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See detailWerteerziehung und pluralistische Gesellschaft
Tröhler, Daniel UL

in Aktuell (1996), (4), 7-10

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See detailGeneCrunch: Experiences on the SGI POWER CHALLENGEarray with Bioinformatics applications
Schneider, Reinhard UL; Casari, G.; Daruvar, A. et al

in Supercomputer 96 : Anwendungen, Architekturen, Trends (1996)

Analyzing genomic data is a computationally intensive and complicated process in which scientists must typically choose among multiple databases and analysis methods and make expert judgements inspecting ... [more ▼]

Analyzing genomic data is a computationally intensive and complicated process in which scientists must typically choose among multiple databases and analysis methods and make expert judgements inspecting multiple results. GeneQuiz, an automated software system for large scale genome analysis developed at the EMBL/EBI, tackles this problem by using an automated, rigorous, rule-based system to select among the results of sequence analysis and database searches, builds informative annotation and aims at predicting the function of new genes. In a demonstration project more than 6000 proteins from the Baker’s yeast, for which the complete genomic sequence was completed in 1996, were analyzed on a Silicon Graphics POWERCHALLENGEarray with 64 processors (R8000 @90 MHz) so that the analysis could be completed in 3 days. The results of the analysis were published on two web servers as they were computed. [less ▲]

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See detailInterkultureller Fremdsprachenunterricht und die Heterogenität von Kulturen
Hu, Adelheid UL

in Zeitschrift für Interkulturellen Fremdsprachenunterricht (1996), 1(3), 16

Detailed reference viewed: 182 (1 UL)
See detailMessung des Selbstwertgefühls: Befunde zu Reliabilität, Validität und Stabilität der Rosenberg-Skala.
Ferring, Dieter UL; Filipp, Sigrun-Heide

in Focus Diagnostica (1996), 42(3)

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See detailThe dirac oscillator of arbitrary spin
del Sol Mesa, Antonio UL

in Journal of Physics: A Mathematical and General (1996)

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See detailBespreking van Max Velthuis, Kikker is verliefd.
Biesta, Gert UL

in Comenius (1996), 16

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See detailA Restriction Theorem for Ideals in the Schwartz Algebra of a Nilpotent Lie Group
Ludwig, Jean; Molitor-Braun, Carine UL

in Archiv der Mathematik [=ADM] (1996), 67(3), 199-210

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See detailDivergent sequence motifs correlated with the substrate specificity of (methyl)malonyl-CoA:acyl carrier protein transacylase domains in modular polyketide synthases.
Haydock, S. F.; Aparicio, J. F.; König, Ariane UL et al

in FEBS Letters (1995), 374(2), 246-248

The amino acid sequences of a large number of polyketide synthase domains that catalyse the transacylation of either methylmalonyl-CoA or malonyl-CoA onto acyl carrier protein (ACP) have been compared ... [more ▼]

The amino acid sequences of a large number of polyketide synthase domains that catalyse the transacylation of either methylmalonyl-CoA or malonyl-CoA onto acyl carrier protein (ACP) have been compared. Regions were identified in which the acyltransferase sequences diverged according to whether they were specific for malonyl-CoA or methylmalonyl-CoA. These differences are sufficiently clear to allow unambiguous assignment of newly-sequenced acyltransferase domains in modular polyketide synthases. Comparison with the recently-determined structure of the malonyltransferase from Escherichia coli fatty acid synthase showed that the divergent region thus identified lies near the acyltransferase active site, though not close enough to make direct contact with bound substrate. [less ▲]

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See detailDie Pädagogik des Fin de Siècle - een impressie
Biesta, Gert UL

in Nieuwsbrief BNVGOO (1995), 4

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See detailThe biosynthetic cluster for the polyketide immunosuppressant rapamycin
Schwecke, T.; Aparicio, J. F.; Molnár, I. et al

in Proceedings of the National Academy of Sciences of the United States of America (1995), 92(17), 7839-7843

The macrocyclic polyketides rapamycin and FK506 are potent immunosuppressants that prevent T-cell proliferation through specific binding to intracellular protein receptors (immunophilins). The cloning and ... [more ▼]

The macrocyclic polyketides rapamycin and FK506 are potent immunosuppressants that prevent T-cell proliferation through specific binding to intracellular protein receptors (immunophilins). The cloning and specific alteration of the biosynthetic genes for these polyketides might allow the biosynthesis of clinically valuable analogues. We report here that three clustered polyketide synthase genes responsible for rapamycin biosynthesis in Streptomyces hygroscopicus together encode 14 homologous sets of enzyme activities (modules), each catalyzing a specific round of chain elongation. An adjacent gene encodes a pipecolate-incorporating enzyme, which completes the macrocycle. The total of 70 constituent active sites makes this the most complex multienzyme system identified so far. The DNA region sequenced (107.3 kbp) contains 24 additional open reading frames, some of which code for proteins governing other key steps in rapamycin biosynthesis. [less ▲]

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See detailIdentiteit, cultuur en opvoeding. Impressies van het vierde congres van het International Network of Philosophers of Education
Biesta, Gert UL

in Pedagogisch Tijdschrift: Forum voor Opvoedkunde (1995), 20(1), 57-64

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See detailCharacterization of the ordered weighted averaging operators
Fodor, Janos; Marichal, Jean-Luc UL; Roubens, Marc

in IEEE Transactions on Fuzzy Systems (1995), 3(2), 236-240

This paper deals with the characterization of two classes of monotonic and neutral (MN) aggregation operators. The first class corresponds to (MN) aggregators which are stable for the same positive linear ... [more ▼]

