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See detailLe pouvoir de transaction de la Securities and Exchange Commission (SEC)
Conac, Pierre-Henri UL

in Bulletin Joly Bourse (2005)

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See detailMolecular dynamics simulation of truncated bovine adrenodoxin
Shakya, S. K.; Gu, Wei UL; Helms, V.

in Biopolymers (2005), 78(1), 9-20

The 128 amino acid long soluble protein adrenodoxin (Adx) is a typical member of the ferredoxin protein family that are electron carrier proteins with an iron-sulfur cofactor. Adx carries electrons from ... [more ▼]

The 128 amino acid long soluble protein adrenodoxin (Adx) is a typical member of the ferredoxin protein family that are electron carrier proteins with an iron-sulfur cofactor. Adx carries electrons from adrenodoxin reductase (AdR) to cytochrome P450s. Its binding modes to these proteins were previously characterized by site-directed mutagenesis, by X-ray crystallography for the complex Adx:AdR, and by NMR. However, no clear evidence has been provided for the driving force that promotes Adx detachment from AdR upon reduction. Here, we characterized the conformational dynamics of unbound Adx in the oxidized and reduced forms using 2-20 ns long molecular dynamics simulations. The most noticeable difference between both forms is the enhanced flexibility of the loop (47-51) surrounding the iron-sulfur cluster in the reduced form. Together with several structural displacements at the binding interface, this increased flexibility may be the key factor promoting unbinding of reduced Adx from AdR. This points to an intrinsic property of reduced Adx that drives dissociation. (c) 2005 Wiley Periodicals, Inc. [less ▲]

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See detailCondotta antisindacale della P.A., violazione di accordo di concertazione e credibilità del sindacato
Ratti, Luca UL

in Il Lavoro nelle Pubbliche Amministrazioni (2005)

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See detailMolecular basis for dissimilar nuclear trafficking of the actin-bundling protein isoforms T- and L-plastin.
Delanote, Veerle; Van Impe, Katrien; De Corte, Veerle et al

in Traffic (Copenhagen, Denmark) (2005), 6(4), 335-45

T- and L-plastin are highly similar actin-bundling proteins implicated in the regulation of cell morphology, lamellipodium protrusion, bacterial invasion and tumor progression. We show that T-plastin ... [more ▼]

T- and L-plastin are highly similar actin-bundling proteins implicated in the regulation of cell morphology, lamellipodium protrusion, bacterial invasion and tumor progression. We show that T-plastin localizes predominantly to the cytoplasm, whereas L-plastin distributes between nucleus and cytoplasm in HeLa or Cos cells. T-plastin shows nuclear accumulation upon incubation of cells with the CRM1 antagonist leptomycin B (LMB). We identified a Rev-like nuclear export sequence (NES) in T-plastin that is able to export an otherwise nuclear protein in an LMB-dependent manner. Deletion of the NES promotes nuclear accumulation of T-plastin. Mutation of residues L17, F21 or L26 in the T-plastin NES inhibits nuclear efflux. L-plastin harbors a less conserved NES and lacks the F21 T-plastin residue. Insertion of a Phe residue in the L-plastin NES specifically enhances its export activity. These findings explain why both isoforms exhibit specific distribution patterns in eukaryotic cells. [less ▲]

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See detailDie Lokalisation des Neurokinin 1-Rezeptors im Hüftgelenk von Patienten mit schmerzhafter Osteoarthrose.
Saxler, Guido; Löer, Franz; von Knoch, Marius et al

in Zeitschrift für Orthopadie und Ihre Grenzgebiete (2005), 143

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See detailReden wie Deutsche in Frankreich. Kultur prägt Kommunikation
Wille, Christian UL

in Interkulturell und global : Forum für interkulturelle Kommunikation, Erziehung, Bildung und globales Lernen (2005), (3/4), 219-222

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See detailEnsemble and UniProt (Swiss-Prot)
Jackson, D.; Schneider, Reinhard UL

in Genomics, Proteomics and Bioinformatics (2005)

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See detailPragmatic scales and the (de)construction of cultural models
Weber, Jean-Jacques UL

in Language and Literature: Journal of the Poetics and Linguistics Association (2005), 14(1), 45-63

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See detailProcessi intrafamiliari e coinvolgimento parentale, Un modello di compresione des percorso scolastico
Poncelet, Débora UL

in Psicologia Dell’ Educazione E Della Formazione (2005), 7(3), 297-314

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See detailOn the Complexity of Sphere Decoding in Digital Communications
Jaldén, Joakim; Ottersten, Björn UL

in IEEE Transactions on Signal Processing (2005), 53

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See detailThe estrogen receptor-alpha agonist 16alpha-LE2 inhibits cardiac hypertrophy and improves hemodynamic function in estrogen-deficient spontaneously hypertensive rats.
Pelzer, Theo; Jazbutyte, Virginija; Hu, Kai et al

in Cardiovascular research (2005), 67(4), 604-12

OBJECTIVE: Cardiac mass increases with age and with declining estradiol serum levels in postmenopausal women. Although the non-selective estrogen receptor-alpha and -beta agonist 17beta-estradiol ... [more ▼]

OBJECTIVE: Cardiac mass increases with age and with declining estradiol serum levels in postmenopausal women. Although the non-selective estrogen receptor-alpha and -beta agonist 17beta-estradiol attenuates cardiac hypertrophy in animal models and in observational studies, it remains unknown whether activation of a specific estrogen receptor subtype (ERalpha or ERbeta) might give similar or divergent results. Therefore, we analyzed myocardial hypertrophy as well as cardiac function and gene expression in ovariectomized, spontaneously hypertensive rats (SHR) treated with the subtype-selective ERalpha agonist 16alpha-LE2 or 17beta-estradiol. METHODS AND RESULTS: Long-term administration of 16alpha-LE2 or 17beta-estradiol did not affect elevated blood pressure, but both agonists efficiently attenuated cardiac hypertrophy and increased cardiac output, left ventricular stroke volume, papillary muscle strip contractility, and cardiac alpha-myosin heavy chain expression. The observed effects of E2 and 16alpha-LE2 were abrogated by the ER antagonist ZM-182780. Improved left ventricular function upon 16alpha-LE2 treatment was also observed in cardiac MRI studies. In contrast to estradiol and 16alpha-LE2, tamoxifen inhibited cardiac hypertrophy but failed to increase alpha-myosin heavy chain expression and cardiac output. CONCLUSIONS: These results support the hypothesis that activation of ERalpha favorably affects cardiac hypertrophy, myocardial contractility, and gene expression in ovariectomized SHR. Further studies are required to determine whether activation ERbeta mediates redundant or divergent effects. [less ▲]

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See detailThe Innovation Meme: Managing Innovation Replicators for Organizational Fitness
Voelpel, S; Leibold, M; Streb, Christoph Klaus UL

in Journal of Change Management (2005), 5(1), 57-69

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See detailEffects of parental differential treatment on relationship quality with siblings and parents: Justice evaluations as mediators
Boll, Thomas UL; Ferring, Dieter UL; Filipp, S.-H.

in Social Justice Research (2005), 18(2), 155-182

Based on equity theory, the present study analyzes to what extent justice evaluations mediate the effects of perceived parental differential treatment (PDT) on relationship quality with siblings and ... [more ▼]

