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See detailRational promoter selection for gene transfer into cardiac cells.
Maass, Alexander; Langer, Stephen J.; Oberdorf-Maass, Silke et al

in Journal of Molecular and Cellular Cardiology (2003), 35(7), 823-31

Cardiomyocytes (CMCs) are extremely difficult to transfect with non-viral techniques, but they are efficiently infected by adenoviruses. The most commonly used promoters to drive protein expression in ... [more ▼]

Cardiomyocytes (CMCs) are extremely difficult to transfect with non-viral techniques, but they are efficiently infected by adenoviruses. The most commonly used promoters to drive protein expression in cardiac myocytes are of viral origin, since they are believed to be constitutively active and minimally regulated by physiological or pharmacological challenge of cells. In recombinant adenoviruses, we systematically compared three different promoters: the cytomegalovirus (CMV), the Rous sarcoma virus (RSV), and a synthetic promoter with three MEF2 transcription factor-binding sites upstream of the heat-shock protein 68 minimal promoter. We determined their basal activity in primary cardiac cells as well as their possible stimulation by commonly used agonists. The CMV promoter was activated up to 60-fold by the phorbol ester phorbol myristate acetate (PMA) and/or forskolin in neonatal rat CMCs and cardiac fibroblasts. Primary adult rat CMCs had higher basal expression from the CMV promoter that was not activated by PMA or forskolin. The RSV promoter was less affected by agonists and was more active in cardiac myocytes compared to cardiac fibroblasts. The MEF2-responsive promoter showed high basal expression in both myocytes and fibroblasts, and minimal induction by phorbol esters and forskolin. The relevance of reporter gene induction was confirmed with a contractile protein, troponin T (TnT). The CMV promoter driving TnT could be induced more than 15-fold with phenylephrine or forskolin to replace the endogenous protein almost to completion at a multiplicity of infection of 10. These results suggest the following use of the tested promoters: an inducible system (CMV), a myocyte-enriched system (RSV), or a stable control system (MEF2). [less ▲]

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See detailCorruption and Related Crimes in International Business Activities, Hungarian National Report
Ligeti, Katalin UL

in Revue Internationale de Droit Pénal (2003)

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See detailLes interventions de Philippe de Marnix aux assemblées impériales. Augsbourg 1566 – Spire 1570 – Worms 1578
Weis, Monique UL

in Bulletin de la Société royale d’histoire du protestantisme belge (2003), 132

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See detailAdaptive tests of qualitative hypotheses
Baraud, Yannick UL; Huet, Sylvie; Laurent, Béatrice

in ESAIM: Probability and Statistics (2003), 7

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See detailÉtude critique de la notion de patrimoine en droit privé actuel
Hiez, David UL

in Bibliothèque de droit privé (2003), 399

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See detailPrinciples of interleukin (IL)-6-type cytokine signalling and its regulation
Heinrich, P. C.; Behrmann, Iris UL; Haan, Serge UL et al

in Biochemical Journal (2003), 374(Pt 1), 1-20

The IL (interleukin)-6-type cytokines IL-6, IL-11, LIF (leukaemia inhibitory factor), OSM (oncostatin M), ciliary neurotrophic factor, cardiotrophin-1 and cardiotrophin-like cytokine are an important ... [more ▼]

The IL (interleukin)-6-type cytokines IL-6, IL-11, LIF (leukaemia inhibitory factor), OSM (oncostatin M), ciliary neurotrophic factor, cardiotrophin-1 and cardiotrophin-like cytokine are an important family of mediators involved in the regulation of the acute-phase response to injury and infection. Besides their functions in inflammation and the immune response, these cytokines play also a crucial role in haematopoiesis, liver and neuronal regeneration, embryonal development and fertility. Dysregulation of IL-6-type cytokine signalling contributes to the onset and maintenance of several diseases, such as rheumatoid arthritis, inflammatory bowel disease, osteoporosis, multiple sclerosis and various types of cancer (e.g. multiple myeloma and prostate cancer). IL-6-type cytokines exert their action via the signal transducers gp (glycoprotein) 130, LIF receptor and OSM receptor leading to the activation of the JAK/STAT (Janus kinase/signal transducer and activator of transcription) and MAPK (mitogen-activated protein kinase) cascades. This review focuses on recent progress in the understanding of the molecular mechanisms of IL-6-type cytokine signal transduction. Emphasis is put on the termination and modulation of the JAK/STAT signalling pathway mediated by tyrosine phosphatases, the SOCS (suppressor of cytokine signalling) feedback inhibitors and PIAS (protein inhibitor of activated STAT) proteins. Also the cross-talk between the JAK/STAT pathway with other signalling cascades is discussed. [less ▲]

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See detailExplicit formulae for time-space Brownian chaos
Peccati, Giovanni UL

in Bernoulli (2003), 9(1), 25--48

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See detailL’incidence du lieu d’exécution du contrat sur la loi applicable
Cuniberti, Gilles UL

in La Semaine Juridique Edition Générale (2003)

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See detailInternationalisierung und nationale Kontexte der Forschung
Tröhler, Daniel UL

in Zeitschrift für Pädagogische Historiographie (2003), 9(1), 31-33

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See detailJVirGel: calculation of virtual two-dimensional protein gels
Hiller, Karsten UL; Schobert, Max; Hundertmark, Claudia et al

in Nucleic Acids Research (2003)

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See detailAb initio calculations of the lattice dynamics of boron nitride nanotubes
Wirtz, Ludger UL; Rubio, A.; de la Concha, R. A. et al

in Physical Review. B (2003), 68(4),

We present an extensive first-principles study of the phonons in boron nitride nanotubes using density functional perturbation theory in the local density approximation. Based on the nonsymmorphic rod ... [more ▼]

We present an extensive first-principles study of the phonons in boron nitride nanotubes using density functional perturbation theory in the local density approximation. Based on the nonsymmorphic rod-group symmetry of the tubes, the Raman- and infrared-active modes at the Gamma point of the one-dimensional Brillouin zone are evaluated. For zigzag and chiral nanotubes, the set of infrared-active modes is a subset of the Raman- active modes. In particular, the radial breathing mode is not only Raman but also infrared active. However, for armchair tubes, the sets of infrared-and Raman- active modes are disjoint. This may serve to spectroscopically distinguish between macroscopic samples of zigzag-chiral and armchair nanotubes. We present the frequencies of the active modes of zigzag, chiral, and armchair tubes as a function of the tube diameter and compare the results with the frequencies obtained by the zone-folding method, i.e., the rolling of a single hexagonal BN sheet into a tube. Except for the high-frequency tangential modes, the zone-folding results are in very good agreement with the ab initio calculations. The radial breathing mode frequency can be derived by folding a sheet of finite width. Finally, we show that the effects of bundling on the phonon frequencies are small. This demonstrates that the obtained results for isolated BN tubes may serve as a basis for an accurate assignment of phonon modes in spectroscopic measurements. [less ▲]

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See detailMort lente de l'interdiction de rémunérer les comptes à vue
Prüm, André UL

in Revue de Droit Bancaire et Financier (2003), (2),

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See detailHaploinsufficiency at the alpha-synuclein gene underlies phenotypic severity in familial Parkinson's disease.
Kobayashi, Hirokazu; Krüger, Rejko UL; Markopoulou, Katerina et al

in Brain : a journal of neurology (2003), 126(Pt 1), 32-42

To date, two point mutations, G209A and G88C, have been reported in the coding region of the alpha-synuclein gene in autosomal dominant familial Parkinson's disease. When translated, these lead to the ... [more ▼]