This paper deals with the characterization of two classes of monotonic and neutral (MN) aggregation operators. The first class corresponds to (MN) aggregators which are stable for the same positive linear transformations and presents the ordered linkage property. The second class deals with (MN)-idempotent aggregators which are stable for positive linear transformations with the same unit, independent zeroes and ordered values. These two classes correspond to the weighted ordered averaging operator (OWA) introduced by Yager in 1988. It is also shown that the OWA aggregator can be expressed as a Choquet integral. [less ▲]

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See detailVon Mäusen und Menschen In: “Genetische Determinierung: Schicksal aus den Genen?”
Balling, Rudi UL

in GSF-Mensch und Umwelt (1995), (10), 17-23

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See detailTargeting of Listeria monocytogenes ActA protein to the plasma membrane as a tool to dissect both actin-based cell morphogenesis and ActA function.
Friederich, Evelyne UL; Gouin, E.; Hellio, R. et al

in The EMBO journal (1995), 14(12), 2731-44

Actin assembly on the surface of Listeria monocytogenes in the cytoplasm of infected cells provides a model to study actin-based motility and changes in cell shape. We have shown previously that the ActA ... [more ▼]

Actin assembly on the surface of Listeria monocytogenes in the cytoplasm of infected cells provides a model to study actin-based motility and changes in cell shape. We have shown previously that the ActA protein, exposed on the bacterial surface, is required for polarized nucleation of actin filaments. To investigate whether plasma membrane-associated ActA can control the organization of microfilaments and cell shape, variants of ActA, in which the bacterial membrane signal had been replaced by a plasma membrane anchor sequence, were produced in mammalian cells. While both cytoplasmic and membrane-bound forms of ActA increased the F-actin content, only membrane-associated ActA caused the formation of plasma membrane extensions. This finding suggests that ActA acts as an actin filament nucleator and shows that permanent association with the inner face of the plasma membrane is required for changes in cell shape. Based on the observation that the amino-terminal segment of ActA and the remaining portion which includes the proline-rich repeats cause distinct phenotypic modifications in transfected cells, we propose a model in which two functional domains of ActA cooperate in the nucleation and dynamic turnover of actin filaments. The present approach is a new model system to dissect the mechanism of action of ActA and to further investigate interactions of the plasma membrane and the actin cytoskeleton during dynamic changes of cell shape. [less ▲]

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See detailOn the institutional determinants of economic development. Lessons from a stochastic neoclassical growth model
Klump, Rainer UL

in Jahrbuch für Wirtschaftswissenschaften / Review of Economics (1995)

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See detailNovel HEMT layout: The RoundHEMT
Marso, Michel UL; Schimpf, K.; Fox, A. et al

in Electronics Letters (1995), 31(1995), 589-591

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See detailErstspracherwerb als Thema des akademischen Unterrichts
Sieburg, Heinz UL

in Germanistik. Publications du Centre Universitaire du Luxembourg. Lettres Allemandes (1995)

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See detailPestalozzi für den Schulgebrauch
Tröhler, Daniel UL

in Schweizerische Lehrerinnen- und Lehrer-Zeitung (1995), 140(23-24), 15-15

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See detailCHALLENGING TIMES FOR BIOINFORMATICS
CASARI, G.; ANDRADE, M. A.; BORK, P. et al

in Nature (1995), 376(6542), 647-648

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See detailKleist speichern. Zur Verzeichnung des handschriftlichen Nachlasses von Georg Minde-Pouet
Amann, Wilhelm UL; Wangermann, Tobias

in Brandenburger Kleist-Blätter (1995), 8

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See detailDie Kleist-Sammlung in der Amerika-Gedenkbibliothek, Berlin
Amann, Wilhelm UL

in Beiträge zur Kleist-Forschung (1995), 9

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See detailChromosomal localization of the murine cadherin-11.
Hoffman, I.; Balling, Rudi UL

in Mammalian Genome (1995), 6(4), 304

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See detailPsychologische Trainigs für die Praxis - Darstellung zweier Verfahren
Steffgen, Georges UL

in Psychologie und Sport -Schorndorf- (1995), 2(3), 1-5

Detailed reference viewed: 60 (1 UL)
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See detailAn Extended Quantum Model for Porous Silicon Formation
Frohnhoff, St; Marso, Michel UL; Berger, M. G. et al

in Journal of the Electrochemical Society (1995), 142(1995), 615-620

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See detailLe français et les langues mélanésiennes – des langues en contact
Ehrhart, Sabine UL

in Etudes Françaises (1995), (1), 79-85

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See detailThe role of APO-1-mediated apoptosis in the immune system
Krammer, P. H.; Dhein, J.; Walczak, H. et al

in Immunological Reviews (1995), 142

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See detailValidation of ocean tide models by comparison to gravity loading measurements
Francis, Olivier UL

in Marées Terrestres Bulletin d'Informations (1995), 122

Detailed reference viewed: 60 (3 UL)
See detailDas erste Spital in Luxemburg. Eine unerforschte Quelle zum Wirken Walrams von Monschau-Limburg und zur Geschichte der Stadt Luxemburg
Margue, Michel UL; Pauly, Michel UL

in Hemecht : Zeitschrift für Luxemburger Geschichte = Revue d'Histoire Luxembourgeoise (1995), 47(1), 15-42

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See detailKritische onderwijssociologie - vijftien jaar na dato (besprekingsartikel).
Biesta, Gert UL

in Pedagogisch Tijdschrift: Forum voor Opvoedkunde (1995), 20

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See detailJacobiennes de certaines courbes de genre 2 : torsion et simplicité
Leprévost, Franck UL

in Journal de Théorie des Nombres de Bordeaux (1995), 7

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See detailA simple method for a specific retrograde labelling of dorsal root and sympathetic ganglion cells innervating the knee joint of the cat.
Hanesch, Ulrike UL; Heppelmann, Bernd

in Journal of Neuroscience Methods (1995), 63

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See detailAssignment of the paired box gene Pax1 to rat chromosome 3.
Otsen, M.; Balling, Rudi UL; Den Bieman, M. et al

in Mammalian Genome (1995), 6(9), 666-7

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See detailSteigern psychische Belastungen das Eßbedürfnis? Eine experimentelle Studie an Bulimikerinnen
Tuschen-Caffier, Brunna; Vögele, Claus UL; Kuhnhardt, Karin et al

in Zeitschrift für Klinische Psychologie, Psychopathologie und Psychotherapie (1995), 24

