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See detailAsynchronous Near-Far Resistant DS-CDMA Receivers Without A Priori Synchronization
Parkvall, Stefan; Ström, Erik G.; Milstein, Laurence B. et al

in IEEE Transactions on Communications (1999), 47(1), 7888

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See detailReliable recovery of inbred mouse lines using cryopreserved spermatozoa.
Marschall, S.; Huffstadt, U.; Balling, Rudi UL et al

in Mammalian Genome (1999), 10(8), 773-6

Since the mouse has become the most detailed model system to investigate the genetics and pathogenesis of human diseases, large numbers of new mouse strains have and continue to be produced. In nearly all ... [more ▼]

Since the mouse has become the most detailed model system to investigate the genetics and pathogenesis of human diseases, large numbers of new mouse strains have and continue to be produced. In nearly all animal facilities, the maintenance of breeding colonies is limited and mouse strains have to be archived in an efficient way. This study was undertaken to test the reliability of recovering mouse lines by use of cryopreserved spermatozoa from individual male mice. In contrast to many studies, spermatozoa and oocytes were derived from the same genetic background. 30 C3HeB/FeJ males belonging to three different categories (wild-type, F1-generation of ENU-treated males, and defined mutants) were recovered by producing at least 20 offspring from each donor. Independent of the experimental group, every single male was successfully recovered. Archiving mouse strains by cryopreservation of spermatozoa may, therefore, offer a reliable way to preserve genetically valuable mouse strains and provides an efficient management strategy for animal facilities. [less ▲]

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See detailAnalogues and homologues of N-palmitoylethanolamide, a putative endogenous CB(2) cannabinoid, as potential ligands for the cannabinoid receptors
Lambert, D. M.; DiPaolo, F. G.; Sonveaux, P. et al

in Biochimica et Biophysica Acta (1999), 1440(2-3), 266-74

The presence of CB(2) receptors was reported in the rat basophilic cell line RBL-2H3 and N-palmitoylethanolamide was proposed as an endogenous, potent agonist of this receptor. We synthesized a series of ... [more ▼]

The presence of CB(2) receptors was reported in the rat basophilic cell line RBL-2H3 and N-palmitoylethanolamide was proposed as an endogenous, potent agonist of this receptor. We synthesized a series of 10 N-palmitoylethanolamide homologues and analogues, varying by the elongation of the fatty acid chain from caproyl to stearoyl and by the nature of the amide substituent, respectively, and evaluated the affinity of these compounds to cannabinoid receptors in the rat spleen, RBL-2H3 cells and CHO-CB(1) and CHO-CB(2) receptor-transfected cells. In rat spleen slices, CB(2) receptors were the predominant form of the cannabinoid receptors. No binding of [(3)H]SR141716A was observed. [(3)H]CP-55,940 binding was displaced by WIN 55,212-2 and anandamide. No displacement of [(3)H]CP-55,940 or [(3)H]WIN 55,212-2 by palmitoylethanolamide derivatives was observed in rat spleen slices. In RBL-2H3 cells, no binding of [(3)H]CP-55,940 or [(3)H]WIN 55,212-2 could be observed and conversely, no inhibitory activity of N-palmitoylethanolamide derivatives and analogues was measurable. These compounds do not recognize the human CB(1) and CB(2) receptors expressed in CHO cells. In conclusion, N-palmitoylethanolamide was, in our preparations, a weak ligand while its synthesized homologues or analogues were essentially inactive. Therefore, it seems unlikely that N-palmitoylethanolamide is an endogenous agonist of the CB(2) receptors but it may be a compound with potential therapeutic applications since it may act via other mechanisms than cannabinoid CB(1)-CB(2) receptor interactions. [less ▲]

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See detailA kurtosis-based dynamic approach to Gaussian mixture modeling
Vlassis, Nikos UL; Likas, A.

in IEEE Transactions on Systems, Man and Cybernetics. Part A, Systems and Humans (1999), 29(4), 393-399

We address the problem of probability density function estimation using a Gaussian mixture model updated with the expectation-maximization (EM) algorithm. To deal with the case of an unknown number of ... [more ▼]

We address the problem of probability density function estimation using a Gaussian mixture model updated with the expectation-maximization (EM) algorithm. To deal with the case of an unknown number of mixing kernels, we define a new measure for Gaussian mixtures, called total kurtosis, which is based on the weighted sample kurtoses of the kernels. This measure provides an indication of how well the Gaussian mixture fits the data. Then we propose a new dynamic algorithm for Gaussian mixture density estimation which monitors the total kurtosis at each step of the Ehl algorithm in order to decide dynamically on the correct number of kernels and possibly escape from local maxima. We show the potential of our technique in approximating unknown densities through a series of examples with several density estimation problems. [less ▲]

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See detailInterleukin-6 and oncostatin M-induced growth inhibition of human A375 melanoma cells is STAT-dependent and involves upregulation of the cyclin-dependent kinase inhibitor p27/Kip1
Kortylewski, M.; Heinrich, P. C.; Mackiewicz, A. et al

in Oncogene (1999), 18(25), 3742-53

Interleukin-6 (IL-6)-type cytokines lead to growth arrest of human A375 melanoma cells. The present study demonstrates that this effect depends on the activation of STAT transcription factors. We observed ... [more ▼]

Interleukin-6 (IL-6)-type cytokines lead to growth arrest of human A375 melanoma cells. The present study demonstrates that this effect depends on the activation of STAT transcription factors. We observed a correlation between the extent of growth inhibition exerted by IL-6, IL-6 plus soluble IL-6 receptor or oncostatin M (OSM) and the intensities of STAT3 and STAT1 signals. A truncated chimeric receptor retaining only the membrane-proximal region of gp130, the common signal transducer of IL-6-type cytokines, did neither activate STATs nor mediate growth arrest of stable transfectants. These functions were restored by the addition of short STAT recruitment modules comprising critical tyrosine residues from gp130 (Y767, Y814). A receptor carrying tyrosine module Y759 of gp130 effectively mediated activation of the phosphatase SHP-2 but did not alter cell growth. Overexpression of dominant negative forms of STAT3 but not STAT1 abrogated the inhibitory effect of OSM and IL-6 in A375 cells. In addition, we have identified the cyclin-dependent kinase inhibitor p27/Kipl as a novel target to be regulated by IL-6-type cytokines. Stimulation-dependent upregulation of p27 mRNA occurred STAT3-dependently. Also p27 protein accumulated which coincided with the disappearance of hyperphosphorylated retinoblastoma protein in three human melanoma cell lines sensitive to IL-6-type cytokines. [less ▲]

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See detailKardiovaskuläre Reaktivität und die Entwicklung der essentiellen Hypertonie
Vögele, Claus UL

in Verhaltensmodifikation und Verhaltensmedizin (1999), (20), 321-342

Psychophysiological experiments show large individual differences in physiological reactivity to mental stress. Hyperreactivity refers to the propensity for an individual to exhibit increased ... [more ▼]

Psychophysiological experiments show large individual differences in physiological reactivity to mental stress. Hyperreactivity refers to the propensity for an individual to exhibit increased cardiovascular activity during exposure to external stimuli when compared to controls. Essential hypertensives show cardiovascular hyperreactivity that is not reflected in electrodermal or respiratory activity. This result indicates that cardiovascular reactivity could be an important component in the development of essential hypertension. This article provides an overview of conceptual issues and empirical findings concerning the role of cardiovascular reactivity and the development of essential hypertension. [less ▲]

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See detailCognitive support methods for multi-criteria expert decision making
Bisdorff, Raymond UL

in European Journal of Operational Research (1999), 119(2), 379-387

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See detailJEX Nîmes, 9 juin 1998
Cuniberti, Gilles UL

in Recueil Dalloz (1999)

Compétence internationale en matière de mesures conservatoires.

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See detailEffect of SK&F 96365 on extracellular Ca2+ -dependent O2- production in neutrophil-like HL-60 cells
Gallois, A.; Bueb, Jean-Luc UL; Tschirhart, Eric UL

in European Journal of Pharmacology (1999), 361(2-3), 293-8

Store-operated Ca2+ entry is referred to a capacitative current activated by Ca2+ -stores depletion in various non-excitable cells. Neutrophil-like HL-60 cells responded to N-formyl-L-Methionyl-L-Leucyl-L ... [more ▼]

Store-operated Ca2+ entry is referred to a capacitative current activated by Ca2+ -stores depletion in various non-excitable cells. Neutrophil-like HL-60 cells responded to N-formyl-L-Methionyl-L-Leucyl-L-Phenylalanine (fMLP) by an early O2- production preceded by a [Ca2+]i rise. Cell stimulation in the absence of extracellular Ca2+ resulted in a major reduction of [Ca2+]i rise and O2- production. A purported inhibitor of store-operated Ca2+ entry, SK&F 96365 (1-(beta-(3-(4-methoxy-phenyl)propoxyl)-4-methoxy-phenetyl)- 1H-imidazole hydrochloride), inhibited extracellular Ca2+ -dependent [Ca2+]i rise by 30% but did not alter O2- production. In conclusion, SK&F 96365 did not modify extracellular Ca2+ -dependent O2- production, despite a significant but limited reduction in fMLP-activated membrane Ca2+ fluxes which can be ascribed to store-operated Ca2+ entry. Furthermore, Ca2+ influx is necessary for a full induction and maintenance of the biological response. [less ▲]

