References of "Scientific journals"
     in
Bookmark and Share    
Peer Reviewed
See detailLa C.O.B. et le C.M.F. protègent les analystes financiers de l'influence du droit américain
Conac, Pierre-Henri UL

in Petites Affiches, la Loi (2003), 3(154), 3-3

Detailed reference viewed: 97 (0 UL)
Peer Reviewed
See detailAkt modulates STAT3-mediated gene expression through a FKHR (FOXO1a)-dependent mechanism
Kortylewski, M.; Feld, F.; Krüger, K. D. et al

in Journal of Biological Chemistry (2003), 278(7), 5242-9

The phosphatidylinositol 3-kinase/Akt pathway plays an important role in the signaling of insulin and other growth factors, which reportedly attenuate the interleukin-6 (IL-6)-mediated stimulation of ... [more ▼]

The phosphatidylinositol 3-kinase/Akt pathway plays an important role in the signaling of insulin and other growth factors, which reportedly attenuate the interleukin-6 (IL-6)-mediated stimulation of acute phase plasma protein genes. We investigated the effect of the protein kinase Akt on IL-6-mediated transcriptional activation. The transient expression of constitutively active Akt inhibited the IL-6-dependent activity of the alpha(2)-macroglobulin promoter in HepG2 cells, whereas expression of an inactive mutant of phosphatidylinositol-dependent kinase 1 had the opposite effect. Since Akt is known to regulate gene expression through inactivation of the transcription factor FKHR (forkhead in rhabdomyosarcoma), we examined the effect of FKHR on STAT3-mediated transcriptional regulation. Indeed, the overexpression of FKHR specifically enhanced the activity of STAT3-dependent promoters but not that of a STAT5-responsive promoter. The effect of FKHR required the presence of functional STAT3 and was abrogated by the expression of dominant negative STAT3 mutants. Furthermore, FKHR and STAT3 were shown to coimmunoprecipitate and to colocalize in the nuclear regions of IL-6-treated HepG2 cells. Our results indicate that FKHR can modulate the IL-6-induced transcriptional activity by acting as a coactivator of STAT3. [less ▲]

Detailed reference viewed: 131 (2 UL)
Full Text
Peer Reviewed
See detailThe price-volatility feedback rate: an implementable mathematical indicator of market stability
Barucci, Emilio; Malliavin, Paul; Mancino, Maria Elvira et al

in Math. Finance (2003), 13(1), 17-35

Detailed reference viewed: 205 (3 UL)
Full Text
Peer Reviewed
See detailBook review of : D. HEIL, Die Reichspolitik Bayerns unter der Regierung Herzog Albrechts V. (1550-1579), 1998
Weis, Monique UL

in Revue Belge de Philologie et d'Histoire (2003), 81

Detailed reference viewed: 5 (0 UL)
Full Text
Peer Reviewed
See detailApproximation at first and second order of m-order integrals of the fractional Brownian motion and of certain semimartingales
Gradinaru, Mihai; Nourdin, Ivan UL

in Electronic Journal of Probability (2003), 8(18), 1-26

Detailed reference viewed: 153 (3 UL)
Peer Reviewed
See detailSecurity Council Resolution 1373 and the Constitution of the United Nations
Happold, Matthew UL

in Leiden Journal of International Law (2003), 16

Detailed reference viewed: 526 (1 UL)
Peer Reviewed
See detailQuels sont les objectifs éducatifs privilégiés par les familles
Poncelet, Débora UL

in Scientia Paedagogica Experimentalis (2003), 40(1), 29-46

Detailed reference viewed: 49 (7 UL)
Full Text
See detailRESEAU DE GRAVIMETRIE ABSOLUE ALGERIEN
Francis, Olivier UL

in Bulletin des Sciences Géographiques (2003), 09(Avril), 3-9

Detailed reference viewed: 77 (7 UL)
Peer Reviewed
See detailÉtude critique de la notion de patrimoine en droit privé actuel
Hiez, David UL

in Bibliothèque de droit privé (2003), 399

Detailed reference viewed: 224 (0 UL)
Peer Reviewed
See detailAblenkung. Kafkas Idee des literarischen Suizids
Mein, Georg UL

in Zeitschrift für Deutsche Philologie (2003), (2), 266-286

Detailed reference viewed: 83 (1 UL)
Peer Reviewed
See detailForschungsprojekt Frühfranzösisch an der Universität des Saarlandes: Code-switching im Sprachunterricht anhand von Beispielen aus dem Projektcorpus "Effizienz des Frühunterrichts Französisch in saarländischen Schulen". Wie funktioniert Code-switching bei Schülern und Lehrern in der Interaktion im Unterricht?
Ehrhart, Sabine UL

in Zeitschrift für Angewandte Linguistik (2003), 39

Even though the important role of early institutional language teaching has been proved by numerous studies, the practical applications of these findings are still very rare. In the Saarland, one of the ... [more ▼]

Even though the important role of early institutional language teaching has been proved by numerous studies, the practical applications of these findings are still very rare. In the Saarland, one of the German Laender which is situated on the border with France, a pilote project examinates the learning behaviour and mechanism with German primary school children learning French, their neighbouring language, from age 6 on. The author is the coordinator of the scientific team which follows the project from a universitarian point of view. The aim of the paper is to show the important role code-switching plays in this kind of teaching environment and it tries to evaluate its importance by giving examples from different stages of progress during the first two years of learning. [less ▲]

Detailed reference viewed: 110 (0 UL)
Peer Reviewed
See detailGrundfälle zum Europarecht - 3. Teil (Organe, Handeln und Rechtswirkungen)
Cole, Mark UL; Haus, Florian C.

in Juristische Schulung : Zeitschrift für Studium und Referendariat (2003)

Detailed reference viewed: 75 (0 UL)
See detailDie Beziehung zum Schüler Eine ethische Herausforderung für Lehrende
Weber, Jean-Marie UL

in Forum für Politik, Gesellschaft und Kultur in Luxemburg (2003)

Detailed reference viewed: 54 (3 UL)
Peer Reviewed
See detail«Du toucher en peinture: trois sacrifices canoniques»
Roelens, Nathalie UL

in Voir (2003), 26/27

Detailed reference viewed: 39 (1 UL)
Peer Reviewed
See detailLearning from Levinas: A response.
Biesta, Gert UL

in Studies in Philosophy & Education (2003), 22(1), 61-68

Detailed reference viewed: 43 (0 UL)
Full Text
Peer Reviewed
See detailTesting Condtional Moment Restrictions
Tripathi, Gautam UL; Kitamura, Yuichi

in Annals of Statistics (2003), 31

Detailed reference viewed: 51 (3 UL)
Full Text
Peer Reviewed
See detailEfficient Greedy Learning of Gaussian Mixture Models
Verbeek, J. J.; Vlassis, Nikos UL; Kröse, B.

in Neural Computation (2003), 15(2), 469-485

This article concerns the greedy learning of gaussian mixtures. In the greedy approach, mixture components are inserted into the mixture one aftertheother.We propose a heuristic for searching for the ... [more ▼]

This article concerns the greedy learning of gaussian mixtures. In the greedy approach, mixture components are inserted into the mixture one aftertheother.We propose a heuristic for searching for the optimal component to insert. In a randomized manner, a set of candidate new components is generated. For each of these candidates, we find the locally optimal new component and insert it into the existing mixture. The resulting algorithm resolves the sensitivity to initialization of state-of-the-art methods, like expectation maximization, and has running time linear in the number of data points and quadratic in the (final) number of mixture components. Due to its greedy nature, the algorithm can be particularly useful when the optimal number of mixture components is unknown. Experimental results comparing the proposed algorithm to other methods on density estimation and texture segmentation are provided. [less ▲]

Detailed reference viewed: 77 (0 UL)
Peer Reviewed
See detailImpaired insulin secretory capacity in mice lacking a functional vitamin D receptor.
Zeitz, Ute; Weber, Karin; Soegiarto, Desi W. et al

in FASEB Journal (2003), 17(3), 509-11

It was the aim of this study to further explore the functional role of vitamin D in the endocrine pancreas. By gene targeting, we have recently generated mice in which a lacZ reporter gene is driven by ... [more ▼]