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See detailIndustrial linear optimization problems solved by constraint logic programming
Bisdorff, Raymond UL; Laurent, S.

in European Journal of Operational Research (1995), 84(1), 82-95

In this article we illustrate that Constraint Logic Programming (CLP) systems allow easy expression and solutions of constrained decision problems. CLP solutions for two industrial linear optimization ... [more ▼]

In this article we illustrate that Constraint Logic Programming (CLP) systems allow easy expression and solutions of constrained decision problems. CLP solutions for two industrial linear optimization problems are discussed: - a mixed linear multiple criteria selection problem implemented in the linear rational Prolog III solver, and - a linear integer multiple criteria location problem, particularly adapted to the CHIP solver. [less ▲]

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See detailInP/InGaAs Photodetector Based on a High Electron Mobility Transistor Layer Structure: Its Response at 1.3 µm wavelength
Horstmann, M.; Marso, Michel UL; Fox, A. et al

in Applied Physics Letters (1995), 67(1995), 106-108

We report on the investigation of the room-temperature optoelectronic behavior of a metal–semiconductor–metal two-dimensional electron gas photodiode based on the two-dimensional electron gas of a high ... [more ▼]

We report on the investigation of the room-temperature optoelectronic behavior of a metal–semiconductor–metal two-dimensional electron gas photodiode based on the two-dimensional electron gas of a high electron mobility transistor structure. The photodetector is fabricated in the InP/InGaAs material system, without use of Al-containing layers. Optoelectronic measurements on a device with a finger spacing of 3 mm show a full width at half-maximum (FWHM) of the pulse response of <60 ps, which is the resolution limit of our measurement equipment. Low-temperature measurements at 40 K with electro-optical sampling at a wavelength of 890 nm show a FWHM of 1 ps. [less ▲]

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See detail«Een Eco-grafie van de cultroman»
Roelens, Nathalie UL

in ALW-Cahier (1995)

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See detailUrban Space and Logistics. On the road to Sustainability?
Hesse, Markus UL

in World Transport Policy & Practice (1995), 1(1), 39-45

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See detailRight-wing extremism, racism or youth violence? Explaining violence against foreigners in Germany
Willems, Helmut UL

in New Community (1995), 21(4), 501-523

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See detailStructure of the human APO-1 gene
Behrmann, Iris UL; Walczak, H.; Krammer, P. H.

in European Journal of Immunology (1995), 24(12), 3057-62

APO-1/Fas (CD95) is a type 1 transmembrane protein that belongs to the tumor necrosis factor/nerve growth factor receptor family characterized by cysteine-rich extracellular domains. Cross-linking of APO ... [more ▼]

APO-1/Fas (CD95) is a type 1 transmembrane protein that belongs to the tumor necrosis factor/nerve growth factor receptor family characterized by cysteine-rich extracellular domains. Cross-linking of APO-1 mediates apoptosis in a variety of cells. In the present study we report the isolation and characterization of the human APO-1 gene spanning approximately 25 kb of human chromosome 10. The gene consists of nine exons (25 bp to > 1.44 kb) separated by eight introns (152 bp to approximately 12 kb). The boundaries of exon 2 to 5 encoding the extracellular region do not match the boundaries of the three APO-1 protein subdomains. Exon structure and functional protein domains correspond for exon 6 encoding the transmembrane region and for exon 9 encoding the "death domain". By a polymerase chain reaction-based approach we localized major transcriptional start sites in human spleen cells 77 and 73 nucleotides upstream of the translation initiation codon of the human APO-1 gene. Minor initiation sites were found at positions -128, -111, -91, and -74. The 5' flanking sequence of the human APO-1 gene is GC rich, contains a high number of CpG dinucleotides and lacks a consensus TATA box. Consensus binding sites for the transcription factors Sp1, AP-1, AP-2, GAF, NF-kappa B, and NF-AT were found. The elucidation of the human APO-1 gene structure will facilitate the study of its involvement in various diseases such as in autoimmunity. [less ▲]

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See detailThe Imagination of a Radical Democracy. Een interview met Henry Giroux.
Miedema, S.; Biesta, Gert UL

in Comenius (1995), 15(2), 194-205

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See detailUne communauté sur le déclin? Les marchands hollandais à Bordeaux, 1650 - 1715
Voss, Peter UL

in Bulletin du Centre d'Histoire des Espaces Atlantiques (1995), 7

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See detailProvisional Utopias in a Post-Colonial World. Een interview met Peter McLaren.
Biesta, Gert UL; Miedema, S.

in Comenius (1995), 15(3), 335-347

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See detailAnalysis of data from the 1994 international comparison of absolute gravimeters with a single computational protocol
Sasagawa, G.; Klopping, F.; van Dam, Tonie UL

in Metrologia (1995), 32

Data from the 1994 International Comparison of Absolute Gravimeters were processed with the National Oceanic and Atmospheric Administration (NOAA) Geosciences Lab protocols and processing algorithms. The ... [more ▼]

Data from the 1994 International Comparison of Absolute Gravimeters were processed with the National Oceanic and Atmospheric Administration (NOAA) Geosciences Lab protocols and processing algorithms. The rootmean-square discrepancy between results obtained from individual groups and the NOAA processing is 2,3 μGal; the average discrepancy is 1,5 μGal. The sources of the discrepancies are probably (i) differences in the vertical gradients used for datum level transfers, (ii) inconsistencies between processing algorithms, and (iii) differences in data editing criteria. [less ▲]