To date, two point mutations, G209A and G88C, have been reported in the coding region of the alpha-synuclein gene in autosomal dominant familial Parkinson's disease. When translated, these lead to the missense mutations Ala53Thr and Ala30Pro, respectively. Reduced mRNA expression of the G209A allele was reported recently in a Greek-American family. Here, we show that alpha-synuclein mRNA is normally expressed in blood cells and report the results of an analysis of alpha-synuclein mRNA and protein expression in lymphoblastoid cell lines established from kindreds with the G209A and G88C mutations. mRNA expression was characterized using a TaqMan real-time quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) assay. We assessed five affected and three unaffected members of a German family with the G88C mutation and two affected members in different, unrelated Greek families with the G209A mutation. The ratio of wild-type to mutant alpha-synuclein allele expression ranged from 2.2 to 9.2 in the affected individuals with a severe clinical phenotype. The ratios of the expression levels of the wild-type to mutant alleles were only slightly decreased in mild cases and were less than 1.0 in two asymptomatic heterozygotes. Sequence analysis of the RT-PCR products showed only the presence of G in position 88 and G in position 209 in severely affected heterozygotes of the German and Greek families, respectively. High performance liquid chromatography/mass spectrometry demonstrated that, relative to wild-type alpha-synuclein, there is a reduction of Ala30Pro alpha-synuclein in lymphoblastoid cell lines originating from severely affected, but not mildly affected G88C/+ heterozygotes. Taken together, these data indicate that there is haploinsufficiency at the alpha-synuclein gene and that the ratio of expression of the wild-type to mutant alleles correlates with the severity of the clinical phenotype. Furthermore, these findings suggest that haploinsufficiency of alpha-synuclein mutations may contribute to disease progression in these forms of familial Parkinson's disease. [less ▲]

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See detailInflation, Factor Substitution and Growth
Klump, Rainer UL

in Kredit und Kapital (2003)

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See detailRange of magnetic correlations in nanocrystalline soft magnets
Michels, Andreas UL; Viswanath, R. N.; Barker, J. G. et al

in Physical Review Letters (2003), 91

We have obtained the magnetic field dependence of static ferromagnetic correlations in nanocrystalline electrodeposited Co and Ni by means of the correlation function of the spin misalignment, determined ... [more ▼]

We have obtained the magnetic field dependence of static ferromagnetic correlations in nanocrystalline electrodeposited Co and Ni by means of the correlation function of the spin misalignment, determined from small-angle neutron scattering data. The approach yields a correlation length lC, which is a measure for the spatial extent of inhomogeneities in the magnetization distribution. The correlation length depends strongly on the applied magnetic field with values ranging from 94 nm in nanocrystalline Co at low fields to about 15 nm at saturation. The results for lC indicate that in Co the main source of nonuniformity in the spin system is the anisotropy field of each individual crystallite, whereas in nanocrystalline Ni the main sources of spin disorder originate from twin faults or from the defect cores of grain boundaries. [less ▲]

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See detailWet low-temperature gate oxidation for nanoscale vertical field-effect transistors,
Goryll, M.; Moers, J.; Trellenkamp, S. et al

in Physica E: Low-Dimensional Systems and Nanostructures (2003), 19(2003), 18-22

In this work, we present an approach towards improving a vertical eld-e ect transistor based on a narrow mesa that is capable of showing complete channel inversion. Contrary to similar concepts it does ... [more ▼]

In this work, we present an approach towards improving a vertical eld-e ect transistor based on a narrow mesa that is capable of showing complete channel inversion. Contrary to similar concepts it does not necessarily require the use of an SOI substrate due to the chosen vertical layer sequence. An important issue during process flow is the limited thermal budget in order to preserve the desired channel length. Here a low-temperature wet oxidation process is investigated to prevent dopant di ffusion in early process steps. Results on the thickness homogeneity and electrical properties of this gate oxide will be presented and discussed. [less ▲]

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See detailForschungsprojekt Frühfranzösisch an der Universität des Saarlandes: Code-switching im Sprachunterricht anhand von Beispielen aus dem Projektcorpus "Effizienz des Frühunterrichts Französisch in saarländischen Schulen". Wie funktioniert Code-switching bei Schülern und Lehrern in der Interaktion im Unterricht?
Ehrhart, Sabine UL

in Zeitschrift für Angewandte Linguistik (2003), 39

Even though the important role of early institutional language teaching has been proved by numerous studies, the practical applications of these findings are still very rare. In the Saarland, one of the ... [more ▼]

Even though the important role of early institutional language teaching has been proved by numerous studies, the practical applications of these findings are still very rare. In the Saarland, one of the German Laender which is situated on the border with France, a pilote project examinates the learning behaviour and mechanism with German primary school children learning French, their neighbouring language, from age 6 on. The author is the coordinator of the scientific team which follows the project from a universitarian point of view. The aim of the paper is to show the important role code-switching plays in this kind of teaching environment and it tries to evaluate its importance by giving examples from different stages of progress during the first two years of learning. [less ▲]

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See detailNaStraG - ein erster Schritt in Richtung Virtuelle Hauptversammlung für Namens- und Inhaberaktien
Zetzsche, Dirk Andreas UL

in Zeitschrift für Wirtschaftsrecht (2003)

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See detailQuels sont les objectifs éducatifs privilégiés par les familles
Poncelet, Débora UL

in Scientia Paedagogica Experimentalis (2003), 40(1), 29-46

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See detailDécision de la Cour de Justice des Communautés européennes, Dijon, 23 avril 2002
Cuniberti, Gilles UL

in Clunet (2003)

Effet de titre des sentences arbitrales.

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See detailBeta3 integrins: major therapeutic targets of the near future.
Schaffner-Reckinger, Elisabeth UL

in Bulletin de la Société des Sciences Médicales du Grand-Duché de Luxembourg (2003), (1), 23-34

Integrins are major cell adhesion receptors which assume two important functions: first they act as anchoring molecules allowing firm cellular attachment to the extracellular matrix, and second they work ... [more ▼]

Integrins are major cell adhesion receptors which assume two important functions: first they act as anchoring molecules allowing firm cellular attachment to the extracellular matrix, and second they work as signalling receptors being able to transduce signals in both directions (outside-in and inside-out) through the plasma membrane. Their biological importance is determined by their involvement in many physiological phenomena. Furthermore, their implication in various diseases and their accessibility to drugs make them interesting therapeutic targets. [less ▲]

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See detailGlobal deformations of the Witt algebra of Krichever-Novikov type
Fialowski, Alice; Schlichenmaier, Martin UL

in Communications in Contemporary Mathematics (2003), 5(6), 921-946

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See detailL'autolimitation implicite des normes de droit privé matériel
Kinsch, Patrick UL

in Revue Critique de Droit International Privé (2003)

L'autolimitation des normes de droit matériel doit être distinguée du jeu des mécanismes du droit international privé, spécialement du jeu des règles de conflit. Elle correspond à la définition, par ... [more ▼]

L'autolimitation des normes de droit matériel doit être distinguée du jeu des mécanismes du droit international privé, spécialement du jeu des règles de conflit. Elle correspond à la définition, par certaines règles de droit matériel, de leur propre champ d'application international et n'intervient qu'à condition que le droit applicable aux termes des règles de conflit de lois soit préalablement connu. La présente contribution examine les cas dans lesquels l'autolimitation d'une norme de droit matériel n'est pas l'effet d'une disposition législative expresse, mais de l'interprétation de la norme par les tribunaux: incidence de la « présomption contre l'extraterritorialité » des normes législatives dans les pays de common law, autolimitation des lois de police, emploi par la norme de notions fermées à toute substitution... On verra ainsi apparaître le phénomène de l'autolimitation des normes comme une illustration, parmi d'autres, de la contribution des normes de droit matériel à la réglementation des situations internationales. [less ▲]

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See detailForschungsprojekt Frühfranzösisch an der Universität des Saarlandes. Code-switching im Sprachunterrricht anhand von Beispielen aus dem Projektcorpus “Effizienz des Frühunterrichts Französisch in saarländischen Schulen“. Wie funktioniert code-switching bei Schülern und Lehrern in der Interaktion im Unterricht?
Ehrhart, Sabine UL

in Zeitschrift für Angewandte Linguistik (2003), 39

Even though the important role of early institutional language teaching has been proved by numerous studies, the practical applications of these findings are still very rare. In the Saarland, one of the ... [more ▼]

Even though the important role of early institutional language teaching has been proved by numerous studies, the practical applications of these findings are still very rare. In the Saarland, one of the German Laender which is situated on the border with France, a pilote project examinates the learning behaviour and mechanism with German primary school children learning French, their neighbouring language, from age 6 on. The author is the coordinator of the scientific team which follows the project from a universitarian point of view. The aim of the paper is to show the important role code-switching plays in this kind of teaching environment and it tries to evaluate its importance by giving examples from different stages of progress during the first two years of learning [less ▲]