It was the aim of this study to further explore the functional role of vitamin D in the endocrine pancreas. By gene targeting, we have recently generated mice in which a lacZ reporter gene is driven by the endogenous vitamin D receptor (VDR) promoter. These mice express a functionally inactive mutant VDR. Pancreatic islets but not exocrine pancreas cells showed strong lacZ reporter gene expression in mutant mice. To rule out possible influences of hypocalcemia on pancreatic endocrine function, a rescue diet enriched with calcium, phosphorus, and lactose was fed to wild-type (WT) and VDR mutant mice. The rescue diet normalized body weight and mineral homeostasis in VDR mutants. In glucose tolerance tests, baseline blood glucose levels were unchanged in fasting VDR mutants. However, blood glucose was elevated after oral or subcutaneous glucose loading, and maximum serum insulin levels were reduced by approximately 60% in VDR mutants vs. WT mice on either diet. In addition, insulin mRNA levels were decreased in VDR mutant mice on both diets, whereas pancreatic beta cell mass, islet architecture, and islet neogenesis were normal. These findings clearly establish a molecular role of the vitamin D-responsive elements in pancreatic insulin synthesis and secretion in vivo. [less ▲]

Detailed reference viewed: 129 (0 UL)
See detailForum Comment
König, Ariane UL

in Science & Technology (2003), XX

Detailed reference viewed: 120 (9 UL)
Peer Reviewed
See detail‘C'est canard’ – ‘C'est un vert’. Der Artikelgebrauch im frühen gesteuerten Erwerb des Französischen
Ziegler, Gudrun UL; Mutz, Katrin

in Zeitschrift für Literaturwissenschaft und Linguistik [= LiLi] (2003), 33(131), 76-105

At an early stage of instructed foreign language learning (French), young learners develop a simplest language which reflects similarities with adult learner varieties, Creole systems and strategies of ... [more ▼]

At an early stage of instructed foreign language learning (French), young learners develop a simplest language which reflects similarities with adult learner varieties, Creole systems and strategies of (first) language acquisition. Due to the fact that their L1 (German) has still to be extended, especially in terms of the written variety, learners interact in an environment with specific language use. Considering young learners language production, examples of article use in instructed interaction were investigated. [less ▲]

Detailed reference viewed: 133 (0 UL)
Full Text
Peer Reviewed
See detailConductivity and Hall effect measurements on intentionally undoped and doped AlGaN/GaN heterostructures before and after passivation,
Bernat, J.; Javorka, P.; Marso, Michel UL et al

in Applied Physics Letters (2003), 83((2003)), 5455

Conductivity and Hall effect measurements were performed before and after Si3N4 passivation of intentionally undoped and doped AlGaN/GaN heterostructures on Si and SiC substrates. An increase of the sheet ... [more ▼]

Conductivity and Hall effect measurements were performed before and after Si3N4 passivation of intentionally undoped and doped AlGaN/GaN heterostructures on Si and SiC substrates. An increase of the sheet carrier density ~up to ;30%! and a slight decrease of the electron mobility ~less than 10%! are found in all samples after passivation. The passivation induced sheet carrier density is 1.5– 231012 cm22 in undoped samples and only 0.731012 cm22 in 5–1031018 cm23 doped samples. The decrease of the electron mobility after passivation is slightly lower in highly doped samples. The channel conductivity in both types of unpassivated samples on Si and SiC substrates increases with an increase in doping density. After passivation, a well-resolved increase of channel conductivity is observed in the undoped or lightly doped samples and nearly the same channel conductivity results in the highly doped samples. [less ▲]

Detailed reference viewed: 107 (0 UL)
Full Text
Peer Reviewed
See detailThe molecular basis of myocardial hypertrophy and heart failure.
Ritter, Oliver; Neyses, Ludwig UL

in Trends in molecular medicine (2003), 9(7), 313-21

Heart failure (HF) is the inability of the heart to cope with the metabolic demands of the periphery. It is the common end-stage of many frequent cardiac diseases and is characterized by relentless ... [more ▼]

Heart failure (HF) is the inability of the heart to cope with the metabolic demands of the periphery. It is the common end-stage of many frequent cardiac diseases and is characterized by relentless progression. Mechanisms of progression include renal sodium and water retention, neurohumoral activation and alterations of the protein composition (gene programme) of the heart itself. In this review, we explain the often confusing terminology in the subject, briefly touch upon the peripheral mechanisms of HF, and then focus on the changes in the gene programme of the failing heart and the molecular mechanisms leading to them. Understanding the basic processes underlying HF will help uninitiated readers to gain insight into recent novel approaches to its treatment. [less ▲]

Detailed reference viewed: 127 (0 UL)
Full Text
Peer Reviewed
See detailDe la distinction entre comptes courant et comptes de dépôts
Prüm, André UL

in Revue de Droit Bancaire et Financier (2003), (4),

Detailed reference viewed: 210 (0 UL)
Peer Reviewed
See detailLa nuova misura cautelare dell’allontanamento dalla casa familiare
Allegrezza, Silvia UL

in in Familia (2003)

Detailed reference viewed: 185 (0 UL)
Peer Reviewed
See detailGrundfälle zum Europarecht - 4. Teil (Europäisches Prozessrecht)
Cole, Mark UL; Haus, Florian C.

in Juristische Schulung : Zeitschrift für Studium und Referendariat (2003)

Detailed reference viewed: 66 (0 UL)
Full Text
Peer Reviewed
See detailBeeinflusst die Aktivierung von Eigenschaftskategorien das interpersonelle Verhalten?
Krolak-Schwerdt, Sabine UL

in Zeitschrift für Sozialpsychologie (2003), 34

Current models of the social cognition-behavior link assume that activating a trait category induces an expectancy about a target person and a specific behavior towards this person. 60 subjects ... [more ▼]

Current models of the social cognition-behavior link assume that activating a trait category induces an expectancy about a target person and a specific behavior towards this person. 60 subjects participated in an experiment where 15 subjects were randomly assigned to the role of a target person. Each target interacted consecutively with three subjects whose category-dependent expectancy towards the target was varied. To activate different categories, subjects received attributes of a typical «extravert», a typical «introvert» or no information in the control condition. The analysis of the interaction data confirmed the hypothesis. Subjects’ behavior was significantly influenced by the prior activated category where two factors affected the quality of the behavior: (a) the content of the category and (b) the consistency between subjects’ expectancy and targets’ behavior. Theoretical implications of the results are discussed. [less ▲]

Detailed reference viewed: 124 (3 UL)
Peer Reviewed
See detailEuropean Union diabetes indicators: Fact or fiction?
De Beaufort, Carine UL; Reunanen, A.; Raleigh, V. et al

in European Journal of Public Health (2003), 13(3 SUPPL.), 51-54

Diabetes mellitus is one of the major causes of morbidity and mortality in EU/EFTA countries. Monitoring risk factors for diabetes and its complications will offer the possibility to evaluate the ... [more ▼]

Diabetes mellitus is one of the major causes of morbidity and mortality in EU/EFTA countries. Monitoring risk factors for diabetes and its complications will offer the possibility to evaluate the development in time as well as the influence of possible interventions. In this investigation a list with core and secondary indicators is proposed. Availability of these indicators and their data sources is discussed. An important variability of data sources is used in EU/EFTA countries, interfering with the comparability of the outcome. Further harmonisation as well as continuous evaluation of data sources will be necessary to provide reliable tools to monitor diabetes mellitus and its outcome on a routine basis. [less ▲]

Detailed reference viewed: 112 (0 UL)
Peer Reviewed
See detailHigher genus affine Lie algebras of Krichever-Novikov type
Schlichenmaier, Martin UL

in Moscow Mathematical Journal (2003), 3

Detailed reference viewed: 101 (0 UL)
Full Text
Peer Reviewed
See detailUnderstanding the differences between how novice and experienced designers approach design tasks
Ahmed, S.; Wallace, K. M.; Blessing, Lucienne UL

in Research in Engineering Design (2003), 14(1), 1-11

Research was undertaken to understand how to provide the most appropriate support for novice designers in engineering design. However, how designers apply their experience and knowledge is not understood ... [more ▼]

Research was undertaken to understand how to provide the most appropriate support for novice designers in engineering design. However, how designers apply their experience and knowledge is not understood and further research in this area is required. This paper describes an observational study to understand how novice and experienced designers approach design tasks. [less ▲]

Detailed reference viewed: 158 (0 UL)
Full Text
Peer Reviewed
See detailEffets des préretraites sur l'emploi
Sneessens, Henri UL; Pierrard, Olivier; Shadman, Fatemeh

in Revue Française d'Economie (2003), 18(1), 133-155

The paper analyzes the mechanisms by which policies aiming at downsizing the labour force (like early retirement policies) may in fact lead to lower employment levels, even though the equilibrium ... [more ▼]

