GeneCrunch: Experiences on the SGI POWER CHALLENGEarray with Bioinformatics applications

in Supercomputer 96 : Anwendungen, Architekturen, Trends (1996)

Analyzing genomic data is a computationally intensive and complicated process in which scientists must typically choose among multiple databases and analysis methods and make expert judgements inspecting ... [more ▼]

Analyzing genomic data is a computationally intensive and complicated process in which scientists must typically choose among multiple databases and analysis methods and make expert judgements inspecting multiple results. GeneQuiz, an automated software system for large scale genome analysis developed at the EMBL/EBI, tackles this problem by using an automated, rigorous, rule-based system to select among the results of sequence analysis and database searches, builds informative annotation and aims at predicting the function of new genes. In a demonstration project more than 6000 proteins from the Baker’s yeast, for which the complete genomic sequence was completed in 1996, were analyzed on a Silicon Graphics POWERCHALLENGEarray with 64 processors (R8000 @90 MHz) so that the analysis could be completed in 3 days. The results of the analysis were published on two web servers as they were computed. [less ▲]

Messung des Selbstwertgefühls: Befunde zu Reliabilität, Validität und Stabilität der Rosenberg-Skala.

in Focus Diagnostica (1996), 42(3)

Bespreking van Max Velthuis, Kikker is verliefd.

in Comenius (1996), 16

A Restriction Theorem for Ideals in the Schwartz Algebra of a Nilpotent Lie Group

in Archiv der Mathematik [=ADM] (1996), 67(3), 199-210

Die Pädagogik des Fin de Siècle - een impressie

in Nieuwsbrief BNVGOO (1995), 4

Identiteit, cultuur en opvoeding. Impressies van het vierde congres van het International Network of Philosophers of Education

in Pedagogisch Tijdschrift: Forum voor Opvoedkunde (1995), 20(1), 57-64

Von Mäusen und Menschen In: “Genetische Determinierung: Schicksal aus den Genen?”

in GSF-Mensch und Umwelt (1995), (10), 17-23

On the institutional determinants of economic development. Lessons from a stochastic neoclassical growth model

in Jahrbuch für Wirtschaftswissenschaften / Review of Economics (1995)

Erstspracherwerb als Thema des akademischen Unterrichts

in Germanistik. Publications du Centre Universitaire du Luxembourg. Lettres Allemandes (1995)

Pestalozzi für den Schulgebrauch

in Schweizerische Lehrerinnen- und Lehrer-Zeitung (1995), 140(23-24), 15-15

Kleist speichern. Zur Verzeichnung des handschriftlichen Nachlasses von Georg Minde-Pouet

in Brandenburger Kleist-Blätter (1995), 8

Lange Wellen“ der Unternehmenskonjunktur: Eine Untersuchung langfristiger Umsatz- und Innovationszyklen der Druckmaschinenfabrik Koenig & Bauer in Würzburg (1817-1992)

in Zeitschrift für Unternehmensgeschichte (1995)

Opvoeding en intersubjectiviteit. Over de structuur en identiteit van de pedagogiek van John Dewey.

in Comenius (1995), 15

An Extended Quantum Model for Porous Silicon Formation

in Journal of the Electrochemical Society (1995), 142(1995), 615-620

The role of APO-1-mediated apoptosis in the immune system

in Immunological Reviews (1995), 142

Development, Pattern and Causes of Violence against Foreigners in Germany: Social and Biographical Characteristics of Perpetrators and the Process of Escalation

in Terrorism & Political Violence (1995), 7(1), 162-181

Produktivitätslücken, Konvergenzprozesse und die Rolle der Wirtschaftsordnung: Anmerkungen zur „Catching up“-Hypothese

in Zeitschrift für Wirtschaftspolitik (1995)

Jacobiennes de certaines courbes de genre 2 : torsion et simplicité

in Journal de Théorie des Nombres de Bordeaux (1995), 7

Assignment of the paired box gene Pax1 to rat chromosome 3.

in Mammalian Genome (1995), 6(9), 666-7

Industrial linear optimization problems solved by constraint logic programming

in European Journal of Operational Research (1995), 84(1), 82-95

In this article we illustrate that Constraint Logic Programming (CLP) systems allow easy expression and solutions of constrained decision problems. CLP solutions for two industrial linear optimization ... [more ▼]

In this article we illustrate that Constraint Logic Programming (CLP) systems allow easy expression and solutions of constrained decision problems. CLP solutions for two industrial linear optimization problems are discussed: - a mixed linear multiple criteria selection problem implemented in the linear rational Prolog III solver, and - a linear integer multiple criteria location problem, particularly adapted to the CHIP solver. [less ▲]

