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See detailVergleichsprozesse in der Auseinandersetzung mit schweren körperlicher Erkrankungen
Filipp, Sigrun-Heide; Ferring, Dieter UL

in Psychotherapie im Dialog (2002), 3(1), 2-12

Das individuelle Bewaeltigungsverhalten im Umfeld einer Krebserkrankung wird analysiert. Dabei wird insbesondere auf die Rolle von temporalen und sozialen Vergleichsprozessen eingegangen. Diese beiden ... [more ▼]

Das individuelle Bewaeltigungsverhalten im Umfeld einer Krebserkrankung wird analysiert. Dabei wird insbesondere auf die Rolle von temporalen und sozialen Vergleichsprozessen eingegangen. Diese beiden Vergleichsprozesse stehen im Dienste der kognitiven Adaptation an die durch die Krankheit veraenderte Lebenssituation und lassen sich in einem uebergeordneten heuristischen Rahmenmodell des Bewaeltigungsprozesses als Versuche der Realitaetskonstruktion beschreiben. Ein solches Modell, in dem die individuelle Bewaeltigung in erster Linie als Prozess der Informationsverarbeitung konzeptualisiert wird, der dem Primat der Emotionsregulation und der Aufrechterhaltung der individuellen Handlungsfaehigkeit dienen soll, wird vorgestellt. [less ▲]

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See detailNote sous C. cass. Ch. Mixte, 12 avril 2002, société d'exploitation cinématographique Rex et autres c. société Cinémas Rex
Conac, Pierre-Henri UL

in Semaine Juridique. Edition Générale (La) (2002), (44), 1961-1964

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See detailModels for MIMO Propagation Channels, A Review
Yu, Kai; Ottersten, Björn UL

in Wireless Communications & Mobile Computing (2002), 2(7), 653666

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See detailThe matrix metalloproteinase 9 (mmp-9) hemopexin domain is a novel gelatin binding domain and acts as an antagonist
Roeb, E.; Schleinkofer, K.; Kernebeck, T. et al

in Journal of Biological Chemistry (2002), 277(52), 50326-32

Matrix metalloproteinases (MMPs) are involved in the remodeling processes of the extracellular matrix and the basement membrane. Most MMPs are composed of a regulatory, a catalytic, and a hemopexin ... [more ▼]

Matrix metalloproteinases (MMPs) are involved in the remodeling processes of the extracellular matrix and the basement membrane. Most MMPs are composed of a regulatory, a catalytic, and a hemopexin subunit. In many tumors the expression of MMP-9 correlates with local tumor growth, invasion, and metastasis. To analyze the role of the hemopexin domain in these processes, the MMP-9 hemopexin domain (MMP-9-PEX) was expressed as a glutathione S-transferase fusion protein in Escherichia coli. After proteolytic cleavage, the isolated PEX domain was purified by size exclusion chromatography. In a zymography assay, MMP-9-PEX was able to inhibit MMP-9 activity. The association and dissociation rates for the interaction of MMP-9-PEX with gelatin were determined by plasmon resonance. From the measured rate constants, the dissociation constant was calculated to be K(d) = 2,4 x 10(-8) m, demonstrating a high affinity between MMP-9-PEX and gelatin. In Boyden chamber experiments the recombinant MMP-9-PEX was able to inhibit the invasion of melanoma cells secreting high amounts of MMP-9 in a dose-dependent manner. These data demonstrate for the first time that the hemopexin domain of MMP-9 has a high affinity binding site for gelatin, and the particular recombinant domain is able to block MMP-9 activity and tumor cell invasion. Because MMP-9 plays an important role in metastasis, this antagonistic effect may be utilized to design MMP inhibition-based cancer therapy. [less ▲]

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See detailOestrogen action on the myocardium in vivo: specific and permissive for angiotensin-converting enzyme inhibition.
Pelzer, Theo; de Jager, Tertia; Muck, Jenny et al

in Journal of hypertension (2002), 20(5), 1001-6

OBJECTIVES: In contrast to the vasculature, it remains unclear whether oestrogens also directly affect the myocardium. In this study, we addressed basic questions regarding oestrogen effects on the ... [more ▼]

OBJECTIVES: In contrast to the vasculature, it remains unclear whether oestrogens also directly affect the myocardium. In this study, we addressed basic questions regarding oestrogen effects on the myocardium, including specificity, pathophysiological relevance and potential clinical implications, with a special focus on interactions between oestrogen and angiotensin-converting enzyme (ACE) inhibitors in an established in-vivo model of cardiac hypertrophy. METHODS AND RESULTS: Female spontaneously hypertensive rats (SHR) were ovarectomized (OVX) or sham-operated and treated with 17beta-oestradiol (2 microg/kg per day subcutaneously), the oestrogen receptor antagonist ZM-182780 (250 microg/kg per day subcutaneously) and the ACE-inhibitor moexipril (10 mg/kg per day orally) alone or in combination for 3 months. Hormone replacement restored physiological oestradiol serum levels and prevented uterus atrophy. Whereas moexipril alone was ineffective in OVX rats, substitution of oestradiol restored the beneficial effect of moexipril on systolic blood pressure (-30 +/- 5 mmHg) and relative heart weight (-11 +/- 3%) in OVX rats. Oestradiol upregulated alpha-myosin heavy chain (MHC) mRNA (+37 +/- 7%) and protein expression (+43 +/- 6%) in spite of increased blood pressure in OVX rats. Simultaneous treatment with oestradiol plus moexipril most effectively shifted the ratio of alpha-/beta-MHC mRNA and protein expression towards alpha-MHC in OVX animals. Oestradiol (10 nmol/l) also upregulated alpha-MHC mRNA and protein in cultured cardiac myocytes. The oestrogen receptor antagonist ZM-182780 significantly inhibited the observed oestrogen effects. CONCLUSIONS: Oestrogen replacement is permissive for the beneficial effects of ACE-inhibition in female SHR rats. Oestrogen effects on the myocardium in vivo are specific (i.e. oestrogen receptor mediated) because they are inhibited by a pure oestrogen receptor antagonist and occur at physiological hormone levels. [less ▲]

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See detailMontilino v. Kuhmast - Beihilfenstreit zwischen Brüssel und Berlin, Assessorklausur zum Europarecht
Cole, Mark UL; Haus, Florian C.

in Juristische Arbeitsblätter (2002)

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See detailTilt plane orientation in antiferroelectric liquid crystal cells and the origin of the pretransitional effect
Rudquist, Per; Lagerwall, Jan UL; Meier, Johann G. et al

in Physical Review. E ,Statistical, Nonlinear, and Soft Matter Physics (2002), 66(6), 061708

The optic, electro-optic, and dielectric properties of antiferroelectric liquid crystals 􏰐AFLCs􏰋 are analyzed and discussed in terms of the local tilt plane orientation. We show that the so-called ... [more ▼]

The optic, electro-optic, and dielectric properties of antiferroelectric liquid crystals 􏰐AFLCs􏰋 are analyzed and discussed in terms of the local tilt plane orientation. We show that the so-called pretransitional effect is a combination of two different electro-optic modes: the field-induced antiphase distortion of the antiferroelectric structure and the field-induced reorientation of the tilt plane. In the presence of a helix, the latter corresponds to a field-induced distortion of the helix. Both electro-optic modes are active only when the electric field has a component along the tilt plane. Thus, by assuring a horizontal surface-stabilized condition, where the helix is unwound by surface action and the tilt plane is everywhere parallel to the cell plates, the pretransitional effect should be suppressed. We also discuss the dielectrically active modes in AFLCs and under which circum- stances they contribute to the measured dielectric permittivity. [less ▲]

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See detailImplementation of the Statute of the International Criminal Court, Hungarian National Report
Ligeti, Katalin UL; Weiner, Imre A.

in Acta Juridica Hungarica (2002)

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See detailGiudizio direttissimo “atipico” e limiti temporali per l’instaurazione del rito
Allegrezza, Silvia UL

in Cassazione penale (2002), (f. 10), 3145-3151

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See detailV76D mutation in a conserved gD-crystallin region leads to dominant cataracts in mice.
Graw, Jochen; Loster, Jana; Soewarto, Dian et al

in Mammalian Genome (2002), 13(8), 452-5

During a large-scale ENU mutagenesis screen, a mouse mutant with a dominant cataract was detected and referred to as Aey4. Aim of this study was the morphological description of the mutant, the mapping of ... [more ▼]