The paper analyzes the mechanisms by which policies aiming at downsizing the labour force (like early retirement policies) may in fact lead to lower employment levels, even though the equilibrium unemployment rate is decreased. Numerical examples suggest that job losses may be potentially important, even in the case where early retirements are concentrated among groups with high unemployment levels (low-skilled workers). The model takes into account the effects coming from imperfect competition and wage negotiations, as well as those coming from frictions and matching difficulties in an economy with continuous job creations and destructions. Reducing the labour force by promoting early retirement induces in the long run an increase in labour costs, either directly through the effect of unemployment on wages, or indirectly via the effect of unemployment on hiring difficulties. [less ▲]

Detailed reference viewed: 89 (1 UL)
Full Text
Peer Reviewed
See detailLearning complex arithmetic--an fMRI study.
Delazer, M.; Domahs, F.; Bartha, L. et al

in Cognitive Brain Research (2003), 18(1), 76-88

Aim of the present functional magnet resonance imaging (fMRI) study was to detect modifications of cerebral activation patterns related to learning arithmetic. Thirteen right-handed subjects were ... [more ▼]

Aim of the present functional magnet resonance imaging (fMRI) study was to detect modifications of cerebral activation patterns related to learning arithmetic. Thirteen right-handed subjects were extensively trained on a set of 18 complex multiplication problems. In the following fMRI session, trained and untrained problems (closely matched for difficulty) were presented in blocked order alternating with a number matching task and a fact retrieval task. Importantly, left hemispheric activations were dominant in the two contrasts between untrained and trained condition, suggesting that learning processes in arithmetic are predominantly supported by the left hemisphere. Contrasting untrained versus trained condition, the left intraparietal sulcus showed significant activations, as well as the inferior parietal lobule. A further significant activation was found in the left inferior frontal gyrus. This activation may be accounted for by higher working memory demands in the untrained as compared to the trained condition. Contrasting trained versus untrained condition a significant focus of activation was found in the left angular gyrus. Following the triple-code model [Science 284 (1999) 970], the shift of activation within the parietal lobe from the intraparietal sulcus to the left angular gyrus suggests a modification from quantity-based processing to more automatic retrieval. The present study shows that the left angular gyrus is not only involved in arithmetic tasks requiring simple fact retrieval, but may show significant activations as a result of relatively short training of complex calculation. [less ▲]

Detailed reference viewed: 57 (3 UL)
Full Text
Peer Reviewed
See detailSpin relaxation in a complex environment
Esposito, Massimiliano UL; Gaspard, P.

in Physical Review. E. (2003), 68(6),

Detailed reference viewed: 111 (1 UL)
See detailOpfer werden im Kontext fremdenfeindlicher Gewalt: Gewalttätige Übergriffe trotz beschwichtigendem Opferverhalten.
Steigleder, Sandra; Willems, Helmut UL

in Zeitschrift für Gewaltprävention (2003)

Detailed reference viewed: 77 (2 UL)
Peer Reviewed
See detailJohn Dewey: retrospectief en prospectief. Naar aanleiding van zijn vijftigste sterfjaar.
Berding, Joop; Biesta, Gert UL; Miedema, S.

in Pedagogiek (2003), 23(1), 68-72

Detailed reference viewed: 74 (0 UL)
Peer Reviewed
See detailBook Review: John Rodden: Repainting the Little Red schoolhouse: a history of eastern German education 1945-1995
Karl, Ute UL

in Educational Review (2003), 55(3), 347-347

Detailed reference viewed: 71 (0 UL)
Peer Reviewed
See detailHoeffding decompositions for exchangeable sequences and chaotic representation of functionals of Dirichlet processes
Peccati, Giovanni UL

in Comptes Rendus. Mathématique (2003), 336(10), 845--850

Detailed reference viewed: 159 (0 UL)
Full Text
Peer Reviewed
See detailLiouville master equation for multielectron dynamics: Neutralization of highly charged ions near a LiF surface
Wirtz, Ludger UL; Reinhold, C. O.; Lemell, C. et al

in Physical Review. A (2003), 67(1),

We present a simulation of the neutralization of highly charged ions in front of a lithium fluoride surface including the close-collision regime above the surface. The present approach employs a Monte ... [more ▼]

We present a simulation of the neutralization of highly charged ions in front of a lithium fluoride surface including the close-collision regime above the surface. The present approach employs a Monte Carlo solution of the Liouville master equation for the joint probability density of the ionic motion and the electronic population of the projectile and the target surface. It includes single as well as double particle-hole (de)excitation processes and incorporates electron correlation effects through the conditional dynamics of population strings. The input in terms of elementary one- and two-electron transfer rates is determined from classical trajectory Monte Carlo calculations as well as quantum-mechanical Auger calculations. For slow projectiles and normal incidence, the ionic motion depends sensitively on the interplay between image acceleration towards the surface and repulsion by an ensemble of positive hole charges in the surface ("trampoline effect"). For Ne10+ we find that image acceleration is dominant and no collective backscattering high above the surface takes place. For grazing incidence, our simulation delineates the pathways to complete neutralization. In accordance with recent experimental observations, most ions are reflected as neutral or even as singly charged negative particles, irrespective of the charge state of the incoming ions. [less ▲]

Detailed reference viewed: 139 (0 UL)
Peer Reviewed
See detailLa nouvelle autorité des marchés financiers
Conac, Pierre-Henri UL

in Droit & patrimoine (2003), (121), 63-63

Detailed reference viewed: 75 (1 UL)
See detailAmbivalente Zusammenhänge: Vom Thematisieren und Vergessen des Körpers als Kategorie pädagogischen Handelns
Karl, Ute UL

in Pädagogische Rundschau (2003), 57(1), 93-108

Detailed reference viewed: 103 (1 UL)
Peer Reviewed
See detailIdentification and functional characterization of a novel R621C mutation in the synphilin-1 gene in Parkinson's disease.
Marx, Frank P.; Holzmann, Carsten; Strauss, Karsten M. et al

in Human molecular genetics (2003), 12(11), 1223-31

Synphilin-1 is linked to the pathogenesis of Parkinson's disease (PD) based on its identification as an alpha-synuclein (PARK1) and parkin (PARK2) interacting protein. Moreover, synphilin-1 is a component ... [more ▼]

Synphilin-1 is linked to the pathogenesis of Parkinson's disease (PD) based on its identification as an alpha-synuclein (PARK1) and parkin (PARK2) interacting protein. Moreover, synphilin-1 is a component of Lewy bodies (LB) in brains of sporadic PD patients. Therefore, we performed a detailed mutation analysis of the synphilin-1 gene in 328 German familial and sporadic PD patients. In two apparently sporadic PD patients we deciphered a novel C to T transition in position 1861 of the coding sequence leading to an amino acid substitution from arginine to cysteine in position 621 (R621C). This mutation was absent in a total of 702 chromosomes of healthy German controls. To define a possible role of mutant synphilin-1 in the pathogenesis of PD we performed functional analyses in SH-SY5Y cells. We found synphilin-1 capable of producing cytoplasmic inclusions in transfected cells. Moreover we observed a significantly reduced number of inclusions in cells expressing C621 synphilin-1 compared with cells expressing wild-type (wt) synphilin-1, when subjected to proteasomal inhibition. C621 synphilin-1 transfected cells were more susceptible to staurosporine-induced cell death than cells expressing wt synphilin-1. Our findings argue in favour of a causative role of the R621C mutation in the synphilin-1 gene in PD and suggest that the formation of intracellular inclusions may be beneficial to cells and that a mutation in synphilin-1 that reduces this ability may sensitize neurons to cellular stress. [less ▲]

Detailed reference viewed: 123 (1 UL)
Full Text
Peer Reviewed
See detailThe global k-means clustering algorithm
Likas, Aristidis; Vlassis, Nikos UL; Verbeek, Jakob J.

in Pattern Recognition (2003), 36(2), 451-461

We present the global k-means algorithm which is an incremental approach to clustering that dynamically adds one cluster center at a time through a deterministic global search procedure consisting of N ... [more ▼]

