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See detailComplete lifts of connections and stochastic Jacobi fields
Arnaudon, Marc; Thalmaier, Anton UL

in Journal de Mathématiques Pures et Appliquées (1998), 77(3), 283-315

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See detailMeer pedagogiek in de lerarenopleiding?
Biesta, Gert UL

in Tijdschrift voor lerarenopleiders (1998), 19(2), 69-74

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See detailDirect clustering of a two-mode binary data-matrix
Krolak-Schwerdt, Sabine UL; Orlik, Peter

in Universität des Saarlandes: Arbeiten der Fachrichtung Psychologie (1998), 186

In this paper a discrete, categorical model is proposed for two-:­ mode data matrices with binary entries Xij E {0, 1}. The method operates directly upon a raw input (objects by attributes) data array by ... [more ▼]

In this paper a discrete, categorical model is proposed for two-:­ mode data matrices with binary entries Xij E {0, 1}. The method operates directly upon a raw input (objects by attributes) data array by determining two-mode submatrices whose entries entirely have values x;j = 1. In addition, different submatrices are required to have a minimum set of objectattribute- pairs in common. Objects and attributes are classified simultaneously in a number ofjoint clusters. The method may be characterized as a non-hierarchical clustering procedure and in its model function to predict the data it is similar to Boolean factor analy􀢛is. Basically, the proposed method dubbed ' GRIDPAT' (for 'PATtern analysis of GRIDs') was developped for the structural representation of self concept data. Its relations to basic notions of Formal Concept Analysis and blockmodeling are discussed. An illustrative application of the approach is provided. [less ▲]

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See detailEditorial
Tröhler, Daniel UL

in Neue Pestalozzi-Blätter (1998), 4(2), 1-1

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See detailWeighted Subspace Fitting for General Array Error Models
Jansson, Magnus; Swindlehurst, A. Lee; Ottersten, Björn UL

in IEEE Transactions on Signal Processing (1998), 46(9), 24842498

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See detailPedagogy without humanism. Foucault and the subject of education.
Biesta, Gert UL

in Interchange (1998), 29(1), 1-16

Detailed reference viewed: 175 (1 UL)
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See detailThe HSSP database of protein structure sequence alignments and family profiles
Dodge, C.; Schneider, Reinhard UL; Sander, C.

in Nucleic Acids Research (1998), 26(1), 313-315

HSSP (http://www.sander.embl-ebi.ac.uk/hssp/) is a derived database merging structure (3-D) and sequence (1-D) information, For each protein of known 3D structure from the Protein Data Bank (PDB), we ... [more ▼]

HSSP (http://www.sander.embl-ebi.ac.uk/hssp/) is a derived database merging structure (3-D) and sequence (1-D) information, For each protein of known 3D structure from the Protein Data Bank (PDB), we provide a multiple sequence alignment of putative homologues and a sequence profile characteristic of the protein family, centered on the known structure. The list of homologues is the result of an iterative database search in SWISS-PROT using a position-weighted dynamic programming method for sequence profile alignment (MaxHom). The database is updated frequently, The listed putative homologues are very likely to have the same 3D structure as the PDB protein to which they have been aligned. As a result, the database not only provides aligned sequence families, but also implies secondary and tertiary structures covering 33% of all sequences in SWISS-PROT. [less ▲]

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See detailSugawara construction and Casimir operators for Krichever-Novikov algebras
Schlichenmaier, Martin UL; Sheinman, Oleg K.

in Journal of Mathematical Sciences (1998), 92(2), 3807-3834

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See detailDie kommunale grenzüberschreitende Zusammenarbeit - Basis und Motor der europäischen Integration? Das Beispiel Saar-Lor-Lux.
Schulz, Christian UL

in Berichte zur Deutschen Landeskunde (1998), 1998(4), 267-290

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See detailComments on "Min-Norm Interpretations and Consistency of MUSIC, MODE and ML"
Stoica, Petre; Ottersten, Björn UL

in IEEE Transactions on Signal Processing (1998), 46(8), 22622263

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See detailConduction in nonstoichiometric molecular-beam epitaxial GaAs grown above the critical thickness
Kordoš, P.; Marso, Michel UL; Luysberg, M.

in Applied Physics Letters (1998), 72

Different conduction behavior is observed in nonstoichiometric ~NS! molecular-beam epitaxial GaAs grown at 200 °C below and above the critical thickness. In the low-field Ohmic region only the ... [more ▼]

Different conduction behavior is observed in nonstoichiometric ~NS! molecular-beam epitaxial GaAs grown at 200 °C below and above the critical thickness. In the low-field Ohmic region only the monocrystalline part of the layer contributes to the room-temperature resistivity, but at higher temperatures the resistivity scales with the total layer thickness. In NS GaAs grown above the critical thickness, a superlinear J –V^n (n=2 – 3) dependence is found at intermediate fields. The prebreakdown voltage is proportional to the total thickness. This indicates that different defects control the electrical properties of the polycrystalline and monocrystalline parts of the NS GaAs. These results can be useful in the design of NS GaAs based devices, which operate at higher temperature and/or higher electric fields. [less ▲]

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See detailCalibration of a superconducting gravimeter by comparison with an absolute gravimeter FG5 in Boulder
Francis, Olivier UL; Niebauer, T. M.; Sasagawa, G. et al

in Geophysical Research Letters (1998), 25(7), 1075-1078

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See detailSpinocerebellar ataxia type 6: genotype and phenotype in German kindreds.
Schols, L.; Krüger, Rejko UL; Amoiridis, G. et al

in Journal of neurology, neurosurgery, and psychiatry (1998), 64(1), 67-73

OBJECTIVE: Spinocerebellar ataxia type 6 (SCA6) is an autosomal dominant cerebellar ataxia (ADCA) of which the mutation causing the disease has recently been characterised as an expanded CAG trinucleotide ... [more ▼]

OBJECTIVE: Spinocerebellar ataxia type 6 (SCA6) is an autosomal dominant cerebellar ataxia (ADCA) of which the mutation causing the disease has recently been characterised as an expanded CAG trinucleotide repeat in the gene coding for the alpha1A-subunit of the voltage dependent calcium channel. The aim was to further characterise the SCA6 phenotype METHODS: The SCA6 mutation was investigated in 69 German families with ADCA and 61 patients with idiopathic sporadic cerebellar ataxia and the CAG repeat length of the expanded allele was correlated with the disease phenotype. RESULTS: Expanded alleles were found in nine of 69 families as well as in four patients with sporadic disease. Disease onset ranged from 30 to 71 years of age and was significantly later than in other forms of ADCA. Age at onset correlated inversely with repeat length. The SCA6 phenotype comprises predominantly cerebellar signs in concordance with isolated cerebellar atrophy on MRI. Non-cerebellar systems were only mildly affected with external ophthalmoplegia, spasticity, peripheral neuropathy, and parkinsonism. Neither these clinical signs nor progression rate correlated with CAG repeat length. CONCLUSIONS: This study provides the first detailed characterisation of the SCA6 phenotype. Clinical features apart from cerebellar signs were highly variable in patients with SCA6. By comparison with SCA1, SCA2, and SCA3 no clinical or electrophysiological finding was specific for SCA6. Therefore, the molecular defect cannot be predicted from clinical investigations. In Germany, SCA6 accounts for about 13% of families with ADCA. However, up to 30% of SCA6 kindreds may be misdiagnosed clinically as sporadic disease due to late manifestation in apparently healthy parents. Genetic testing is therefore recommended for the SCA6 mutation also in patients with putative sporadic ataxia. [less ▲]

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See detailPicture or word superiority effects in implicit memory: levels of processing, attention and retrieval constraints
Wippich, Werner; Melzer, André UL; Mecklenbräuker, Silvia

in Swiss Journal of Psychology = Schweizerische Zeitschrift für Psychologie = Revue suisse de psychologie (1998), 51(1), 33-46