During a large-scale ENU mutagenesis screen, a mouse mutant with a dominant cataract was detected and referred to as Aey4. Aim of this study was the morphological description of the mutant, the mapping of the mutation, and the characterization of the underlying molecular lesion. The slit-lamp examination revealed a strong nuclear cataract surrounded by a homogeneous milky opacity in the inner cortex. The histological analysis demonstrated remnants of cell nuclei throughout the entire lens. The mutation was mapped to Chromosome 1 by a genome-wide linkage making the six gamma-crystallin encoding genes and the closely linked betaA2-crystallin encoding gene to relevant candidate genes. Finally, a T-->A exchange in exon 2 of the gammaD-crystallin encoding gene (symbol: Crygd) was demonstrated to be causative for the cataract phenotype; this particular mutation is, therefore, referred to Crygo(Aey4). The alteration in codon 76 leads to an amino acid exchange of Val-->Asp. Val at this position is highly conserved; it is found in all mouse and rat gammaD/E/F-crystallins as well as in the human gammaA- and gammaD-crystallins. It may be replaced solely by Ile, which is present in all bovine gamma-crystallins, in the rat and mouse gammaA/B/C-crystallins, as well as in the human gammaB/C-crystallins. It is predicted that the exchange of a hydrophobic side chain by a polar and acidic one might influence the microenvironment by a dramatic decrease of the isoelectric point by 1.5 pH units in the 10 amino acids surrounding position 76. The Crygd(Aey4) additionally demonstrates the importance of the integrity of the Cryg gene cluster for lens transparency. [less ▲]

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See detailPhotoionization spectroscopy of traps in AlGaN/GaN HEMTs
Wolter, M.; Javorka, P.; Marso, Michel UL et al

in Journal of Electronic Materials (2002), 31(12), 1321-1324

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See detailCompte rendu: Thierry Revol: Représentation du sacré dans les textes dramatiques des XIe-XIIIe siècles en France. Paris: Champion, 1999
Cicotti, Claudio UL

in Zeitschrift für Romanische Philologie (2002), 118,(Heft 4), 744-745

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See detailA k-segments algorithm for finding principal curves
Verbeek, J. J.; Vlassis, Nikos UL; Kröse, B.

in Pattern Recognition Letters (2002), 23(8), 1009-1017

We propose an incremental method to find principal curves. Line segments are fitted and connected to form polygonal lines. New segments are inserted until a performance criterion is met. Experimental ... [more ▼]

We propose an incremental method to find principal curves. Line segments are fitted and connected to form polygonal lines. New segments are inserted until a performance criterion is met. Experimental results illustrate the performance of the method compared to other existing approaches. [less ▲]

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See detailCrustal thickness, discontinuity depth, and upper mantle structure beneath southern Africa: constraints from body wave conversions
Stankiewicz, Jacek UL; Chevrot, Sebastien; van der Hilst, Robert et al

in Physics of the Earth and Planetary Interiors (2002), 130

The technique of receiver function analysis is applied to the study of crustal and upper mantle structures beneath the Kaapvaal craton in southern Africa and its surroundings. Seismic data were recorded ... [more ▼]

The technique of receiver function analysis is applied to the study of crustal and upper mantle structures beneath the Kaapvaal craton in southern Africa and its surroundings. Seismic data were recorded by the seismic array of 82 sites deployed from April 1997 to April 1999 across southern Africa, as well as a dense array of 32 sites near Kimberley, in operation from December 1998 to June 1999. Arrival times for phases converted at the Moho are used to determine crustal thickness. The Moho depth in the south–western section of the craton was found to vary between 37 and 40 km, except for one station that recorded a depth of 43 km (SA23). Farther north along the western block of the craton (into Botswana) the depth increases up to 43 km. The depth increases even further in the north–eastern section of the craton, where results vary from 40 to 52 km. Just north of the Kaapvaal craton, in the neighbouring Zimbabwe craton, the crustal thickness drops significantly. The results obtained there varied from 36 to 40 km. For the Kimberley area, using the dense array, the Moho depth was found to be 37.3 km. Arrivals of the Ps and Ppps phases were used to determine the Poisson’s ratio in the region. This was found to be 0.26±0.01. Arrivals of phases from the 410 and 660 km mantle discontinuities are used to interpret the relative positions of these discontinuities, as well as for comparison of mantle temperatures and seismic velocities in the region with global averages. In the Kimberley area the 410 and 660 km discontinuities were found at their expected depth, implying that mantle temperatures in the region are close to the global average. The seismic velocities above the ‘410’ were found up to 5% faster than the averages from the global iasp91 model, which is fast even by Precambrian standards. In other sections of the Kaapvaal craton, the velocities are also faster than global averages, but not as fast as beneath Kimberley. In these sections, the ‘410’ is also slightly elevated, while the ‘660’ is depressed, which implies a slightly lower mantle temperature relative to the global average. Beneath the Kaapvaal craton we find evidence suggesting the presence of a zone with a reduced wavespeed gradient at an upper bound of approximately 300 km, which may mark the lower chemical boundary of the craton. [less ▲]

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See detailCalcineurin in human heart hypertrophy.
Ritter, Oliver; Hack, Susanne; Schuh, Kai et al

in Circulation (2002), 105(19), 2265-9

BACKGROUND: In animal models, increased signaling through the calcineurin pathway has been shown to be sufficient for the development of cardiac hypertrophy. Calcineurin activity has been reported to be ... [more ▼]

BACKGROUND: In animal models, increased signaling through the calcineurin pathway has been shown to be sufficient for the development of cardiac hypertrophy. Calcineurin activity has been reported to be elevated in the myocardium of patients with congestive heart failure. In contrast, few data are available about calcineurin activity in patients with pressure overload or cardiomyopathic hypertrophy who are not in cardiac failure. METHODS AND RESULTS: We investigated calcineurin activity and protein expression in 2 different forms of cardiac hypertrophy: hypertrophic obstructive cardiomyopathy (HOCM) and aortic stenosis (AS). We found that the C-terminus of calcineurin A protein containing the autoinhibitory domain was less abundant in myocardial hypertrophy than in normal heart, which suggests the possibility of proteolysis. No new splice variants could be detected by reverse-transcription polymerase chain reaction. This resulted in a significant elevation of calcineurin enzymatic activity in HOCM and AS compared with 6 normal hearts. Increased calcineurin phosphatase activity caused increased migration of NF-AT2 (nuclear factor of activated T cells 2) in SDS-PAGE compatible with pronounced NF-AT dephosphorylation in hypertrophied myocardial tissue. CONCLUSIONS: Hypertrophy in HOCM and AS without heart failure is characterized by a significant increase in calcineurin activity. This might occur by (partial) proteolysis of the calcineurin A C-terminus containing the autoinhibitory domain. Increased calcineurin activity has functional relevance, as shown by altered NF-AT phosphorylation state. Although hypertrophy in AS and HOCM may be initiated by different upstream triggers (internal versus external fiber overload), in both cases, there is activation of calcineurin, which suggests an involvement of this pathway in the pathogenesis of human cardiac hypertrophy. [less ▲]

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See detailPrävention der Posttraumatischen Belastungsstörung bei Bankangestellten nach einem Überfall
Steffgen, Georges UL; De Boer, Claudia; Bollendorff, Claude

in Arbeitsmedizin, Sozialmedizin, Umweltmedizin (2002), 37

Aim of the study: Years after being victims of a bank robbery, bank clerks still suffer from severe symptoms of post-traumatic stress. As a result of this problem, a preventive intervention program me to ... [more ▼]

Aim of the study: Years after being victims of a bank robbery, bank clerks still suffer from severe symptoms of post-traumatic stress. As a result of this problem, a preventive intervention program me to reduce post-traumatic stress was established and evaluated for the Luxembourgish financial sector. Methods and collective: The study describes the measures carried out after a hold-up. Using non-parametric data evaluation, the effects of the intervention program me were examined for the treatment group (n= 43) and compared with a control group (n= 29). Results: The symptoms of post-traumatic stress were significantly reduced in the group which received crisis intervention and stress debriefing. Conclusions: These results are the first evidence of the effectiveness of the multi-component programme. [less ▲]

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See detailTaxation and Labor Markets
Picard, Pierre M UL; Toulemonde, Eric

in Journal of Economics (2002), 78(1), 29-56

We exploit the common features of models such as union-firm wage bargaining, search and efficiency wage models to develop a framework that can be used for analyzing the effects of any budget-neutral tax ... [more ▼]

We exploit the common features of models such as union-firm wage bargaining, search and efficiency wage models to develop a framework that can be used for analyzing the effects of any budget-neutral tax reform on employment in these models. We show that taxes paid by workers are not equivalent to taxes paid by firms when taxes are non linear. Moreover, increasing progressivity is good for employment in these models. [less ▲]

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See detailSupervised dimension reduction of intrinsically low-dimensional data
Vlassis, Nikos UL; Motomura, Y.; Kröse, B.

in Neural Computation (2002), 14(1), 191-215

High-dimensional data generated by a system with limited degrees of freedom are often constrained in low-dimensional manifolds in the original space. In this article, we investigate dimension-reduction ... [more ▼]

High-dimensional data generated by a system with limited degrees of freedom are often constrained in low-dimensional manifolds in the original space. In this article, we investigate dimension-reduction methods for such intrinsically low-dimensional data through linear projections that preserve the manifold structure of the data. For intrinsically one-dimensional data, this implies projecting to a curve on the plane with as few intersections as possible. We are proposing a supervised projection pursuit method that can be regarded as an extension of the single-index model for nonparametric regression. We show results from a toy and two robotic applications. [less ▲]

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See detailFabrication and performance of AlGaN/GaN HEMTs on (111) Si substrates
Javorka, P.; Alam, A.; Marso, Michel UL et al

in Physica Status Solidi A. Applications and Materials Science (2002), 194(2), 472-475