We present the global k-means algorithm which is an incremental approach to clustering that dynamically adds one cluster center at a time through a deterministic global search procedure consisting of N (with N being the size of the data set) executions of the k-means algorithm from suitable initial positions. We also propose modifications of the method to reduce the computational load without significantly affecting solution quality. The proposed clustering methods are tested on well-known data sets and they compare favorably to the k-means algorithm with random restarts. [less ▲]

Detailed reference viewed: 240 (1 UL)
Peer Reviewed
See detailGrundfälle zum Europarecht - 5. Teil (Grundfreiheiten und Diskriminierungsverbot)
Cole, Mark UL; Haus, Florian C.

in Juristische Schulung : Zeitschrift für Studium und Referendariat (2003)

Detailed reference viewed: 94 (0 UL)
Peer Reviewed
See detailDavid Tyack: Seeking Common Ground. Public Schools in a Diverse Society
Tröhler, Daniel UL

in Zeitschrift für Pädagogische Historiographie (2003), 10

Detailed reference viewed: 69 (2 UL)
Full Text
Peer Reviewed
See detailAcoustic profilometry within polymers as performed by Brillouin microscopy
Sanctuary, Roland UL; Bactavatchalou, R.; Müller, Ulrich UL et al

in Journal of Physics : D Applied Physics (2003), 36(21), 2738-2742

Using high performance Brillouin spectroscopy we present a new technique, which enables us to perform acoustic microscopy with a spatial resolution of about 1 μm. This technique, called Brillouin ... [more ▼]

Using high performance Brillouin spectroscopy we present a new technique, which enables us to perform acoustic microscopy with a spatial resolution of about 1 μm. This technique, called Brillouin microscopy, is tested on several bulk- and film-like polymer samples. [less ▲]

Detailed reference viewed: 118 (0 UL)
Full Text
See detailCity vs. Bits. Von der Beschleunigung der Nachrichten und der Trägheit des Raumes.
Hesse, Markus UL

in Kommune (2003), 21(5), 99-104

Detailed reference viewed: 112 (0 UL)
Peer Reviewed
See detailAn approach for dividing models of biological reaction networks into functional units
Ederer, M.; Sauter, Thomas UL; Bullinger, E. et al

in Simulation (2003), 79

Detailed reference viewed: 100 (0 UL)
Full Text
Peer Reviewed
See detailUtilisation des modules elliptiques de Drinfeld en cryptologie
Gillard, Roland; Leprévost, Franck UL; Pantchichkine, Alexei et al

in Comptes Rendus. Mathématique (2003), 336(11), 879-882

Detailed reference viewed: 52 (0 UL)
See detail"Stärken erkennen und fördern, Engpässe bearbeiten und überwinden"
Böwen, Petra UL

in Forum für Politik, Gesellschaft und Kultur in Luxemburg (2003), 229

Detailed reference viewed: 80 (11 UL)
Full Text
Peer Reviewed
See detailPsychophysiologic effects of applied tension on the emotional fainting response to blood and injury.
Vögele, Claus UL; Coles, Justine; Wardle, Jane et al

in Behaviour research and therapy (2003), 41

OBJECTIVE: The present study was designed to investigate the psychophysiologic effects of "Applied Tension" (AT) on the emotional fainting response to blood and injury in a controlled experiment. METHOD ... [more ▼]

OBJECTIVE: The present study was designed to investigate the psychophysiologic effects of "Applied Tension" (AT) on the emotional fainting response to blood and injury in a controlled experiment. METHOD: Twenty-two persons reporting to generally feel faint or to have fainted at the sight of blood or injury and 22 participants classified as Non-Fainters were randomly allocated to a treatment or control condition. Psychophysiologic responses were continuously monitored while individuals watched a video depicting open-heart surgery and a control film. Prior to the surgery film, participants in the treatment condition were instructed in the use of AT. RESULTS: All participants classified as Fainters showed a diphasic response pattern while watching the surgery film. This response, however, was significantly attenuated in Fainters in the treatment condition. CONCLUSIONS: These results suggest that AT provides an effective treatment strategy for the prevention of fainting responses in persons with a fear of blood and injury. [less ▲]

Detailed reference viewed: 119 (0 UL)
Peer Reviewed
See detailCompte rendu des premières rencontres de l’UMR de droit comparé
Poillot, Elise UL

in Zeitschrift für Europäisches Privatrecht (2003)

Detailed reference viewed: 62 (0 UL)
Peer Reviewed
See detailGabapentin reduces the mechanosensitivity of fine afferent nerve fibres in normal and inflamed rat knee joints.
Hanesch, Ulrike UL; Pawlak, Matthias; McDougall, Jason

in Pain (2003), 104

Detailed reference viewed: 86 (0 UL)
Full Text
Peer Reviewed
See detailAutomutilation révoltée ou expression culturelle ? Le cas du body piercing à Rome
Reckinger, Rachel UL

in Quasimodo (2003), (7), 37-60

Le marquage des chairs à des fins esthétiques, identitaires ou politiques (tatouages, piercings, scarifications, implants, amputations, etc.), la chirurgie, le transsexualisme, les biotechnologiques ... [more ▼]

Le marquage des chairs à des fins esthétiques, identitaires ou politiques (tatouages, piercings, scarifications, implants, amputations, etc.), la chirurgie, le transsexualisme, les biotechnologiques, l’entraînement sportif et le dopage, constituent autant de pratiques visant à modifier un corps qu’il s’agit d’amplifier, d’embellir, de réparer ou d’altérer. Ces effractions parfois radicales, ces blessures volontaires, ces inscriptions éphémères ou définitives, visibles ou secrètes, posent la question de l’acceptable et du respect de la norme corporelle. Elles ouvrent la perspective concrète d’esquiver ou d’infléchir le destin biologique et social. Les stratégies identitaires s’incarnent alors dans l’effacement ou la revendication des différences, la quête ou le refus des canons esthétiques. [less ▲]

Detailed reference viewed: 150 (2 UL)
Peer Reviewed
See detailForschungsprojekt Frühfranzösisch an der Universität des Saarlandes. Code-switching im Sprachunterrricht anhand von Beispielen aus dem Projektcorpus “Effizienz des Frühunterrichts Französisch in saarländischen Schulen“. Wie funktioniert code-switching bei Schülern und Lehrern in der Interaktion im Unterricht?
Ehrhart, Sabine UL

in Zeitschrift für Angewandte Linguistik (2003), 39

Even though the important role of early institutional language teaching has been proved by numerous studies, the practical applications of these findings are still very rare. In the Saarland, one of the ... [more ▼]

Even though the important role of early institutional language teaching has been proved by numerous studies, the practical applications of these findings are still very rare. In the Saarland, one of the German Laender which is situated on the border with France, a pilote project examinates the learning behaviour and mechanism with German primary school children learning French, their neighbouring language, from age 6 on. The author is the coordinator of the scientific team which follows the project from a universitarian point of view. The aim of the paper is to show the important role code-switching plays in this kind of teaching environment and it tries to evaluate its importance by giving examples from different stages of progress during the first two years of learning [less ▲]

Detailed reference viewed: 97 (0 UL)
Peer Reviewed
See detailMice, microbes and models of infection.
Buer, Jan; Balling, Rudi UL

in Nature Reviews. Genetics (2003), 4(3), 195-205

We urgently need animal models to study infectious disease. Mice are susceptible to a similar range of microbial infections as humans. Marked differences between inbred strains of mice in their response ... [more ▼]

We urgently need animal models to study infectious disease. Mice are susceptible to a similar range of microbial infections as humans. Marked differences between inbred strains of mice in their response to pathogen infection can be exploited to analyse the genetic basis of infections. In addition, the genetic tools that are available in the laboratory mouse, and new techniques to monitor the expression of bacterial genes in vivo, make it the principal experimental animal model for studying mechanisms of infection and immunity. [less ▲]

Detailed reference viewed: 98 (0 UL)
Full Text
Peer Reviewed
See detailWet low-temperature gate oxidation for nanoscale vertical field-effect transistors,
Goryll, M.; Moers, J.; Trellenkamp, S. et al

in Physica E: Low-Dimensional Systems and Nanostructures (2003), 19(2003), 18-22

In this work, we present an approach towards improving a vertical eld-e ect transistor based on a narrow mesa that is capable of showing complete channel inversion. Contrary to similar concepts it does ... [more ▼]

