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See detailFusionierte lösliche Rezeptoren als hochaktive Zytokin-Inhibitoren.
Müller-Newen, Gerhard; Haan, Serge UL; Heinrich, Peter C.

in Biospektrum (2003), Sonderausgabe(9. Jahrgang), 480-483

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See detailBook review of : V. PRESS, Das Alte Reich. Ausgewählte Aufsätze, 1997
Weis, Monique UL

in Revue Belge de Philologie et d'Histoire (2003), 81

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See detailConstructing Disability and Social Inequality Early in the Life Course
Powell, Justin J W UL

in Disability Studies Quarterly (2003), 23(2),

oining life course and educational stratification research with disability studies' complimentary emphasis on structure and disabling barriers enables a more complete analysis of the experiences and life ... [more ▼]

oining life course and educational stratification research with disability studies' complimentary emphasis on structure and disabling barriers enables a more complete analysis of the experiences and life chances of primary and secondary school students who are classified disabled. Because the processes that affect life course phases and transitions, as well as individual opportunities, identities, and attainments are cumulative, analysis of early differentiation is necessary to understand how (special) education legitimates and generates social inequality. Universal compulsory education led schools to develop a variety of sorting mechanisms. Especially during the resulting transitions within an educational system's learning opportunity structures, special educational needs are identified, labelled and categorical boundaries drawn around dis/ability altering individuals' trajectories. By stigmatizing, separating, and segregating students, special education institutions in Germany and the United States construct social inequality early in the life course. [less ▲]

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See detailTowards computerized analysis of folksong
Sagrillo, Damien UL

in Muzyka, XLVIII (2003), 1

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See detailBeta3 integrins: major therapeutic targets of the near future.
Schaffner-Reckinger, Elisabeth UL

in Bulletin de la Société des Sciences Médicales du Grand-Duché de Luxembourg (2003), (1), 23-34

Integrins are major cell adhesion receptors which assume two important functions: first they act as anchoring molecules allowing firm cellular attachment to the extracellular matrix, and second they work ... [more ▼]

Integrins are major cell adhesion receptors which assume two important functions: first they act as anchoring molecules allowing firm cellular attachment to the extracellular matrix, and second they work as signalling receptors being able to transduce signals in both directions (outside-in and inside-out) through the plasma membrane. Their biological importance is determined by their involvement in many physiological phenomena. Furthermore, their implication in various diseases and their accessibility to drugs make them interesting therapeutic targets. [less ▲]

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See detailDie Bedeutung der Philosophie für einen Theologen
Weber, Jean-Marie UL

in Nos Cahiers (2003), 1

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See detailCorruption and Related Crimes in International Business Activities, Hungarian National Report
Ligeti, Katalin UL

in Revue Internationale de Droit Pénal (2003)

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See detailDie Elektronische Hauptversammlung
Zetzsche, Dirk Andreas UL

in Deutsche Gesellschaft für Recht und Informatik, E-Government: Regierungshandeln in der Informationsgesellschaft, Jahresband 2002 (2003)

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See detailKonzepte und Leitthemen einer "ökologischen Modernisierung" der Wirtschaftsgeographie.
Braun, Boris; Schulz, Christian UL; Soyez, Dietrich UL

in Zeitschrift für Wirtschaftsgeographie (2003), 47

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See detailEthik ohne Theorie. Zum Problem der Moralbegründung
Heidemann, Dietmar UL

in Allgemeine Zeitschrift für Philosophie (2003), 28

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See detailPISA und Demokratie
Tröhler, Daniel UL

in PH Akzente (2003), 10(2), 24-25

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See detailAdaptive tests of qualitative hypotheses
Baraud, Yannick UL; Huet, Sylvie; Laurent, Béatrice

in ESAIM: Probability and Statistics (2003), 7

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See detailRezension: Fred Karl (Hrsg.): Sozial- und Verhaltenswissenschaftliche Gerontologie
Karl, Ute UL

in Sozialwissenschaftliche Literatur Rundschau (2003), 26(47), 118-120

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See detailLes interventions de Philippe de Marnix aux assemblées impériales. Augsbourg 1566 – Spire 1570 – Worms 1578
Weis, Monique UL

in Bulletin de la Société royale d’histoire du protestantisme belge (2003), 132

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See detailTranscoding zeros within complex numerals.
Grana, Alessia; Lochy, Aliette UL; Girelli, Luisa et al

in Neuropsychologia (2003), 41(12), 1611-8

This paper describes a patient (LD) showing a selective syntactic deficit in the production of Arabic numerals. Unlike in previously reported cases, LD's syntactic difficulties result in deletions rather ... [more ▼]

This paper describes a patient (LD) showing a selective syntactic deficit in the production of Arabic numerals. Unlike in previously reported cases, LD's syntactic difficulties result in deletions rather than insertions of zeros, with a reduction of the number magnitude. The pattern of errors highlighted a distinction between "lexical zeros", i.e. the zeros in tens, that are semantically derived, and "syntactic zeros" that are syntactically produced as the result of specific production rules. In LD, only syntactic zeros were affected. Furthermore, the processing of numerals with final zeros was found to be easier than the processing of numerals with internal zeros. This pattern of errors is compatible with the lexical-semantic model of Power and Dal Martello. In this model, in fact, lexical zeros originate from a numerical concept, while syntactic zeros originate from a concatenation operation, plus an overwriting operation leaving one or more intermediary zeros. Thus, lexical zeros may be easier to manipulate than syntactic zeros that merely represent a null quantity associated to a specific power of 10. [less ▲]

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See detailRational promoter selection for gene transfer into cardiac cells.
Maass, Alexander; Langer, Stephen J.; Oberdorf-Maass, Silke et al

in Journal of Molecular and Cellular Cardiology (2003), 35(7), 823-31

Cardiomyocytes (CMCs) are extremely difficult to transfect with non-viral techniques, but they are efficiently infected by adenoviruses. The most commonly used promoters to drive protein expression in ... [more ▼]

Cardiomyocytes (CMCs) are extremely difficult to transfect with non-viral techniques, but they are efficiently infected by adenoviruses. The most commonly used promoters to drive protein expression in cardiac myocytes are of viral origin, since they are believed to be constitutively active and minimally regulated by physiological or pharmacological challenge of cells. In recombinant adenoviruses, we systematically compared three different promoters: the cytomegalovirus (CMV), the Rous sarcoma virus (RSV), and a synthetic promoter with three MEF2 transcription factor-binding sites upstream of the heat-shock protein 68 minimal promoter. We determined their basal activity in primary cardiac cells as well as their possible stimulation by commonly used agonists. The CMV promoter was activated up to 60-fold by the phorbol ester phorbol myristate acetate (PMA) and/or forskolin in neonatal rat CMCs and cardiac fibroblasts. Primary adult rat CMCs had higher basal expression from the CMV promoter that was not activated by PMA or forskolin. The RSV promoter was less affected by agonists and was more active in cardiac myocytes compared to cardiac fibroblasts. The MEF2-responsive promoter showed high basal expression in both myocytes and fibroblasts, and minimal induction by phorbol esters and forskolin. The relevance of reporter gene induction was confirmed with a contractile protein, troponin T (TnT). The CMV promoter driving TnT could be induced more than 15-fold with phenylephrine or forskolin to replace the endogenous protein almost to completion at a multiplicity of infection of 10. These results suggest the following use of the tested promoters: an inducible system (CMV), a myocyte-enriched system (RSV), or a stable control system (MEF2). [less ▲]

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See detailGefühl und Begründung. Humes dreidimensionaler Überzeugungsbegriff
Heidemann, Dietmar UL

in Kritisches Jahrbuch der Philosophie (2003), 8

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See detailDomain formation and long-range spin disorder in Vitroperm
Michels, Andreas UL; Viswanath, R. N.; Weissmüller, J.

in Europhysics Letters (2003), 64

We present a study of the magnetic-field dependence of the small-angle neutron scattering of the nanocrystalline soft magnet Vitroperm (Fe73Si16B7Nb3Cu1), which was treated so as to exhibit a macroscopic ... [more ▼]

