease in postmenopausal women ... [more ▼]

Gender specific differences in cardiovascular disease are largely mediated by sex hormones. The use of estrogens significantly reduces the overall incidence of heart disease in postmenopausal women. Beneficial effects of estrogens on plasma lipoprotein levels are clearly established. However, these do not explain the magnitude of risk reduction seen in clinical studies. Thus additional and currently unknown functions of estrogens must be operative. Elucidation of the exact estrogen action in the heart will have important implications in the treatment of cardiovascular disease. It will probably enhance the therapeutic repertoire in treating heart disease, the most common cause of death in industrialized countries. We will review the current understanding of the function of estrogens in the heart and discuss potential strategies on how to apply these data to clinical practice. [less ▲]

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See detailDesign and analysis of dynamic leader election protocols in broadcast networks
Brunekreef, J. J.; Katoen, J.-P.; Koymans, R. et al

in Distributed Computing (1996), 9(4), 157-171

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See detailDivergent sequence motifs correlated with the substrate specificity of (methyl)malonyl-CoA:acyl carrier protein transacylase domains in modular polyketide synthases.
Haydock, S. F.; Aparicio, J. F.; König, Ariane UL et al

in FEBS Letters (1995), 374(2), 246-248

The amino acid sequences of a large number of polyketide synthase domains that catalyse the transacylation of either methylmalonyl-CoA or malonyl-CoA onto acyl carrier protein (ACP) have been compared ... [more ▼]

The amino acid sequences of a large number of polyketide synthase domains that catalyse the transacylation of either methylmalonyl-CoA or malonyl-CoA onto acyl carrier protein (ACP) have been compared. Regions were identified in which the acyltransferase sequences diverged according to whether they were specific for malonyl-CoA or methylmalonyl-CoA. These differences are sufficiently clear to allow unambiguous assignment of newly-sequenced acyltransferase domains in modular polyketide synthases. Comparison with the recently-determined structure of the malonyltransferase from Escherichia coli fatty acid synthase showed that the divergent region thus identified lies near the acyltransferase active site, though not close enough to make direct contact with bound substrate. [less ▲]

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See detailDie Pädagogik des Fin de Siècle - een impressie
Biesta, Gert UL

in Nieuwsbrief BNVGOO (1995), 4

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See detailIdentiteit, cultuur en opvoeding. Impressies van het vierde congres van het International Network of Philosophers of Education
Biesta, Gert UL

in Pedagogisch Tijdschrift: Forum voor Opvoedkunde (1995), 20(1), 57-64

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See detailThe biosynthetic cluster for the polyketide immunosuppressant rapamycin
Schwecke, T.; Aparicio, J. F.; Molnár, I. et al

in Proceedings of the National Academy of Sciences of the United States of America (1995), 92(17), 7839-7843

The macrocyclic polyketides rapamycin and FK506 are potent immunosuppressants that prevent T-cell proliferation through specific binding to intracellular protein receptors (immunophilins). The cloning and ... [more ▼]

The macrocyclic polyketides rapamycin and FK506 are potent immunosuppressants that prevent T-cell proliferation through specific binding to intracellular protein receptors (immunophilins). The cloning and specific alteration of the biosynthetic genes for these polyketides might allow the biosynthesis of clinically valuable analogues. We report here that three clustered polyketide synthase genes responsible for rapamycin biosynthesis in Streptomyces hygroscopicus together encode 14 homologous sets of enzyme activities (modules), each catalyzing a specific round of chain elongation. An adjacent gene encodes a pipecolate-incorporating enzyme, which completes the macrocycle. The total of 70 constituent active sites makes this the most complex multienzyme system identified so far. The DNA region sequenced (107.3 kbp) contains 24 additional open reading frames, some of which code for proteins governing other key steps in rapamycin biosynthesis. [less ▲]

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See detailCharacterization of the ordered weighted averaging operators
Fodor, Janos; Marichal, Jean-Luc UL; Roubens, Marc

in IEEE Transactions on Fuzzy Systems (1995), 3(2), 236-240

This paper deals with the characterization of two classes of monotonic and neutral (MN) aggregation operators. The first class corresponds to (MN) aggregators which are stable for the same positive linear ... [more ▼]