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See detailFast and sensitive search of information databases for biological relationships
Schneider, Reinhard UL; Casari, G.; Sander, C.

in Statustagung des BMBF, HPSC 95, Stand und Perspektiven des Parallelen Höchstleistungsrechnens und seiner Anwendungen (1995)

Sequence comparison has become an essential and standard tool in the analysis of genomic data. Genome projects will decipher much of the genetic information in many organisms, including humans. As a ... [more ▼]

Sequence comparison has become an essential and standard tool in the analysis of genomic data. Genome projects will decipher much of the genetic information in many organisms, including humans. As a result, the computational cost of databank searches will increase dramatically. In addition, the search for biologically meaningful homology between a newly determined sequence and sequences already stored in the various databanks becomes increasingly important as most of the new data will be in raw, not understood form. The detection of sufficient similarity between a newly determined sequence to a protein of know function or even known 3D-structure in a databank allows one to transfer most of the knowledge from one sequence to the other. The result can be enormous savings in genetic and biochemical laboratory efforts. [less ▲]

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See detailEin runder Tisch für den Wirtschaftsverkehr. Prozessuale Planungs- und Kommunikationsformen
Hesse, Markus UL

in DISP Dokumente und Informationen zur Schweizerischen Orts-, Regional- und Landesplanung (1995), (121), 19-24

Erfahrungsbericht vom Einsatz prozessualer bzw. kommunikativer Planungsformen in einem tendenziell nicht-kommunikativen Milieu.

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See detailPossible Involvement of Gaba-B receptors in the sedative effects of nicotine in mice
Mancuso, Giovanna UL; Tirelli, Ezio

in Journal of Psychopharmacology (1995), 9(3), 51

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See detailInteraction between undulated and Patch leads to an extreme form of spina bifida in double-mutant mice.
Helwig, U.; Imai, K.; Schmahl, W. et al

in Nature Genetics (1995), 11(1), 60-3

The aetiology of spina bifida involves genetic and environmental factors, which may be why major genes contributing to pathogenesis have not been identified. Here we report that undulated-Patch double ... [more ▼]

The aetiology of spina bifida involves genetic and environmental factors, which may be why major genes contributing to pathogenesis have not been identified. Here we report that undulated-Patch double-mutant mice have a phenotype reminiscent of an extreme form of spina bifida occulta in humans. This unexpected phenotype in double-mutant but not single-mutant mice shows that novel congenital anomalies such as spina bifida can result from interaction between products of independently segregating loci. This example of digenic inheritance may explain the often sporadic nature of spina bifida in humans. [less ▲]

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See detailSomatostatin-like immunoreactivity in primary afferents of the medial articular nerve and colocalization with substance P in the cat
Hanesch, Ulrike UL; Heppelmann, Bernd; Schmidt, Robert

in Journal of Comparative Neurology (1995), 354

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See detailConformational behaviour of a synthetic peptide of the C-terminus of villin that interacts with actin: an NMR, CD and stimulated annealing study.
Simenel, C.; Rose, T.; Goethals, M. et al

in International journal of peptide and protein research (1995), 45(6), 574-86

The solution structure of a synthetic 22-amino acid peptide (P1) corresponding to the extreme C-terminal end and one of the F-actin binding sites of villin has been determined by 1H NMR and CD ... [more ▼]

The solution structure of a synthetic 22-amino acid peptide (P1) corresponding to the extreme C-terminal end and one of the F-actin binding sites of villin has been determined by 1H NMR and CD spectroscopy. The structure of this peptide was compared to that of a peptide in which lysine to glutamic acid substitutions were introduced at positions 17 and 19 (P11), abolishing F-actin binding. Both peptides are largely unstructured in aqueous solution. Changes observed in the NMR and CD spectra of both peptides are consistent with alpha-helix formation in trifluoroethanol/water mixtures. A set of 189 interproton distances derived from nuclear Overhauser enhancement (NOE) measurements, 17 phi-angle constraints obtained from 3JNH alpha coupling constants, as well as about 10 N ... O distance restraints deduced from amide proton exchange kinetics with deuterium, were used for the structure determination. The three-dimensional structure of P1 and P11 is characterized by two helical regions, one extending from residues 2 to 5 and a second covering residues 7 to 17. The central fragment, ranging from Leu-7 to Leu-15, is more stable. The C-terminal residues are less structured, particularly within peptide P11. The significance of these structural results is discussed in relation to the biological activity of villin. [less ▲]

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See detailA double-labelling fluorescent assay for concomitant measurements of [Ca2+]i and O2. production in human macrophages
Bueb, Jean-Luc UL; Gallois, A.; Schneider, J. C. et al

in Biochimica et Biophysica Acta (1995), 1244(1), 79-84

To measure intracellular free Ca2+ concentration ([Ca2+]i) and superoxide (O2) production in human alveolar macrophages, we used the fluorescent Ca2+ indicator fura-2 and the O2-sensitive dye ... [more ▼]

To measure intracellular free Ca2+ concentration ([Ca2+]i) and superoxide (O2) production in human alveolar macrophages, we used the fluorescent Ca2+ indicator fura-2 and the O2-sensitive dye dihydrorhodamine-123, which becomes fluorescent in its oxidized form, rhodamine-123. We describe a new double-dye technique whereby the kinetics of both [Ca2+]i levels and O2. production can be monitored simultaneously. This technique was developed in the dimethylsulfoxide-differentiated monocytic-like U-937 cell line (not equal to U-937), validated by comparison with single dye measurements and applied to human alveolar macrophages. The chemotactic peptide N-formyl-L-Methionyl-L-Leucyl-L-Phenylalanine induced in both cell types a similar transient elevation in [Ca2+]i, followed within seconds by a sustained increase in O2 production, which was however 4-fold weaker in not equal to U-937 cells. These results indicate that O2 production is an early event following the stimulation of human alveolar macrophages. This new double-dye technique may be relevant to other O2 ion-producing cells and could help to define more precisely the kinetics of the events leading to this biological response. [less ▲]