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See detailModified IQML and Weighted Subspace Fitting without Eigendecomposition
Kristensson, Martin; Jansson, Magnus; Ottersten, Björn UL

in Signal Processing (1999), 79(1), 2944

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See detailAn Improved MUSIC Algorithm for Estimation of Time Delays in Asynchronous DS-CDMA Systems
Östman, Thomas; Parkvall, Stefan; Ottersten, Björn UL

in IEEE Transactions on Communications (1999), 47(11), 16281631

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See detailVillin function in the organization of the actin cytoskeleton. Correlation of in vivo effects to its biochemical activities in vitro.
Friederich, Evelyne UL; Vancompernolle, K.; Louvard, D. et al

in The Journal of biological chemistry (1999), 274(38), 26751-60

Villin is an actin-binding protein of the intestinal brush border that bundles, nucleates, caps, and severs actin in a Ca(2+)-dependent manner in vitro. Villin induces the growth of microvilli in ... [more ▼]

Villin is an actin-binding protein of the intestinal brush border that bundles, nucleates, caps, and severs actin in a Ca(2+)-dependent manner in vitro. Villin induces the growth of microvilli in transfected cells, an activity that requires a carboxyl-terminally located KKEK motif. By combining cell transfection and biochemical assays, we show that the capacity of villin to induce growth of microvilli in cells correlates with its ability to bundle F-actin in vitro but not with its nucleating activity. In agreement with its importance for microfilament bundling in cells, the KKEK motif of the carboxyl-terminal F-actin-binding site is crucial for bundling in vitro. In addition, substitutions of basic residues in a second site, located in the amino-terminal portion of villin, impaired its activity in cells and reduced its binding to F-actin in the absence of Ca(2+) as well as its bundling and severing activities in vitro. Altogether, these findings suggest that villin participates in the organization and stabilization of the brush border core bundle but does not initiate its assembly by nucleation of actin filaments. [less ▲]

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See detailNetwork of Superconducting Gravimeters Benefits a Number of Disciplines
Crossley, D.; Hinderer, J.; Casula, G. et al

in EOS (1999), 80(11), 121-126

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See detailMobilität und Verkehr in Ostdeutschland. Auflösung der Städte, Verflüssigung der Lebensstile, Freiheit statt Planung?
Hesse, Markus UL

in Kommune: Forum für Politik, Ökonomie, Kultur (1999), 17(12), 30-36

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See detailA support theorem for the filter under infinite dimensional noise and unbounded observation coefficient
Schiltz, Jang UL

in Applied Mathematics & Optimization (1999), 39

In this paper we consider a nonlinear filtering problem with an unbounded observation coefficient, correlated noises, and a signal process driven by an infinite dimensional Brownian motion. We prove that ... [more ▼]

In this paper we consider a nonlinear filtering problem with an unbounded observation coefficient, correlated noises, and a signal process driven by an infinite dimensional Brownian motion. We prove that the unnormalized filter admits a smooth density which is in the Schwartz space and we give a description of the support of the law of this density. [less ▲]

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See detailIntercomparison between the FG5 202 and FGG 206 at the site of the superconducting gravimeter C021 in Membach (Belgium)
Francis, Olivier UL; Amalvict, M.; Hinderer, J.

in Bulletin d'Information du Bureau Gravimétrique International (1999), (84), 36-39

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See detailNeuroIdentifier: Tool zur Identifikation dynamischer Systeme mit neuronalen Netzen
Habtom, Ressom; Voos, Holger UL; Litz, Lothar

in Automatisierungstechnik (1999), 47(4), 181-182

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See detailDie Wahrnehmung von Persönlichkeitseigenschaften und ihrer Zusammenhänge: ein Methodenvergleich
Krolak-Schwerdt, Sabine UL

in Zeitschrift für Sozialpsychologie (1999), 30

The present paper is focused on the topic of the cognitive organization of trait descriptive terms which are used frequently in ordinary language. Three studies were conducted to assess the impact of ... [more ▼]

The present paper is focused on the topic of the cognitive organization of trait descriptive terms which are used frequently in ordinary language. Three studies were conducted to assess the impact of different data gathering techniques on the typological results. In study I the sorting technique was used in which subjects were asked to partition the set of personality trait names into different groups, each group representing a different person. Study II consisted of a variant of the sorting method in which subjects had to successively collect terms into one group describing a person several times. In study III a trait rating task was conducted. Since it was assumed theoretically that trait descriptive terms are organized by implicit personality dimensions and prototypes, respectively, the data were analyzed by hierarchical clustering and multidimensional scaling methods. Clustering solutions and dimensional configurations were obtained which varied largely between the data gathering techniques. Furthermore, the techniques differ markedly in the stability of the classificatory representations they induce. Issues concerning major drawbacks of methods of data acquisition and data analysis are discussed. [less ▲]

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See detailSelective differentiation and proliferation of human eosinophils from umbilical cord blood: calcium fluxes and superoxide ion secretion
Zardini, D. M.; Tschirhart, Eric UL

in Thérapie (1999), 54(1), 103-9

Investigation of the physiologic mechanisms involved in the activation of eosinophils is crucial to comprehend their role in the pathogenesis of allergic reactions. To overcome the difficulty of obtaining ... [more ▼]

Investigation of the physiologic mechanisms involved in the activation of eosinophils is crucial to comprehend their role in the pathogenesis of allergic reactions. To overcome the difficulty of obtaining large numbers of eosinophils, we differentiated in vitro eosinophils from human umbilical cord blood mononuclear cells. These cells responded to fMLP or PAF with an increase in [Ca2+]i, associated with O2 production. Deprivation or chelation of extracellular calcium induced a reduction of fMLP or PAF-induced [Ca2+]i rise and O2- production. Similar results were obtained with extracellular Ni2+ addition. Chelation of intracellular calcium induced an inhibition of fMLP- or PAF-induced [Ca2+]i rise and a decrease in O2- production. Our results indicate that fMLP- and PAF-dependent O2- production in eosinophils requires intra- and extracellular Ca2+ and that Ca2+ influx is necessary for optimal activation. [less ▲]

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See detailOverexpression of activin A in the skin of transgenic mice reveals new activities of activin in epidermal morphogenesis, dermal fibrosis and wound repair.
Munz, B.; Smola, H.; Engelhardt, F. et al

in EMBO Journal (1999), 18(19), 5205-15

Recently we demonstrated a strong induction of activin expression after skin injury, suggesting a function of this transforming growth factor-beta family member in wound repair. To test this possibility ... [more ▼]

Recently we demonstrated a strong induction of activin expression after skin injury, suggesting a function of this transforming growth factor-beta family member in wound repair. To test this possibility, we generated transgenic mice that overexpress the activin betaA chain in the epidermis under the control of a keratin 14 promoter. The transgenic mice were significantly smaller than control littermates, and they had smaller ears and shorter tails. In their skin, the fatty tissue was replaced by connective tissue and a severe thickening of the epidermis was found. The spinous cell layer was significantly increased, and the epidermal architecture was highly disorganized. These histological abnormalities seem to result from increased proliferation of the basal keratinocytes and abnormalities in the program of keratinocyte differentiation. After skin injury, a significant enhancement of granulation tissue formation was detected in the activin-overexpressing mice, possibly as a result of premature induction of fibronectin and tenascin-C expression. These data reveal novel activities of activin in the regulation of keratinocyte proliferation and differentiation as well as in dermal fibrosis and cutaneous wound repair. [less ▲]

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See detailInduction of Egr-1 mRNA and protein by endothelin 1, angiotensin II and norepinephrine in neonatal cardiac myocytes.
Shamim, A.; Pelzer, T.; Grohe, C. et al

in Molecular and Cellular Biochemistry (1999), 195(1-2), 11-7

The early growth response gene Egr-1 is a nuclear transcription factor known to serve as an intermediary in a broad range of signal transduction processes. Recent studies have assigned Egr-1 a new role as ... [more ▼]

The early growth response gene Egr-1 is a nuclear transcription factor known to serve as an intermediary in a broad range of signal transduction processes. Recent studies have assigned Egr-1 a new role as an amplifier of gene expression. Egr-1 mRNA is expressed in the myocardium and is rapidly induced in response to hypertrophic stimuli. However, induction of the Egr-1 protein has not yet been demonstrated in the myocardium; on the other hand, in skeletal muscle cells we have shown translational regulation of Egr-1. To further investigate the role of Egr-1 in the regulatory mechanisms of a variety of signal transduction processes we have therefore asked whether bona fide hypertrophic stimuli induce Egr-1 protein subsequently to its mRNA in neonatal rat cardiomyocytes or whether translational block occurs. In confocal laser studies the Egr-1 protein was nuclearly localized. Norepinephrine (NE, 2 microM), angiotensin II (AII, 0.1 microM), and endothelin 1 (E1, 0.1 microM) each induced the Egr-1 mRNA 6-8 fold and the Egr-1 protein 3-5 fold (n = 3, p < 0.01). Therefore, in contrast to skeletal muscle cells, these stimuli increased Egr-1 mRNA and protein levels. These results point further to the role of Egr-1 as a possible amplifier of signal transduction in the myocardium. [less ▲]