Previous research with implicit memory tests has shown that the typical picture superiority effect with explicit memory instructions can he reversed on verbal perceptual tests (e.g., word-stem completion ... [more ▼]

Previous research with implicit memory tests has shown that the typical picture superiority effect with explicit memory instructions can he reversed on verbal perceptual tests (e.g., word-stem completion task). Two experiments explored whether the picture superiority effect can be restored with a verbal conceptual test of implicit memory (i.e., category instance generation task). In the first experiment, participants received either a perceptual test or a conceptual test of implicit memory. Furthermore, in the study phase level of processing was varied. With a superficial orienting task, a word superiority effect was found on the perceptual test and a picture superiority effect was observed on the conceptual test. Only with a semantic orienting task, priming was found for pictures on the perceptual test and for words on the conceptual test. In the second experiment, this pattern of findings was replicated with a superficial orienting task in the study phase. Once again priming for pictures on the perceptual test and priming for words on the conceptual test was found to be at chance level. Dividing attention in the study phase did not influence these results. [less ▲]

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See detailJugend in der DDR. FDJ-Mitgliedschaft und Systemverbundenheit Jugendlicher in den Jahren 1970 bis 1989. Sozialisation und Entwicklung in den neuen Bundesländern. Ergebnisse empirischer Längsschnittforschung.
Bien, Walter; Bischoff, Peter; Willems, Helmut UL

in Zeitschrift für Soziologie der Erziehung und Sozialisation = Journal for Sociology of Education and Socialization (1998)

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See detailReliability and Validity of the Southern California Ordinal Scales of Development for a Sample of Young Children with Disabilities
Pit-Ten Cate, Ineke UL; Miller, A. Cate; Rosen, Carol et al

in Journal of Psychoeducational Assessment (1998), 16(1), 4-14

The primary purpose of this study was to inves­tigate the reliability and validity of the Southern California Ordinal Scales of Development (SCOSD) . The SCOSD is a criterion-referenced test that assesses ... [more ▼]

The primary purpose of this study was to inves­tigate the reliability and validity of the Southern California Ordinal Scales of Development (SCOSD) . The SCOSD is a criterion-referenced test that assesses six domains of development and was designed for use with children with disabilities. Results found that the SCOSD alpha internal consistency coefficients ranged from .94 to .98; percent agreement between raters ranged from 85% to 100%; and inter­ rater correlations ranged from .96 to .99. Strong intercorrelations were found between the SCOSD and standardized domain-specific instruments (.65 to .92), providing evidence of concurrent validity. The secondary purpose was to investigate patterns of development across domains of the children's functioning. As expected, results revealed a hierarchy of skill development, with the children showing relatively less development in gross-motor skills and practical abilities. [less ▲]

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See detailOverexpression of the sarcolemmal calcium pump in the myocardium of transgenic rats.
Hammes, A.; Oberdorf-Maass, S.; Rother, T. et al

in Circulation Research (1998), 83(9), 877-88

The plasma membrane calmodulin-dependent calcium ATPase (PMCA) is a calcium-extruding enzyme controlling Ca2+ homeostasis in nonexcitable cells. However, its function in the myocardium is unclear because ... [more ▼]

The plasma membrane calmodulin-dependent calcium ATPase (PMCA) is a calcium-extruding enzyme controlling Ca2+ homeostasis in nonexcitable cells. However, its function in the myocardium is unclear because of the presence of the Na+/Ca2+ exchanger. We approached the question of the physiological function of the calcium pump using a transgenic "gain of function" model. Transgenic rat lines carrying the human PMCA 4 cDNA under control of the ventricle-specific myosin light chain-2 promoter were established, and expression in the myocardium was ascertained at the mRNA, protein, and functional levels. In vivo hemodynamic measurements in adult homozygous animals showed no differences in baseline and increased cardiac performance recruited by volume overload compared with controls. No differences between transgenic and control cardiomyocytes were found in patch clamp voltage dependence, activation/inactivation behavior of the L-type Ca2+ current, or fast [Ca2+]i transients (assessed by the Fura-2 method). To test whether the PMCA might be involved in processes other than beat-to-beat regulation of contraction/relaxation, we compared growth processes of neonatal transgenic and control cardiomyocytes. A 1.6- and 2.3-fold higher synthesis rate of total protein was seen in cells from transgenic animals compared with controls on incubation with 2% FCS for 24 hours and 36 hours, respectively. An effect of similar magnitude was observed using 20 micromol/L phenylephrine. A 1.4-fold- and 2.0-fold-higher protein synthesis peak was seen in PMCA-overexpressing cardiomyocytes after stimulation with isoproterenol for 12 hours and 24 hours, respectively. Because pivotal parts of the alpha- and beta-adrenergic signal transduction pathways recently have been localized to caveolae, we tested the hypothesis that the PMCA might alter the amplitude of alpha- and beta-adrenergic growth signals by virtue of its localization in caveolae. Biochemical as well as immunocytochemical studies suggested that the PMCA in large part was colocalized with caveolin 3 in caveolae of cardiomyocytes. These results indicate that the sarcolemmal Ca2+-pump has little relevance for beat-to-beat regulation of contraction/relaxation in adult animals but likely plays a role in regulating myocardial growth, possibly through modulation of caveolar signal transduction. [less ▲]

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See detailSelegiline as immunostimulant--a novel mechanism of action?
Muller, T.; Kuhn, W.; Krüger, Rejko UL et al

in Journal of neural transmission. Supplementum (1998), 52

In clinical studies the MAO-B inhibitor selegiline appears to slow the progression of neurological deficits in Parkinson's disease (PD) and the cognitive decline in Alzheimer's disease (AD). The ... [more ▼]

In clinical studies the MAO-B inhibitor selegiline appears to slow the progression of neurological deficits in Parkinson's disease (PD) and the cognitive decline in Alzheimer's disease (AD). The mechanisms of action remain unclear. Several lines of evidence indicate an immune-mediated pathophysiology of PD and AD. According to animal trials, selegiline increases the survival rate of immune suppressed mice. Stimulation of the immune response to bacterial or viral infection or in chronic inflammatory processes in managed by an increased synthesis of the cytokines interleukin-1 beta (IL-1 beta) and subsequent interleukin-6 (IL-6). Outcome of viral or bacterial infections in the brain highly correlates with levels of the cytotoxic cytokine tumor-necrosis-factor-alpha (TNF). The aim of our study was to characterize the influence of selegiline on the biosynthesis of IL-1 beta, IL-6 and TNF in human peripheral blood mononuclear cells (PBMC) from healthy blood donors. After isolation and washing PBMC were cultured without and with selegiline in three different concentrations (0.01 mumol/l, 0.001 mumol/l, 0.0001 mumol/l) in a humidified atmosphere (7% CO2). Then cultures were centrifuged and supernatants were collected for IL-1 beta, IL-6 and TNF ELISA-assays. Treatment of cultured PBMC with various concentrations induced an increased synthesis of IL-1 beta (ANOVA F = 9.703, p = 0.0007), IL-6 (ANOVA F = 20.648, p = 0.0001) and a reduced production of TNF (ANOVA F = 3.770, p = 0.040). These results indicate, that the influence of selegiline on the cytokine biosynthesis may also contribute to its putative neuroprotective properties. [less ▲]

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See detailInhibitory action of BMPs on Pax1 expression and on shoulder girdle formation during limb development.
Hofmann, C.; Drossopoulou, G.; McMahon, A. et al

in Developmental Dynamics : An Official Publication of the American Association of Anatomists (1998), 213(2), 199-206

Pax1 expression in vertebrate limb buds is confined to cells in a discrete anterior proximal domain (Timmons et al. [1994] Development 120:2773-2785; Ebensperger et al. [1995] Anat. Embryol. 191:297-310 ... [more ▼]