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See detailCalcitonin gene-related peptide released from dural nerve fibers mediates increase of meningeal blood flow in the rat.
Meßlinger, Karl; Hanesch, Ulrike UL; Kurosawa, Mieko et al

in Canadian Journal of Physiology & Pharmacology (1995)

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See detailPerformance Analysis of Direction Finding with Large Arrays and Finite Data
Viberg, Mats; Ottersten, Björn UL; Nehorai, A.

in IEEE Transactions on Signal Processing (1995)

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See detail« Mal di luna (Cyrano de Bergerac, Cavazzoni, Fellini)»
Roelens, Nathalie UL

in Romaniac (1995)

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See detailCloning and expression analysis of a novel mesodermally expressed cadherin.
Hoffmann, I.; Balling, Rudi UL

in Developmental Biology (1995), 169(1), 337-46

Cadherins are calcium-dependent cell adhesion molecules which show developmental and tissue-specific expression. Here we report the cloning of a mouse cadherin which is predominantly expressed in tissues ... [more ▼]

Cadherins are calcium-dependent cell adhesion molecules which show developmental and tissue-specific expression. Here we report the cloning of a mouse cadherin which is predominantly expressed in tissues of mesodermal origin. In contrast to other cadherins, cadherin-11 expression is largely restricted to mesenchymal tissues surrounding various organs but is not found in epithelia. Sequence analysis suggests that this cadherin is the mouse homologue of the previously reported human cadherin-11 and is a member of a cadherin subfamily, which is evolutionarily distinct from other cadherin subfamilies identified so far. [less ▲]

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See detailThe Spectrum Efficiency of a Base-Station Antenna Array System for Spatially Selective Transmission
Zetterberg, Per; Ottersten, Björn UL

in IEEE Transactions on Vehicular Technology (1995), 44(3), 651660

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See detailContributions de l’Union européenne à l’intégration régionale en Afrique subsaharienne : quelles spécificités ?
Bourgain, Arnaud UL

in Mondes en Développement (1995), 23(92), 43-56

The aim of this article is to observe the different bearings of the European Union contributions to the economic regional integration in subsaharan Africa. As the European Union is itself a regional ... [more ▼]

The aim of this article is to observe the different bearings of the European Union contributions to the economic regional integration in subsaharan Africa. As the European Union is itself a regional integration, it can be of some help in a debate dominated by the World Bank. The European Union gives more importance to the financement of projects with regional charachteristic than any others partners and doing so gives a full dimension to the support of the European developpement for regional inegration. The support perspectives to regional inegration seem to go towards an important commitment for regional programs, such as the project of budgetary convergence in West Africa. [less ▲]

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See detailUniversal relaxation behavior of classical liquid crystals at hypersonic frequencies.
Grammes, C.; Krüger, Jan-Kristian UL; Bohn, K.-P. et al

in Physical Review. E : Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics (1995), 51

Within this work we present comparative Brillouin and ultrasonic investigations of p-methoxybenzylidene p-(n-butylaniline), p-azoxyanisol, and 4-cyano-4’-pentyl-biphenyl performed in the vicinity of the ... [more ▼]

Within this work we present comparative Brillouin and ultrasonic investigations of p-methoxybenzylidene p-(n-butylaniline), p-azoxyanisol, and 4-cyano-4’-pentyl-biphenyl performed in the vicinity of the nematic-isotropic transition. We confirm the existence of a universal hypersonic relaxation mechanism of weak activation energy and a related significant splitting of the two principal longitudinal acoustic modes within the nematic phase. Brillouin refractometry is proposed as a method to determine the magnitude of the nematic order parameter simultaneously with the second-order elastic stiffness constants. The origin of the hypersonic anisotropy is discussed in terms of thermal relaxations and the evolution of the nematic order parameter. [less ▲]

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See detailStressimpfungstraining
Steffgen, Georges UL; de Boer, Claudia

in Psychologie und Sport -Schorndorf- (1995), 2(3), 83-86

Das Streßimpfungstraining (SIT) nach Meichenbaum (1991) stellt ein Verfahren dar, durch das gelernt wird, Streßsituationen bzw. emotional belastende Ereignisse angemessen zu bewältigen. Trainiert werden ... [more ▼]

Das Streßimpfungstraining (SIT) nach Meichenbaum (1991) stellt ein Verfahren dar, durch das gelernt wird, Streßsituationen bzw. emotional belastende Ereignisse angemessen zu bewältigen. Trainiert werden allgemein anwendbare Strategien. Einheitliches Merkmal dieser Strategien ist die Kompetenz, Problem- bzw. Streßsituationen frühzeitig zu erkennen und diese Situationen durch alternative/kognitive und verhaltensbezogene Bewältigungsmaßnahmen zu meistern. [less ▲]

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See detailCharacterization and developmental expression of Pax9, a paired-box-containing gene related to Pax1.
Neubuser, A.; Koseki, H.; Balling, Rudi UL

in Developmental Biology (1995), 170(2), 701-16

Pax9, a recently identified mouse paired-box-containing gene, is highly homologous to Pax1 and belongs to the same subfamily as Pax1, Hup48, PAX9, and pox meso. Two overlapping cDNA clones spanning the ... [more ▼]