«Een Eco-grafie van de cultroman»

in ALW-Cahier (1995)

Right-wing extremism, racism or youth violence? Explaining violence against foreigners in Germany

in New Community (1995), 21(4), 501-523

The Imagination of a Radical Democracy. Een interview met Henry Giroux.

in Comenius (1995), 15(2), 194-205

Provisional Utopias in a Post-Colonial World. Een interview met Peter McLaren.

in Comenius (1995), 15(3), 335-347

Fast and sensitive search of information databases for biological relationships

in Statustagung des BMBF, HPSC 95, Stand und Perspektiven des Parallelen Höchstleistungsrechnens und seiner Anwendungen (1995)

Sequence comparison has become an essential and standard tool in the analysis of genomic data. Genome projects will decipher much of the genetic information in many organisms, including humans. As a ... [more ▼]

Sequence comparison has become an essential and standard tool in the analysis of genomic data. Genome projects will decipher much of the genetic information in many organisms, including humans. As a result, the computational cost of databank searches will increase dramatically. In addition, the search for biologically meaningful homology between a newly determined sequence and sequences already stored in the various databanks becomes increasingly important as most of the new data will be in raw, not understood form. The detection of sufficient similarity between a newly determined sequence to a protein of know function or even known 3D-structure in a databank allows one to transfer most of the knowledge from one sequence to the other. The result can be enormous savings in genetic and biochemical laboratory efforts. [less ▲]

Possible Involvement of Gaba-B receptors in the sedative effects of nicotine in mice

in Journal of Psychopharmacology (1995), 9(3), 51

Somatostatin-like immunoreactivity in primary afferents of the medial articular nerve and colocalization with substance P in the cat

in Journal of Comparative Neurology (1995), 354

A double-labelling fluorescent assay for concomitant measurements of [Ca2+]i and O2. production in human macrophages

in Biochimica et Biophysica Acta (1995), 1244(1), 79-84

To measure intracellular free Ca2+ concentration ([Ca2+]i) and superoxide (O2) production in human alveolar macrophages, we used the fluorescent Ca2+ indicator fura-2 and the O2-sensitive dye ... [more ▼]

To measure intracellular free Ca2+ concentration ([Ca2+]i) and superoxide (O2) production in human alveolar macrophages, we used the fluorescent Ca2+ indicator fura-2 and the O2-sensitive dye dihydrorhodamine-123, which becomes fluorescent in its oxidized form, rhodamine-123. We describe a new double-dye technique whereby the kinetics of both [Ca2+]i levels and O2. production can be monitored simultaneously. This technique was developed in the dimethylsulfoxide-differentiated monocytic-like U-937 cell line (not equal to U-937), validated by comparison with single dye measurements and applied to human alveolar macrophages. The chemotactic peptide N-formyl-L-Methionyl-L-Leucyl-L-Phenylalanine induced in both cell types a similar transient elevation in [Ca2+]i, followed within seconds by a sustained increase in O2 production, which was however 4-fold weaker in not equal to U-937 cells. These results indicate that O2 production is an early event following the stimulation of human alveolar macrophages. This new double-dye technique may be relevant to other O2 ion-producing cells and could help to define more precisely the kinetics of the events leading to this biological response. [less ▲]

Calcitonin gene-related peptide released from dural nerve fibers mediates increase of meningeal blood flow in the rat.

in Canadian Journal of Physiology & Pharmacology (1995)

Eintragungen in das Stammbuch von David Matthias Frank während seines Besuches der Pestalozzischen Anstalt in Yverdon

in Neue Pestalozzi-Blätter (1995), 1(1), 15-17

Performance Analysis of Direction Finding with Large Arrays and Finite Data

in IEEE Transactions on Signal Processing (1995)

Cloning and expression analysis of a novel mesodermally expressed cadherin.

in Developmental Biology (1995), 169(1), 337-46

Cadherins are calcium-dependent cell adhesion molecules which show developmental and tissue-specific expression. Here we report the cloning of a mouse cadherin which is predominantly expressed in tissues ... [more ▼]

Cadherins are calcium-dependent cell adhesion molecules which show developmental and tissue-specific expression. Here we report the cloning of a mouse cadherin which is predominantly expressed in tissues of mesodermal origin. In contrast to other cadherins, cadherin-11 expression is largely restricted to mesenchymal tissues surrounding various organs but is not found in epithelia. Sequence analysis suggests that this cadherin is the mouse homologue of the previously reported human cadherin-11 and is a member of a cadherin subfamily, which is evolutionarily distinct from other cadherin subfamilies identified so far. [less ▲]