In the current work the performance of AlGaN/GaN HEMTs fabricated on silicon substrates is presented. The AlGaN/GaN material structures were grown on (111) Si by MOVPE. Static I–V characteristics with a ... [more ▼]

In the current work the performance of AlGaN/GaN HEMTs fabricated on silicon substrates is presented. The AlGaN/GaN material structures were grown on (111) Si by MOVPE. Static I–V characteristics with a saturation current of 0.91 A/mm and a peak extrinsic transconductance of 122 mS/mm were measured and show minimal thermal effects. For devices with a gate length of 0.7 um and 0.5 um, a unity gain frequency of 20 GHz and 32 GHz and a maximum frequency of oscillation of 22 GHz and 27 GHz, respectively were obtained. The unity gain frequencies are the highest values reported so far on AlGaN/GaN/Si HEMTs and fully comparable to those known for devices using sapphire and SiC substrates. However, the fmax to fT ratio is only about 1, which indicates on parasitic conduction through the Si substrate under small signal conditions. It is shown that the saturation current and the transconductance decrease much less with increased temperature than known for similar devices grown on sapphire. [less ▲]

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See detailSurface- and field-induced AFLC structures detected by dielectric spectroscopy
Lagerwall, Jan UL; Rudquist, Per; Lagerwall, Sven T. et al

in Ferroelectrics (2002)

In order to better understand which features in dielectric spectra of antiferroelectric liquid crystals (AFLCs) are due to the bulk director geometry and which are due to surface-induced structures, we ... [more ▼]

In order to better understand which features in dielectric spectra of antiferroelectric liquid crystals (AFLCs) are due to the bulk director geometry and which are due to surface-induced structures, we have performed dielectric spectroscopy measurements with simultaneous texture monitoring on two SmC*-exhibiting AFLC homologues (11- and 12F1M7), at varying cell gap. Such AFLCs are strongly affected by surface action even in fairly thick cells (d≈15µm), with heavy supercooling of the SmC* phase as the most obvious result. We show that the supercooled structure can be removed by AC-field treatment in the SmCa* phase, but some domains may stay in a polar geometry, as reflected in both texture and dielectric signature. On heating from the antiferroelectric SmC?* subphase into SmC*, meta-stable non-helical domains may form at cell gaps much larger than the helical pitch. These domains give rise to a lowfrequency dielectric absorption not seen in bulk SmC* samples. [less ▲]

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See detailAntiferroelectric liquid crystal mixture without smectic layer shrinkage at the direct sma* - smca* transition
Giesselmann, Frank; Lagerwall, Jan UL; Andersson, G. et al

in Physical Review. E ,Statistical, Nonlinear, and Soft Matter Physics (2002), 66(5), 051704

We report results of x-ray, optic, electro-optic, and dielectric investigations on an antiferroelectric liquid- crystal mixture exhibiting a direct second-order phase transition between the Sm-A* and Sm ... [more ▼]

We report results of x-ray, optic, electro-optic, and dielectric investigations on an antiferroelectric liquid- crystal mixture exhibiting a direct second-order phase transition between the Sm-A* and Sm-Ca* phases with virtually no shrinkage in the smectic layer spacing. The birefringence measurements and texture observations suggest that the phase transition follows the diffuse cone model of Adrian de Vries, which explains the constant layer spacing. The antiferroelectric nature of the tilted phase is verified by the presence of twin polarization reversal peaks in the current response and by the absence of strong absorptions in the dielectric spectrum. The threshold for switching this phase to the synclinic, ferroelectric state is sharp and occurs at a very low voltage. [less ▲]

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See detailExtinction of particles due to unstable combustion modes
Peters, Bernhard UL

in Fuel (2002), 81

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See detail«Frontal Face and Side-Face Portraits»
Roelens, Nathalie UL

in Interdisciplinary Journal for Germanic Linguistics and Semiotic Analysis (2002)

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See detailLa future directive sur les services financiers à distance
Prüm, André UL

in Revue de Droit Bancaire et Financier (2002), (3), 111

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See detailThe new discourses on educational leadership: An introduction.
Biesta, Gert UL; Mirón, L. F.

in Studies in Philosophy & Education (2002), 21(2), 101-107

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See detailImproving Research Productivity at a Pharmaceutical Company
Ramakrishnan, S.; Caruso, A.; Schneider, Reinhard UL

in LION bioscience AG White Paper (2002)

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See detailNovel role of Janus kinase 1 in the regulation of oncostatin M receptor surface expression
Radtke, S.; Hermanns, H. M.; Haan, Claude UL et al

in Journal of Biological Chemistry (2002), 277(13), 11297-305

The oncostatin M receptor (OSMR) is part of a heterodimeric receptor complex that mediates signal transduction of the pleiotropic cytokine OSM via a signaling pathway involving Janus kinases (Jaks) and ... [more ▼]

The oncostatin M receptor (OSMR) is part of a heterodimeric receptor complex that mediates signal transduction of the pleiotropic cytokine OSM via a signaling pathway involving Janus kinases (Jaks) and transcription factors of the signal transducers and activators of transcription (STAT) family. Upon heterologous expression of the OSMR in several cell lines, we observed that its surface expression was significantly enhanced by coexpression of the Janus kinases Jak1, Jak2, and Tyk2 but not Jak3. Chimeric receptors consisting of the extracellular region of the interleukin-5 receptor beta chain and the transmembrane and intracellular part of the OSMR were similarly up-regulated on the plasma membrane when Jak1 was coexpressed. The overall expression level of these constructs did not change significantly, but Jak1 coexpression increased the amount of endoglycosidase H-resistant, fully processed OSMR chimeras. Using mutated receptor and Jak1 constructs, we were able to demonstrate that association of Jak1 with the membrane proximal region of the receptor, but not its kinase activity, is necessary for this effect. Moreover, deletion of the OSMR box1/2 region also resulted in an improved surface expression indicating that this region may contain a signal preventing efficient receptor surface expression in the absence of associated Jaks. Finally we demonstrate that in Jak1-deficient cells, the endogenous OSMR is significantly down-regulated, an effect that can be reversed by transient expression of Jak1 in these cells. [less ▲]

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See detailWetting in ternary mixtures - with and without amphiphiles
Schilling, Tanja UL; Gompper, G.

in Journal of Chemical Physics (2002), 117(15), 7284-7294

The interfacial wetting behavior of ternary fluid mixtures is investigated, both for systems where all components have isotropic interaction potentials, as well as for systems where one component is an ... [more ▼]

The interfacial wetting behavior of ternary fluid mixtures is investigated, both for systems where all components have isotropic interaction potentials, as well as for systems where one component is an amphiphile. The BEG model and the corresponding two-order-parameter Ginzburg–Landau model are employed for systems without amphiphiles. We calculate the global wetting phase diagram for nonamphiphilic mixtures. In the investigated range of interaction parameters, the wetting transitions are always continuous at three-phase coexistence. The critical behavior is found to be universal in some, nonuniversal in other parts of the phase diagram. For systems with amphiphiles, two additional interaction terms are taken into account. The first models the aggregation of amphiphilic molecules at the air–water interface, the second the formation of amphiphilic bilayers in water. We find that the first term leads to a reduction of the tension of the air–water interface, and favors wetting by the water-rich phase, while the second—bilayer—term leads to a reduction of the tension of the interface between the water-rich and amphiphile-rich phases. [less ▲]

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See detailReview of P. Verdonk. Stylistics
Weber, Jean-Jacques UL

in Style (2002), 36

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See detailCombining Beamforming with Orthogonal Space-Time Block Coding
Jöngren, George; Skoglund, Mikael; Ottersten, Björn UL

in IEEE Transactions on Information Theory (2002), 48

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See detailPanorama de jurisprudence en matière d'indemnisation du dommage mise à jour 2002.
Ravarani, Georges UL

in Pasicrisie Luxembourgeoise: Recueil Trimestriel de la Jurisprudence Luxembourgeoise (2002), 31

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See detailNociceptive sensitivity and control: hypo- and hyperalgesia under two different modes of coping
Rothermund, Klaus; Brandtstädter, Jochen; Meiniger, Claus et al

in Experimental Psychology (2002), 49(1), 57

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See detailA new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor.
Hortner, Michael; Nielsch, Ulrich; Mayr, Lorenz M. et al

in European Journal of Biochemistry (2002), 269(10), 2516-26

Erythropoietin (Epo) is a hematopoietic cytokine that is crucial for the differentiation and proliferation of erythroid progenitor cells. Epo acts on its target cells by inducing homodimerization of the ... [more ▼]