In this work, we present an approach towards improving a vertical eld-e ect transistor based on a narrow mesa that is capable of showing complete channel inversion. Contrary to similar concepts it does not necessarily require the use of an SOI substrate due to the chosen vertical layer sequence. An important issue during process flow is the limited thermal budget in order to preserve the desired channel length. Here a low-temperature wet oxidation process is investigated to prevent dopant di ffusion in early process steps. Results on the thickness homogeneity and electrical properties of this gate oxide will be presented and discussed. [less ▲]

Detailed reference viewed: 84 (1 UL)
Peer Reviewed
See detailTyrosine phosphorylation disrupts elongin interaction and accelerates SOCS3 degradation.
Haan, Serge UL; Ferguson, Paul; Sommer, Ulrike et al

in Journal of Biological Chemistry (2003), 278(34), 31972-9

The suppressors of cytokine signaling (SOCS) are negative feedback inhibitors of cytokine and growth factor-induced signal transduction. The C-terminal SOCS box region is thought to regulate SOCS protein ... [more ▼]

The suppressors of cytokine signaling (SOCS) are negative feedback inhibitors of cytokine and growth factor-induced signal transduction. The C-terminal SOCS box region is thought to regulate SOCS protein stability most likely via an elongin C interaction. In the present study, we have found that phosphorylation of SOCS3 at two tyrosine residues in the conserved SOCS box, Tyr204 and Tyr221, can inhibit the SOCS3-elongin C interaction and activate proteasome-mediated SOCS3 degradation. Jak-mediated phosphorylation of SOCS3 decreased SOCS3 protein half-life, and phosphorylation of both Tyr204 and Tyr221 was required to fully destabilize SOCS3. In contrast, a phosphorylation-deficient mutant of SOCS3, Y204F,Y221F, remained stable in the presence of activated Jak2 and receptor tyrosine kinases. SOCS3 stability correlated with the relative amount that bound elongin C, because in vitro phosphorylation of a SOCS3-glutathione S-transferase fusion protein abolished its ability to interact with elongin C. In addition, a SOCS3/SOCS1 chimera that co-precipitates with markedly increased elongin C, was significantly more stable than wild-type SOCS3. The data suggest that interaction with elongin C stabilizes SOCS3 protein expression and that phosphorylation of SOCS box tyrosine residues disrupts the complex and enhances proteasome-mediated degradation of SOCS3. [less ▲]

Detailed reference viewed: 99 (0 UL)
Peer Reviewed
See detailJugendkonflikte oder hate crime? Täter-Opfer- Konstellationen bei fremdenfeindlicher Gewalt
Willems, Helmut UL; Steigleder, Sandra

in Journal für Konflikt- und Gewaltforschung (2003), 5(1), 5-28

Detailed reference viewed: 177 (1 UL)
Full Text
Peer Reviewed
See detailPsychological responses to body shape exposure in patients with bulimia nervosa.
Tuschen-Caffier, Brunna; Vögele, Claus UL; Bracht, Susanne et al

in Behaviour research and therapy (2003), 41

One of the unresolved issues regarding research on bulimia nervosa concerns the question as to how patients diagnosed with bulimia nervosa respond to body image exposure. In addition, it remains unclear ... [more ▼]

One of the unresolved issues regarding research on bulimia nervosa concerns the question as to how patients diagnosed with bulimia nervosa respond to body image exposure. In addition, it remains unclear whether there are differential responses associated with different exposure techniques (e.g. in vivo exposure vs. exposure by visualization). The aim of the present study was to investigate psychological responses to body image exposure. Twenty participants diagnosed with bulimia nervosa (DSM IV) and twenty non-eating disordered individuals were exposed to their body image using a video recording (video confrontation). In addition, they were asked to imagine and describe the appearance of their body (imagery task). Results indicate that self-reported negative emotions increased in response to both, video confrontation and imagery task, in the clinical as well as in the control group. Furthermore, video confrontation led to more pronounced group differences than exposure by visualization (imagery task). Participants diagnosed with bulimia nervosa took less time to describe their waist, hips and bottom compared to non-eating disturbed controls. This last result could be interpreted in terms of avoidance behavior and other mechanisms during body image exposure. [less ▲]

Detailed reference viewed: 158 (0 UL)
Peer Reviewed
See detailCharacterization of Municipal Solid Waste Combustion in a Grate Furnace
Peters, Bernhard UL

in Waste Management (2003), vol. 23/8

Detailed reference viewed: 108 (0 UL)
Full Text
Peer Reviewed
See detailAutomutilation révoltée ou expression culturelle ? Le cas du body piercing à Rome
Reckinger, Rachel UL

in Quasimodo (2003), 7

Le marquage des chairs à des fins esthétiques, identitaires ou politiques (tatouages, piercings, scarifications, implants, amputations, etc.), la chirurgie, le transsexualisme, les biotechnologiques ... [more ▼]

Le marquage des chairs à des fins esthétiques, identitaires ou politiques (tatouages, piercings, scarifications, implants, amputations, etc.), la chirurgie, le transsexualisme, les biotechnologiques, l’entraînement sportif et le dopage, constituent autant de pratiques visant à modifier un corps qu’il s’agit d’amplifier, d’embellir, de réparer ou d’altérer. Ces effractions parfois radicales, ces blessures volontaires, ces inscriptions éphémères ou définitives, visibles ou secrètes, posent la question de l’acceptable et du respect de la norme corporelle. Elles ouvrent la perspective concrète d’esquiver ou d’infléchir le destin biologique et social. Les stratégies identitaires s’incarnent alors dans l’effacement ou la revendication des différences, la quête ou le refus des canons esthétiques. [less ▲]

Detailed reference viewed: 95 (1 UL)
Peer Reviewed
See detailBanković v Belgium and the Territorial Scope of the European Convention on Human Rights
Happold, Matthew UL

in Human Rights Law Review (2003), 3

Detailed reference viewed: 241 (2 UL)
Full Text
Peer Reviewed
See detailBook review of : W. REINHARDT, Ausgewählte Abhandlungen, 1997
Weis, Monique UL

in Revue Belge de Philologie et d'Histoire (2003), 81

Detailed reference viewed: 6 (0 UL)
Full Text
Peer Reviewed
See detailWeighted Group Algebras on Groups of Polynomial Growth
Fendler, Gero; Gröchenig, Karlheinz; Leinert, Michael et al

in Mathematische Zeitschrift (2003), 245(4), 791-821

Detailed reference viewed: 98 (1 UL)
Peer Reviewed
See detailTargeted disruption of the peptide transporter Pept2 gene in mice defines its physiological role in the kidney.
Rubio-Aliaga, Isabel; Frey, Isabelle; Boll, Michael et al

in Molecular and Cellular Biology (2003), 23(9), 3247-52

The peptide transporter PEPT2 mediates the cellular uptake of di- and tripeptides and selected drugs by proton-substrate cotransport across the plasma membrane. PEPT2 was functionally identified initially ... [more ▼]

The peptide transporter PEPT2 mediates the cellular uptake of di- and tripeptides and selected drugs by proton-substrate cotransport across the plasma membrane. PEPT2 was functionally identified initially in the apical membrane of renal tubular cells but was later shown to be expressed in other tissues also. To investigate the physiological importance of PEPT2 and for a detailed analysis of the protein expression sites, we generated a Pept2 knockout mouse line in which the Pept2 gene was disrupted by insertion of a beta-galactosidase gene under the control of the PEPT2 promoter. The Pept2(-/-) mice showed no obvious phenotypic abnormalities but also no adaptive upregulation in the expression level of related genes in the kidney. The importance of PEPT2 in the reabsorption of filtered dipeptides was demonstrated in knockout animals by significantly reduced renal accumulation of a fluorophore-labeled and a radiolabeled dipeptide after in vivo administration of the tracers. This indicates that PEPT2 is the main system responsible for tubular reabsorption of peptide-bound amino acids, although this does not lead to major changes in renal excretion of protein or free amino acids. [less ▲]

Detailed reference viewed: 105 (1 UL)
Full Text
Peer Reviewed
See detailL'autolimitation implicite des normes de droit privé matériel
Kinsch, Patrick UL

in Revue Critique de Droit International Privé (2003)

L'autolimitation des normes de droit matériel doit être distinguée du jeu des mécanismes du droit international privé, spécialement du jeu des règles de conflit. Elle correspond à la définition, par ... [more ▼]