Pax1 expression in vertebrate limb buds is confined to cells in a discrete anterior proximal domain (Timmons et al. [1994] Development 120:2773-2785; Ebensperger et al. [1995] Anat. Embryol. 191:297-310). In dorsoventral patterning of Drosophila, expression of pox meso, an insect gene with high sequence similarity to Pax1, is repressed by decapentaplegic (dpp) in dorsal mesoderm and, thus, is restricted to a discrete ventral domain (Staehling-Hampton et al. [1994] Nature 372:783-786). In the chick wing, cells expressing a vertebrate homolog of dpp, bone morphogenetic protein 4 (Bmp4), abut the Pax1 domain, suggesting a similar relationship between homologous genes in both vertebrates and invertebrates. Here, we show that two BMPs (BMP4, and BMP2, also highly related to dpp) can repress Pax1 in the developing chick wing. Chick wing bud cells expressing Pax1 give rise to the shoulder girdle. Cells in an equivalent position in the mouse forelimb also express Pax1, and Pax1 mutant mice display shoulder girdle defects. Similarly in chick embryos, girdle defects are produced by treatments with signalling molecules that lead to expression of BMPs, which subsequently reduce Pax1 expression in the limb bud. Recently, BMP4 has been shown to inhibit Pax1 expression in the developing trunk (Monsoro-Burq et al. [1996] Development 122:3607-3616) and Pax9 expression in developing teeth (Neubuser et al. [1997] Cell 90:247-255). Thus, a property of BMPs appears to be to regulate pox meso homologs negatively and, thus, limit their expression domains. [less ▲]

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See detailPsychological factors associated with the uptake of measles immunization. Findings and implications for prevention.
Weitkunat, Rolf; Markuzzi, Andreas; Vogel, Susanne et al

in Journal of Health Psychology (1998), 3(2)

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See detailCovariance Matching Estimation Techniques for Array Signal Processing Applications
Ottersten, Björn UL; Stoica, Petre; Roy, R.

in Digital Signal Processing (1998), 8

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See detailPartial amplification of the measles virus nucleocapsid gene from stored sera and cerebrospinal fluids for molecular epidemiological studies
Kreis, Stephanie UL; Schoub, B. D.

in Journal of Medical Virology (1998), 56(2), 174-177

The analysis of stored sera for retrospective molecular epidemiological studies provides a powerful tool to investigate strain variation in measles viruses that had circulated up to 20 years ago. For this ... [more ▼]

The analysis of stored sera for retrospective molecular epidemiological studies provides a powerful tool to investigate strain variation in measles viruses that had circulated up to 20 years ago. For this purpose, a rapid and simple method for extraction of RNA from stored sera and cerebrospinal fluids (CSF) was developed. When used on sera and CSFs that have been frozen for as long as 20 years, this method proved to be more efficient than established techniques. The extracted RNA was reverse transcribed into cDNA by using random hexamer primers. The PCR amplification of the 3' terminus of the nucleocapsid gene (N) was divided into two overlapping fragments of 375 and 384 bp length, covering the entire region of interest. This region is thought to have the highest variability within the MV genome and has previously been shown to be suitable for strain characterization. The resulting PCR fragments were sequenced manually by using standard methods without the need of further clean-up steps. [less ▲]

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See detailThe SOX10/Sox10 gene from human and mouse: sequence, expression, and transactivation by the encoded HMG domain transcription factor.
Pusch, C.; Hustert, E.; Pfeifer, D. et al

in Human Genetics (1998), 103(2), 115-23

The SOX genes form a gene family related by homology to the high-mobility group (HMG) box region of the testis-determining gene SRY. We have cloned and sequenced the SOX10 and Sox10 genes from human and ... [more ▼]

The SOX genes form a gene family related by homology to the high-mobility group (HMG) box region of the testis-determining gene SRY. We have cloned and sequenced the SOX10 and Sox10 genes from human and mouse, respectively. Both genes encode proteins of 466 amino acids with 98% sequence identity. Significant expression of the 2.9-kb human SOX10 mRNA is observed in fetal brain and in adult brain, heart, small intestine and colon. Strong expression of Sox10 occurs throughout the peripheral nervous system during mouse embryonic development. SOX10 shows an overall amino acid sequence identity of 59% to SOX9. Like SOX9, SOX10 has a potent transcription activation domain at its C-terminus and is therefore likely to function as a transcription factor. Whereas SOX9 maps to 17q, a SOX10 cosmid has previously been mapped by us to the region 22q13.1. Mutations in SOX10 have recently been identified as one cause of Waardenburg-Hirschsprung disease in humans, while a Sox10 mutation underlies the mouse mutant Dom, a murine Hirschsprung model. [less ▲]

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See detailStadtentwicklung im Zeichen von "Auflösung" und Nachhaltigkeit.
Hesse, Markus UL; Schmitz, Stefan

in Informationen zur Raumentwicklung (1998), 7/8

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See detailEvaluation of the information processing and mood effects of a transdermal nicotine patch.
Warburton, D. M.; Mancuso, Giovanna UL

in Psychopharmacology (1998), 135(3), 305-10

The purpose of this study was to determine whether a transdermal nicotine patch will produce the same effects on performance and mood as cigarette smoking. The nicotine patch improved attentional ... [more ▼]

The purpose of this study was to determine whether a transdermal nicotine patch will produce the same effects on performance and mood as cigarette smoking. The nicotine patch improved attentional processing and produced some improvements in memory. It produced the calming effects of smoking and induced feelings of happiness which were increased with smoking. These effects were obtained 6 h after application of the patch, showing that acute tolerance for these behavioural effects had not developed completely, if at all, after exposure to nicotine, although it is still possible that tolerance might occur with longer exposure. [less ▲]

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See detailTime depending Malliavin calculus on manifolds and application to nonlinear filtering
Schiltz, Jang UL

in Probability and Mathematical Statistics (1998), 18(2), 319-334

In this paper, we prove, using Malliavin calculus, that under a global Hormander condition the law of a Riemannian manifold valued stochastic process, a solution of a stochastic differential equation with ... [more ▼]

In this paper, we prove, using Malliavin calculus, that under a global Hormander condition the law of a Riemannian manifold valued stochastic process, a solution of a stochastic differential equation with time dependent coefficients, admits a smooth density with respect to the Riemannian volume element. This result is applied to a nonlinear filtering problem with time dependent coefficients on manifolds. [less ▲]

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See detailDer Verkehr als Gegenstand raumbezogener Forschung. Theoretische Überlegungen zur Bedeutung der Transport- und Transaktionskosten.
FLÄMIG, Heike; Hesse, Markus UL

in Geographische Zeitschrift (1998), 86(4), 225-235

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See detailVirtual Convergence and Dialect Levelling in Luxemburgish
Gilles, Peter UL

in Folia Linguistica (1998), 32(1-2), 69-82

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See detailThe M2 muscarinic receptor antagonist methoctramine activates mast cells via pertussis toxin-sensitive G proteins
Chahdi, A.; Daeffler, L.; Bueb, Jean-Luc UL et al

in Naunyn-Schmiedeberg's Archives of Pharmacology (1998), 357(4), 357-62

Methoctramine, a selective M2 muscarinic cholinergic receptor antagonist, has been reported to activate phosphoinositide breakdown at high concentrations. Its polyamine structure suggests a putative ... [more ▼]

Methoctramine, a selective M2 muscarinic cholinergic receptor antagonist, has been reported to activate phosphoinositide breakdown at high concentrations. Its polyamine structure suggests a putative activation of guanine nucleotide-binding proteins (G proteins). Incubation of methoctramine with rat peritoneal mast cells resulted in a dose-dependent noncytotoxic histamine release, with an EC50 of 20 microM and a maximum effect at 1 mM. Atropine, pirenzepine and HHSiD neither inhibited methoctramine-induced histamine release nor stimulated histamine release. Histamine release and inositol phosphates generation induced by methoctramine were both inhibited by pertussis toxin pretreatment. Benzalkonium chloride, a selective inhibitor of histamine secretion induced by basic secretagogues, inhibited the secretory response to methoctramine. [p-Glu5, D-Trp7,9,l0]-SPs5-11 (GPAnt-2), a well-characterized antagonist of G proteins, blocked the methoctramine-induced histamine release when the antagonist was allowed to reach its intracellular target by streptolysin O-permeabilization. The response to methoctramine was prevented by the hydrolysis of sialic acid residues of the cell surface by neuraminidase. The response of mast cells was restored by permeabilization of the plasma membrane. These results demonstrate that methoctramine, following its entry into the cell and the involvement of pertussis toxin-sensitive G proteins, activates phosphoinositide hydrolysis leading to mast cell exocytosis. [less ▲]