Pax9, a recently identified mouse paired-box-containing gene, is highly homologous to Pax1 and belongs to the same subfamily as Pax1, Hup48, PAX9, and pox meso. Two overlapping cDNA clones spanning the entire coding region of Pax9 were isolated and sequenced. A comparison of the Pax1 and -9 protein sequences reveals a high degree of similarity even outside the paired box, while the carboxy-terminus of the two proteins diverges completely. We demonstrate that Pax9 can bind to the e5 sequence from the Drosophila even skipped promoter, which is also recognized by Pax1. We analyzed the expression of Pax9 during embryogenesis of wildtype, Undulated short-tail (Uns), and Danforth's short tail (Sd) mice. In wildtype embryos Pax9 is expressed in the pharyngeal pouches and their derivatives, the developing vertebral column, the tail, the head, and the limbs. Expression of Pax9 is unaffected in Uns embryos, in which the Pax1 gene is deleted, arguing that expression of Pax9 is not dependent on Pax1. The expression of Pax9 is lost in the caudal part of Sd homozygous embryos, suggesting that expression of Pax9 in the vertebral column is dependent on the notochord. These results indicate that both Pax9 and -1 may act in parallel during morphogenesis of the vertebral column. [less ▲]

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See detailFührt Ängstlichkeit und Ärgerneigung bei Leistungssportlern zu erhöhter Stressanfälligkeit?
Steffgen, Georges UL; Schwenkmezger, Peter

in Psychologie und Sport (1995), 2(1), 14-20

Abhängig von dem Ausmaß der personenspezifischen Streßanfälligkeit sind in emotional belastenden Situationen unterschiedliche Reaktionsweisen mit häufig negativen Folgen auf die sportliche Leistung ... [more ▼]

Abhängig von dem Ausmaß der personenspezifischen Streßanfälligkeit sind in emotional belastenden Situationen unterschiedliche Reaktionsweisen mit häufig negativen Folgen auf die sportliche Leistung feststellbar. Die vorliegende Studie an luxemburgischen Leistungssportlerinnen und -sportlern zeigt auf, inwieweit Ängstlichkeit, Ärgerneigung sowie Formen des Ärgerausdrucks und der Streßverarbeitung als Prädiktoren der Streßanfälligkeit von Bedeutung sind. Insbesondere der Befund, daß bei hoher Ärgerneigung ein geringer aktiver Kontrollversuch die Streßanfälligkeit erhöht, wird hinsichtlich seiner Bedeutung für den Leistungssport diskutiert. [less ▲]

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See detailStaatsgewalt und Kindsmord: zum sozialphilosophischen Hintergrund von Pestalozzis Schrift: "Über Gesetzgebung und Kindermord" (1780/83)
Tröhler, Daniel UL

in Schweizerische Zeitschrift fur Bildungswissenschaften = Rivista svizzera di scienze dell'educazione = Revue suisse des sciences de l'education (1995), (1), 34-35

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See detailAlgèbre de Schwartz d'un groupe de Lie nilpotent
Ludwig, Jean; Molitor-Braun, Carine UL

in Travaux Mathématiques (1995), 7

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See detailThe biological cascade leading to cardiac hypertrophy.
Neyses, Ludwig UL; Pelzer, T.

in European heart journal (1995), 16 Suppl N

Cardiac hypertrophy, one of the major risk factors in hypertension, is associated with a high incidence of congestive heart failure and sudden death. Despite efforts over the last 20 years, the underlying ... [more ▼]

Cardiac hypertrophy, one of the major risk factors in hypertension, is associated with a high incidence of congestive heart failure and sudden death. Despite efforts over the last 20 years, the underlying molecular mechanisms of cardiac hypertrophy are still poorly understood, thus making it difficult to develop new therapeutic strategies. A growing body of evidence suggests that cardiac hypertrophy results from mechanical stress that triggers paracrine and autocrine signal transduction pathways. Furthermore, whereas hypertrophy leads to isoform switches in some contractile proteins, increased protein synthesis is largely based on increased translational capacity. Cardiac growth under physiological as well as pathological conditions is regulated by several recently identified transcription factors. Among the factors that are capable of transmitting hypertrophic stimuli to the nucleus is the early growth response gene-1 (Egr-1). Whereas female gender is already an established cardioprotective factor in clinical trials, some very recent data indicate that oestrogens and the nuclear oestrogen receptor may directly modulate gene expression in the development of cardiac hypertrophy. Future pharmacological interventions could be directed towards modifying the nuclear signal transduction cascade involving multiple protein kinases and phosphatases. [less ▲]

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See detailAPO-I-mediated apoptosis in normal and malignant lymphocytes
Dhein, J.; Behrmann, Iris UL; Daniel, P. T. et al

in Biochemical Society Transactions (1995), 22(3), 598-600

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See detailSymmetry Lie algebra of the two body systems with a Dirac oscillator interaction
del Sol Mesa, Antonio UL

in Revista Mexicana de Física (1995)

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See detailPanorama de jurisprudence en matière d'indemnisation du dommage
Ravarani, Georges UL

in Pasicrisie Luxembourgeoise: Recueil Trimestriel de la Jurisprudence Luxembourgeoise (1995), (29), 153232

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See detailWandlungen politisch motivierter Gewalt in der Bundesrepublik
Willems, Helmut UL; Eckert, Roland

in Gruppendynamik (1995), 26. Jg(1), 89-123

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See detailDie Wirtschaftswunder in Ostasien, Eine Suche nach Erklärungen
Klump, Rainer UL; Menkhoff, Lukas

in IFO-Studien (1995)

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See detailIon Sensitive Field Effect Transistors with Ultrathin Langmuir-Blodgett Membranes
Schöning, M. J.; Sauke, M.; Steffen, A. et al

in Sensors and actuators. B, Chemical (1995), 26-27(1995), 325-328

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See detailÄrgerbewältigungstraining
Steffgen, Georges UL; Schwenkmezger, Peter

in Psychologie und Sport (1995), 2(3), 89-95

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See detailPostmodernism and the repoliticization of education.
Biesta, Gert UL

in Interchange (1995), 26

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See detailMorphine, 5-HT 2 and 5-HT 3 recpror antagonists reduce c-Fos expresion in the trigeminal nuclear complex follwing noxious chemical stimulation of the rat nasal mucosa
Ebersberger, Andrea; Anton, Fernand UL; Tölle, Thomas et al

in Brain Research (1995), 676(2), 336-342

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See detail[Molecular adaptation of the heart to hypertension].
Neyses, Ludwig UL; Pelzer, T.