We present a study of the magnetic-field dependence of the small-angle neutron scattering of the nanocrystalline soft magnet Vitroperm (Fe73Si16B7Nb3Cu1), which was treated so as to exhibit a macroscopic magnetic anisotropy. We show how the field dependences of i) the radial average of the scattering cross-section dΣ/dΩ and ii) the variation of dΣ/dΩ as a function of the orientation of the scattering vector can be analysed to supply separately information on the orientation of the net magnetisation of the domains and on the internal spin disorder within the domains. As the applied magnetic field is decreased starting from saturation, we find that two processes occur independently: the formation of a domain structure with the net magnetisation of the domains aligned along the macroscopic easy axis and the increase in magnitude of static, nanometer-scale fluctuations of the spin orientation. [less ▲]

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See detailA Bismut type formula for the Hessian of heat semigroups
Arnaudon, Marc; Plank, Holger; Thalmaier, Anton UL

in Comptes Rendus. Mathématique (2003), 336(8), 661-666

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See detailInvestigation of buffer traps in an AlGaN/GaN/Si high electron mobility transistor by backgating current deep level transient spectroscopy
Marso, Michel UL; Wolter, M.; Javorka, P. et al

in Applied Physics Letters (2003), 82

The influence of a substrate voltage on the dc characteristics of an AlGaN/GaN high electron mobility transistor ~HEMT! on silicon ~111! substrate is profited to investigate traps that are located between ... [more ▼]

The influence of a substrate voltage on the dc characteristics of an AlGaN/GaN high electron mobility transistor ~HEMT! on silicon ~111! substrate is profited to investigate traps that are located between the substrate and the two-dimensional electron gas channel. The transient of the drain current after applying a negative substrate voltage is evaluated in the temperature range from 30 to 100 °C. With this method, known as backgating current deep level transient spectroscopy, majority carrier traps with activation energy of 200 meV as well as minority carrier traps at 370 meV are identified. The experiments are performed on completed HEMTs, allowing the investigation of the influence of device fabrication technology. [less ▲]

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See detailGiant cavernoma of the brain stem: value of delayed MR imaging after contrast injection.
Thiex, R.; Krüger, Rejko UL; Friese, S. et al

in European radiology (2003), 13 Suppl 6

Cavernous angiomas are vascular malformations composed of slowly perfused, sinusoidal vessels which can be located in any part of the central nervous system. Whereas diagnosis is mostly straightforward in ... [more ▼]

Cavernous angiomas are vascular malformations composed of slowly perfused, sinusoidal vessels which can be located in any part of the central nervous system. Whereas diagnosis is mostly straightforward in typical cases, some lesions may present in unusual locations or with unusual imaging characteristics. Because of the slow perfusion, contrast enhancement is not regarded as a characteristic imaging feature of cavernomas. We report a large brain stem cavernoma with signs of recent bleeding, in which the differential diagnosis against other mass lesions was facilitated by the demonstration of slow, but intense, contrast enhancement on MRI 1 h after contrast injection. We conclude that contrast enhancement in delayed images may contribute to a safe diagnosis of cavernous haemangiomas and should be performed in atypical cases. [less ▲]

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See detailNumerical error for SDE: asymptotic expansion and hyperdistributions
Malliavin, Paul; Thalmaier, Anton UL

in Comptes Rendus. Mathématique (2003), 336(10), 851-856

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See detailQuantum master equation for a system influencing its environment
Esposito, Massimiliano UL; Gaspard, P.

in Physical Review. E. (2003), 68(6),

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See detailOù travaillent les frontaliers?
Pigeron-Piroth, Isabelle UL; Casteels, Yvan

in Economie et Statistique (2003), 1

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See detailModulation of disease risk according to a cathepsin D / apolipoprotein E genotype in Parkinson's disease.
Schulte, T.; Bohringer, S.; Schols, L. et al

in Journal of Neural Transmission (2003), 110(7), 749-55

Aspartyl protease Cathepsin D (CTSD) has been suggested to play a role in the pathogenesis of sporadic Alzheimer's disease (AD) due to interference with protein degradation mechanisms. A C224T (A38V ... [more ▼]

Aspartyl protease Cathepsin D (CTSD) has been suggested to play a role in the pathogenesis of sporadic Alzheimer's disease (AD) due to interference with protein degradation mechanisms. A C224T (A38V) polymorphism in exon 2 of the CTSD gene is reported to be associated with an increased risk for AD. The partially overlapping pathology between AD and Parkinson's disease (PD) led us to investigate the role of this polymorphism in PD. Using association studies in 457 German PD patients and 340 controls we found no evidence for direct association between the CTSD genotype and PD. However, stratification for the apolipoprotein E (APOE) epsilon4 allele suggests a protective effect of the CTSD T-allele in PD (OR = 0.24, p = 0.002). Our findings suggest interference of CTSD and APOE polymorphisms in the pathogenesis of PD, in the sense of modulating disease risk. [less ▲]

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See detailInteraction of the plasma membrane Ca2+ pump 4b/CI with the Ca2+/calmodulin-dependent membrane-associated kinase CASK.
Schuh, Kai; Uldrijan, Stjepan; Gambaryan, Stepan et al

in The Journal of biological chemistry (2003), 278(11), 9778-83

Spatial and temporal regulation of intracellular Ca(2+) is a key event in many signaling pathways. Plasma membrane Ca(2+)-ATPases (PMCAs) are major regulators of Ca(2+) homeostasis and bind to PDZ (PSD-95 ... [more ▼]

Spatial and temporal regulation of intracellular Ca(2+) is a key event in many signaling pathways. Plasma membrane Ca(2+)-ATPases (PMCAs) are major regulators of Ca(2+) homeostasis and bind to PDZ (PSD-95/Dlg/ZO-1) domains via their C termini. Various membrane-associated guanylate kinase family members have been identified as interaction partners of PMCAs. In particular, SAP90/PSD95, PSD93/chapsyn-110, SAP97, and SAP102 all bind to the C-terminal tails of PMCA "b" splice variants. Additionally, it has been demonstrated that PMCA4b interacts with neuronal nitric-oxide synthase and that isoform 2b interacts with Na(+)/H(+) exchanger regulatory factor 2, both via a PDZ domain. CASK (calcium/calmodulin-dependent serine protein kinase) contains a calmodulin-dependent protein kinase-like domain followed by PDZ, SH3, and guanylate kinase-like domains. In adult brain CASK is located at neuronal synapses and interacts with various proteins, e.g. neurexin and Veli/LIN-7. In kidney it is localized to renal epithelia. Surprisingly, interaction with the Tbr-1 transcription factor, nuclear transport, binding to DNA T-elements (in a complex with Tbr-1), and transcriptional competence has been shown. Here we show that the C terminus of PMCA4b binds to CASK and that both proteins co-precipitate from brain and kidney tissue lysates. Immunofluorescence staining revealed co-expression of PMCA, CASK, and calbindin-d-28K in distal tubuli of rat kidney sections. To test if physical interaction of both proteins results in functional consequences we constructed a T-element-dependent reporter vector and investigated luciferase activity in HEK293 lysates, previously co-transfected with PMCA4b expression and control vectors. Expression of wild-type PMCA resulted in an 80% decrease in T-element-dependent transcriptional activity, whereas co-expression of a point-mutated PMCA, with nearly eliminated Ca(2+) pumping activity, had only a small influence on regulation of transcriptional activity. These results provide evidence of a new direct Ca(2+)-dependent link from the plasma membrane to the nucleus. [less ▲]

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See detailLe système scolaire luxembourgeois: Un système scolaire scolaire peu efficace malgré ou à cause de son caractère multilingue?
Portante, Dominique UL; Martin, Romain UL

in Cahiers du Service de Pédagogie Expérimentale (SPE) (2003), 15/16(4), 516-532

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See detailProcessus intra-familiaux et engagement parental : un modèle de compréhension du parcours scolaire
Poncelet, Débora UL

in Scientia Paedagogica Experimentalis (2003), 40(2), 201-222

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See detailAT2 receptor activation regulates myocardial eNOS expression via the calcineurin-NF-AT pathway.
Ritter, Oliver; Schuh, Kai; Brede, Marc et al

in FASEB Journal (2003), 17(2), 283-5

The role of AT2-receptors has recently been subject of considerable debate. We investigated the influence of AT2-stimulation/inhibition on myocardial endothelial NO-synthase (eNOS, NOS-III) promoter ... [more ▼]