This paper deals with the characterization of two classes of monotonic and neutral (MN) aggregation operators. The first class corresponds to (MN) aggregators which are stable for the same positive linear transformations and presents the ordered linkage property. The second class deals with (MN)-idempotent aggregators which are stable for positive linear transformations with the same unit, independent zeroes and ordered values. These two classes correspond to the weighted ordered averaging operator (OWA) introduced by Yager in 1988. It is also shown that the OWA aggregator can be expressed as a Choquet integral. [less ▲]

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See detailEin runder Tisch für den Wirtschaftsverkehr. Prozessuale Planungs- und Kommunikationsformen
Hesse, Markus UL

in DISP Dokumente und Informationen zur Schweizerischen Orts-, Regional- und Landesplanung (1995), (121), 19-24

Erfahrungsbericht vom Einsatz prozessualer bzw. kommunikativer Planungsformen in einem tendenziell nicht-kommunikativen Milieu.

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See detailOn the institutional determinants of economic development. Lessons from a stochastic neoclassical growth model
Klump, Rainer UL

in Jahrbuch für Wirtschaftswissenschaften / Review of Economics (1995)

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See detailCharacterization and developmental expression of Pax9, a paired-box-containing gene related to Pax1.
Neubuser, A.; Koseki, H.; Balling, Rudi UL

in Developmental Biology (1995), 170(2), 701-16

Pax9, a recently identified mouse paired-box-containing gene, is highly homologous to Pax1 and belongs to the same subfamily as Pax1, Hup48, PAX9, and pox meso. Two overlapping cDNA clones spanning the ... [more ▼]

Pax9, a recently identified mouse paired-box-containing gene, is highly homologous to Pax1 and belongs to the same subfamily as Pax1, Hup48, PAX9, and pox meso. Two overlapping cDNA clones spanning the entire coding region of Pax9 were isolated and sequenced. A comparison of the Pax1 and -9 protein sequences reveals a high degree of similarity even outside the paired box, while the carboxy-terminus of the two proteins diverges completely. We demonstrate that Pax9 can bind to the e5 sequence from the Drosophila even skipped promoter, which is also recognized by Pax1. We analyzed the expression of Pax9 during embryogenesis of wildtype, Undulated short-tail (Uns), and Danforth's short tail (Sd) mice. In wildtype embryos Pax9 is expressed in the pharyngeal pouches and their derivatives, the developing vertebral column, the tail, the head, and the limbs. Expression of Pax9 is unaffected in Uns embryos, in which the Pax1 gene is deleted, arguing that expression of Pax9 is not dependent on Pax1. The expression of Pax9 is lost in the caudal part of Sd homozygous embryos, suggesting that expression of Pax9 in the vertebral column is dependent on the notochord. These results indicate that both Pax9 and -1 may act in parallel during morphogenesis of the vertebral column. [less ▲]

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See detailStaatsgewalt und Kindsmord: zum sozialphilosophischen Hintergrund von Pestalozzis Schrift: "Über Gesetzgebung und Kindermord" (1780/83)
Tröhler, Daniel UL

in Schweizerische Zeitschrift fur Bildungswissenschaften = Rivista svizzera di scienze dell'educazione = Revue suisse des sciences de l'education (1995), (1), 34-35

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See detailIon Sensitive Field Effect Transistors with Ultrathin Langmuir-Blodgett Membranes
Schöning, M. J.; Sauke, M.; Steffen, A. et al

in Sensors and actuators. B, Chemical (1995), 26-27(1995), 325-328

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See detailStructure of the human APO-1 gene
Behrmann, Iris UL; Walczak, H.; Krammer, P. H.

in European Journal of Immunology (1995), 24(12), 3057-62

APO-1/Fas (CD95) is a type 1 transmembrane protein that belongs to the tumor necrosis factor/nerve growth factor receptor family characterized by cysteine-rich extracellular domains. Cross-linking of APO ... [more ▼]