in Zeitschrift fur Kardiologie (1995), 84 Suppl 4

Because myocardial hypertrophy is an independent risk factor for sudden death and cardiac failure, it is important to understand its molecular mechanisms to be able to devise new treatment strategies in ... [more ▼]

Because myocardial hypertrophy is an independent risk factor for sudden death and cardiac failure, it is important to understand its molecular mechanisms to be able to devise new treatment strategies in the future. Stretch is the putative primary stimulus triggering hypertrophy. Further signal transduction steps such as auto- and paracrine secretion of growth factors or transmission via the cytoskeleton are beginning to be unravelled. Subsequent to hypertrophic stimuli some important proteins undergo an isoform switch; questitatively, however, the most important step is an increase in translational capacity for each mRNA. Myocardial specific gene expression is achieved by coordinate interaction of several transcription factors, some of which may be involved in nuclear transmission of hypertrophic signals. One of the genes capable of transmitting hypertrophic signals is the "early growth response gene-1 (Egr-1)". We have also shown that nuclear estrogen receptors act as transcription factors in the myocardium and may therefore be involved in the sex-specific modulation of cardiac hypertrophy. At present, pharmacological interventions aiming at reduction of hypertrophy by interfering with the signal transduction pathway from the membrane to the nucleus are actively being sought. These transduction pathways are composed of a series of proteinkinases which may be amenable to drugs. In the future, gene transfer may become an option for treatment. [less ▲]

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See detailRez. zu Hermann Ehmann: Jugendsprache und Dialekt
Sieburg, Heinz UL

in Zeitschrift für Deutsche Philologie (1995), 114

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See detailHormonal induction of an immediate-early gene response in myogenic cell lines--a paradigm for heart growth.
Maass, A.; Grohe, C.; Kubisch, C. et al

in European heart journal (1995), 16 Suppl C

Cardiac hypertrophy is characterized by growth of myocardial cells without proliferation. Many endo- paracrine stimuli such as angiotensin II, endothelin, alpha 1-adrenergic agonists, and insulin have ... [more ▼]

Cardiac hypertrophy is characterized by growth of myocardial cells without proliferation. Many endo- paracrine stimuli such as angiotensin II, endothelin, alpha 1-adrenergic agonists, and insulin have been shown to be able to induce cardiac hypertrophy either in vivo or in vitro. We have used the myoblast model of differentiation and proliferation to determine nuclear signal transduction mechanisms in muscle and (by analogy) cardiac growth. The first nuclear event known to occur when a growth stimulus acts upon a cell is induction of a family of immediate-early genes. Our group focused on the role of one of these genes, the early growth response gene-1 (Egr-1). We have shown that this gene is induced in isolated adult cardiac myocytes in the presence of endothelin. An anti-sense oligonucleotide complementary to the first six codons of the Egr-1 mRNA abolishes the stimulation of protein synthesis induced by endothelin. In the present study we further characterized paracrine growth stimuli in the myogenic cell line Sol8, which was used as a paradigm to further investigate mechanisms of paracrine growth induction. We demonstrated that a variety of candidate endo- paracrine stimuli for the induction of cardiac hypertrophy induced the Egr-1 messenger RNA in the myogenic cell line Sol8. Among these are endothelin, insulin, basic fibroblast growth factor, and platelet-derived growth factor BB (PDGF BB). We conclude: (1) In analogy to the myocardium, these growth factors act upon myoblasts. (2) This line appears to be a suitable model for the molecular characterization of Egr-1 target genes. [less ▲]

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See detailEXPLORING THE MYCOPLASMA-CAPRICOLUM GENOME - A MINIMAL CELL REVEALS ITS PHYSIOLOGY
BORK, P.; OUZOUNIS, C.; CASARI, G. et al

in Molecular Microbiology (1995), 16(5), 955-967

We report on the analysis of 214 kb of the parasitic eubacterium Mycoplasma capricolum sequenced by genomic walking techniques. The 287 putative proteins detected to date represent about half of the ... [more ▼]

We report on the analysis of 214 kb of the parasitic eubacterium Mycoplasma capricolum sequenced by genomic walking techniques. The 287 putative proteins detected to date represent about half of the estimated total number of 500 predicted for this organism. A large fraction of these (75%) can be assigned a likely function as a result of similarity searches. Several important features of the functional organization of this small genome are already apparent. Among these are (i) the expected relatively large number of enzymes involved in metabolic transport and activation, for efficient use of host cell nutrients; (ii) the presence of anabolic enzymes; (iii) the unexpected diversity of enzymes involved in DNA replication and repair; and (iv) a sizeable number of orthologues (82 so far) in Escherichia coil. This survey is beginning to provide a detailed view of how M. capricolum manages to maintain essential cellular processes with a genome much smaller than that of its bacterial relatives. [less ▲]

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See detailEditorial
Tröhler, Daniel UL

in Neue Pestalozzi-Blätter (1995), 1

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See detailA Subspace Fitting Method for Identification of Linear State Space Models
Swindlehurst, A. L.; Roy, R.; Ottersten, Björn UL et al

in IEEE Transactions on Automatic Control (1995)

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See detailPax-1, a regulator of sclerotome development is induced by notochord and floor plate signals in avian embryos.
Ebensperger, C.; Wilting, J.; Brand-Saberi, B. et al

in Anatomy & Embryology (1995), 191(4), 297-310

Pax-1 encodes for a DNA-binding transcriptional activator that was originally discovered in murine embryos using a probe from the Drosophila paired-box-containing gene, gooseberry-distal. We have cloned ... [more ▼]