L'autolimitation des normes de droit matériel doit être distinguée du jeu des mécanismes du droit international privé, spécialement du jeu des règles de conflit. Elle correspond à la définition, par certaines règles de droit matériel, de leur propre champ d'application international et n'intervient qu'à condition que le droit applicable aux termes des règles de conflit de lois soit préalablement connu. La présente contribution examine les cas dans lesquels l'autolimitation d'une norme de droit matériel n'est pas l'effet d'une disposition législative expresse, mais de l'interprétation de la norme par les tribunaux: incidence de la « présomption contre l'extraterritorialité » des normes législatives dans les pays de common law, autolimitation des lois de police, emploi par la norme de notions fermées à toute substitution... On verra ainsi apparaître le phénomène de l'autolimitation des normes comme une illustration, parmi d'autres, de la contribution des normes de droit matériel à la réglementation des situations internationales. [less ▲]

Detailed reference viewed: 138 (8 UL)
Full Text
Peer Reviewed
See detailMolecular dynamics simulation of the unfolding of the human prion protein domain under low pH and high temperature conditions
Gu, Wei UL; Wang, T. T.; Zhu, J. et al

in Biophysical Chemistry (2003), 104(1), 79-94

Four 10-ns molecular dynamics (MD) simulations of the human prion protein domain (HuPrP 125-228) in explicit water solution have been performed. Each of the simulations mimicked a different environment of ... [more ▼]

Four 10-ns molecular dynamics (MD) simulations of the human prion protein domain (HuPrP 125-228) in explicit water solution have been performed. Each of the simulations mimicked a different environment of the protein: the neutral pH environment was simulated with all histidine residues neutral and bearing a ND proton and with other titratable side chains charged, the weakly acidic environment was simulated with all titratable side chains charged, he strongly acidic environment was simulated with all titratable side chains protonated. The protein in neutral pH environment was simulated at both ambient (298 K) and higher (350 K) temperatures. The native fold is stable in he neutral pH/ambient temperature simulation. Through out all other simulations, a quite stable core consisted of 0-20 residues around the disulfide bond retain their initial conformations. However, the secondary structures of the Protein show changes of various degrees compared to the native fold, parts of the helices unfolded and the beta-sheets extended. Our simulations indicated that the heat-induced unfolding and acid-induced unfolding of HuPrP might follow different pathways: the initial stage of the acid-induced unfolding may include not only changes in secondary structures, but also changes in the tertiary structures. Under the strongly acidic condition, obvious tertiary structure changes take place after 10-ns simulation, the secondary structure elements and the loops becoming more parallel to each other, resulting in a compact state, which was stabilized by a large number of new, non-native side chain-side chain contacts. Such tertiary structure changes were not observed in the higher temperature simulation, and intuitively, they may favor the further extension of the beta-sheets and eventually the agglomeration of multiple protein molecules. The driving forces for this tertiary structure changes are discussed. Two additional 10-ns MD simulations, one with Asp202 protonated and the other with Glu196 protonated compared to the neutral pH simulation, were carried out. The results showed that the stability of the native fold is very subtle and can be strongly disturbed by eliminating a single negative charge at one of such key sites. Correlations of our results with previous experimental and theoretical studies are discussed. (C) 2003 Elsevier Science B.V. All rights reserved. [less ▲]

Detailed reference viewed: 132 (1 UL)
Full Text
Peer Reviewed
See detailInvestigation of traps in AlGaN/GaN HEMTs on silicon substrate
Wolter, M.; Marso, Michel UL; P.Javorka, J. et al

in Physica Status Solidi C. Current Topics in Solid State Physics (2003), (7), 2360-2363

Deep levels in AlGaN/GaN heterostructures are known to be responsible for trapping processes like current collapse or dispersion. In order to investigate these processes we performed different ... [more ▼]

Deep levels in AlGaN/GaN heterostructures are known to be responsible for trapping processes like current collapse or dispersion. In order to investigate these processes we performed different measurements on HEMTs fabricated with heterostructures grown on silicon substrate. First by photoionization spectroscopy we found three different traps with activation energies of about 2.1 eV, 2.9 eV and 3.2 eV. Secondly, the temperature dependent relaxation of the drain current was investigated by the backgating current deep level transient spectroscopy (DLTS) method. Hereby we detected majority and minority carrier traps in the GaN buffer at the energies EV + 0.41 eV and EC – 0.55 eV, respectively. The latter energy can be attributed to the well known “E2” level in GaN. [less ▲]

Detailed reference viewed: 103 (1 UL)
Full Text
Peer Reviewed
See detailMaterial and Device Issues of AlGaN/GaN HEMTs on Silicon Substrates
Javorka, P.; Alam, A.; Marso, Michel UL et al

in Microelectronics Journal (2003), 34

Selected material and device issues related to the performance of AlGaN/GaN HEMTs on (111) Si substrates are reported. It is shown that these devices can sustain significantly higher dc power (16 W/mm ... [more ▼]

Selected material and device issues related to the performance of AlGaN/GaN HEMTs on (111) Si substrates are reported. It is shown that these devices can sustain significantly higher dc power (16 W/mm) than those grown on sapphire. Consequently smaller degradation in the device performance at higher temperatures (up to 400 8C) is demonstrated. Photoionisation spectroscopy reveals trap level of 1.85 eV, additional to two another levels found before in GaN-based HEMTs prepared on sapphire. Thus, AlGaN/GaN HEMTs on Si substrates demonstrate the viability of this technology for commercial application of high power rf devices. [less ▲]

Detailed reference viewed: 122 (2 UL)
Full Text
Peer Reviewed
See detailLe testing adaptatif par ordinateur dans la mesure en éducation: potentialités et limites
Martin, Romain UL

in Psychologie et Psychométrie (2003), 24(2-3), 89-116

Detailed reference viewed: 101 (3 UL)
Full Text
Peer Reviewed
See detailInfluence of doping concentration on DC and RF performance of AlGaN/GaN HEMTs on silicon substrate
Marso, Michel UL; Javorka, P.; Dikme, Y. et al

in Physica Status Solidi A. Applications and Materials Science (2003), (1), 179-182

AlGaN/GaN HEMTs with different carrier supply layers are fabricated on Si substrate, using MOVPE growth technique. The influence of the carrier supply doping concentration on the HEMT properties is ... [more ▼]

AlGaN/GaN HEMTs with different carrier supply layers are fabricated on Si substrate, using MOVPE growth technique. The influence of the carrier supply doping concentration on the HEMT properties is investigated by Hall measurements and by electrical DC and RF characterisation of transistor devices. Hall mobility is found to decrease with increasing sheet concentration, while the gate leakage current increases. The device with the highest carrier supply doping concentration of 1019 cm–3 is provided with a GaN cap layer to reduce gate leakage. The transistors based on modulation doped layer structures show much higher DC performance than the undoped device. Best RF properties are obtained for a doping level of 5 × 1018 cm–3. High frequency measurements exhibit fT and fMAX values of 35 GHz and 37 GHz, respectively, for devices with 300 nm gate length. [less ▲]

Detailed reference viewed: 120 (0 UL)
Full Text
Peer Reviewed
See detailAdaptive tests of linear hypotheses by model selection
Baraud, Yannick UL; Huet, S.; Laurent, B.

in Annals of Statistics (2003), 31(1), 225--251

Detailed reference viewed: 86 (7 UL)
Peer Reviewed
See detailDécision de la Cour de Justice des Communautés européennes, Dijon, 23 avril 2002
Cuniberti, Gilles UL

in Clunet (2003)

Effet de titre des sentences arbitrales.