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See detailEffect of surface passivation on performance of AlGaN/GaN/Si HEMTs
Bernát, J.; Javorka, P.; Fox, A. et al

in Solid-State Electronics (2003), 47((2003)), 2097-2103

Performance of intentionally undoped and doped AlGaN/GaN/Si high electron mobility transistors (HEMTs) before and after passivation with SiO2 and Si3N4 is investigated. Hall effect measurements show ... [more ▼]

Performance of intentionally undoped and doped AlGaN/GaN/Si high electron mobility transistors (HEMTs) before and after passivation with SiO2 and Si3N4 is investigated. Hall effect measurements show higher impact of Si3N4 than SiO2 passivation on the carrier concentration increase in the channel. Improvements in DC performance of HEMTs after passivation with SiO2 and Si3N4 correspond to the changes in sheet carrier concentration. Small signal microwave characterisation shows a decrease (from 18.6 to 9 GHz) and an increase (from 18.4 to 28.8 GHz) of the current gain cut off frequency after SiO2 and Si3N4 passivation, respectively. Similar effect of passivation is found in microwave power changes––only about a half of the power is obtained after SiO2 passivation but more than doubled power results from Si3N4 passivation, measured at 2 GHz. Higher density of interface states for SiO2 than Si3N4 passivation is supposed to be responsible for these effects. However, for an optimal design of GaN-based power devices additional studies related to the interface between a passivation layer and GaN are needed. [less ▲]

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See detailTherapeutic strategies for Parkinson's disease based on data derived from genetic research.
Riess, Olaf; Berg, Daniela; Krüger, Rejko UL et al

in Journal of neurology (2003), 250 Suppl 1

Following the identification of mutations in alpha-synuclein as the cause of some rare forms of familial Parkinson's disease (PD), genetic research has uncovered numerous gene loci of PD. Meanwhile ... [more ▼]

Following the identification of mutations in alpha-synuclein as the cause of some rare forms of familial Parkinson's disease (PD), genetic research has uncovered numerous gene loci of PD. Meanwhile, several neurodegenerative diseases have been shown to accumulate a-synuclein in neuronal and glial cells summarizing this group of diseases as synucleinopathies. All currently known gene defects causing PD alter the ubiquitin-proteasomal pathway of protein degradation. Identification of these disease mutations allows studying the functional consequences which lead to cellular dysfunction and cell death in cell culture and transgenic animal models, to identify therapeutic targets and to test potential protective strategies in these models. [less ▲]

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See detailL2-gain of double integrators with saturation nonlinearity
Goncalves, Jorge UL

in IEEE Transactions on Automatic Control (2002), 47(12), 2063-2068

This note uses quadratic surface Lyapunov functions (SuLFs) to efficiently check if a double integrator in feedback with a saturation nonlinearity has L -gain less than > 0. We show that for many such ... [more ▼]

This note uses quadratic surface Lyapunov functions (SuLFs) to efficiently check if a double integrator in feedback with a saturation nonlinearity has L -gain less than > 0. We show that for many such systems, the L -gain is nonconservative in the sense that this is approximately equal to the lower bound obtained by replacing the saturation with a constant gain of 1. These results allow the use of classical analysis tools like -analysis or integral quadratic constraints to analyze systems with double integrators and saturations, including servo systems like some mechanical systems, satellites, hard disks, compact disk players, etc. [less ▲]

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See detailOn order invariant synthesizing functions
Marichal, Jean-Luc UL

in Journal of Mathematical Psychology (2002), 46(6), 661-676

This paper gives a description of the class of continuous functions that are comparison meaningful in the sense of measurement theory. When idempotency is assumed, this class reduces to the Boolean max ... [more ▼]

This paper gives a description of the class of continuous functions that are comparison meaningful in the sense of measurement theory. When idempotency is assumed, this class reduces to the Boolean max-min functions (lattice polynomials). In that case, continuity can be replaced by increasing monotonicity, provided the range of variables is open. The particular cases of order statistics and projection functions are also studied. [less ▲]

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See detailLa formación y promoción de las nuevas generaciones de científicos del deporte en Alemania
Bund, Andreas UL

in Educación física Chile (2002), 258

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See detailAspectos psicólogicos del entrenamiento de los deportistas juveniles
Bund, Andreas UL

in Educación Física y Deporte (2002), 22

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See detailMöglichkeiten der Drittmittelfinanzierung von Promotionen
Bund, Andreas UL

in Ze-phir : Informationen für den Sportwissenschaftlichen Nachwuchs (2002)

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See detailAbweichendes Verhalten
Willems, Helmut UL

in Kölner Zeitschrift für Soziologie und Sozialpsychologie (2002), 54(3), 590-591

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See detailAllpass Delay Chain-Based IIR PR Filterbank and Its Application to Multiple Description Subband Coding
Shankar, Bhavani UL; Makur, Anamitra

in IEEE Transactions on Signal Processing (2002), (4), 814-823

A class of infinite impulse response (IIR) perfect reconstruction (PR) filterbank is obtained with an allpass delay chain and finite impulse response (FIR) matrices at the analysis side. Such a ... [more ▼]

A class of infinite impulse response (IIR) perfect reconstruction (PR) filterbank is obtained with an allpass delay chain and finite impulse response (FIR) matrices at the analysis side. Such a formulation leads to a filterbank that can be optimized to any desired response. For a first-order allpass, the synthesis bank becomes FIR. Design examples showing warping of the frequency scale and filters with unequal passband widths are presented. The latter part of the work deals with designing a filterbank for a multiple description coding scenario. This is achieved in two parts: by obtaining the MMSE synthesis bank for a given analysis bank and channel state and by optimizing the analysis response to minimize the average distortion in the presence of channel erasures and quantization. The proposed IIR filterbank, as well as the well-known FIR paraunitary filterbank, are optimized for various channels, and their performances for the two-channel case have been compared with the derived optimal performance [less ▲]

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See detailEntropy of discrete Choquet capacities
Marichal, Jean-Luc UL

in European Journal of Operational Research (2002), 137(3), 612-624

We introduce a measure of entropy for any discrete Choquet capacity and we interpret it in the setting of aggregation by the Choquet integral.

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See detailSpectrum of phenotypes and genotypes in Parkinson's disease.
Riess, Olaf; Krüger, Rejko UL; Schulz, Jorg B.

in Journal of neurology (2002), 249 Suppl 3

The pathogenesis of Parkinsons disease (PD) is currently unknown. Environmental and genetic factors might contribute to the neurodegenerative process. Genetic mapping approaches in rare familial cases ... [more ▼]

The pathogenesis of Parkinsons disease (PD) is currently unknown. Environmental and genetic factors might contribute to the neurodegenerative process. Genetic mapping approaches in rare familial cases with autosomal recessive and autosomal dominant inheritance of PD suggest wide genetic heterogeneity of the disease. These gene loci in turn allow now a more specific clinical investigation of affected families to study the clinical heterogeneity of PD. The recent identification of mutations in three genes involved in protein degradation and aggregation in familial PD does now facilitate the deciphering of other genes involved in the pathogenesis of the disease. [less ▲]

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See detailPanorama de jurisprudence en matière d'indemnisation du dommage mise à jour 2002.
Ravarani, Georges UL

in Pasicrisie Luxembourgeoise: Recueil Trimestriel de la Jurisprudence Luxembourgeoise (2002), 31

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See detailBeethoven, a mouse model for dominant, progressive hearing loss DFNA36.
Vreugde, Sarah; Erven, Alexandra; Kros, Corne J. et al

in Nature Genetics (2002), 30(3), 257-8

Despite recent progress in identifying genes underlying deafness, there are still relatively few mouse models of specific forms of human deafness. Here we describe the phenotype of the Beethoven (Bth ... [more ▼]