Pax-1 encodes for a DNA-binding transcriptional activator that was originally discovered in murine embryos using a probe from the Drosophila paired-box-containing gene, gooseberry-distal. We have cloned the avian Pax-1 gene as a basis for experimental studies of the induction of Pax-1 in the paraxial mesoderm. The amino acid sequence of the paired-domain is exactly the same in the quail and mouse, whereas outside the paired-domain there is 61% homology. Starting at about the eight-somite stage, quail Pax-1 is expressed in the paraxial mesoderm in a craniocaudal sequence. The unsegmented paraxial mesoderm and the two most recently formed somites do not express Pax-1. In the epithelial somite, the somitocoele cells and the cells of the ventral two-thirds of the epithelial wall are positive. As soon as the sclerotome is formed, only a subset of sclerotome cells expresses Pax-1. These are the cells that migrate towards the notochord to form the perinotochordal tube. Expression then becomes restricted to the intervertebral discs, the perichondrium of the vertebral bodies and the connective tissue surrounding the spinal ganglia. Additional expression domains are found in the scapula and the pelvic region, distinct areas of the head, and the epithelium of the second to the fourth visceral pouch. In later stages the thymus is positive. In vitro and in vivo experiments show that the notochord induces Pax-1 in the paraxial mesoderm, but limb bud mesoderm is not competent to respond to notochordal signals. Floor plate is also capable of inducing Pax-1 expression in sclerotome cells. Our studies show that in competent cells of the paraxial mesoderm, Pax-1 is a mediator of signals emanating from the notochord and the floor plate. [less ▲]

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See detailA gene for autosomal dominant sacral agenesis maps to the holoprosencephaly region at 7q36.
Lynch, S. A.; Bond, P. M.; Copp, A. J. et al

in Nature Genetics (1995), 11(1), 93-5

Sacral agenesis is a rare disorder of uncertain incidence that has been reported in diverse populations. Although usually sporadic and most commonly associated with maternal diabetes, there is a ... [more ▼]

Sacral agenesis is a rare disorder of uncertain incidence that has been reported in diverse populations. Although usually sporadic and most commonly associated with maternal diabetes, there is a hereditary form which may occur in isolation or with a presacral mass (anterior meningocele and/or presacral teratoma) and anorectal abnormalities, which constitute the Currarino triad (MIM 176450). The radiological hallmark of hereditary sacral agenesis is a hemi-sacrum (sickle-shaped sacrum) with intact first sacral vertebra. Bowel obstruction is the usual neonatal presentation, but, unlike other neural tube defects, adult presentation is not uncommon. The major pathology is confined to the pelvic cavity and may present as a space-occupying lesion or meningitis due to ascending infection. All recurrences in families have been compatible with autosomal dominant inheritance except for those associated with the isomerism gene at Xq24-q27.1 (ref. 3). Several associated cytogenetic defects have been reported, including 7q deletions. Previous studies failed to detect linkage to HLA markers, but we now present evidence for a location on 7q36. The same region also contains a gene for holoprosencephaly, an early malformation of the extreme rostral end of the neural tube. [less ▲]

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See detailArray Processing in Correlated Noise Fields Based on Instrumental Variables and Subspace Fitting
Viberg, Mats; Stoica, Petre; Ottersten, Björn UL

in IEEE Transactions on Signal Processing (1995), 43

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See detailSecond-order elasticity of liquid crystals within their nematic state at high frequencies
Krüger, Jan-Kristian UL; Grammes, C.; Jiménez, R. et al

in Physical Review. E : Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics (1995), 51(3), 2115-2128

Within this work we present Brillouin and ultrasonic investigations performed on the liquid crystals p-methoxybenzylidene p-(n-butylaniline) (MBBA), p-azoxyanisol (PAA), 4-cyano-4-n-alkylbiphenyles (nCB ... [more ▼]

Within this work we present Brillouin and ultrasonic investigations performed on the liquid crystals p-methoxybenzylidene p-(n-butylaniline) (MBBA), p-azoxyanisol (PAA), 4-cyano-4-n-alkylbiphenyles (nCB), and 4-n-pentoxybenzylidene-4'-n-octoaniline (5O.8). Special attention has been paid to the evolution of a significant splitting of the two longitudinal polarized acoustic modes within the nematic phase. Angle-resolving Brillouin spectroscopy allowed the determination of the complete stiffness tensors and hence a discussion of the propagation of quasitransverse polarized acoustic modes in the nematic state of liquid crystals. We analyze the behavior of the eigenvectors of the relevant acoustic modes and discuss their significance for the propagation of quasishear modes. For 5O.8 we report an acoustic instability within its nematic state. We confirm the existence of a universal thermal relaxation mechanism of weak activation energy for the nematic state of classical liquid crystals. The observed hypersonic anisotropy is discussed in terms of that relaxation mechanism and is compared with that of glass-forming liquid crystals. [less ▲]

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See detailS.A.S. : un exemple à suivre ?
Corbisier, Isabelle UL; Nicaise, Pierre

in Le droit des affaires = Het ondernemingsrecht (1994), (33), 43-80

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See detailObservations sous Cass., 20 janvier 1994 (n° 6653)
Corbisier, Isabelle UL

in Revue Pratique des Sociétés Civiles et Commerciales (1994), (4), 408-409

Commentaire de l'une des rares décisions précisant que la règle stipulant l'irrecevabilité de l'action en justice d'une société demeurée en défaut de procéder au dépôt de son acte constitutif au greffe du ... [more ▼]

Commentaire de l'une des rares décisions précisant que la règle stipulant l'irrecevabilité de l'action en justice d'une société demeurée en défaut de procéder au dépôt de son acte constitutif au greffe du tribunal compétent n'est pas d'ordre public [less ▲]

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