Based on equity theory, the present study analyzes to what extent justice evaluations mediate the effects of perceived parental differential treatment (PDT) on relationship quality with siblings and parents as experienced in middle adulthood. Middle-aged adult offspring (N = 709) rated how often they and a sibling received parental recognition, nurturance, and demands for assuming filial responsibility. In addition, they indicated their justice evaluations of PDT and completed measures of relationship quality to sibling and parents. Justice evaluations emerged as either partial or complete mediators between PDT and relationship quality. Moreover, justice evaluations turned out to be more powerful predictors of relationship quality to parents than PDT per se. Implications are discussed concerning factors contributing to justice evaluations and the role of PDT within the context of other justice issues in families. [less ▲]

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See detailDe nouvelles orientations pour la politique européenne en matière de services financiers
Prüm, André UL

in Revue de Droit Bancaire et Financier (2005), (5), 3

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See detailSize-dependent Photoconductivity in MBE-Grown GaN-Nanowires
Calarco, Raffaella; Marso, Michel UL; Richter, Thomas et al

in Nano Letters (2005), 5(5), 981-984

We report on electrical transport in the dark and under ultraviolet (UV) illumination through GaN nanowhiskers grown by molecular beam epitaxy (MBE), which is sensitively dependent on the column diameter ... [more ▼]

We report on electrical transport in the dark and under ultraviolet (UV) illumination through GaN nanowhiskers grown by molecular beam epitaxy (MBE), which is sensitively dependent on the column diameter. This new effect is quantitatively described by a size dependent surface recombination mechanism. The essential ingredient for the interpretation of this effect is a diameter dependent recombination barrier, which arises from the interplay between column diameter and space charge layer extension at the column surface. [less ▲]

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See detailIncreased mortality and aggravation of heart failure in estrogen receptor-beta knockout mice after myocardial infarction.
Pelzer, Theo; Loza, Paula-Anahi Arias; Hu, Kai et al

in Circulation (2005), 111(12), 1492-8

BACKGROUND: Lower mortality rates among women with chronic heart failure than among men may depend in part on the action of female sex hormones, especially estrogens. The biological effects of estrogens ... [more ▼]

BACKGROUND: Lower mortality rates among women with chronic heart failure than among men may depend in part on the action of female sex hormones, especially estrogens. The biological effects of estrogens are mediated by 2 distinct estrogen receptor (ER) subtypes (ERalpha and ERbeta). The present study was undertaken to determine the role of ERbeta in the development of chronic heart failure after experimental myocardial infarction (MI). METHODS AND RESULTS: Female ERbeta null mice (BERKO(Chapel Hill)) and wild-type littermates (WT) were ovariectomized, given 17beta-estradiol, and subjected to chronic anterior MI (MI; BERKO n=31, WT n=30) or sham operation (sham; BERKO n=14, WT n=14). At 8 weeks after MI, both genotypes revealed left ventricular remodeling and impaired contractile function at similar average infarct size (BERKO-MI 32.9+/-5% versus WT-MI 33.0+/-4%); however, BERKO mice showed increased mortality (BERKO-MI 42% versus WT-MI 23%), increased body weight and fluid retention (P<0.01), higher ventricular pro-ANP expression (BERKO-MI 27.9-fold versus sham, WT-MI 5.2-fold versus sham; BERKO-MI versus WT-MI P<0.001), higher atrial natriuretic peptide serum levels, and increased phospholamban expression (P<0.05) compared with WT mice. CONCLUSIONS: Systemic deletion of ERbeta in female mice increases mortality, aggravates clinical and biochemical markers of heart failure, and contributes to impaired expression of Ca(2+)-handling proteins in chronic heart failure after MI. Further studies are required to delineate the relative importance of cardiac and vascular effects of ERbeta and the role of ERalpha in the development of heart failure. [less ▲]

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See detailBow to your partner for signaling.
Hermanns, Heike M.; Muller-Newen, Gerhard; Heinrich, Peter C. et al

in Nature Structural and Molecular Biology (2005), 12(6), 476-8

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See detailProperties of Equivalence Scales in Different Countries
Koulovatianos, Christos UL; Schröder, Carsten; Schmidt, Ulrich

in Journal of Economics (2005), 86

Recent studies in high-income industrialized countries have shown that equivalence scales are income-dependent. We investigate whether this dependence also holds in poorer, services oriented countries, by ... [more ▼]

Recent studies in high-income industrialized countries have shown that equivalence scales are income-dependent. We investigate whether this dependence also holds in poorer, services oriented countries, by considering the example of Cyprus. We also examine whether household economies of scale and relative children costs differ. [less ▲]

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See detailThe Need for Regulating Income Trusts: A Bubble Theory
Zetzsche, Dirk Andreas UL

in University of Toronto Faculty of Law Review (2005)

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See detailIsotropic-nematic interfacial tension of hard and soft rods: Application of advanced grand canonical biased-sampling techniques
Vink, R. L. C.; Wolfsheimer, S.; Schilling, Tanja UL

in Journal of Chemical Physics (2005), 123(7),

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See detailRadioresistance of K-Ras mutated human tumor cells is mediated through EGFR-dependent activation of PI3K-AKT pathway
Toulany, M; Dittmann, K; Krüger, Maren UL et al

in Radiotherapy and Oncology (2005), 76(2), 143-150

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See detailIntroduction
Tröhler, Daniel UL

in Annales Pestalozzi (2005), 3(1), 3-6

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See detail1alpha,25-Dihydroxyvitamin D3 is a potent suppressor of interferon gamma-mediated macrophage activation.
Helming, Laura; Bose, Jens; Ehrchen, Jan et al

in Blood (2005), 106(13), 4351-8

1alpha,25-Dihydroxyvitamin D3 (1alpha,25(OH)2D3), the activated vitamin D3 hormone, is a key regulator of calcium homeostasis and thereby indispensable for bone metabolism. In addition, 1alpha,25(OH)2D3 ... [more ▼]

1alpha,25-Dihydroxyvitamin D3 (1alpha,25(OH)2D3), the activated vitamin D3 hormone, is a key regulator of calcium homeostasis and thereby indispensable for bone metabolism. In addition, 1alpha,25(OH)2D3 is known to mediate predominantly immunosuppressive responses in vitro and in vivo. It has been demonstrated that macrophages can produce 1alpha,25(OH)2D3 on activation with interferon gamma (IFN-gamma), although little is understood about the biologic significance of this response. We show here that 1alpha,25(OH)2D3 can selectively suppress key effector functions of IFN-gamma-activated macrophages. Among these are the suppression of listericidal activity, the inhibition of phagocyte oxidase-mediated oxidative burst, and the suppression of important IFN-gamma-induced genes, including Ccl5, Cxcl10, Cxcl9, Irf2, Fcgr1, Fcgr3, and Tlr2. The deactivation of IFN-gamma-stimulated macrophages is dependent on a functional vitamin D receptor and 1alpha,25(OH)2D3 acts specifically on IFN-gamma-activated macrophages, whereas the steroid has no effects on resting macrophages. Therefore, the 1alpha,25(OH)2D3-mediated suppression of macrophage functions is distinct from previously described macrophage deactivation mechanisms. In conclusion, our data indicate that the production of 1alpha,25(OH)2D3 by IFN-gamma-stimulated macrophages might be an important negative feedback mechanism to control innate and inflammatory responses of activated macrophages. [less ▲]

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See detailA bioinformatics perspective on proteomics: Data storage, analysis, and integration
Kremer, A.; Schneider, Reinhard UL; Terstappen, G. C.