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See detailForce obligatoire et contenu obligationnel du contrat
Ancel, Pascal UL

in Revue Trimestrielle de Droit Civil (1999)

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See detailAn infinite tower of genus 2 curves related to the Kowalewski top
Leprévost, Franck UL; Markushevich, Dimitri

in Journal für die Reine und Angewandte Mathematik (1999), 514

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See detailReview of: T. Hoenselaars and M. Buning (eds) English Literature and the Other Languages
Weber, Jean-Jacques UL

in European English Messenger (1999), 8

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See detailModelling the influence of grain-size-dependent solute drag on the kinetics of grain growth in nanocrystalline materials
Michels, Andreas UL; Krill, C. E.; Ehrhardt, H. et al

in Acta Materialia (1999), 47(7), 2143-2152

The large relative change in total grain-boundary area that accompanies grain growth in a nanocrystalline material has a potentially strong influence on the kinetics of grain growth whenever grain ... [more ▼]

The large relative change in total grain-boundary area that accompanies grain growth in a nanocrystalline material has a potentially strong influence on the kinetics of grain growth whenever grain-boundary migration is controlled by solute (impurity) drag. As the grain-boundary area decreases, the concentration of solute or impurity atoms segregated to the boundaries is expected to increase rapidly, introducing a grain-size dependence to the retarding force on boundary migration. We have modified the Burke equation—which assumes the drag force to be independent of the average grain size—to take into account a linear dependence of grain-boundary pinning on grain size. The form of the resulting grain-growth curve is surprisingly similar to Burke's solution; in fact, a constant rescaling of the boundary mobility parameter is sufficient to map one solution approximately onto the other. The activation energies for grain-boundary motion calculated from the temperature dependence of the mobility parameter are therefore identical for both models. This fact provides an explanation for the success of Burke's solution in fitting grain-growth data obtained in systems, such as nanocrystalline materials, for which the assumption of grain-size-independent solute drag is incorrect. [less ▲]

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See detailSmall-angle neutron scattering by the magnetic microstructure of nanocrystalline ferromagnets near saturation
Weissmüller, J.; McMichael, R. D.; Michels, Andreas UL et al

in Journal of Research of the National Institute of Standards and Technology (1999), 104(3), 261-275

The paper presents a theoretical analysis of elastic magnetic small-angle neutron scattering (SANS) due to the nonuniform magnetic microstructure in nanocrystalline ferromagnets. The reaction of the ... [more ▼]

The paper presents a theoretical analysis of elastic magnetic small-angle neutron scattering (SANS) due to the nonuniform magnetic microstructure in nanocrystalline ferromagnets. The reaction of the magnetization to the magnetocrystalline and magnetoelastic anisotropy fields is derived using the theory of micromagnetics. In the limit where the scattering volume is a single magnetic domain, and the magnetization is nearly aligned with the direction of the magnetic field, closed form solutions are given for the differential scattering cross-section as a function of the scattering vector and of the magnetic field. These expressions involve an anisotropy field scattering function, that depends only on the Fourier components of the anisotropy field microstructure, not on the applied field, and a micromagnetic response function for SANS, that can be computed from tabulated values of the materials parameters saturation magnetization and exchange stiffness constant or spin wave stiffness constant. Based on these results, it is suggested that the anisotropy field scattering function SH can be extracted from experimental SANS data. A sum rule for SH suggests measurement of the volumetric mean square anisotropy field. When magneto-crystalline anisotropy is dominant, then a mean grain size or the grain size distribution may be determined by analysis of SH. [less ▲]

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See detailLes standards cryptographiques du XXI-eme siecle : AES et IEEE-P1363
Leprévost, Franck UL

in Gazette des Mathématiciens (1999)

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See detailEffects of nicotine administered via a transdermal delivery system on vigilance: a repeated measure study.
Mancuso, Giovanna UL; Andres, Pilar; Ansseau, Marc et al

in Psychopharmacology (1999), 142(1), 18-23

Fifteen 18- to 25-year-old male smokers were tested in a within-subjects design to determine the influence of a transdermal patch of 21 mg nicotine on vigilance. Subjects were tested on the RVIP test ... [more ▼]

Fifteen 18- to 25-year-old male smokers were tested in a within-subjects design to determine the influence of a transdermal patch of 21 mg nicotine on vigilance. Subjects were tested on the RVIP test (Rapid Visual Information Processing test) 1.30, 3.00 and 6.30 h after patch application, to verify the involvement of the dose of nicotine on the performance. This study confirms and extends the increasing effects of nicotine on vigilance previously found with orally and transdermally given nicotine. Moreover, it showed that such performance was independent of the time of nicotine absorption (1.30, 3.00 and 6.30 h after patch application), which suggests that a relatively low dose of nicotine suffices to activate vigilance processing. Regarding motor performance, no convincing effect of nicotine was observed on reaction time. [less ▲]

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See detailNotochord-dependent expression of MFH1 and PAX1 cooperates to maintain the proliferation of sclerotome cells during the vertebral column development.
Furumoto, T. A.; Miura, N.; Akasaka, T. et al

in Developmental Biology (1999), 210(1), 15-29

During axial skeleton development, the notochord is essential for the induction of the sclerotome and for the subsequent differentiation of cartilage forming the vertebral bodies and intervertebral discs ... [more ▼]

During axial skeleton development, the notochord is essential for the induction of the sclerotome and for the subsequent differentiation of cartilage forming the vertebral bodies and intervertebral discs. These functions are mainly mediated by the diffusible signaling molecule Sonic hedgehog. The products of the paired-box-containing Pax1 and the mesenchyme forkhead-1 (Mfh1) genes are expressed in the developing sclerotome and are essential for the normal development of the vertebral column. Here, we demonstrate that Mfh1 like Pax1 expression is dependent on Sonic hedgehog signals from the notochord, and Mfh1 and Pax1 act synergistically to generate the vertebral column. In Mfh1/Pax1 double mutants, dorsomedial structures of the vertebrae are missing, resulting in extreme spina bifida accompanied by subcutaneous myelomeningocoele, and the vertebral bodies and intervertebral discs are missing. The morphological defects in Mfh1/Pax1 double mutants strongly correlate with the reduction of the mitotic rate of sclerotome cells. Thus, both the Mfh1 and the Pax1 gene products cooperate to mediate Sonic hedgehog-dependent proliferation of sclerotome cells. [less ▲]

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See detailComputing Discrete Logarithms in Real Quadratic Congruence Function Fields of Large Genus
Müller, Volker UL; Stein, Andreas; Thiel, Christoph

in Mathematics of Computation (1999), 68(226), 807-822

We present a sub-exponential algorithm for computing discrete loga­rithms in real quadratic congruence function fields of sufficiently large genus. We prove the correctness and the expected running time ... [more ▼]

We present a sub-exponential algorithm for computing discrete loga­rithms in real quadratic congruence function fields of sufficiently large genus. We prove the correctness and the expected running time of the algorithm. The algorithm is a gene­ralization of a similar algorithm for quadratic number fields. [less ▲]

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See detail«La figure de Bélisaire chez Marmontel et Diderot»
Roelens, Nathalie UL

in Voir (1999)

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See detailThe case of thresholdless antiferroelectricity: Polarization-stabilized twisted SmC* liquid crystals give V-shaped electro-optic response
Rudquist, Per; Lagerwall, Jan UL; Buivydas, M. et al

in Journal of Materials Chemistry (1999), 9(6), 1257-1261

We have studied the three-component liquid crystal mixture reported to exhibit ‘thresholdless antiferroelectricity’ [Inui et al., J. Mater. Chem, 1996, 6, 671]. We find that the thresholdless or V-shaped ... [more ▼]

We have studied the three-component liquid crystal mixture reported to exhibit ‘thresholdless antiferroelectricity’ [Inui et al., J. Mater. Chem, 1996, 6, 671]. We find that the thresholdless or V-shaped switching is obtained in thf absence of antiferroelectricity. This analog electro-optic response is due to the field-induced switching of a twisted smectic C* structure stabilized by polar surface interactions and by electrostatic bulk polarization charge interactions. The latter confine the director twist to thin surface regions leaving the bulk of the cell uniform, which gives good extinction at zero field. In sufficiently thin cells, such thresholdless switching can in fact be followed down to much lower temperatures, where the bulk would be antiferroelectric, but is maintained in the cells in the ferroelectric state by hysteresis from surface action. [less ▲]

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See detailGenotypic and antigenic characterization of hemagglutinin proteins of African measles virus isolates
Truong, A. T.; Kreis, Stephanie UL; Ammerlaan, W. et al

in Virus Research (1999), 62(1), 89-95

A comprehensive phylogenetic study based on the hemagglutinin (H) protein of all known African measles virus (MV) isolates is presented. The study includes 64 new H gene sequences from Ghana, Nigeria and ... [more ▼]