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See detailSome remarks on the heat flow for functions and forms
Thalmaier, Anton UL

in Electronic Communications in Probability (1998), 3

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See detailReview of Peter McLaren, Revolutionary Multiculturalism.
Biesta, Gert UL

in Educational Studies (1998), 29(3), 298-302

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See detailDeconstruction, justice and the question of education.
Biesta, Gert UL

in Zeitschrift für Erziehungswissenschaft (1998), 1(3), 395-411

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See detailSelectively Grown Vertical Si MOS Transistor with Reduced Overlap Capacitances
Klaes, D.; Moers, J.; Tönnesmann, A. et al

in Thin Solid Films (1998), 336(1998), 306-308

Vertical p-MOS transistors with channel length of 130 nm have been fabricated using selective epitaxial growth (SEG) to define the channel region. The vertical layout offers the advantages of achieving ... [more ▼]

Vertical p-MOS transistors with channel length of 130 nm have been fabricated using selective epitaxial growth (SEG) to define the channel region. The vertical layout offers the advantages of achieving short channel lengths and high integration densities while still using optical lithography to define lateral dimensions. Compared to other vertical concepts, this layout has reduced gate to source/drain overlap capacitances which is necessary for high speed applications. The use of SEG instead of blanket epitaxy avoids the deterioration of the Si/SiO2 interface due to reactive ion etching (RIE) and reduces punch-through due to facet growth. First non-optimized p-channel MOSFETs with a 12-nm gate oxide show a transconductance of 90 mS/mm. The cut-off frequencies of this device turned out to be f T = 2.3 GHz and f max = 1.1 GHz. [less ▲]

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See detailWe need more mutants: Plans for a large scale ENU mouse mutagenesis screen
Balling, Rudi UL; Hrabe de Angelis, M; Schughart, K et al

in OECD Economics Department Working Papers (1998), (98), 103-111

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See detailExponential actions and maximal D-invariant ideals
Molitor-Braun, Carine UL

in Manuscripta Mathematica (1998), 96(1), 23-35

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See detailGradient estimates for harmonic functions on regular domains in Riemannian manifolds
Thalmaier, Anton UL; Wang, Feng-Yu

in Journal of Functional Analysis (1998), 155(1), 109-124

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See detailStädtischer Wirtschaftsverkehr als Gegenstand der kommunalen Planung. Möglichkeiten und Grenzen privat-öffentlicher Kooperation.
Hesse, Markus UL

in Archiv für Kommunalwissenschaften (1998), II

Der Beitrag skizziert aktuelle Tendenzen im System der Logistik und ihre Bedeutung für die Stadtentwicklung. Ein besonderes Augenmerk liegt auf dem Handlungsrahmen der Stadtplanung, mit ihren ... [more ▼]

Der Beitrag skizziert aktuelle Tendenzen im System der Logistik und ihre Bedeutung für die Stadtentwicklung. Ein besonderes Augenmerk liegt auf dem Handlungsrahmen der Stadtplanung, mit ihren Rechtsetzungen und Strategien Leitplanken für eine stadtverträgliche Logistik zu setzen. [less ▲]

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See detailCardiovascular effects of Org 9487 under isoflurane anaesthesia in man
Osmer, Christian; Wulf, Kay; Vögele, Claus UL et al

in European Journal of Anaesthesiology (1998), (15), 585-589

The cardiovascular effects of Org 9487 during isoflurane anaesthesia have been evaluated using three doses around its ED90 for neuromuscular blockade, i.e. 1 mg kg-1, 2 mg kg-1 and 3 mg kg-1. Heart rate ... [more ▼]

The cardiovascular effects of Org 9487 during isoflurane anaesthesia have been evaluated using three doses around its ED90 for neuromuscular blockade, i.e. 1 mg kg-1, 2 mg kg-1 and 3 mg kg-1. Heart rate increased to 110%, 115% and 118% in patients receiving 1 mg kg-1, 2 mg kg-1 and 3 mg kg-1 respectively. There were no significant effects on systolic and diastolic blood pressures for the two lower dose groups. Patients receiving Org 9487 3 mg kg-1 displayed significant decreases in systolic and diastolic blood pressures (91% and 82% of the control values respectively). Except for heart rate in the group receiving 3 mg kg-1, all measurements returned to baseline after a maximum of 15 min. Six patients experienced a transient increase in airway pressure after administration of Org 9487, which was accompanied by a decrease in oxygen saturation in two out of six subjects, but there was no audible wheezing. These episodes were self-limiting and required no treatment. There were no other adverse reactions to this drug during this study. [less ▲]

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See detailBildung - ein schulpädagogischer Begriff?
Tröhler, Daniel UL

in Infos und Akzente (1998), (1), 10-17

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See detailReview of: J. Thornborrow & S. Wareing. Patterns in Language
Weber, Jean-Jacques UL

in Functions of Language (1998), 5

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See detailAla30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease.
Krüger, Rejko UL; Kuhn, W.; Muller, T. et al

in Nature genetics (1998), 18(2), 106-8

Detailed reference viewed: 270 (8 UL)
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See detailGenetic dissection of familial Parkinson's disease.
Riess, O.; Jakes, R.; Krüger, Rejko UL

in Molecular Medicine Today (1998), 4(10), 438-44

In the past few years, the genetic contribution to Parkinson's disease (PD) has gained major attention and has resulted in the identification of the first mutant gene, called alpha-synuclein, involved in ... [more ▼]

In the past few years, the genetic contribution to Parkinson's disease (PD) has gained major attention and has resulted in the identification of the first mutant gene, called alpha-synuclein, involved in the pathogenesis of autosomal-dominant PD. alpha-Synuclein is a major component of Lewy bodies, which are a neuropathological feature of PD. Furthermore, deletions in the parkin gene have been identified as the primary cause in rare forms of autosomal-recessive juvenile PD. The elucidation of polygenic changes in the dopamine pathway, mitochondrial dysfunction, and metabolism of xenobiotics is now technically possible by means of association and genotype studies. The increasing knowledge of the pathogenesis of PD at a molecular level will have important implications for the development of individual therapeutic strategies to prevent disease progression. [less ▲]

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See detailNecessary conditions for robust stability of a class of nonlinear systems
Goncalves, Jorge UL; Dahleh, M. A.

in Automatica (1998), 34(6), 705-714

Input-output stability results for feedback systems are developed. Robust stability conditions are presented for nonlinear systems with nonlinear uncertainty defined by some function (with argument equal ... [more ▼]

Input-output stability results for feedback systems are developed. Robust stability conditions are presented for nonlinear systems with nonlinear uncertainty defined by some function (with argument equal to the norm of the input) that bounds its output norm. A sufficient small gain theorem for a class of these systems is known. Here, necessary conditions are presented for the vector space (L- infinity ll . ll infinity). These results capture the conservatism of the small gain theorem as it is applied to systems that do not have linear gain. The theory is also developed for the case of L2 signal norms, indicating some difficulties which make this case less natural than L-infinity. [less ▲]

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See detailEditorial
Tröhler, Daniel UL

in Neue Pestalozzi-Blätter (1998), 4(1), 1-1

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See detailGeneralized Morse potential: Symmetry and satellite potentials
del Sol Mesa, Antonio UL

in Journal of Physics: A Mathematical and General (1998)

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See detailPax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities.
Peters, H.; Neubuser, A.; Kratochwil, K. et al

in Genes and Development (1998), 12(17), 2735-47

Pax genes have been shown to play important roles in mammalian development and organogenesis. Pax9, a member of this transcription factor family, is expressed in somites, pharyngeal pouches, mesenchyme ... [more ▼]