Erythropoietin (Epo) is a hematopoietic cytokine that is crucial for the differentiation and proliferation of erythroid progenitor cells. Epo acts on its target cells by inducing homodimerization of the erythropoietin receptor (EpoR), thereby triggering intracellular signaling cascades. The EpoR encompasses eight tyrosine motifs on its cytoplasmic tail that have been shown to recruit a number of regulatory proteins. Recently, the feedback inhibitor suppressor of cytokine signaling-3 (SOCS-3), also referred to as cytokine-inducible SH2-containing protein 3 (CIS-3), has been shown to act on Epo signaling by both binding to the EpoR and the EpoR-associated Janus kinase 2 (Jak2) [Sasaki, A., Yasukawa, H., Shouda, T., Kitamura, T., Dikic, I. & Yoshimura, A. (2000) J. Biol. Chem 275, 29338-29347]. In this study tyrosine 401 was identified as a binding site for SOCS-3 on the EpoR. Here we show that human SOCS-3 binds to pY401 with a Kd of 9.5 microm while another EpoR tyrosine motif, pY429pY431, can also interact with SOCS-3 but with a ninefold higher affinity than we found for the previously reported motif pY401. In addition, SOCS-3 binds the double phosphorylated motif pY429pY431 more potently than the respective singly phosphorylated tyrosines indicating a synergistic effect of these two tyrosine residues with respect to SOCS-3 binding. Surface plasmon resonance analysis, together with peptide precipitation assays and model structures of the SH2 domain of SOCS-3 complexed with EpoR peptides, provide evidence for pY429pY431 being a new high affinity binding site for SOCS-3 on the EpoR. [less ▲]

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See detailL’influence du sexe sur les variables conatives et sur la performance illustrée par l’exemple des mathématiques.
Kerger, Sylvie UL

in Psychologie différentielle : recherches et réflexions (2002)

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See detailHegel, Sellars und der Mythos des Gegebenen
Heidemann, Dietmar UL

in Hegel-Jahrbuch (2002)

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See detailMeasurement of a magnetic-field dependent correlation length in nanocrystalline Ni using small-angle neutron scattering
Michels, Andreas UL; Weissmüller, J.; Erb, U. et al

in Physica Status Solidi A. Applied Research (2002), 189

We have analyzed magnetic-field dependent small-angle neutron scattering data on nanocrystalline electrodeposited Ni by means of the correlation function of the spin misalignment. The approach yields a ... [more ▼]

We have analyzed magnetic-field dependent small-angle neutron scattering data on nanocrystalline electrodeposited Ni by means of the correlation function of the spin misalignment. The approach yields a correlation length lC of the spin misalignment that is a measure for the characteristic dimension of regions in which the magnetic moments are misaligned coherently into a common direction. We find that lC varies strongly with the applied magnetic field Hi with values extending from about 50 nm (larger than the value for uniformly magnetized grains) at small Hi to about 10 nm (considerably smaller than the grain size) at large applied fields. [less ▲]

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See detailHydrogen peroxide-mediated killing of Caenorhabditis elegans by Streptococcus pyogenes.
Jansen, W. T. M.; Bolm, M.; Balling, Rudi UL et al

in Infection and Immunity (2002), 70(9), 5202-7

Caenorhabditis elegans is currently introduced as a new, facile, and cheap model organism to study the pathogenesis of gram-negative bacteria such as Pseudomonas aeruginosa and Salmonella enterica serovar ... [more ▼]

Caenorhabditis elegans is currently introduced as a new, facile, and cheap model organism to study the pathogenesis of gram-negative bacteria such as Pseudomonas aeruginosa and Salmonella enterica serovar Typhimurium. The mechanisms of killing involve either diffusible exotoxins or infection-like processes. Recently, it was shown that also some gram-positive bacteria kill C. elegans, although the precise mechanisms of killing remained open. We examined C. elegans as a pathogenesis model for the gram-positive bacterium Streptococcus pyogenes, a major human pathogen capable of causing a wide spectrum of diseases. We demonstrate that S. pyogenes kills C. elegans, both on solid and in liquid medium. Unlike P. aeruginosa and S. enterica serovar Typhimurium, the killing by S. pyogenes is solely mediated by hydrogen peroxide. Killing required live streptococci; the killing capacity depends on the amount of hydrogen peroxide produced, and killing can be inhibited by catalase. Major exotoxins of S. pyogenes are not involved in the killing process as confirmed by using specific toxin inhibitors and knockout mutants. Moreover, no accumulation of S. pyogenes in C. elegans is observed, which excludes the involvement of infection-like processes. Preliminary results show that S. pneumoniae can also kill C. elegans by hydrogen peroxide production. Hydrogen peroxide-mediated killing might represent a common mechanism by which gram-positive, catalase-negative pathogens kill C. elegans. [less ▲]

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See detailShipping news. The implications of electronic commerce for logistics and freight transportation.
Hesse, Markus UL

in Resources, Conservation and Recycling (2002), 36(3), 211-240

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See detailFamiliale Vererbung von Dominanzideologien in verschiedenen sozio-ökonomischen Kontexten
Hadjar, Andreas UL; Baier, Dirk

in Zeitschrift für Politische Psychologie (2002), 10

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See detailVergleichsprozesse in der Auseinandersetzung mit schweren körperlichen Erkrankungen.
Filip, Sigrun-Heide; Ferring, Dieter UL

in Psychotherapie im Dialog (2002), 3(1)

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See detailThe philosophy of educational leadership: Emerging themes and emerging perspectives.
Mirón,L.F.; Biesta, Gert UL

in Studies in Philosophy & Education (2002), 21(2), 101-102

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See detailGrundfälle zum Europarecht - 1. und 2. Teil (Einleitung und Grundlagen)
Cole, Mark UL; Haus, Florian C.

in Juristische Schulung : Zeitschrift für Studium und Referendariat (2002)

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See detailReformpädagogik vor Rousseau
Tröhler, Daniel UL

in Zeitschrift für Pädagogische Historiographie (2002), 8(1), 16-19

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See detailHuman centered processes and decision support systems
Barthélemy, J. P.; Bisdorff, Raymond UL; Coppin, G.

in European Journal of Operational Research (2002), 136(2), 233-252

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See detailSoziale Vergleiche zwischen Geschwistern im frühen Erwachsenenalter: Eine explorative Studie
Ferring, Dieter UL; Boll, Thomas UL; Neumann, B.

in Zeitschrift für Entwicklungspsychologie und Padagogische Psychologie (2002), 34(3), 174-193

The present study focuses on social comparisons in sibling relations in early adulthood. Starting from theoretical and empirical evidence of social comparison theory as well as research and findings on ... [more ▼]

The present study focuses on social comparisons in sibling relations in early adulthood. Starting from theoretical and empirical evidence of social comparison theory as well as research and findings on sibling relations, the thesis of a self-serving use of social comparisons in sibling relations is elaborated. A sample of N = 100 subjects had to name up to ten positive and ten negative personal characteristics which were additionally rated with respect to their personal importance; resulting comparison judgments were analyzed with respect to inferred similarity and/or inferiority as well as superiority towards the sibling. Furthermore, relations between comparison judgments and structural variables of sibling relations (i.e., sex of siblings) as well as self-esteem were explored; the effects of social comparison on indicators of relationship quality were investigated in the final step of the analysis. Findings showed that subjects formulated more dissimilarity than similarity in their judgments. Personal characteristics from which subjects inferred inferiority towards the sibling were rated as significantly less important than characteristics from which superiority was inferred. Furthermore, social comparisons were weakly related to structural characteristics and self-esteem but showed a more substantial and differential association with indicators of relationship quality. [less ▲]

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See detailRespiratory mechanics in mice: strain and sex specific differences.
Schulz, H.; Johner, C.; Eder, G. et al

in Acta Physiologica Scandinavica (2002), 174(4), 367-75

To assess the contribution of genetic background to respiratory mechanics, we developed a ventilator unit to measure lung function parameters in the mouse. We studied two commonly used inbred mice strains ... [more ▼]

To assess the contribution of genetic background to respiratory mechanics, we developed a ventilator unit to measure lung function parameters in the mouse. We studied two commonly used inbred mice strains originating from Mus musculus domesticus (C57BL/6 and C3HeB/FeJ) and a third strain derived from Mus musculus molossinus [Japanese fancy mouse 1 (JF1)]. The ventilator allows for accurate performance of the different breathing manoeuvres required for measuring in- and expiratory reserve capacity, quasi-static and dynamic compliance, and airway resistance. In combination with a mass spectrometer for monitoring gas concentrations, single-breath manoeuvres were performed and He-expirograms obtained, from which dead space volume and slope of phase III were determined. From each strain and each sex, 10, 2-month old animals were studied immediately after being killed by an intraperitoneal overdose of xylazine and ketamine. C3HeB/FeJ and C57BL/6 exhibited comparable lung volumes. In male C3HeB/FeJ mice, e.g. vital capacity (VC) was 1072 +/- 79 microL, inspiratory reserve capacity 782 +/- 88 microL, and dead space volume at total lung inflation 216 +/- 18 microL. Lung volumes of JF1 were significantly lower (e.g. VC 611 +/- 53 microL, P < 0.01) even when normalized to body weight. In all three strains, specific lung volumes were significantly higher in females than in males, possibly explained by a higher oxygen demand during pregnancy and lactation, both of which fill most of their life times. Static compliance in C3HeB/FeJ was 64.3 +/- 5.4 microL cmH2O-1. It was smaller in C57BL/6 and JF1 mice, even when related to the lung volume. Analysis of the degree of genetic vs. non-genetic components of the phenotypic variation revealed that at least 80% of the total variation of lung volumes and static compliance in the mixed population is attributable to genetic differences between individuals. These differences will be verified in further studies by segregation and genetic linkage analysis. [less ▲]