A comprehensive phylogenetic study based on the hemagglutinin (H) protein of all known African measles virus (MV) isolates is presented. The study includes 64 new H gene sequences from Ghana, Nigeria and South Africa as well as viruses from Zambia and The Gambia for which only incomplete sequencing data were available and that have previously not been genotyped. The results provide further support to the tentative assignment of the Nigerian and Ghanaian viruses to a new genotype B3 within clade B. A distinct geographic distribution pattern emerged with clade B viruses circulating exclusively in African countries north of the equator. All MV strains from southern Africa grouped in clades A and D with the majority of viruses belonging to genotype D4. The viruses considerably differed by their sensitivity to neutralization by monoclonal antibodies (mAb), but three selected antibodies were sufficient to distinguish between African MVs representing four different genotypes. Copyright (C) 1999 Elsevier Science B.V. [less ▲]

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See detailDie Logik der kurzen Wege. Räumliche Mobilität und Verkehr als Gegenstand der Stadtforschung.
Hesse, Markus UL

in Erdkunde (1999), 53(4), 317-329

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See detailClassification of Combustion Regimes in a Packed Bed of Particles Based on the Relevant Time and Length Scales
Peters, Bernhard UL

in Combustion and Flame (1999), 116(1-2), 297-301

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See detailEditorial
Tröhler, Daniel UL

in Neue Pestalozzi-Blätter (1999), 5(2), 1-1

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See detailPerinatal risk factors for childhood type 1 diabetes in Europe. The EURODIAB Substudy 2 Study Group.
Dahlquist, G.G.; Patterson, C.; Soltesz, G. et al

in Diabetes Care (1999), 22(10), 1698-1702

OBJECTIVE: To explore whether perinatal factors are associated with the development of childhood type 1 diabetes. RESEARCH DESIGN AND METHODS: We studied hospital records from 892 cases of childhood type ... [more ▼]

OBJECTIVE: To explore whether perinatal factors are associated with the development of childhood type 1 diabetes. RESEARCH DESIGN AND METHODS: We studied hospital records from 892 cases of childhood type 1 diabetes compared with 2,291 population-based control subjects in seven study centers in Europe. RESULTS: In a pooled analysis incorporating stratification by center, we confirmed the previous findings that older maternal age, maternal preeclampsia, neonatal respiratory disease, and jaundice caused by blood group incompatibility are significant risk factors for type 1 diabetes, whereas being a firstborn child, having a low birth weight, or having a short birth length were protective. Cesarean section delivery and neonatal infectious diseases were not significantly associated with the risk of type 1 diabetes in this study. The strongest association was found for blood group incompatibility (AB0 and Rh factor) with an odds ratio (OR) of 2.96 (95% CI 1.88-4.65). AB0 incompatibility (OR = 3.92) was a more common and also a stronger risk factor than Rh incompatibility (OR = 1.62). The effect of AB0 blood group incompatibility was independent of treatment effects in logistical regression analysis. CONCLUSIONS: Different perinatal events are associated with an increased risk of type 1 diabetes. The effect of maternal-child blood group incompatibility is strong and indicates a true effect that must be further explored. [less ▲]

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See detailRelease of O2- by human umbilical cord blood-derived eosinophils: role of intra- and extracellular calcium
Zardini, D. M.; Bueb, Jean-Luc UL; Tschirhart, Eric UL

in Cell Calcium (1999), 25(5), 381-9

The aim of our study was to investigate the physiologic mechanisms involved in eosinophil activation as an essential prerequisite to disrupting the biochemical cascade that triggers inflammation, thereby ... [more ▼]

The aim of our study was to investigate the physiologic mechanisms involved in eosinophil activation as an essential prerequisite to disrupting the biochemical cascade that triggers inflammation, thereby attenuating the effect of this activation or, ideally, preventing it from occurring. We have, therefore, examined the nature of the fMLP- and PAF-induced [Ca2+]i rise and the relationship between the [Ca2+]i rise and O2- production in human umbilical cord blood-derived eosinophils cultured in the presence of IL-3 and IL-5. These cells responded to fMLP or PAF (1 microM each) with an increase in [Ca2+]i (217.3 +/- 22.1 and 197.8 +/- 22.1 nM respectively) which was associated with production of O2- (40.2 +/- 8.2 and 35.2 +/- 7.6 pmol/min/10(6) cells respectively). The role of Ca2+ in the induced respiratory burst was studied by changing the availability of Ca2+ in the intra- and extracellular compartments. Removal or chelation of extracellular Ca2+ induced a reduction of both the fMLP and PAF-induced [Ca2+]i rise and O2- production. Chelation of intracellular Ca2+ induced a concentration-dependent inhibition of fMLP- and PAF-induced [Ca2+]i rise and caused a decrease in O2- production. SK&F 96365 had a stimulatory effect on PAF-induced [Ca2+]i rise and on fMLP-induced O2- production, this phenomenon was not observed with extracellular Ca2+ removal or chelation. Furthermore, Ni2+ exhibited an inhibition of both fMLP and PAF-induced [Ca2+]i rise and O2- production. Finally, both fMLP and PAF induced an increase in divalent cation influx that was further augmented by thapsigargin. Our results indicate that fMLP and PAF dependent O2- production in human eosinophils require intra- and extracellular Ca2+ and that Ca2+ influx is necessary for optimal activation. [less ▲]

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See detailTailchaser (Tlc): a new mouse mutation affecting hair bundle differentiation and hair cell survival.
Kiernan, A. E.; Zalzman, M.; Fuchs, H. et al

in Journal of Neurocytology (1999), 28(10-11), 969-85

We have undertaken a phenotypic approach in the mouse to identifying molecules involved in inner ear function by N-ethyl-N-nitrosourea mutagenesis followed by screening for new dominant mutations ... [more ▼]

We have undertaken a phenotypic approach in the mouse to identifying molecules involved in inner ear function by N-ethyl-N-nitrosourea mutagenesis followed by screening for new dominant mutations affecting hearing or balance. The pathology and genetic mapping of the first of these new mutants, tailchaser (Tlc), is described here. Tlc/+ mutants display classic behavioural symptoms of a vestibular dysfunction, including head-shaking and circling. Behavioural testing of ageing mice revealed a gradual deterioration of both hearing and balance function, indicating that the pathology caused by the Tlc mutation is progressive, similar to many dominant nonsyndromic deafnesses in humans. Based on scanning electron microscopy (SEM) studies, Tlc clearly plays a developmental role in the hair cells of the cochlea since the stereocilia bundles fail to form the characteristic V-shape pattern around the time of birth. By young adult stages, Tlc/+ outer hair bundles are grossly disorganised although inner hair bundles appear relatively normal by SEM. Increased compound action potential thresholds revealed that the Tlc/+ cochlear hair cells were not functioning normally in young adults. Similar to inner hair cells, the hair bundles of the vestibular hair cells also do not appear grossly disordered. However, all types of hair cells in the Tlc/+ inner ear eventually degenerate, apparently regardless of the degree of organisation of their hair bundles. We have mapped the Tlc mutation to a 12 cM region of chromosome 2, between D2Mit164 and D2Mit423. Based on the mode of inheritance and map location, Tlc appears to be a novel mouse mutation affecting both hair cell survival and stereocilia bundle development. [less ▲]

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See detailZic1 regulates the patterning of vertebral arches in cooperation with Gli3.
Aruga, J.; Mizugishi, K.; Koseki, H. et al

in Mechanisms of Development (1999), 89(1-2), 141-50

Skeletal abnormalities are described that appeared in Zic1-deficient mice. These mice show multiple abnormalities in the axial skeleton. The deformities are severe in the dorsal parts of the vertebrae ... [more ▼]

Skeletal abnormalities are described that appeared in Zic1-deficient mice. These mice show multiple abnormalities in the axial skeleton. The deformities are severe in the dorsal parts of the vertebrae, vertebral arches, but less so in the vertebral bodies (spina bifida occulta). The proximal ribs are deformed having ectopic processes. The abnormalities found in the vertebral arches can be traced back to disturbed segmental patterns of dorsal sclerotome. The Zic1/Gli3 double mutants showed severe abnormalities of vertebral arches not found in single mutants. The abnormalities in the vertebral arches were less severe in Zic1/Pax1 mutants than Zic1/Gli3 mutants, but significantly more pronounced than in Zic1 single mutants. The three genes may act synergistically in the development of the vertebral arches. [less ▲]

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See detailCharacterization and binding specificity of the monomeric STAT3-SH2 domain.
Haan, Serge UL; Hemmann, U.; Hassiepen, U. et al

in Journal of Biological Chemistry (1999), 274(3), 1342-8

Signal transducers and activators of transcription (STATs) are important mediators of cytokine signal transduction. STAT factors are recruited to phosphotyrosine-containing motifs of activated receptor ... [more ▼]

Signal transducers and activators of transcription (STATs) are important mediators of cytokine signal transduction. STAT factors are recruited to phosphotyrosine-containing motifs of activated receptor chains via their SH2 domains. The subsequent tyrosine phosphorylation of the STATs leads to their dissociation from the receptor, dimerization, and translocation to the nucleus. Here we describe the expression, purification, and refolding of the STAT3-SH2 domain. Proper folding of the isolated protein was proven by circular dichroism and fluorescence spectroscopy. The STAT3-SH2 domain undergoes a conformational change upon dimerization. Using an enzyme-linked immunosorbent assay we demonstrate that the monomeric domain binds to specific phosphotyrosine peptides. The specificity of binding to phosphotyrosine peptides was assayed with the tyrosine motif encompassing Tyr705 of STAT3 and with all tyrosine motifs present in the cytoplasmic tail of the signal transducer gp130. [less ▲]