The role of AT2-receptors has recently been subject of considerable debate. We investigated the influence of AT2-stimulation/inhibition on myocardial endothelial NO-synthase (eNOS, NOS-III) promoter activity and eNOS protein expression. Stimulation of rat cardiomyocytes with angiotensin II (AngII) increased eNOS protein expression 3.3-fold. This was blocked by Cyclosporin A (CsA). Inhibition of the AT1-receptor did not reduce AngII-mediated eNOS protein expression, whereas AT2 stimulation increased it 2.4-fold and AT2 inhibition suppressed it. The modulatory effects of the AT2-receptor on eNOS expression was confirmed in mice with a genetic deletion of the AT2-receptor (AT2-KO). In gel shift assays two putative NF-AT sites in a 1.6 kb eNOS promoter fragment showed NF-AT binding and a supershift by NF-AT2(-c1)-specific antibodies. Stimulation of transfected cells with AngII or specific AT2-receptor agonists resulted in a significant increase in eNOS promoter activity, which was blocked by CsA, MCIP1, and mutation of an upstream NF-AT site. CONCLUSION: 1) AngII-stimulation of the myocardium, both in vivo and in vitro, is accompanied by increased expression of eNOS. 2) This effect is mediated by the calcineurin pathway and is induced by the AT2-receptor. 3) These results define a calcineurin/NF-AT/eNOS pathway as downstream effector of AT2-receptor activation in the myocardium. [less ▲]

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See detailL2-gain of double integrators with saturation nonlinearity
Goncalves, Jorge UL

in IEEE Transactions on Automatic Control (2002), 47(12), 2063-2068

This note uses quadratic surface Lyapunov functions (SuLFs) to efficiently check if a double integrator in feedback with a saturation nonlinearity has L -gain less than > 0. We show that for many such ... [more ▼]

This note uses quadratic surface Lyapunov functions (SuLFs) to efficiently check if a double integrator in feedback with a saturation nonlinearity has L -gain less than > 0. We show that for many such systems, the L -gain is nonconservative in the sense that this is approximately equal to the lower bound obtained by replacing the saturation with a constant gain of 1. These results allow the use of classical analysis tools like -analysis or integral quadratic constraints to analyze systems with double integrators and saturations, including servo systems like some mechanical systems, satellites, hard disks, compact disk players, etc. [less ▲]

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See detailOn order invariant synthesizing functions
Marichal, Jean-Luc UL

in Journal of Mathematical Psychology (2002), 46(6), 661-676

This paper gives a description of the class of continuous functions that are comparison meaningful in the sense of measurement theory. When idempotency is assumed, this class reduces to the Boolean max ... [more ▼]

This paper gives a description of the class of continuous functions that are comparison meaningful in the sense of measurement theory. When idempotency is assumed, this class reduces to the Boolean max-min functions (lattice polynomials). In that case, continuity can be replaced by increasing monotonicity, provided the range of variables is open. The particular cases of order statistics and projection functions are also studied. [less ▲]

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See detailLa formación y promoción de las nuevas generaciones de científicos del deporte en Alemania
Bund, Andreas UL

in Educación física Chile (2002), 258

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See detailAspectos psicólogicos del entrenamiento de los deportistas juveniles
Bund, Andreas UL

in Educación Física y Deporte (2002), 22

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See detailMöglichkeiten der Drittmittelfinanzierung von Promotionen
Bund, Andreas UL

in Ze-phir : Informationen für den Sportwissenschaftlichen Nachwuchs (2002)

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See detailAbweichendes Verhalten
Willems, Helmut UL

in Kölner Zeitschrift für Soziologie und Sozialpsychologie (2002), 54(3), 590-591

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See detailAllpass Delay Chain-Based IIR PR Filterbank and Its Application to Multiple Description Subband Coding
Shankar, Bhavani UL; Makur, Anamitra

in IEEE Transactions on Signal Processing (2002), (4), 814-823

A class of infinite impulse response (IIR) perfect reconstruction (PR) filterbank is obtained with an allpass delay chain and finite impulse response (FIR) matrices at the analysis side. Such a ... [more ▼]

A class of infinite impulse response (IIR) perfect reconstruction (PR) filterbank is obtained with an allpass delay chain and finite impulse response (FIR) matrices at the analysis side. Such a formulation leads to a filterbank that can be optimized to any desired response. For a first-order allpass, the synthesis bank becomes FIR. Design examples showing warping of the frequency scale and filters with unequal passband widths are presented. The latter part of the work deals with designing a filterbank for a multiple description coding scenario. This is achieved in two parts: by obtaining the MMSE synthesis bank for a given analysis bank and channel state and by optimizing the analysis response to minimize the average distortion in the presence of channel erasures and quantization. The proposed IIR filterbank, as well as the well-known FIR paraunitary filterbank, are optimized for various channels, and their performances for the two-channel case have been compared with the derived optimal performance [less ▲]

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See detailEntropy of discrete Choquet capacities
Marichal, Jean-Luc UL

in European Journal of Operational Research (2002), 137(3), 612-624

We introduce a measure of entropy for any discrete Choquet capacity and we interpret it in the setting of aggregation by the Choquet integral.

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See detailPhotoionization spectroscopy of traps in AlGaN/GaN HEMTs
Wolter, M.; Javorka, P.; Marso, Michel UL et al

in Journal of Electronic Materials (2002), 31(12), 1321-1324

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See detailIn the Company of Men’: a reflexive tale of cultural organising in a small organisation
Fletcher, Denise Elaine UL

in Gender, Work and Organization (2002), 9(4), 65-76

A tale of fieldwork in a small organization is discussed in this article with a view to highlighting how social processes, cultural understandings and expressions of gender are produced during fieldwork ... [more ▼]

A tale of fieldwork in a small organization is discussed in this article with a view to highlighting how social processes, cultural understandings and expressions of gender are produced during fieldwork interaction. The tale is told reflexively and retrospectively, recording an ongoing conversation about fieldwork experience. Central to the tale is discussion of how the researcher is drawn into 'culture-making' within the organization and the ways in which fieldwork interaction creates a 'space' through which organizational members engage with, work through and realize workplace values. In this article there are multiple levels of reflection. At one level it is examined how the organizational-researcher role of 'emotional nurturer' was constructed during fieldwork. At the same time some cultural insights drawn from ethnographic inquiry and intensive interviewing within the small organization are presented. The analysis is also shaped by a further layer of post-fieldwork reflection and interpretation which draws in emotional issues and expressions of gender. It is argued that a close scrutiny of fieldwork roles is important to organizational research in that it makes explicit how the researcher-'native' interaction is central to the theorizing process and how the researcher can become a participant in organizational culture-making. [less ▲]

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See detailConditional inactivation of Sox9: a mouse model for campomelic dysplasia.
Kist, Ralf; Schrewe, Heinrich; Balling, Rudi UL et al

in Genesis (2002), 32(2), 121-3

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See detailArbeit zwischen Berufsarbeit und Demokratie
Tröhler, Daniel UL

in Unimagazin : die Zeitschrift der Universität Zürich (2002), 3

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See detailBeethoven, a mouse model for dominant, progressive hearing loss DFNA36.
Vreugde, Sarah; Erven, Alexandra; Kros, Corne J. et al

in Nature Genetics (2002), 30(3), 257-8

Despite recent progress in identifying genes underlying deafness, there are still relatively few mouse models of specific forms of human deafness. Here we describe the phenotype of the Beethoven (Bth ... [more ▼]

Despite recent progress in identifying genes underlying deafness, there are still relatively few mouse models of specific forms of human deafness. Here we describe the phenotype of the Beethoven (Bth) mouse mutant and a missense mutation in Tmc1 (transmembrane cochlear-expressed gene 1). Progressive hearing loss (DFNA36) and profound congenital deafness (DFNB7/B11) are caused by dominant and recessive mutations of the human ortholog, TMC1 (ref. 1), for which Bth and deafness (dn) are mouse models, respectively. [less ▲]