Pax genes have been shown to play important roles in mammalian development and organogenesis. Pax9, a member of this transcription factor family, is expressed in somites, pharyngeal pouches, mesenchyme involved in craniofacial, tooth, and limb development, as well as other sites during mouse embryogenesis. To analyze its function in vivo, we generated Pax9 deficient mice and show that Pax9 is essential for the development of a variety of organs and skeletal elements. Homozygous Pax9-mutant mice die shortly after birth, most likely as a consequence of a cleft secondary palate. They lack a thymus, parathyroid glands, and ultimobranchial bodies, organs which are derived from the pharyngeal pouches. In all limbs, a supernumerary preaxial digit is formed, but the flexor of the hindlimb toes is missing. Furthermore, craniofacial and visceral skeletogenesis is disturbed, and all teeth are absent. In Pax9-deficient embryos tooth development is arrested at the bud stage. At this stage, Pax9 is required for the mesenchymal expression of Bmp4, Msx1, and Lef1, suggesting a role for Pax9 in the establishment of the inductive capacity of the tooth mesenchyme. In summary, our analysis shows that Pax9 is a key regulator during the development of a wide range of organ primordia. [less ▲]

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See detailL'autonomie des garanties à première demande, analyse comparative avec les effets de commerce
Prüm, André UL

in Waseda Proceedings of Comparative Law (1998), 2

Detailed reference viewed: 94 (2 UL)
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See detail[Compression therapy of a ruptured spurious aneurysm].
Beer, M.; Tschammler, A.; Wittenberg, G. et al

in RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin (1998), 168(3), 291-3

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See detailJean de Luxembourg, prince idéal et chevalier parfait. Aux origines d'un mythe
Margue, Michel UL

in Mediaevalia Historica Bohemica (1998), 5

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See detailRelating factor matrices of different dimensionality: A note on optimizing orthogonal procrustes solutions
Krolak-Schwerdt, Sabine UL; Orlik, Peter

in Universität des Saarlandes: Arbeiten der Fachrichtung Psychologie (1998), 187

l'vlatching by the Procrustes method involves the transformation of a matrix A to maximal agreement with a specified target matrix B. The present paper is concerned with the soluti on of the 'Orthogonal ... [more ▼]

l'vlatching by the Procrustes method involves the transformation of a matrix A to maximal agreement with a specified target matrix B. The present paper is concerned with the soluti on of the 'Orthogonal Procrustes problem' when the column orders of A and B are different. Avai lable techniques ei ther yield nonunique solutious or the column order of one matrix has to be adjusted by truncating or adding some columns. A new method i s advanced which provides a unique sol,ut.ion without constraining the number of columns of corresponding matrices. An illustrative example is given. [less ▲]

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See detailRez. zu Ingrid Samel: Einführung in die feministische Sprachwissenschaft
Sieburg, Heinz UL

in Zeitschrift für Deutsche Philologie (1998), 117

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See detail«Pijn als een passie bij Antonin Artaud»
Roelens, Nathalie UL

in Streven (1998)

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See detailSerum lipid concentrations, hostility, and cardiovascular reactions to mental stress
Vögele, Claus UL

in International Journal of Psychophysiology (1998), 28

The objective of the present study was to determine whether serum lipid concentrations interact with hostility to affect cardiovascular responses to mental stress. One-hundred and seventy-four male ... [more ▼]

The objective of the present study was to determine whether serum lipid concentrations interact with hostility to affect cardiovascular responses to mental stress. One-hundred and seventy-four male subjects were screened with the Cook and Medley hostility scale (Ho), the anger expression inventory by Spielberger and a general health questionnaire. Subjects in the upper (n = 22) and lower (n = 22) quartile of the Ho score distribution were asked to take part in a laboratory experiment. Continuous measures of heart rate, blood pressure, respiration and electrodermal activity were taken while participants carried out a series of behavioral maneuvres, including mental arithmetic and mirror star tracing. Prior to the experiment fasting blood samples were taken for lipid determinations. The results show higher heart rate reactivity in high hostile than low hostile subjects. High hostile subjects also reported more anger and frustration in response to tasks. Hostility groups differed in lipid levels in that high hostiles had higher triglyceride and VLDL-c concentrations than low hostiles. Cholesterol levels showed an inverse association with cardiovascular reactivity but only in low hostile subjects. No such associations could be found in high hostiles. We conclude that there is partial support for both, the hyperreactivity and the health behavior model linking hostility and cardiovascular disorder. [less ▲]

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See detailEuropean Community Criminal Law
Ligeti, Katalin UL

in Acta Juridica Hungarica (1998)

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See detailDistinct involvement of beta3 integrin cytoplasmic domain tyrosine residues 747 and 759 in integrin-mediated cytoskeletal assembly and phosphotyrosine signaling.
Schaffner-Reckinger, Elisabeth UL; Gouon, V.; Melchior, Chantal UL et al

in The Journal of biological chemistry (1998), 273(20), 12623-32

We have investigated the structural requirements of the beta3 integrin subunit cytoplasmic domain necessary for tyrosine phosphorylation of focal adhesion kinase (FAK) and paxillin during alphav beta3 ... [more ▼]

We have investigated the structural requirements of the beta3 integrin subunit cytoplasmic domain necessary for tyrosine phosphorylation of focal adhesion kinase (FAK) and paxillin during alphav beta3-mediated cell spreading. Using CHO cells transfected with various beta3 mutants, we demonstrate a close correlation between alphav beta3-mediated cell spreading and tyrosine phosphorylation of FAK and paxillin, and highlight a distinct involvement of the NPLY747 and NITY759 motifs in these signaling processes. Deletion of the NITY759 motif alone was sufficient to completely prevent alphav beta3-dependent focal contact formation, cell spreading, and FAK/paxillin phosphorylation. The single Y759A substitution induced a strong inhibitory phenotype, while the more conservative, but still phosphorylation-defective, Y759F mutation restored wild type receptor function. Alanine substitution of the highly conserved Tyr747 completely abolished alphav beta3-dependent formation of focal adhesion plaques, cell spreading, and FAK/paxillin phosphorylation, whereas a Y747F substitution only partially restored these events. As none of these mutations affected receptor-ligand interaction, our results suggest that the structural integrity of the NITY759 motif, rather than the phosphorylation status of Tyr759 is important for beta3-mediated cytoskeleton reorganization and tyrosine phosphorylation of FAK and paxillin, while the presence of Tyr at residue 747 within the NPLY747 motif is required for optimal beta3 post-ligand binding events. [less ▲]

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See detailInterleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
Heinrich, P. C.; Behrmann, Iris UL; Müller-Newen, G. et al

in Biochemical Journal (1998), 334 (Pt 2)

The family of cytokines signalling through the common receptor subunit gp130 comprises interleukin (IL)-6, IL-11, leukaemia inhibitory factor, oncostatin M, ciliary neurotrophic factor and cardiotrophin-1 ... [more ▼]

The family of cytokines signalling through the common receptor subunit gp130 comprises interleukin (IL)-6, IL-11, leukaemia inhibitory factor, oncostatin M, ciliary neurotrophic factor and cardiotrophin-1. These so-called IL-6-type cytokines play an important role in the regulation of complex cellular processes such as gene activation, proliferation and differentiation. The current knowledge on the signal-transduction mechanisms of these cytokines from the plasma membrane to the nucleus is reviewed. In particular, we focus on the assembly of receptor complexes after ligand binding, the activation of receptor-associated kinases of the Janus family, and the recruitment and phosphorylation of transcription factors of the STAT family, which dimerize, translocate to the nucleus, and bind to enhancer elements of respective target genes leading to transcriptional activation. The important players in the signalling pathway, namely the cytokines and the receptor components, the Janus kinases Jak1, Jak2 and Tyk2, the signal transducers and activators of transcription STAT1 and STAT3 and the tyrosine phosphatase SHP2 [SH2 (Src homology 2) domain-containing tyrosine phosphatase] are introduced and their structural/functional properties are discussed. Furthermore, we review various mechanisms involved in the termination of the IL-6-type cytokine signalling, namely the action of tyrosine phosphatases, proteasome, Jak kinase inhibitors SOCS (suppressor of cytokine signalling), protein inhibitors of activated STATs (PIAS), and internalization of the cytokine receptors via gp130. Although all IL-6-type cytokines signal through the gp130/Jak/STAT pathway, the comparison of their physiological properties shows that they elicit not only similar, but also distinct, biological responses. This is reflected in the different phenotypes of IL-6-type-cytokine knock-out animals. [less ▲]