Despite recent progress in identifying genes underlying deafness, there are still relatively few mouse models of specific forms of human deafness. Here we describe the phenotype of the Beethoven (Bth) mouse mutant and a missense mutation in Tmc1 (transmembrane cochlear-expressed gene 1). Progressive hearing loss (DFNA36) and profound congenital deafness (DFNB7/B11) are caused by dominant and recessive mutations of the human ortholog, TMC1 (ref. 1), for which Bth and deafness (dn) are mouse models, respectively. [less ▲]

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See detailWetting in ternary mixtures - with and without amphiphiles
Schilling, Tanja UL; Gompper, G.

in Journal of Chemical Physics (2002), 117(15), 7284-7294

The interfacial wetting behavior of ternary fluid mixtures is investigated, both for systems where all components have isotropic interaction potentials, as well as for systems where one component is an ... [more ▼]

The interfacial wetting behavior of ternary fluid mixtures is investigated, both for systems where all components have isotropic interaction potentials, as well as for systems where one component is an amphiphile. The BEG model and the corresponding two-order-parameter Ginzburg–Landau model are employed for systems without amphiphiles. We calculate the global wetting phase diagram for nonamphiphilic mixtures. In the investigated range of interaction parameters, the wetting transitions are always continuous at three-phase coexistence. The critical behavior is found to be universal in some, nonuniversal in other parts of the phase diagram. For systems with amphiphiles, two additional interaction terms are taken into account. The first models the aggregation of amphiphilic molecules at the air–water interface, the second the formation of amphiphilic bilayers in water. We find that the first term leads to a reduction of the tension of the air–water interface, and favors wetting by the water-rich phase, while the second—bilayer—term leads to a reduction of the tension of the interface between the water-rich and amphiphile-rich phases. [less ▲]

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See detailIst das Gedächtnis für klinisch-diagnostische Personmerkmale abhängig vom Verarbeitungsziel?
Krolak-Schwerdt, Sabine UL; le Coutre, Christine

in Psychologische Beiträge (2002), 44(3), 428-446

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See detailCalcineurin in human heart hypertrophy.
Ritter, Oliver; Hack, Susanne; Schuh, Kai et al

in Circulation (2002), 105(19), 2265-9

BACKGROUND: In animal models, increased signaling through the calcineurin pathway has been shown to be sufficient for the development of cardiac hypertrophy. Calcineurin activity has been reported to be ... [more ▼]

BACKGROUND: In animal models, increased signaling through the calcineurin pathway has been shown to be sufficient for the development of cardiac hypertrophy. Calcineurin activity has been reported to be elevated in the myocardium of patients with congestive heart failure. In contrast, few data are available about calcineurin activity in patients with pressure overload or cardiomyopathic hypertrophy who are not in cardiac failure. METHODS AND RESULTS: We investigated calcineurin activity and protein expression in 2 different forms of cardiac hypertrophy: hypertrophic obstructive cardiomyopathy (HOCM) and aortic stenosis (AS). We found that the C-terminus of calcineurin A protein containing the autoinhibitory domain was less abundant in myocardial hypertrophy than in normal heart, which suggests the possibility of proteolysis. No new splice variants could be detected by reverse-transcription polymerase chain reaction. This resulted in a significant elevation of calcineurin enzymatic activity in HOCM and AS compared with 6 normal hearts. Increased calcineurin phosphatase activity caused increased migration of NF-AT2 (nuclear factor of activated T cells 2) in SDS-PAGE compatible with pronounced NF-AT dephosphorylation in hypertrophied myocardial tissue. CONCLUSIONS: Hypertrophy in HOCM and AS without heart failure is characterized by a significant increase in calcineurin activity. This might occur by (partial) proteolysis of the calcineurin A C-terminus containing the autoinhibitory domain. Increased calcineurin activity has functional relevance, as shown by altered NF-AT phosphorylation state. Although hypertrophy in AS and HOCM may be initiated by different upstream triggers (internal versus external fiber overload), in both cases, there is activation of calcineurin, which suggests an involvement of this pathway in the pathogenesis of human cardiac hypertrophy. [less ▲]

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See detailFunctional organization of the yeast proteome by systematic analysis of protein complexes.
Gavin, Anne-Claude; Bosche, Markus; Krause, Roland UL et al

in Nature (2002), 415(6868), 141-7

Most cellular processes are carried out by multiprotein complexes. The identification and analysis of their components provides insight into how the ensemble of expressed proteins (proteome) is organized ... [more ▼]

Most cellular processes are carried out by multiprotein complexes. The identification and analysis of their components provides insight into how the ensemble of expressed proteins (proteome) is organized into functional units. We used tandem-affinity purification (TAP) and mass spectrometry in a large-scale approach to characterize multiprotein complexes in Saccharomyces cerevisiae. We processed 1,739 genes, including 1,143 human orthologues of relevance to human biology, and purified 589 protein assemblies. Bioinformatic analysis of these assemblies defined 232 distinct multiprotein complexes and proposed new cellular roles for 344 proteins, including 231 proteins with no previous functional annotation. Comparison of yeast and human complexes showed that conservation across species extends from single proteins to their molecular environment. Our analysis provides an outline of the eukaryotic proteome as a network of protein complexes at a level of organization beyond binary interactions. This higher-order map contains fundamental biological information and offers the context for a more reasoned and informed approach to drug discovery. [less ▲]

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See detailTruncation mutations in ABCA1 suppress normal upregulation of full-length ABCA1 by 9-cis-retinoic acid and 22-R-hydroxycholesterol
Wellington, C. L.; Yang, Y. Z.; Zhou, S. et al

in Journal of Lipid Research (2002), 43(11), 1939-1949

Mutations in ABCA1 uniformly decrease plasma HDL-cholesterol (HDL-C) and reduce cholesterol efflux, yet different mutations in ABCA1 result in different phenotypic effects in heterozygotes. For example ... [more ▼]

Mutations in ABCA1 uniformly decrease plasma HDL-cholesterol (HDL-C) and reduce cholesterol efflux, yet different mutations in ABCA1 result in different phenotypic effects in heterozygotes. For example, truncation mutations result in significantly lower HDL-C and apoliprotein A-I (apoA-I) levels in heterozygotes compared with nontruncation mutations, suggesting that truncation mutations may negatively affect the wild-type allele. To specifically test this hypothesis, we examined ABCA1 protein expression in response to 9-cis-retinoic acid (9-cis-RA) and 22-R-hydroxycholesterol (22-R-OH-Chol) in a collection of human fibroblasts representing eight different mutations and observed that truncation mutations blunted the response to oxysterol stimulation and dominantly suppressed induction of the remaining full-length allele to 5–10% of wild-type levels. mRNA levels between truncation and nontruncation mutations were comparable, suggesting that ABCA1 expression was suppressed at the protein level. Dominant negative activity of truncated ABCA1 was recapitulated in an in vitro model using transfected Cos-7 cells. Our results suggest that the severe reduction of HDL-C in patients with truncation mutations may be at least partly explained by dominant negative suppression of expression and activity of the remaining full-length ABCA1 allele. [less ▲]

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See detailVergleichsprozesse in der Auseinandersetzung mit schweren körperlichen Erkrankungen.
Filip, Sigrun-Heide; Ferring, Dieter UL

in Psychotherapie im Dialog (2002), 3(1)

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See detailLa R\&D au niveau des entreprises belges: une approche spatiale
Bertinelli, Luisito UL; Nicolini, Rosella

in Brussels Economic Review (2002), 45(4), 187-216

The main aim of this study is to analyse the spatial distribution of R\&D activity, as well as to measure whether this distribution has any impact on the location decision of innovating firms. To that ... [more ▼]

The main aim of this study is to analyse the spatial distribution of R\&D activity, as well as to measure whether this distribution has any impact on the location decision of innovating firms. To that extent, we work on firm level data. The first approach allows us to give an instantaneous representation of the spatial distribution of R\&D activity, for each sector. Clusters of R\&D activity appear to provide strong incentives for further investments in R\&D, in the same sector as well as in the same area. Moreover, our analysis allows us to measure how geographic proximity helps firms benefiting from localization/urbanization economies. Some further policy implications conclude the paper. [less ▲]

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See detailL’influence du sexe sur les variables conatives et sur la performance illustrée par l’exemple des mathématiques.
Kerger, Sylvie UL

in Psychologie différentielle : recherches et réflexions (2002)