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See detailVergleichsprozesse in der Auseinandersetzung mit schweren körperlicher Erkrankungen
Filipp, Sigrun-Heide; Ferring, Dieter UL

in Psychotherapie im Dialog (2002), 3(1), 2-12

Das individuelle Bewaeltigungsverhalten im Umfeld einer Krebserkrankung wird analysiert. Dabei wird insbesondere auf die Rolle von temporalen und sozialen Vergleichsprozessen eingegangen. Diese beiden ... [more ▼]

Das individuelle Bewaeltigungsverhalten im Umfeld einer Krebserkrankung wird analysiert. Dabei wird insbesondere auf die Rolle von temporalen und sozialen Vergleichsprozessen eingegangen. Diese beiden Vergleichsprozesse stehen im Dienste der kognitiven Adaptation an die durch die Krankheit veraenderte Lebenssituation und lassen sich in einem uebergeordneten heuristischen Rahmenmodell des Bewaeltigungsprozesses als Versuche der Realitaetskonstruktion beschreiben. Ein solches Modell, in dem die individuelle Bewaeltigung in erster Linie als Prozess der Informationsverarbeitung konzeptualisiert wird, der dem Primat der Emotionsregulation und der Aufrechterhaltung der individuellen Handlungsfaehigkeit dienen soll, wird vorgestellt. [less ▲]

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See detailParkinson's disease: one biochemical pathway to fit all genes?
Krüger, Rejko UL; Eberhardt, Olaf; Riess, Olaf et al

in Trends in molecular medicine (2002), 8(5), 236-40

Although originally discounted, hereditary factors have emerged as the focus of research in Parkinson's disease (PD). Genetic studies have identified mutations in alpha-synuclein and ubiquitin C-terminal ... [more ▼]

Although originally discounted, hereditary factors have emerged as the focus of research in Parkinson's disease (PD). Genetic studies have identified mutations in alpha-synuclein and ubiquitin C-terminal hydrolase as rare causes of autosomal dominant PD and mutations in parkin as a cause of autosomal recessive PD. Functional characterization of the identified disease genes implicates the ubiquitin-mediated protein degradation pathway in these hereditary forms of PD and also in the more common sporadic forms of PD. Subsequent identification of further loci in familial PD and diverse genetic factors modulating the risk for sporadic PD point to substantial genetic heterogeneity in the disease. Thus, new candidate genes are expected to encode proteins either involved in ubiquitin-mediated protein degradation or sequestrated in intracytoplasmic protein aggregations. Future identification of disease genes is required to confirm this hypothesis, thereby unifying the clinical and genetic heterogeneity of PD, including the common sporadic form of the disease, by one biochemical pathway. [less ▲]

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See detailInfluence of Surface Treatments on DC-Performance of GaN-Based HFETs
Mistele, D.; Rotter, T.; Bougrioua, Z. et al

in Physica Status Solidi A. Applications and Materials Science (2002), 194(2), 452-455

This work reports on the influence of the surface and the gate length on the performance of AlGaN/GaN based Hetero Field Effect Transistors (HFETs). Differently NH4Sx treated surfaces result in variation ... [more ▼]

This work reports on the influence of the surface and the gate length on the performance of AlGaN/GaN based Hetero Field Effect Transistors (HFETs). Differently NH4Sx treated surfaces result in variation of the drain current IDmax of more then 100%. Gate recessing by photoelectrochemical treatment changes the threshold voltage Vth but affects the drain current little. Next, the reduction of the gate length increases the IDmax further by more than 60%. The IDmax values for the transistors are 350 mA mm––1 for the NH4Sx-treated, 850 mA for the untreated, and 1.43 A mm––1 for the one with a 0.2 mm gate length. The corresponding transconductances gm are 66, 150, and 280 mS mm––1, respectively. Surface analysis with Auger Electron Spectroscopy (AES) and contact characterization (TLM) reveals, that the NH4Sx treatment removes the native oxide and increases the contact resistance as well. Therefore we attribute the increase of IDmax and gm mainly to a beneficial behavior of gallium-oxide at the surface on the sheet carrier density nS of the 2DEG at the heterointerface. [less ▲]

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See detailZum Einfluss der Berufswahlmotive auf die Berufszufriedenheit von Grundschullehrern
Martin, Romain UL; Steffgen, Georges UL

in Psychologie in Erziehung und Unterricht (2002), 49

In dieser Studie wurde überprüft, ob sich die Berufszufriedenheit von Grundschullehrern aus den Berufswahlmotiven bei Studienantritt ableiten lässt. Dabei wurden die Probleme beim Berufseinstieg in der ... [more ▼]

In dieser Studie wurde überprüft, ob sich die Berufszufriedenheit von Grundschullehrern aus den Berufswahlmotiven bei Studienantritt ableiten lässt. Dabei wurden die Probleme beim Berufseinstieg in der Funktion eines Mediators berücksichtigt. Die Berufswahlmotive und Probleme beim Berufseintritt wurden bei 402 luxemburgischen Grundschullehrern retrospektiv anhand eines Fragebogens erfasst. Ebenfalls ermittelt wurde die aktuelle Berufszufriedenheit. Mittels eines Strukturgleichungsmodells wurden die Beziehungen zwischen den relevanten Variablen dargestellt. Bei geringer Effektstärke konnten sowohl direkte als auch indirekte Einflüsse der Berufswahlmotive auf die Berufszufriedenheit belegt werden. Lehrer, welche ihre Berufswahl stärker mit einem positiven Berufsbild und weniger mit der Suche nach Annehmlichkeiten bei der Ausbildung und beim Berufsleben begründeten, gaben auch weniger Probleme beim Berufseinstieg an und zeigten sich zufriedener in der Ausübung ihres Berufes. Bestimmte Risikokonstellationen von Berufswahlmotiven können also bereits bei Studienantritt identifiziert werden. Mögliche Schlussfolgerungen für die Berufsberatung von lehramtsstudierenden werden diskutiert. [less ▲]

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See detailZur Entwicklung der Überrepräsentanz von Migrantenjugendlichen an Sonderschulen in der BRD seit 1991
Powell, Justin J W UL; Wagner, Sandra

in Gemeinsam Leben: Zeitschrift für Integrative Erziehung (2002), 10(2), 66-71

Der Blick auf den Sonderschulbesuch von Kindern und Jugendlichen mit Migrationshintergrund bildet einen wichtigen Indikator für ihre Partizipationschancen im deutschen Bildungssystem. Daher beschäftigt ... [more ▼]

Der Blick auf den Sonderschulbesuch von Kindern und Jugendlichen mit Migrationshintergrund bildet einen wichtigen Indikator für ihre Partizipationschancen im deutschen Bildungssystem. Daher beschäftigt sich der Beitrag mit der Frage, ob sich der überproportional hohe Anteil an Kindern nichtdeutscher Herkunft auf Sonderschulen verändert hat und welche regionalen Unterschiede festzustellen sind. Dies wird mit Hilfe der Daten der amtlichen Statistik - insbesondere für die letzten zehn Jahre - untersucht. Die Berechnungen für die deutschen und nichtdeutschen Schüler/innen mit sonderpädagogischem Förderbedarf an Sonderschulen sind der Publikation Sonderpädagogische Förderung in Schulen 1990 bis 1999 (KMK 2001a) entnommen. Die Analysen des Beitrages zeigen, dass die deutliche Benachteiligung nichtdeutscher Jugendlicher im Bildungssystem auch in den 90er Jahren nicht abgebaut wurden, sondern sich eher noch verschärft hat. [less ▲]

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See detailThe philosophy of educational leadership: Emerging themes and emerging perspectives.
Mirón,L.F.; Biesta, Gert UL

in Studies in Philosophy & Education (2002), 21(2), 101-102

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See detailVerbal structure of numerals and digits handwriting: new evidence from kinematics.
Lochy, Aliette UL; Pillon, Agnesa; Zesiger, Pascal et al

in The Quarterly journal of experimental psychology. A, Human experimental psychology (2002), 55(1), 263-88

Two experiments used a digitizing tablet to analyse the temporal, spatial, and kinematic characteristics of handwritten production of arabic numbers. They addressed a specific issue of the numerical ... [more ▼]

