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See detailCytostatic hydroxycoumarin OT52 induces ER/Golgi stress and STAT3 inhibition triggering non-canonical cell death and synergy with BH3 mimetics in lung cancer.
Lee, JY; Talhi, O; Jang, D et al

in Cancer Letters (2018)

Coumarins are natural compounds with antioxidant, anti-inflammatory and anti-cancer potential known to modulate inflammatory pathways. Here, non-toxic biscoumarin OT52 strongly inhibited proliferation of ... [more ▼]

Coumarins are natural compounds with antioxidant, anti-inflammatory and anti-cancer potential known to modulate inflammatory pathways. Here, non-toxic biscoumarin OT52 strongly inhibited proliferation of non-small cell lung cancer cells with KRAS mutations, inhibited stem-like characteristics by reducing aldehyde dehydrogenase expression and abrogated spheroid formation capacity. This cytostatic effect was characterized by cell cycle arrest and onset of senescence concomitant with endoplasmic reticulum and Golgi stress, leading to metabolic alterations. Mechanistically, this cellular response was associated with the novel capacity of biscoumarin OT52 to inhibit STAT3 transactivation and expression of its target genes linked to proliferation. These results were validated by computational docking of OT52 to the STAT3 DNA-binding domain. Combination treatments of OT52 with subtoxic concentrations of Bcl-xL and Mcl-1-targeting BH3 protein inhibitors triggered synergistic immunogenic cell death validated in colony formation assays as well as in vivo by zebrafish xenografts. [less ▲]

Detailed reference viewed: 45 (0 UL)
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See detailCytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor
Kischkel, F. C.; Hellbardt, S.; Behrmann, Iris UL et al

in EMBO Journal (1996), 14(22), 5579-88

APO-1 (Fas/CD95), a member of the tumor necrosis factor receptor superfamily, induces apoptosis upon receptor oligomerization. In a search to identify intracellular signaling molecules coupling to ... [more ▼]

APO-1 (Fas/CD95), a member of the tumor necrosis factor receptor superfamily, induces apoptosis upon receptor oligomerization. In a search to identify intracellular signaling molecules coupling to oligomerized APO-1, several cytotoxicity-dependent APO-1-associated proteins (CAP) were immunoprecipitated from the apoptosis-sensitive human leukemic T cell line HUT78 and the lymphoblastoid B cell line SKW6.4. CAP1-3 (27-29 kDa) and CAP4 (55 kDa), instantly detectable after the crosslinking of APO-1, were associated only with aggregated (the signaling form of APO-1) and not with monomeric APO-1. CAP1 and CAP2 were identified as serine phosphorylated MORT1/FADD. The association of CAP1-4 with APO-1 was not observed with C-terminally truncated non-signaling APO-1. In addition, CAP1 and CAP2 did not associate with an APO-1 cytoplasmic tail carrying the lprcg amino acid replacement. Moreover, no APO-1-CAP association was found in the APO-1+, anti-APO-1-resistant pre-B cell line Boe. Our data suggest that in vivo CAP1-4 are the APO-1 apoptosis-transducing molecules. [less ▲]

Detailed reference viewed: 66 (0 UL)
See detailD is for democracy: Critical education between inclusion and interruption
Biesta, Gert UL

in Ze’ev, I. Gur (Ed.) The possibility/impossibiloity of a new critical language in education. (2010)

Detailed reference viewed: 56 (0 UL)
See detailD wie Damals
Heimböckel, Dieter UL

Article for general public (2012)

Detailed reference viewed: 45 (0 UL)
See detailD'"Erfanne" vun der Nationalliteratur am Essai sur la poésie luxembourgeoise (1854) vum Félix Thyes
Glesener, Jeanne UL

in Millim, Anne-Marie; De Toffoli, Ian (Eds.) Madernismen in Luxemburg. Traditionen-Variationen-Brüche. Modernismes au Luxembourg. Traditions-Variations-Ruptures (2019)

Detailed reference viewed: 69 (0 UL)
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See detailD’Aarbechtsgediechtnes an d’Léiere bei Kanner
Engel de Abreu, Pascale UL

Article for general public (2011)

Dës Brochure soll derzou bäidroen, fir Iech d’Konzept “Aarbechtsgediechtnes” méi nozebréngen. Dir fannt an dëser Brochure Informatiounen iwwer d’Verbindung tëschent dem Aarbechtsgediechtnes an dem Léiere ... [more ▼]

Dës Brochure soll derzou bäidroen, fir Iech d’Konzept “Aarbechtsgediechtnes” méi nozebréngen. Dir fannt an dëser Brochure Informatiounen iwwer d’Verbindung tëschent dem Aarbechtsgediechtnes an dem Léiere bei Kanner; iwwer méiglech Léierschwieregkeete vu Kanner mat Aarbechtsgediechtnesproblemer; a wéi een dës Problemer an der Klass erkenne kann an deem entgéintwierke kann. Ech beschreiwen och kuerz mäin aktuelle Fuerschungsprojet op der Universitéit Lëtzebuerg, dee sech mat den Auswierkunge vun der Méisproochegkeet op d’Aarbechtsgediechtnes beschäftegt. [less ▲]

Detailed reference viewed: 98 (6 UL)
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See detail“D’après une histoire vraie”
Barthelmebs-Raguin, Hélène UL

in Ferry, Ariane; Provini, Sandra (Eds.) Figures et personnages de criminelles, des histoires tragiques au roman policier (in press)