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See detailDie Räume der Milieus. Neue Forschungsfragen zur Wechselwirkung von sozial-räumlichen Arrangements und Mobilität.
Hesse, Markus UL

in Ökologisches Wirtschaften (1999), 14(5-6), 23-25

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See detailStress and Family Satisfaction in Parents of Children with Port Wine Stains
Miller, A. Cate; Pit-Ten Cate, Ineke UL; Watson, Heather S. et al

in Pediatric Dermatology (1999), 16(3), 190-197

A cross-sectional survey was employed to assess parenting stress, family satisfaction, and parental concerns and to determine predictors of stress in parents of children with port-wine stains (PWSs). The ... [more ▼]

A cross-sectional survey was employed to assess parenting stress, family satisfaction, and parental concerns and to determine predictors of stress in parents of children with port-wine stains (PWSs). The participants were 46 parents of 24 children receiving treatment with pulsed dye laser photocoagulation for facial PWS at an outpatient dermatology clinic based at a university medical center. Outcome measures used were self-report instruments assessing psychosocial adjustment (Parenting Stress Index, Family Satisfaction Scale, and Parental Concerns Questionnaire). As a group, parents scored in the average range on the stress and family satisfaction measures when compared with a normative sample; five parents (11%) scored in the clinical range for stress. Forty-nine percent of the variance in parenting stress was accounted for by four variables: the child's age (beta = 0.34; p = 0.031), the parents' degree of family satisfaction (beta = -0.27; p = 0.077), the level of parental concern regarding the child's facial PWS (beta = 0.45; p = 0.005), and the parents' satisfaction with staff communication (beta = -0.51; p = 0.002). The data suggest that while, as a group, parents of children with a facial PWS report to be in the average range for psychological stress, some do not fare as well as others. Factors associated with lower stress include younger children, more family cohesion and adaptation, fewer parental concerns, and greater satisfaction with parent-staff communication. The potential for the development of medical complications and psychological problems over time suggests the need for treatment of the PWS at an early age. Health care providers should be prepared to screen for clinical levels of distress and to refer parents for psychological intervention when needed. [less ▲]

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See detailDirection Estimation in Partially Unknown Noise Fields
Göransson, Bo; Ottersten, Björn UL

in IEEE Transactions on Signal Processing (1999), 47

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See detailThe alpha1-antichymotrypsin A-allele in German Parkinson disease patients.
Grasbon-Frodl, E. M.; Egensperger, R.; Kosel, S. et al

in Journal of Neural Transmission (1999), 106(7-8), 729-36

An increased frequency of the A-allele of the alpha-antichymotrypsin (ACT) gene has been recently described in Japanese patients suffering from Parkinson disease (PD). In the present study, we have ... [more ▼]

An increased frequency of the A-allele of the alpha-antichymotrypsin (ACT) gene has been recently described in Japanese patients suffering from Parkinson disease (PD). In the present study, we have analyzed 62 German PD patients with regard to their ACT and APOE genotypes and compared them to 53 controls without clinical or pathological evidence of neurodegenerative disease. The A-allele frequency was 47% in PD patients compared to 54% in control cases excluding ACT as a major susceptibility factor for PD in the Caucasian population. Yet, ACT-A allele frequencies were significantly different (p < 0.001) between Japanese and German controls. Therefore, although our data do not suggest that the alpha1-ACT polymorphism is a significant risk factor for the development of PD, a consideration of differences in genetic background seems warranted when evaluating susceptibility factors for neurodegenerative disease. [less ▲]

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See detailNonlinear filtering with an infinite dimensional signal process
Schiltz, Jang UL; Boulanger, Christophe

in Portugaliae Matematicae (1999), 56

In this paper, we investigate a nonlinear ¯ltering problem with correlated noises, bounded coe±cients and a signal process evolving in an in¯nite dimensional space. We derive the Kushner{Stratonovich and ... [more ▼]

In this paper, we investigate a nonlinear ¯ltering problem with correlated noises, bounded coe±cients and a signal process evolving in an in¯nite dimensional space. We derive the Kushner{Stratonovich and the Zakai equation for the associated ¯lter respectively unnormalized ¯lter. A robust form of the Zakai equation is established for an uncorrelated ¯ltering problem. [less ▲]

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See detailManifold-valued martingales, changes of probabilities, and smoothness of finely harmonic maps
Arnaudon, Marc; Li, Xue-Mei; Thalmaier, Anton UL

in Annales de l'Institut Henri Poincare (B) Probability & Statistics (1999), 35(6), 765-791

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See detailTeeth. Where and how to make them.
Peters, H.; Balling, Rudi UL

in Trends in Genetics (1999), 15(2), 59-65

Organs have to develop at precisely determined sites to ensure functionality of the whole organism. Organogenesis is typically regulated by a series of interactions between morphologically distinct ... [more ▼]

Organs have to develop at precisely determined sites to ensure functionality of the whole organism. Organogenesis is typically regulated by a series of interactions between morphologically distinct tissues. The developing tooth of the mouse is an excellent model to study these processes and we are beginning to understand the networks regulating reciprocal tissue interactions at the molecular level. Synergistic and antagonistic effects of signaling molecules including FGFs and BMPs are recursively used to induce localized responses in the adjacent tissue layer (mesenchyme or epithelium). However, at different phases of odontogenesis these secreted growth factors have distinct effects and at the same time they are regulated by different upstream factors. The mesenchymal transcription factors Msx1 and Pax9 are initially regulated by epithelial FGFs and BMPs, but subsequently they function upstream of these signaling molecules. This cascade provides a molecular model by which reciprocal tissue interactions are controlled. [less ▲]

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See detailGauge-invariant theory for semiclassical magnetotransport through ballistic microstructures
Wirtz, Ludger UL; Tang, J. Z.; Burgdorfer, J.

in Physical Review B (1999), 59(4), 2956-2967

Within the semiclassical theory of magnetotransport through ballistic cavities, fluctuations in the transmission amplitude and in the conductance originate from the Aharonov-Bohm phase of directed areas ... [more ▼]

Within the semiclassical theory of magnetotransport through ballistic cavities, fluctuations in the transmission amplitude and in the conductance originate from the Aharonov-Bohm phase of directed areas. We formulate the semiclassical transmission amplitude in gauge-invariant form. The gauge invariant phases can be visualized in terms of areas enclosed by classical paths, which consist of the real path connecting the entrance point to the exit point and a virtual path leading back to the entrance point. We implement this method on different levels of a semiclassical description of magnetotransport with applications to magnetoconductance fluctuations and correlations. The validity of the semiclassical theories is analyzed. [S0163-1829(99)10903-2]. [less ▲]

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See detailCombined SSCP and heteroduplex analysis of the human plasma membrane Ca(2+)-ATPase isoform 1 in patients with essential hypertension.
Benkwitz, C.; Oberdorf-Maass, S.; Neyses, Ludwig UL

in Biochemical and biophysical research communications (1999), 261(2), 515-20

In recent theories concerning the pathogenesis of essential hypertension, altered calcium homeostasis plays an important role. Increased intracellular Ca(2+) levels have repeatedly been reported in ... [more ▼]

In recent theories concerning the pathogenesis of essential hypertension, altered calcium homeostasis plays an important role. Increased intracellular Ca(2+) levels have repeatedly been reported in different cell types of hypertensive subjects. In vascular smooth muscle cells the plasma membrane Ca(2+)-ATPase (PMCA) represents the most important Ca(2+)-ejection system. Modifications of this pump therefore have been assumed to increase contractile tone of small vessels. For this reason, the purpose of this study was to determine if genetic alterations in the hPMCA1 gene might be associated with arterial hypertension. For detection of polymorphisms all 22 PMCA1 exons from 44 patients with essential hypertension (based on rigorous clinical data in addition to a positive family history) and from 40 normotensives without a family history of hypertension were PCR amplified and subsequently subjected to combined single-strand conformation polymorphism (SSCP) and heteroduplex (HTX) analysis. Despite the high sensitivity of almost 100%, differences could not be identified between hypertensives and normotensives within the two groups. These data indicate that at least in this population PMCA1 polymorphisms are presumably not related to common forms of essential hypertension. Furthermore, the high degree of evolutionary conservation of the PMCA1 gene underlines the pivotal role of this ATPase for cell physiology. [less ▲]

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See detailCase report and molecular analysis of subacute sclerosing panencephalitis in a South African child
Vardas, E. A D; Leary, P. M. B; Yeats, J. C et al

in Journal of Clinical Microbiology (1999), 37(3), 775-777

This is the first case of subacute sclerosing panencephalitis from South Africa in which the molecular characteristics of the causative measles virus were examined. The virus found is classified as ... [more ▼]

This is the first case of subacute sclerosing panencephalitis from South Africa in which the molecular characteristics of the causative measles virus were examined. The virus found is classified as genotype D3, which has not previously been found in Africa and was last circulating in the United States before 1992. [less ▲]