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See detailWhen writing 0 (zero) is easier than writing O (o): a neuropsychological case study of agraphia.
Delazer, M.; Lochy, Aliette UL; Jenner, C. et al

in Neuropsychologia (2002), 40(12), 2167-77

Though a few case studies reported a dissociation between intact writing of Arabic and impaired writing of alphabetical script, a detailed experimental analysis of such a dissociation is still lacking. We ... [more ▼]

Though a few case studies reported a dissociation between intact writing of Arabic and impaired writing of alphabetical script, a detailed experimental analysis of such a dissociation is still lacking. We report a follow-up study of a patient with a parieto-occipital lesion who is affected by severe peripheral agraphia for letters, but not for Arabic digits. While letters in writing to dictation are frequently illegible, distorted, or consist in meaningless strokes, Arabic digits are well-formed and fluently produced. In a series of tasks, including copying of letters with tachistoscopic presentation and handwriting on a digitizing tablet, several processing levels are assessed in order to localize JS' functional writing impairment and to determine different processing routes for letters and for numbers. Overall, the results of the experimental investigation suggest a notation specific deficit in the activation of graphomotor patterns for letters, but not for digits. The study thus adds evidence to the so far reported dissociations between Arabic and alphabetical scripts. [less ▲]

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See detailGenetic and molecular control of folate-homocysteine metabolism in mutant mice.
Ernest, Sheila; Christensen, Benedicte; Gilfix, Brian M. et al

in Mammalian Genome (2002), 13(5), 259-67

Hyperhomocysteinemia adversely affects fundamental aspects of fetal development, adulthood, and aging, but the role of elevated homocysteine levels in these birth defects and adult diseases remains ... [more ▼]

Hyperhomocysteinemia adversely affects fundamental aspects of fetal development, adulthood, and aging, but the role of elevated homocysteine levels in these birth defects and adult diseases remains unclear. Mouse models are valuable for investigating the causes and consequences of hyperhomocysteinemia. We used a phenotype-based approach to identify mouse mutants for studying the relation between single gene mutations, homocysteine levels as a measure of the status of homocysteine metabolism, and gene expression profiles as a way to assess the impact of protein deficiency in mutant mice on steady-state transcription levels of genes in the folate-homocysteine pathways. These mutants were selected based on their propensity to produce phenotypes that are reminiscent of those associated with anomalies in folate-homocysteine metabolism in humans. We report identification of new, single-gene mouse models of homocysteinemia and characterization of their molecular and physiological impact on folate-homocysteine metabolism. Mutations in several genes involved in the hedgehog and WNT signal transduction pathways, as well as a gene involved in lipid metabolism, resulted in elevated homocysteine levels and altered expression profiles of folate-homocysteine metabolism genes. These results begin to unravel the complex relations between elevation of a single amino acid in the blood and the diverse birth defects and adult diseases associated with hyperhomocysteinemia. [less ▲]

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See detailSupport of Virasoro unitarizing measures
Airault, Hélène; Malliavin, Paul; Thalmaier, Anton UL

in Comptes Rendus. Mathématique (2002), 335(7), 621-626

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See detailSmectic filaments in colloidal suspensions of rods
Frenkel, Daan; Schilling, Tanja UL

in Physical Review. E ,Statistical, Nonlinear, and Soft Matter Physics (2002), 66(4),

In supersaturated isotropic mixtures of hard rods, smectic filaments have recently been observed. We propose a model for formation and growth of these filaments similar to the Hoffman-Lauritzen model for ... [more ▼]

In supersaturated isotropic mixtures of hard rods, smectic filaments have recently been observed. We propose a model for formation and growth of these filaments similar to the Hoffman-Lauritzen model for polymer crystallization. Filament thickness is determined by a compromise between maximizing the amount of smectic phase formed and minimizing the nucleation barrier for adding new segments to the growing filament. We compare our analytical results to kinetic Monte Carlo simulations. [less ▲]

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See detailPädagogische Qualität als erziehungswissenschaftliches Problem.
Honig, Michael-Sebastian UL

in Neue Praxis: Zeitschrift für Sozialarbeit, Sozialpädagogik und Sozialpolitik (2002), 32(3), 216-230

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See detailABCA1 regulatory variants influence coronary artery disease independent of effects on plasma lipid levels
Zwarts, K. Y.; Clee, S. M.; Zwinderman, A. H. et al

in Clinical Genetics (2002), 61(2), 115-125

The authors have previously shown that individuals heterozygous for ABCA1 mutations have decreased high density lipoprotein cholesterol, increased triglycerides and an increased frequency of coronary ... [more ▼]

The authors have previously shown that individuals heterozygous for ABCA1 mutations have decreased high density lipoprotein cholesterol, increased triglycerides and an increased frequency of coronary artery disease (CAD), and that single nucleotide polymorphisms (SNPs) in the coding region of the ABCA1 gene significantly impact plasma lipid levels and the severity of CAD in the general population. They have now identified several SNPs in non-coding regions of ABCA1 which may be important for the appropriate regulation of ABCA1 expression (i.e. in the promoter, intron 1 and the 5′ untranslated region), and have examined the phenotypic effects of these SNPs in the REGRESS population. Out of 12 SNPs, four were associated with a clinical outcome. A threefold increase in coronary events with an increased family history of CAD was evident for the G-191C variant. Similarly, the C69T SNP was associated with a twofold increase in events. In contrast, the C-17G was associated with a decrease in coronary events and the InsG319 was associated with less atherosclerosis. For all these SNPs, the changes in atherosclerosis and CAD occurred without detectable changes in plasma lipid levels. These data suggest that common variation in non-coding regions of ABCA1 may significantly alter the severity of atherosclerosis, without necessarily influencing plasma lipid levels. [less ▲]

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See detailDécision de la Cour de cassation, 2ème Civ., 30 janvier 2002
Cuniberti, Gilles UL

in Juris-Classeur périodique (2002)

Obligation d’information d’un tiers saisi concernant des comptes étrangers.

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See detailThe philosophy of educational leadership: Emerging themes and emerging perspectives.
Mirón,L.F.; Biesta, Gert UL

in Studies in Philosophy and Education (2002), 21(2), 101-102

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See detailMutation analysis and association studies of nuclear factor-kappaB1 in sporadic Parkinson's disease patients.
Wintermeyer, P.; Riess, O.; Schols, L. et al

in Journal of Neural Transmission (2002), 109(9), 1181-8

Biochemical and morphological studies revealed that oxidative stress and apoptosis play a role in neurodegeneration in Parkinson's disease (PD). Reactive oxygen species may be directly involved in ... [more ▼]

Biochemical and morphological studies revealed that oxidative stress and apoptosis play a role in neurodegeneration in Parkinson's disease (PD). Reactive oxygen species may be directly involved in apoptosis or via upregulation of toxic cytokines, i.e. tumor necrosis factor alpha (TNFalpha). We recently demonstrated that the TNFalpha pathway contributes to the pathogenesis of sporadic PD using a genetic approach. These signalling pathways converge to the transcription factor nuclear factor kappaB (NF-kappaB), which has been found activated in affected neurons in PD. We performed a detailed mutation analysis of the p50 subunit of NF-kappaB (NFKB1 gene) in 96 sporadic PD patients. Previously, positive association was demonstrated in this cohort to chromosome 4q21-23 containing the NFKB1 gene. We identified three base exchanges not affecting the amino acid sequence, which were found at similar frequencies in controls. Our study does not support a genetically definable role of NFKB1 in the pathogenesis of sporadic PD. [less ▲]

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See detailPrävention der Posttraumatischen Belastungsstörung bei Bankangestellten nach einem Überfall
Steffgen, Georges UL; De Boer, Claudia; Bollendorff, Claude

in Arbeitsmedizin, Sozialmedizin, Umweltmedizin (2002), 37

Aim of the study: Years after being victims of a bank robbery, bank clerks still suffer from severe symptoms of post-traumatic stress. As a result of this problem, a preventive intervention program me to ... [more ▼]