in Bioscience Reports (2005), 25(1-2), 95-106

The field of proteomics is advancing rapidly as a result of powerful new technologies and proteomics experiments yield a vast and increasing amount of information. Data regarding protein occurrence ... [more ▼]

The field of proteomics is advancing rapidly as a result of powerful new technologies and proteomics experiments yield a vast and increasing amount of information. Data regarding protein occurrence, abundance, identity, sequence, structure, properties, and interactions need to be stored. Currently, a common standard has not yet been established and open access to results is needed for further development of robust analysis algorithms. Databases for proteomics will evolve from pure storage into knowledge resources, providing a repository for information (meta-data) which is mainly not stored in simple flat files. This review will shed light on recent steps towards the generation of a common standard in proteomics data storage and integration, but is not meant to be a comprehensive overview of all available databases and tools in the proteomics community. [less ▲]

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See detailDe diversificatie van de Poolse energiesector
Venken, Machteld UL

in Oost-Europa Tijdingen (2005)

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See detailChanges in diabetes prevalence and treatment in the last ten years in Luxembourg. A lesson from the United Kingdom prospective diabetes study?
Perquin, M.; Michel, G. H.; De Beaufort, Carine UL et al

in Diabetes and Metabolism (2005), 31(5), 499-502

Objectives: The aims of the study were to estimate the prevalence of diabetes in Luxembourg in 2002, to compare it to the prevalence reported in 1991 and to evaluate if prescription attitudes have changed ... [more ▼]

Objectives: The aims of the study were to estimate the prevalence of diabetes in Luxembourg in 2002, to compare it to the prevalence reported in 1991 and to evaluate if prescription attitudes have changed since 1991. Methods: The prevalence of diabetes was estimated using the drug sales data. The key parameters, total amount of antidiabetic drugs sold in one year and the average daily dose or Prescribed Daily Dose (PDD), have been obtained from the National Social Security Organization and by a standardized questionnaire sent to all general practitioners and all internists and endocrinologists of the country. Results: The PDD was calculated on 2, 402 questionnaires on individual diabetic patients. By this means, the proportion of patients only treated with appropriate diet could also be obtained. Compared to 1991, the total amount of antidiabetic drugs showed a four-fold increase in metformine tablet prescriptions. A high percentage of combined treatments was found. The prevalence of diabetes in Luxembourg was found to be 3.05% of the total population. Conclusions: Compared to the status in 1991, prevalence of diabetes increased by 63%, which seems mainly due to type 2 diabetic patients as orally-treated diabetic patients almost doubled (2.11% vs 1.16%). A substantial change in prescriptions for diabetes has occurred, suggesting a positive influence of studies like the United Kingdom Prospective Diabetes Study (UKPDS). © 2005 Masson, all rights reserved. [less ▲]

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See detailEarly-stage folding in proteins (in silico) sequence-to-structure relation
Brylinski, Michal; Konieczny, Leszek; Czerwonko, Patryk et al

in Journal of Biomedicine & Biotechnology (2005), 2005(2), 65-79

A sequence-to-structure library has been created based on the complete PDB database. The tetrapeptide was selected as a unit representing a well-defined structural motif. Seven structural forms were ... [more ▼]

A sequence-to-structure library has been created based on the complete PDB database. The tetrapeptide was selected as a unit representing a well-defined structural motif. Seven structural forms were introduced for structure classification. The early-stage folding conformations were used as the objects for structure analysis and classification. The degree of determinability was estimated for the sequence-to-structure and structure-to-sequence relations. Probability calculus and informational entropy were applied for quantitative estimation of the mutual relation between them. The structural motifs representing different forms of loops and bends were found to favor particular sequences in structure-to-sequence analysis. [less ▲]

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See detailUltrafast metal-semiconductor-metal photodetectors on low-temperature-grown GaN
Mikulics, M.; Marso, Michel UL; Javorka, P. et al

in Applied Physics Letters (2005), 86(21), 211110

We have fabricated and characterized ultrafast metal-semiconductor-metal photodetectors based on low-temperature-grown sLTd GaN. The photodetector devices exhibit up to 200 kV/cm electric breakdown fields ... [more ▼]

We have fabricated and characterized ultrafast metal-semiconductor-metal photodetectors based on low-temperature-grown sLTd GaN. The photodetector devices exhibit up to 200 kV/cm electric breakdown fields and subpicosecond carrier lifetime. We recorded as short as 1.4-ps-wide electrical transients using 360-nm-wavelength and 100-fs-duration laser pulses, that is corresponding to the carrier lifetime of 720 fs in our LT GaN material. [less ▲]

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See detailCentral limit theorems for sequences of multiple stochastic integrals
Nualart, David; Peccati, Giovanni UL

in Annals of Probability (2005), 33(1), 177--193

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See detailHow is practice possible?
Biesta, Gert UL

in Philosophy of Education Yearbook (2005)

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See detailZerrbild "Zersiedelung": Anmerkungen zum Gebrauch und zur Dekonstruktion eines Begriffs.
Hesse, Markus UL; Kaltenbrunner, Robert

in D.I.S.P. Dokumente und Informationen zur Schweizerischen Orts-, Regional- und Landesplanung (2005), 41(1), 16-22

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See detailSchémas d'approximation associés à une équation différentielle dirigée par une fonction höldérienne; cas du mouvement brownien fractionnaire
Nourdin, Ivan UL

in Comptes Rendus de l'Académie des Sciences. Série I. Mathématique (2005), 340(8), 611-614

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See detailSex in the city. La prostitution à Bruxelles pendant la Grande Guerre (1914-1918)
Majerus, Benoît UL

in Cahiers de la Fonderie (2005), (32), 51--54

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See detailSportliche Aktivität, Fitness und Wohlbefinden Luxemburger Schülerinnen und Schüler.
Wydra, Georg; Scheuer, Claude UL; Winchenbach, Heike et al

in Sportunterricht (2005), 54

Es wird eine empirische Untersuchung vorgestellt, bei der die Frage beantwortet werden soll, ob sich die Fitness luxemburger Schülerinnen und Schüler in den letzten zwei Jahrzehnten verschlechtert hat ... [more ▼]

Es wird eine empirische Untersuchung vorgestellt, bei der die Frage beantwortet werden soll, ob sich die Fitness luxemburger Schülerinnen und Schüler in den letzten zwei Jahrzehnten verschlechtert hat. Hierzu wurden sportmotorische Tests durchgeführt und mit Normwerten aus dem Jahr 1985 verglichen. Es zeigen sich hoch signifikante schlechtere Fitnesswerte der luxemburger Jungen und Mädchen. Die Fitnesswerte von rund drei Viertel der Mädchen können als schlecht bezeichnet werden. Nur die 14-jährigen Jungen erreichen die Normwerte. Die Fitness hängt dabei nicht von der Zahl der angegebenen Sportstunden pro Woche ab. Einen hoch signifikanten Einfluss hat hingegen die Zugehörigkeit zu einem Sportverein. Es zeigen sich des Weiteren Auswirkungen auf die Gesundheit. Die fitteren Kinder haben ein hoch signifikant besseres allgemeines Wohlbefinden als die weniger leistungsfähigen. [less ▲]