Two experiments used a digitizing tablet to analyse the temporal, spatial, and kinematic characteristics of handwritten production of arabic numbers. They addressed a specific issue of the numerical domain: Does the lexical and syntactic structure of verbal numerals influence the production of arabic numerals (Experiments 1 and 2), even after enforced semantic processing in a comparison task (Experiment 2)? Subjects had to write multi-digit arabic numerals (e.g., 1200) presented in two different verbal structures: a multiplicative one (e.g., teen-hundred, douze cents (twelve hundred)) or an additive one (e.g., thousand-unit-hundred, mille deux cents (one thousand two hundred)). Results show differences in the inter-digit jumps that reflect the influence of the structure of verbal numerals, even after the semantic task. This finding is discussed with regard to different models of number transcoding (McCloskey, Caramazza, & Basili, 1985; Power & Dal Martello, 1990, 1997). [less ▲]

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See detailShipping news. The implications of electronic commerce for logistics and freight transportation.
Hesse, Markus UL

in Resources, Conservation & Recycling (2002), 36(3), 211-240

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See detailReview of Priestley, Mark (Ed.), Disability and the Life Course: Global Perspectives, Cambridge: Cambridge University Press, 2001
Powell, Justin J W UL

in Kölner Zeitschrift für Soziologie und Sozialpsychologie (2002), 54(3), 397-398

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See detailEindrucksbildung aus Personbeschreibungen: Der Einfluss der syntaktischen Kohärenz auf die soziale Kognition
Wintermantel, Margret; Krolak-Schwerdt, Sabine UL

in Zeitschrift für Sozialpsychologie (2002), 33

This paper concerns the comprehension of person descriptions. In two experiments we investigated the influence of syntactical coherence and ease of categorization of the information on person memory and ... [more ▼]

This paper concerns the comprehension of person descriptions. In two experiments we investigated the influence of syntactical coherence and ease of categorization of the information on person memory and judgments. Ss listened to person descriptions which contained phrases concerning single person attributes. These phrases were either highly connected by prepositions or totally unconnected. In addition, the texts differed in their degree of categorizability, one activating a social stereotype and the other containing individual attributes. In Experiment I the Ss had to reproduce the text and in Experiment II the task was to summarize the information. In Experiment I the reproduction rates increased significantly with the connectedness in the case of non-stereotypical information. In Experiment II, we found more complex inference patterns under the same condition. The results are discussed within the associative network approach to person memory. It is argued that this approach has to be further differentiated with regard to particular logical relations between person attributes. [less ▲]

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See detailComment on "Nature of the recent vertical ground movements inferred from high-precision leveling data in an intraplate setting: NE Ardenne, Belgium" by A. Demoulin and A. Collignon
Camelbeeck, Thierry; Van Camp, Michel; Jongmans, Denis et al

in Journal of Geophysical Research (2002), 107(B11), 2281-2281

Comment on ‘‘Nature of the recent vertical ground movements inferred from high-precision leveling data in an intraplate setting: NE Ardenne, Belgium’’ by A. Demoulin and A. Collignon

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See detailOptical and x-ray evidence of the de vries sm-A*-sm-C* transition in a non-layer shrinkage ferroelectric liquid crystal with very weak interlayer tilt correlation
Lagerwall, Jan UL; Giesselmann, Frank; Radcliffe, M. D.

in Physical Review. E. (2002), 66(3), 031703

A non-layer-shrinkage fluorinated ferroelectric liquid crystal compound, 8422@2F3\#, has been characterized by means of optical, x-ray, and calorimetric methods. The orientational distribution within ... [more ▼]

A non-layer-shrinkage fluorinated ferroelectric liquid crystal compound, 8422@2F3\#, has been characterized by means of optical, x-ray, and calorimetric methods. The orientational distribution within macroscopic volumes determined through wide-angle x-ray scattering and birefringence measurements, was found to be identical in the Sm-A* and helical Sm-C* phases. Together with the absence of layer shrinkage, this constitutes strong evidence that the second-order Sm-A*–Sm-C* transition in this material is well described by the diffuse cone model of de Vries. The absolute values of the layer spacing show that the molecules aggregate to antiparallel pairs. The molecular interaction across the layer boundaries will then occur only between fluorine atoms, leading to unusually weak interlayer tilt direction correlation. This explains the experimental observations of a very easily disturbed Sm-C* helix and a peculiar surface-stabilized texture. Tilt angle and birefringence values as a function of field and temperature have been evaluated in the Sm-A* and Sm-C* phases and the results corroborate the conclusions from the x-ray investigations. [less ▲]

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See detailAvancées du droit communautaire dans les procédures collectives du secteur financier
Prüm, André UL

in Revue de Droit Bancaire et Financier (2002), (5), 243

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See detailThe balance model : Hindrance or support for the solving of linear equations with one unknown
Vlassis, Joëlle UL

in Educational Studies in Mathematics (2002)

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See detailPlädoyer für die Förderung eigenverantworteter Spiritualität unter Christen
Weber, Jean-Marie UL

in Forum für Politik, Gesellschaft und Kultur in Luxemburg (2002)

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See detailThymopoiesis requires Pax9 function in thymic epithelial cells.
Hetzer-Egger, Claudia; Schorpp, Michael; Haas-Assenbaum, Annette et al

in European Journal of Immunology (2002), 32(4), 1175-81

The epithelial thymic anlage develops from the third pharyngeal pouch. Pax9 is expressed in the entire pharyngeal endoderm, and its function is required for normal development of organs derived from ... [more ▼]

The epithelial thymic anlage develops from the third pharyngeal pouch. Pax9 is expressed in the entire pharyngeal endoderm, and its function is required for normal development of organs derived from pharyngeal pouches. Here, we show that in Pax9 null mice, the thymic anlage develops as an ectopic polyp-like structure in the larynx. It expresses Whn/Foxn1, a marker of thymic epithelium, but fails to perform the normal caudo-ventral movement to the upper mediastinum. The thymic rudiment contains mesenchymal cells, blood vessels and is colonized by T cell progenitors. However, from embryonic day 14.5 onwards, the size of the Pax9 mutant thymus is severely reduced. Whereas expression of TCRbeta chain genes is readily detectable in the mutant thymus, no expression of the TCRgamma chain was detectable. Our results identify a new genetically defined control point of thymopoiesis. [less ▲]

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See detailSub art. 213-217
Allegrezza, Silvia UL

in Codice di procedura penale commentato (2002)

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See detailFunctional organization of the yeast proteome by systematic analysis of protein complexes.
Gavin, Anne-Claude; Bosche, Markus; Krause, Roland UL et al

in Nature (2002), 415(6868), 141-7

Most cellular processes are carried out by multiprotein complexes. The identification and analysis of their components provides insight into how the ensemble of expressed proteins (proteome) is organized ... [more ▼]

Most cellular processes are carried out by multiprotein complexes. The identification and analysis of their components provides insight into how the ensemble of expressed proteins (proteome) is organized into functional units. We used tandem-affinity purification (TAP) and mass spectrometry in a large-scale approach to characterize multiprotein complexes in Saccharomyces cerevisiae. We processed 1,739 genes, including 1,143 human orthologues of relevance to human biology, and purified 589 protein assemblies. Bioinformatic analysis of these assemblies defined 232 distinct multiprotein complexes and proposed new cellular roles for 344 proteins, including 231 proteins with no previous functional annotation. Comparison of yeast and human complexes showed that conservation across species extends from single proteins to their molecular environment. Our analysis provides an outline of the eukaryotic proteome as a network of protein complexes at a level of organization beyond binary interactions. This higher-order map contains fundamental biological information and offers the context for a more reasoned and informed approach to drug discovery. [less ▲]

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See detailIst das Gedächtnis für klinisch-diagnostische Personmerkmale abhängig vom Verarbeitungsziel?
Krolak-Schwerdt, Sabine UL; le Coutre, Christine

in Psychologische Beiträge (2002), 44(3), 428-446

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See detailA new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor.
Hortner, Michael; Nielsch, Ulrich; Mayr, Lorenz M. et al

in European Journal of Biochemistry (2002), 269(10), 2516-26

Erythropoietin (Epo) is a hematopoietic cytokine that is crucial for the differentiation and proliferation of erythroid progenitor cells. Epo acts on its target cells by inducing homodimerization of the ... [more ▼]