Contributions de l’Union européenne à l’intégration régionale en Afrique subsaharienne : quelles spécificités ?

in Mondes en Développement (1995), 23(92), 43-56

The aim of this article is to observe the different bearings of the European Union contributions to the economic regional integration in subsaharan Africa. As the European Union is itself a regional ... [more ▼]

The aim of this article is to observe the different bearings of the European Union contributions to the economic regional integration in subsaharan Africa. As the European Union is itself a regional integration, it can be of some help in a debate dominated by the World Bank. The European Union gives more importance to the financement of projects with regional charachteristic than any others partners and doing so gives a full dimension to the support of the European developpement for regional inegration. The support perspectives to regional inegration seem to go towards an important commitment for regional programs, such as the project of budgetary convergence in West Africa. [less ▲]

Stressimpfungstraining

in Psychologie und Sport -Schorndorf- (1995), 2(3), 83-86

Das Streßimpfungstraining (SIT) nach Meichenbaum (1991) stellt ein Verfahren dar, durch das gelernt wird, Streßsituationen bzw. emotional belastende Ereignisse angemessen zu bewältigen. Trainiert werden ... [more ▼]

Das Streßimpfungstraining (SIT) nach Meichenbaum (1991) stellt ein Verfahren dar, durch das gelernt wird, Streßsituationen bzw. emotional belastende Ereignisse angemessen zu bewältigen. Trainiert werden allgemein anwendbare Strategien. Einheitliches Merkmal dieser Strategien ist die Kompetenz, Problem- bzw. Streßsituationen frühzeitig zu erkennen und diese Situationen durch alternative/kognitive und verhaltensbezogene Bewältigungsmaßnahmen zu meistern. [less ▲]

Characterization and developmental expression of Pax9, a paired-box-containing gene related to Pax1.

in Developmental Biology (1995), 170(2), 701-16

Pax9, a recently identified mouse paired-box-containing gene, is highly homologous to Pax1 and belongs to the same subfamily as Pax1, Hup48, PAX9, and pox meso. Two overlapping cDNA clones spanning the ... [more ▼]

Pax9, a recently identified mouse paired-box-containing gene, is highly homologous to Pax1 and belongs to the same subfamily as Pax1, Hup48, PAX9, and pox meso. Two overlapping cDNA clones spanning the entire coding region of Pax9 were isolated and sequenced. A comparison of the Pax1 and -9 protein sequences reveals a high degree of similarity even outside the paired box, while the carboxy-terminus of the two proteins diverges completely. We demonstrate that Pax9 can bind to the e5 sequence from the Drosophila even skipped promoter, which is also recognized by Pax1. We analyzed the expression of Pax9 during embryogenesis of wildtype, Undulated short-tail (Uns), and Danforth's short tail (Sd) mice. In wildtype embryos Pax9 is expressed in the pharyngeal pouches and their derivatives, the developing vertebral column, the tail, the head, and the limbs. Expression of Pax9 is unaffected in Uns embryos, in which the Pax1 gene is deleted, arguing that expression of Pax9 is not dependent on Pax1. The expression of Pax9 is lost in the caudal part of Sd homozygous embryos, suggesting that expression of Pax9 in the vertebral column is dependent on the notochord. These results indicate that both Pax9 and -1 may act in parallel during morphogenesis of the vertebral column. [less ▲]

Protection des incapables. Mariage. Divorce. Filiation. Adoption, Législation comparée, Grand-Duché de Luxembourg

in JurisClasseur Droit Comparé (1995)

Staatsgewalt und Kindsmord: zum sozialphilosophischen Hintergrund von Pestalozzis Schrift: "Über Gesetzgebung und Kindermord" (1780/83)

in Schweizerische Zeitschrift fur Bildungswissenschaften = Rivista svizzera di scienze dell'educazione = Revue suisse des sciences de l'education (1995), (1), 34-35

The biological cascade leading to cardiac hypertrophy.

in European heart journal (1995), 16 Suppl N

Cardiac hypertrophy, one of the major risk factors in hypertension, is associated with a high incidence of congestive heart failure and sudden death. Despite efforts over the last 20 years, the underlying ... [more ▼]