Detailed reference viewed: 39 (0 UL)
Full Text
Peer Reviewed
See detailA comprehensive set of protein complexes in yeast: mining large scale protein-protein interaction screens.
Krause, Roland UL; von Mering, Christian; Bork, Peer

in Bioinformatics (2003), 19(15), 1901-8

MOTIVATION: The analysis of protein-protein interactions allows for detailed exploration of the cellular machinery. The biochemical purification of protein complexes followed by identification of ... [more ▼]

MOTIVATION: The analysis of protein-protein interactions allows for detailed exploration of the cellular machinery. The biochemical purification of protein complexes followed by identification of components by mass spectrometry is currently the method, which delivers the most reliable information--albeit that the data sets are still difficult to interpret. Consolidating individual experiments into protein complexes, especially for high-throughput screens, is complicated by many contaminants, the occurrence of proteins in otherwise dissimilar purifications due to functional re-use and technical limitations in the detection. A non-redundant collection of protein complexes from experimental data would be useful for biological interpretation, but manual assembly is tedious and often inconsistent. RESULTS: Here, we introduce a measure to define similarity within collections of purifications and generate a set of minimally redundant, comprehensive complexes using unsupervised clustering. AVAILABILITY: Programs and results are freely available from http://www.bork.embl-heidelberg.de/Docu/purclust/ [less ▲]

Detailed reference viewed: 118 (4 UL)
Full Text
Peer Reviewed
See detailDifferent glassy states, as indicated by a violation of the generalized Cauchy relation.
Krüger, Jan-Kristian UL; Britz, Th; le Coutre, A. et al

in New Journal of Physics (2003), 5(80), 1-11

Using Brillouin spectroscopy as a probe for high-frequency clamped acoustic properties, a shear modulus can be measured in addition to the longitudinal modulus already well above the thermal glass ... [more ▼]

Using Brillouin spectroscopy as a probe for high-frequency clamped acoustic properties, a shear modulus can be measured in addition to the longitudinal modulus already well above the thermal glass transition. On slow cooling of the liquid through the thermal glass transition temperature Tg, both moduli show a kink-like behaviour and the function follows a generalized Cauchy relation (gCR) defined by the linear relation , which completely hides the glass transition. In this work we show experimentally that on fast cooling this linear transformation becomes violated within the glassy state, but that thermal ageing drives the elastic coefficients towards the gCR, i.e. towards a unique glassy state. [less ▲]

Detailed reference viewed: 106 (5 UL)
See detailDie Anfänge des Antoniterhospitals in Marville
Pauly, Michel UL

in Antoniter-Forum (2003), 11

Detailed reference viewed: 50 (0 UL)
Peer Reviewed
See detailExplicit formulae for time-space Brownian chaos
Peccati, Giovanni UL

in Bernoulli (2003), 9(1), 25--48

Detailed reference viewed: 132 (0 UL)
Peer Reviewed
See detailPax1 and Pax9 activate Bapx1 to induce chondrogenic differentiation in the sclerotome.
Rodrigo, Isabel; Hill, Robert E.; Balling, Rudi UL et al

in Development (2003), 130(3), 473-82

We have previously shown that the paired-box transcription factors Pax1 and Pax9 synergistically act in the proper formation of the vertebral column. Nevertheless, downstream events of the Pax1/Pax9 ... [more ▼]

We have previously shown that the paired-box transcription factors Pax1 and Pax9 synergistically act in the proper formation of the vertebral column. Nevertheless, downstream events of the Pax1/Pax9 action and their target genes remain to be elucidated. We show, by analyzing Pax1;Pax9 double mutant mice, that expression of Bapx1 in the sclerotome requires the presence of Pax1 and Pax9, in a gene dose-dependent manner. By using a retroviral system to overexpress Pax1 in chick presomitic mesoderm explants, we show that Pax1 can substitute for Shh in inducing Bapx1 expression and in initiating chondrogenic differentiation. Furthermore, we demonstrate that Pax1 and Pax9 can transactivate regulatory sequences in the Bapx1 promoter and that they physically interact with the Bapx1 promoter region. These results strongly suggest that Bapx1 is a direct target of Pax1 and Pax9. Together, we conclude that Pax1 and Pax9 are required and sufficient for the chondrogenic differentiation of sclerotomal cells. [less ▲]

Detailed reference viewed: 121 (2 UL)
Peer Reviewed
See detailHaploinsufficiency at the alpha-synuclein gene underlies phenotypic severity in familial Parkinson's disease.
Kobayashi, Hirokazu; Krüger, Rejko UL; Markopoulou, Katerina et al

in Brain : a journal of neurology (2003), 126(Pt 1), 32-42

To date, two point mutations, G209A and G88C, have been reported in the coding region of the alpha-synuclein gene in autosomal dominant familial Parkinson's disease. When translated, these lead to the ... [more ▼]

To date, two point mutations, G209A and G88C, have been reported in the coding region of the alpha-synuclein gene in autosomal dominant familial Parkinson's disease. When translated, these lead to the missense mutations Ala53Thr and Ala30Pro, respectively. Reduced mRNA expression of the G209A allele was reported recently in a Greek-American family. Here, we show that alpha-synuclein mRNA is normally expressed in blood cells and report the results of an analysis of alpha-synuclein mRNA and protein expression in lymphoblastoid cell lines established from kindreds with the G209A and G88C mutations. mRNA expression was characterized using a TaqMan real-time quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) assay. We assessed five affected and three unaffected members of a German family with the G88C mutation and two affected members in different, unrelated Greek families with the G209A mutation. The ratio of wild-type to mutant alpha-synuclein allele expression ranged from 2.2 to 9.2 in the affected individuals with a severe clinical phenotype. The ratios of the expression levels of the wild-type to mutant alleles were only slightly decreased in mild cases and were less than 1.0 in two asymptomatic heterozygotes. Sequence analysis of the RT-PCR products showed only the presence of G in position 88 and G in position 209 in severely affected heterozygotes of the German and Greek families, respectively. High performance liquid chromatography/mass spectrometry demonstrated that, relative to wild-type alpha-synuclein, there is a reduction of Ala30Pro alpha-synuclein in lymphoblastoid cell lines originating from severely affected, but not mildly affected G88C/+ heterozygotes. Taken together, these data indicate that there is haploinsufficiency at the alpha-synuclein gene and that the ratio of expression of the wild-type to mutant alleles correlates with the severity of the clinical phenotype. Furthermore, these findings suggest that haploinsufficiency of alpha-synuclein mutations may contribute to disease progression in these forms of familial Parkinson's disease. [less ▲]

Detailed reference viewed: 68 (0 UL)
Peer Reviewed
See detailCharacterization of methylthioadenosin phosphorylase (MTAP) expression in malignant melanoma
Behrmann, Iris UL; Wallner, S.; Komyod, W. et al

in American Journal of Pathology (2003), 163(2), 683-90

Homozygous deletions of human chromosomal region 9p21 occur frequently in malignant melanoma and are associated with the loss of the tumor suppressor genes p16(INK4a) and p15(INK4b). In the same ... [more ▼]

Homozygous deletions of human chromosomal region 9p21 occur frequently in malignant melanoma and are associated with the loss of the tumor suppressor genes p16(INK4a) and p15(INK4b). In the same chromosomal region the methylthioadenosine phosphorylase (MTAP) gene is localized and therefore may also serve as a tumor suppressor gene. The aim of this study was to analyze MTAP mutations and expression patterns in malignant melanomas. To examine the MTAP gene and expression of MTAP protein we screened 9 human melanoma cell lines and primary human melanocytes by reverse transcriptase-polymerase chain reaction, sequencing, and immunoblotting. Analyzing the melanoma cell lines we found significant down-regulation of MTAP mRNA expression. In only one cell line, HTZ19d, this was due to homozygous deletion of exon 2 to 8 whereas in the other cell lines promoter hypermethylation was detected. MTAP expression was further analyzed in vivo by immunohistochemical staining of 38 tissue samples of benign melanocytic nevi, melanomas, and melanoma metastases. In summary, we demonstrate significant inverse correlation between MTAP protein expression and progression of melanocytic tumors as the amount of MTAP protein staining decreases from benign melanocytic nevi to metastatic melanomas. Our results suggest an important role of MTAP inactivation in the development of melanomas. This finding may be of great clinical significance because recently an association between MTAP activity and interferon sensitivity has been suggested. [less ▲]

Detailed reference viewed: 100 (0 UL)
See detailWie genau sind alte Landkarten der Eifel?
Solchenbach, Karl UL

in Heimatkalender Bitburg-Prüm (2003)

Detailed reference viewed: 33 (1 UL)
Peer Reviewed
See detailActivation of STAT3 by IL-6 and IL-10 in primary human macrophages is differentially modulated by suppressor of cytokine signaling 3.
Niemand, Claudia; Nimmesgern, Ariane; Haan, Serge UL et al

in Journal of immunology (2003), 170(6), 3263-72

On human macrophages IL-10 acts as a more potent anti-inflammatory cytokine than IL-6, although both cytokines signal mainly via activation of the transcription factor STAT3. In this study we compare IL ... [more ▼]