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See detailMIMO Channel Capacity and Modeling Issues on a Measured Indoor Radio Channel at 5.8 GHz
Stridh, Rickard; Yu, Kai; Ottersten, Björn UL et al

in IEEE Transactions on Wireless Communications (2005), 4(3), 895903

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See detailGeschichte und Sprache der Pädagogik
Tröhler, Daniel UL

in Zeitschrift für Pädagogik (2005), 51

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See detailAktionärslegitimation und Satzungsfreiheit - Überlegungen zu § 123 AktG idF des UMAG
Zetzsche, Dirk Andreas UL; Simon, S.

in NZG. Neue Zeitschrift für Gesellschaftsrecht (2005)

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See detailRiver networks of southern Africa: Scaling laws governing their geometry and deviations from scaling
Stankiewicz, Jacek UL; De Wit, M. J.

in Geochemistry, Geophysics, Geosystems (2005), 6(9),

Africa is tectonically and hypsometrically different to all other continents and therefore provides a unique natural laboratory for the study of river network geometry. Southern Africa is one of the more ... [more ▼]

Africa is tectonically and hypsometrically different to all other continents and therefore provides a unique natural laboratory for the study of river network geometry. Southern Africa is one of the more unusual geomorphological regions of this continent, hence our interest in the geometry of the rivers draining this region. The 14 river basins analyzed here come from the larger networks of the Orange and Limpopo rivers, as well as from the southernmost section of the continent where rivers meander through an exhumed belt of folded Paleozoic mountains. Basic scaling laws, such as Horton’s laws and Hack’s law, hold for the rivers studied here, but the parameters governing these relationships vary between networks. A strong inverse correlation between Horton’s ratio of stream numbers and mean source stream slope is observed. We believe this is the first time such a relation has been reported. Horton’s ratio of basin areas is proportional to that of stream numbers but always greater than it; this contradicts existing models that equate the two parameters. An expression for the ratio of stream lengths in terms of the ratio of stream numbers is derived theoretically and verified for the available data. The parameter governing Hack’s law, h, varies not only between networks but also with scale inside each network. Existing models provide up to four scaling regimes. Given the spatial resolution of this study, the two regimes at the middle scales are visible here. These are termed the short-range and randomness regimes, with a crossover occurring at a drainage area of approximately 800 km2 . The values for h in the smaller short-range regime have an inverse correlation with the roughness of the topography. Observed values for h imply basins appear more elongated with increasing area; this would be more pronounced in rivers draining a smooth topography. In the randomness regime the values of h are lower, mostly between 0.5 and 0.6, with a weak positive correlation to topography roughness. This range of h corresponds to self-similar basins, but a more detailed analysis of individual stream fractality is necessary before such a conclusion can be made. [less ▲]

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See detailVon der wundersamen Bildungsvermehrung durch Ressourcenverknappung
Mein, Georg UL

in kultuRRevolution (2005), 49

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See detailThe Jak1 SH2 domain does not fulfill a classical SH2 function in Jak/STAT signaling but plays a structural role for receptor interaction and up-regulation of receptor surface expression
Radtke, S.; Haan, Serge UL; Jörissen, A. et al

in Journal of Biological Chemistry (2005), 280(27), 25760-8

The presence of a Src homology 2 (SH2) domain sequence similarity in the sequence of Janus kinases (Jaks) has been discussed since the first descriptions of these enzymes. We performed an in depth study ... [more ▼]

The presence of a Src homology 2 (SH2) domain sequence similarity in the sequence of Janus kinases (Jaks) has been discussed since the first descriptions of these enzymes. We performed an in depth study to determine the function of the Jak1 SH2 domain. We investigated the functionality of the Jak1 SH2 domain by stably reconstituting Jak1-defective human fibrosarcoma cells U4C with endogenous amounts of Jak1 in which the crucial arginine residue Arg466 within the SH2 domain has been replaced by lysine. This mutant still binds to the receptor subunits gp130 and OSMR. Moreover, the SH2 R466K mutation does not affect the subcellular distribution of Jak1 as assessed by cell fractionation and confocal microscopy of cells expressing endogenous levels of non-tagged or a yellow fluorescent protein (YFP)-tagged Jak1-R466K, respectively. Likewise, the signaling capacity of Jak1 was not affected by this point mutation. However, we found that the SH2 domain is structurally important for cytokine receptor binding and surface expression of the OSMR. [less ▲]

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See detailThe intermediate filament protein vimentin binds specifically to a recombinant integrin α2/β1 cytoplasmic tail complex and co-localizes with native α2/β1 in endothelial cell focal adhesions
Kreis, Stephanie UL; Schönfeld, H.-J. B; Melchior, C. A et al

in Experimental Cell Research (2005), 305(1), 110-121

Integrin receptors are crucial players in cell adhesion and migration. Identification and characterization of cellular proteins that interact with their short α and β cytoplasmic tails will help to ... [more ▼]

Integrin receptors are crucial players in cell adhesion and migration. Identification and characterization of cellular proteins that interact with their short α and β cytoplasmic tails will help to elucidate the molecular mechanisms by which integrins mediate bi-directional signaling across the plasma membrane. Integrin α2β1 is a major collagen receptor but to date, only few proteins have been shown to interact with the α2 cytoplasmic tail or with the α2β1 complex. In order to identify novel binding partners of a α2β1cytoplasmic domain complex, we have generated recombinant GST-fusion proteins, incorporating the leucine zipper heterodimerization cassettes of Jun and Fos. To ascertain proper functionality of the recombinant proteins, interaction with natural binding partners was tested. GST-α2 and GST-Jun α2 bound His-tagged calreticulin while GST-β1 and GST-Fos β1 proteins bound talin. In screening assays for novel binding partners, the immobilized GST-Jun α2/GST-Fos β1 heterodimeric complex, but not the single subunits, interacted specifically with endothelial cell-derived vimentin. Vimentin, an abundant intermediate filament protein, has previously been shown to co-localize with αvβ3-positive focal contacts. Here, we provide evidence that this interaction also occurs with α2β1-enriched focal adhesions and we further show that this association is lost after prolonged adhesion of endothelial cells to collagen. © 2005 Elsevier Inc. All rights reserved. [less ▲]

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See detailTranssexualität im Spannungsfeld juristischer und medizinischer Diskurse
De Silva, Adrian UL

in Zeitschrift für Sexualforschung (2005), 18(3), 258-271

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See detailZur gegenwärtigen Situation asylsuchender transgeschlechtlicher Menschen in der Bundesrepublik Deutschland
De Silva, Adrian UL; Quirling, Ilka

in Femina Politica (2005), 14(1), 70-82

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See detailAre solvation free energies of homogeneous helical peptides additive?
Staritzbichler, R.; Gu, Wei UL; Helms, V.

in Journal of Physical Chemistry B (2005), 109(40), 19000-19007

We investigated the additivity of the solvation free energy of amino acids in homogeneous helices of different length in water and in chloroform. Solvation free energies were computed by ... [more ▼]

We investigated the additivity of the solvation free energy of amino acids in homogeneous helices of different length in water and in chloroform. Solvation free energies were computed by multiconfiguration thermodynamic integration involving extended molecular dynamics simulations and by applying the generalized-born surface area solvation model to static helix geometries. The investigation focused on homogeneous peptides composed of uncharged amino acids, where the backbone atoms are kept fixed in an ideal helical conformation. We found nonlinearity especially for short peptides, which does not allow a simple treatment of the interaction of amino acids with their surroundings. For homogeneous peptides longer than five residues, the results from both methods are in quite good agreement and solvation energies are to a good extent additive. [less ▲]