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See detailTroisième espace de cohomologie de l'algèbre de Lie des opérateurs différentiels sur une variété à coefficients dans les fonctions
Poncin, Norbert UL

in Bulletin de la Société Royale des Sciences de Liège (1998), 67(6), 339--393

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See detail550 GHz bandwidth photodetector on low-temperature grown molecular-beam epitaxial GaAs
Kordoš, P.; Förster, A.; Marso, Michel UL et al

in Electronics Letters (1998), 34(1998), 119-120

The authors demonstrate that a 550GHz bandwidth photodetector can be fabricated on low-temperature grown MBE GaAs. The pulse response shows 0.4 and 0.6ps rise and fall times, respectively. The bandwidth ... [more ▼]

The authors demonstrate that a 550GHz bandwidth photodetector can be fabricated on low-temperature grown MBE GaAs. The pulse response shows 0.4 and 0.6ps rise and fall times, respectively. The bandwidth is in agreement with a value calculated using a carrier lifetime of 0.2ps, measured by femtosecond time-resolved reflectivity, and a capacitance of 0.014fF/um2, determined from microwave measurements. The device bandwidth is RC limited. [less ▲]

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See detailPax genes and organogenesis: Pax9 meets tooth development.
Peters, H.; Neubuser, A.; Balling, Rudi UL

in European Journal of Oral Sciences (1998), 106 Suppl 1

Pax genes encode a family of transcription factors that play key roles during embryogenesis. They are required for the development of a variety of organs including the nervous and muscular system ... [more ▼]

Pax genes encode a family of transcription factors that play key roles during embryogenesis. They are required for the development of a variety of organs including the nervous and muscular system, skeleton, eye, ear, kidney, thymus, and pancreas. Whereas the developmental roles of many of the nine known Pax genes have been analyzed in great detail, a functional analysis of Pax9 has just begun. During mouse embryogenesis, Pax9 exhibits a highly specific expression pattern in derivatives of the foregut endoderm, somites, limb mesenchyme, midbrain, and the cephalic neural crest. In the mandibular arch mesenchyme, the expression of Pax9 marks the prospective sites of tooth development prior to any morphological signs of odontogenesis and is maintained in the developing tooth mesenchyme thereafter. To understand the function of Pax9 during mouse embryogenesis, we recently have created a null allele by gene targeting. Preliminary analyses show that Pax9 is essential for the formation of teeth, and we conclude that Pax9 is required for tooth development to proceed beyond the bud stage. Here, we briefly summarize our current knowledge about Pax genes and introduce Pax9 to the growing family of factors which are involved in tooth development. [less ▲]

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See detailTwo years of continuous measurements of tidal and nontidal variations of gravity in Boulder, Colorado
van Dam, Tonie UL; Francis, Olivier UL

in Geophysical Research Letters (1998), 25(3), 393-396

We report here on the results of an analysis of 2 years of data from NOAA’s superconducting gravimeter located at the Table Mountain Gravity Observatory in Boulder, Colorado. Observed tidal parameters ... [more ▼]

We report here on the results of an analysis of 2 years of data from NOAA’s superconducting gravimeter located at the Table Mountain Gravity Observatory in Boulder, Colorado. Observed tidal parameters, corrected for ocean loading effects, are compared with theoretical tidal parameters predicted for a non-hydrostatic inelastic Earth model and demonstrate excellent agreement. Tidal residuals, corrected for polar motion and a linear instrument drift are highly correlated with gravity changes measured by two absolute gravimeters over the same time period. The admittance to local pressure i s found to be -0.356 mGal/mbar. However, this admittance factor is found to be seasonally and frequency dependent. Correlations between rainfall events and gravity changes are observed. Attempts to model these gravity changes as exponential functions of time were unsuccessful. [less ▲]

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See detailPrecommitment in Competing Vertical Chains
Irmen, Andreas UL

in Journal of Economic Surveys (1998), 12(4), 333-59

The design of distribution channels is an important marketing decision since a revision implies costly reorganization. Hence, it makes sense to study strategic motives of alternative distribution devices ... [more ▼]

The design of distribution channels is an important marketing decision since a revision implies costly reorganization. Hence, it makes sense to study strategic motives of alternative distribution devices. A precommitment is a strategic move that affects the other players' expectations on how oneself will behave and thus induces them to choose in one's own favor (Schelling, 1960). How these tactics can be used by firms to favorably influence competition between vertical chains is the topic of the literature reviewed in this survey. Copyright 1998 by Blackwell Publishers Ltd [less ▲]

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See detailLarge scale ENU screens in the mouse: genetics meets genomics.
Hrabe de Angelis, M.; Balling, Rudi UL

in Mutation research (1998), 400(1-2), 25-32

The worldwide effort to completely sequence the human and mouse genome will be accomplished within the next years. The focus of current activities within the framework of human genome research is mainly ... [more ▼]

The worldwide effort to completely sequence the human and mouse genome will be accomplished within the next years. The focus of current activities within the framework of human genome research is mainly on the assembly of high resolution genetic and physical maps and genomic sequencing. Cloning of new genes is getting more easy using those maps. Nevertheless, it is necessary to work on a systematic analysis of gene function. Results obtained from these efforts will be of enormous value for future biological and biomedical research. However, even the complete sequence will not in all cases reveal the molecular and cellular role of the different genes. Therefore, the next phase of the Human Genome Project will have at its core the functional analysis of genes. Those genes relevant for the diagnosis, prevention and therapy of human diseases are of particular interest. Looking at the history of life sciences, mutants have been the most important tool to obtain insight into the biological function of genes. The mouse is the model of choice for the study of inherited diseases in man. In order to meet the requirements for functional human genome analysis, we need a large number of mouse mutants similar to the collection of mutants available for other model organisms such as flys and worms. To fully apply the power of genetics, multiple alleles of the same gene such as hypomorphs or hypermorphs are required. Efficient production of mouse mutants showing specific phenotypes can be achieved by the use of ethylnitrosourea (ENU). ENU is the most powerful mutagen known and we currently see a renaissance of ENU mutagenesis. The application of ENU mutagenesis is reviewed and discussed in the context of a new era of functional genomics. [less ▲]

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See detailDewey in Europa. Paradoxen van modernisering in de onderwijsvernieuwing: een case study.
Biesta, Gert UL; Miedema, S.

in Nederlands Tijdschrift voor Opvoeding, Vorming en Onderwijs (1998), 14(6), 336-355

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See detailEinstellungen junger Deutscher gegenüber ausländischen Mitbürgern und ihre Bedeutung hinsichtlich politischer Orientierungen. Ausgewählte Ergebnisse des DJI-Jugendsurvey 1997
Kleinert, Corinna; Krüger, Winfried; Willems, Helmut UL

in Aus Politik und Zeitgeschichte (1998), 48.2(31), 14-27

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See detailDiscrete Logarithm Based Cryptosystems in Quadratic Function Fields of Charac­teristic 2
Müller, Volker UL; Vanstone, Scott; Zuccherato, Robert

in Designs, Codes and Cryptography (1998), 14(2), 159-178

We describe a public key cryptosystem which works in quadratic function fields of characteristic two. Formulas for arithmetic are explicitly giv­en. The security of the system is based on the discrete ... [more ▼]