Aim of the study: Years after being victims of a bank robbery, bank clerks still suffer from severe symptoms of post-traumatic stress. As a result of this problem, a preventive intervention program me to reduce post-traumatic stress was established and evaluated for the Luxembourgish financial sector. Methods and collective: The study describes the measures carried out after a hold-up. Using non-parametric data evaluation, the effects of the intervention program me were examined for the treatment group (n= 43) and compared with a control group (n= 29). Results: The symptoms of post-traumatic stress were significantly reduced in the group which received crisis intervention and stress debriefing. Conclusions: These results are the first evidence of the effectiveness of the multi-component programme. [less ▲]

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See detailReview of R. Dirven et al. (eds) Language and Ideology
Weber, Jean-Jacques UL

in BELL. Belgian Journal of English Language and Literatures (2002), 11

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See detailCryptographie et lutte contre le terrorisme : éviter les fausses solutions sécuritaires
Warusfel, Bertrand; Leprévost, Franck UL

in Droit et Défense (2002)

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See detailReview of Priestley, Mark (Ed.), Disability and the Life Course: Global Perspectives, Cambridge: Cambridge University Press, 2001
Powell, Justin J W UL

in Kölner Zeitschrift für Soziologie und Sozialpsychologie (2002), 54(3), 397-398

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See detailA probabilistic approach to the Yang-Mills heat equation
Arnaudon, Marc; Bauer, Robert O.; Thalmaier, Anton UL

in Journal de Mathématiques Pures et Appliquées (2002), 81(2), 143-166

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See detailOrientational constraints of the gp130 intracellular juxtamembrane domain for signaling
Greiser, J. S.; Stross, C.; Heinrich, P. C. et al

in Journal of Biological Chemistry (2002), 277(30), 26959-65

The glycoprotein 130 (gp130) is the common signal transducing receptor chain of the interleukin-6 family of cytokines. Here we investigated the requirements for transfer of the information given by ligand ... [more ▼]

The glycoprotein 130 (gp130) is the common signal transducing receptor chain of the interleukin-6 family of cytokines. Here we investigated the requirements for transfer of the information given by ligand binding to the cytoplasmic domain of gp130. It is demonstrated that the box 1/2 region has to be located membrane-proximally in order to bind and activate Janus kinases. To test the possible requirement of an alpha-helical orientation, we inserted 1-4 alanine residues into this juxtamembrane intracellular region. The insertion of one alanine results in a strongly reduced activation of STAT1 and STAT3, whereas insertion of three alanine residues leads to a stronger STAT activation. These results suggest that gp130-mediated activation of STATs is sensitive to rotational changes around the receptor axis perpendicular to the membrane. Surprisingly, insertion of 1, 2, 3, or 4 alanine residues into this juxtamembrane region leads to successive impairment but not abolishment of Janus kinase and receptor phosphorylation, supporting the finding of sensitivity of Janus kinases toward changes in distance of box 1/2 from the plasma membrane. We suggest a new model concerning the gp130 activation mode in which the relative orientation of the cytoplasmic regions seems to be critical for further signal transduction. [less ▲]

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See detailLes devoirs d'information de l'investisseur sur les marchés spéculatifs aux Etats-Unis
Conac, Pierre-Henri UL

in Revue de Droit Bancaire et Financier (2002), (6), 354-359

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See detailImproving Research Productivity at a Pharmaceutical Company
Ramakrishnan, S.; Caruso, A.; Schneider, Reinhard UL

in LION bioscience AG White Paper (2002)

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See detailFamiliale Vererbung von Dominanzideologien in verschiedenen sozio-ökonomischen Kontexten
Hadjar, Andreas UL; Baier, Dirk

in Zeitschrift für Politische Psychologie (2002), 10

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See detailHuman centered processes and decision support systems
Barthélemy, J. P.; Bisdorff, Raymond UL; Coppin, G.

in European Journal of Operational Research (2002), 136(2), 233-252

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See detailHow general can Bildung be? Reflections on the future of a modern educational ideal.
Biesta, Gert UL

in Journal of Philosophy of Education (2002), 36(3), 377-390

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See detailA new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor.
Hortner, Michael; Nielsch, Ulrich; Mayr, Lorenz M. et al

in European Journal of Biochemistry (2002), 269(10), 2516-26

Erythropoietin (Epo) is a hematopoietic cytokine that is crucial for the differentiation and proliferation of erythroid progenitor cells. Epo acts on its target cells by inducing homodimerization of the ... [more ▼]

Erythropoietin (Epo) is a hematopoietic cytokine that is crucial for the differentiation and proliferation of erythroid progenitor cells. Epo acts on its target cells by inducing homodimerization of the erythropoietin receptor (EpoR), thereby triggering intracellular signaling cascades. The EpoR encompasses eight tyrosine motifs on its cytoplasmic tail that have been shown to recruit a number of regulatory proteins. Recently, the feedback inhibitor suppressor of cytokine signaling-3 (SOCS-3), also referred to as cytokine-inducible SH2-containing protein 3 (CIS-3), has been shown to act on Epo signaling by both binding to the EpoR and the EpoR-associated Janus kinase 2 (Jak2) [Sasaki, A., Yasukawa, H., Shouda, T., Kitamura, T., Dikic, I. & Yoshimura, A. (2000) J. Biol. Chem 275, 29338-29347]. In this study tyrosine 401 was identified as a binding site for SOCS-3 on the EpoR. Here we show that human SOCS-3 binds to pY401 with a Kd of 9.5 microm while another EpoR tyrosine motif, pY429pY431, can also interact with SOCS-3 but with a ninefold higher affinity than we found for the previously reported motif pY401. In addition, SOCS-3 binds the double phosphorylated motif pY429pY431 more potently than the respective singly phosphorylated tyrosines indicating a synergistic effect of these two tyrosine residues with respect to SOCS-3 binding. Surface plasmon resonance analysis, together with peptide precipitation assays and model structures of the SH2 domain of SOCS-3 complexed with EpoR peptides, provide evidence for pY429pY431 being a new high affinity binding site for SOCS-3 on the EpoR. [less ▲]

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See detailEvaluation of the precision of using absolute gravimeters to calibrate superconducting gravimeters
Francis, Olivier UL; van Dam, Tonie UL

in Metrologia (2002), 39(5), 485-488

We present an experiment in which four different FG5 absolute gravimeters (AG) were operated simultaneously alongside a superconducting relative gravimeter (SG). We demonstrate that 0.1 % precision can be ... [more ▼]

We present an experiment in which four different FG5 absolute gravimeters (AG) were operated simultaneously alongside a superconducting relative gravimeter (SG). We demonstrate that 0.1 % precision can be achieved on the calibration factor of the SG by comparison with AG measurements, independently of the FG5 instrument used for the calibration and of the offsets among the FG5 absolute values. This experiment demonstrates the robustness of using any FG5 absolute gravimeter to calibrate any SG. This result is of value to geoscientists analysing data from (a) globally distributed SGs which most probably have been calibrated using different instruments; or (b) any individual SG calibrated with different FG5 absolute gravimeters. [less ▲]

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See detailCity Logistics. Network Modelling and Intelligent Transport Systems
Hesse, Markus UL

in Journal of Transport Geography (2002), 10

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See detailEindrucksbildung aus Personbeschreibungen: Der Einfluss der syntaktischen Kohärenz auf die soziale Kognition
Wintermantel, Margret; Krolak-Schwerdt, Sabine UL

in Zeitschrift für Sozialpsychologie (2002), 33

This paper concerns the comprehension of person descriptions. In two experiments we investigated the influence of syntactical coherence and ease of categorization of the information on person memory and ... [more ▼]

This paper concerns the comprehension of person descriptions. In two experiments we investigated the influence of syntactical coherence and ease of categorization of the information on person memory and judgments. Ss listened to person descriptions which contained phrases concerning single person attributes. These phrases were either highly connected by prepositions or totally unconnected. In addition, the texts differed in their degree of categorizability, one activating a social stereotype and the other containing individual attributes. In Experiment I the Ss had to reproduce the text and in Experiment II the task was to summarize the information. In Experiment I the reproduction rates increased significantly with the connectedness in the case of non-stereotypical information. In Experiment II, we found more complex inference patterns under the same condition. The results are discussed within the associative network approach to person memory. It is argued that this approach has to be further differentiated with regard to particular logical relations between person attributes. [less ▲]