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See detailFasten und (Über)-essen: Auswirkungen von Jojo-Diäten auf Parameter der kardialen sympatho-vagalen Balance
Coles, Justine; Vögele, Claus UL; Hilbert, Anja et al

in Zeitschrift für Klinische Psychologie und Psychotherapie (2005), (34), 95-103

Background: Findings from animal studies suggest sympathetic inhibition during dietary restriction as opposed to increased sympathetic activity during re-feeding. Objective: The present study investigated ... [more ▼]

Background: Findings from animal studies suggest sympathetic inhibition during dietary restriction as opposed to increased sympathetic activity during re-feeding. Objective: The present study investigated sympatho-vagal balance in relation to endocrinological parameters of malnutrition status in women diagnosed with bulimia nervosa. Methods: Sixteen female volunteers diagnosed with bulimia nervosa were categorised according to their serum profile (glucose, pre-albumin, insuline-like growth factor, TSH, leptin) into currently malnourished (i.e. fasting) versus non-malnourished (not fasting) and compared with fourteen non-eating disordered controls matched for age and BMI. Spectral components of heart rate variability (HRV) were calculated on resting heart rate data using autoregressive analysis. Results: As expected, fasting bulimic women displayed lower values of resting heart rate compared to non-fasting women and controls. Non-fasting bulimic women consistently showed lower results in the vagally mediated component and significantly higher results in the sympathetically mediated component of HRV. Conclusions: These results confirm the notion of cardiac sympathetic inhibition during caloric restriction and increased activity during periods of normal eating or bingeing. [less ▲]

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See detailMonte Carlo study of hard pentagons
Schilling, Tanja UL; Pronk, S.; Mulder, B. et al

in Physical Review. E ,Statistical, Nonlinear, and Soft Matter Physics (2005), 71(3),

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See detailWalter Herzog, Zeitgemäße Erziehung. Die Konstruktion pädagogischer Wirklichkeit.Weilerswist: Velbrück 2002
Priem, Karin UL

in Vierteljahresschrift für wissenschaftliche Pädagogik (2005), 81

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See detailImmigration, Rights and Culture: Three Approaches to the Urban
Carr, Constance UL

in Topia : Canadian Journal of Cultural Studies (2005), 13(Spring), 153-160

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See detailDAWL: A Delayed-ACK Scheme for MAC-Level Performance Enhancement of Wireless LANs
Kliazovich, Dzmitry UL; Granelli, Fabrizio

in Mobile Networks and Applications (2005), 10(5), 607-615

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See detailGeotechnical applications and conditions of the observational method
Van Baars, Stefan UL; Vrijling

in Heron (2005), 50(3),

Information observed during construction can be used to optimise the remaining parts of the construction or structure. In this article general conditions are indicated for the implementation of the ... [more ▼]

Information observed during construction can be used to optimise the remaining parts of the construction or structure. In this article general conditions are indicated for the implementation of the Observational Method in geotechnical engineering. The most important condition is that the uncertain field condition (the observational data) must be clear to measure. For example in case of a brittle soil behaviour, there is no clear indicator to show that the load is approaching the maximum resistance. If a project fulfils all general conditions, a financial risk analysis is necessary to find out whether the Observational Method is profitable. The success of implementation varies strongly per geotechnical discipline. In this article a simplified approach for a risk analysis is given and a number of geotechnical cases are discussed for which the Observational Method can lead to a financial profit. Most of these cases are already informally implemented in daily practice. [less ▲]

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See detailR&D activities at firm level in Belgium: when location matters
Bertinelli, Luisito UL; Nicolini, Rosella

in Review of Regional Studies (2005)

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See detailExpanded metabolic reconstruction of Helicobacter pylori (iIT341 GSM/GPR): an in silico genome-scale characterization of single- and double-deletion mutants.
Thiele, Ines UL; Vo, Thuy D.; Price, Nathan D. et al

in Journal of Bacteriology (2005), 187(16), 5818-30

Helicobacter pylori is a human gastric pathogen infecting almost half of the world population. Herein, we present an updated version of the metabolic reconstruction of H. pylori strain 26695 based on the ... [more ▼]

Helicobacter pylori is a human gastric pathogen infecting almost half of the world population. Herein, we present an updated version of the metabolic reconstruction of H. pylori strain 26695 based on the revised genome annotation and new experimental data. This reconstruction, iIT341 GSM/GPR, represents a detailed review of the current literature about H. pylori as it integrates biochemical and genomic data in a comprehensive framework. In total, it accounts for 341 metabolic genes, 476 intracellular reactions, 78 exchange reactions, and 485 metabolites. Novel features of iIT341 GSM/GPR include (i) gene-protein-reaction associations, (ii) elementally and charge-balanced reactions, (iii) more accurate descriptions of isoprenoid and lipopolysaccharide metabolism, and (iv) quantitative assessments of the supporting data for each reaction. This metabolic reconstruction was used to carry out in silico deletion studies to identify essential and conditionally essential genes in H. pylori. A total of 128 essential and 75 conditionally essential metabolic genes were identified. Predicted growth phenotypes of single knockouts were validated using published experimental data. In addition, in silico double-deletion studies identified a total of 47 synthetic lethal mutants involving 67 different metabolic genes in rich medium. [less ▲]

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See detail«La fortune iconographique et politique de la tour de Babel»
Roelens, Nathalie UL

in Contemporary French Civilization (2005)

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See detailThe subsystems approach to genome annotation and its use in the project to annotate 1000 genomes.
Overbeek, Ross; Begley, Tadhg; Butler, Ralph M. et al

in Nucleic Acids Research (2005), 33(17), 5691-702

The release of the 1000th complete microbial genome will occur in the next two to three years. In anticipation of this milestone, the Fellowship for Interpretation of Genomes (FIG) launched the Project to ... [more ▼]

The release of the 1000th complete microbial genome will occur in the next two to three years. In anticipation of this milestone, the Fellowship for Interpretation of Genomes (FIG) launched the Project to Annotate 1000 Genomes. The project is built around the principle that the key to improved accuracy in high-throughput annotation technology is to have experts annotate single subsystems over the complete collection of genomes, rather than having an annotation expert attempt to annotate all of the genes in a single genome. Using the subsystems approach, all of the genes implementing the subsystem are analyzed by an expert in that subsystem. An annotation environment was created where populated subsystems are curated and projected to new genomes. A portable notion of a populated subsystem was defined, and tools developed for exchanging and curating these objects. Tools were also developed to resolve conflicts between populated subsystems. The SEED is the first annotation environment that supports this model of annotation. Here, we describe the subsystem approach, and offer the first release of our growing library of populated subsystems. The initial release of data includes 180 177 distinct proteins with 2133 distinct functional roles. This data comes from 173 subsystems and 383 different organisms. [less ▲]

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See detailPerfusion-weighted magnetic resonance imaging in patients with vasospasm: a useful new tool in the management of patients with subarachnoid hemorrhage.
Hertel, Frank UL; Walter, Christof; Bettag, Martin et al

in Neurosurgery (2005), 56(1), 28-3535

OBJECTIVE: Cerebral vasospasm (VSP) is one of the most important risk factors for the development of a delayed neurological deficit after subarachnoid hemorrhage (SAH). Perfusion-weighted magnetic ... [more ▼]