We describe a public key cryptosystem which works in quadratic function fields of characteristic two. Formulas for arithmetic are explicitly giv­en. The security of the system is based on the discrete logarithm problem in these fields. Therefore we also describe a Discrete Logarithm algorithm based on the ideas of Pohlig and Hell­man, especially adopted to quadratic function fields of charac­teristic two. [less ▲]

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See detailChesapeake Bay subsidence monitored as wetlands loss continues
Nerem, R. S.; van Dam, Tonie UL; Schenewerk, M.

in EOS (1998), 79

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See detailInternalization of the interleukin 6 signal transducer gp130 does not require activation of the Jak/STAT pathway
Thiel, S.; Behrmann, Iris UL; Dittrich, E. et al

in Biochemical Journal (1998), 330 (Pt 1)

Signalling receptors often undergo receptor-mediated endocytosis. In many cases this internalization is stimulated by ligand binding and activation of intrinsic receptor tyrosine kinases, resulting in a ... [more ▼]

Signalling receptors often undergo receptor-mediated endocytosis. In many cases this internalization is stimulated by ligand binding and activation of intrinsic receptor tyrosine kinases, resulting in a receptor down-regulation. We have analysed whether internalization of the interleukin 6 signal transducer gp130 is dependent on the activation of receptor-associated Jak kinases. By using a chimaeric receptor system we found that receptor mutants that lack box1 and therefore are not capable of activating Jak and signal transducer and activator of transcription (STAT) proteins are still endocytosed efficiently. A chimaeric receptor with the recently identified dileucine internalization motif being replaced by two alanine residues was not efficiently internalized but still capable of recruiting STATs. Furthermore an antagonistic antibody that inhibits the signalling of all interleukin-6-type cytokines via gp130 was internalized as efficiently as an agonistic one that activates the Jak/STAT pathway. Our findings suggest that the endocytosis of gp130 is signal-independent. [less ▲]

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See detailMead, Intersubjectivity, and Education: The Early Writings.
Biesta, Gert UL

in Studies in Philosophy & Education (1998), 17

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See detailA locus for radiation-induced gastroschisis on mouse Chromosome 7.
Hillebrandt, S.; Streffer, C.; Montagutelli, X. et al

in Mammalian Genome (1998), 9(12), 995-7

Gastroschisis (abdominal wall defects) occurs with a high frequency in the mouse inbred strain HLG compared with C57BL/6J mice. The risk of gastroschisis increases significantly after exposure to ... [more ▼]

Gastroschisis (abdominal wall defects) occurs with a high frequency in the mouse inbred strain HLG compared with C57BL/6J mice. The risk of gastroschisis increases significantly after exposure to irradiation with X-rays during preimplantation development and follows a recessive mode of inheritance for the HLG susceptibility alleles. We have used a backcross strategy and genome-wide microsatellite typing to chromosomally map this trait. A suggestive linkage for a locus responsible for radiation-induced gastroschisis (Rigs1) was found in a region of mouse Chromosome 7. [less ▲]

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See detailHet is zoals het is en als ik kan helpen graag: Ervaringen van broers en zussen van kinderen met een lichamelijke handicap
Pit-Ten Cate, Ineke UL; Loots, G.M.P.

in Nederlands Tijdschrift voor Kinderrevalidatie (1998), (2), 33-37

Detailed reference viewed: 67 (0 UL)
See detailLa représentation en justice des personnes morales de droit public, note sous Cour administrative 15 janvier 1998
Ravarani, Georges UL

in Pasicrisie Luxembourgeoise: Recueil Trimestriel de la Jurisprudence Luxembourgeoise (1998), 30

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See detailLes transferts de données personnelles vers des pays tiers au regard de la directive européenne relative à la protection des personnes physiques à l'égard du traitement des données à caractère personnel et à la libre circulation des ces données (directive 95/46/CE du 24 octobre 1995)
Prüm, André UL

in Waseda Proceedings of Comparative Law (1998), 2

Les transferts de données personnelles vers des pays tiers au regard de la directive européenne relative à la protection des personnes physiques à l'égard du traitement des données à caractère personnel ... [more ▼]

Les transferts de données personnelles vers des pays tiers au regard de la directive européenne relative à la protection des personnes physiques à l'égard du traitement des données à caractère personnel et à la libre circulation des ces données (directive 95/46/CE du 24 octobre 1995) [less ▲]

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See detailA detailed analysis of tropospheric effects on geodetic observations at TMGO
Schenewerk, M.; van Dam, Tonie UL; Sasagawa, G. et al

in Physics and Chemistry of the Earth (1998), 23(1), 103-106

Improvements in geodetic tools are making previously subtle effects significant. Two examples affecting GPS observations are atmospheric loading of the Earth's crust and the tropospheric delays ... [more ▼]

Improvements in geodetic tools are making previously subtle effects significant. Two examples affecting GPS observations are atmospheric loading of the Earth's crust and the tropospheric delays, specifically the wet component. Each measurement, tropospheric delays and site coordinates, requires unambiguous determination of the other to achieve the highest accuracy. Table Mountain Geophysical Observatory (TMGO) is a unique site where a long history of observations from two complementary techniques, GPS and superconducting gravimetry, have been accrued. In particular, the superconducting gravity measurements provide a unique baseline for evaluating GPS vertical estimates over a variety of time frames. Positional estimates for TMGO using these techniques will be compared. Tropospheric effects will be identified and discussed. The ability for GPS to make subdaily, daily, and long term vertical estimates will be evaluated. [less ▲]

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See detailFast Multiplication on Elliptic Curves over Small Fields of Characteristic Two
Müller, Volker UL

in Journal of Cryptology (1998), 11(4), 219-234

The paper shows how Frobenius expansions can be used to speed up mul­tiplication of points on elliptic curves that are defined over very small fields of charac­teristic two. The Frobenius expansion ... [more ▼]

The paper shows how Frobenius expansions can be used to speed up mul­tiplication of points on elliptic curves that are defined over very small fields of charac­teristic two. The Frobenius expansion algorithm is analyzed in theory and in practice. It can gain significant improvements in practical applica­tions. These curves are there­fore especially interesting for implementations of elliptic curve cryptosystems. [less ▲]

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See detailTargeted disruption of Pax1 defines its null phenotype and proves haploinsufficiency.
Wilm, B.; Dahl, E.; Peters, H. et al

in Proceedings of the National Academy of Sciences of the United States of America (1998), 95(15), 8692-7

The murine paired box-containing gene Pax1 is required for normal development of the vertebral column, the sternum, and the scapula. Previous studies have shown that three natural Pax1 mouse mutants, the ... [more ▼]

The murine paired box-containing gene Pax1 is required for normal development of the vertebral column, the sternum, and the scapula. Previous studies have shown that three natural Pax1 mouse mutants, the undulated alleles, exhibit phenotypes of different severity in these skeletal elements. Nevertheless, these analyses have not clarified whether the semidominant Undulated short-tail (Uns) mutation, in which the complete Pax1 locus is deleted, represents a null allele. Moreover, the analyses of the classical undulated mutants did not allow a conclusion with respect to haploinsufficiency of Pax1. To address both questions we have created a Pax1 null allele in mice by gene targeting. Surprisingly, the phenotype of this defined mutation exhibits clear differences to that of Uns. This result strongly indicates the contribution of additional gene(s) to the Uns mutant phenotype. Furthermore, the phenotype of mice heterozygous for the null allele demonstrates that Pax1 is haploinsufficient in some though not all skeletal elements which express Pax1 during embryonic development. [less ▲]

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See detailOn nonstrict means
Fodor, János; Marichal, Jean-Luc UL

in Aequationes Mathematicae (1997), 54(3), 308-327

The general form of continuous, symmetric, increasing, idempotent solutions of the bisymmetry equation is established and the family of sequences of functions which are continuous, symmetric, increasing ... [more ▼]

The general form of continuous, symmetric, increasing, idempotent solutions of the bisymmetry equation is established and the family of sequences of functions which are continuous, symmetric, increasing, idempotent, decomposable is described. [less ▲]