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See detailThe dependence on the helical pitch of the antiferroelectric dielectric modes
Lagerwall, Jan UL; Fütterer, T.; Moro, D. et al

in Ferroelectrics (1999), 244

In an attempt to determine the physical nature of the low-frequency dielectric mode in antiferroelectric liquid crystals, we have studied the dielectric response in thick planar-oriented samples of ... [more ▼]

In an attempt to determine the physical nature of the low-frequency dielectric mode in antiferroelectric liquid crystals, we have studied the dielectric response in thick planar-oriented samples of Smectic C/sub A/* compounds undergoing a helix inversion. If the mode is collective there ought to be a minimum in the dielectric absorption due to the mode, at the temperature at which the helical pitch diverges. Although the effect is not large, we find minima for both antiferroelectric modes at this point, indicating that both modes are related to the helical director structure. A corresponding experiment has also been performed on a binary mixture which shows a helix inversion for a certain mixing ratio. However, because the effect in this case is overshadowed by unavoidable variations in other parameters, no minimum was detected. [less ▲]

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See detailLe coût de la durée du procéès pour les parties
Ancel, Pascal UL; Cottin, Marianne

in Revue Internationale de Droit Economique (1999), 2

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See detailEditorial
Tröhler, Daniel UL

in Neue Pestalozzi-Blätter (1999), 5(1), 1-1

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See detailVertical p-MOSFETs with gate oxide deposition before selective epitaxial growth
Moers, J.; Klaes, D.; Tönnesmann, A. et al

in Solid-State Electronics (1999), 43(1999), 529-535

A novel vertical MOSFET concept using selective epitaxial growth by low pressure chemical vapor deposition is proposed and the ®rst p-channel device characteristics measured are described. In contrast to ... [more ▼]

A novel vertical MOSFET concept using selective epitaxial growth by low pressure chemical vapor deposition is proposed and the ®rst p-channel device characteristics measured are described. In contrast to other MOS technologies, the gate oxide is deposited before epitaxy, and therefore it exists before the channel region is grown. Compared to planar layouts, the vertical layout increases the packing density without the use of advanced lithography; the extent of the increase depends on application. Compared to other vertical transistors, this concept reduces overlap capacitance and o ers the possibility of three-dimensional integration. Vertical p channel MOSFETs with a channel length LG down to 130 nm and a gate oxide thickness dox down to 12 nm have been fabricated and yield a transconductance of 100 mS mm-1. [less ▲]

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See detailExistence of An Intrinsic Glass Transition In A Silicon Rubber: Hypersonic Versus Calorimetric Properties
Krüger, Jan-Kristian UL; Mesquida, P.; Baller, Jörg UL

in Physical Review. B, Condensed Matter and Materials Physics (1999), 60(14), 10037-10041

Time-domain temperature-modulated differential scanning calorimetry and high-performance Brillouin spectroscopy have been used as experimental techniques in order to investigate the effect of the thermal ... [more ▼]

Time-domain temperature-modulated differential scanning calorimetry and high-performance Brillouin spectroscopy have been used as experimental techniques in order to investigate the effect of the thermal glass transition on the specific heat as well as on the acoustic properties, quantities which are intimately related by thermodynamics, but measured at completely different frequencies. Using a siloxane as a model substance, we demonstrate the efficiency of hypersonic relaxations until thermal freezing of the material. Introducing the optoacoustic dispersion function as a sensitive measure for structural relaxations, we show that the high-frequency α relaxations are truncated by the thermal glass transition instead of dying out at much higher temperatures. Moreover, the extrapolated static compliance of the rubbery state goes to zero close to but below the thermal glass transition temperature Tg, indicating the existence of an acoustic instability which is reminiscent of the so-called Kauzmann paradox. [less ▲]

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See detail«Semiotica del gusto»
Roelens, Nathalie UL

in Relaciones (Revista al tema del hombre) (1999)

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See detailUmweltschutz in Frankreich - eine Stille Revolution im Zeichen Europas?
Schulz, Christian UL

in Geographische Rundschau (1999)

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See detailRadical intersubjectivity. Reflections on the "different" foundation of education.
Biesta, Gert UL

in Studies in Philosophy & Education (1999), 18(4), 203-220

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See detailOn the Influence of Nano-Scaling on the Glass Transition of Molecular Liquids
Krüger, Jan-Kristian UL; Holtwick, R.; le Coutre, Andre et al

in Nanostructured Materials (1999), 12(1), 519-522

The nature of the glass transition is still a matter of debate. We used temperature modulated DSC (TMDSC) and Brillouin spectroscopy ( BS ) to investigate the freezing behaviour of canonical glasses ... [more ▼]

The nature of the glass transition is still a matter of debate. We used temperature modulated DSC (TMDSC) and Brillouin spectroscopy ( BS ) to investigate the freezing behaviour of canonical glasses ( salol and di-n-butyl-phtalate (DBP)) confined to controlled pore glasses (CPG) with pore diameters between 2.5 and 20 nm. The temperature behaviour of the heat capacity of the composite system deviates from the bulk fluid properties and we interpret the remaining kink-like anomaly at Tg as a static glass transition. In smaller pores Tg is only slightly shifted to lower temperatures. This operative Tg is in good agreement with sound velocity data showing a sharp kink at Tg. The working hypothesis of the existence of a static glass transition is supported by the fact that the -relaxation process disappears with decreasing pore diameter. [less ▲]

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See detailElectrooptic and dielectric spectroscopy measurements of binary chiral-dopant antiferroelectric mixtures
Parghi, D. D.; Lagerwall, Jan UL; Heppke, Gerd

in Molecular Crystals and Liquid Crystals (1999), 351

Recent examinations on binary chiral-dopant antiferroelectric liquid crystalline mixtures revealed an unusual switching behaviour. In order to investigate the switching processes that take place in the ... [more ▼]

Recent examinations on binary chiral-dopant antiferroelectric liquid crystalline mixtures revealed an unusual switching behaviour. In order to investigate the switching processes that take place in the mixtures, both in the bulk and as influenced by surfaces, further electrooptic and dielec- tric spectroscopy studies have been carried out on two model binary mix- tures in the induced SmA*, SmC* and SmCA* phases. The dielectric spectra feature the different modes typical for these phases, but of varying purity, indicating a more complex phase behaviour than expected. The electrooptic behaviour in the antiferroelectric phase varied from clearly antiferroelectric to near hysteresis-free switching directly between ferro- electric states. We conclude that the phase sequence, and consequently switching behaviour, is a function of both the type of dopant used and of the strength of the surface interactions (cell thickness). In thin cells syn- clinic (ferroelectric) ordering appears to be favoured. [less ▲]

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See detail«Les masques de la mémoire chez Michel Leiris: de l'iconographie à la tauromachie»
Roelens, Nathalie UL

in Texte (numéro spécial "Mnémotechnologies. Texte et mémoire") (1999)

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See detailMutation in the betaA3/A1-crystallin encoding gene Cryba1 causes a dominant cataract in the mouse.
Graw, J.; Jung, M.; Loster, J. et al

in Genomics (1999), 62(1), 67-73

During the mouse ENU mutagenesis screen, mice were tested for the occurrence of dominant cataracts. One particular mutant was discovered as a progressive opacity (Po). Heterozygotes show opacification of ... [more ▼]

During the mouse ENU mutagenesis screen, mice were tested for the occurrence of dominant cataracts. One particular mutant was discovered as a progressive opacity (Po). Heterozygotes show opacification of a superficial layer of the fetal nucleus, which progresses and finally forms a nuclear opacity. Since the homozygotes have already developed the total cataract at eye opening, the mode of inheritance is semidominant. Linkage analysis was performed using a set of genome-wide microsatellite markers. The mutation was mapped to chromosome 11 distal of the marker D11Mit242 (9.3 +/- 4.4 cM) and proximal to D11Mit36 (2.3 +/- 2.3 cM). This position makes the betaA3/A1-crystallin encoding gene Cryba1 an excellent candidate gene. Mouse Cryba1 was amplified from lens mRNA. Sequence analysis revealed a mutation of a T to an A at the second base of exon 6, leading to an exchange of Trp by Arg. Computer analysis predicts that the fourth Greek key motif of the affected betaA3/A1-crystallin will not be formed. Moreover, the mutation leads also to an additional splicing signal, to the skipping of the first 3 bp of exon 6, and finally to the deletion of the Trp residue. Both types of mRNA are present in the homozygous mutant lenses. The mutation will be referred to as Cryba1(po1). This particular mouse mutation provides an excellent animal model for a human congenital zonular cataract with suture opacities, which is caused by a mutation in the homologous gene. [less ▲]

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See detailSeasonal Motion in the Annapolis, Maryland GPS Monument
Schenewerk, M.; van Dam, Tonie UL; Nerem, Steven R.

in GPS Solutions (1999), 2(3), 41-49

The permanent GPS tracking site at Annapolis, MD shows a 7-mm seasonal signal primarily in its horizontal position. It is suggested that thermal expansion of the pier on which the antenna rests is the ... [more ▼]