Erythropoietin (Epo) is a hematopoietic cytokine that is crucial for the differentiation and proliferation of erythroid progenitor cells. Epo acts on its target cells by inducing homodimerization of the erythropoietin receptor (EpoR), thereby triggering intracellular signaling cascades. The EpoR encompasses eight tyrosine motifs on its cytoplasmic tail that have been shown to recruit a number of regulatory proteins. Recently, the feedback inhibitor suppressor of cytokine signaling-3 (SOCS-3), also referred to as cytokine-inducible SH2-containing protein 3 (CIS-3), has been shown to act on Epo signaling by both binding to the EpoR and the EpoR-associated Janus kinase 2 (Jak2) [Sasaki, A., Yasukawa, H., Shouda, T., Kitamura, T., Dikic, I. & Yoshimura, A. (2000) J. Biol. Chem 275, 29338-29347]. In this study tyrosine 401 was identified as a binding site for SOCS-3 on the EpoR. Here we show that human SOCS-3 binds to pY401 with a Kd of 9.5 microm while another EpoR tyrosine motif, pY429pY431, can also interact with SOCS-3 but with a ninefold higher affinity than we found for the previously reported motif pY401. In addition, SOCS-3 binds the double phosphorylated motif pY429pY431 more potently than the respective singly phosphorylated tyrosines indicating a synergistic effect of these two tyrosine residues with respect to SOCS-3 binding. Surface plasmon resonance analysis, together with peptide precipitation assays and model structures of the SH2 domain of SOCS-3 complexed with EpoR peptides, provide evidence for pY429pY431 being a new high affinity binding site for SOCS-3 on the EpoR. [less ▲]

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See detailAlGaN/GaN HEMTs on Silicon Substrates with f¬T of 32/20 GHz and fmax of 27/22 GHz for 0.5/0.7 µm gate length,
Javorka, P.; Alam, A.; Fox, A. et al

in Electronics Letters (2002), 38(2002), 288-289

AlGaN/GaN HEMTs on silicon substrates have been realised and their static and small signal characteristics investigated. The AlGaN/GaN (x=0.23) material structures were grown on (111) p-Si by LP-MOVPE ... [more ▼]

AlGaN/GaN HEMTs on silicon substrates have been realised and their static and small signal characteristics investigated. The AlGaN/GaN (x=0.23) material structures were grown on (111) p-Si by LP-MOVPE. Devices exhibit a saturation current density of 0.53 to 0.68 A/mm and a peak extrinsic transconductance of 110 mS/mm. A unity gain frequency of 20 and 32 GHz and a maximum frequency of oscillation of 22 and 27 GHz are obtained for devices with a gate length of 0.7 and 0.5 mm, respectively. These values are the highest reported so far on AlGaN=GaN=Si HEMTs and are comparable to those known for devices using sapphire and SiC substrates. [less ▲]

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See detailL’influence du sexe sur les variables conatives et sur la performance illustrée par l’exemple des mathématiques.
Kerger, Sylvie UL

in Psychologie différentielle : recherches et réflexions (2002)

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See detailAlGaN/GaN HEMTs on (111) Silicon Substrates
Javorka, P.; Alam, A.; Wolter, M. et al

in IEEE Electron Device Letters (2002), 23(2002), 4-6

AlGaN/GaN HEMTs on silicon substrates have been fabricated and their static and small-signal RF characteristics investigated. The AlGaN/GaN material structures were grown on (111) p-Si by LP-MOVPE ... [more ▼]

AlGaN/GaN HEMTs on silicon substrates have been fabricated and their static and small-signal RF characteristics investigated. The AlGaN/GaN material structures were grown on (111) p-Si by LP-MOVPE. Devices exhibit a saturation current of 0.91 A/mm, a good pinchoff and a peak extrinsic transconductance of 122 mS/mm. A unity current gain frequency of 12.5 GHz and fmax/fT=0.83 were obtained. The highest saturation current reported so far, static output characteristics of up to 20 V and breakdown voltage at pinchoff higher than 40 V demonstrate that the devices are capable of handling 16 W/mm static heat dissipation. [less ▲]

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See detailThermal Glass Transition Beyond the Vogel-Fulcher-Tammann Behavior for Glass Forming Diglycidylether of Bisphenol A
Krüger, Jan-Kristian UL; Britz, Th; Baller, Jörg UL et al

in Physical Review Letters (2002), 89

For the low molecular weight fragile liquid diglycidyl ether of bisphenol A we report, based on Brillouin and dielectric spectroscopy, on a thermal glass transition where the relaxation time of the α ... [more ▼]

For the low molecular weight fragile liquid diglycidyl ether of bisphenol A we report, based on Brillouin and dielectric spectroscopy, on a thermal glass transition where the relaxation time of the α process does not go to infinity. Instead, the structural α relaxation disappears spontaneously at the transition point. That discontinuity in relaxation time coincides with a kink in the longitudinal hypersonic velocity and determines unambiguously the transition from the liquid to the glassy state. [less ▲]

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See detailExpression and functional analyses of novel mutations of ATP-binding cassette transporter-1 in Japanese patients with high-density lipoprotein deficiency
Nishida, Y.; Hirano, K.; Tsukamoto, K. et al

in Biochemical and Biophysical Research Communications (2002), 290(2), 713-721

ATP-binding cassette transporter-1 (ABCA1) gene is mutated in patients with familial high-density lipoprotein deficiency (FHD). In order to know the molecular basis for FHD, we characterized three ... [more ▼]

ATP-binding cassette transporter-1 (ABCA1) gene is mutated in patients with familial high-density lipoprotein deficiency (FHD). In order to know the molecular basis for FHD, we characterized three different ABCA1 mutations associated with FHD (G1158A/A255T, C5946T/R1851X, and A5226G/N1611D) with respect to their expression in the passaged fibroblasts from the patients and in the cells transfected with themutated cDNAs. Fibroblasts from the all patients showed markedly decreased cholesterol efflux to apolipoprotein (apo)-Al. In the fibroblasts homozygous for G1158A/A255T, the immunoreactive mass of ABCA1 could not be detected, even when stimulated by 9-cisretinoic acid and 22-R- hydroxycholesterol. In the fibroblasts homozygous for C5946T/R1851X, ABCA1 mRNA was comparable. Because the mutant ABCA1 protein (R1851X) was predicted to lack the epitope for the antibody used, we transfected FLAG-tagged truncated mutant (R1851X/ABCA1-FLAG) cDNA into Cos-7 cells, showing that the mutant protein expression was markedly reduced. The expression of N1611D ABCA1 protein was comparable in both fibroblasts and overexpressing cells, although cholesterol efflux from the cells was markedly reduced. These data indicated that, in the three patients investigated, the abnormalities and dysfunction of ABCA1 occurred at the different levels, providing important information about the expression, regulation, and function of ABCA1. [less ▲]

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See detailV76D mutation in a conserved gD-crystallin region leads to dominant cataracts in mice.
Graw, Jochen; Loster, Jana; Soewarto, Dian et al

in Mammalian Genome (2002), 13(8), 452-5

During a large-scale ENU mutagenesis screen, a mouse mutant with a dominant cataract was detected and referred to as Aey4. Aim of this study was the morphological description of the mutant, the mapping of ... [more ▼]