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See detailHegel, Sellars und der Mythos des Gegebenen
Heidemann, Dietmar UL

in Hegel-Jahrbuch (2002)

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See detailProgressive loss of PAX9 expression correlates with increasing malignancy of dysplastic and cancerous epithelium of the human oesophagus.
Gerber, Josef-Karl; Richter, Thomas; Kremmer, Elisabeth et al

in Journal of Pathology (2002), 197(3), 293-7

Pax genes encode a family of transcription factors that play key roles in embryonic development. Whereas the functions of Pax genes in the adult organism are largely unknown, upregulated Pax gene ... [more ▼]

Pax genes encode a family of transcription factors that play key roles in embryonic development. Whereas the functions of Pax genes in the adult organism are largely unknown, upregulated Pax gene expression has been implicated in tumourigenesis. In this study, PAX9-specific monoclonal antibodies have been generated and it has been shown that PAX9 protein is expressed in the normal epithelium of the adult human oesophagus. PAX9 expression was either lost or significantly reduced in the majority of invasive carcinomas and epithelial dysplasias, the latter representing precancerous lesions. Notably, the percentage of PAX9-positive cells within the epithelium decreased with increasing malignancy of the epithelial lesion. These results identify PAX9 as a sensitive marker for deregulated differentiation of oesophageal keratinocytes and indicate a role for PAX9 in the normal differentiation process of internal stratified squamous epithelia. These data suggest that upregulated PAX9 expression is not required for the formation of the majority of squamous cell carcinomas of the human oesophagus. [less ▲]

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See detailBijan Adl-Amini: Pestalozzi. Eine Einladung zur Erziehung
Tröhler, Daniel UL

in Zeitschrift für Pädagogik (2002), 48

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See detailA lower bound for the volume-averaged mean-square magnetostatic stray field
Michels, Andreas UL; Weissmüller, J.; Birringer, R.

in European Physical Journal B -- Condensed Matter (2002), 29

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See detailEquivariant symbol calculus for differential operators acting on forms
Boniver, Fabien; Hansoul, Sarah; Mathonet, Pierre UL et al

in Letters in Mathematical Physics (2002), 62(3), 219-232

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See detailEffect of additional temporary glycoprotein IIb/IIIa receptor inhibition on troponin release in elective percutaneous coronary interventions after pretreatment with aspirin and clopidogrel (TOPSTAR trial).
Bonz, Andreas W.; Lengenfelder, Bjorn; Strotmann, Jorg et al

in Journal of the American College of Cardiology (2002), 40(4), 662-8

OBJECTIVES: The Troponin in Planned PTCA/Stent Implantation With or Without Administration of the Glycoprotein IIb/IIIa Receptor Antagonist Tirofiban (TOPSTAR) trial investigated: 1) the amount of ... [more ▼]

OBJECTIVES: The Troponin in Planned PTCA/Stent Implantation With or Without Administration of the Glycoprotein IIb/IIIa Receptor Antagonist Tirofiban (TOPSTAR) trial investigated: 1) the amount of troponin T (TnT) release after nonacute, elective percutaneous coronary intervention (PCI) in patients pretreated with aspirin and clopidogrel; and 2) the effect of additional glycoprotein (GP) IIb/IIIa receptor inhibiton on postinterventional TnT release. BACKGROUND: No data are available yet as to whether additional administration of a GP IIb/IIIa receptor antagonist might be beneficial in patients undergoing elective PCI already pretreated with aspirin and clopidogrel. METHODS: After bolus application of the study medication (tirofiban [T] or placebo [P]), PCI was performed followed by an 18-h continuous infusion of T/P. Primary end point of the study was incidence and amount of TnT release after elective PCI after 24 h. RESULTS: A total of 12 h after PCI troponin release was detected in 63% of the patients receiving P and in 40% of the patients receiving T (p < 0.05), after 24 h in 69% (P) and 48% (T) (p < 0.05) and after 48 h in 74% (P) versus 58% (T) (p < 0.08) of the patients. No differences were observed regarding major bleeding, intracranial bleeding or nonhemorrhagic strokes. After nine months a reduction of combined death/myocardial infarction/target vessel revascularization could be observed in the tirofiban group ([T] 2.3% vs. [P] 13.04%, p < 0.05). CONCLUSIONS: Troponin T release occurs after successful intervention in 74% of the patients undergoing elective PCI after 48 h even after pretreatment with aspirin and clopidogrel. The GP IIb/IIIa receptor antagonist tirofiban is able to decrease the incidence of troponin release significantly in this patient population. [less ▲]

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See detailDie Legitimation des Aktionärs
Zetzsche, Dirk Andreas UL; Noack, U.

in Aktiengesellschaft (Die) (2002)

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See detailImplementation of the Statute of the International Criminal Court, Hungarian National Report
Ligeti, Katalin UL; Weiner, Imre A.

in Acta Juridica Hungarica (2002)

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See detailThe Introduction of a Design Heuristics Extraction Method
Matthews, P. C.; Blessing, Lucienne UL; Wallace, K. M.

in Advanced Engineering Informatics (2002), 16

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See detailAlGaN/GaN HEMTs on (111) Silicon Substrates
Javorka, P.; Alam, A.; Wolter, M. et al

in IEEE Electron Device Letters (2002), 23(2002), 4-6

AlGaN/GaN HEMTs on silicon substrates have been fabricated and their static and small-signal RF characteristics investigated. The AlGaN/GaN material structures were grown on (111) p-Si by LP-MOVPE ... [more ▼]

AlGaN/GaN HEMTs on silicon substrates have been fabricated and their static and small-signal RF characteristics investigated. The AlGaN/GaN material structures were grown on (111) p-Si by LP-MOVPE. Devices exhibit a saturation current of 0.91 A/mm, a good pinchoff and a peak extrinsic transconductance of 122 mS/mm. A unity current gain frequency of 12.5 GHz and fmax/fT=0.83 were obtained. The highest saturation current reported so far, static output characteristics of up to 20 V and breakdown voltage at pinchoff higher than 40 V demonstrate that the devices are capable of handling 16 W/mm static heat dissipation. [less ▲]

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See detailOestrogen action on the myocardium in vivo: specific and permissive for angiotensin-converting enzyme inhibition.
Pelzer, Theo; de Jager, Tertia; Muck, Jenny et al

in Journal of hypertension (2002), 20(5), 1001-6

OBJECTIVES: In contrast to the vasculature, it remains unclear whether oestrogens also directly affect the myocardium. In this study, we addressed basic questions regarding oestrogen effects on the ... [more ▼]

OBJECTIVES: In contrast to the vasculature, it remains unclear whether oestrogens also directly affect the myocardium. In this study, we addressed basic questions regarding oestrogen effects on the myocardium, including specificity, pathophysiological relevance and potential clinical implications, with a special focus on interactions between oestrogen and angiotensin-converting enzyme (ACE) inhibitors in an established in-vivo model of cardiac hypertrophy. METHODS AND RESULTS: Female spontaneously hypertensive rats (SHR) were ovarectomized (OVX) or sham-operated and treated with 17beta-oestradiol (2 microg/kg per day subcutaneously), the oestrogen receptor antagonist ZM-182780 (250 microg/kg per day subcutaneously) and the ACE-inhibitor moexipril (10 mg/kg per day orally) alone or in combination for 3 months. Hormone replacement restored physiological oestradiol serum levels and prevented uterus atrophy. Whereas moexipril alone was ineffective in OVX rats, substitution of oestradiol restored the beneficial effect of moexipril on systolic blood pressure (-30 +/- 5 mmHg) and relative heart weight (-11 +/- 3%) in OVX rats. Oestradiol upregulated alpha-myosin heavy chain (MHC) mRNA (+37 +/- 7%) and protein expression (+43 +/- 6%) in spite of increased blood pressure in OVX rats. Simultaneous treatment with oestradiol plus moexipril most effectively shifted the ratio of alpha-/beta-MHC mRNA and protein expression towards alpha-MHC in OVX animals. Oestradiol (10 nmol/l) also upregulated alpha-MHC mRNA and protein in cultured cardiac myocytes. The oestrogen receptor antagonist ZM-182780 significantly inhibited the observed oestrogen effects. CONCLUSIONS: Oestrogen replacement is permissive for the beneficial effects of ACE-inhibition in female SHR rats. Oestrogen effects on the myocardium in vivo are specific (i.e. oestrogen receptor mediated) because they are inhibited by a pure oestrogen receptor antagonist and occur at physiological hormone levels. [less ▲]