The permanent GPS tracking site at Annapolis, MD shows a 7-mm seasonal signal primarily in its horizontal position. It is suggested that thermal expansion of the pier on which the antenna rests is the source of this motion. A simple numerical model of the pier reproduces the observed motion of the GPS antenna, lending credence to this hypothesis. Although adding an additional level of complexity, this motion is predictable and the site retains it s value for high precision monitoring. Although the arrangement of this GPS site it somewhat uncommon, these results emphasize the importance of the underlying antenna monumentation when measuring crustal motions. [less ▲]

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See detailHypoglycemia during intensified insulin therapy of young children
De Beaufort, Carine UL

in Journal of Pediatric Endocrinology and Metabolism (1998), 11(1), 153-158

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See detailPET study of human voluntary saccadic eye movements in darkness: Effect of task repetition on the activation pattern
Dejardin, S; Dubois, S; Bodart, M. J et al

in European Journal of Neuroscience (1998), 10

Using H2(15)O 3D Positron Emission Tomography (PET), regional cerebral blood flow (rCBF) was measured in six human subjects under two different conditions: at rest and while performing self-paced ... [more ▼]

Using H2(15)O 3D Positron Emission Tomography (PET), regional cerebral blood flow (rCBF) was measured in six human subjects under two different conditions: at rest and while performing self-paced horizontal saccadic eye movements in darkness. These two conditions were repeated four times each. First, the comparison between the four saccadic and four resting conditions was investigated in a group and a single subject analysis. Saccades elicited bilateral rCBF increases in the medial part of the superior frontal gyrus (supplementary eye field), precentral gyrus (frontal eye field), superior parietal lobule, anterior medial part of the occipital lobe involving striate and extrastriate cortex (lingual gyrus and cuneus), and in the right inferior parietal lobule. At the subcortical level, activations were found in the left putamen. These results mainly replicate previous PET findings on saccadic control. Second, the interaction between the experimental conditions and their repetition was examined. When activations throughout repetition of the same saccadic task are compared, the supplementary eye fields show a progressive increase of activation. On the contrary, the activation in the cerebellum, left superior parietal lobule and left occipital cortex progressively decreases during the scanning session. Given the existence of such an interaction, the pattern of activations must be interpreted as a function of task repetition. This may be a factor explaining some apparent mismatch between different studies. [less ▲]

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See detailRaumentwicklung und Logistik. Zwischen "space of flows" und Zielen der Nachhaltigkeit.
Hesse, Markus UL

in Raumforschung und Raumordnung (1998), (2/3), 125-135

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See detailOverexpression of the sarcolemmal calcium pump in the myocardium of transgenic rats.
Hammes, A.; Oberdorf-Maass, S.; Rother, T. et al

in Circulation Research (1998), 83(9), 877-88

The plasma membrane calmodulin-dependent calcium ATPase (PMCA) is a calcium-extruding enzyme controlling Ca2+ homeostasis in nonexcitable cells. However, its function in the myocardium is unclear because ... [more ▼]

The plasma membrane calmodulin-dependent calcium ATPase (PMCA) is a calcium-extruding enzyme controlling Ca2+ homeostasis in nonexcitable cells. However, its function in the myocardium is unclear because of the presence of the Na+/Ca2+ exchanger. We approached the question of the physiological function of the calcium pump using a transgenic "gain of function" model. Transgenic rat lines carrying the human PMCA 4 cDNA under control of the ventricle-specific myosin light chain-2 promoter were established, and expression in the myocardium was ascertained at the mRNA, protein, and functional levels. In vivo hemodynamic measurements in adult homozygous animals showed no differences in baseline and increased cardiac performance recruited by volume overload compared with controls. No differences between transgenic and control cardiomyocytes were found in patch clamp voltage dependence, activation/inactivation behavior of the L-type Ca2+ current, or fast [Ca2+]i transients (assessed by the Fura-2 method). To test whether the PMCA might be involved in processes other than beat-to-beat regulation of contraction/relaxation, we compared growth processes of neonatal transgenic and control cardiomyocytes. A 1.6- and 2.3-fold higher synthesis rate of total protein was seen in cells from transgenic animals compared with controls on incubation with 2% FCS for 24 hours and 36 hours, respectively. An effect of similar magnitude was observed using 20 micromol/L phenylephrine. A 1.4-fold- and 2.0-fold-higher protein synthesis peak was seen in PMCA-overexpressing cardiomyocytes after stimulation with isoproterenol for 12 hours and 24 hours, respectively. Because pivotal parts of the alpha- and beta-adrenergic signal transduction pathways recently have been localized to caveolae, we tested the hypothesis that the PMCA might alter the amplitude of alpha- and beta-adrenergic growth signals by virtue of its localization in caveolae. Biochemical as well as immunocytochemical studies suggested that the PMCA in large part was colocalized with caveolin 3 in caveolae of cardiomyocytes. These results indicate that the sarcolemmal Ca2+-pump has little relevance for beat-to-beat regulation of contraction/relaxation in adult animals but likely plays a role in regulating myocardial growth, possibly through modulation of caveolar signal transduction. [less ▲]

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See detailBildung - ein schulpädagogischer Begriff?
Tröhler, Daniel UL

in Infos und Akzente (1998), (1), 10-17

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See detailBespreking van W. Pols et al, Opvoeding zoals het is.
Biesta, Gert UL

in Comenius (1998), 18(2), 202-205

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See detailMead, Intersubjectivity, and Education: The Early Writings.
Biesta, Gert UL

in Studies in Philosophy & Education (1998), 17

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See detailComplete lifts of connections and stochastic Jacobi fields
Arnaudon, Marc; Thalmaier, Anton UL

in Journal de Mathématiques Pures et Appliquées (1998), 77(3), 283-315

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See detailSay you want a revolution... Suggestions for the impossibile future of critical pedagogy.
Biesta, Gert UL

in Educational Theory (1998), 48(4), 499-510

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See detailDie Emanzipation des Lëtzebuergeschen aus dem Gefüge der deutschen Mundarten
Gilles, Peter UL

in Zeitschrift für Deutsche Philologie (1998), (117), 20-35

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See detailInterleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
Heinrich, P. C.; Behrmann, Iris UL; Müller-Newen, G. et al

in Biochemical Journal (1998), 334 (Pt 2)

The family of cytokines signalling through the common receptor subunit gp130 comprises interleukin (IL)-6, IL-11, leukaemia inhibitory factor, oncostatin M, ciliary neurotrophic factor and cardiotrophin-1 ... [more ▼]

The family of cytokines signalling through the common receptor subunit gp130 comprises interleukin (IL)-6, IL-11, leukaemia inhibitory factor, oncostatin M, ciliary neurotrophic factor and cardiotrophin-1. These so-called IL-6-type cytokines play an important role in the regulation of complex cellular processes such as gene activation, proliferation and differentiation. The current knowledge on the signal-transduction mechanisms of these cytokines from the plasma membrane to the nucleus is reviewed. In particular, we focus on the assembly of receptor complexes after ligand binding, the activation of receptor-associated kinases of the Janus family, and the recruitment and phosphorylation of transcription factors of the STAT family, which dimerize, translocate to the nucleus, and bind to enhancer elements of respective target genes leading to transcriptional activation. The important players in the signalling pathway, namely the cytokines and the receptor components, the Janus kinases Jak1, Jak2 and Tyk2, the signal transducers and activators of transcription STAT1 and STAT3 and the tyrosine phosphatase SHP2 [SH2 (Src homology 2) domain-containing tyrosine phosphatase] are introduced and their structural/functional properties are discussed. Furthermore, we review various mechanisms involved in the termination of the IL-6-type cytokine signalling, namely the action of tyrosine phosphatases, proteasome, Jak kinase inhibitors SOCS (suppressor of cytokine signalling), protein inhibitors of activated STATs (PIAS), and internalization of the cytokine receptors via gp130. Although all IL-6-type cytokines signal through the gp130/Jak/STAT pathway, the comparison of their physiological properties shows that they elicit not only similar, but also distinct, biological responses. This is reflected in the different phenotypes of IL-6-type-cytokine knock-out animals. [less ▲]

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See detailOptoelectronic D.C. and R.F. behavior of InP/InGaAs Based HEMTs
Marso, Michel UL; Horstmann, M.; Hardtdegen, H. et al

in Solid-State Electronics (1998), 42(1998), 197-200

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See detailEditorial
Tröhler, Daniel UL

in Neue Pestalozzi-Blätter (1998), 4(1), 1-1

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See detailLe pouvoir réglementaire des ministres après l'arrêt de la Cour Constitutionnelle du 6 mars 1998, note sous Cour Constitutionnelle 6 mars 1998
Ravarani, Georges UL

in Pasicrisie Luxembourgeoise: Recueil Trimestriel de la Jurisprudence Luxembourgeoise (1998), 30

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See detailDirect clustering of a two-mode binary data-matrix
Krolak-Schwerdt, Sabine UL; Orlik, Peter

in Universität des Saarlandes: Arbeiten der Fachrichtung Psychologie (1998), 186

In this paper a discrete, categorical model is proposed for two-:­ mode data matrices with binary entries Xij E {0, 1}. The method operates directly upon a raw input (objects by attributes) data array by ... [more ▼]