During a large-scale ENU mutagenesis screen, a mouse mutant with a dominant cataract was detected and referred to as Aey4. Aim of this study was the morphological description of the mutant, the mapping of the mutation, and the characterization of the underlying molecular lesion. The slit-lamp examination revealed a strong nuclear cataract surrounded by a homogeneous milky opacity in the inner cortex. The histological analysis demonstrated remnants of cell nuclei throughout the entire lens. The mutation was mapped to Chromosome 1 by a genome-wide linkage making the six gamma-crystallin encoding genes and the closely linked betaA2-crystallin encoding gene to relevant candidate genes. Finally, a T-->A exchange in exon 2 of the gammaD-crystallin encoding gene (symbol: Crygd) was demonstrated to be causative for the cataract phenotype; this particular mutation is, therefore, referred to Crygo(Aey4). The alteration in codon 76 leads to an amino acid exchange of Val-->Asp. Val at this position is highly conserved; it is found in all mouse and rat gammaD/E/F-crystallins as well as in the human gammaA- and gammaD-crystallins. It may be replaced solely by Ile, which is present in all bovine gamma-crystallins, in the rat and mouse gammaA/B/C-crystallins, as well as in the human gammaB/C-crystallins. It is predicted that the exchange of a hydrophobic side chain by a polar and acidic one might influence the microenvironment by a dramatic decrease of the isoelectric point by 1.5 pH units in the 10 amino acids surrounding position 76. The Crygd(Aey4) additionally demonstrates the importance of the integrity of the Cryg gene cluster for lens transparency. [less ▲]

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See detailTruncation mutations in ABCA1 suppress normal upregulation of full-length ABCA1 by 9-cis-retinoic acid and 22-R-hydroxycholesterol
Wellington, C. L.; Yang, Y. Z.; Zhou, S. et al

in Journal of Lipid Research (2002), 43(11), 1939-1949

Mutations in ABCA1 uniformly decrease plasma HDL-cholesterol (HDL-C) and reduce cholesterol efflux, yet different mutations in ABCA1 result in different phenotypic effects in heterozygotes. For example ... [more ▼]

Mutations in ABCA1 uniformly decrease plasma HDL-cholesterol (HDL-C) and reduce cholesterol efflux, yet different mutations in ABCA1 result in different phenotypic effects in heterozygotes. For example, truncation mutations result in significantly lower HDL-C and apoliprotein A-I (apoA-I) levels in heterozygotes compared with nontruncation mutations, suggesting that truncation mutations may negatively affect the wild-type allele. To specifically test this hypothesis, we examined ABCA1 protein expression in response to 9-cis-retinoic acid (9-cis-RA) and 22-R-hydroxycholesterol (22-R-OH-Chol) in a collection of human fibroblasts representing eight different mutations and observed that truncation mutations blunted the response to oxysterol stimulation and dominantly suppressed induction of the remaining full-length allele to 5–10% of wild-type levels. mRNA levels between truncation and nontruncation mutations were comparable, suggesting that ABCA1 expression was suppressed at the protein level. Dominant negative activity of truncated ABCA1 was recapitulated in an in vitro model using transfected Cos-7 cells. Our results suggest that the severe reduction of HDL-C in patients with truncation mutations may be at least partly explained by dominant negative suppression of expression and activity of the remaining full-length ABCA1 allele. [less ▲]

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See detailLes devoirs d'information de l'investisseur sur les marchés spéculatifs aux Etats-Unis
Conac, Pierre-Henri UL

in Revue de Droit Bancaire et Financier (2002), (6), 354-359

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See detailCombining Beamforming with Orthogonal Space-Time Block Coding
Jöngren, George; Skoglund, Mikael; Ottersten, Björn UL

in IEEE Transactions on Information Theory (2002), 48

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See detailStudies in Philosophy and Education Volume 21
Biesta, Gert UL

in Studies in Philosophy & Education (2002), 21

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See detailNegotiating the precautionary principle: Regulatory and institutional roots of divergent US and EU positions
König, Ariane UL

in International Journal of BioTechnology (2002), 4(1), 61-81

The precautionary principle has been a bone of contention in international negotiations on the governance of environmental and health risks. The US administration and European institutions often present ... [more ▼]

The precautionary principle has been a bone of contention in international negotiations on the governance of environmental and health risks. The US administration and European institutions often present opposing views on whether formal references to precaution help or hinder the global governance of risk, in particular where linked to world trade. The European Commission official position, backed by Council, Parliament and some Member States, advocates the principle's use in legal texts and pushes for the elaboration of international guidelines for its application. The proposed guidelines, whilst explicitly conforming to basic principles of trade law, include recommendations on broad socio-economic impact analyses of alternative risk mitigation measures and emphasise political aspects of decisions on risk. The US administration's official position papers oppose references to precaution and socio-economic impact analysis in international laws and guidelines on risk analysis. They mainly cite fears of abuse of the concept as guise for protectionist measures. In each administration a wide range of state and non-state actors with disparate views inform policy makers who then have to adopt one coherent position. This article suggests that overarching differences in the negotiating positions adopted by the US and European institutions, often attributed to culturally and politically rooted biases on risk and uncertainty, are also reflected in institutional practices and regulatory frameworks of the two jurisdictions. It recommends taking disparate institutional structures and regulatory frameworks into account in future deliberations on international guidelines on risk analysis. [less ▲]

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See detailHow general can Bildung be? Reflections on the future of a modern educational ideal.
Biesta, Gert UL

in Journal of Philosophy of Education (2002), 36(3), 377-390

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See detailSuppressor of cytokine signaling-3 is recruited to the activated granulocyte-colony stimulating factor receptor and modulates its signal transduction.
Hortner, Michael; Nielsch, Ulrich; Mayr, Lorenz M. et al

in Journal of immunology (2002), 169(3), 1219-27

G-CSF is a polypeptide growth factor used in treatment following chemotherapy. G-CSF regulates granulopoiesis and acts on its target cells by inducing homodimerization of the G-CSFR, thereby activating ... [more ▼]

G-CSF is a polypeptide growth factor used in treatment following chemotherapy. G-CSF regulates granulopoiesis and acts on its target cells by inducing homodimerization of the G-CSFR, thereby activating intracellular signaling cascades. The G-CSFR encompasses four tyrosine motifs on its cytoplasmic tail that have been shown to recruit a number of regulatory proteins. Suppressor of cytokine signaling 3 (SOCS-3), also referred to as cytokine-inducible Src homolgy 2-containing protein 3, is a member of a recently discovered family of feedback inhibitors that have been shown to inhibit the Janus kinase/STAT pathway. In this study, we demonstrate that human SOCS-3 is rapidly induced by G-CSF in polymorphonuclear neutrophils as well as in the myeloid precursor cell line U937 and that SOCS-3 negatively regulates G-CSFR-mediated STAT activation. Most importantly, we show that SOCS-3 is recruited to the G-CSFR in a phosphorylation-dependent manner and we identify phosphotyrosine (pY)729 as the major recruitment site for SOCS-3. Furthermore, we demonstrate that SOCS-3 directly binds to this pY motif. Surface plasmon resonance analysis reveals a dissociation constant (K(D)) for this interaction of around 2.8 microM. These findings strongly suggest that the recruitment of SOCS-3 to pY729 is important for the modulation of G-CSFR-mediated signal transduction by SOCS-3. [less ▲]

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See detailReview of R. Dirven et al. (eds) Language and Ideology
Weber, Jean-Jacques UL

in BELL. Belgian Journal of English Language and Literatures (2002), 11

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See detailMagnetic microstructure and properties of the nanocrystalline hard magnet terbium
Weissmüller, J.; Michels, D.; Michels, Andreas UL et al

in Physica Status Solidi A. Applied Research (2002), 189

We present an experimental study of the magnetic properties and magnetic microstructure in the nanocrystalline hard magnet Tb. Field-dependent small-angle neutron scattering (SANS) data suggest that up to ... [more ▼]

We present an experimental study of the magnetic properties and magnetic microstructure in the nanocrystalline hard magnet Tb. Field-dependent small-angle neutron scattering (SANS) data suggest that up to applied fields of several Tesla the magnetization remains locked in to the basal planes of the hcp crystal lattice of each individual crystallite; as a consequence, domain-wall movement along the basal planes is eliminated as a mechanism for magnetization reversal, and the coercive field is substantially increased. [less ▲]

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See detailCross-border production systems and cross-border corporate cultures? The case of the Saar-Lorraine automotive industry.
Dörrenbächer, Peter UL; Schulz, Christian UL

in Erde: Zeitschrift der Gesellschaft für Erdkunde zu Berlin (2002), 133(1), 3-17

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See detailNeurofilament L gene is not a genetic factor of sporadic and familial Parkinson's disease.
Rahner, Nils; Holzmann, Carsten; Krüger, Rejko UL et al

in Brain research (2002), 951(1), 82-6

Mutations in two genes, alpha-synuclein and parkin, have been identified as some rare causes for familial Parkinson's disease (PD). alpha-Synuclein and parkin protein have subsequently been identified in ... [more ▼]