OBJECTIVE: Cerebral vasospasm (VSP) is one of the most important risk factors for the development of a delayed neurological deficit after subarachnoid hemorrhage (SAH). Perfusion-weighted magnetic resonance imaging (pwMRI) provides the possibility of detecting tissue at risk for infarction. The objective of our study was to evaluate the feasibility and impact of pwMRI in the management of SAH patients. METHODS: From a consecutive series of 180 patients experiencing SAH and treated at our institution over a 3-year period, we identified 20 who underwent pwMRI during their acute illness. For these 20 patients, the results of pwMRI were compared with the results of diffusion-weighted MRI, transcranial Doppler sonography, and neurological examinations performed at the same time and with repeated pwMRI examinations of the same patient at different times. RESULTS: Nineteen of 20 patients showed perfusion changes predominantly in the time maps. Fifteen of 19 patients with changes in pwMRI had a neurological deficit at the same time. In 7 of 15 patients with neurological deterioration, transcranial Doppler sonography showed signs of VSP, whereas all 15 patients showed alterations in pwMRI. The areas of perfusion changes in pwMRI correlated well with the neurological deficits of the patients and were larger than the areas of changed diffusion in diffusion-weighted MRI performed at the same time. There were no clinical complications with regard to the pwMRI examinations. CONCLUSION: pwMRI is safe and helpful in the management of patients with VSP after SAH. The sensitivity of pwMRI is higher than that of transcranial Doppler sonography in the detection of decreased perfusion as a result of VSP. pwMRI can detect tissue at risk before definitive infarction occurs and therefore may lead to a change of therapy in those patients. [less ▲]

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See detailReview of Röbbecke, Martina, Dagmar Simon, Martin Lengwiler & Clemens Kraetsch: Inter-Disziplinieren: Erfolgsbedingungen von Forschungskooperationen
Powell, Justin J W UL

in Kölner Zeitschrift für Soziologie und Sozialpsychologie (2005), 57(4), 757-759

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See detailBook review of : E.-B. KÖRBER, Habsburgs europäische Herrschaft. Von Karl V. bis zum Ende des 16. Jahrhunderts, 2002
Weis, Monique UL

in Revue Belge de Philologie et d'Histoire (2005), 83

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See detailSmall-world network approach to identify key residues in protein-protein interaction.
del Sol Mesa, Antonio UL; O'Meara, Paul

in Proteins (2005), 58(3), 672-82

We show that protein complexes can be represented as small-world networks, exhibiting a relatively small number of highly central amino-acid residues occurring frequently at protein-protein interfaces. We ... [more ▼]

We show that protein complexes can be represented as small-world networks, exhibiting a relatively small number of highly central amino-acid residues occurring frequently at protein-protein interfaces. We further base our analysis on a set of different biological examples of protein-protein interactions with experimentally validated hot spots, and show that 83% of these predicted highly central residues, which are conserved in sequence alignments and nonexposed to the solvent in the protein complex, correspond to or are in direct contact with an experimentally annotated hot spot. The remaining 17% show a general tendency to be close to an annotated hot spot. On the other hand, although there is no available experimental information on their contribution to the binding free energy, detailed analysis of their properties shows that they are good candidates for being hot spots. Thus, highly central residues have a clear tendency to be located in regions that include hot spots. We also show that some of the central residues in the protein complex interfaces are central in the monomeric structures before dimerization and that possible information relating to hot spots of binding free energy could be obtained from the unbound structures. [less ▲]

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See detailThe role of alpha-synuclein gene multiplications in early-onset Parkinson's disease and dementia with Lewy bodies.
Hofer, A.; Berg, D.; Asmus, F. et al

in Journal of Neural Transmission (2005), 112(9), 1249-54

BACKGROUND: A triplication of the alpha-synuclein gene was found to cause autosomal dominant Lewy body disease in two distinct families. METHOD: We searched for alterations of alpha-synuclein gene dosage ... [more ▼]

BACKGROUND: A triplication of the alpha-synuclein gene was found to cause autosomal dominant Lewy body disease in two distinct families. METHOD: We searched for alterations of alpha-synuclein gene dosage and analysed the entire coding region for point mutations in 54 dementia with Lewy body disease (DLB) and in 103 young onset Parkinson's disease (PD) patients from Central Europe. RESULTS: We could not detect any quantitative alterations in the gene dosage of alpha-synuclein. Mutational screening of the entire coding region of alpha-synuclein revealed only one silent mutation V3V (adenine9guanine) in one case. CONCLUSIONS: Thus, this phenomenon appears not to be a major cause in the pathogenesis of sporadic DLB and young onset PD in this European population. [less ▲]

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See detailRegards croisés sur la discipline quotidienne
Poncelet, Débora UL

in La revue internationale de l’éducation familiale (2005), 9(1), 69-85

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See detailPrevalence of Spondylarthropathies in France : 2001
Saraux, A.; Guillemin, Francis; Guggenbuhl, P. et al

in Annals of the Rheumatic Diseases (2005), 64(10), 1431-1435

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See detailDipole-field-induced spin disorder in a nanocomposite soft magnet
Michels, Andreas UL; Vecchini, C.; Moze, O. et al

in Europhysics Letters (2005), 72(2), 249-255

We report on a study of a magnetic nanocomposite of the Nanoperm type (Fe89Zr7B3Cu1) by magnetic small-angle neutron scattering (SANS). The understanding of the magnetic microstructure of these materials ... [more ▼]

We report on a study of a magnetic nanocomposite of the Nanoperm type (Fe89Zr7B3Cu1) by magnetic small-angle neutron scattering (SANS). The understanding of the magnetic microstructure of these materials leaves much to be desired since we lack techniques capable of resolving the spin structure in the bulk with nanoscale resolution. Here, we present an analysis of the SANS signal by which one cannot only characterise the nanoscale structure of the spin system, but which allows to identify origin and structure of the perturbing field. In Nanoperm, an unusual angular anisotropy of the scattering suggests that the local spin misalignment decorates, as the most important perturbing field, dipole stray fields around the crystalline phase of the composite. [less ▲]

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See detailDevelopment of a European Combined Geodetic Network (ECGN)
Ihde, Johannes; Baker, Trevor; Bruyninx, Carine et al

in Journal of Geodynamics (2005), 40(4-5), 450-460

To ensure the long-time stability of the terrestrial reference system with an accuracy of 10‑9 in the global and continental scale, the interactions between different time-dependent influences of the ... [more ▼]

To ensure the long-time stability of the terrestrial reference system with an accuracy of 10‑9 in the global and continental scale, the interactions between different time-dependent influences of the system Earth to the terrestrial reference system and the related observation has to be considered in the evaluation models. It is proposed to establish a kinematic European Combined Geodetic Network (ECGN) and to integrate the spatial and height reference system into the Earth gravity field parameter estimation. This plan is in agreement with the foreseen IAG project of an Integrated Global Geodetic Observation System (IGGOS). In selected European stations ECGN will establish the combination of time series of spatial/geometric GNSS observations, precise levelling and tide gauge records with gravity field related observations (gravity, Earth tides). Observations are complemented with meteorological parameters, surrounding information of the stations, e.g. eccentricities and ground water level. A first call for participation in the project was directed to the implementation of the ECGN stations. These stations include the standard observation techniques GNSS (GPS/GLONASS—permanent), gravity (super conducting gravimeter and/or absolute gravimeter—permanent or repeated), levelling connections to nodal points of the European levelling network (UELN) (repeated) and meteorological parameters (permanent). A basic constituent of the ECGN stations is a local network for controlling the eccentricities at the 1 mm accuracy level in all three spatial components. For the contributing observation techniques, guidelines have been agreed upon to ensure equal observation principles [less ▲]