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See detailKulturelle Vielfalt in transnationalen Kooperationen und Projekten verstehen und nutzen
Molz, Markus UL; Vollmer, Thomas

in Forum Jugendhilfe (2002), 4

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See detail14-3-3 protein is a component of Lewy bodies in Parkinson's disease-mutation analysis and association studies of 14-3-3 eta.
Ubl, Andreas; Berg, Daniela; Holzmann, Carsten et al

in Molecular Brain Research (2002), 108(1-2), 33-9

Mutations in alpha-synuclein have been identified in some rare families with autosomal dominant Parkinson's disease (PD). The synuclein gene family shares physical and functional homology with 14-3-3 ... [more ▼]

Mutations in alpha-synuclein have been identified in some rare families with autosomal dominant Parkinson's disease (PD). The synuclein gene family shares physical and functional homology with 14-3-3 proteins and binds to 14-3-3 proteins and to its ligands. We therefore investigated whether 14-3-3 proteins are also involved in the pathogenesis of PD. Here we demonstrate that 14-3-3 proteins are colocalized with Lewy bodies in PD. We investigated the 14-3-3 eta (YWHAH) gene by mutation analysis and association studies as it maps to human chromosome 22q12.1-q13.1, a region which has been recently implicated in PD and carried out immunohistochemical studies of Lewy bodies with two different 14-3-3 eta antibodies. In 358 sporadic and familial PD patients, disease causing mutations were not identified. Furthermore, association studies with intragenic polymorphisms do not provide evidence for an involvement of 14-3-3 eta in the pathogenesis of PD. In accordance with these findings, there was no staining of substantia nigra Lewy bodies with antibodies specific for the 14-3-3 eta subunit. [less ▲]

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See detailA greedy EM algorithm for Gaussian mixture learning
Vlassis, Nikos UL; Likas, A.

in Neural Processing Letters (2002), 15(1), 77-87

Learning a Gaussian mixture with a local algorithm like EM can be difficult because (i) the true number of mixing components is usually unknown, (ii) there is no generally accepted method for parameter ... [more ▼]

Learning a Gaussian mixture with a local algorithm like EM can be difficult because (i) the true number of mixing components is usually unknown, (ii) there is no generally accepted method for parameter initialization, and (iii) the algorithm can get trapped in one of the many local maxima of the likelihood function. In this paper we propose a greedy algorithm for learning a Gaussian mixture which tries to overcome these limitations. In particular, starting with a single component and adding components sequentially until a maximum number k, the algorithm is capable of achieving solutions superior to EM with k components in terms of the likelihood of a test set. The algorithm is based on recent theoretical results on incremental mixture density estimation, and uses a combination of global and local search each time a new component is added to the mixture. [less ▲]

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See detailParis, 25 octobre 2001
Cuniberti, Gilles UL

in Clunet (2002)

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See detailPhases, phase transitions and confinement effects in a series of antiferroelectric liquid crystals
Lagerwall, Jan UL; Parghi, Deven D.; Krüerke, Daniel et al

in Liquid Crystals (2002), 29(2), 163-178

Using a variety of optical and electrooptical techniques as well as dielectric spectroscopy, we have investigated three homologues in the chiral liquid crystal series nF1M7, where n denotes the length of ... [more ▼]

Using a variety of optical and electrooptical techniques as well as dielectric spectroscopy, we have investigated three homologues in the chiral liquid crystal series nF1M7, where n denotes the length of the unbranched side-chain. The main focus of the study is the series of smectic C subphases, i.e. SmCa*, SmC1/3* and SmC1/4*. During switching in the SmCa* phase, a peculiar redirection of the plane of biaxiality, distinguishing this phase from SmA* and SmC*, was observed. We present a simple explanation for this behaviour which correlates well with the clock model description of the SmCa* phase. We found a zero mesoscopic polarisation for the SmC1/4* phase and a non-zero mesoscopic polarisation for SmC1/3*, observations which are consistent with a distorted clock model. The dielectric spectroscopy investigations, performed at several different cell gaps, clearly show that the dielectric response in these materials is easily dominated by surface-induced structures if the cell gap is reduced, and thus reflects the bulk thermodynamic phase in very thick cells only. [less ▲]

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See detailCity Logistics. Network Modelling and Intelligent Transport Systems
Hesse, Markus UL

in Journal of Transport Geography (2002), 10

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See detailKrieg und militärische Akkulturation
Kolnberger, Thomas UL

in Historische Sozialkunde: Geschichte - Fachdidaktik - Politische Bildung (2002), 4

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See detailSpectrum of phenotypes and genotypes in Parkinson's disease.
Riess, Olaf; Krüger, Rejko UL; Schulz, Jorg B.

in Journal of neurology (2002), 249 Suppl 3

The pathogenesis of Parkinsons disease (PD) is currently unknown. Environmental and genetic factors might contribute to the neurodegenerative process. Genetic mapping approaches in rare familial cases ... [more ▼]

The pathogenesis of Parkinsons disease (PD) is currently unknown. Environmental and genetic factors might contribute to the neurodegenerative process. Genetic mapping approaches in rare familial cases with autosomal recessive and autosomal dominant inheritance of PD suggest wide genetic heterogeneity of the disease. These gene loci in turn allow now a more specific clinical investigation of affected families to study the clinical heterogeneity of PD. The recent identification of mutations in three genes involved in protein degradation and aggregation in familial PD does now facilitate the deciphering of other genes involved in the pathogenesis of the disease. [less ▲]

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See detailDetermination of channel temperature in AlGaN/GaN HEMTs grown on sapphire and silicon substrates using DC characterization method
Kuzmík, J.; Javorka, P.; Alam, A. et al

in IEEE Transactions on Electron Devices (2002), 49(8), 1496-1498

Self-heating effects and temperature rise in AlGaN/GaN HEMTs grown on silicon and sapphire substrates are studied, exploiting transistor dc characterization methods. A negative differential output ... [more ▼]

Self-heating effects and temperature rise in AlGaN/GaN HEMTs grown on silicon and sapphire substrates are studied, exploiting transistor dc characterization methods. A negative differential output resistance is observed for high dissipated power levels. An analytical formula for a source-drain current drop as a function of parasitic source resistance and threshold voltage changes is proposed to explain this behavior. The transistor source resistance and threshold voltage is determined experimentally at different elevated temperatures to construct channel temperature versus dissipated power transfer characteristic. It is found that the HEMT channel temperature increases rapidly with dissipated power and at 6 W/mm reaches values of 320 C for sapphire and 95 C for silicon substrate, respectively. [less ▲]

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See detailElectre-like clustering from a pairwise fuzzy proximity index
Bisdorff, Raymond UL

in European Journal of Operational Research (2002), 138(2), 320-331

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See detailConnection between type B (or C) and F factorizations and construction of algebras
del Sol Mesa, Antonio UL

in Journal of Physics: A Mathematical and General (2002)

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See detailA molecular mechanism improving the contractile state in human myocardial hypertrophy.
Ritter, Oliver; Bottez, Nico; Burkard, Natalie et al

in Experimental and Clinical Cardiology (2002), 7(2-3), 151-7

BACKGROUND: Various molecular mechanisms are operative in altering the sarcomeric function of the heart under increased hemodynamic workload. Expression of the atrial isoform (ALC-1) of the essential ... [more ▼]

BACKGROUND: Various molecular mechanisms are operative in altering the sarcomeric function of the heart under increased hemodynamic workload. Expression of the atrial isoform (ALC-1) of the essential myosin light chain, a shift from alpha-myosin heavy chain (MHC) to beta-MHC, increased phosphorylation of the regulatory myosin light chains and increased troponin I (TnI) phosphorylation have been reported to modulate cardiac contractility in rodents. METHODS: TO ASSESS A POSSIBLE CONTRIBUTION OF THESE SARCOMERIC PROTEINS TO CARDIAC PERFORMANCE IN HUMAN MYOCARDIAL HYPERTROPHY, TWO DIFFERENT FORMS OF CARDIAC HYPERTROPHY WERE INVESTIGATED: 19 patients with hypertropic obstructive cardiomyopathy (HOCM) and 13 patients with aortic stenosis (AS) with marked left ventricular hypertrophy and normal systolic function. RESULTS: There was no change in MHC gene expression, regulatory myosin light chain or TnI phosphorylation status in normal heart (NH), HOCM and AS patients. However, patients with hypertrophied myocardium expressed ALC-1 that was not detectable in NH. ALC-1 protein expression correlated positively with the left ventricular ejection fraction. In patients with hypertrophied myocardium, there was a mean ALC-1 protein expression of 12.7+/-3% (range 3.6% to 32%). CONCLUSION: In humans, ALC-1 expression is in vivo a powerful molecular mechanism of the sarcomere to maintain or improve myocardial contractility under increased hemodynamic demands. [less ▲]

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See detailAschkenasisch-Romanisch im 18. Jahrhundert.
Schumacher, Jutta UL

in Jiddistik-Mitteilungen (2002), 28

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See detailVirtual Selves and Web Surveys
Manfreda, Katja; Couper, Mick; Vohar, Mateja et al

in Metodološki zvezki (2002), 18

With rapid transfer of many forms of social inquiry through structured questionnaires to the Web it is increasingly important to explore whether the Web is indeed a ‘socially neutral’ research tool as ... [more ▼]