Cardiac hypertrophy, one of the major risk factors in hypertension, is associated with a high incidence of congestive heart failure and sudden death. Despite efforts over the last 20 years, the underlying molecular mechanisms of cardiac hypertrophy are still poorly understood, thus making it difficult to develop new therapeutic strategies. A growing body of evidence suggests that cardiac hypertrophy results from mechanical stress that triggers paracrine and autocrine signal transduction pathways. Furthermore, whereas hypertrophy leads to isoform switches in some contractile proteins, increased protein synthesis is largely based on increased translational capacity. Cardiac growth under physiological as well as pathological conditions is regulated by several recently identified transcription factors. Among the factors that are capable of transmitting hypertrophic stimuli to the nucleus is the early growth response gene-1 (Egr-1). Whereas female gender is already an established cardioprotective factor in clinical trials, some very recent data indicate that oestrogens and the nuclear oestrogen receptor may directly modulate gene expression in the development of cardiac hypertrophy. Future pharmacological interventions could be directed towards modifying the nuclear signal transduction cascade involving multiple protein kinases and phosphatases. [less ▲]

Symmetry Lie algebra of the two body systems with a Dirac oscillator interaction

in Revista Mexicana de Física (1995)

Observations - La tierce complicité de la violation d'un pacte de préférence notifié à la société (note sous Cass. fr., 26 avril 1994) (n° 6664)

in Revue Pratique des Sociétés Civiles et Commerciales (1995), (1), 59

Die Wirtschaftswunder in Ostasien, Eine Suche nach Erklärungen

in IFO-Studien (1995)

Ärgerbewältigungstraining

in Psychologie und Sport (1995), 2(3), 89-95

Observations - Une illustration de l'autonomie relative des dispostions statutaires et extrastatutaires et ce au détriment des premières (note sous Trib. suprême espagnol, 10 février 1992) (n° 6663)

in Revue Pratique des Sociétés Civiles et Commerciales (1995), (1), 45-56

[Molecular adaptation of the heart to hypertension].

in Zeitschrift fur Kardiologie (1995), 84 Suppl 4

Because myocardial hypertrophy is an independent risk factor for sudden death and cardiac failure, it is important to understand its molecular mechanisms to be able to devise new treatment strategies in ... [more ▼]

Because myocardial hypertrophy is an independent risk factor for sudden death and cardiac failure, it is important to understand its molecular mechanisms to be able to devise new treatment strategies in the future. Stretch is the putative primary stimulus triggering hypertrophy. Further signal transduction steps such as auto- and paracrine secretion of growth factors or transmission via the cytoskeleton are beginning to be unravelled. Subsequent to hypertrophic stimuli some important proteins undergo an isoform switch; questitatively, however, the most important step is an increase in translational capacity for each mRNA. Myocardial specific gene expression is achieved by coordinate interaction of several transcription factors, some of which may be involved in nuclear transmission of hypertrophic signals. One of the genes capable of transmitting hypertrophic signals is the "early growth response gene-1 (Egr-1)". We have also shown that nuclear estrogen receptors act as transcription factors in the myocardium and may therefore be involved in the sex-specific modulation of cardiac hypertrophy. At present, pharmacological interventions aiming at reduction of hypertrophy by interfering with the signal transduction pathway from the membrane to the nucleus are actively being sought. These transduction pathways are composed of a series of proteinkinases which may be amenable to drugs. In the future, gene transfer may become an option for treatment. [less ▲]

Hormonal induction of an immediate-early gene response in myogenic cell lines--a paradigm for heart growth.

in European heart journal (1995), 16 Suppl C

Cardiac hypertrophy is characterized by growth of myocardial cells without proliferation. Many endo- paracrine stimuli such as angiotensin II, endothelin, alpha 1-adrenergic agonists, and insulin have ... [more ▼]

Cardiac hypertrophy is characterized by growth of myocardial cells without proliferation. Many endo- paracrine stimuli such as angiotensin II, endothelin, alpha 1-adrenergic agonists, and insulin have been shown to be able to induce cardiac hypertrophy either in vivo or in vitro. We have used the myoblast model of differentiation and proliferation to determine nuclear signal transduction mechanisms in muscle and (by analogy) cardiac growth. The first nuclear event known to occur when a growth stimulus acts upon a cell is induction of a family of immediate-early genes. Our group focused on the role of one of these genes, the early growth response gene-1 (Egr-1). We have shown that this gene is induced in isolated adult cardiac myocytes in the presence of endothelin. An anti-sense oligonucleotide complementary to the first six codons of the Egr-1 mRNA abolishes the stimulation of protein synthesis induced by endothelin. In the present study we further characterized paracrine growth stimuli in the myogenic cell line Sol8, which was used as a paradigm to further investigate mechanisms of paracrine growth induction. We demonstrated that a variety of candidate endo- paracrine stimuli for the induction of cardiac hypertrophy induced the Egr-1 messenger RNA in the myogenic cell line Sol8. Among these are endothelin, insulin, basic fibroblast growth factor, and platelet-derived growth factor BB (PDGF BB). We conclude: (1) In analogy to the myocardium, these growth factors act upon myoblasts. (2) This line appears to be a suitable model for the molecular characterization of Egr-1 target genes. [less ▲]