In this paper a discrete, categorical model is proposed for two-:­ mode data matrices with binary entries Xij E {0, 1}. The method operates directly upon a raw input (objects by attributes) data array by determining two-mode submatrices whose entries entirely have values x;j = 1. In addition, different submatrices are required to have a minimum set of objectattribute- pairs in common. Objects and attributes are classified simultaneously in a number ofjoint clusters. The method may be characterized as a non-hierarchical clustering procedure and in its model function to predict the data it is similar to Boolean factor analy􀢛is. Basically, the proposed method dubbed ' GRIDPAT' (for 'PATtern analysis of GRIDs') was developped for the structural representation of self concept data. Its relations to basic notions of Formal Concept Analysis and blockmodeling are discussed. An illustrative application of the approach is provided. [less ▲]

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See detailModeling environmental loading effects, Invited, Proceedings EGGS, Ed. H.-P. Plag and S. Zerbini
van Dam, Tonie UL; Wahr, John

in Physics and chemistry of the earth (1998), 23

Temporal variations in the geographic distribution of atmospheric, hydrologic and oceanic mass load and deform the surface of the Earth. In many instances, the deformation is large enough to be detected ... [more ▼]

Temporal variations in the geographic distribution of atmospheric, hydrologic and oceanic mass load and deform the surface of the Earth. In many instances, the deformation is large enough to be detected with space based geodetic techniques as well as with terrestrial gravity observations. For example, atmospheric loading induced crustal deformations on the order of 20 mm are possible at high latitudes with accompanying changes in gravity of 6 μGals. Non-tidal ocean loading effects can typically cause 5 mm (2 mm root-mean-square, RMS) in vertical positioning at coastal geodetic sites with displacements of up to 10 mm possible. Deformation associated gravity changes are usually on the order of 2-3 μGals, however peak-to-peak changes of 5 μGals are also predicted. The effects of regional ground water variations on geodetic measurements are less well known. Model results indicate that annual changes in gravity and vertical positioning can be as large as 2 μGals and 5 mm for sites where there is significant annual snowfall. We present a review of work done to date to address these issues. [less ▲]

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See detailCovariance Matching Estimation Techniques for Array Signal Processing Applications
Ottersten, Björn UL; Stoica, Petre; Roy, R.

in Digital Signal Processing (1998), 8

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See detailSea-level rise studied in Chesapeake Bay as wetlands loss continues
Nerem, R. S.; Schenewerk, M.; van Dam, Tonie UL

in Earth in Space (1998), 10(12), 156-157

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See detailOscillations in the magnetoconductance autocorrelation function for ballistic microstructures
Tang, J. Z.; Wirtz, Ludger UL; Burgdorfer, J. et al

in Physical Review. B : Condensed Matter (1998), 57(16), 9875-9878

We present a comparison between experiment and theory for the magnetoconductance autocorrelation function C(Delta B) for transport through a stadium-shaped ballistic microstructure. The correlation ... [more ▼]

We present a comparison between experiment and theory for the magnetoconductance autocorrelation function C(Delta B) for transport through a stadium-shaped ballistic microstructure. The correlation function displays damped oscillations which can be traced to the quantum interference between bundles of short trajectories. We present two different semiclassical calculations applicable for large and small mode numbers of the quantum wire, respectively. Good agreement is found with experimental data taken at relatively low mode numbers. [S0163-1829(98)03316-5]. [less ▲]

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See detailExtraposition of gerundial and infinitival subject: Factors and figures
Deroey, Katrien UL

in Studia Germanica Gandensia (1998), 44

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See detailThe M2 muscarinic receptor antagonist methoctramine activates mast cells via pertussis toxin-sensitive G proteins
Chahdi, A.; Daeffler, L.; Bueb, Jean-Luc UL et al

in Naunyn-Schmiedeberg's Archives of Pharmacology (1998), 357(4), 357-62

Methoctramine, a selective M2 muscarinic cholinergic receptor antagonist, has been reported to activate phosphoinositide breakdown at high concentrations. Its polyamine structure suggests a putative ... [more ▼]

Methoctramine, a selective M2 muscarinic cholinergic receptor antagonist, has been reported to activate phosphoinositide breakdown at high concentrations. Its polyamine structure suggests a putative activation of guanine nucleotide-binding proteins (G proteins). Incubation of methoctramine with rat peritoneal mast cells resulted in a dose-dependent noncytotoxic histamine release, with an EC50 of 20 microM and a maximum effect at 1 mM. Atropine, pirenzepine and HHSiD neither inhibited methoctramine-induced histamine release nor stimulated histamine release. Histamine release and inositol phosphates generation induced by methoctramine were both inhibited by pertussis toxin pretreatment. Benzalkonium chloride, a selective inhibitor of histamine secretion induced by basic secretagogues, inhibited the secretory response to methoctramine. [p-Glu5, D-Trp7,9,l0]-SPs5-11 (GPAnt-2), a well-characterized antagonist of G proteins, blocked the methoctramine-induced histamine release when the antagonist was allowed to reach its intracellular target by streptolysin O-permeabilization. The response to methoctramine was prevented by the hydrolysis of sialic acid residues of the cell surface by neuraminidase. The response of mast cells was restored by permeabilization of the plasma membrane. These results demonstrate that methoctramine, following its entry into the cell and the involvement of pertussis toxin-sensitive G proteins, activates phosphoinositide hydrolysis leading to mast cell exocytosis. [less ▲]

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See detailChesapeake Bay subsidence monitored as wetlands loss continues
Nerem, R. S.; van Dam, Tonie UL; Schenewerk, M.

in EOS (1998), 79

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See detailReview of Peter McLaren, Revolutionary Multiculturalism.
Biesta, Gert UL

in Educational Studies (1998), 29(3), 298-302

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See detailBefindlichkeitsregulation durch temporale und soziale Vergleichsprozesse im Alter?
Filipp, Sigrun-Heide; Ferring, Dieter UL

in Zeitschrift für Klinische Psychologie, Psychopathologie und Psychotherapie (1998), 27(2)

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See detailMalliavin Calculus with time dependent coefficients applied to a class of stochastic differential equations
Schiltz, Jang UL

in Stochastic Analysis & Applications (1998), 16(6), 1073-1100

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See detailEditorial
Tröhler, Daniel UL

in Neue Pestalozzi-Blätter (1998), 4(2), 1-1

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See detailEuropean Community Criminal Law
Ligeti, Katalin UL

in Acta Juridica Hungarica (1998)

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See detailReview of: J. Thornborrow & S. Wareing. Patterns in Language
Weber, Jean-Jacques UL

in Functions of Language (1998), 5

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See detailThe HSSP database of protein structure sequence alignments and family profiles
Dodge, C.; Schneider, Reinhard UL; Sander, C.

in Nucleic Acids Research (1998), 26(1), 313-315

HSSP (http://www.sander.embl-ebi.ac.uk/hssp/) is a derived database merging structure (3-D) and sequence (1-D) information, For each protein of known 3D structure from the Protein Data Bank (PDB), we ... [more ▼]

HSSP (http://www.sander.embl-ebi.ac.uk/hssp/) is a derived database merging structure (3-D) and sequence (1-D) information, For each protein of known 3D structure from the Protein Data Bank (PDB), we provide a multiple sequence alignment of putative homologues and a sequence profile characteristic of the protein family, centered on the known structure. The list of homologues is the result of an iterative database search in SWISS-PROT using a position-weighted dynamic programming method for sequence profile alignment (MaxHom). The database is updated frequently, The listed putative homologues are very likely to have the same 3D structure as the PDB protein to which they have been aligned. As a result, the database not only provides aligned sequence families, but also implies secondary and tertiary structures covering 33% of all sequences in SWISS-PROT. [less ▲]

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See detailA Statistical Approach to Subspace Based Blind Identification
Kristensson, Martin; Ottersten, Björn UL

in IEEE Transactions on Signal Processing (1998), 46(6), 16121623

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See detailReliability and Validity of the Southern California Ordinal Scales of Development for a Sample of Young Children with Disabilities
Pit-Ten Cate, Ineke UL; Miller, A. Cate; Rosen, Carol et al

in Journal of Psychoeducational Assessment (1998), 16(1), 4-14

The primary purpose of this study was to inves­tigate the reliability and validity of the Southern California Ordinal Scales of Development (SCOSD) . The SCOSD is a criterion-referenced test that assesses ... [more ▼]

The primary purpose of this study was to inves­tigate the reliability and validity of the Southern California Ordinal Scales of Development (SCOSD) . The SCOSD is a criterion-referenced test that assesses six domains of development and was designed for use with children with disabilities. Results found that the SCOSD alpha internal consistency coefficients ranged from .94 to .98; percent agreement between raters ranged from 85% to 100%; and inter­ rater correlations ranged from .96 to .99. Strong intercorrelations were found between the SCOSD and standardized domain-specific instruments (.65 to .92), providing evidence of concurrent validity. The secondary purpose was to investigate patterns of development across domains of the children's functioning. As expected, results revealed a hierarchy of skill development, with the children showing relatively less development in gross-motor skills and practical abilities. [less ▲]

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See detail[Compression therapy of a ruptured spurious aneurysm].
Beer, M.; Tschammler, A.; Wittenberg, G. et al

in RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin (1998), 168(3), 291-3

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