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See detailPolitik der Einfachheit : Stifters »Witiko«
Christians, Heiko; Kohns, Oliver UL

in Wirkendes Wort (2005), 55(3), 389-403

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See detailRömische Grabinschrift eines Freigelassenenpaares der Calveni
Binsfeld, Andrea UL

in Zeitschrift für Papyrologie und Epigraphik (2005), 151

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See detailL'autorité des marchés financiers (AMF)
Conac, Pierre-Henri UL

in Etude du Dictionnaire Juridique Bourse et Produits Financiers (2005)

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See detailDemonstration of the antiferroelectric aspect of the helical superstructures in SmC*, SmC$_α$* and SmC$_a$* liquid crystals
Lagerwall, Jan UL

in Physical Review. E ,Statistical, Nonlinear, and Soft Matter Physics (2005), 71(5), 051703

We show that the helical superstructure in chiral smectic-C-type liquid crystal phases can, if the pitch is short enough, give rise to the tristate switching characteristic of antiferroelectrics even if ... [more ▼]

We show that the helical superstructure in chiral smectic-C-type liquid crystal phases can, if the pitch is short enough, give rise to the tristate switching characteristic of antiferroelectrics even if the local commen- surate order is synpolar as in the ordinary Sm-C* phase. Since the field-induced helix unwinding exhibits a distinct threshold, in contrast to mere helix distortion, two unwinding / rewinding peaks per half cycle of an applied triangular wave voltage can be seen in the current response. By considering this antiferroelectric aspect * of the helical modulation we give a simple explanation of why the ultrashort-pitch Sm-C􏰄 phase exhibits antiferroelectric switching although its dielectric spectroscopy response is qualitatively identical to that of the synpolar Sm-C* phase. Using data from the compound MHPOCBC we show that the Sm-C*􏰄 dielectric re- sponse is well described by continuum theory. We also demonstrate that, if the pitch is very short as in MHPOCBC, helix unwinding / rewinding leave characteristic traces in the electrooptic response even in the commensurately antiferroelectric 􏰐antipolar􏰋 Sm-C*a phase, distinguishable from the switching beween the antipolar and synpolar states of this phase. [less ▲]

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See detailVirtual Footprint and PRODORIC: an integrative framework for regulon prediction in prokaryotes
Münch, Richard; Hiller, Karsten UL; Grote, Andreas et al

in Bioinformatics (2005)

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See detailPrevalence of Rheumatoid Arthritis in France : 2001
Guillemin, Francis; Saraux, A.; Guggenbuhl, P. et al

in Annals of the Rheumatic Diseases (2005), 64(10), 1427-1430

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See detailOn the Income Dependence of Equivalence Scales
Koulovatianos, Christos UL; Schröder, Carsten; Schmidt, Ulrich

in Journal of Public Economics (2005), 89(5-6), 967-996

Household consumption exhibits economies of scale as the number of household members increases. We collect survey data from two countries, Germany and France, in order to obtain direct subjective ... [more ▼]

Household consumption exhibits economies of scale as the number of household members increases. We collect survey data from two countries, Germany and France, in order to obtain direct subjective estimates of household consumption economies of scale, and, in particular, to examine an additional dimension: whether household consumption economies of scale change as living standards go up. Our data from both countries indicate strongly that household economies of scale increase as the living standard goes up. We discuss the robustness of our survey method and compare our results to these of alternative estimation methods in the literature. [less ▲]

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See detailExport Behavior and Firm Productivity in German Manufacturing - A Firm-Level Analysis
Hussinger, Katrin UL; Arnold, Jens Matthias

in Review of World Economics (2005)

This paper examines the causal relationship between productivity and exporting in German manufacturing. We find a causal link from high productivity to presence in foreign markets, as postulated by a ... [more ▼]

This paper examines the causal relationship between productivity and exporting in German manufacturing. We find a causal link from high productivity to presence in foreign markets, as postulated by a recent literature on international trade with heterogeneous firms. We apply a matching technique in order to analyze whether the presence in international markets enables firms to achieve further productivity improvements, without finding significant evidence for this. We conclude that high-productivity firms self-select themselves into export markets, while exporting itself does not play a significant role for the productivity of German firms. [less ▲]

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See detailInterfacial tension of the isotropic-nematic interface in suspensions of soft spherocylinders
Vink, R. L. C.; Schilling, Tanja UL

in Physical Review. E ,Statistical, Nonlinear, and Soft Matter Physics (2005), 71(5),

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See detailUltrafast Low-Temperature-Grown Epitaxial GaAs Photodetectors Transferred on Flexible Plastic Substrates
Mikulics, M.; Adam, R.; Marso, Michel UL et al

in IEEE Photonics Technology Letters (2005), 17(8), 1725-1727

We demonstrate low-temperature (LT)-grown GaAs photodetectors transferred on flexible polyethylene terephthalate (PET) plastic substrates. The LT-GaAs layer was patterned into 20 20 m2 chips, which after ... [more ▼]

We demonstrate low-temperature (LT)-grown GaAs photodetectors transferred on flexible polyethylene terephthalate (PET) plastic substrates. The LT-GaAs layer was patterned into 20 20 m2 chips, which after placing on the PET substrates were integrated with coplanar strip transmission lines. The devices exhibit low dark currents ( 2 10 8 A), subpicosecond photoresponse time, and signal amplitudes up to 0.9 V at the bias voltage of 80 V and under laser beam excitation power of 8 mW at 810-nm wavelength. At the highest bias ( 80 V) level, an increase of the response time (up to 1.3 ps) was observed and attributed to the influence of heating effects due to low thermal conductivity of PET. Our LT-GaAs-on-PET photodetectors withstand hundredfold mechanical bending of the substrate and are intended for applications in hybrid optoelectronic circuits fabricated on noncrystalline substrates, in terahertz imaging, and in biology-related current-excitation tests. [less ▲]

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See detailComment on "thermal glass transition beyond the vogel-fulcher-tammann behavior for glass forming diglycidylether of bisphenol A".
Rivera, A.; Blochowicz, T.; Porokhonskyy, V. et al

in Physical Review Letters (2005), 94(12), 129603-129604

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See detailBook review of : F. EDELMAYER, Söldner und Pensionäre. Das Netzwerk Philipps II. im Heiligen Römischen Reich, 2002
Weis, Monique UL

in Revue Belge de Philologie et d'Histoire (2005), 83

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See detailManifestes und wissenschaftliches Weltbild. Kritische Bemerkungen zu Sellars’ Theorie des Wandels von Begriffssystemen
Heidemann, Dietmar UL

in Internationale Zeitschrift für Philosophie (2005), 2

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See detailOn track for a 2-hour marathon
Stankiewicz, Jacek UL

in South African Journal of Science (2005), 101(9-10), 397-398

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See detailLes bons de souscription d'actions "Plavix" et les principes généraux des offres publiques
Conac, Pierre-Henri UL

in Revue des Sociétés (2005), (2), 321-321

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See detailStadt-Land-Unterschiede der Internetnutzung - eine empirische Untersuchung der regionalen digitalen Spaltung.
Lenz, Thomas UL; Jäckel, Michael; Zillien, Nicole

in merz | medien + erziehung, die Zeitschrift für Medienpädagogik (2005), 6

Detailed reference viewed: 244 (1 UL)
See detailCom. 24 mai 2005
Cuniberti, Gilles UL

in DR. & PROC. (2005)

Domaine de l’exclusion „faillite“ de la Convention de Bruxelles.