APO-1/Fas (CD95) is a type 1 transmembrane protein that belongs to the tumor necrosis factor/nerve growth factor receptor family characterized by cysteine-rich extracellular domains. Cross-linking of APO-1 mediates apoptosis in a variety of cells. In the present study we report the isolation and characterization of the human APO-1 gene spanning approximately 25 kb of human chromosome 10. The gene consists of nine exons (25 bp to > 1.44 kb) separated by eight introns (152 bp to approximately 12 kb). The boundaries of exon 2 to 5 encoding the extracellular region do not match the boundaries of the three APO-1 protein subdomains. Exon structure and functional protein domains correspond for exon 6 encoding the transmembrane region and for exon 9 encoding the "death domain". By a polymerase chain reaction-based approach we localized major transcriptional start sites in human spleen cells 77 and 73 nucleotides upstream of the translation initiation codon of the human APO-1 gene. Minor initiation sites were found at positions -128, -111, -91, and -74. The 5' flanking sequence of the human APO-1 gene is GC rich, contains a high number of CpG dinucleotides and lacks a consensus TATA box. Consensus binding sites for the transcription factors Sp1, AP-1, AP-2, GAF, NF-kappa B, and NF-AT were found. The elucidation of the human APO-1 gene structure will facilitate the study of its involvement in various diseases such as in autoimmunity. [less ▲]

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See detailAn Extended Quantum Model for Porous Silicon Formation
Frohnhoff, St; Marso, Michel UL; Berger, M. G. et al

in Journal of the Electrochemical Society (1995), 142(1995), 615-620

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See detailContributions de l’Union européenne à l’intégration régionale en Afrique subsaharienne : quelles spécificités ?
Bourgain, Arnaud UL

in Mondes en Développement (1995), 23(92), 43-56

The aim of this article is to observe the different bearings of the European Union contributions to the economic regional integration in subsaharan Africa. As the European Union is itself a regional ... [more ▼]

The aim of this article is to observe the different bearings of the European Union contributions to the economic regional integration in subsaharan Africa. As the European Union is itself a regional integration, it can be of some help in a debate dominated by the World Bank. The European Union gives more importance to the financement of projects with regional charachteristic than any others partners and doing so gives a full dimension to the support of the European developpement for regional inegration. The support perspectives to regional inegration seem to go towards an important commitment for regional programs, such as the project of budgetary convergence in West Africa. [less ▲]

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See detailErstspracherwerb als Thema des akademischen Unterrichts
Sieburg, Heinz UL

in Germanistik. Publications du Centre Universitaire du Luxembourg. Lettres Allemandes (1995)

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See detail[Molecular adaptation of the heart to hypertension].
Neyses, Ludwig UL; Pelzer, T.

in Zeitschrift fur Kardiologie (1995), 84 Suppl 4

Because myocardial hypertrophy is an independent risk factor for sudden death and cardiac failure, it is important to understand its molecular mechanisms to be able to devise new treatment strategies in ... [more ▼]

Because myocardial hypertrophy is an independent risk factor for sudden death and cardiac failure, it is important to understand its molecular mechanisms to be able to devise new treatment strategies in the future. Stretch is the putative primary stimulus triggering hypertrophy. Further signal transduction steps such as auto- and paracrine secretion of growth factors or transmission via the cytoskeleton are beginning to be unravelled. Subsequent to hypertrophic stimuli some important proteins undergo an isoform switch; questitatively, however, the most important step is an increase in translational capacity for each mRNA. Myocardial specific gene expression is achieved by coordinate interaction of several transcription factors, some of which may be involved in nuclear transmission of hypertrophic signals. One of the genes capable of transmitting hypertrophic signals is the "early growth response gene-1 (Egr-1)". We have also shown that nuclear estrogen receptors act as transcription factors in the myocardium and may therefore be involved in the sex-specific modulation of cardiac hypertrophy. At present, pharmacological interventions aiming at reduction of hypertrophy by interfering with the signal transduction pathway from the membrane to the nucleus are actively being sought. These transduction pathways are composed of a series of proteinkinases which may be amenable to drugs. In the future, gene transfer may become an option for treatment. [less ▲]