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See detailThe pipecolate-incorporating enzyme for the biosynthesis of the immunosuppressant rapamycin: Nucleotide sequence analysis, disruption and heterologous expression of rapP from Streptomyces hygroscopicus.
König, Ariane UL; Schwecke, T.; Molnár, I. et al

in European Journal of Biochemistry (1997), 247(2), 526-534

An open reading frame (rapP) encoding the putative pipecolate-incorporating enzyme (PIE) has been identified in the gene cluster for the biosynthesis of rapamycin in Streptomyces hygroscopicus. Conserved ... [more ▼]

An open reading frame (rapP) encoding the putative pipecolate-incorporating enzyme (PIE) has been identified in the gene cluster for the biosynthesis of rapamycin in Streptomyces hygroscopicus. Conserved amino acid sequence motifs for ATP binding, ATP hydrolysis, adenylate formation, and 4'-phosphopantetheine attachment were identified by sequence comparison with authentic peptide synthetases. Disruption of rapP by phage insertion abolished rapamycin production in S. hygroscopicus, and the production of the antibiotic was specifically restored upon loss of the inserted phage by a second recombination event. rapP was expressed in both Escherichia coli and Streptomyces coelicolor, and recombinant PIE was purified to homogeneity from both hosts. Although low-level incorporation of [14C]beta-alanine into recombinant PIE isolated from E. coli was detected, formation of the covalent acylenzyme intermediate could only be shown with the PIE from S. coelicolor, suggesting that while the recombinant PIE from S. coelicolor was phosphopantetheinylated, only a minor proportion of the recombinant enzyme from E. coli was post-translationally modified. [less ▲]

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See detailCarte blanche - L"affaire Clabecq : légalisme contre légitimité ?
Corbisier, Isabelle UL

in Information & Documentation Juridiques (1997)

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See detailMark-up pricing and bilateral monopoly
Irmen, Andreas UL

in Economics Letters (1997), 54(2), 179-184

It is an empirically established fact that managers use cost based percentage margins when they price their goods. As a consequence, percentage mark-ups should be determined as equilibrium choices. This ... [more ▼]

It is an empirically established fact that managers use cost based percentage margins when they price their goods. As a consequence, percentage mark-ups should be determined as equilibrium choices. This paper incorporates this empirical observation into the analysis of competition among bilateral monopolists. [less ▲]

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See detailColor-Sensitive Photodetector Based on Porous Silicon Superlattices
Krüger, M.; Marso, Michel UL; Berger, M. G. et al

in Thin Solid Films (1997), 297(1997), 241-244

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See detailA Return to the Dewey-Russell Opposition.
Biesta, Gert UL

in [Review Essay] Culture & Psychology (1997), 3(1), 99-105

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See detailDer Grossvater Pestalozzis als pietistisch-pädagogischer Vermittler? Einleitung
Tröhler, Daniel UL

in Neue Pestalozzi-Blätter (1997), 3(1), 28-29

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See detailStructural and functional similarities between the human cytoskeletal protein zyxin and the ActA protein of Listeria monocytogenes.
Golsteyn, R. M.; Beckerle, M. C.; Koay, T. et al

in Journal of cell science (1997), 110 ( Pt 16)

The intracellular bacterial parasite Listeria monocytogenes produces ActA protein at its surface to facilitate the localized assembly of actin-filled comets that are required for movement. The ... [more ▼]

The intracellular bacterial parasite Listeria monocytogenes produces ActA protein at its surface to facilitate the localized assembly of actin-filled comets that are required for movement. The organization of actin in Listeria comets shows striking similarity to the organization of actin at the plasma membrane of mammalian cells. Therefore we examined the possibility that an ActA-like protein is present in mammalian cells. By using antibodies directed against ActA, we identified zyxin as an ActA related protein in a number of cell types. We compared the functions of ActA and zyxin by transient expression of variants tagged with an inner plasma membrane localization sequence (a CAAX box). Targeting of the proline rich domain of zyxin to the plasma membrane disrupts the actin cytoskeleton and cell shape in a manner similar to that which occurs with membrane-targeted ActA sequences. A chimeric protein composed of the N-terminal domain of ActA fused to the N-terminal and central domains of zyxin induced a full ActA response in cells. Furthermore, zyxin and ActA exhibit common protein partners in vitro. On the basis of the shared properties of zyxin and ActA, we propose that zyxin enhances actin organizing activity in mammalian cells. [less ▲]

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See detailBespreking van R.V. Arcilla, For the Love of Perfection.
Biesta, Gert UL

in Comenius (1997), 17(2), 168-171

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See detailAccuracy assessment of recent ocean tide models
Shum, C. K.; Woodworth, P. L.; Andersen, O. B. et al

in Journal of Geophysical Research (1997), 102(C11), 25173-25194

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See detailSequence analysis of the Methanococcus jannaschii genome and the prediction of protein function
Andrade, M.; Casari, G.; deDaruvar, A. et al

in Computer Applications in the Biosciences [=CABIOS] (1997), 13(4), 481-483

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See detailEffects of an acute inflammation on the proportion of CGRP- and SP-containing joint afferents
Hanesch, Ulrike UL; Heppelmann, Bernd

in Neuroscience Letters (1997), 233

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See detailGeometry-dependent scattering through ballistic microstructures: Semiclassical theory beyond the stationary-phase approximation
Wirtz, Ludger UL; Tang, J. Z.; Burgdorfer, J.

in Physical Review. B (1997), 56(12), 7589-7597

The conductance of a ballistic microstructure shows strong fluctuations as a function of the Fermi wave number. We present a semiclassical-theory that describes these fluctuations in terms of bundles of ... [more ▼]

The conductance of a ballistic microstructure shows strong fluctuations as a function of the Fermi wave number. We present a semiclassical-theory that describes these fluctuations in terms of bundles of short trajectories. These trajectories provide the dominant contribution to electron transport through a weakly open microstructure. For the coupling between the quantum wires and the cavity, contributions beyond the stationary phase approximation are taken into account giving rise to diffraction effects. A comparison with full quantum calculations for st rectangular billiard is made. The peak positions of the power spectrum agree very well between the quantum and semiclassical theories. Numerical evidence is found for the breakdown of the semiclassical approximation for long paths. A simple explanation in terms of the dispersion of the semiclassical wave packet in the interior of the cavity is proposed. [less ▲]

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See detailStaatliche Lehrerbildung in der Zeit der Helvetik und die Rolle Pestalozzis
Tröhler, Daniel UL

in Beiträge zur Lehrerbildung (1997), 15(3), 293-303

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See detailLire les "Recherches" de Pestalozzi
Tröhler, Daniel UL

in Bulletin du Centre de Documentation et de Recherche Pestalozzi (1997), (22), 24-28

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See detailSchule und Sport aus der Sicht jugendlicher Vereinsmitglieder - ein internationaler Vergleich
Steffgen, Georges UL; Schwenkmezger, Peter; Fröhling, Roland

in Sportunterricht (1997), 46(7), 292-300

The findings are presented of an international comparative study of youth sports club members to determine their perspectives on the relationship between school and sport, and the influence of physical ... [more ▼]

The findings are presented of an international comparative study of youth sports club members to determine their perspectives on the relationship between school and sport, and the influence of physical education on sport participation and membership of sports clubs. Participants in the study comprised two groups of 344 sports club members and school pupils from Luxembourg and Germany. Differences in terms of age, sex and school type were taken into account. The main findings indicate that school and physical education in both countries only have a slight, indirect influence on young people's decisions to become members of sports clubs and participate in sport. Indeed, the pressures of school may in some cases be an obstacle to intensive sports activity and training outside school. This is particularly so in Luxembourg where students often have to refuse participation in sports competitions and training because of the pressures of school work. Some final thoughts are presented on ways in which school and physical education could become more supportive of youth sport training and club membership, and could give greater encouragement to young people to succeed in competitive and high level sport. [less ▲]

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