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See detailFormer des professeures autonomes et responsables, est-ce possible?
Weber, Jean-Marie UL

in Transfert (2005), 2

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See detailQuali sono gli obiettivi educativi privilegiati dalle famiglie ?
Poncelet, Débora UL

in Psicologia Dell’ Educazione E Della Formazione (2005), 7(2), 155-169

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See detailPromoter-hypermethylation is causing functional relevant downregulation of methylthioadenosine phosphorylase (MTAP) expression in hepatocellular carcinoma
Hellerbrand, C.; Mühlbauer, M.; Wallner, S. et al

in Carcinogenesis (2005), 27(1), 64-72

The methylthioadenosine phosphorylase (MTAP) gene is localized in the chromosomal region 9p21. Here, frequently homozygous deletions occur in several kinds of cancer associated with the loss of tumour ... [more ▼]

The methylthioadenosine phosphorylase (MTAP) gene is localized in the chromosomal region 9p21. Here, frequently homozygous deletions occur in several kinds of cancer associated with the loss of tumour suppressor genes as p16 and p15. The aim of this study was to analyse MTAP expression in hepatocellular carcinoma (HCC) and to get an insight into the regulation and functional role of MTAP in hepatocancerogenesis. Compared with primary human hepatocytes MTAP expression was markedly downregulated in three different HCC cell lines as determined by real-time PCR and western blotting. This was not due to genomic losses or mutations but to promoter-hypermethylation. Reduced MTAP-expression was confirmed in vivo in HCC compared with non-cancerous liver tissue on both mRNA and protein levels. To study the functional relevance of the downregulated MTAP expression in HCC, MTAP expression was re-induced in HCC cell lines by stable transfection. In these MTAP re-expressing cell clones the invasive potential was strongly reduced, whereas no effects on cell proliferation were observed in comparison with mock transfected cell clones. Furthermore, in MTAP re-expressing cells interferon (IFN)-alpha and IFN-gamma induced a significantly stronger inhibition of cell proliferation than in mock transfected cells. In conclusion, our results suggest a functional role of MTAP inactivation in HCC development and invasiveness. Furthermore, in the light of a recent report revealing an association between MTAP activity and IFN sensitivity, our findings may have clinical significance for therapeutic strategies. [less ▲]

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See detailLoss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease.
Strauss, Karsten M.; Martins, Luisa UL; Plun-Favreau, Helene et al

in Human molecular genetics (2005), 14(15), 2099-111

Recently targeted disruption of Omi/HtrA2 has been found to cause neurodegeneration and a parkinsonian phenotype in mice. Using a candidate gene approach, we performed a mutation screening of the Omi ... [more ▼]

Recently targeted disruption of Omi/HtrA2 has been found to cause neurodegeneration and a parkinsonian phenotype in mice. Using a candidate gene approach, we performed a mutation screening of the Omi/HtrA2 gene in German Parkinson's disease (PD) patients. In four patients, we identified a novel heterozygous G399S mutation, which was absent in healthy controls. Moreover, we identified a novel A141S polymorphism that was associated with PD (P<0.05). Both mutations resulted in defective activation of the protease activity of Omi/HtrA2. Immunohistochemistry and functional analysis in stably transfected cells revealed that S399 mutant Omi/HtrA2 and to a lesser extent, the risk allele of the A141S polymorphism induced mitochondrial dysfunction associated with altered mitochondrial morphology. Cells overexpressing S399 mutant Omi/HtrA2 were more susceptible to stress-induced cell death than wild-type. On the basis of functional genomics, our results provide a novel link between mitochondrial dysfunction and neurodegeneration in PD. [less ▲]

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See detailKonstellationen und Mechanismen geschlechtlicher Lohndiskriminierung in Österreich
Hoenig, Barbara UL; Kreimer, Margareta

in Österreichische Zeitschrift für Soziologie (2005), 30(1), 44-66

Der Ausgangspunkt dieses Beitrags ist der anhaltend hohe Einkommensunterschied zwischen den Geschlechtern in Österreich. Auf der Basis einer empirischen Fallstudie in drei Berufsgruppen (ungelernte ... [more ▼]

Der Ausgangspunkt dieses Beitrags ist der anhaltend hohe Einkommensunterschied zwischen den Geschlechtern in Österreich. Auf der Basis einer empirischen Fallstudie in drei Berufsgruppen (ungelernte ArbeiterInnen in der Nahrungsmittelindustrie, AHS-LehrerInnen, akademische TechnikerInnen) setzen wir uns mit dem Zusammenspiel von Lohnsystemen und arbeitsplatzbezogenen Praktiken auseinander, um einen Beitrag zur Erklärung der Ursachen und der Stabilität der Lohndiskriminierung zu leisten. Vor dem theoretischen Hintergrund der Relationalität, der sozialen Konstruktion von Geschlecht und des Konzepts der gendered substructure haben wir zentrale Konstellationen und Mechanismen der Einkommensdiskriminierung in ihren normativen und mikrosozialen Dimensionen und kollektiven Regelungsstrukturen untersucht. Die Ergebnisse liefern Anknüpfungspunkte für Strategien zum Abbau geschlechtlicher Lohndiskriminierung. [less ▲]

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See detailSpannungsfeld Berufsdomäne - Wirkt sich die Tätigkeit in einer Männer- oder Frauendomäne negativ auf das Karriereverhalten von Frauen und Männern aus?
Sturny, Angelika; Krolak-Schwerdt, Sabine UL; Wintermantel, Margret

in Zeitschrift für Sozialmanagement (2005), 3

Anhand von drei empirischen Studien wurde überprüft, welchen Einfluss die Tätigkeit in einer geschlechtsspezifischen Berufsdomäne (z. B. in einer Männer oder Frauendomäne) auf die Wahrnehmung und das ... [more ▼]

Anhand von drei empirischen Studien wurde überprüft, welchen Einfluss die Tätigkeit in einer geschlechtsspezifischen Berufsdomäne (z. B. in einer Männer oder Frauendomäne) auf die Wahrnehmung und das Erleben erwerbstätiger Männer und Frauen ausübt. Mittelpunkt der Untersuchung waren Erwerbstätige, die in einer Berufsdomäne tätig sind, die nicht mit ihrer Geschlechtsrolle übereinstimmt. [less ▲]

Detailed reference viewed: 77 (2 UL)
Peer Reviewed
See detailBeyond annotation transfer by homology: novel protein-function prediction methods to assist drug discovery
Ofran, Y.; Punta, M.; Schneider, Reinhard UL et al

in Drug Discovery Today (2005), 10(21), 1475-1482

Every entirely sequenced genome reveals 100s to 1000s of protein sequences for which the only annotation available is 'hypothetical protein'. Thus, in the human genome and in the genomes of pathogenic ... [more ▼]

Every entirely sequenced genome reveals 100s to 1000s of protein sequences for which the only annotation available is 'hypothetical protein'. Thus, in the human genome and in the genomes of pathogenic agents there could be 1000s of potential, unexplored drug targets. Computational prediction of protein function can play a role in studying these targets. We shall review the challenges, research approaches and recently developed tools in the field of computational function-prediction and we will discuss the ways these issues can change the process of drug discovery. [less ▲]

Detailed reference viewed: 134 (0 UL)