With rapid transfer of many forms of social inquiry through structured questionnaires to the Web it is increasingly important to explore whether the Web is indeed a ‘socially neutral’ research tool as many believe. Because of the graphical and interactive nature of the Web and the context of global environment, social desirability effects in Web surveys may be different from with other self-administered methods, which usually reduce them. In addition, increased use of interactive services, such as multiple user domains, interactive chat rooms and interactive online games encourages widespread adoption of ‘virtual personas’ on the Web. It is thus important to explore how participation in such interactive services may mitigate potential benefits of the Web for social research. Our research explores whether those who are frequent participants in so-called ‘alternate realities’ on the Web are more likely to present their ‘virtual personas’ or their ‘real selves’ when answering questions in Web surveys. Users of interactive services are identified in a large national Web survey of Internet users in Slovenia within the project RIS (http://www.ris.org) at the Faculty of Social Sciences, University of Ljubljana. They are asked a variety of questions relating to self-image that are known to be subject to social desirability bias. At the end of the survey they are asked for their telephone number. A random sample of respondents from the population of non-users of interactive services is also selected. Both groups are then administered a telephone survey, with the key self-presentation and social desirability items replicated. We then compare the responses to the telephone survey with those provided in the Web survey. Our hypothesis is that those who are regular participants in interactive services are more likely to present themselves in a different light on the Web than on the telephone, relative to the non-user group. [less ▲]

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See detailParkinson's disease: one biochemical pathway to fit all genes?
Krüger, Rejko UL; Eberhardt, Olaf; Riess, Olaf et al

in Trends in molecular medicine (2002), 8(5), 236-40

Although originally discounted, hereditary factors have emerged as the focus of research in Parkinson's disease (PD). Genetic studies have identified mutations in alpha-synuclein and ubiquitin C-terminal ... [more ▼]

Although originally discounted, hereditary factors have emerged as the focus of research in Parkinson's disease (PD). Genetic studies have identified mutations in alpha-synuclein and ubiquitin C-terminal hydrolase as rare causes of autosomal dominant PD and mutations in parkin as a cause of autosomal recessive PD. Functional characterization of the identified disease genes implicates the ubiquitin-mediated protein degradation pathway in these hereditary forms of PD and also in the more common sporadic forms of PD. Subsequent identification of further loci in familial PD and diverse genetic factors modulating the risk for sporadic PD point to substantial genetic heterogeneity in the disease. Thus, new candidate genes are expected to encode proteins either involved in ubiquitin-mediated protein degradation or sequestrated in intracytoplasmic protein aggregations. Future identification of disease genes is required to confirm this hypothesis, thereby unifying the clinical and genetic heterogeneity of PD, including the common sporadic form of the disease, by one biochemical pathway. [less ▲]

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See detailStructured Semi-Blind Interference Rejection in Dispersive Multichannel Systems
Klang, Göran; Ottersten, Björn UL

in IEEE Transactions on Signal Processing (2002), 50(8), 20272036

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See detailSub art. 213-217
Allegrezza, Silvia UL

in Codice di procedura penale commentato (2002)

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See detailInvestigation of AlGaN/GaN HEMTs on Si substrate using backgating
Marso, Michel UL; Wolter, M.; Javorka, P. et al

in Physica Status Solidi C. Current Topics in Solid State Physics (2002), (1), 65-68

The influence of a substrate voltage on the dc characteristics of an AlGaN/GaN HEMT on silicon (111) substrate is investigated. This effect, known as backgating, is used to study traps that are located ... [more ▼]

The influence of a substrate voltage on the dc characteristics of an AlGaN/GaN HEMT on silicon (111) substrate is investigated. This effect, known as backgating, is used to study traps that are located between substrate and 2DEG channel. The transient of the drain current after applying a negative substrate voltage is evaluated for measurements with and without illumination. Several trap contributions are resolved by measurements at different photon energies. A photocurrent is observed up to 600 nm wavelength. Up to this wavelength the backgating effect can be compensated and the drain current restored by a short light pulse. The experiments are performed on completed HEMTs, allowing investigation of the influence of device fabrication technology. [less ▲]

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See detailDisability and quality of life in spina bifida and hydrocephalus
Pit-Ten Cate, Ineke UL; Kennedy, Collin; Stevenson, Jim

in Developmental Medicine and Child Neurology. Supplement (2002), 44(5), 317-322

This study examined the impact of severity and type of condition and family resources on quality of life in children with spina bifida and hydrocephalus. A national UK sample of children aged between 6 ... [more ▼]

This study examined the impact of severity and type of condition and family resources on quality of life in children with spina bifida and hydrocephalus. A national UK sample of children aged between 6 and 13 years with spina bifida (n=62), hydrocephalus (n=354), and spina bifida plus hydrocephalus (n=128) were identified via the register of the Association for Spina Bifida and Hydrocephalus (ASBAH). Parents completed standardized measures of Child Health Related Quality Of Life (CQOL), family needs survey (FNS), and caregiving self-efficacy scale (CSES) as well as questions on children's health and physical ability. Results showed there were no significant differences in the overall quality of life for the three disability conditions. The overall CQOL was over 1 SD lower for those with spina bifida and hydrocephalus than for children with other physical conditions. Sex and age were not related to overall CQOL. Specific aspects of CQOL differentiated the three groups. Children with spina. bifida had poorer CQOL scores on self-care, continence, and mobility/activities whilst those with hydrocephalus had poorer scores on school activities, worries, sight, and communication. Severity of condition and family resources, i.e. CSES and FNS, predicted 32% of the variance in CQOL. Associations were also found between overall CQOL and problems discernible at birth as well as epilepsy. Other factors, including those related to shunts, were not significantly related to CQOL. It was concluded that hydrocephalus is just as great a threat to CQOL as spina bifida. Beyond the general effect of condition severity on CQOL, family resources (as measured by the CSES and FNS) represent an additional influence on CQOL. [less ▲]

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See detailPlädoyer für die Förderung eigenverantworteter Spiritualität unter Christen
Weber, Jean-Marie UL

in Forum für Politik, Gesellschaft und Kultur in Luxemburg (2002)

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See detailBildung and modernity. The future of Bildung in a world of difference.
Biesta, Gert UL

in Studies in Philosophy & Education (2002), 21(4/5), 343-351

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See detailDas Ruhrgebiet als Lagerhalle. Logport oder vom Versuch, die moderne Warenwirtschaft zu zähmen.
Hesse, Markus UL

in RaumPlanung (2002), (104), 236-240

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See detailEvaluation of the precision of using absolute gravimeters to calibrate superconducting gravimeters
Francis, Olivier UL; van Dam, Tonie UL

in Metrologia (2002), 39(5), 485-488

We present an experiment in which four different FG5 absolute gravimeters (AG) were operated simultaneously alongside a superconducting relative gravimeter (SG). We demonstrate that 0.1 % precision can be ... [more ▼]

We present an experiment in which four different FG5 absolute gravimeters (AG) were operated simultaneously alongside a superconducting relative gravimeter (SG). We demonstrate that 0.1 % precision can be achieved on the calibration factor of the SG by comparison with AG measurements, independently of the FG5 instrument used for the calibration and of the offsets among the FG5 absolute values. This experiment demonstrates the robustness of using any FG5 absolute gravimeter to calibrate any SG. This result is of value to geoscientists analysing data from (a) globally distributed SGs which most probably have been calibrated using different instruments; or (b) any individual SG calibrated with different FG5 absolute gravimeters. [less ▲]

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See detailInstruction or pedagogy? The need for a transformative conception of education.
Biesta, Gert UL; Miedema, S.

in Teaching & Teacher Education (2002), 18

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See detailThe balance model : Hindrance or support for the solving of linear equations with one unknown
Vlassis, Joëlle UL

in Educational Studies in Mathematics (2002)

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See detailHexenprozesse im Herzogtum Luxemburg: Echternach 1679/1680
Kmec, Sonja UL

in Hemecht : Zeitschrift für Luxemburger Geschichte = Revue d'Histoire Luxembourgeoise (2002), 54

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See detailHPA-1a phenotype-genotype discrepancy reveals a naturally occurring Arg93Gln substitution in the platelet beta 3 integrin that disrupts the HPA-1a epitope.
Watkins, Nicholas A.; Schaffner-Reckinger, Elisabeth UL; Allen, David L. et al

in Blood (2002), 99(5), 1833-9

A single nucleotide polymorphism (SNP) at position 196 in the beta 3 integrin causes a Leu33Pro substitution in the mature protein. Alloimmunization against the beta 3Leu33 form (human platelet antigen ... [more ▼]