On human macrophages IL-10 acts as a more potent anti-inflammatory cytokine than IL-6, although both cytokines signal mainly via activation of the transcription factor STAT3. In this study we compare IL-10 and IL-6 signaling in primary human macrophages derived from blood monocytes. Pretreatment of macrophages with PMA or the proinflammatory mediators LPS and TNF-alpha blocks IL-6-induced STAT3 activation, whereas IL-10-induced activation of STAT3 remains largely unaffected. Although LPS induces the feedback inhibitor suppressor of cytokine signaling 3 (SOCS3) in macrophages, inhibition of IL-6 signal transduction by LPS occurs rapidly and does not depend on gene transcription. We also found that pretreatment of macrophages with IL-10 inhibits subsequent STAT3 activation by IL-6, whereas IL-10-induced STAT3 activation is not affected by preincubation with IL-6. This cross-inhibition is dependent on active transcription and might therefore be explained by different sensitivities of IL-10 and IL-6 signaling toward the feedback inhibitor SOCS3, which is induced by both cytokines. In contrast to the IL-6 signal transducer gp130, which has been previously shown to recruit SOCS3 to one of its phosphotyrosine residues (Y759), peptide precipitation experiments suggest that SOCS3 does not interact with phosphorylated tyrosine motifs of the IL-10R. Taken together, different sensitivities of IL-10 and IL-6 signaling toward mechanisms that inhibit the Janus kinase/STAT pathway define an important mechanism that contributes to the different anti-inflammatory potencies of these two cytokines. [less ▲]

Detailed reference viewed: 133 (4 UL)
Peer Reviewed
See detailGrundfälle zum Europarecht - 7. Teil (Das gemeinschaftsrechtliche Wettbewerbsrecht)
Cole, Mark UL; Haus, Florian C.

in Juristische Schulung : Zeitschrift für Studium und Referendariat (2003)

Detailed reference viewed: 69 (0 UL)
Peer Reviewed
See detailDécision de la Cour de cassation, 1ère Civ., 20 mai 2003
Cuniberti, Gilles UL

in Clunet (2003)

Portée des conventions bilatérales d’entraide judiciaire.

Detailed reference viewed: 48 (0 UL)
Peer Reviewed
See detailCréation de l'autorité des marchés financiers
Conac, Pierre-Henri UL

in Revue de Droit Bancaire et Financier (2003), (5), 299-299

Detailed reference viewed: 75 (2 UL)
Full Text
Peer Reviewed
See detailMicroarray analysis of tumor necrosis factor alpha induced gene expression in U373 human glioblastoma cells.
Schwamborn, Jens Christian UL; Lindecke, Antje; Elvers, Margitta et al

in BMC Genomics (2003), 4(1), 46

BACKGROUND: Tumor necrosis factor alpha (TNF) is able to induce a variety of biological responses in the nervous system including inflammation and neuroprotection. Human astrocytoma cells U373 have been ... [more ▼]

BACKGROUND: Tumor necrosis factor alpha (TNF) is able to induce a variety of biological responses in the nervous system including inflammation and neuroprotection. Human astrocytoma cells U373 have been widely used as a model for inflammatory cytokine actions in the nervous system. Here we used cDNA microarrays to analyze the time course of the transcriptional response from 1 h up to 12 h post TNF treatment in comparison to untreated U373 cells. TNF activated strongly the NF-kappaB transcriptional pathway and is linked to other pathways via the NF-kappaB target genes JUNB and IRF-1. Part of the TNF-induced gene expression could be inhibited by pharmacological inhibition of NF-kappaB with pyrrolidine-dithiocarbamate (PDTC). NF-kappaB comprises a family of transcription factors which are involved in the inducible expression of genes regulating neuronal survival, inflammatory response, cancer and innate immunity. RESULTS: In this study we show that numerous genes responded to TNF (> 880 from 7500 tested) with a more than two-fold induction rate. Several novel TNF-responsive genes (about 60% of the genes regulated by a factor > or = 3) were detected. A comparison of our TNF-induced gene expression profiles of U373, with profiles from 3T3 and Hela cells revealed a striking cell-type specificity. SCYA2 (MCP-1, CCL2, MCAF) was induced in U373 cells in a sustained manner and at the highest level of all analyzed genes. MCP-1 protein expression, as monitored with immunofluorescence and ELISA, correlated exactly with microarray data. Based on these data and on evidence from literature we suggest a model for the potential neurodegenerative effect of NF-kappaB in astroglia: Activation of NF-kappaB via TNF results in a strongly increased production of MCP-1. This leads to a exacerbation of neurodegeneration in stoke or Multiple Sclerosis, presumably via infiltration of macrophages. CONCLUSIONS: The vast majority of genes regulated more than 3-fold were previously not linked to tumor necrosis factor alpha as a search in published literature revealed. Striking co-regulation for several functional groups such as proteasome and ribosomal proteins were detected. [less ▲]

Detailed reference viewed: 161 (7 UL)
Peer Reviewed
See detailDécision de la Cour de cassation, 2ème Civ., 21 décembre 2002
Cuniberti, Gilles UL

in Droit et Procédures (2003)

Detailed reference viewed: 42 (0 UL)
Full Text
See detailL'enseignement des sciences par énigmes scientifiques. Les enseignants se posent des questions
Vlassis, Joëlle UL; De Landsheere, Viviane; Mélon, Christophe

in Informations Pédagogiques (2003), 53

Detailed reference viewed: 85 (0 UL)
Peer Reviewed
See detailThe actin cytoskeleton as a therapeutic target: state of the art and future directions.
Giganti, Adeline; Friederich, Evelyne UL

in Progress in cell cycle research (2003), 5

Dynamic processes such as cell migration and division depend on the actin cytoskeleton, a dense meshwork of protein polymers capable of undergoing rapid cycles of assembly and disassembly, under the ... [more ▼]

Dynamic processes such as cell migration and division depend on the actin cytoskeleton, a dense meshwork of protein polymers capable of undergoing rapid cycles of assembly and disassembly, under the control of a large number of actin-associated proteins. In cancer cells, structural and functional perturbations of the actin cytoskeleton correlate with higher proliferation rates and uncontrolled movement. Therefore, small molecules that act on the actin cytoskeleton of tumour cells and thus inhibit cell division and movement, may be of high therapeutic value. The dynamic properties of the actin cytoskeleton and the mechanism of action of actin-targeting drugs will be described. [less ▲]

Detailed reference viewed: 123 (0 UL)
See detailPantofl un pantofl-mener.
Schumacher, Jutta UL

in Yiddisher Tam-Tam (Der) (2003), 39

Detailed reference viewed: 43 (0 UL)
Peer Reviewed
See detailInstruction or educating for life? On the aims of religiously affiliated and other schools.
Miedema, S.; Biesta, Gert UL

in International Journal of Education and Religion (2003), 4(1), 81-96

Detailed reference viewed: 51 (1 UL)
Full Text
Peer Reviewed
See detailCharacterization of the simple L¹(G) -modules for exponential Lie groups
Ludwig, Jean; Mint Elhacen, Salma; Molitor-Braun, Carine UL

in Pacific Journal of Mathematics (2003), 212(1), 133-156

Detailed reference viewed: 106 (1 UL)
Full Text
Peer Reviewed
See detailSemiclassical theory for transmission through open billiards: Convergence towards quantum transport
Wirtz, Ludger UL; Stampfer, C.; Rotter, S. et al

in Physical Review. E. (2003), 67(1),

We present a semiclassical theory for transmission through open quantum billiards which converges towards quantum transport. The transmission amplitude can be expressed as a sum over all classical paths ... [more ▼]

We present a semiclassical theory for transmission through open quantum billiards which converges towards quantum transport. The transmission amplitude can be expressed as a sum over all classical paths and pseudopaths which consist of classical path segments joined by "kinks," i.e., diffractive scattering at lead mouths. For a rectangular billiard we show numerically that the sum over all such paths with a given number of kinks K converges to the quantum transmission amplitude as K-->infinity. Unitarity of the semiclassical theory is restored as K approaches infinity. Moreover, we find excellent agreement with the quantum path-length power spectrum up to very long path length. [less ▲]

Detailed reference viewed: 85 (1 UL)
Peer Reviewed
See detailInternationalisierung und nationale Kontexte der Forschung
Tröhler, Daniel UL

in Zeitschrift für Pädagogische Historiographie (2003), 9(1), 31-33

Detailed reference viewed: 62 (0 UL)
Full Text
Peer Reviewed
See detailPRODORIC: prokaryotic database of gene regulation
Münch, Richard; Hiller, Karsten UL; Barg, Heiko et al

in Nucleic Acids Research (2003)

Detailed reference viewed: 89 (0 UL)