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See detailReview of P. Verdonk. Stylistics
Weber, Jean-Jacques UL

in Style (2002), 36

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See detailPoésie d’amour française et musique pluriculturelle. La mise en musique du poème de Louis Aragon Gazel au fond de la nuit par le groupe Gnawa Diffusion
Hu, Adelheid UL; Dannhorn, Susanne; Luquin-Elhilali, Pauline

in Französisch Heute (2002), 33(1), 55-63

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See detailThe matrix metalloproteinase 9 (mmp-9) hemopexin domain is a novel gelatin binding domain and acts as an antagonist
Roeb, E.; Schleinkofer, K.; Kernebeck, T. et al

in Journal of Biological Chemistry (2002), 277(52), 50326-32

Matrix metalloproteinases (MMPs) are involved in the remodeling processes of the extracellular matrix and the basement membrane. Most MMPs are composed of a regulatory, a catalytic, and a hemopexin ... [more ▼]

Matrix metalloproteinases (MMPs) are involved in the remodeling processes of the extracellular matrix and the basement membrane. Most MMPs are composed of a regulatory, a catalytic, and a hemopexin subunit. In many tumors the expression of MMP-9 correlates with local tumor growth, invasion, and metastasis. To analyze the role of the hemopexin domain in these processes, the MMP-9 hemopexin domain (MMP-9-PEX) was expressed as a glutathione S-transferase fusion protein in Escherichia coli. After proteolytic cleavage, the isolated PEX domain was purified by size exclusion chromatography. In a zymography assay, MMP-9-PEX was able to inhibit MMP-9 activity. The association and dissociation rates for the interaction of MMP-9-PEX with gelatin were determined by plasmon resonance. From the measured rate constants, the dissociation constant was calculated to be K(d) = 2,4 x 10(-8) m, demonstrating a high affinity between MMP-9-PEX and gelatin. In Boyden chamber experiments the recombinant MMP-9-PEX was able to inhibit the invasion of melanoma cells secreting high amounts of MMP-9 in a dose-dependent manner. These data demonstrate for the first time that the hemopexin domain of MMP-9 has a high affinity binding site for gelatin, and the particular recombinant domain is able to block MMP-9 activity and tumor cell invasion. Because MMP-9 plays an important role in metastasis, this antagonistic effect may be utilized to design MMP inhibition-based cancer therapy. [less ▲]

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See detailArbeit zwischen Berufsarbeit und Demokratie
Tröhler, Daniel UL

in Unimagazin : die Zeitschrift der Universität Zürich (2002), 3

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See detailZum Problem der Konversion in historisch orientierten Wortbildungsanalysen
Sieburg, Heinz UL

in Germanistik. Publications du Centre Universitaire du Luxembourg. Lettres Allemandes (2002)

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See detailNote sous C. cass. Ch. Mixte, 12 avril 2002, société d'exploitation cinématographique Rex et autres c. société Cinémas Rex
Conac, Pierre-Henri UL

in Semaine Juridique. Édition Générale (2002), (44), 1961-1964

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See detailVor Outlook sind wir alle gleich - Egalisierungs- und Hierarchisierungstendenzen im Zuge der E-Mail-Nutzung.
Lenz, Thomas UL; Jäckel, Michael; Zillien, Nicole

in Kommunikation@gesellschaft (2002), 3

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See detailL’industrie électrique dans l’économie européenne, 1860-1914
Leboutte, René UL

in Bulletin Scientifique de l'Association des Ingénieurs Electriciens sortis de l'Institut Electrotechnique Montefiore (2002), 115

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See detailParkinson's disease: one biochemical pathway to fit all genes?
Krüger, Rejko UL; Eberhardt, Olaf; Riess, Olaf et al

in Trends in molecular medicine (2002), 8(5), 236-40

Although originally discounted, hereditary factors have emerged as the focus of research in Parkinson's disease (PD). Genetic studies have identified mutations in alpha-synuclein and ubiquitin C-terminal ... [more ▼]

Although originally discounted, hereditary factors have emerged as the focus of research in Parkinson's disease (PD). Genetic studies have identified mutations in alpha-synuclein and ubiquitin C-terminal hydrolase as rare causes of autosomal dominant PD and mutations in parkin as a cause of autosomal recessive PD. Functional characterization of the identified disease genes implicates the ubiquitin-mediated protein degradation pathway in these hereditary forms of PD and also in the more common sporadic forms of PD. Subsequent identification of further loci in familial PD and diverse genetic factors modulating the risk for sporadic PD point to substantial genetic heterogeneity in the disease. Thus, new candidate genes are expected to encode proteins either involved in ubiquitin-mediated protein degradation or sequestrated in intracytoplasmic protein aggregations. Future identification of disease genes is required to confirm this hypothesis, thereby unifying the clinical and genetic heterogeneity of PD, including the common sporadic form of the disease, by one biochemical pathway. [less ▲]

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See detailAnnealing of Schottky contacts deposited on dry etched AlGaN/GaN,
Kuzmík, J.; Javorka, P.; Marso, Michel UL et al

in Semiconductor Science and Technology (2002), 17((2002).), 76-78

The influence of annealing on properties of Pt Schottky contacts deposited on the electron cyclotron resonance plasma etched surface of an AlGaN/GaN heterostructure has been investigated. It is found that ... [more ▼]

The influence of annealing on properties of Pt Schottky contacts deposited on the electron cyclotron resonance plasma etched surface of an AlGaN/GaN heterostructure has been investigated. It is found that rapid thermal annealing (450 ◦C and 40 s in nitrogen gas), performed after metal deposition, allows for the preparation of Schottky contacts with similar or better properties than those obtained on a non-etched surface. This procedure is suitable for the realization of recessed high-quality Schottky contacts of AlGaN/GaN HEMTs. [less ▲]

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See detailSuppressor of cytokine signaling-3 is recruited to the activated granulocyte-colony stimulating factor receptor and modulates its signal transduction.
Hortner, Michael; Nielsch, Ulrich; Mayr, Lorenz M. et al

in Journal of immunology (2002), 169(3), 1219-27

G-CSF is a polypeptide growth factor used in treatment following chemotherapy. G-CSF regulates granulopoiesis and acts on its target cells by inducing homodimerization of the G-CSFR, thereby activating ... [more ▼]

G-CSF is a polypeptide growth factor used in treatment following chemotherapy. G-CSF regulates granulopoiesis and acts on its target cells by inducing homodimerization of the G-CSFR, thereby activating intracellular signaling cascades. The G-CSFR encompasses four tyrosine motifs on its cytoplasmic tail that have been shown to recruit a number of regulatory proteins. Suppressor of cytokine signaling 3 (SOCS-3), also referred to as cytokine-inducible Src homolgy 2-containing protein 3, is a member of a recently discovered family of feedback inhibitors that have been shown to inhibit the Janus kinase/STAT pathway. In this study, we demonstrate that human SOCS-3 is rapidly induced by G-CSF in polymorphonuclear neutrophils as well as in the myeloid precursor cell line U937 and that SOCS-3 negatively regulates G-CSFR-mediated STAT activation. Most importantly, we show that SOCS-3 is recruited to the G-CSFR in a phosphorylation-dependent manner and we identify phosphotyrosine (pY)729 as the major recruitment site for SOCS-3. Furthermore, we demonstrate that SOCS-3 directly binds to this pY motif. Surface plasmon resonance analysis reveals a dissociation constant (K(D)) for this interaction of around 2.8 microM. These findings strongly suggest that the recruitment of SOCS-3 to pY729 is important for the modulation of G-CSFR-mediated signal transduction by SOCS-3. [less ▲]

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