A single nucleotide polymorphism (SNP) at position 196 in the beta 3 integrin causes a Leu33Pro substitution in the mature protein. Alloimmunization against the beta 3Leu33 form (human platelet antigen [HPA]-1a, Pl(A1), Zw(a)) in patients who are beta 3Pro33 homozygous (HPA-1b1b, Pl(A2A2), Zw(bb)) causes neonatal alloimmune thrombocytopenia, posttransfusion purpura, or refractoriness to platelet transfusion. Studies with recombinant proteins have demonstrated that amino acids 1 to 66 and 288 to 490 of the beta 3 integrin contribute to HPA-1a epitope formation. In determining the HPA-1a status of more than 6000 donors, we identified a donor with an HPA-1a(weak) phenotype and an HPA-1a1b genotype. The platelets from this donor had normal levels of surface alpha IIb beta 3 but reacted only weakly with monoclonal and polyclonal anti-HPA-1a by whole blood enzyme-linked immunosorbent assay (ELISA), flow cytometry, and sandwich ELISA. We reasoned that an alteration in the primary nucleotide sequence of the beta 3Leu33 allele of this donor was disrupting the HPA-1a epitope. In agreement with this hypothesis, sequencing platelet RNA-derived alpha IIb and beta 3 cDNA identified a novel G/A SNP at position 376 of the beta 3 integrin that encodes for an Arg93Gln replacement in the beta 3Leu33 allele. Coexpression of the beta 3Leu33Gln93 encoding cDNA in Chinese hamster ovary cells with human alpha IIb cDNA showed that the surface-expressed alpha IIb beta 3 reacted normally with beta 3 integrin-specific monoclonal antibodies but only weakly with monoclonal anti-HPA-1a. Our results show that an Arg93Gln mutation in the beta 3Leu33 encoding allele disrupts the HPA-1a epitope, suggesting that Arg93 contributes to the formation of the HPA-1a B-cell epitope. [less ▲]

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See detailExcluding Children from Refugee Status: Child Soldiers and Article 1F of the Refugee Convention’
Happold, Matthew UL

in American University International Law Review (2002), 17

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See detailComment on "Nature of the recent vertical ground movements inferred from high-precision leveling data in an intraplate setting: NE Ardenne, Belgium" by A. Demoulin and A. Collignon
Camelbeeck, Thierry; Van Camp, Michel; Jongmans, Denis et al

in Journal of Geophysical Research (2002), 107(B11), 2281-2281

Comment on ‘‘Nature of the recent vertical ground movements inferred from high-precision leveling data in an intraplate setting: NE Ardenne, Belgium’’ by A. Demoulin and A. Collignon

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See detailProgressive loss of PAX9 expression correlates with increasing malignancy of dysplastic and cancerous epithelium of the human oesophagus.
Gerber, Josef-Karl; Richter, Thomas; Kremmer, Elisabeth et al

in Journal of Pathology (2002), 197(3), 293-7

Pax genes encode a family of transcription factors that play key roles in embryonic development. Whereas the functions of Pax genes in the adult organism are largely unknown, upregulated Pax gene ... [more ▼]

Pax genes encode a family of transcription factors that play key roles in embryonic development. Whereas the functions of Pax genes in the adult organism are largely unknown, upregulated Pax gene expression has been implicated in tumourigenesis. In this study, PAX9-specific monoclonal antibodies have been generated and it has been shown that PAX9 protein is expressed in the normal epithelium of the adult human oesophagus. PAX9 expression was either lost or significantly reduced in the majority of invasive carcinomas and epithelial dysplasias, the latter representing precancerous lesions. Notably, the percentage of PAX9-positive cells within the epithelium decreased with increasing malignancy of the epithelial lesion. These results identify PAX9 as a sensitive marker for deregulated differentiation of oesophageal keratinocytes and indicate a role for PAX9 in the normal differentiation process of internal stratified squamous epithelia. These data suggest that upregulated PAX9 expression is not required for the formation of the majority of squamous cell carcinomas of the human oesophagus. [less ▲]

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See detailL’industrie électrique dans l’économie européenne, 1860-1914
Leboutte, René UL

in Bulletin Scientifique de l'Association des Ingénieurs Electriciens sortis de l'Institut Electrotechnique Montefiore (2002), 115

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See detailJ'accuse, oder die Wahrheit über den Sprachenunterricht in Luxemburg
Weber, Jean-Jacques UL; Horner, Kristine

in Praxis des Neusprachlichen Unterrichts (2002), 49

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See detailDécision de la Cour de cassation, 1ère Civ., 26 juin & 16 oct. 2001
Cuniberti, Gilles UL; Kaplan, Charles

in Juris-Classeur périodique (2002)

Étendue du principe compétence-compétence.

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See detailA probabilistic approach to the Yang-Mills heat equation
Arnaudon, Marc; Bauer, Robert O.; Thalmaier, Anton UL

in Journal de Mathématiques Pures et Appliquées (2002), 81(2), 143-166

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See detailPromoter characterization and genomic organization of the gene encoding integrin-linked kinase 1
Melchior, C. A; Kreis, Stephanie UL; Janji, B. B et al

in Biochimica et Biophysica Acta-Gene Structure and Expression (2002), 1575(1-3), 117-122

Integrin-linked kinase (ILK)-1 is a 59-kDa serine-threonine protein kinase, which associates with the cytoplasmic domain of β1, β2 and β3 integrins and acts as a receptor proximal kinase regulating ... [more ▼]

Integrin-linked kinase (ILK)-1 is a 59-kDa serine-threonine protein kinase, which associates with the cytoplasmic domain of β1, β2 and β3 integrins and acts as a receptor proximal kinase regulating integrin-mediated signal transduction. We have recently identified an isoform of ILK (ILK-2), which is expressed, in a TGF-β1-dependent manner, in a highly invasive tumor cell line but not in normal adult tissues. In contrast, ILK-1 is ubiquitously expressed in normal tissues and is up-regulated in various tumors independent of TGF-β1. Here, we report the structural organization and the promoter activity of the human ILK-1 gene, contained within a 8.8-kb genomic fragment cloned from a human BAC library. The mature protein is encoded by 13 exons. The last coding exon contains the entire 3′ UTR of the ILK-1 gene, which overlaps with the complementary 3′ UTR sequence of the TAF2H gene, a TATA box binding protein-associated factor. A major transcriptional initiation start site was found 138 bp upstream of exon 1 in close proximity to a consensus initiator element (Inr). The ILK gene is transcribed by a TATA-less and CAAT-less promoter with typical features of housekeeping genes. The promoter activity was characterized by a luciferase reporter assay and the minimal sequence conferring promoter activity was 349 bp in size and located immediately upstream of exon 1. © 2002 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailTrade Union Objectives and Economic Growth
Irmen, Andreas UL; Wigger, Berthold U.

in FinanzArchiv: Public Finance Analysis (2002), 59(1), 49-

A trade union whose purpose is to raise wages above the competitive level may foster economic growth if it succeeds in shifting income away from the owners of capital to the workers and if the workers ... [more ▼]

A trade union whose purpose is to raise wages above the competitive level may foster economic growth if it succeeds in shifting income away from the owners of capital to the workers and if the workers' marginal propensity to save exceeds the one of capitalists. We make this point in an overlapping generations framework with unionized labor. Considering a monopoly union which cares for wages and employment, we determine a range of trade union objectives and characterize the aggregate technology so that the union's policy spurs per capita income growth. However, the union's policy cannot lead to a Pareto-improvement. [less ▲]

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See detailCross-border production systems and cross-border corporate cultures? The case of the Saar-Lorraine automotive industry.
Dörrenbächer, Peter UL; Schulz, Christian UL

in Erde: Zeitschrift der Gesellschaft für Erdkunde zu Berlin (2002), 133(1), 3-17

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See detailPolymorphisms in the interleukin-1 alpha and beta genes and the risk for Parkinson's disease.
Schulte, Thorsten; Schols, Ludger; Muller, Thomas et al

in Neuroscience Letters (2002), 326(1), 70-2

Several lines of evidence indicate that immune mechanisms are involved in the pathogenesis of neurodegenerative disorders. Activated immunocompetent cells and inflammatory cytokines are present in ... [more ▼]

Several lines of evidence indicate that immune mechanisms are involved in the pathogenesis of neurodegenerative disorders. Activated immunocompetent cells and inflammatory cytokines are present in affected brain regions in patients with Alzheimer's (AD) and Parkinson's disease (PD). For AD biochemical and pathological data are supported by genetic studies identifying risk alleles for polymorphisms in regulatory regions of the interleukin-1 alpha (IL-1 alpha-889) and interleukin-1 beta (IL-1 beta-511) gene, respectively. The partially overlapping pathology and inflammatory reaction pattern between AD and PD led us to investigate these polymorphisms in a large sample of 295 German PD patients and 270 healthy controls. We found T in position -511 in the IL-1 beta gene more frequent in patients compared to controls (chi(2)=4.44, P=0.034). For the IL-1 alpha-889 polymorphism no significant difference between patients and controls was observed. [less ▲]

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See detailNeurofilament L gene is not a genetic factor of sporadic and familial Parkinson's disease.
Rahner, Nils; Holzmann, Carsten; Krüger, Rejko UL et al

in Brain research (2002), 951(1), 82-6

Mutations in two genes, alpha-synuclein and parkin, have been identified as some rare causes for familial Parkinson's disease (PD). alpha-Synuclein and parkin protein have subsequently been identified in ... [more ▼]