Detailed reference viewed: 27 (0 UL)
See detailD'Atlantropa à Desertec: macro-projeter le continent ressource du 20e siècle
Hertweck, Florian UL; Lopez, Fanny

in Rouillard, Dominique (Ed.) Afriques. Architecture, infrastructures et territoires en devenir (2015)

Detailed reference viewed: 92 (1 UL)
See detailD'Chancegläichheet vun Fraën a Männer an der Städtepolitik
Becker, Tom UL

Scientific Conference (2009)

Detailed reference viewed: 33 (0 UL)
See detailD’Chorale Municipale vu Schëffleng. E ganz besonnesche Chouer
Sagrillo, Damien UL

in Sagrillo, Damien; Gliedner, Gilbert (Eds.) Joer Chorale Municipale. 50 Joer Chorale “Minettsro’sen Schëffleng 2014 (2016)

Detailed reference viewed: 34 (0 UL)
See detailD’Exekutivfunktiounen an d’Sproochentwécklung bei jonken Immigrantekanner zu Lëtzebuerg
Engel de Abreu, Pascale UL

Conference given outside the academic context (2012)

Detailed reference viewed: 71 (2 UL)
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See detailD'Fangeren ewech vum Index...
Scuto, Denis UL

Article for general public (2016)

Detailed reference viewed: 41 (4 UL)
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See detailD'Gëlle Fra
Majerus, Benoît UL

in Kmec, Sonja; Majerus, Benoît; Margue, Michel (Eds.) et al Lieux de mémoire au Luxembourg. Usages du passé et construction nationale (2007)

Detailed reference viewed: 259 (17 UL)
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See detailD'Italiener
Cicotti, Claudio UL

in Kmec, S.; Margue, M.; Majerus, B. (Eds.) et al Lieux de mémoire. Usage du passé et construction nationale (2007)

Detailed reference viewed: 39 (3 UL)
See detailD’Lëtzebuerger Republik : von Schande und Scheitern
Wagener, Renée UL

in Kmec, Sonja; Peporte, Pit (Eds.) Lieux de mémoire au Luxembourg - Erinnerungsorte in Luxemburg. Vol. 2 (2012)

Detailed reference viewed: 52 (3 UL)
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See detailD’méisproochegt Gehir
Engel de Abreu, Pascale UL

E-print/Working paper (2014)

Den „kognitive Virdeel“ vun der Méisproochegkeet besteet doranner, datt méisproocheg Kanner a bestëmmte kognitiven Aufgaben, déi déi sougenannten „Exekutivfunktioune“ moossen, besser si wéi Kanner, déi ... [more ▼]

Den „kognitive Virdeel“ vun der Méisproochegkeet besteet doranner, datt méisproocheg Kanner a bestëmmte kognitiven Aufgaben, déi déi sougenannten „Exekutivfunktioune“ moossen, besser si wéi Kanner, déi nëmmen eng Sprooch schwätzen. [less ▲]

Detailed reference viewed: 135 (8 UL)
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See detailD’méisproochegt Gehir
Engel de Abreu, Pascale UL

Conference given outside the academic context (2014)

The multilingual brain. Is a multilingual education beneficial for children? What are the optimal conditions under which a child can become perfectly multilingual? The given lecture will focus on the ... [more ▼]

The multilingual brain. Is a multilingual education beneficial for children? What are the optimal conditions under which a child can become perfectly multilingual? The given lecture will focus on the "cognitive advantages" of multilingualism and illustrate the impact that being multilingual has on the cognitive organisation of the brain. Practical questions regarding multilingual education will also be discussed. [less ▲]

Detailed reference viewed: 65 (4 UL)
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See detailD’méisproochegt Gehir
Engel de Abreu, Pascale UL

Conference given outside the academic context (2014)

Est-ce vraiment bien, pour nos enfants, d’apprendre à parler plusieurs langues en même temps ? Comment les aider au mieux à progresser ? Notre première invitée, Madame Pascale Engel de Abreu, Professeur à ... [more ▼]

Est-ce vraiment bien, pour nos enfants, d’apprendre à parler plusieurs langues en même temps ? Comment les aider au mieux à progresser ? Notre première invitée, Madame Pascale Engel de Abreu, Professeur à UNI.LU (Université du Luxembourg) et psychologue du développement cognitif, illustrera les influences du multilinguisme sur l’organisation du cerveau ; elle décrira les conditions optimales pour qu’un enfant puisse devenir parfaitement multilingue ; puis abordera des questions plus pratiques liées au cadre familial et à la vie quotidienne de nos enfants. Toujours sur le thème du multilinguisme, Madame Angélique Quintus et Madame Flore Schank, (fonction) nous parleront ensuite de certains projets mis en place ou en phase d’étude, par le Ministère de l’Education Nationale. [less ▲]

Detailed reference viewed: 275 (4 UL)
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See detailD’Natioun fir d’Dynastie. La fête ‘nationale’ au Luxembourg aux 19e et 20e siècles
Majerus, Benoît UL

in Kalbasslamettanationalpilgeralbum. Traditions en migration (2006)

Detailed reference viewed: 42 (3 UL)
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See detailD'Nei Bréck - ein Erinnerungsort ?
Kmec, Sonja UL

Article for general public (2007)

Detailed reference viewed: 47 (2 UL)