Editorial

in Neue Pestalozzi-Blätter (1995), 1

Pax-1, a regulator of sclerotome development is induced by notochord and floor plate signals in avian embryos.

in Anatomy & Embryology (1995), 191(4), 297-310

Pax-1 encodes for a DNA-binding transcriptional activator that was originally discovered in murine embryos using a probe from the Drosophila paired-box-containing gene, gooseberry-distal. We have cloned ... [more ▼]

Pax-1 encodes for a DNA-binding transcriptional activator that was originally discovered in murine embryos using a probe from the Drosophila paired-box-containing gene, gooseberry-distal. We have cloned the avian Pax-1 gene as a basis for experimental studies of the induction of Pax-1 in the paraxial mesoderm. The amino acid sequence of the paired-domain is exactly the same in the quail and mouse, whereas outside the paired-domain there is 61% homology. Starting at about the eight-somite stage, quail Pax-1 is expressed in the paraxial mesoderm in a craniocaudal sequence. The unsegmented paraxial mesoderm and the two most recently formed somites do not express Pax-1. In the epithelial somite, the somitocoele cells and the cells of the ventral two-thirds of the epithelial wall are positive. As soon as the sclerotome is formed, only a subset of sclerotome cells expresses Pax-1. These are the cells that migrate towards the notochord to form the perinotochordal tube. Expression then becomes restricted to the intervertebral discs, the perichondrium of the vertebral bodies and the connective tissue surrounding the spinal ganglia. Additional expression domains are found in the scapula and the pelvic region, distinct areas of the head, and the epithelium of the second to the fourth visceral pouch. In later stages the thymus is positive. In vitro and in vivo experiments show that the notochord induces Pax-1 in the paraxial mesoderm, but limb bud mesoderm is not competent to respond to notochordal signals. Floor plate is also capable of inducing Pax-1 expression in sclerotome cells. Our studies show that in competent cells of the paraxial mesoderm, Pax-1 is a mediator of signals emanating from the notochord and the floor plate. [less ▲]

Array Processing in Correlated Noise Fields Based on Instrumental Variables and Subspace Fitting

in IEEE Transactions on Signal Processing (1995), 43

Second-order elasticity of liquid crystals within their nematic state at high frequencies

in Physical Review. E : Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics (1995), 51(3), 2115-2128

Within this work we present Brillouin and ultrasonic investigations performed on the liquid crystals p-methoxybenzylidene p-(n-butylaniline) (MBBA), p-azoxyanisol (PAA), 4-cyano-4-n-alkylbiphenyles (nCB ... [more ▼]

Within this work we present Brillouin and ultrasonic investigations performed on the liquid crystals p-methoxybenzylidene p-(n-butylaniline) (MBBA), p-azoxyanisol (PAA), 4-cyano-4-n-alkylbiphenyles (nCB), and 4-n-pentoxybenzylidene-4'-n-octoaniline (5O.8). Special attention has been paid to the evolution of a significant splitting of the two longitudinal polarized acoustic modes within the nematic phase. Angle-resolving Brillouin spectroscopy allowed the determination of the complete stiffness tensors and hence a discussion of the propagation of quasitransverse polarized acoustic modes in the nematic state of liquid crystals. We analyze the behavior of the eigenvectors of the relevant acoustic modes and discuss their significance for the propagation of quasishear modes. For 5O.8 we report an acoustic instability within its nematic state. We confirm the existence of a universal thermal relaxation mechanism of weak activation energy for the nematic state of classical liquid crystals. The observed hypersonic anisotropy is discussed in terms of that relaxation mechanism and is compared with that of glass-forming liquid crystals. [less ▲]

Observations sous Cass., 20 janvier 1994 (n° 6653)

in Revue Pratique des Sociétés Civiles et Commerciales (1994), (4), 408-409

Commentaire de l'une des rares décisions précisant que la règle stipulant l'irrecevabilité de l'action en justice d'une société demeurée en défaut de procéder au dépôt de son acte constitutif au greffe du ... [more ▼]

Commentaire de l'une des rares décisions précisant que la règle stipulant l'irrecevabilité de l'action en justice d'une société demeurée en défaut de procéder au dépôt de son acte constitutif au greffe du tribunal compétent n'est pas d'ordre public [less ▲]