Mutations in two genes, alpha-synuclein and parkin, have been identified as some rare causes for familial Parkinson's disease (PD). alpha-Synuclein and parkin protein have subsequently been identified in Lewy bodies (LB). To gain further insight into the pathogenesis of PD we investigated the role of neurofilament light (NF-L), another component of LB aggregation. A detailed mutation search of the NF-L gene in 328 sporadic and familial PD patients of German ancestry revealed three silent DNA changes (G163A, C224T, C487T) in three unrelated patients. Analysis of the promoter region of the NF-L gene identified a total of three base pair substitutions defining five haplotypes. Association studies based on these haplotypes revealed no significant differences between PD patients and 344 control individuals. Therefore, NF-L is unlikely to play a major role in the pathogenesis of PD. [less ▲]

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See detailHow does the brain discriminate familiar and unfamiliar faces? A pet study of face categorical perception
Rossion, Bruno; Schiltz, Christine UL; Robaye, Laurence et al

in Journal of Cognitive Neuroscience (2001), 13(7), 1019-1034

Where and how does the brain discriminate familiar and unfamiliar faces? This question has not been answered yet by neuroimaging studies partly because different tasks were performed on familiar and ... [more ▼]

Where and how does the brain discriminate familiar and unfamiliar faces? This question has not been answered yet by neuroimaging studies partly because different tasks were performed on familiar and unfamiliar faces, or because familiar faces were associated with semantic and lexical information. Here eight subjects were trained during 3 days with a set of 30 faces. The familiarized faces were morphed with unfamiliar faces. Presented with continua of unfamiliar and familiar faces in a pilot experiment, a group of eight subjects presented a categorical perception of face familiarity: there was a sharp boundary in percentage of familiarity decisions between 40% and 60% faces. In the main experiment, subjects were scanned (PET) on the fourth day (after 3 days of training) in six conditions, all requiring a sex classification task. Completely novel faces (0%) were presented in Condition 1 and familiar faces (100%) in Condition 6, while faces of steps of 20% in the continuum of familiarity were presented in Conditions 2 to 5 (20% to 80%). A principal component analysis (PCA) indicated that most variations in neural responses were related to the dissociation between faces perceived as familiar (60% to 100%) and faces perceived as unfamiliar (0 to 40%). Subtraction analyses did not disclose any increase of activation for faces perceived as familiar while there were large relative increases for faces perceived as unfamiliar in several regions of the right occipito-temporal visual pathway. These changes were all categorical and were observed mainly in the right middle occipital gyrus, the right posterior fusiform gyrus, and the right inferotemporal cortex. These results show that (1) the discrimination between familiar and unfamiliar faces is related to relative increases in the right ventral pathway to unfamiliar/novel faces; (2) familiar and unfamiliar faces are discriminated in an all-or-none fashion rather than proportionally to their resemblance to stored representations; and (3) categorical perception of faces is associated with abrupt changes of brain activity in the regions that discriminate the two extremes of the multidimensional continuum. [less ▲]

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See detailThe use of the discrete Sugeno integral in decision making: a survey
Dubois, Didier; Marichal, Jean-Luc UL; Prade, Henri et al

in International Journal of Uncertainty, Fuzziness and Knowledge-Based Systems (2001), 9(5), 539-561

An overview of the use of the discrete Sugeno integral as either an aggregation tool or a preference functional is presented in the qualitative framework of two decision paradigms: multi-criteria decision ... [more ▼]

An overview of the use of the discrete Sugeno integral as either an aggregation tool or a preference functional is presented in the qualitative framework of two decision paradigms: multi-criteria decision-making and decision-making under uncertainty. The parallelism between the representation theorems in both settings is stressed, even if a basic requirement like the idempotency of the aggregation scheme should be explicitely stated in multi-criteria decision-making, while its counterpart is implicit in decision under uncertainty by equating the utility of a constant act with the utility of its consequence. Important particular cases of Sugeno integrals such as prioritized minimum and maximum operators, their ordered versions, and Boolean max-min functions are studied. [less ▲]

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See detailThe phylogeny of Nudibranchia (Opisthobranchia, Gastropoda, Mollusca) reconstructed by three molecular markers
Wollscheid-Lengeling, Evi UL; Boore, Jeffrey; Brown, Wesley et al

in Organisms Diversity and Evolution (2001), 1(4), 241-256

The phylogeny of the Nudibranchia and its major constituent taxa is investigated by comparing the complete sequences of the 18S rDNA of 54 species, a part of the 16S rDNA of 38 species and part of ... [more ▼]

The phylogeny of the Nudibranchia and its major constituent taxa is investigated by comparing the complete sequences of the 18S rDNA of 54 species, a part of the 16S rDNA of 38 species and part of cytochrome c oxidase I (cox1) of 45 species. These datasets are analyzed individually and in combination for the subset of taxa where information on all three markers is available. The results are compared to published cladistic analyses based on morphological data. The monophyly of the Nudibranchia and the monophyly of its two major groups, the Anthobranchia/Doridoidea and Cladobranchia, is confirmed. Incongruencies between the molecular and morphological data is discussed, as well as incongruencies between the three molecular markers. [less ▲]

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See detailOn the Equivalence of Taxes Paid by Employers and Employees
Picard, Pierre M UL; Toulemonde, Eric

in Scottish Journal of Political Economy (2001), 48(4), 461-70

In this paper we study the employment effects of a budget neutral restructuring of taxes levied on employers and employees. We derive conditions for taxes levied on workers to have the same employment ... [more ▼]

In this paper we study the employment effects of a budget neutral restructuring of taxes levied on employers and employees. We derive conditions for taxes levied on workers to have the same employment effects as taxes levied on firms under standard processes of wage determination. [less ▲]

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See detailZur Bedeutung des allgemeinen und aufgabenbezogenen Selbstvertrauens für das Bewegungslernen
Bund, Andreas UL

in Psychologie und Sport (2001), 8

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See detailGlobal stability of relay feedback systems
Goncalves, Jorge UL; Megretski, A.; Dahleh, M. A.

in IEEE Transactions on Automatic Control (2001), 46(4), 550--562

For a large class of relay feedback systems (RFS) there will be limit cycle oscillations. Conditions to check existence and local stability of limit cycles for these systems are well known. Global ... [more ▼]

For a large class of relay feedback systems (RFS) there will be limit cycle oscillations. Conditions to check existence and local stability of limit cycles for these systems are well known. Global stability conditions, however, are practically nonexistent. This paper presents conditions in the form of linear matrix inequalities (LMIs) that, when satisfied, guarantee global asymptotic stability of limit cycles induced by relays with hysteresis in feedback with linear time-invariant (LTI) stable systems. The analysis consists in finding quadratic surface Lyapunov functions for Poincaré maps associated with RFS. These results are based on the discovery that a typical Poincaré map induced by an LTI flow between two hyperplanes can be represented as a linear transformation analytically parametrized by a scalar function of the state. Moreover, level sets of this function are convex subsets of linear manifolds. The search for quadratic Lyapunov functions on switching surfaces is done by solving a set of LMIs. Although this analysis methodology yields only a sufficient criterion of stability, it has proved very successful in globally analyzing a large number of examples with a unique locally stable symmetric unimodal limit cycle. In fact, it is still an open problem whether there exists an example with a globally stable symmetric unimodal limit cycle that could not be successfully analyzed with this new methodology. Examples analyzed include minimum-phase systems, systems of relative degree larger than one, and of high dimension. Such results lead us to believe that globally stable limit cycles of RFS frequently have quadratic surface Lyapunov functions. [less ▲]

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See detailOn comparison meaningfulness of aggregation functions
Marichal, Jean-Luc UL; Mathonet, Pierre UL

in Journal of Mathematical Psychology (2001), 45(2), 213-223

This paper will give a description of all continuous functions which are comparison meaningful in the sense of measurement theory.

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See detailJob additionality and deadweight spending in perfectly competitive industries
Picard, Pierre M UL

in Journal of Public Economics (2001), 79(3), 521-541

This paper links the old literature on employment subsidies with the current theories of contract and regulation. One important source of inefficiency of employment subsidies is non-additional employment ... [more ▼]

This paper links the old literature on employment subsidies with the current theories of contract and regulation. One important source of inefficiency of employment subsidies is non-additional employment and deadweight spending which occur when private firms receive a subsidy for jobs that would have been created without the subsidy. We identify the asymmetry of information between the government and the private firm as the source of these problems. When the government proposes optimal incentive contracts to promote employment, we show that all employment creations are additional and that the deadweight spending is equal to the information rent, which may be null when firms’ types are discrete. [less ▲]

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See detailDid women perform satirical poetry? Trobairitz and Soldadeiras in Medieval Occitan poetry
Leglu, Catherine UL

in Forum for Modern Language Studies (2001), 37(1), 15-25

Women poets (trobairitz) are named as authors of satirical poems of the 12th-13th centuries. It is not known if they were accepted culturally as performers. This chapter suggests that women performers are ... [more ▼]

Women poets (trobairitz) are named as authors of satirical poems of the 12th-13th centuries. It is not known if they were accepted culturally as performers. This chapter suggests that women performers are received in culturally-determined ways that can make it difficult to view their work solely as subsersive. [less ▲]

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