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See detailAssignment of the paired box gene Pax1 to rat chromosome 3.
Otsen, M.; Balling, Rudi UL; Den Bieman, M. et al

in Mammalian Genome (1995), 6(9), 666-7

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See detailHormonal induction of an immediate-early gene response in myogenic cell lines--a paradigm for heart growth.
Maass, A.; Grohe, C.; Kubisch, C. et al

in European heart journal (1995), 16 Suppl C

Cardiac hypertrophy is characterized by growth of myocardial cells without proliferation. Many endo- paracrine stimuli such as angiotensin II, endothelin, alpha 1-adrenergic agonists, and insulin have ... [more ▼]

Cardiac hypertrophy is characterized by growth of myocardial cells without proliferation. Many endo- paracrine stimuli such as angiotensin II, endothelin, alpha 1-adrenergic agonists, and insulin have been shown to be able to induce cardiac hypertrophy either in vivo or in vitro. We have used the myoblast model of differentiation and proliferation to determine nuclear signal transduction mechanisms in muscle and (by analogy) cardiac growth. The first nuclear event known to occur when a growth stimulus acts upon a cell is induction of a family of immediate-early genes. Our group focused on the role of one of these genes, the early growth response gene-1 (Egr-1). We have shown that this gene is induced in isolated adult cardiac myocytes in the presence of endothelin. An anti-sense oligonucleotide complementary to the first six codons of the Egr-1 mRNA abolishes the stimulation of protein synthesis induced by endothelin. In the present study we further characterized paracrine growth stimuli in the myogenic cell line Sol8, which was used as a paradigm to further investigate mechanisms of paracrine growth induction. We demonstrated that a variety of candidate endo- paracrine stimuli for the induction of cardiac hypertrophy induced the Egr-1 messenger RNA in the myogenic cell line Sol8. Among these are endothelin, insulin, basic fibroblast growth factor, and platelet-derived growth factor BB (PDGF BB). We conclude: (1) In analogy to the myocardium, these growth factors act upon myoblasts. (2) This line appears to be a suitable model for the molecular characterization of Egr-1 target genes. [less ▲]

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See detailUne communauté sur le déclin? Les marchands hollandais à Bordeaux, 1650 - 1715
Voss, Peter UL

in Bulletin du Centre d'Histoire des Espaces Atlantiques (1995), 7

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See detailEditorial
Tröhler, Daniel UL

in Neue Pestalozzi-Blätter (1995), 1

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See detailSomatostatin-like immunoreactivity in primary afferents of the medial articular nerve and colocalization with substance P in the cat
Hanesch, Ulrike UL; Heppelmann, Bernd; Schmidt, Robert

in Journal of Comparative Neurology (1995), 354

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See detailThe role of APO-1-mediated apoptosis in the immune system
Krammer, P. H.; Dhein, J.; Walczak, H. et al

in Immunological Reviews (1995), 142

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See detailMorphine, 5-HT 2 and 5-HT 3 recpror antagonists reduce c-Fos expresion in the trigeminal nuclear complex follwing noxious chemical stimulation of the rat nasal mucosa
Ebersberger, Andrea; Anton, Fernand UL; Tölle, Thomas et al

in Brain Research (1995), 676(2), 336-342

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See detailProvisional Utopias in a Post-Colonial World. Een interview met Peter McLaren.
Biesta, Gert UL; Miedema, S.

in Comenius (1995), 15(3), 335-347

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See detailCHALLENGING TIMES FOR BIOINFORMATICS
CASARI, G.; ANDRADE, M. A.; BORK, P. et al

in Nature (1995), 376(6542), 647-648

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See detailPestalozzi für den Schulgebrauch
Tröhler, Daniel UL

in Schweizerische Lehrerinnen- und Lehrer-Zeitung (1995), 140(23-24), 15-15

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See detailThe Imagination of a Radical Democracy. Een interview met Henry Giroux.
Miedema, S.; Biesta, Gert UL

in Comenius (1995), 15(2), 194-205

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See detailÄrgerbewältigungstraining
Steffgen, Georges UL; Schwenkmezger, Peter

in Psychologie und Sport (1995), 2(3), 89-95

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See detailCalcitonin gene-related peptide released from dural nerve fibers mediates increase of meningeal blood flow in the rat.
Meßlinger, Karl; Hanesch, Ulrike UL; Kurosawa, Mieko et al

in Canadian Journal of Physiology & Pharmacology (1995)

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