Mutations in two genes, alpha-synuclein and parkin, have been identified as some rare causes for familial Parkinson's disease (PD). alpha-Synuclein and parkin protein have subsequently been identified in Lewy bodies (LB). To gain further insight into the pathogenesis of PD we investigated the role of neurofilament light (NF-L), another component of LB aggregation. A detailed mutation search of the NF-L gene in 328 sporadic and familial PD patients of German ancestry revealed three silent DNA changes (G163A, C224T, C487T) in three unrelated patients. Analysis of the promoter region of the NF-L gene identified a total of three base pair substitutions defining five haplotypes. Association studies based on these haplotypes revealed no significant differences between PD patients and 344 control individuals. Therefore, NF-L is unlikely to play a major role in the pathogenesis of PD. [less ▲]

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See detail«Frontal Face and Side-Face Portraits»
Roelens, Nathalie UL

in Interdisciplinary Journal for Germanic Linguistics and Semiotic Analysis (2002)

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See detailCompte rendu: Thierry Revol: Représentation du sacré dans les textes dramatiques des XIe-XIIIe siècles en France. Paris: Champion, 1999
Cicotti, Claudio UL

in Zeitschrift für Romanische Philologie (2002), 118,(Heft 4), 744-745

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See detailSmectic filaments in colloidal suspensions of rods
Frenkel, Daan; Schilling, Tanja UL

in Physical Review. E ,Statistical, Nonlinear, and Soft Matter Physics (2002), 66(4),

In supersaturated isotropic mixtures of hard rods, smectic filaments have recently been observed. We propose a model for formation and growth of these filaments similar to the Hoffman-Lauritzen model for ... [more ▼]

In supersaturated isotropic mixtures of hard rods, smectic filaments have recently been observed. We propose a model for formation and growth of these filaments similar to the Hoffman-Lauritzen model for polymer crystallization. Filament thickness is determined by a compromise between maximizing the amount of smectic phase formed and minimizing the nucleation barrier for adding new segments to the growing filament. We compare our analytical results to kinetic Monte Carlo simulations. [less ▲]

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See detailMeasurement of a magnetic-field dependent correlation length in nanocrystalline Ni using small-angle neutron scattering
Michels, Andreas UL; Weissmüller, J.; Erb, U. et al

in Physica Status Solidi A. Applied Research (2002), 189

We have analyzed magnetic-field dependent small-angle neutron scattering data on nanocrystalline electrodeposited Ni by means of the correlation function of the spin misalignment. The approach yields a ... [more ▼]

We have analyzed magnetic-field dependent small-angle neutron scattering data on nanocrystalline electrodeposited Ni by means of the correlation function of the spin misalignment. The approach yields a correlation length lC of the spin misalignment that is a measure for the characteristic dimension of regions in which the magnetic moments are misaligned coherently into a common direction. We find that lC varies strongly with the applied magnetic field Hi with values extending from about 50 nm (larger than the value for uniformly magnetized grains) at small Hi to about 10 nm (considerably smaller than the grain size) at large applied fields. [less ▲]

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See detailPrävention der Posttraumatischen Belastungsstörung bei Bankangestellten nach einem Überfall
Steffgen, Georges UL; De Boer, Claudia; Bollendorff, Claude

in Arbeitsmedizin, Sozialmedizin, Umweltmedizin (2002), 37

Aim of the study: Years after being victims of a bank robbery, bank clerks still suffer from severe symptoms of post-traumatic stress. As a result of this problem, a preventive intervention program me to ... [more ▼]

Aim of the study: Years after being victims of a bank robbery, bank clerks still suffer from severe symptoms of post-traumatic stress. As a result of this problem, a preventive intervention program me to reduce post-traumatic stress was established and evaluated for the Luxembourgish financial sector. Methods and collective: The study describes the measures carried out after a hold-up. Using non-parametric data evaluation, the effects of the intervention program me were examined for the treatment group (n= 43) and compared with a control group (n= 29). Results: The symptoms of post-traumatic stress were significantly reduced in the group which received crisis intervention and stress debriefing. Conclusions: These results are the first evidence of the effectiveness of the multi-component programme. [less ▲]

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See detailPoésie d’amour française et musique pluriculturelle. La mise en musique du poème de Louis Aragon Gazel au fond de la nuit par le groupe Gnawa Diffusion
Hu, Adelheid UL; Dannhorn, Susanne; Luquin-Elhilali, Pauline

in Französisch Heute (2002), 33(1), 55-63

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See detailPromoter characterization and genomic organization of the gene encoding integrin-linked kinase 1
Melchior, C. A; Kreis, Stephanie UL; Janji, B. B et al

in Biochimica et Biophysica Acta-Gene Structure and Expression (2002), 1575(1-3), 117-122

Integrin-linked kinase (ILK)-1 is a 59-kDa serine-threonine protein kinase, which associates with the cytoplasmic domain of β1, β2 and β3 integrins and acts as a receptor proximal kinase regulating ... [more ▼]

Integrin-linked kinase (ILK)-1 is a 59-kDa serine-threonine protein kinase, which associates with the cytoplasmic domain of β1, β2 and β3 integrins and acts as a receptor proximal kinase regulating integrin-mediated signal transduction. We have recently identified an isoform of ILK (ILK-2), which is expressed, in a TGF-β1-dependent manner, in a highly invasive tumor cell line but not in normal adult tissues. In contrast, ILK-1 is ubiquitously expressed in normal tissues and is up-regulated in various tumors independent of TGF-β1. Here, we report the structural organization and the promoter activity of the human ILK-1 gene, contained within a 8.8-kb genomic fragment cloned from a human BAC library. The mature protein is encoded by 13 exons. The last coding exon contains the entire 3′ UTR of the ILK-1 gene, which overlaps with the complementary 3′ UTR sequence of the TAF2H gene, a TATA box binding protein-associated factor. A major transcriptional initiation start site was found 138 bp upstream of exon 1 in close proximity to a consensus initiator element (Inr). The ILK gene is transcribed by a TATA-less and CAAT-less promoter with typical features of housekeeping genes. The promoter activity was characterized by a luciferase reporter assay and the minimal sequence conferring promoter activity was 349 bp in size and located immediately upstream of exon 1. © 2002 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailKann man sagen, was man meint? Untersuchungen zu Hegels „Sinnlicher Gewißheit“
Heidemann, Dietmar UL

in Archiv für Geschichte der Philosophie (2002), 84

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See detailThe new discourses on educational leadership: An introduction.
Biesta, Gert UL; Mirón, L. F.

in Studies in Philosophy & Education (2002), 21(2), 101-107

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See detailFamiliale Vererbung von Dominanzideologien in verschiedenen sozio-ökonomischen Kontexten
Hadjar, Andreas UL; Baier, Dirk

in Zeitschrift für Politische Psychologie (2002), 10

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See detailExcluding Children from Refugee Status: Child Soldiers and Article 1F of the Refugee Convention’
Happold, Matthew UL

in American University International Law Review (2002), 17

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See detailInvestigation of AlGaN/GaN HEMTs on Si substrate using backgating
Marso, Michel UL; Wolter, M.; Javorka, P. et al

in Physica Status Solidi C. Current Topics in Solid State Physics (2002), (1), 65-68

The influence of a substrate voltage on the dc characteristics of an AlGaN/GaN HEMT on silicon (111) substrate is investigated. This effect, known as backgating, is used to study traps that are located ... [more ▼]

The influence of a substrate voltage on the dc characteristics of an AlGaN/GaN HEMT on silicon (111) substrate is investigated. This effect, known as backgating, is used to study traps that are located between substrate and 2DEG channel. The transient of the drain current after applying a negative substrate voltage is evaluated for measurements with and without illumination. Several trap contributions are resolved by measurements at different photon energies. A photocurrent is observed up to 600 nm wavelength. Up to this wavelength the backgating effect can be compensated and the drain current restored by a short light pulse. The experiments are performed on completed HEMTs, allowing investigation of the influence of device fabrication technology. [less ▲]

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